• He allegedly told deputies that he had previously performed castrations on animals and had removed one of his own testicles in 2012. (oxygen.com)
  • In castration, the testicles are removed in order to address problems relating to prostate enlargement. (liu.se)
  • Castration is any action, surgical, chemical, or otherwise, by which a male loses use of the testicles: the male gonad. (wikipedia.org)
  • Surgical castration is bilateral orchiectomy (excision of both testicles), while chemical castration uses pharmaceutical drugs to deactivate the testes. (wikipedia.org)
  • The term castration may also be sometimes used to refer to emasculation where both the testicles and the penis are removed together. (wikipedia.org)
  • Either surgical removal of both testicles or chemical castration may be carried out in the case of prostate cancer. (wikipedia.org)
  • Testosterone-depletion treatment (either surgical removal of both testicles or chemical castration) is used to slow down the cancer, greatly reduce sex drive or interest in those with sexual drives, obsessions, or behaviors, or any combination of those that may be considered deviant. (wikipedia.org)
  • A vet removes both testicles which takes away the main source of the male hormone, testosterone. (bluecross.org.uk)
  • If your male dog is being castrated, a vet will make a small incision so that their testicles can be removed. (bluecross.org.uk)
  • The testes (testicles) are two almond-shaped male sex organs contained in a sac called the scrotum, which sits directly behind the penis. (testocreams.com)
  • Most men discover cancer in their testicles through self-examination, but doctors also find many early cases as part of a routine physical examination. (testocreams.com)
  • In addition, castration removes both testicles, which removes the risk of any health issues directly associated with them such as testicular tumours. (knutsfordvetsurgery.co.uk)
  • The practice is linked to a subculture where men become 'nullos' - short for genital nullification - by having their penis and testicles removed. (com.ng)
  • For improving meat quality especially tenderness, male cattle are usually castrated to removes both the testicles. (animbiosci.org)
  • Castration is a process that removes or inactivates the testicles of a bull by using either surgical or stopping blood flow to the testes and immunocastration methods [ 8 ]. (animbiosci.org)
  • However, in the months after the botched surgery, the man said he began to suffer from suicidal thoughts and 'regrets' ever having his testicles removed. (americanuckradio.com)
  • An individual assigned male at birth whose testicles have been surgically removed or rendered nonfunctional and who identifies as a eunuch. (msdmanuals.com)
  • Giving olaparib and radium Ra 223 dichloride may work better at treating castration-resistant prostate cancer. (endourology.ph)
  • Patient and Methods: Retrospective analysis of trials using androgen receptor axis-targeted drugs for metastatic castration resistant prostate cancer patients (mCRPC). (lu.se)
  • Olaparib, a poly (ADP-ribose) polymerase inhibitor, has demonstrated an improvement in median progression-free survival (PFS) in select patients with metastatic castration-resistant prostate cancer (mCRPC). (bmj.com)
  • The study will enroll participants with metastatic castration-resistant prostate cancer (mCRPC) previously treated with one prior androgen receptor axis-targeted therapy (ARAT). (uclahealth.org)
  • Alicia Morgans, MD, MPH presents the case of a 70-year-old man with progressive PSMA-positive mCRPC. (targetedonc.com)
  • In the U.S., prostate cancer is the second most common cancer in men, and despite an increase in the number of available therapies for patients with mCRPC, five-year survival remains low. (yahoo.com)
  • These data continue to provide evidence of anti-tumor activity and clinical benefit in patients with metastatic castration-resistant prostate cancer (mCRPC). (arvinas.com)
  • Background: The optimal number of 3-wk docetaxel plus prednisone (DP) cycles for metastatic castration-resistant prostate cancer (mCRPC) is unclear. (eur.nl)
  • 10 cycles of DP in men with mCRPC in this retrospective hypothesis-generating analysis. (eur.nl)
  • Prostate-specific membrane antigen (PSMA) is an excellent target for radionuclide therapy of metastasized castration-resistant prostate cancer (mCRPC). (snmjournals.org)
