Vaccine host parasite interactions. Medical search. Frequent questions

Malaria caused by protozoan parasites of the genus Plasmodium is the most prevalent infectious disease in tropical and subtropical regions. (nature.com)
Plasmodium knowlesi is a parasite that causes malaria in humans and other primates. (wikipedia.org)
Like other Plasmodium species, P. knowlesi has a life cycle that requires infection of both a mosquito and a warm-blooded host. (wikipedia.org)
It is most closely related to the human parasite Plasmodium vivax as well as other Plasmodium species that infect non-human primates. (wikipedia.org)
In the mid-20th century, P. knowlesi became popular as a tool for studying Plasmodium biology and was used for basic research, vaccine research, and drug development. (wikipedia.org)
Like other Plasmodium parasites, P. knowlesi has a life cycle that requires it be passed back and forth between mammalian hosts and insect hosts. (wikipedia.org)
Immature human red blood cells in the bone marrow of mice infected with the parasite Plasmodium vivax. (pasteur.fr)
By engrafting human hematopoietic stem cells into mice, a team from the Institut Pasteur, Inserm and the CNRS was able to maintain the Plasmodium vivax parasite in vivo, providing a novel model to explore therapeutic strategies. (pasteur.fr)
In this chapter, we throw light on several newly characterized protein-protein interactions between the host (humans) and parasite (plasmodium) in key processes such as hemoglobin degradation, enzyme regulation, protein export, egress, invasion, and drug resistance and further discuss their viability for development as novel chemotherapeutic targets. (intechopen.com)
In this chapter, we briefly provide a basic overview of Mosquito-Plasmodium interaction and update current knowledge of tissue-specific viz. (intechopen.com)
midgut, hemocyte, and salivary glands- molecular dynamics of Plasmodium vivax interaction during its developmental transformation inside the mosquito host, in specific. (intechopen.com)
At The Institute for Genomic Research (TIGR) I was part of the team that launched the field of parasite genomics, with the publication of the genome of several Plasmodium and trypanosomatid species, Theileria parva and Trichomonas vaginalis . (umaryland.edu)
At the Institute for Genome Sciences, University of Maryland School of Medicine, we have ongoing projects on several parasites in the phylum Apicomplexa, with a focus on the causative agents of malaria in humans (genus Plasmodium ), theileriosis in cattle and horses (genus Theileria ), human adn bovine babesiosis (genus Babesia ), and human cryptosporidiosis (genus Cryptosporidium ). (umaryland.edu)
Plasmodium falciparum 7G8 challenge provides conservative prediction of efficacy of PfNF54-based PfSPZ Vaccine in Africa. (umaryland.edu)
Strains used in whole organism Plasmodium falciparum vaccine trials differ in genome structure, sequence, and immunogenic potential. (umaryland.edu)
Plasmodium knowlesi is a zoonotic malaria parasite that has gained increasing medical interest over the past two decades. (biomedcentral.com)
This disease is caused by different species of apicomplexan parasites belonging to the genus Plasmodium . (biomedcentral.com)
Over the past few decades, healthcare professionals and general public were educated that malaria was caused by four species of human malaria parasites, namely Plasmodium falciparum , Plasmodium vivax , Plasmodium malariae , and Plasmodium ovale [ 3 ]. (biomedcentral.com)
Many of the serious symptoms of malaria occur because of the invasion and growth of the Plasmodium parasite in an infected person's red blood cells, said Dr Rogers, who is the head of WEHI's Centre for Dynamic Imaging . (edu.au)
Plasmodium falciparum secretes extracellular vesicles (PfEVs) that contain parasite-derived RNA. (bvsalud.org)
Over the last century, a great deal of effort and resources have been poured into the development of vaccines to protect against malaria, particularly targeting the most widely spread and deadly species of the human-infecting parasites: Plasmodium falciparum. (bvsalud.org)
With the development of latest transcriptomic and proteomic tools, recently a great dearth of information has been generated with respect to understanding the Plasmodium biology resulting in discovery of new vaccine candidate antigens and drug targets. (icgeb.org)
Recent successes in malaria control are threatened by drug-resistant Plasmodium parasites and insecticide-resistant Anopheles mosquitoes, and first generation vaccines offer only partial protection. (figshare.com)
In this study, we discuss host-parasite interactions at the different stages of the Plasmodium life cycle within the mammalian host and the potential for therapeutics that prevent parasite migration, invasion, intracellular growth, or egress from host cells, as well as parasite-induced pathology. (figshare.com)

