Vaccine antigens tumor associated carbohydrate. Medical search. Frequent questions

6. Induction of IgG antibodies against the GD2 carbohydrate tumor antigen by vaccination with peptide mimotopes. (nih.gov)
Examples include the use of lipid A derivatives or entirely carbohydrate vaccine conjugates such as Globo H-PS A1 Globo H-targeting antibodies are another strategy currently being evaluated in the cancer therapeutic space. (wikipedia.org)
Understanding this process is critical for developing monoclonal antibodies, designing effective vaccines, and understanding autoantibody formation. (nih.gov)
We propose (2a) to test anti-ovarian TVM antibodies as diagnostic tools and, (2b) to couple anti-ovarian TVM antibodies with toxic nanoparticles and test them as immunotherapeutics using the ESC ovarian tumor model. (nih.gov)
The way the vaccine works is that it inserts DNA into the patient's cells and produces antibodies and T-cells for the target cells. (escovaccixcell.com)
Important methods of immunotherapy in cancer involve the use of cytokines, monoclonal antibodies, cancer vaccines and immunogene therapy. (researchandmarkets.com)
Monoclonal antibodies can be used for the delivery of anticancer payloads such as radionucleotides, toxins and chemotherapeutic agents to the tumors. (researchandmarkets.com)
She is particularly interested in the immunological foundation of anti-carbohydrate antibodies, their effects on cancer and heart diseases, and the development of innovative diagnostics and treatments for these diseases. (glycanage.com)
Antibodies produced in response to a foreign antigen are characterized by polyclonality, not only in the diverse epitopes to which their variable domains bind but also in the various effector molecules to which their constant regions (Fc domains) engage. (nature.com)
Pairing drugs with antibodies to better direct them to tumors is a familiar concept, as seen by the rapid growth of the antibody-drug conjugate market. (drugdiscoverynews.com)
In autoimmune conditions, the body produces autoantibodies, which are antibodies that target and attack the self-antigens. (microbiologynote.com)
The immune system produces antibodies or immune cells (such as T cells) that specifically bind to the antigenic epitopes on the surface of the antigen. (microbiologynote.com)
This binding occurs through molecular interactions between the antigen and the antigen receptor of immune cells or antibodies. (microbiologynote.com)
At present, it's hard to produce antibodies against these molecules because the immune system is generally poor at reacting against carbohydrates, and TACAs are not usually seen as foreign bodies. (labiotech.eu)
For instance, R&D Systems offer a wide range of reagents for culturing natural killer cells and investigating natural killer cell and tumor cell interactions and various other components such as recombinant proteins, blocking/neutralization antibodies, fluorochrome-conjugated antibodies and ELISA Kits. (openpr.com)

