Utility tolerability patient dropouts. Medical search. Frequent questions

Some studies have advocated combining lamotrigine with valproate in refractory patients, to achieve maximum efficacy through a favourable pharmacodynamic interaction. (pocketdrugguide.com)
Combined buprenorphine/naloxone, however, also demonstrates significant efficacy and favorable safety and tolerability in multiple populations, including youth and prescription opioid-dependent individuals, as does buprenorphine monotherapy in pregnant women. (lww.com)
Most currently available interventions have similar overall efficacy, and treatment choices should reflect the situation of individual patients. (psychiatrist.com)
The Ocular Hypertension Treatment Study (OHTS) is a multicenter, prospective, randomized, controlled clinical trial studying more than 1800 research subjects, evaluating the safety and efficacy of medical treatment in preventing or delaying the onset of visual-field loss and/or optic nerve damage in patients with ocular hypertension who are at moderate risk for developing primary open-angle glaucoma (POAG). (medscape.com)
Although no Food and Drug Administration (FDA) approved treatment has an indication for GD, a number of controlled trials have assessed the efficacy and tolerability of different pharmacotherapies. (springer.com)
To evaluate the safety and efficacy of abatacept plus methotrexate (MTX) over 5 years in patients with rheumatoid arthritis. (jrheum.org)
We describe safety analyses for all patients who received at least 1 dose of abatacept and efficacy analyses for the original ~10 mg/kg abatacept-treated group, over 5 years. (jrheum.org)
Abatacept maintained the efficacy observed at Year 1 over 5 years of treatment, and demonstrated consistent safety and tolerability. (jrheum.org)
This Phase IIb study demonstrated the safety and efficacy of abatacept plus methotrexate (MTX) over 1 year of double-blind (DB) treatment in patients with RA and an inadequate response to MTX 3 , 4 , and confirmed ~10 mg/kg to be the most effective dose. (jrheum.org)
Subsequent Phase III studies verified the efficacy and safety of abatacept both in patients with an inadequate response to MTX 5 and in patients with an inadequate response to anti-TNF agents 6 . (jrheum.org)
We describe the safety, tolerability, and efficacy of abatacept ~10 mg/kg over 5 years of treatment in the continuing open-label longterm extension (LTE) of a Phase IIb study. (jrheum.org)
We report on the safety and tolerability of all patients who received at least 1 dose of abatacept over 5 years, and the efficacy and health-related quality of life (HRQOL) of patients who had received ~10 mg/kg abatacept over 5 years in this continuing open-label extension of a Phase IIb study. (jrheum.org)

Believing that the atypicals were more efficacious, had fewer side-effects and may even be 'neuroprotective', decreasing the long-term deterioration and negative symptoms often associated with schizophrenia, the authors hypothesised 10 years ago that patients randomised to clozapine would have better long-term outcomes than those randomised to chlorpromazine. (cambridge.org)
If milestones in the R61 phase are achieved, up to 3 years of additional support (R33 phase) may be awarded to replicate the impact of the natural product on the biological signature(s) when used by humans and assess whether there is an association between the degree of the impact on the biological signature and functional or clinical outcomes in a patient population. (nih.gov)
Outcomes for patients with melanoma have improved over the past decade with the clinical development and approval of immunotherapies targeting immune checkpoint receptors such as programmed death-1 (PD-1), programmed death ligand 1 (PD-L1) or cytotoxic T lymphocyte antigen-4 (CTLA-4). (biomedcentral.com)

The current state of pharmacology research for CUD highlights the need to consider particular characteristics of patients, such as gender, impulsivity, and severity of cannabis use, when selecting a medication in the off-label treatment of CUD or cannabis withdrawal. (nature.com)
Information about medication usage and tolerability are also collected. (biomedcentral.com)
However, doctors during this time only had few choices of medication for patients. (drugwatcher.org)
Later on, it became clear that these symptoms do not indicate the effectiveness of a drug and these effects also lead to patients' non-compliance with medication. (drugwatcher.org)
However, there was a trend for a greater rate of dropout due to adverse effects of study medication in patients who received escitalopram. (medilib.ir)