Come along for this exciting programme focused on general and specialist aspects of parasitology, sponsored by our Parasites & Pathogens Special Interest Group and with discounted rates for BES members. (britishecologicalsociety.org)
Depending upon their interests, students choose courses with an emphasis on immunology and molecular virology, bacterial or viral pathogenesis, parasitology and parasite-induced diseases, or epidemiology and community health. (lsu.edu)

are obligate intraerythrocytic protozoans parasites that undergo a number of developmental stages in the vertebrate host and mosquito vectors. (icgeb.org)
History of the discovery of the malaria parasites and their vectors. (medscape.com)
The infective forms of T cruzi are contained in the feces of the insect vectors and gain entry into its mammalian hosts through contamination. (medscape.com)
This mechanism of transmission contrasts with that of the two subspecies of African trypanosomes that cause human disease, Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense , which are transmitted via the saliva of their vectors, and with the mechanism by which a nonpathogenic trypanosome found in the Americas, Trypanosoma rangeli , is transmitted to its mammalian hosts. (medscape.com)
Epimastigotes are an extracellular and noninfective form of the parasite found in the midgut of insect vectors, where they multiply by binary fission. (medscape.com)
The trypomastigote is the infective flagellated form of the parasite found in the blood of the mammalian hosts (blood trypomastigote) and in the hindgut of vectors (metacyclic trypomastigote). (medscape.com)

the description of a novel recombinant bacille Calmette-Guérin (BCG) vaccine candidate that works by over-expressing not an antigen, but a membrane-perforating enzyme (Grode 2005). (tuberculosistextbook.com)
The use of recombinant vaccines can prove a valuable strategy against coccidiosis in poultry, but better understanding of host-parasite interactions and gut microbiology is needed. (poultryhealthtoday.com)
From the application point of view, they are taken into consideration the vaccine preparations (both traditional and recombinant) as well as some examples of microbial products produced with advanced technologies. (unict.it)

it depends on parasite growth and host immunity to malaria parasites. (nature.com)
Well before the antibiotic era, knowledge of immunity was used to develop vaccines and serums to prevent and treat infectious diseases. (cdc.gov)
Hence, we evaluated the protective immunity of ME49Δ cdpk3 as a live attenuated vaccine against toxoplasmosis. (nature.com)
On the other hand, the immunological armamentarium of the host against invading parasites is described also in the light of new findings on innate and adaptive immunity. (benthamscience.com)

Understanding in better detail exactly how the parasite invades red blood cells may reveal new ways to stop this stage of the parasite life cycle, potentially leading to much-needed new therapies," she said. (edu.au)
The epimastigote form of Trypanosoma cruzi is the multiplying stage of the parasite that grows in the gut of the insect vector and also in cell-free culture medium as shown here. (medscape.com)

An Interesting chapter deals with new insights into immune diagnosis in Trypanosoma cruzi infection, while another chapter on malaria vaccines critically reviews their development since the beginning, examining the basis for failures or successes encountered in clinical trials. (benthamscience.com)
The migration of the Latin American populations to North America, Europe, Asia and Oceania has made the parasite cross the seas, so as to secure the Trypanosoma cruzi survival by means of blood transfusion and by congenital transmission from mother to offspring. (eurekaselect.com)
Chagas disease is caused by the Trypanosoma cruzi parasite. (medlineplus.gov)
Chagas disease, also known as American trypanosomiasis, is caused by infection with the protozoan parasite Trypanosoma cruzi . (medscape.com)

Now molecular methods are enabling much closer inspection of pathogen-host interactions and bridging the fields of microbiology and immunology. (cdc.gov)

Disease outcome after inoculation depends on the inherent virulence of the Leishmania strain, individual immune response, host health status and intercurrent infections, among other factors [ 13 , 14 ]. (biomedcentral.com)
Silencing the 100-day Cough: Using AMD technologies to understand changes in virulence of Bordetella pertussis and find effective vaccine components and diagnostic markers (web page) OAMD, Mar 1, 2017. (cdc.gov)
For example, the authors of a recent article suggested that tolerance-based treatment of HIV infection -focused on increasing the infected patient's ability to remain well despite high HIV load (host tolerance) rather than reducing viral load (host resistance)-could be "evolution-proof," although evolution of the virus toward greater virulence remains a possibility. (cdc.gov)