  • Despite recent approval of some novel drugs, metastatic castration-resistant prostate cancer (mCRPC) remains a lethal disease and additional treatment options are still needed. (snmjournals.org)
  • TALAPRO-1: A Phase 2, Open-Label, Response Rate Study of Talazoparib in Men With DNA Repair Defects and Metastatic Castration-Resistant Prostate Cancer Who Previously Received Taxane-Based Chemotherapy and Progressed on at Least 1 Novel Hormonal Agent (Enzalutamide and/or Abiraterone Acetate/Prednisone. (pfizer.com)
  • Apalutamide for metastatic, castration-sensitive prostate cancer. (springer.com)
  • Efficacy and safety of abiraterone acetate in elderly (75 years or older) chemotherapy naïve patients with metastatic castration resistant prostate cancer. (springer.com)
  • Potential drug-drug interactions with abiraterone in metastatic castration-resistant prostate cancer patients: a prevalence study in France. (springer.com)
  • Received 1 prior ARAT for metastatic or non-metastatic, castration-sensitive or castration-resistant prostate cancer. (uclahealth.org)
  • The story of this patient is common for men who develop metastatic castration-resistant prostate cancer. (targetedonc.com)
  • Phase II study of abiraterone acetate in chemotherapy-naive metastatic castration-resistant prostate cancer displaying bone flare discordant with serologic response. (jamanetwork.com)
  • This clinical trial is studying a potential treatment for men with metastatic castration resistant prostate cancer. (facingourrisk.org)
  • Biomarker-Directed Therapy in Black and White Men With Metastatic Castration-Resistant Prostate Cancer. (cdc.gov)
  • A Florida man was arrested after allegedly performing a botched castration on a man he'd met on a dark web fetish website for eunuchs. (oxygen.com)
  • Testicular torsion (twisting testes from bell clapper deformity) occurs in 4.5 cases per 100,000 American males per year aged 1 to 25, so it is more prevalent than testicular cancer. (testocreams.com)
  • Testicular cancer occurs in 4.2 males out of every 100,000. (testocreams.com)
  • Testicular cancer is the most common cancer affecting men aged 15 to 35. (testocreams.com)
  • Castration eliminates the risk of testicular cancer. (wikidoc.org)
  • Aim 1: To assess preferences and barriers for de-implementation of chemical castration in prostate cancer. (biomedcentral.com)
  • Although some patients with prostate cancer benefit from ADT in terms of survival and symptom improvement, chemical castration is also commonly performed when there is no high level evidence for use and little to no health benefits to patients raising questions of low value care. (biomedcentral.com)
  • Chemical castration is achieved by administering hormones. (testocreams.com)
  • At a research conference, Hayes remarked that he chose the term "chemical castration" specifically because it angered Syngenta representatives. (niche-canada.org)
  • BIRMINGHAM, Ala. (WBRC) - There's a bill on Governor Kay Ivey's desk that would require convicted sex offenders on parole to undergo chemical castration. (wsfa.com)
  • The bill says a person convicted of a sex offense involving a child under 13, who is eligible for parole, will be required to undergo chemical castration. (wsfa.com)
  • A person required to undergo the chemical castration must begin the treatment no less than one month prior to their release from custody, and must continue treatment until the court determine it's no longer necessary. (wsfa.com)
  • The statement adds Clark will "submit to chemical castration upon release. (truecrimedaily.com)
  • Chemical castration occurs when an offender is given a drug called medroxyprogesterone acetate. (truecrimedaily.com)
  • Chemical Castration==== Chemical castration is a form of temporary castration caused by hormonal medication. (wikidoc.org)
  • In the case of chemical castration, ongoing regular injections of [[anti-androgen]]s are administered. (wikidoc.org)
  • Chemical castration seems to have a greater effect on bone density than physical castration. (wikidoc.org)
  • In study B, 23 patients with castration-resistant prostate cancer received probes for CYP3A4 (midazolam), CYP2C9 (warfarin), CYP2C19 (omeprazole), and CYP2C8 (pioglitazone), and transporter substrates for P-glycoprotein (P-gp) (fexofenadine) and breast cancer resistance protein (BCRP)/organic anion transporting polypeptide (OATP) 1B1 (rosuvastatin) at baseline and after repeat once-daily administration of apalutamide 240 mg to steady state. (springer.com)