2. Cancer vaccine with mimotopes of tumor-associated carbohydrate antigens. (nih.gov)
Globo H (globohexaosylceramide) is a globo-series glycosphingolipid antigen that is present on the outer membrane of some cancer cells. (wikipedia.org)
Globo H's biosynthetic pathway is involved in the synthesis pathways of other globo-series glycosphingolipid antigens that are also specific to cancer cells, including stage-specific embryonic antigen-3 (SSEA3) and stage-specific embryonic antigen-4 (SSEA4). (wikipedia.org)
Playing a part in the formation of three different cancer-specific antigens, β3GalT5 is of particular interest in its relevance to cancer treatment, and it has been shown to be critical for cancer cell survival. (wikipedia.org)
While absent in normal tissues, the glycosphingolipid is overexpressed in a variety of epithelial cancer cell types including human pancreatic, gastric, lung, colorectal, esophageal, and breast tumors. (wikipedia.org)
The Phase III GLORIA study is underway evaluating the carbohydrate-based immunogen's effects in high risk triple-negative breast cancer (TNBC) patients with an estimated completion date in 2027. (wikipedia.org)
and (iii) a carbohydrate domain thought to be responsible for the accumulation of bleomycin in some cancer cells. (bvsalud.org)
Tumor specific expression, expression at the earliest stages of tumor development, and direct exposure to blood, suggest that TVMs are ideal biomarkers for both ovarian cancer diagnosis and targeted immunotherapy. (nih.gov)
We therefore propose (3) to isolate ovarian tumor stem cells and grow them in vivo using the ESC ovarian cancer model. (nih.gov)
Targeting immune responses to truncated variants of O-glycan chains expressed by tumour cells represents a promising approach for the development of antigen-specific therapeutic vaccines against cancers, and accumulated evidence has rendered Tn a prime target for cancer immunotherapy. (sussex-research.com)
How Do Cancer Vaccines Work? (escovaccixcell.com)
A cancer vaccine is a form of immunotherapy that helps the immune system to be familiar with and recognize cancer cells. (escovaccixcell.com)
The development of cancer vaccines to prevent or treat cancer is more difficult compared to other types of vaccines. (escovaccixcell.com)
Cancer vaccines designed to treat and prevent cancer are more difficult to develop and produce compared to other types of vaccines. (escovaccixcell.com)
Additionally, there are instances where the tumors of each cancer patient are unique. (escovaccixcell.com)
This results in a more refined and targeted approach to developing effective cancer vaccines. (escovaccixcell.com)
There are two types of cancer vaccines. (escovaccixcell.com)
Cancer vaccines were made to reduce risks. (escovaccixcell.com)
More studies have been put into therapeutic vaccines for curing cancer, one of which is NeuVax . (escovaccixcell.com)
Because of this, it is still possible for someone to take the prophylactic vaccine and still be diagnosed with cervical cancer. (escovaccixcell.com)
Considering this, there are new developments in the field of therapeutic vaccines for cervical cancer which might prove to be more effective with fewer side effects. (escovaccixcell.com)
It is a form of DNA vaccine that is now in Phase II testing for the treatment of cervical cancer. (escovaccixcell.com)
Small interfering RNAs (siRNAs) can be targeted to tumors and one example is the suppression of H-ras gene expression indicating the potential for application in therapy of ovarian cancer. (researchandmarkets.com)
Nucleic acid-based cancer vaccines are also described. (researchandmarkets.com)
The lab specializes in reproductive and cancer biology, with an emphasis on the investigation of novel signaling pathways that contribute to the pathology of benign gynecologic diseases, malignant transformation, and the contribution of cancer stem cells to the pathology of ovarian and uterine tumors. (massgeneral.org)
A major effort in the Rueda laboratory has been to identify and functionally characterize inherent and acquired mechanisms that contribute to metastasis, resistance, and recurrence of gynecological cancers to better inform the development and testing of novel or repurposed drugs that can target both cancer stem and non-stem tumor cells. (massgeneral.org)
This rich resource serves to support our investigators whose research is focused on developing or improving early diagnostics, defining molecular pathways contributing to the genesis of the tumors, developing pre-clinical models for testing of novel anti-cancer therapies and or combination drug strategies including primary derived organoids and xenografts, and discerning mechanisms contributing to inherent and acquired treatment resistance. (massgeneral.org)
National Cancer Institute 1 Introduction 1 Clinical investigations 3 Origins of the cancerous state 4 Development of clinical cancer 5 Autonomy 5 Spread of cancer 6 Wound washings 6 Cancer cells in circulating blood 7 Spread of tumor in animal models. (nih.gov)
Cancer cells can carry both self antigens as well as what are referred to as cancer-associated antigens. (blogspot.com)
Cancer-associated antigens mark cancer cells as abnormal or foreign and can cause killer T cells to mount an attack against them ( 1 - 7 ). (blogspot.com)
Many cancer-associated antigens are only slightly altered versions of self antigens and therefore may be hard for the immune system to recognize. (blogspot.com)
Cancer cells may undergo genetic changes that may lead to the loss of cancer-associated antigens. (blogspot.com)
Pancreatic cancer is the most common lethal tumor in America. (mdpi.com)
Many studies have focused on carbohydrates that increase in cancer cells, but only a few have looked at carbohydrates that appear in normal cells but decrease or disappear in cancer cells. (sbpdiscovery.org)
When core 3 O-glycans were forced to express on human prostate cancer cell lines, those prostate cancer cells produced much smaller tumors and almost no metastasis. (sbpdiscovery.org)
By contrast, the parent cancer cells, which did not express core 3 O-glycans, produced robust primary and metastatic tumors. (sbpdiscovery.org)
From hijacking the vascular system to feed tumors and camouflaging itself from immune checkpoints, to evolving to develop resistance to previously effective drugs, cancer has dozens of ways to evade treatment. (drugdiscoverynews.com)
A type of tumor that is benign (not cancer). (nih.gov)
The German startup Tacalyx has raised €7M in a seed round to fund the preclinical development of first-in-class carbohydrate-targeting antibody drugs for the treatment of cancer. (labiotech.eu)
Saeland E, Belo A.I., Mongera S., van Die I, Meijer GA and VAN KOOYK Y. Differential glycosylation of MUC1 and CEACAM5 between normal mucosa and tumour tissue of colon cancer patients. (dc4u-technologies.nl)
Tumor markers are indicators of cancer in the blood. (healthline.com)
While doctors don't typically use tumor markers as part of screening, research shows tumor marker testing could be helpful in tracking treatment and predicting outlook for people with cancer. (healthline.com)
This article will discuss which tumor markers might suggest cervical cancer, how doctors might interpret test results, and the limitations of those results. (healthline.com)
In some people, their cancer cells make the tumor marker. (healthline.com)
Some tumor markers are associated with one specific type of cancer. (healthline.com)
Not all types of cancer have known tumor markers. (healthline.com)
What are the tumor markers for cervical cancer? (healthline.com)
Various studies have identified different tumor markers that commonly appear with cervical cancer . (healthline.com)
SCCA is an antigen present in the SCC subtype of cervical cancer. (healthline.com)
The global natural killer cells market is highly competitive and fragmented, though companies are investing of specific therapy using natural killer cell products to be used in immune-oncology to treat cancer and other tumors. (openpr.com)
The fact that mutations can cause cancercells to produce proteins or other molecules that are known to the body forms the theoretical basis for therapeutic cancer vaccines. (iprojectmaster.com)
Cervical vertebrae 1,2, …?Ca: Calcium?Ca: Cancer?Ca: Carcinoma?Ca: Cardiac arrest?Ca: Coronary artery?CA-125: A tumor marker for ovarian cancer?CAB: Cellulose acetate butyrate?CABG: Coronary artery bypass graft?CACI: Computer-Assisted Continuous Infusion?CAD: Coronary artery disease?CAG: ?CAH: Chronic active hepatitis?CAH: Congenital adrenal hyperplasia?calid. (kuwaitpharmacy.com)
This critical factor may lead to the development of non-invasive diagnostic tests, innovative treatments and cancer vaccines. (biomedcentral.com)
Can the highly site specific colonization of certain bacteria for a tumor be clinically useful in the diagnosis of cancer or delivery of a therapeutic agent? (biomedcentral.com)
Recent findings that have found associations between certain bacterial infections and tumor development will be discussed as well as genetic factors that may predispose individuals to "cancer- causing" infections. (biomedcentral.com)