Capture-based enrichment method reveals extremely high genome-wide sequence diversity in Theileria parva , an intracellular pathogen of host lymphocytes. (umaryland.edu)
We further demonstrate that the phases of RNA secreted via extracellular vesicles are discernibly shifted compared to those of the intracellular RNA within the secreting whole parasite. (bvsalud.org)
Toxoplasma gondii ( T. gondii ) is a common zoonotic intracellular parasite capable of infecting almost all warm-blooded animals, including humans 1 . (nature.com)
It is an obligate intracellular parasite that can't be cultivated on artificial medium. (cdc.gov)

New research approaches have highlighted host as well as parasite molecules or pathways that could be targeted for interventions. (figshare.com)
Among several groups of helminth molecules involved in the host-parasite interplay, protease inhibitors have been the subject of intense investigations due to their roles in a range of fundamental molecular processes, including regulation of host proteases and modulation of the host's immune response [ 18 ]. (biomedcentral.com)
These studies have identified possible parasite molecules for vaccine development. (mit.edu)

Studies to understand the immunological and molecular basis of host parasite interaction. (icmr.nic.in)
The new identification technologies and study of microorganisms are also addressed (genomes, metagenomes, proteomes etc) as well as the basics of the interaction host parasite including immunological aspects. (unict.it)

The bone marrow of these mice is capable of producing human blood cells, including red blood cells that are targeted by the parasites," explains Sylvie Garcia, a group leader in the Biology of Host-Parasite Interactions Unit . (pasteur.fr)
I am interested in the infection biology of protozoan parasites of livestock. (ed.ac.uk)
Ongoing projects include the ( i ) the study of species biology and the nature of host-parasite interactions, based on comparative genomics and ( ii ) studies of speciation, drug resistance, vaccine efficacy and vaccine design, informed by population genomics data. (umaryland.edu)
During the last decade, next generation sequencing has revolutionized our awareness in basic parasite molecular biology, its ecology and epidemiology knowledge. (fapesp.br)
The research has provided critical new information about malaria parasite biology that may have applications for the development of much-needed new antimalarial medicines. (edu.au)
The Broad Institute's Genomic Center for Infectious Diseases (GCID) was established in 2014 by the National Institute of Allergy and Infectious Diseases (NIAID) to to apply innovative genomic technologies to address fundamental gaps in our knowledge of the basic biology that underlies the interactions between hosts and pathogens. (broadinstitute.org)
The Parasite and Vector Genomics group applies genomic and transcriptomic sequencing data to profile variation among individuals and divergence among species to understand the basic biology underlying vector-borne disease transmission, with a focus on malaria. (broadinstitute.org)

However, currently B. thuringiensis is considered as a bacterium antagonistic of parasites used in investigations in vitro and in vivo therapeutic in laboratory and farm animals [3, 4]. (fortunepublish.com)
The book concludes with a review of new therapeutic approaches to combat helminth parasites (biotherapy, vaccines and natural products). (benthamscience.com)

Background Protozoan parasites are known to attach specific and diverse group of proteins to their plasma membrane via a GPI anchor. (univ-reims.fr)