4 This 2-year study of 332 postmenopausal North American women with low bone mass investigated denosumab or placebo in patients with lumbar spine bone mineral density (BMD) -1.0 to -2.5 who did not meet the criteria for osteoporosis and were without previous fracture. (healthplexus.net)
Patients were randomized to denosumab injections (60 mg every 6 months) plus oral placebo weekly or oral alendronate weekly (70 mg) plus subcutaneous placebo injections every 6 months. (healthplexus.net)
Reference Elkes and Elkes 5 Chlorpromazine was given to 27 chronically overactive patients with psychosis (three described as 'senile') and alternated with placebo for varying periods to ascertain the drug's impact on behaviour over 22 weeks. (cambridge.org)
PRECISE is a prospectively registered, double blind, randomised placebo controlled trial of pregabalin compared to placebo, in addition to usual care in patients with sciatica. (biomedcentral.com)
Patients were randomized to abatacept 10 or 2 mg/kg or placebo, plus MTX. (jrheum.org)
A 16-week randomized trail compared escitalopram (10 or 20 mg per day) with placebo in 125 patients who were about to commence treatment for newly diagnosed or recurrent stage II to IV epidermoid cancer of the head and neck, and were not receiving treatment for depression or anxiety, and did not meet criteria for major depression [ 9 ]. (medilib.ir)

The purpose of this chapter is to describe some of the common meanings of pain in patients with DPNP, as currently reported in the literature, how these meanings interact with other common factors in pain experience, including specific negative emotions or moods (depression, anxiety, anger), or the psychosocial context surrounding pain, and to describe available evidence on the effectiveness of cognitive behavioral therapy (CBT) for patients with DPNP. (researchgate.net)
Clinical Implications: Pain in patients with DPNP involves a range of threatening pain sensations, including sensations with burning, shooting, tingling, or cramping qualities, and additional more cognitive meanings linked to persistent pain, including a sense that pain disrupts daily life in an intrusive way. (researchgate.net)
Similarly, I have often argued for the cognitive effects of ECT to be categorized as a 'tolerability' rather than a 'safety' issue, since the standard definition of medical safety involves physical injury or death. (blogspot.com)

The study evaluated the effects of transitioning to denosumab on changes in BMD and biochemical markers of bone turnover, and on safety and tolerability compared with continuation of alendronate therapy. (healthplexus.net)
Serological and biochemical responses of patients were assessed. (wjgnet.com)

RESPITE investigated the safety, feasibility and benefit of switching from PDE5i to riociguat in these patients. (ersjournals.com)

In refractory patients, doses may be as high as 500-1000 mg/day. (pocketdrugguide.com)
Under this FOA, trials must be designed so that results, whether positive or negative, will provide information of high scientific utility and will support decisions about further development or testing of the natural product. (nih.gov)
Furthermore, the clinical antipsychotic trials of intervention effectiveness (CATIE) also found that in spite of patients' high tolerability to atypical antipsychotics, at present, there is a high dropout rate in the use of these drugs due to either inefficacy or intolerable side effects. (drugwatcher.org)
Patients often report high disability levels and negative mood. (unboundmedicine.com)
INTRODUCTION - Patients with cancer have a high rate of psychiatric comorbidity, approximately one-half exhibit emotional difficulties. (medilib.ir)
High exposure to VPA can lead to carnitine depletion causing a misbalance between the intra-mitochondrial beta-oxidation and the microsomal co-oxidation, a pathway that produces toxic metabolites such as 4-en-VPA which inhibits ammonia elimination. (unav.edu)

Compared to sedated patients, nonsedated status showed an increased first-order absorption rate constant (1.1 vs. 0.1 h(-1)) and a 24% reduction in bioavailability (F-NS) at 14 days post-transplant. (unav.edu)
The dropout rate was low. (ox.ac.uk)

Thus, the pain literature includes limited information about the common meanings of living with diabetic peripheral neuropathic pain (DPNP) from the perspective of patients. (researchgate.net)
Introduction: Diabetic peripheral neuropathy (DPN) affects almost 30% to 50% of patients with diabetes, 40% to 60% of whom suffer from diabetic peripheral neuropathic pain (DPNP). (researchgate.net)

