• vaccination
  • Not satisfied with trying to destroy the doctor, who refuses to recant and defends pursuit of scientific truth, forced vaccination proponents are now acting to kill not only freedom of thought and scientific inquiry but also freedom of speech and informed consent to voluntary use of vaccines. (blogspot.com)
  • He dared to hypothesize that a subset of children may be vulnerable, for immunological reasons, to developing vaccine strain measles virus infection triggered by MMR vaccination that causes acute and chronic inflammation in the body and can lead to persistent health problems, including a form of inflammatory bowel disease and brain dysfunction manifested by autism. (blogspot.com)
  • A late-breaking report at the annual meeting of the American Academy of Allergy, Asthma and Immunology discusses the development of live vaccine strain rotavirus infection following rotavirus vaccination in children with immune deficiencies. (blogspot.com)
  • The human-bovine genetic hybrid vaccine, Rotateq, for which Paul Offit, M.D.is a co-patent holder, caused diarrhea, acidosis, failure to thrive, dehydration and shock in two babies with undiagnosed immune system dysfunction within two months of vaccination. (blogspot.com)
  • On March 7, a British newspaper reported that no longer would duly elected legislators have ultimate responsibility for saying "yes" or "no" to new vaccine mandates but that the power to force vaccine use in Britain would be wielded by unelected physicians and scientists , who are members of the government's Joint Committee on Vaccination and Immunisation (JCVI). (blogspot.com)
  • Based on their statistical analysis, they conclude that switching to the nonavalent HPV vaccine would have the same public health and economic benefit as raising the rates of vaccination by eleven percent but would cost almost three billion dollars less. (self.com)
  • The researchers write that a cohesive national vaccination plan using the nine-strain HPV vaccine would provide the maximum economic and health benefits while limiting costs. (self.com)
  • The assessment of clinical benefit from influenza vaccination in the elderly population is complicated by varying cohorts, virulence of the influenza strain, and matching of vaccine and circulating viral strains. (dovepress.com)
  • The safety profile of Fluzone High-Dose vaccine is similar to that of regular flu vaccines, although adverse events (which are also reported after regular flu vaccines) were reported more frequently after vaccination with Fluzone High-Dose. (care2.com)
  • The 'flu' vaccination, more correctly termed the influenza vaccination, is a vaccine against specific strains of the influenza virus. (allthingshealing.com)
  • According the manufacturer of the vaccines, the flu vaccination should NOT be given to persons with an acute respiratory infection or with any other active infection or serious febrile (fever) illness. (allthingshealing.com)
  • An outbreak of almost 30,000 cases in 1990 led to a renewed push for vaccination and the addition of a second vaccine to the recommended schedule. (wikipedia.org)
  • Based on the results of animal studies, a universal flu vaccine may use a two-step vaccination strategy - priming with a DNA-based HA vaccine followed by a second dose with an inactivated, attenuated, or adenovirus-vector-based vaccine. (wikipedia.org)
  • The UK National Health Service introduced an MMR vaccine using the Urabe mumps strain in 1988, replacing it entirely with the Jeryl Lynn strain in September 1992 following the identification of an unacceptable risk of aseptic meningitis 15-35 days after vaccination. (wikipedia.org)
  • In November 1994, the latter option was chosen and a national measles and rubella vaccination campaign, described as "one of the most ambitious vaccination initiatives that Britain has undertaken" was commenced: within one month, 92% of the 7.1 million schoolchildren in England aged 5-16 years received measles and rubella (MR) vaccine. (wikipedia.org)
  • Chinese scientists announced the development of a vaccine on October 26, 2013, but said that H7N9 had not spread far enough to merit widespread vaccination. (wikipedia.org)
  • genome