3. DNA vaccine expressing the mimotope of GD2 ganglioside induces protective GD2 cross-reactive antibody responses. (nih.gov)
17. Molecular characterization of the anti-idiotypic immune response of a relapse-free neuroblastoma patient following antibody therapy: a possible vaccine against tumors of neuroectodermal origin? (nih.gov)
Globo-H's TACA character allows for its utilization as an anticancer vaccine, inducing antibody response against the epitope. (wikipedia.org)
OBI Pharma's OBI-888 is a humanized IgG1 antibody that selectively binds to the Globo H antigen among other Globo series glycosphingolipids such as SSEA-3 and SSEA-4. (wikipedia.org)
Moreover, we show that agonistic CD40 antibody combined with MF59 (AddaVax) emulsion synergistically improves the antigen-specific T cell response of the AMAX in vivo. (eur.nl)
A measure of the binding strength between antibody and a simple hapten or antigen determinant. (lookformedical.com)
It depends on the closeness of stereochemical fit between antibody combining sites and antigen determinants, on the size of the area of contact between them, and on the distribution of charged and hydrophobic groups. (lookformedical.com)
It includes the concept of "avidity," which refers to the strength of the antigen-antibody bond after formation of reversible complexes. (lookformedical.com)
the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. (lookformedical.com)
Produced by white blood cells, an antibody is a Y-shaped protein that marks antigens for destruction by immune cells. (microbiologynote.com)
A complex of antigen and antibody is formed when an antibody binds to an antigen. (microbiologynote.com)
The formation of an antigen-antibody complex provokes an immune response against the foreign substance. (microbiologynote.com)
Tacalyx will use the money to generate a lead candidate antibody for the treatment of solid tumors, and fund animal studies of the drug over the next 18 months. (labiotech.eu)
TACAs help the tumor to grow and suppress the immune system, so blocking them with antibody drugs has the potential to kill the tumors they are attached to. (labiotech.eu)
Hcv is mostly derived from a human leukocyte antigen hla and neutrophil-specific, cytomegalovirus cmv or rubella antibody titers. (elastizell.com)

As a Tumor Associated Carbohydrate Antigen (TACA), Globo-H is a promising clinical target for immunotherapy. (wikipedia.org)
Tumor-Associated Carbohydrate Antigen (TACA). (sussex-research.com)