Furthermore, some genera of microbiota correlated with parasite growth and/or ECM development. (nature.com)
Therefore, the elucidation of host protective mechanisms against malaria and parasite-host interactions is essential to strategies to control malaria, including vaccine development. (nature.com)
Owing to unique biological differences such as the preference for invading reticulocytes, early maturation of sexual stages during the infection, the formation of hypnozoites, unavailability of in-vitro culture, the molecular relation of P. vivax development inside the mosquito host is poorly known. (intechopen.com)
My work aims to identify key host-parasite interactions that determine disease outcome, further our understanding of bovine immunobiology, and identify targets for interventions (e.g. drug & vaccine development). (ed.ac.uk)
Research fellows from ICGEB member states working in the field of infectious diseases and drug/vaccine development will be selected from all the applications. (icgeb.org)
Vaccine Development and Therapies, and for International Journal of Veterinary Medicine: Research & Reports. (symbiosisonlinepublishing.com)
Lastly, research on drug and vaccine development exploded. (tuberculosistextbook.com)
Although most malaria research has focused on parasite development in the human host, the life cycle within the vector is critical for the propagation of the disease. (bvsalud.org)
Furthermore, it is in the vector, where sexual recombination occurs generating "de novo" genetic diversity, which can favor the spread of drug resistance and hinder effective vaccine development. (bvsalud.org)
Despite relentless efforts devoted to vaccine and drug development, adequate tools to treat and prevent most of these diseases are still lacking. (bvsalud.org)
However, the development of an effective toxoplasmosis vaccine in humans remains a challenge to date. (nature.com)
Thus, the development of an effective toxoplasmosis vaccine is critical for limiting the infection of various Toxoplasma strains. (nature.com)
Development of HIV-AIDS vaccine and clinical trials. (icmr.nic.in)
Development of combined HIV-TB vaccine. (icmr.nic.in)
Research and development of leishmania vaccine. (icmr.nic.in)
These data may be very valuable for future vaccine development. (pasteur.fr)
An investigation into schistosome digestive tract development reveals that the oesophageal gland, a site of protein secretion and entrance to the gut, could be a key organ for host immune system evasion and a site of substantial host-parasite interactions. (biomedcentral.com)
Our research has led to the discovery of a mosquito-based malaria transmission-blocking vaccine (TBV) candidate (the AnAPN1 TBV), which has recently completed process development studies and is under consideration for First-In-Human trials in the near future. (dinglasanlab.org)
This platform will be used for vaccine development against malaria parasites and African Swine Fever Virus (ASFV). (mit.edu)

This is a major breakthrough for a pathogen that cannot be cultured long term in vitro and will prove useful for testing new drug and vaccine candidates. (pasteur.fr)
The main objective of the event is to acquaint the participants with new approaches discover effective drugs and vaccine candidates for major infectious diseases, Malaria and tuberculosis. (icgeb.org)
New vaccine candidates on the horizon? (biomedcentral.com)
Because of their immunogenic properties, some of these proteins have been considered as malaria vaccine candidates. (univ-reims.fr)

These bacteria might cause secondary infections to animals, so the parasite can become a vector of pathogenic bacterial, reason why the understanding of the 'bacteria-parasite interaction" is important to combating of parasitic infestations. (fortunepublish.com)
Some parasitic diseases, such as malaria, require two hosts to complete their lifecycle: a human and an insect vector. (bvsalud.org)
However, understanding of vector-parasite interactions is hampered by the lack of experimental systems that mimic the natural environment while allowing to control and standardize the complexity of the interactions. (bvsalud.org)
Finally, we emphasize the necessity to develop robust and accessible ex vivo systems (tissues and organs) to enable investigation of the molecular mechanisms of parasite-vector interactions providing new targets for malaria control. (bvsalud.org)
We were the first to provide proof of concept demonstrations of the potential utility of mosquito based TBVs to control both human malaria parasite species ( P. falciparum and P. vivax ) in diverse anopheline vector species across the globe. (dinglasanlab.org)
Combining pathogen genome sequences with the host and vector genome sequences is promising to be a robust method for the identification of host-pathogen interactions. (nyu.edu)
Via collaborations with academic and industry partners, we explore the evolutionary basis of drug and insecticide resistance, develop new methods of generating and applying genomic data in parasite and vector systems, and identify the genetic determinants of vaccine efficacy. (broadinstitute.org)

The present study presents a genome-wide microarray transcript analysis of 18 P. falciparum parasite isolates freshly collected from the placenta. (pasteur.fr)

In malaria parasites, GPI-anchored proteins (GPI-APs) have been shown to play an important role in host-pathogen interactions and a key function in host cell invasion and immune evasion. (univ-reims.fr)

One such 'noneradication outcome' was the impetus that the members of the ITFDE gave to initiating a demonstration project to control intestinal parasites among schoolchildren in Ghana. (cdc.gov)
So, it is of paramount importance to address the symbiosis and relationship that develop the bacteria with the intestinal parasites of pets and production animals by the side effects that can cause in animal health. (fortunepublish.com)