  • The company owns exclusive licences for disruptive technologies that enable the computational rational design of viral genomes from the lab of Dr. Tamir Tuller of Tel-Aviv University and technology for the physical DNA editing of viral vaccine genome libraries from the lab of Prof. Ehud Shapiro from the Weizmann Institute of Science. (yedarnd.com)
  • Fusion of these membranes allows the viral proteins and genome to be released into the host cell, which then causes the infection. (wikipedia.org)
  • These results suggested that more safer vaccine strains of the Sabin type 2 and type 3 viruses can be con structed by replacing the sequence of viral capsid proteins of the Sabin 1 poliovirus by the corresponding genome sequences of the Sabin type 2 and type 3. (springer.com)
  • Core is completely uncoated as early expression ends, viral genome is now free in the cytoplasm. (wikipedia.org)
  • The Influenza Genome Sequencing Project was initiated in 2004 to create a library of influenza sequences to understand what makes one strain more lethal than another, what genetic determinants most affect immunogenicity, and how the virus evolves over time. (wikipedia.org)
  • Coronaviruses contain the largest known viral RNA genome in number of nucleotides, of approximately 30,000 bases. (wikipedia.org)
  • Sanofi Pasteur
  • A day later, another British newspaper reported that many members of the JCVI have financial ties to vaccine manufacturers, including Merck, GlaxoSmithKline, Sanofi Pasteur and Novartis and that the JVCI has been involved in past attempts to hide evidence that MMR vaccine can cause brain inflammation and permanent brain damage. (blogspot.com)
  • Fluzone High-Dose " is a new influenza vaccine manufactured by Sanofi Pasteur. (care2.com)
  • The vaccine is sold by Merck as M-M-R II, GlaxoSmithKline Biologicals as Priorix, Serum Institute of India as Tresivac, and Sanofi Pasteur as Trimovax. (wikipedia.org)
  • The companies receiving the contracts were: GlaxoSmithKline $274.8 million MedImmune Inc $169.5 million Novartis Vaccines and Diagnostics $220.5 million DynPort Vaccine Company, LLC $41 million Solvay Pharmaceuticals $298.6 million The US government purchased from Sanofi Pasteur and Chiron Corporation several million doses of vaccine meant to be used in case of an influenza pandemic due to H5N1 and is conducting clinical trials on them[when? (wikipedia.org)
  • immunization
  • On February 26, 2009, bully boy Dr. David Salisbury, the Director of Immunization at the UK Department of Health, threatened The One Click Group , a UK internet based news service founded by Jane Bryant, that he would sue them for publishing facts about MMR vaccine risks unless One Click removes the information he wants censored and apologizes for publishing it without his permission. (blogspot.com)
  • current vaccine
  • SynVaccine utilizes a multi-disciplinary approach combining cutting edge technologies including synthetic biology, virology, bio-informatics, engineering and robotics to generate a vaccine development platform positioned to overcome the limitations of current vaccine development technology. (yedarnd.com)
  • To achieve current vaccine production targets millions of 11-day old fertilized eggs must be available every day of production. (wikipedia.org)
  • Solutions to limitations in current vaccine methods are being researched. (wikipedia.org)
  • polio live
  • Kohara M, Abe S, Kuge S, Semler BL, Komatsu T, Arita M, Itoh H, Nomoto A (1986) An infectious cDNA clone of the poliovirus Sabin strain could be used as a stable repository and inoculum for the oral polio live vaccine. (springer.com)
  • avian
  • In addition, because a pandemic could result from an avian influenza strain that is lethal to chickens, it is impossible to ensure that eggs will be available to produce vaccine when needed. (wikipedia.org)
  • Before 2004, all previous highly pathogenic avian flu (HPAI) virus strains circulated only among domesticated poultry and by culling all of them in the area, the strains were made extinct. (wikipedia.org)
  • H7N9 is a bird flu strain of the species Influenza virus A (avian influenza virus or bird flu virus). (wikipedia.org)