Carbohydrates - namely glycans - decorate every cell in the human body and most secreted proteins. (nih.gov)
During oncogenesis, the cell-surface glycans on tumor cells are transformed relative to the normal phenotype through modified expression of the enzymes involved in the cell's glycoprocessing machinery. (nih.gov)
The binding between tumors and other cell types is often mediated by carbohydrate-protein (lectin) interactions involving the aberrant glycans expressed on tumor cells. (nih.gov)
In addition, some of these tumor cell glycans are TACA's that are recognized as non-self by the immune system and have thus been used as components in vaccine constructs that are in clinical trials. (nih.gov)
Most recent studies in Dr. Fukuda's laboratory revealed that decrease of the laminin-binding glycans on α-dystroglycan in carcinoma cells leads to tumor cell migration, invasion, and metastasis. (sbpdiscovery.org)
The results indicate that certain carbohydrates on normal cells and enzymes that synthesize those glycans, such as β3-N-acetylglucosaminyltransferase, function as tumor suppressors These findings will be useful in developing carbohydrate-based therapy for the treatment of inflammation and tumor metastasis. (sbpdiscovery.org)
A specific mucin-type O-glycans (core 3 O-glycans) is one of such glycans, and we found core 3 O-glycans suppress tumor formation and metastasis. (sbpdiscovery.org)
We also revealed tumor suppressor function in the unique laminin-binding glycans on dystrophin complex, -- carbohydrates located on α-dystroglycan, which is also associated with cell adhesion. (sbpdiscovery.org)
Restoration of the laminin-binding glycans by forced expression of β3-N-acetylglucosaminyltransferase, on the other hand, results in reduced cell migration, thus dramatic decrease in tumor formation and metastasis. (sbpdiscovery.org)
We demonstrated that interaction of laminin with the unique glycans on α-dystroglycan counteracts the cell migration signals that are mediated by integrin binding to its ligands, thereby decreasing tumor formation and metastasis. (sbpdiscovery.org)
These results indicate that certain carbohydrates on normal cells and enzymes that synthesize those glycans, such as β3-N-acetylglucosaminyltransferase, function as tumor suppressors. (sbpdiscovery.org)
Aarnoudse CA, Vallejo JJ, Saeland E and VAN KOOYK, Y. Recognition of tumor glycans by antigen-presenting cells. (dc4u-technologies.nl)

Cite this: Randomized Clinical Studies of Anti-tumor Vaccination: State of the Art in 2008 - Medscape - Jan 01, 2009. (medscape.com)
Hence, we provide pre-clinical support for the induction of effector CD8+ T cells through the adaptable AMAX platform as easy implementable peptidic vaccination strategy against any antigen of choice, including neoantigens for anti-tumor immunity. (eur.nl)
Finally, using an approach that mimicked a ring vaccination protocol in human or animal populations, a CiVax vaccine, when loaded with pathogen-derived material isolated from animals infected with one lethal E.coli strain, was able to cross-protect animals against a different lethal E. coli strain. (technologynetworks.com)

Synthetic tumor-associated glycopeptide antigens. (nih.gov)
In addition, our group developed an hybrid gold nanoparticle that can act as a vaccine delivery system for tumor-associated glycopeptide antigens. (nih.gov)

We are exploring analogues that may inhibit proliferation as treatments for IC/BPS or mimic APF activity with specificity for tumors as anticancer agents. (nih.gov)
The complexity of antigens influences the specificity and strength of the immune response they elicit. (microbiologynote.com)

Carbohydrates are presented on the surface of cells primarily in covalent linkages to proteins (glycoproteins, proteoglycans) or lipids (glycolipids, gangliosides). (nih.gov)
T3's approach harnesses engineered bacteria to trigger the immune system "by delivering selected human proteins directly into cells of the tumor microenvironment," the company explains. (drugdiscoverynews.com)
Carbohydrates covalently linked to a nonsugar moiety (lipids or proteins). (harvard.edu)
Mass photometry: A powerful tool for carbohydrates-proteins conjugation monitoring and glycoconjugates molecular mass determination. (harvard.edu)
Additionally, foreign antigens may include venom from insects or snakes, pollen, chemicals, or specific proteins found in certain foods. (microbiologynote.com)
After the initial reaction, but atopic individuals have a first-degree relative at an increased number of proteins or carbohydrates. (elastizell.com)
Studying cell (sub)proteoma and its variation under different conditions by mass spectrometry, mass imaging and vibrational spectroscopy including protein interactions with other cellular components (RNA, DNA, lipids, carbohydrates, metabolites) and define dynamics and localization of cellular lipids and proteins. (cnr.it)

Making the Enterobacterial Common Antigen Glycan and Measuring Its Substrate Sequestration. (uams.edu)
Polysialic acid and HNK-1 glycan represent carbohydrates enriched in neural cells. (sbpdiscovery.org)
Glycan-based DC-SIGN targeting vaccines to enhance antigen cross-presentation. (dc4u-technologies.nl)
DC-SIGN mediated antigen-targeting using glycan-modified liposomes: Formulation considerations. (dc4u-technologies.nl)
Singh, SK, Streng-Ouwehand I, Litjens M, Kalay H, Saeland E and VAN KOOYK Y. Tumour -associated glycan modifications of antigen enhance MGL2 dependent uptake and MHC class I restricted CD8 T cell responses. (dc4u-technologies.nl)
Glycan modificatio of the tumor antigen gp100 targets DC-SIGN to enhance dendritic cell induced antigen presentation to T cells. (dc4u-technologies.nl)