  • An open-label, multicenter, phase Ib study investigating the effect of apalutamide on ventricular repolarization in men with castration-resistant prostate cancer. (springer.com)
  • This phase I/II trial studies the best dose and side effects of olaparib and how well it works with radium Ra 223 dichloride in treating patients with castration-resistant prostate cancer that has spread to the bone and other places in the body. (endourology.ph)
  • Trial design and objectives for castration-resistant prostate cancer: updated recommendations from the Prostate Cancer Clinical Trials Working Group 3. (jamanetwork.com)
  • Today's topic is a new antiandrogen for the treatment of men with nonmetastatic, castration-resistant prostate cancer . (medscape.com)
  • During a hearing at the Old Bailey, Gustavson, 45, from Haringey, north London , pleaded not guilty to causing grievous bodily harm with intent to three men on dates in 2018 and 2019. (com.ng)
  • The surgery performed on the 55-year-old man took place in August 2019. (bolde.com)
  • Gary Jon Vanryswyk, 76, performed the botched procedure on the 55-year-old male back in August 2019 after they connected on eunuch.com. (americanuckradio.com)
  • There is a widespread belief that many men undergo surgery unnecessarily, with the risk of various negative side-effects. (lu.se)
  • Castration of normal male mice induces expansion of the bone marrow B cell population, an effect that can be reversed by androgen replacement. (jci.org)
  • One has to wonder what would have happened if the men had been screened with a PET scan, either in addition to or instead of using the CT scan and the bone scan. (medscape.com)
  • Men with prostate cancer are often castrated with long-acting injectable drugs termed androgen deprivation therapy (ADT). (biomedcentral.com)
  • One in three men with prostate cancer is chemically castrated at some point with long-acting injectable drugs (i.e., androgen deprivation therapy or ADT) [ 2 ]. (biomedcentral.com)
  • Adding enzalutamide (Xtandi) to androgen deprivation therapy (ADT) can extend metastasis-free survival while maintaining quality of life in men with prostate cancer who have a high risk for biochemical recurrence, according to new research presented at the European Society of Medical Oncology (ESMO) meeting in Madrid. (medscape.com)
  • Enzalutamide, an oral androgen receptor inhibitor, has already shown benefits in patients with metastases , and the current EMBARK trial explored whether the inhibitor can help men with earlier-stage disease who are at risk for metastases. (medscape.com)
  • The androgen receptor is a protein that has an important role in the male reproductive system. (lu.se)
  • Castration reduces potassium-stimulated norepinephrine release from superfused olfactory bulbs of male rats. (omeka.net)
  • In order to investigate the possible relationship among the olfactory bulb (OB), norepinephrine (NE) and gonadal steroids, we measured NE release from superfused anterior and posterior OB in intact and castrated male rats (Expt. (omeka.net)
  • METHODS: Male Sprague-Dawley rats were submitted to renovascular hypertension by the two kidney-one clip (2K1C) model and treated with doxycycline (30 mg/kg/day) by gavage from the third to seventh-day post-surgery. (bvsalud.org)
  • In her thesis, Elin Björk investigates the treatment method that was prevalent from the late 19th century to the early 20th century: castration. (liu.se)
  • Researchers say the childhood castration and subsequent opera career of 19th-century singer Gaspare Pacchierotti left permanent marks on his skeleton. (mentalfloss.com)
  • Castration is most commonly performed to treat cancer or reduce the almost certain risk of cancer. (testocreams.com)
  • I called my vet to ask him why there is such a negative response to sterilization and why almost every male dog I've encountered isn't neutered. (theamericanmag.com)
  • Guided by the theoretical domains framework (TDF), urologists and patients from facilities with the highest and lowest castration rates across the VA will be interviewed to identify key preferences and de-implementation barriers for reducing castration as prostate cancer treatment. (biomedcentral.com)