  • Other diseases such as mycoplasmosis by Mycoplasma gallisepticum (chronic respiratory disease), Newcastle disease by mesogenic strains of Newcastle diseases virus (APMV-1), avian metapneumovirus, infectious laryngotracheitis, avian infectious coryza in some stages may clinically resemble IB. (wikipedia.org)
  • doses
  • Two infants receiving the first two of three scheduled doses of the live, attenuated-virus rotavirus vaccine (RotaTeq) developed infections traced to the product, according to Niraj C. Patel, M.D., of Baylor College of Medicine in Houston. (medpagetoday.com)
  • with vaccine production hoped to increase until one billion doses are produced by one year after the virus is first identified. (wikipedia.org)
  • genetically
  • Explain to interested patients that a three-dose schedule of rotavirus vaccine, which contains live but genetically weakened virus strains, is recommended for all infants beginning at two months of age. (medpagetoday.com)
  • Egg yield curve in BI in a parent flock Thin-shelled egg Abnormal granulations on shell Soft-shelled eggs Misshapen and discolored eggs IBV was the first coronavirus described and varies greatly genetically and phenotypically, with hundreads of serotypes and strains described. (wikipedia.org)
  • preservative
  • Despite publicity to the contrary, the controversial mercury-based vaccine preservative Thimerosal - thought by some researchers to be linked to rising levels of autism in the U.S. - is still used in some vaccines. (wnd.com)
  • Thimerosal, a mercury-containing compound, is commonly used as a preservative in flu vaccines. (allthingshealing.com)
  • mutate
  • A wild bird's LPAI would mutate in a domestic flock into an HPAI strain, all domestic birds in the area would be killed, and the HPAI strain would no longer have any hosts and thus would no longer exist. (wikipedia.org)
  • Nonetheless, there is still hope it will mutate into some low pathogenic strain over time and no longer exist in its current high pathogenic set of strains. (wikipedia.org)
  • efficacy
  • Synvaccine's technology enables the design and fabrication of viral genomes from scratch, ensuring through our safety engineering focused design process that the resultig attenuated viral vaccines strains overcome the safety and efficacy limitations of current vaccines. (yedarnd.com)
  • The development of more immunogenic vaccines through new formulations or addition of adjuvants holds the promise of revolutionizing delivery and improving efficacy. (dovepress.com)
  • MMR with the Urabe strain is much cheaper to manufacture than with the Jeryl Lynn strain, and a strain with higher efficacy along with a somewhat higher rate of mild side effects may still have the advantage of reduced incidence of overall illness. (wikipedia.org)
  • Merck
  • The manufacturer, pharmaceutical giant Merck, has lobbied state politicians to make their vaccine mandatory. (wnd.com)
  • Surprise, two weeks ago WND reported at least three deaths and more than 1,600 adverse reactions including spontaneous abortion and paralysis have already been connected to the Merck vaccine, called Gardasil. (wnd.com)
  • With no such risk seen in vaccines using the Jeryl Lynn mumps strain, the UK NHS withdrew two of the three MMR vaccines then available (Immravax, made by Merieux UK, and Pluserix, made by SmithKline Beecham) in favor of Merck Sharp and Dohme's MMR II brand, based on the Jeryl Lynn strain. (wikipedia.org)
  • seasonal
  • The purpose of this study is to evaluate the immunogenicity and the safety of GlaxoSmithKline Biologicals' seasonal influenza vaccine, Fluarix, compared to Fluzone (a US-licensed vaccine) in children, 6 to 35 months of age. (clinicaltrials.gov)
  • The new strain of influenza A is different from the virus that causes seasonal influenza in humans. (infochangeindia.org)
  • The Centers for Disease Control and Prevention are quick to reassure seniors that Fluzone is just as safe as regular seasonal flu vaccines . (care2.com)
  • While the annual flu vaccine is touted as the "best" way to avoid catching the seasonal flu, what many fail to realize is that there's virtually NO good scientific evidence to support it. (care2.com)