Alternatively, synthetic methods for the construction of beta-anomeric analogues of the TN and T-antigen glycopeptides were developed, aiming at antigenic structures having a varied stereochemistry of the linkage between the carbohydrate and the peptide moiety. (nih.gov)
An example of one previously identified biomarker is the Tn antigen, a carbohydrate moiety composed of a GalNAc residue linked to serine or threonine. (nih.gov)

Many ovarian TVMs are not expressed in normal tissues or other tumors. (nih.gov)
These cells usually form a tumor that can be malignant, growing into surrounding tissues and invading other distant areas of the body. (escovaccixcell.com)
Encapsulating anticancer drugs in liposomes enables targeted drug delivery to tumor tissues and prevents damage to the normal surrounding tissues. (researchandmarkets.com)
The structure of those cell surface carbohydrates displays a dramatic change during development, and mature cells express cell surface carbohydrates specific to different organs and tissues. (sbpdiscovery.org)
Cell surface carbohydrates thus serve as a zip code for different organs and tissues. (sbpdiscovery.org)
The immune system can distinguish between self-antigens (antigens derived from the body's own tissues) and foreign antigens. (microbiologynote.com)
Subsequent invasion occurs if the tumor breaks down surrounding tissues. (biomedcentral.com)

As such, Tn is implicated in tumour cell organotropic metastasis. (sussex-research.com)
The cascade of events leading to tumor metastasis is marked by the alternate adhesion and release of the tumor cell with a variety of surrounding cell types. (nih.gov)
After discovery of sialyl Lewis X in neutrophils by Dr. Minoru Fukuda, his laboratory demonstrated that sulfated form of sialyl Lewis X is essential for lymphocyte homing and recruitment of natural killer cells in preventing tumor metastasis to the peripheral lymph node. (sbpdiscovery.org)
The worst outcome is metastasis which results when cells break away from the tumor and seed tumors at distant sites [ 8 ]. (biomedcentral.com)

The resulting humoral immunity could enable the selective eradication of Globo H-presenting tumors. (wikipedia.org)
Injection of antigenic peptides has been widely used as a vaccine strategy to boost T cell immunity. (eur.nl)
Multicomponent Gold-Linked Glycoconjugate Vaccine Elicits Antigen-Specific Humoral and Mixed TH1-TH17 Immunity, Correlated with Increased Protection against Burkholderia pseudomallei. (harvard.edu)
This immunological memory contributes to long-term immunity against specific antigens. (microbiologynote.com)

OBI-888's human Phase I/II study for the treatment of metastatic and locally advanced solid tumors is estimated to finish in December 2022. (wikipedia.org)
The ADC is currently undergoing phase II trial in patients with advanced solid tumors, with an estimated completion date in Dec 2023. (wikipedia.org)

Self antigens tell the immune system that normal cells are not a threat and should be ignored ( 2 ). (blogspot.com)
In contrast, microbes are recognized by the immune system as a potential threat that should be destroyed because they carry foreign, or non-self, antigens. (blogspot.com)
Normally, the immune system distinguishes these self-antigens as part of the body's own components and does not initiate an immune response against them. (microbiologynote.com)
However, in individuals with autoimmune disorders, a malfunction occurs, and the body fails to differentiate between self-antigens and foreign antigens. (microbiologynote.com)

16. Simultaneous CD8+ T cell responses to multiple tumor antigen epitopes in a multipeptide melanoma vaccine. (nih.gov)
These epitopes can be unique to each antigen or shared among different antigens. (microbiologynote.com)

The Tn antigen (GalNAc-α-1-O-Thr/Ser) is a well-known tumor-associated carbohydrate determinant. (diamond.ac.uk)

Our goal is to optimize these various nanoconstructs to enhance a glycopeptide-specific immune response that will be specific for distinct tumors bearing these antigens. (nih.gov)
Antigens are substances that have the potential to cause the body to mount an immune response against them. (blogspot.com)
Most vaccines are made with harmless versions of microbes-killed or weakened microbes, or parts of microbes-that do not cause disease but are able to stimulate an immune response against the microbes. (blogspot.com)
An antigen is a substance that elicits an immune response within the body. (microbiologynote.com)
The immune system recognizes these foreign antigens as "non-self" and mounts an immune response against them. (microbiologynote.com)
Antigens are capable of triggering an immune response. (microbiologynote.com)
After an initial exposure to an antigen, memory cells are generated, enabling a more rapid and robust immune response upon subsequent encounters with the same antigen. (microbiologynote.com)
A substance added to killed vaccines to stimulate a better immune response by the body. (mysanantoniovet.com)
The faster and greater immune response produced by an animal who has previously encountered that specific antigen. (mysanantoniovet.com)