  • The investigators will conduct national surveys of urologists to prioritize key barriers identified in Aim 1 for stopping incident castration as localized prostate cancer treatment using a DCE experiment design. (biomedcentral.com)
  • Aim 3: To pilot two tailored de-implementation strategies to reduce castration as localized prostate cancer treatment. (biomedcentral.com)
  • By monitoring early-response biomarkers in men undergoing 177Lu-PSMA prostate cancer treatment, physicians can personalize dosing intervals, significantly improving patient outcomes. (news-medical.net)
  • Overall, the male castration surgery provides students with hands-on skills and an understanding of the work done by scientific researchers and health care professionals. (ed.gov)
  • Neutering is when a vet prevents a male or female dog from reproducing through surgery. (bluecross.org.uk)
  • Here at Knutsford Veterinary Surgery we usually advise delaying castration in these large breeds until skeletally mature which can be anywhere from 10 - 18 months old. (knutsfordvetsurgery.co.uk)
  • Your team at Knutsford Vets can offer castration and neutering services in our state of the art surgery. (knutsfordvetsurgery.co.uk)
  • If some of the men being treated did indeed have metastatic disease, we have to consider whether they would benefit best from apalutamide or enzalutamide, or if giving them chemotherapy would be a better approach. (medscape.com)
  • If undesirable behaviours are noted then castration at the onset of these behaviours may be beneficial except in the case of fear or anxiety related behaviours. (knutsfordvetsurgery.co.uk)
  • Medical consequences === A subject of castration who is castrated before the onset of [[puberty]] will retain a high voice, non-muscular build, and small genitals. (wikidoc.org)
  • Castrations after the onset of puberty will typically reduce the sex drive considerably or eliminate it altogether. (wikidoc.org)
  • s (2010) highly cited scientific paper found that "Atrazine-exposed males" were "chemically castrated," meaning that they could not reproduce as biological males or had such other "sexual abnormalities. (niche-canada.org)
  • Castration reduces aggressive behaviour by male sheep, injuries when handling male sheep and unplanned breeding, allowing for improved health and welfare. (www.csiro.au)
  • Real-world evidence suggests that about half of men with metastatic hormone-sensitive disease receive ADT alone in that frontline setting. (targetedonc.com)
  • Castration in humans has been proposed, and sometimes used, as a method of birth control in certain poorer regions. (wikidoc.org)
  • Because, you can bet that even the books featuring male heroes depict a feminized universe-a universe where female badasses, or at any rate, females in traditionally male roles, are cast as supporting or secondary characters, and the male heroes totally respect these ladies' competency in investigative techniques, hand-to-hand combat, and firearms usage, and you had better do the same if you're not some ignorant, knuckle-dragging throwback. (menoforder.com)
  • 2 Ten percent of the population became "atrazine-induced females" that were "completely feminized" as adults: they reproduced as biological females, "mated with control males, and produced viable eggs. (niche-canada.org)
  • As the article explains, the photograph depicts one of the "sex reversed genetic males" who become "reproductively functional females. (niche-canada.org)
  • 2010) photo, captioned: "The so-called pregnant man has company: One of the most common weed-killers in the United States can transform male frogs into fully functional females, a new study says. (niche-canada.org)
  • 9 The article continues that Hayes's male frogs "not only became submissive, like females, but also apparently send out come-hither signals to the bro's in their tank. (niche-canada.org)
  • In common usage the term is usually applied to males, although as a medical term it is applied to both males and females. (wikidoc.org)
  • Dog castration can also help improve your dog's overall behaviour as it can help root out aggressive and protective behaviours that tend to be more common in male entire dogs. (knutsfordvetsurgery.co.uk)
  • The most common reason is that the male dog's penis swells inside the female's vagina during intercourse. (everycreaturecounts.org)
  • While the swelling is happening, the male dog's penis is locked inside the female's vagina. (everycreaturecounts.org)