  • The research from Health Canada suggests that the flu vaccine that closely matches the current seasonal influenza strains temporarily prevents the flu in healthy persons less than 65 years old about 70% of the time. (allthingshealing.com)
  • Currently, influenza vaccine for the annual, seasonal influenza program comes from four manufacturers. (wikipedia.org)
  • In the near term, further expansion of these systems will provide additional capacity for the U.S.-based production of both seasonal and pandemic vaccines, however, the surge capacity that will be needed for a pandemic response cannot be met by egg-based vaccine production alone, as it is impractical to develop a system that depends on hundreds of millions of 11-day old specialized eggs on a standby basis. (wikipedia.org)
  • infections
  • Human viral infections run the gamut from annoying or embarrassing (warts and fever blisters) to chronic (herpes and hepatitis ) to potentially lethal (Ebola, HIV, and cancer-causing papillomavirus) to tragic (Zika, a mosquito-borne virus associated with serious birth defects). (whitakerwellness.com)
  • Explain that infections caused by other live-virus vaccines have been found in immunodeficient children. (medpagetoday.com)
  • Dr. Patel said molecular analyses showed that the vaccine caused the infections. (medpagetoday.com)
  • Acute sinusitis can be caused by viral, bacterial, or fungal infections. (limamemorial.org)
  • HPV vaccines, developed in the early 21st century, reduce the risk of cervical cancer by preventing infections from the main cancer-causing strains of HPV. (wikipedia.org)
  • universal flu vaccines
  • The BIO2016 convention featured a panel discussion titled "Solving the Flu Problem: Can New Technologies Lead to Universal Flu Vaccines? (wikipedia.org)
  • By 2010 some universal flu vaccines had started clinical trials. (wikipedia.org)
  • citation needed] See Prospects for universal flu vaccines The US government on May 4, 2006 awarded five-year contracts for "more than $1 billion to five drug manufacturers developing technology for speedier mass production of vaccines in the event of a pandemic" from the $3.8 billion pandemic preparedness bill passed in 2005. (wikipedia.org)
  • smallpox
  • Since smallpox vaccine, evidence that vaccines can cause acute and chronic immune-mediated inflammation in the brain and other parts of the body has been well documented in the medical literature (A literature review of evidence is featured in the 2008 book " Vaccines, Autism & Chronic Inflammation: The New Epidemic . (blogspot.com)
  • A viral GAAP (vGAAP) can also be found in some strains of vaccinia virus, the live vaccine used to eradicate smallpox. (wikipedia.org)
  • safe vaccines
  • Therefore, it is important to identify new ways of making safe vaccines able to generate strong CD8 me mory cells against soluble proteins. (europa.eu)
  • virus
  • The pertussis vaccine, for example, is notorious for having rare but horrendous side effects, and most polio cases in the world in recent years have been caused by the live-virus vaccine itself! (wnd.com)
  • Lack of universal vaccines against the highly variable influenza virus forces scientists to continuously design vaccines à la carte , which is an expensive and risky practice overall when dealing with virulent strains. (pubmedcentralcanada.ca)
  • The viral capsid proteins that contribute to viral antigenicity and immunogenicity, had a little correlation with the neurovirulence or attenuation phenotype of the virus. (springer.com)
  • Kohara M, Abe S, Komatsu T, Tago K, Arita M, Nomoto A (1988) A recombinant virus between the Sabin 1 and 3 vaccine strains of poliovirus as a possible candidate for a new type 3 poliovirus live vaccine strain. (springer.com)
  • The influenza virus, which is transmitted through droplets in the air, mutates constantly, one reason that it is monitored by a global surveillance network that tracks the virus's mutations, predicts the dominant strain circulating for the coming season and recommends the composition of the season's influenza vaccine. (infochangeindia.org)
  • The virus is always at least one step ahead of the vaccine - and this year the vaccine lagged way behind. (independentlivingnews.com)