4. Targeting a mimotope vaccine to activating Fcgamma receptors empowers dendritic cells to prime specific CD8+ T cell responses in tumor-bearing mice. (nih.gov)
AMAX outperformed synthetic long peptides in terms of both CD8+ and CD4+ T cell responses and allowed functionalization with DC-SIGN-binding carbohydrates for in vivo dendritic cell targeting strategies, boosting T cell responses even further. (eur.nl)
Tacalyx aims to treat tumors by targeting molecules found on the surface of many types of tumor cells called Tumor-Associated Carbohydrate Antigens (TACAs). (labiotech.eu)
Joshi MD, Unger WJ, Storm G, van Kooyk Y, Mastrobattista E. Targeting tumor antigens to dendritic cells using particulate carriers. (dc4u-technologies.nl)

J. Metabolism of carbohydrates, lipids, amino acids nucleotides and vitamins. (whitekoo.com)

5. Induction of protective immune responses against NXS2 neuroblastoma challenge in mice by immunotherapy with GD2 mimotope vaccine and IL-15 and IL-21 gene delivery. (nih.gov)

Here, we generated antigenic peptides into non-linear trimers by solid phase peptide synthesis, thereby enhancing antigen presentation by dendritic cells to CD8+ T cells in vitro and in vivo. (eur.nl)
This platform, termed Antigen MAtriX (AMAX) improved yield, purity and solubility of trimers over conventional solid phase synthesis strategies. (eur.nl)
We have developed a new synthesis of this antigen that is equipped with a chemically-defined specific linker to attach to macromolecules or other surfaces. (nih.gov)
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS). (lookformedical.com)
Click chemistry compared to thiol chemistry for the synthesis of site-selective glycoconjugate vaccines using CRM197 as carrier protein. (harvard.edu)

It is a therapeutic vaccine using a single immunostimulatory peptide called E75, derived from the HER2/neu receptor, and administered in combination with granulocyte-macrophage colony-stimulating factor (GM-CSF) as an adjuvant. (escovaccixcell.com)

9. Peptides mimicking GD2 ganglioside elicit cellular, humoral and tumor-protective immune responses in mice. (nih.gov)

Several preventive vaccines have been developed to prevent HPV and HBV infection, and other related cancers. (escovaccixcell.com)

1. Immunization with a mimotope of GD2 ganglioside induces CD8+ T cells that recognize cell adhesion molecules on tumor cells. (nih.gov)
15. Human tumor-derived heat shock protein 96 mediates in vitro activation and in vivo expansion of melanoma- and colon carcinoma-specific T cells. (nih.gov)
CD8+ T cells from mice vaccinated with trimers showed an KLRG1+ effector phenotype and were able to recognize and kill antigen-expressing tumor cells ex vivo. (eur.nl)
A new tumor model, combining human embryonic stem cells (ESC) and tumor cells, develops abundant human vessels. (nih.gov)
Finally, our preliminary data suggest that the ESC-ovarian tumor model has human tumor vascular cells. (nih.gov)
Tumor vascular cells are critical for the growth of tumor stem cells, which reside within the vascular niche. (nih.gov)
One challenge with characterizing tumor stem cells has been finding appropriate conditions for in vivo growth. (nih.gov)
We hypothesize that the ESC ovarian tumor model, with human vascular cells, will provide an ideal microenvironment to support human stem cell growth. (nih.gov)
If successful, this will create a murine tumor model that nearly completely reproduces the human tumor microenvironment with human tumor stroma, vessels and tumor stem cells. (nih.gov)
In addition, APF inhibits proliferation of bladder carcinoma and many other solid tumor cells at similar concentrations. (nih.gov)
Removal of the tumor does not automatically mean that all cancerous cells are eliminated. (escovaccixcell.com)
Likewise, chemotherapy and radiation therapy are not ideal solutions as they tend to damage the healthy cells along with the tumor cells. (escovaccixcell.com)
Current approaches for the expansion of T-cells may produce T-cells with a terminally differentiated phenotype that is associated with diminished anti-tumor activity and poor capacity for long-term persistence. (nih.gov)
Upon injection under the skin of mice, the ciVAX vaccine forms a permeable scaffold that recruits immature dendritic cells (DCs), educates them to present PAMP-derived antigens, and additionally activates and releases them again. (technologynetworks.com)
Normal cells in the body have antigens that identify them as "self. (blogspot.com)
Antigens can induce the formation of memory cells within the immune system. (microbiologynote.com)
van Vliet SJ, Gringhuis SI, Geijtenbeek TB and VAN KOOYK, Y. Regulation of effector T cells by antigen-presenting cells via interaction of the C-type lectin MGL with CD45. (dc4u-technologies.nl)
Furthermore, lectin-like receptors are one of two complex families of membrane receptors that recognize carbohydrates expressed on all cells. (openpr.com)