Given the heavy personal burden that DPNP imposes on patients and the considerable challenge of managing the condition pharmacologically, clinical use of non-pharmacological therapies such as CBT for painful diabetic neuropathy might be warranted in individual patients. (researchgate.net)
All patients who completed the 1-year, DB period of this study (clinical trial registration number: NCT00254293) 3 , 4 were eligible to enter the open-label LTE period. (jrheum.org)
Six patients (10%) experienced clinical worsening, including death in two (not study drug-related). (ersjournals.com)
We searched http://www.clinicaltrials.gov (web site of the US National Institutes of Health) and the World Health Organization Clinical Trials Registry Platform (ICTRP) ( http://www.who.int/ictrp/en/ ) for ongoing trials (last search 28 August,2013), and the reference lists of reviewed articles. (unboundmedicine.com)
See "Patients with cancer: Overview of the clinical features and diagnosis of psychiatric disorders" . (medilib.ir)
Methods Demographic, clinical and pharmacological variables, including tacrolimus whole blood concentrations obtained from therapeutic drug monitoring and data from dense-sampling pharmacokinetic profiles, were recorded in 26 paediatric patients with biliary atresia who underwent liver transplantation between 2016 and 2021. (unav.edu)

Typical doses for patients with newly diagnosed epilepsy are 100-200 mg/day. (pocketdrugguide.com)

6 She described this study as having particular utility given the common scenario of patients on a regime of alendronate who seek to switch treatment. (healthplexus.net)
The evidence strongly supports the use of agonist therapies to reduce opioid use and to retain patients in treatment, with methadone maintenance remaining the gold standard of care. (lww.com)
Palmitoylethanolamide (PEA), a naturally occurring fatty acid amide, has demonstrated utility in the treatment of neuropathic and inflammatory pain. (mdpi.com)
For GD patients not willing to consider drug treatment, n-acetyl cysteine or behavioral therapies may be effective. (springer.com)
A proportion of pulmonary arterial hypertension (PAH) patients do not reach treatment goals with phosphodiesterase-5 inhibitors (PDE5i). (ersjournals.com)
32 patients (52%) experienced study drug-related adverse events and 10 (16%) experienced serious adverse events (2 (3%) study drug-related, none during the PDE5i treatment-free period). (ersjournals.com)
When clozapine was discovered, it became evident that this drug can apparently improve delusions and hallucinations in treatment-resistant patients. (drugwatcher.org)
DEPRESSION - The sections below discuss management and treatment of depression in patients with cancer. (medilib.ir)
The number of new combinations treatment under development for melanoma provides options for the number of patients to achieve a therapeutic benefit. (biomedcentral.com)
However, PD-1 and CTLA-4 blocking agents are not effective in all patients, and even those patients who do respond initially can relapse, highlighting the need for improved treatment regimens. (biomedcentral.com)
These results support the synergistic effect of dual checkpoint inhibition over monotherapy and identify relatlimab-nivolumab as a potential new treatment option for patients with previously untreated metastatic or unresectable melanoma. (biomedcentral.com)
To bypass resistance, combination treatment with immunotherapies and single or multiple TKIs have been shown to improve the prognosis of melanoma patients compared to monotherapy. (biomedcentral.com)
NERLYNX was approved by the U.S. FDA in July 2017 for the treatment of patients with early stage HER2-positive breast cancer who have previously been treated with a trastuzumab containing regimen. (seekingalpha.com)
In general, the first choice for treatment is the least invasive one, with the least number of potential complications for the patient. (medscape.com)
Absorbent products may also be used temporarily until a definitive treatment has a chance to work, in patients awaiting surgery, or long-term if treatment has yielded less-than-perfect results. (medscape.com)

Consequently, it is critical for clinicians to understand the impact of lifestyle choices on the ocular surface so that they can communicate with their patients to optimise their health and, wherever possible, institute preventative steps to mitigate potential health risk factors. (uwaterloo.ca)

