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  • immunology
  • Lavelle, who is Lecturer in Immunology in the School of Biochemistry and Immunology, Trinity College Dublin, said: "This is a very exciting finding and supports the development of inflammasome activating vaccines to prevent pneumococcal diseases including pneumonia and septicaemia. (medindia.net)
  • It is also a participant in the UK Paediatric Vaccine Group (UKPVG) and contributes to the Oxford University Hospitals NHS Trust's tertiary Paediatric Infectious Disease and Immunology Service. (wikipedia.org)
  • strains
  • If a protein based vaccine could be produced that can protect against all strains of the pneumococcus, this would be of tremendous value and our discovery that NLRP3 is needed for protection will point us in the right direction in terms of how to develop such vaccines. (medindia.net)
  • The vaccine, consisting of four inactivated E. coli bacterial strains and the ETEC-based B subunit protein LCTBA, was studied for safety and immunogenicity in a total of 129 healthy volunteers. (medindia.net)
  • These vaccines are produced by growing the virus in tissue cultures that will select for less virulent strains, or by mutagenesis or targeted deletions in genes required for virulence. (wikipedia.org)
  • Herpes
  • If as for an example a patient has previously been infected by a "wild type" virus like the common herpes simplex virus, using a therapy approach in the form of herpes simplex live attenuated vaccine would achieve a desired result in such a manner that symptoms of the herpes simplex disease would be partially or fully cured. (wikipedia.org)
  • As a notable mention, a live herpes zoster vaccine for therapy is already available in the present time. (wikipedia.org)
  • responses
  • All predefined primary endpoints for the study were achieved showing that the vaccine is safe, with only few and mild adverse reactions observed, and strongly immunogenic, stimulating immune responses to all vaccine components. (medindia.net)
  • Furthermore, 85 % of subjects receiving the vaccine co-administered with low dose adjuvant showed significant immune responses to all vaccine components. (medindia.net)
  • 2011 onwards: Ongoing participation in an EU Childhood Life-threatening Infectious Disease Study (EUCLIDS) work package looking at genetic responses to MenC and MenB vaccines. (wikipedia.org)
  • pneumonia
  • 2005 onwards: collaborative projects with the paediatric department of Patan Hospital in Nepal, studying children admitted to the hospital with febrile illnesses and cases of typhoid, Haemophilus influenzae type b (Hib disease) and pneumonia, and evaluating carriage of Hib disease and Streptococcus pneumoniae. (wikipedia.org)
  • H1N1
  • 2009: a study comparing the effectiveness of two new vaccines against the swine flu virus H1N1 in children and adults. (wikipedia.org)
  • disease
  • Describing the results as exciting, the researchers say it will potentially have a significant impact in the development of vaccines against pneumococcal disease. (medindia.net)
  • Research by Richard Moxon into the public health impact of Haemophilus influenzae type b (Hib) invasive disease in the UK, and efficacy studies of the Hib conjugate vaccine in UK children, led to the founding of OVG in 1994. (wikipedia.org)
  • Since then OVG has particularly specialised in research into meningococcal disease and vaccines to prevent the disease. (wikipedia.org)
  • Senior staff at OVG are periodically asked to give expert opinions on aspects of vaccines and infectious disease, especially meningococcal disease. (wikipedia.org)
  • For example the 2015 announcement that 14- to 18-year-olds in the UK are to be vaccinated against MenW disease, and the 2012 European Medicines Agency (EMA) recommendation for approval of a new meningitis B vaccine. (wikipedia.org)
  • 2006: a phase II trial of a new vaccine against MenB disease. (wikipedia.org)
  • Some can be difficult to transport due to requirement to maintain conditions (e.g. temperature) In the near future, a developed live attenuated vaccine may also be used not only to prevent a disease, but for therapeutic purposes of an existing disease. (wikipedia.org)
  • immune
  • The discovery will lead to a dramatic shift in our understanding of how the body's immune system responds to infection caused by Streptococcus pneumoniae and pave the way for more effective vaccines. (medindia.net)
  • The researchers state that this new knowledge of how the toxin interacts with the immune system will mean that new vaccines can be developed and targeted more effectively. (medindia.net)
  • result
  • In total, 75% of all vaccine recipients responded to all 5 of the primary vaccine components, a result that well exceeds the primary immunological endpoint for the study (at least 50 percent of the subjects responding to at least 4 of the primary vaccine antigens). (medindia.net)
