• Owens, CL & Epstein, JI 2007, ' Significance of denuded urothelium in papillary urothelial lesions ', American Journal of Surgical Pathology , vol. 31, no. 2, pp. 298-303. (johnshopkins.edu)
  • Urothelium is susceptible to carcinoma. (wikipedia.org)
  • The primary aim of this work was to survey normal urothelium and transitional cell carcinoma (TCC) for the presence of T lymphocytes expressing the intraepithelial, CD103(+) phenotype. (ox.ac.uk)
  • Purpose To investigate the effects of thermochemotherapy with mitomycin C (MMC) on normal rabbit bladder urothelium and to compare it with standard intravesical MMC and hyperthermia with normal saline. (sdu.edu.tr)
  • This study assessed the actions of PGE 2 , PGF 2 , PGD 2 , TXA 2 , and PGI 2 on urinary bladder urothelium with lamina propria (U&LP), and detrusor smooth muscle. (biomedcentral.com)
  • Prostaglandins are synthesised in both the bladder urothelium with lamina propria (U&LP) and in detrusor smooth muscle in response to stretch, nerve stimulation, U&LP damage or other inflammatory mediators [ 10 , 11 ]. (biomedcentral.com)
  • Difficulties in routine diagnostics of urothelium lesions]. (bvsalud.org)
  • Normal urothelium expressed mRNA for all four uroplakins, although UPIII could be detected only by ribonuclease protection assay. (york.ac.uk)
  • Further analysis revealed that these changes were accounted for by a fourfold increase in Cx43 mRNA of SMC but not urothelial cell and by a fivefold increase in Cx26 mRNA of urothelium. (unige.ch)
  • TRPV4 mRNA was detected in urinary bladder smooth muscle (UBSM) and urothelium of TRPV4 +/+ mouse bladders. (aspetjournals.org)
  • Specifically, of interest is to determine how the actions of the prostaglandins affect urothelium with lamina propria that is separated from the detrusor smooth muscle. (biomedcentral.com)
  • Occasional T lymphocytes (CD3(+)) were seen in normal urothelium and lamina propria. (ox.ac.uk)
  • The involvement of prostaglandins in bladder physiology was first recognised from their release after urinary bladder distension or injury to the urothelium [ 1 , 2 ]. (biomedcentral.com)
  • Here we investigated the role of muscarinic receptors in mediating cell proliferation in the human UROtsa cell line, which is a widely used experimental model to study urothelium physiology and pathophysiology. (unibs.it)
  • The inner surface of the urinary tract is lined with epithelial tissue, or urothelium, which functions as a barrier to bacteria, environmental carcinogens, toxins, and the numerous and variable waste products in urine. (nih.gov)
  • Microbiota in Urine and Urothelium Can be a Factor for Induction of Urinary Bladder Cancer. (who.int)
  • In response to stretch urothelium releases various substances that modulate afferent nerve activity. (maastrichtuniversity.nl)
  • Differential expression of functional cannabinoid receptors in human bladder detrusor and urothelium. (desertharvest.com)
  • Consequently, we investigated the expression of functional cannabinoid 1 and 2 receptors in the human bladder detrusor and urothelium. (desertharvest.com)
  • Erratum to 'Muscarinic receptors stimulate cell proliferation in the human urothelium-derived cell line UROtsa' [Pharmacol. (unibs.it)
  • Transitional epithelium lines the organs of the urinary system and is known here as urothelium (PL: urothelia). (wikipedia.org)
  • Distribution of lymphocytes of the alpha(E)beta(7) phenotype and E-cadherin in normal human urothelium and bladder carcinomas. (ox.ac.uk)
  • If the human bladder works similarly, then loss of normal urothelium mechanosensory signals due to disease or injury may lead to some forms of urinary frequency, urinary urgency, and urinary incontinence in people, and treatments based on this knowledge may follow. (nih.gov)
  • Western blotting and immunohistochemistry demonstrated protein expression in both the UBSM and urothelium that was absent in TRPV4 −/− bladders. (aspetjournals.org)
  • TRPV4 activation with GSK1016790A contracted TRPV4 +/+ mouse bladders in vitro, both in the presence and absence of the urothelium, an effect that was undetected in TRPV4 −/− bladders. (aspetjournals.org)
  • Examination of some of these workers indicated the presence of a damaged urothelium consistent with premalignant conditions. (cdc.gov)
  • T lymphocytes of the CD103(+) phenotype are present in normal urothelium where they may play a role in immunosurveillance. (ox.ac.uk)
  • It increases the permeability barrier and strength of the urothelium. (sigmaaldrich.com)
  • In contrast, strong prostaglandin receptor type 2 staining was seen in the urothelium and in suburothelial cells. (maastrichtuniversity.nl)
  • Loss of β1‑integrin from urothelium results in overactive bladder and incontinence in mice: a mechanosensory rather than structural phenotype. (nih.gov)