It is important to remember that most Covid vaccinations have these graphene/iron oxide "adjuvants" in them, especially childhood vaccines since 2008, flu shots, shingles and pneumonia vaccinations, as well as many medical treatments and procedures. (truth11.com)

Generation of a Fully Human scFv that binds Tumor-Specific Glycoforms. (uams.edu)

Alternative vaccine conjugates have been developed which avoid issues associated with the protein carrier KLH by substituting it with a lipid or carbohydrate-based carrier. (wikipedia.org)
We have coated the TF antigen to gold surfaces and Quantum Dots (QDs) in a variety of different presentations (simple linked TF, TF-amino acid conjugates and larger TF-containing glycopeptides) and showed that some of these construct have very interesting biological functions. (nih.gov)

However, for the most common bacterial pathogens that cause sepsis and many other diseases, still no vaccines are available. (technologynetworks.com)
ciVAX vaccines combine two technologies that are currently in clinical development for other applications, and that together enable the capture of immunogenic antigens from a broad spectrum of pathogens and their incorporation into immune cell-recruiting biomaterial scaffolds. (technologynetworks.com)
Injected or implanted under the skin, ciVAX vaccines then reprogram the immune system to take action against pathogens. (technologynetworks.com)
Broadly protective semi-synthetic glycoconjugate vaccine against pathogens capable of producing poly-ß-(1?6)-N-acetyl-d-glucosamine exopolysaccharide. (harvard.edu)
Foreign antigens originate from the outside of the body and may be pathogens (such as disease-causing viruses or bacteria), allergens (such as pollen), or toxins (such as venom or chemicals). (microbiologynote.com)

Additionally, in vivo studies of OBI-888 in various Globo H-positive (GH+) xenografts models showed promising tumor growth inhibition results. (wikipedia.org)

One of these therapeutic vaccines is called VGX-3100. (escovaccixcell.com)

The use of glycopeptides that incorporate this structure has become a significant and promising niche of research owing to their potential use as anticancer vaccines. (diamond.ac.uk)
Glycopeptides with TN antigen (GalNAc)Ser/Thr and T-antigen structures (beta Gall-3GalNAc)Ser/Thr, described as tumor-associated antigens, were synthesized and coupled to bovine serum albumin. (nih.gov)
As a further type of potential tumor-associated antigen, fucosyl-chitobiose asparagine glycopeptides were synthesized, deprotected, and coupled to bovine serum albumin. (nih.gov)

Bleomycin is a glycopeptide congeners' family of antitumor antibiotics employed for the treatment of several types of tumors such as squamous cell carcinomas and malignant lymphomas. (bvsalud.org)

11. Characterization of GD2 peptide mimotope DNA vaccines effective against spontaneous neuroblastoma metastases. (nih.gov)
The identification and characterization of specific antigens play a pivotal role in diagnosing autoimmune disorders and developing targeted treatment approaches. (microbiologynote.com)

Biodegradable implants of carmustine are already used in the treatment of malignant brain tumors. (researchandmarkets.com)

First, carbohydrate-containing surface molecules (PAMPs) of killed bacteria are captured with magnetic beads coated with FcMBL. (technologynetworks.com)
These antigens appear when a cell transforms into a tumor cell and carbohydrate molecules on the cell surface become abnormal. (labiotech.eu)
Other molecules can be used for immunization as well, for example in experimental vaccines against nicotine (NicVAX) or the hormone ghrelin in experiments to create an obesity vaccine. (iprojectmaster.com)

Sialic-acid Ig-like binding lectins (SIGLECs) are a family of adhesion and signaling receptors that specifically recognize sialylated carbohydrate moieties. (nih.gov)

Since it is well known that monovalent sugar-protein binding is a very weak interaction, inhibitors of these events utilize 'multivalency' (multiple copies of the carbohydrate ligand) to enhance the strength of this effect. (nih.gov)
In nutrition, the process of moving protein, carbohydrates, fats, and other nutrients from the digestive system into the bloodstream. (nih.gov)
A tumor marker is a protein, genetic fragment, or other substance that indicates the presence of a tumor. (healthline.com)
CA 125 is a glycoprotein (a protein with carbohydrate groups) normally found in your blood. (healthline.com)