  • If the female dog's vagina is not relaxed, it will contract around the male dog's penis, making it difficult for him to withdraw. (everycreaturecounts.org)
  • In Australia, 1 in 650 males is born with Klinefelter syndrome. (testocreams.com)
  • My thesis shows that when it comes to the castration of men, the female body has been the norm. (liu.se)
  • Thus, knowledge of how the female body functioned was transferred to the male body, and by extension, knowledge of women's bodies was used as an argument for the castration of men. (liu.se)
  • The point of departure in the treatment of men was the female body. (liu.se)
  • The equivalent of castration for female animals is spaying. (wikipedia.org)
  • Everybody knew, without having to think long about it, that the most impressive female character was logically going to be smaller, weaker, and less likely to take direct action than the males against whom she would have to compete. (menoforder.com)
  • Neutering is a vital part of population control and without castrating your male dog, hormone driven behavioural problems can arise if your pet comes into contact with an unneutered female. (knutsfordvetsurgery.co.uk)
  • sex refers especially to the physical and biologic traits that are physically evident at birth and is often captured in the phrases "assigned male at birth" (AMAB) and "assigned female at birth" (AFAB). (msdmanuals.com)
  • An internal sense of being male, female, or something else, which may or may not correspond to an individual's sex assigned at birth or sex characteristics. (msdmanuals.com)
  • Describes an individual whose gender identity does not align with a binary understanding of gender, including those who think of themselves as both male and female, neither, moving between genders, a third gender, or outside of gender altogether. (msdmanuals.com)
  • The classification of gender into 2 discrete categories of male and female (a paradigm of the past that did not allow for those who do not identify as male or female). (msdmanuals.com)
  • Design, setting, and participants: An exploratory analysis compared outcomes of 332 men who received DP in the TAX-327 trial, which stipulated up to 10 cycles, and 220 men who received DP in CS-205, a randomized phase 2 trial comparing DP plus AT-101 (bcl-2 inhibitor) versus DP plus placebo, which allowed up to 17 cycles. (eur.nl)
  • Men in both arms of CS-205 were combined for analysis, as no significant differences in outcomes were observed. (eur.nl)
  • He has also previously performed another similarly botched procedure on a man in a motel room who later went to a hospital for proper treatment, but charges were never filed charges and the situation was not reported, authorities said. (oxygen.com)
  • For men with prostate problems, castration was a treatment method for many years. (liu.se)
  • But by studying castration as a treatment for benign prostate enlargement, Elin Björk discovered that the prevalent notion in medicine of the man as norm is not always accurate. (liu.se)
  • Castration as a treatment method for prostate hypertrophy 1893-1910. (liu.se)
  • Although castration can help ease dominant and aggressive behaviours, it is important to remember that a dog can 'learn' that they are acceptable behaviours and actions. (knutsfordvetsurgery.co.uk)
  • Study A randomized 45 healthy men to single-dose apalutamide 240 mg alone or with strong inhibitors of cytochrome P450 (CYP)3A4 (itraconazole) or CYP2C8 (gemfibrozil). (springer.com)
  • Data from other trials suggest there may be improved activity in men with DNA damage repair (DDR) mutations treated with checkpoint inhibitors. (bmj.com)
  • Two more men previously admitted removing other body parts belonging to Gustavson, who filmed the procedures and uploaded them to his 'eunuch-maker' site, which subscribers would pay to watch. (com.ng)
  • A 76-year-old man will spend three years in prison after pleading no contest to the unlicensed practice of a health care profession resulting in serious bodily injury after he performed a botched castration on a man he met on a eunuch website. (bolde.com)
  • A Florida pensioner is expected to spend two years behind bars after he was charged for castrating a man he met on a eunuch fetish website. (americanuckradio.com)
  • What do Iron Man 2 and Terry Gilliam's The Fisher King have in common? (overthinkingit.com)