For example, this information is important to define the resistance or susceptibility against certain diseases and/or the influence of parasites on the genetic repertoire of an endangered primate species. (bprc.nl)
Many species of freshwater snails have been reported as intermediate hosts of highly infective fluke (trematode) larvae of the genus Schistosoma which cause schistosomiasis also known as bilharziasis. (oap-bioscience.org)
Urinary schistosomiasis, caused by Schistosoma haematobium which has a suitable snail host species of aquatic freshwater Bulinus snails, is one of the neglected tropical diseases very common in Nigeria, with some States having very high prevalence especially in the southeastern part of the country 12 , 13 . (oap-bioscience.org)
Finally, comparative sequencing of related species, especially of organisms used as model systems in the study of the disease, is beginning to realize its potential in the identification of genes, and the evolutionary forces that shape the genes, that are involved in evasion of the host immune response. (nyu.edu)

We also found that mice infected with the rodent malaria parasite P. yoelii 17XNL succumbed to otherwise non-lethal infection when mice were co-infected with an intestinal helminth Heligmosomoides polygyrus 10 . (nature.com)
I am particularly attracted to integrated approaches where we can learn about both host and parasite processes that are key to infection/disease progression - especially in the clinically relevant host, the cow. (ed.ac.uk)
In the study reported here, we explored the relationship between the intestinal microbiome and infection with L. infantum in this surrogate host. (biomedcentral.com)
Domestic and other wild cats are the definitive hosts of T. gondii , and ingestion of oocysts excreted by cats is the main source of infection in intermediate hosts (humans and animals) 1 , 8 . (nature.com)
The aim of the course is that the student should have acquired knowledge, proficiencies and abilities on completion of the course concerning both pathogenic microorganisms and the function of the immune system at the molecular and cellular level, and understand host-pathogen interactions and infection processes from both a mechanistic and an evolutionary perspective. (lu.se)
The course covers pathogenic microorganisms, the function of the immune system, host-pathogen interactions and infection processes from a mechanistic and an evolutionary perspective. (lu.se)

Genomic technologies are providing infectious disease researchers an unprecedented capability to study at a genetic level the viruses that cause disease and their interactions with infected hosts. (broadinstitute.org)

The parasite infections of animals (production and pets) affect the health and quality of animal life, the parasites frequently present a microbiome associated which play several functions, like nutrition, reproduction or defense against the host immune system, and in some cases are opportunistic microorganisms. (fortunepublish.com)
Although the interaction between the intestinal microbiome and the immune response has been established in several pathologies, it has not been widely studied in leishmaniasis. (biomedcentral.com)
The human microbiome has an important role in protecting the human host against colonization by harmful invaders and keeping their numbers in check. (cdc.gov)

This entailed mining available transcriptomic and/or genomic sequence datasets for the presence of homologues of known TIMPs, predicting secondary structures of defined protein sequences, systematic phylogenetic analyses and assessment of differential expression of genes encoding putative TIMPs in the developmental stages of A. suum , N. americanus and Schistosoma haematobium which infect the mammalian hosts. (biomedcentral.com)
As with other parasites that infect both mammalian and insect hosts, the life cycle of T cruzi is complex (see image below). (medscape.com)

While the natural warm-blooded hosts of P. knowlesi are likely various Old World monkeys, humans can be infected by P. knowlesi if they are fed upon by infected mosquitoes. (wikipedia.org)
While the parasite can be observed in the bloodstream, it is also found in the bone marrow, which is a reservoir in humans for P. vivax human-to-mosquito transmission stages. (pasteur.fr)
In addition, experimental infections on humans that gave rise to symptoms were described, providing the first recorded proof of pathobiological effects cast by this simian parasite to humans [ 10 ]. (biomedcentral.com)
The infections of P. knowlesi in humans are considered as accidents in the life cycle of this parasite. (biomedcentral.com)
Because of this, armadillos rapidly became the hosts-of-choice for in vivo propagation of leprosy bacilli, and, since armadillos and humans are the only hosts that can develop extensive neurological involvement with M. leprae, they're leading models for piloting new therapies and diagnostics. (cdc.gov)
Infected insects take blood meals from humans and their domestic animals and deposit parasite-laden feces. (medscape.com)

Most antimalarial therapies and vaccines target the initial binding of malaria to red blood cells. (edu.au)