Originally prescribed to treat schizophrenia and the manic symptoms of bipolar disorder, the drug was found to have obvious risks of male breast growth and an increased risk of death among elderly patients with dementia. (drugwatcher.org)
Out on PubMed, from investigators in China, is this LTE: Inflammatory mediators and the effect of electroconvulsive therapy in patients with schizophrenia. (blogspot.com)
Short and well presented, with very interesting data about white cell decrease after ECT in patients with schizophrenia. (blogspot.com)

Method: A retrospective descriptive analysis of 464 patients who received inpatient ECT from May 2017 to March 2021 in a large tertiary psychiatric institution was conducted. (blogspot.com)

Risk is increased for children under 16, and is also more common with concomitant valproate use, and in patients who have experienced rash on other anti-epileptic drugs. (pocketdrugguide.com)

Dropout rates were similar in both arms, and the incidence and type of adverse and serious adverse events were balanced. (healthplexus.net)
Incidence rates of adverse events (AE) and serious AE were 489.7 and 20.0/100 patient-years in Year 1 versus 374.9 and 18.9/100 patient-years in the cumulative period, respectively. (jrheum.org)
The dropout rates due to any reason did not differ between CBTs and controls. (unboundmedicine.com)

In contrast, lithium or other mood stabilizers may be most effective for GD for patients presenting with a co-occurring bipolar spectrum disorder (BSD). (springer.com)
Out on PubMed, from authors in Singapore, is this study: Effect of early electroconvulsive therapy on length of stay in patients with bipolar, depressive and psychotic disorders. (blogspot.com)
This study aimed to evaluate the association between early ECT and LOS in three main groups of patients with bipolar, depressive and primary psychotic disorders. (blogspot.com)

A recent very large, randomized open-label study indicated that lamotrigine might be the drug of choice in patients with partial epilepsy, as it was equally effective but better tolerated, but in a companion study it was substantially less effective than valproate in patients with generalized or unclassified epilepsy. (pocketdrugguide.com)
The purpose of this qualitative study was to elucidate the effects of DPNP on daily life and individual feelings regarding living with DPNP from the perspective of Turkish patients. (researchgate.net)
Conclusion: This study revealed that the majority of patients carry significant concerns about becoming a burden on their family and are afraid of becoming dependent on others because of DPNP. (researchgate.net)

Reducing levodopa or dopamine agonist (DA) dosages may partially reduce GD symptoms among patients with co-occurring PD. (springer.com)
The latest Global Initiative for Asthma guidelines recommend their use in all patients who experience asthma symptoms or self-administer a short-acting β-agonist (SABA) twice or more per month, in those who awaken because of asthma once or more per month, or in those with less frequent symptoms with one or more risk factors for an exacerbation ( 2 ). (atsjournals.org)

Further quantitative, qualitative or mixed methods research is needed to more fully understand common experiences of pain in patients with DPNP, and the common meanings ascribed to these experiences. (researchgate.net)

These include patient and provider concerns regarding co-morbidities, adherence, and side effect management. (biomedcentral.com)

Three-times-a-day dosing may improve tolerability. (pocketdrugguide.com)

As a result, these patients had to suffer from movement disorders, which is a common side effect in typical antipsychotics. (drugwatcher.org)

ADJUSTMENT DISORDER - The identification and diagnosis of adjustment disorder is not straightforward but is important since many of these patients will benefit from counseling. (medilib.ir)
Indeed, the recent British Thoracic Society/Scottish Intercollegiate Guidelines Network guidelines recommend ICS therapy in all patients once the diagnosis of asthma is confirmed ( 3 ). (atsjournals.org)

In conclusion, selected patients with PAH may benefit from switching from PDE5i to riociguat, but this strategy needs to be further studied. (ersjournals.com)
Conclusion A population pharmacokinetic model of sublingually administered tacrolimus in paediatric patients was developed to characterize different absorption mechanisms. (unav.edu)

The number of serious adverse events and adverse events will be reported, and the proportion of patients per group who have at least one event will be compared using Fisher's exact test. (biomedcentral.com)

The patients most at risk for depression and other psychiatric illness have advanced disease, a prior psychiatric history, poorly controlled pain, and other life stressors or losses. (medilib.ir)

The inhibition of two immune checkpoints, LAG-3 using relatlimab and PD-1, improved progression-free survival (PFS) to a greater extent than inhibition of PD-1 alone in patients with previously untreated metastatic or unresectable melanoma. (biomedcentral.com)