  • A flu vaccine is only effective against the same strain of influenza virus used to develop the vaccine. (allthingshealing.com)
  • Influenza pandemics occur when a new strain of the influenza virus is transmitted to humans from another animal species. (wikipedia.org)
  • Three influenza pandemics occurred in the 20th century and killed tens of millions of people, with each of these pandemics being caused by the appearance of a new strain of the virus in humans. (wikipedia.org)
  • Often, these new strains result from the spread of an existing flu virus to humans from other animal species. (wikipedia.org)
  • Typically this vaccine includes material from two influenza A virus subtypes and one influenza B virus strain. (wikipedia.org)
  • While there can be some cross-protection against related flu strains, the best protection would be from a vaccine specifically produced for any future pandemic flu virus strain. (wikipedia.org)
  • As a consequence, the basis of influenza vaccine manufacturing is growing massive quantities of virus in order to have sufficient amounts of these protein antigens to stimulate immune responses. (wikipedia.org)
  • Influenza vaccines used in the United States and around world are manufactured by growing virus in fertilized hens' eggs, a commercial process that has been in place for decades. (wikipedia.org)
  • A universal flu vaccine is flu vaccine that is effective against all influenza virus strains regardless of the virus subtype or viral genetic drift. (wikipedia.org)
  • When asked about the prospects of a universal flu vaccine in a hearing before House Energy and Commerce Subcommittee on Oversight and Investigations, Goodman replied "Nature is very tricky and as this is a very crafty virus, so I'd be very hesitant to predict. (wikipedia.org)
  • F16 is the only known antibody that binds (its neutralizing activity is controversial) to all 16 subtypes of the influenza A virus hemagglutinin and might be the lynchpin for a universal influenza vaccine. (wikipedia.org)
  • The subdomain of the hemagglutinin that is targeted by FI6, namely the stalk domain, was actually successfully used earlier as universal influenza virus vaccine by Peter Palese's research group at Mount Sinai School of Medicine. (wikipedia.org)
  • In 2008, Acambis announced work on a universal flu vaccine (ACAM-FLU-ATM) based on the less variable M2 protein component of the flu virus shell. (wikipedia.org)
  • A viral shift is the sudden emergence of a seemingly novel strain of a virus. (wikipedia.org)
  • An existing virus undergoes a change and becomes a pathogen, such as the constantly mutating "A" strain of influenza in which the change is known as an antigenic shift. (wikipedia.org)
  • Entry into the host cell is achieved by attachment of the viral proteins to host glycosaminoglycans (GAGs) mediates endocytosis of the virus into the host cell. (wikipedia.org)
  • Mortality varies according to the virus strain (up to 60% in non-vaccinated flocks). (wikipedia.org)
  • For virus characterization, recent methodology using genomic amplification (PCR) and sequencing of products, will enable very precise description of strains, according to the oligonucleotide primers designed and target gene. (wikipedia.org)
  • It is also used to refer to naturally occurring recombination between virus genomes in a cell infected by more than one virus strain. (wikipedia.org)
  • proteins
  • Study of the generation of CD8 memory T cells against soluble proteins: A step toward a new vaccine design? (europa.eu)
  • H1N1
  • On 11 June 2009, a new strain of H1N1 influenza was declared to be a global pandemic (Stage 6) by the WHO after evidence of spreading in the southern hemisphere. (wikipedia.org)
  • virulent
  • A number of recombinants between the virulent Mahoney and attenuated Sabin 1 strains of type 1 polioviruses were constructed. (springer.com)
  • poliovirus
  • The monkey neurovirulence tests and in vitro phenotypic marker tests of these recombinant virsuses indicate that PV1/2(SS)BB and PV1/3(SS)BN are possible candidates for new strain of type 2 and type 3 oral poliovirus vaccine. (springer.com)
  • Sabin AB, Boulger LR (1973) History of Sabin attenuated poliovirus oral live vaccine strains. (springer.com)