Antimicrobial resistance has also emerged in viruses, fungi, and parasites. (cdc.gov)
Her graduate studies examined host-pathogen interactions of influenza viruses. (bvgh.org)

attack a vital bacteria of parasites through antibiotics possibly can be a control alternative, at the same way, the use of bacteria capable to control to parasitic diseases by antagonist interaction, like lethal toxins or adhesion at the site invasion of the parasites, are alternatives to explore. (fortunepublish.com)
The research has revealed key steps in the parasite invasion process, which is a critical point of the malaria life-cycle and underpins many symptoms of malaria. (edu.au)
Ms Evelyn, who began the research as an Honours student, said the research revealed many previously unrecognised aspects of parasite invasion. (edu.au)
LLSM may also have applications for observing the specific steps of parasite invasion that are blocked by potential new drugs - an area we are now very interested in pursuing. (edu.au)
In parasitic helminths, such as hookworms, TIMPs have been proposed to play key roles in the host-parasite interplay, including invasion of and establishment in the vertebrate animal hosts. (biomedcentral.com)

This gap in our knowledge comes from the fact that these parasites have complex life cycles, during which they infect a variety of specific cell types that are difficult to access or model in vitro. (bvsalud.org)
Jensen and collaborators showed that strains from different genotypes can infect the same host repeatedly 14 . (nature.com)

Like other major infectious diseases in human history, the cost-effective and sustainable control of major infectious diseases will depend on effective vaccines. (mit.edu)

the nutritional role, immunomodulating property, and contribution to the pathogenesis [5-7], at the same time, the enteric helminths can increase or decrease the beneficial bacterial populations in the host, affecting the health of the animal [8]. (fortunepublish.com)
These findings suggest that other parasite proteins, such as PFI1785w, may contribute beside VAR2CSA to the pathogenesis of PAM. (pasteur.fr)
To develop an effective vaccine, it is critical to identify immunogens and protection correlates, which requires thorough understanding of host and pathogen interaction and disease pathogenesis. (mit.edu)

Understand the bacteria-parasite interaction will help us to the control of parasitic diseases in an integral form, as well know as the bacterial infections that can develop from the parasitic infestation. (fortunepublish.com)

We are developing an mRNA-based vaccine platform that is streamlined and validated in i) antigen identification and design, ii) targeted delivery of vaccine mRNA into the dendritic cells (DCs) for inducing potent immune responses, and iii) selection of adjuvants for enhanced neutralizing antibody response. (mit.edu)

This volume covers research on the interaction of major helminth parasites with the immune system. (benthamscience.com)

Protein-protein interactions (PPIs), an integral part of host-pathogen cross-talk and parasite survival, have only recently emerged as promising drug targets. (intechopen.com)

Therefore, it is likely that immune responses evoked in intestines may affect host defense mechanisms to malaria. (nature.com)
As part of the Singapore-MIT Alliance for Research and Technology (SMART), we have identified cellular and molecular mechanisms by which dengue virus and malaria parasites interact and evade the host immune system. (mit.edu)

Occasionally, parasites that invade red blood cells instead enter a sexual cycle, developing over approximately 48 hours into distinct sexual forms called microgametocytes or macrogametocytes. (wikipedia.org)
State-of-the-art video microscopy has enabled WEHI researchers to see the molecular details of how malaria parasites invade red blood cells - a key step in the disease. (edu.au)
As the host cells rupture, the trypomastigotes are released into the lymphatics and bloodstream, through which they spread to distant sites and invade new host cells. (medscape.com)

Malaria cysteine proteases have been shown to be immunogenic and are being exploited as serodiagnostic markers, drug and vaccine targets. (unl.pt)

Using proteome and protein-protein interaction approaches, we have illustrated an important complex referred as haemoglobin degradation & Hz formation complex (Degradosequestrasome). (icgeb.org)

The videos we recorded showed the 'push and pull' interactions as the parasite landed on the red blood cell, and then entered the cell in an enclosed chamber - called a vacuole - where it grew and multiplied.There has long been contention in the field about whether the vacuole is derived from the parasite or the host cell. (edu.au)
For example, now that we know that the parasite vacuole relies on components of the red blood cell membrane, it might be possible to target these components with medicines to disrupt the parasite life cycle. (edu.au)
Falcipain-2 and falcipain-3 act in concert with other proteases to hydrolyze host erythrocyte hemoglobin in the parasite food vacuole. (unl.pt)

A major focus is the evolution and spread of bacterial pathogens (and antibiotic resistance) including the interactions that these pathogens have with their host and host-associated microbiota. (broadinstitute.org)