  • clinical
  • A novel oral ETEC vaccine has been developed in Sweden and a clinical phase I-study of this vaccine has now been successfully completed. (medindia.net)
  • In addition to showing excellent safety and immunogenicity of the five-component vaccine, the results also confirm previous preclinical results as well as clinical results obtained with a prototype version of this vaccine. (medindia.net)
  • areas
  • Today there is no ETEC vaccine available on the market for use in either children or travelers in ETEC high-risk areas. (medindia.net)
  • phase
  • Researchers at University of Gothenburg Vaccine Research Institute (GUVAX) revealed that their placebo controlled phase I study of an oral, inactivated Escherichia coli diarrhea vaccine has yielded positive results. (medindia.net)
  • The trial results were successful and led to phase III trials and ultimately the licensing of the new vaccine, Bexsero, in 2013. (wikipedia.org)
  • 2014-15: a phase 1 study into a new vaccine against Ebola. (wikipedia.org)
  • time
  • This research showed that immunity waned over time, and formed part of the evidence leading to the changes in the UK MenC vaccine schedule in 2013. (wikipedia.org)
  • research
  • The Oxford Vaccine Group (OVG) is a vaccine research group within the Department of Paediatrics at the University of Oxford. (wikipedia.org)
  • OVG carries out research on vaccines to improve human health. (wikipedia.org)
  • OVG research has included: 2003: a study looking at the mid- to long-term effectiveness of the Meningitis C vaccine. (wikipedia.org)
  • In 2011, the group launched the Vaccine Knowledge Project, funded by the Oxford Biomedical Research Centre. (wikipedia.org)
  • several
  • The NHS Choices website lists the Vaccine Knowledge website as a recommended external link on several of its pages. (wikipedia.org)
  • oral
  • Study participants were randomized to receive two oral doses two weeks apart of either the vaccine alone, vaccine co-administered with an oral adjuvant in a low or a higher dose, or an inactive placebo preparation (a buffer solution). (medindia.net)
  • Disease
  • Hepatitis A virus is the most common vaccine-preventable disease in travelers, and domestic cases remain associated with recent foreign travel. (clinicalpainadvisor.com)
  • Some can be difficult to transport due to requirement to maintain conditions (e.g. temperature) In the near future, a developed live attenuated vaccine may also be used not only to prevent a disease, but for therapeutic purposes of an existing disease. (wikipedia.org)
  • Research by Richard Moxon into the public health impact of Haemophilus influenzae type b (Hib) invasive disease in the UK, and efficacy studies of the Hib conjugate vaccine in UK children, led to the founding of OVG in 1994. (wikipedia.org)
  • Since then OVG has particularly specialised in research into meningococcal disease and vaccines to prevent the disease. (wikipedia.org)
  • It is also a participant in the UK Paediatric Vaccine Group (UKPVG) and contributes to the Oxford University Hospitals NHS Trust's tertiary Paediatric Infectious Disease and Immunology Service. (wikipedia.org)
  • Senior staff at OVG are periodically asked to give expert opinions on aspects of vaccines and infectious disease, especially meningococcal disease. (wikipedia.org)
  • For example the 2015 announcement that 14- to 18-year-olds in the UK are to be vaccinated against MenW disease, and the 2012 European Medicines Agency (EMA) recommendation for approval of a new meningitis B vaccine. (wikipedia.org)
  • 2005 onwards: collaborative projects with the paediatric department of Patan Hospital in Nepal, studying children admitted to the hospital with febrile illnesses and cases of typhoid, Haemophilus influenzae type b (Hib disease) and pneumonia, and evaluating carriage of Hib disease and Streptococcus pneumoniae. (wikipedia.org)
  • 2006: a phase II trial of a new vaccine against MenB disease. (wikipedia.org)
  • 2011 onwards: Ongoing participation in an EU Childhood Life-threatening Infectious Disease Study (EUCLIDS) work package looking at genetic responses to MenC and MenB vaccines. (wikipedia.org)
  • travelers
  • The fully revised and updated 2018 edition codifies the U.S. government's most current health guidelines and information for international travelers, including pretravel vaccine recommendations, destination-specific health advice, and easy-to-reference maps, tables, and charts. (oup.com)
  • virus
  • These vaccines contrast to those produced by "killing" the virus (inactivated vaccine). (wikipedia.org)
  • These vaccines are produced by growing the virus in tissue cultures that will select for less virulent strains, or by mutagenesis or targeted deletions in genes required for virulence. (wikipedia.org)
  • several
  • The NHS Choices website lists the Vaccine Knowledge website as a recommended external link on several of its pages. (wikipedia.org)