  • In 2002, biologist Dr. Tyrone Hayes conducted a series of experiments that revealed that the most common herbicide, Atrazine, "feminized" male frogs at concentrations below that allowed in drinking water in the United States. (niche-canada.org)
  • Pre- or post-pubertal castration of male cattle is a common management practice in beef production systems. (animbiosci.org)
  • The common gender question used to annoy me but now I realize her "old man" beard is confusing, so I don't take it personally. (theamericanmag.com)
  • Prostate cancer is one of the most common forms of cancer, affecting around 10 000 Swedish men every year. (lu.se)
  • Police found the injured man on a bed, holding a towel to his bloody groin, according to WFTS of Tampa Bay, Florida. (oxygen.com)
  • The Leviticus Holiness code, for example, specifically excludes eunuchs or any males with defective genitals from the priesthood, just as castrated animals are excluded from sacrifice. (wikipedia.org)
  • The charges relate to the alleged clamping and splitting of the genitals of the men, who cannot be identified for legal reasons. (com.ng)
  • The recommendation of castration timing is performed on a case by case basis as there are different factors to consider. (knutsfordvetsurgery.co.uk)
  • A population-based case-control study of 427 male lung cancer patients residing in a mining area of Southern China and 1,011 controls was carried out to address this and other issues. (who.int)
  • But in the early 20th century, decisions regarding castration were based on the belief that the prostate was the equivalent of the uterus in the woman. (liu.se)
  • Van Ryswyk told deputies he'd met the victim on a "a website for those that have a fetish for castration," according to an arrest report cited by Buzzfeed News . (oxygen.com)
  • Half-castration emerged as an alternative practice to be used for increasing the yield and tenderness of male cattle meat. (animbiosci.org)
  • In terms of meat quality, the HC resulted in two times greater fat content in both muscles examined compared to intact males. (animbiosci.org)
  • 2010) appeals to cultural disgust for male bodies that transgress gender norms and to cultural anxieties about transgender people "passing" as cisgender. (niche-canada.org)
  • Also: male gaze on the Gender Ads Project . (metafilter.com)
  • People who were assigned male at birth (AMAB) and have adopted a gender identity as a woman, regardless of whether they have undergone any medical gender transition. (msdmanuals.com)
  • One example is that drugs are developed based on the male body. (liu.se)
  • Gary Van Ryswyk has been charged with practicing medicine without a license resulting in bodily injury after deputies showed up to his home and allegedly found a man holding a bloody towel to his groin and a "pink container which held two body parts. (oxygen.com)
  • In medicine, the male body has long been the norm. (liu.se)
  • They found that the star's early castration and later musical success had indeed left traces on his body. (mentalfloss.com)
  • A man has admitted freezing the leg of an alleged ringleader of an extreme body-modifications group, who is accused of filming castrations and posting videos of them online. (com.ng)
  • Some endocrine facts, such as the sequelae coined the term "hormone" for this internal of castration, are deeply rooted in the past. (who.int)
  • But at the same time it was also realized that the American males had to be adequately mind-kontrolled to be made willing to sacrifice themselves for the COL RKM Banksters, without understanding specifically how or why they were being conned. (veteranstoday.com)
  • But while castration-for-entertainment's-sake seems barbaric today, it was quite commonplace at the time, and its victims were celebrated. (mentalfloss.com)
  • Our research is helping the sheep sector manage the health and welfare of lambs at tail docking and castration time, known as 'marking', as well as other livestock management practices. (www.csiro.au)
  • James Pennington conducted the home castration on a transgender woman in Denver, Colorado. (ibtimes.co.uk)
  • James Pennington, 57, who is a commercial airline pilot based at Chicago O'Hare where he flew for United Express, performed the home castration, which took around 90 minutes, at the transgender woman's flat. (ibtimes.co.uk)
  • 10 These "transgender animals" became "male mothers" who allowed males to fertilize their eggs, which grew into offspring. (niche-canada.org)