Coccidiosis is a ubiquitous challenge for poultry producers, with Eimeria parasites that cause the disease adapted to thrive under poultry house conditions. (poultryhealthtoday.com)
According to Waldrip, Zoamix is unique in that it's a synthetic compound but works similarly to an ionophore by allowing some cycling of Eimeria, the parasite that causes coccidiosis. (poultryhealthtoday.com)

The interaction between polymorphonuclear leukocytes (PMN) or neutrophils and Leishmania became an interesting focus of research, since PMN turn out to be essential cells in transiently hosting the parasites. (unl.pt)

however, the emerging threat of drug resistance and suboptimal vaccine efficacies threaten global eradication efforts. (intechopen.com)
This host-directed approach could be one way to bypass the malaria parasite's propensity to rapidly develop drug resistance," Dr Rogers said. (edu.au)

Immunogenomic profile at baseline predicts host susceptibility to clinical malaria disease. (umaryland.edu)

The genome contains two large gene families that are unique to P. knowlesi: the SICAvar (schizont-infected cell agglutination variant) family, which is involved in displaying different antigens on the parasite surface to evade the immune system, and the Kir (knowlesi interspersed repeat) family, involved in adhering parasitized red blood cells to blood vessel walls. (wikipedia.org)

To reconstitute interactions between P. vivax and its human host more effectively, the scientists worked on mice engrafted with human hematopoietic stem cells. (pasteur.fr)
The model recreates the P. vivax blood stage, which coincides with the onset of symptoms in patients and during which the parasite is transmitted to mosquitoes. (pasteur.fr)
By producing immature red blood cells in the bone marrow at the stage when they are infected by P. vivax , these mice provide an in vivo model in which the parasite can be maintained. (pasteur.fr)

Finally, transcripts of genes with no known function during the asexual intraerythrocytic developmental cycle are enriched in PfEVs compared to the whole parasite. (bvsalud.org)
Freshwater snails are considered to be intermediate hosts because the sexual stages of the parasites are found in man while the snails harbour the asexual stage 1 , 2 , 3 , 4 . (oap-bioscience.org)

In 2007, He moved to Australia after accepting a position at Department of Primaries Industries and Fisheries (DPIF), Queensland, as the lead scientist on a tick vaccine research program. (symbiosisonlinepublishing.com)

Even in those cases when host cells are readily available, these are generally terminally differentiated and difficult or impossible to manipulate genetically, which prevents assessing the role of human factors in these diseases. (bvsalud.org)

Former director of the PATH Malaria Vaccine Initiative, Christian Loucq, M.D., says it is exciting to see Dinglasan's concept moving toward a clinical trial. (dinglasanlab.org)

There are no vaccines or medicines to prevent Chagas disease. (medlineplus.gov)

The Syrian hamster is the most advanced laboratory model for developing vaccines and new drugs against VL. (biomedcentral.com)

These data demonstrated that ME49Δ cdpk3 inoculation induced effective cellular and humoral immune responses against acute and chronic Toxoplasma infections with various strains and was a potential candidate to develop a vaccine against toxoplasmosis. (nature.com)

Subsequently, this parasite was successfully isolated and maintained in vivo using monkeys [ 9 ]. (biomedcentral.com)

In the present study, we conducted a large-scale investigation of TIMP proteins of a range of neglected human parasites including the hookworm Necator americanus , the roundworm Ascaris suum , the liver flukes Clonorchis sinensis and Opisthorchis viverrini , as well as the schistosome blood flukes. (biomedcentral.com)

Organisms7

Chemicals and Drugs13

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes1

Disciplines and Occupations1

Information Science1

Health Care1

Plasmodium24

Parasitology2

Vectors6

Recombinant3

Immunity4

Stage of the parasite2

Trypanosoma4

Microbiology1

Virulence3

Intracellular4

Molecules3

Immunological2

Biology7

Therapeutic2

Protozoan1

Development19

Candidates4

Vector7

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Immune evasion1

Intestinal parasites2

Species4

Infection6

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Humans6

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Invasion5

Infect2

Infectious1

Pathogenesis3

Parasitic Diseases1

Antigen1

Helminth1

Survival1

Mechanisms2

Invade3

Targets1

Approaches1

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Eimeria2

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Susceptibility1

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