Unfortunately, many patients still progress and acquire resistance to immunotherapy and molecularly targeted therapies. (biomedcentral.com)
PD-1 and CTLA-4 targeting therapies increase average life expectancy for cancer patients. (biomedcentral.com)

The incidence of depression (scores on the Quick Inventory of Depressive Symptomatology-Self Rated ≥11) was less in patients treated with active drug (10 versus 25 percent). (medilib.ir)

In addition to these psychiatric conditions, nonspecific distress and anxiety are very common in cancer patients. (medilib.ir)

The story of the atypical antipsychotics is a tale of the triumph of profit over patient benefit, of marketing over ethics. (cambridge.org)
Physicians attempting to identify individuals who could benefit from counseling should focus upon a lack of patient flexibility [ 1,2 ]. (medilib.ir)

The model was able to explain the oral absorption pattern in nonsedated patients as the result of gut bioavailability (0.9) and hepatic extraction ratio, with the latter being responsible for first-pass effects. (unav.edu)

Denosumab, which reduces bone turnover markers, is delivered via subcutaneous injection every 6 months, an advantage in an older patient population. (healthplexus.net)
Therefore, we aimed to develop a population pharmacokinetic model of sublingually administered tacrolimus in patients who cannot swallow the capsules due to their age, sedation status and/or mechanical ventilation during the first weeks post-transplantation. (unav.edu)

It has been found to be particularly effective in patients with Lennox-Gastaut syndrome. (pocketdrugguide.com)

Others believe that if the incontinence is severe and correctable by surgical means, a trial of medical therapy is not mandatory and does not need to be performed if the informed patient chooses to proceed directly to surgery. (medscape.com)

Yet, felbamate may still be an important drug in the armamentarium for refractory patients, because it may control seizures when other drugs fail, and tends to be alerting rather than sedating. (pocketdrugguide.com)

Memorial Sloan Kettering was founded in 1884, and today is a world leader in patient care, research, and educational programs. (mskcc.org)

More than 50% of the members of the National Association for Continence (NAFC), a national support group for incontinent patients, use some form of protective garment to remain dry. (medscape.com)

One-hundred HCV patients were enrolled in an open-label, multicenter trial. (wjgnet.com)

Few studies have focused on individual experiences of DPNP in patients with diabetes. (researchgate.net)

CBTs are effective in enhancing patients' beliefs in their own abilities and developing ways to deal with health problems. (unboundmedicine.com)

The checksum field above contains a CRC-16 %%% checksum as the first value, followed by the %%% equivalent of the standard UNIX wc (word %%% count) utility output of lines, words, and %%% characters. (utah.edu)

Patients completing the 1-year, double-blind period entered the longterm extension, where all patients received a fixed dose of abatacept ~10 mg/kg. (jrheum.org)

If the patient is receiving valproate at the time of initiation, starting doses and doses during titration should be cut in half, whereas if they are receiving enzyme-inducing anti-epileptic drugs such as phenytoin, carbamazepine or phenobarbital, doses can be doubled. (pocketdrugguide.com)

Method: A total of 14 patients were interviewed, and interpretative phenomenological analysis was used to identify themes. (researchgate.net)

1073 patients in CBT groups and 958 patients in control groups. (unboundmedicine.com)

Psychiatry and Psychology1

Anthropology, Education, Sociology and Social Phenomena1

Named Groups2

Efficacy12

Outcomes3

Medication5

Placebo6

Cognitive3

Biochemical2

Safety1

High6

Rate2

Neuropathic Pain2

Clinical6

Newly diagnosed1

Treatment15

Ocular1

Schizophrenia3

20171

Concomitant1

Rates3

Bipolar3

Study3

Agonist2

Methods1

Include1

Improve1

Suffer1

Diagnosis2

Conclusion2

Proportion1

Risk1

Greater1

Therapies2

Versus1

Common1

Benefit2

Effects1

Population2

Effective in patients1

Therapy1

Drug1

Care1

Support1

Open-label1

Studies1

Health1

Standard1

Year1

Drugs1

Total1

Groups1