Rod shaped viruses with a high aspect ratio have superior penetration into tumor tissue [ 11 ] [ 15 ] . (encyclopedia.pub)
These substances are accumulating in blood vessels as they self-organize and self-replicate with the magnetic and electrically conductive materials found in the vaccines that are being used by the pre-programmed graphene oxide to build unidentifiable structures in blood vessels and tissue that block blood flow creating strokes and heart attacks. (truth11.com)

At present, active components such as saponins, flavonoids, fatty acids, polyalkynes, volatile oils and other nutrients such as amino acids, carbohydrates, vitamins and trace elements have been isolated from PQR. (frontiersin.org)

Highlighting the technology's potential, they found that a prophylactic ciVAX vaccine, protected all vaccinated mice against a lethal attack with an antibiotic-resistant E. coli strain, while only 9% of unvaccinated control animals survived. (technologynetworks.com)

Vaccines currently available aim to prevent infection for types 16 and 18. (escovaccixcell.com)
This illustration shows how a ciVax infection vaccine against a pathogenic E. coli strain is produced and applied. (technologynetworks.com)
Now, as reported in Nature Biomedical Engineering, a multi-disciplinary team of researchers at Harvard's Wyss Institute for Biologically Inspired Engineering and John A. Paulson School for Engineering and Applied Sciences (SEAS) developed a biomaterial-based infection vaccine (ciVAX) approach as a solution that could be broadly applied to this pervasive problem. (technologynetworks.com)
With colleagues from Japan, Dr. Fukuda discovered that certain carbohydrates function as antibiotics against Helicobacter pylori infection, which is a leading cause for peptic ulcer and gastric carcinoma. (sbpdiscovery.org)
Vaccines against microorganisms that cause diseases can prepare the body's immune system, thus helping to fight or prevent an infection. (iprojectmaster.com)

Also, tumor-associated antigens and neo-antigens could be incorporated in AMAX for tumor-specific CD8+ T cell responses. (eur.nl)
That region of the immunoglobulin molecule that varies in its amino acid sequence and composition, and comprises the binding site for a specific antigen. (lookformedical.com)
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. (lookformedical.com)
Antigens are recognized by the immune system in a highly specific manner. (microbiologynote.com)

Importantly, immunization with a mix of neoantigen AMAX could reduce tumor growth in a pre-clinical syngeneic mouse model. (eur.nl)

Carbohydrates are the most abundant biomolecules on earth and serve many functions, including structure, nutrition and information transfer 1 . (nature.com)

Processes that encourage the loss of cellular control may be tumor initiators (directly causing mutations) or promoters (facilitating mutations). (biomedcentral.com)

In a pig model of septic shock induced by a different human E. coli isolate, a ciVAX vaccine prevented the development of sepsis in all four animals, while four unvaccinated animals developed severe and sudden sepsis within 12 hours. (technologynetworks.com)

The beads are then combined with mesoporous silica (MPS) rods and immune cell-recruiting GMCSF and immune cell-activating CpG adjuvant to form the complete ciVax vaccine. (technologynetworks.com)
The cell surface is heavily coated with carbohydrates. (sbpdiscovery.org)

Development of anti-vascular immunotherapeutics, with few exceptions, has been hindered by the absence of a tumor model with human tumor vessels. (nih.gov)
Before the development and wide use of human vaccines, few people survived childhood without experiencing a litany of diseases including measles, mumps, rubella, chickenpox, whooping cough, and rotavirus diarrhea. (iprojectmaster.com)

Anatomy12

Organisms16

Diseases27

Chemicals and Drugs134

Analytical, Diagnostic and Therapeutic Techniques and Equipment37

Phenomena and Processes31

Disciplines and Occupations1

Technology, Industry, Agriculture2

Information Science4

Health Care5

Antibodies15

Cancer55

Antibody15

TACA2

Glycans12

Vaccination3

Glycopeptide antigens2

Specificity2

Proteins7

Glycan6

Moiety2

Tissues7

Metastasis4

Immunity4

Solid tumors2

Self antigens4

Epitopes2

Determinant1

Immune response9

Targeting4

Lipids1

Immunotherapy1

Synthesis5

Receptor1

Humoral1

Cancers1

Cells18

Adjuvants1

Binds1

Conjugates2

Pathogens5

Additionally1

Therapeutic vaccines1

Glycopeptides3

Squamous1

Characterization2

Malignant1

Molecules3

Recognize1

Protein4

Tissue2

Amino acids1

Prophylactic1

Infection5

Specific4

Clinical1

Biomolecules1

Mutations1

Isolate1

Cell2

Development2