  • Melnick JL (1984) Live attenuated oral poliovirus vaccine. (springer.com)
  • Minor PD (1982) Characterization of strains of type 3 poliovirus by oligonucleotide map ping. (springer.com)
  • Ren R, Moss EG, Racaniello VR (1991) Identification of two determinants that attenuate vaccine-related type 2 poliovirus. (springer.com)
  • Fluzone
  • According to the manufacturer's safety studies, compared to the regular Fluzone vaccine the high-dose version not only resulted in more frequent reports of common adverse reactions, it also caused slightly higher rates of Serious Adverse Events (SAE's). (care2.com)
  • A total of 6.1 percent of seniors injected with the regular Fluzone vaccine experienced a serious adverse event, compared to 7.4 percent of those receiving the high-dose version. (care2.com)
  • pandemic
  • Vaccine manufacturing companies are being encouraged to increase capacity so that if a pandemic vaccine is needed, facilities will be available for rapid production of large amounts of a vaccine specific to a new pandemic strain. (wikipedia.org)
  • However, only a single manufacturer produces the annual vaccine entirely within the U.S. Thus, if a pandemic occurred and existing U.S.-based influenza vaccine manufacturing capacity was completely diverted to producing a pandemic vaccine, supply would be severely limited. (wikipedia.org)
  • HHS will ensure the building of capacity and will engage states in a discussion about the purchase and distribution of pandemic influenza vaccine. (wikipedia.org)
  • How to best spend pandemic mitigation funds and poultry farming protection funds is a question that to be answered requires billions in flu research and new flu vaccine manufacturing factories. (wikipedia.org)
  • The federal government says its goal is to be able to distribute a vaccine to every American within six months of a pandemic. (wikipedia.org)
  • protective
  • finds that having states require the latest, most protective HPV vaccine for girls and boys would be highly cost-effective and would lead to better health outcomes at the national level. (self.com)
  • hypothesis
  • On March 12, a reporter writing for the Canadian Broadcasting Corporation called for a " legalized type of censorship ," a ban on talking about the "vaccine/autism hypothesis" because he pronounced it "the modern equivalent of falsely crying 'fire' in a crowded theatre. (blogspot.com)
  • The selection of the influenza strains that make up the vaccine is a hypothesis or guess. (allthingshealing.com)
  • 1998
  • It has been both sickening and frightening to watch physicians and some journalists engage in a relentless persecution of Dr. Andrew Wakefield, who first published research in 1998 examining the potential association between MMR vaccine and autism. (blogspot.com)
  • Before the autism-related controversy started in 1998, some concern had already arisen about the safety of the MMR vaccine due to side effects associated with the Urabe mumps strain, including rare adverse events of aseptic meningitis, a transient mild form of viral meningitis. (wikipedia.org)
  • chickens
  • Species that are thought to be important in the emergence of new human strains are pigs, chickens and ducks. (wikipedia.org)
  • Attenuated vaccines will revert to virulence by consecutive passage in chickens in densely populated areas, and may reassort with field strains, generating potentially important variants. (wikipedia.org)
  • NIAID
  • To address the H9N2 threat, NIAID contracted with Chiron Corporation to produce investigational batches of an inactivated vaccine, which will be evaluated clinically by NIAID early next year[when? (wikipedia.org)
  • antigen
  • The idea is that seniors need more antigen in order to provoke the desired immune response, because studies have found that the flu vaccine creates only a weak immune response in the elderly. (care2.com)
  • 1988
  • Nomoto A, Iizuka N, Kohara M, and Arita M (1988) Strategy for construction of live picornavirus vaccines. (springer.com)
  • Clinical
  • Dynavax have developed a vaccine N8295 based on two highly conserved antigens NP and M2e and their TLR9 agonist, and started clinical trials in June 2010. (wikipedia.org)