  • Upk3b is dispensable for development and integrity of urothelium and mesothelium. (mpg.de)
  • Thus, prostaglandin produced by urothelium may target prostaglandin receptor types 1 and 2 in the urothelium and suburothelium. (maastrichtuniversity.nl)
  • Therefore, our research activities are based on understanding the basic organization and differentiation of the epithelium of the urinary bladder (urothelium) in benign and malignant conditions. (ukaachen.de)
  • Transitional epithelium lines the organs of the urinary system and is known here as urothelium (PL: urothelia). (wikipedia.org)
  • Purpose: The repertoire of mucin (MUC) gene expression in the normal human urothelium is poorly defined and the alterations in MUC gene expression following transposition of intestinal segments into the urinary tract has not previously been studied. (ncl.ac.uk)
  • It is speculated that these urinary proteins and their inhibitors play a crucial role in regulating desquamation of urothelium, which constitutes a vital defence mechanism against bacterial attachment. (biomedcentral.com)
  • Histologically confirmed, unresectable, locally advanced or metastatic transitional cell carcinoma of the urothelium (UC) (including the renal pelvis, ureter, urinary bladder, or urethra). (nih.gov)
  • We hypothesize that one or more of these gene products derived from renal urothelium will serve as biomarkers that correlate with the severity of urinary tract obstruction in these children. (sciencedaily.com)
  • At the level of the lumbosacral spinal cord, lower urinary tract reflex mechanisms are modulated by supraspinal controls with mechanosensory input from the urothelium, resulting in regulation of bladder contractile activity. (duke.edu)
  • The sensory, transduction, and signalling properties of the urothelium can influence adjacent urinary bladder tissues including the suburothelial nerve plexus, interstitial cells of Cajal, and detrusor smooth muscle cells. (duke.edu)
  • Changes to the urothelium are associated with a number of bladder pathologies that underlie urinary bladder dysfunction. (duke.edu)
  • loss of the umbrella cell layer (superficial urothelium) was evident while intermediate and basal urothelial cells were preserved. (medscape.com)
  • 6 ]. As normal urothelium is characterised by cytoplasmic cytokeratin 20 expression in terminally differentiated superficial cells, cytokeratin 20 was taken as a marker of complete terminal differentiation of urothelial cells in bladder biopsies. (biomedcentral.com)
  • 10. Autologous transplantation of urothelium into demucosalized gastrointestinal segments: evidence for epithelialization and differentiation of in vitro expanded and transplanted urothelial cells. (nih.gov)
  • Stage III (T1/T2/T3, N0/N1, M0): Tumor invades urethral subepithelial connective tissue right under the urothelium (T1), OR tumor invades the prostatic stroma surrounding ducts either by direct extension from the urothelial surface or by invasion from prostatic ducts (T2), OR tumor invades the periprostatic fat (T3). (oncolink.org)
  • Diverse stimuli, including those that activate TRP channels expressed by the urothelium, can influence urothelial release of chemical mediators (such as ATP). (duke.edu)
  • primary_diagnosis A C191672 C177537 GDC Value Terminology C191672 Papillary Urothelial Neoplasm of Low Malignant Potential A papillary neoplasm of the urothelium. (nih.gov)
  • In contrast, cultured human stratified urothelium, which does not undergo complete terminal differentiation of its superficial cells, does not express cytokeratin 20. (biomedcentral.com)
  • their synthesis requires differentiation of the vesical urothelium. (biomedcentral.com)
  • 2 ] In contrast to normal urothelium, cultured human stratified urothelium does not undergo complete terminal differentiation of its superficial cells. (biomedcentral.com)
  • It is possible that injury to the spinal cord, and consequent lack of trophic effect upon the urothelium, may lead to incomplete maturation and differentiation. (biomedcentral.com)
  • 8. Transplantation of autologous differentiated urothelium in an experimental model of composite cystoplasty. (nih.gov)
  • Urothelium is characterised by terminally differentiated superficial cells ("umbrella cells"), that express uroplakins in their luminal plasma membrane and cytokeratin 20 in their cytoplasm. (biomedcentral.com)
  • Papillary tumors stand out against a background of smooth urothelium. (webpathology.com)
  • other: no hyperplastic changes in the urothelium or carcinomas were found when treated with sodium nitrate alone. (europa.eu)
  • citation needed] The urothelium is the most impermeable membrane in the mammalian body. (wikipedia.org)
  • Thus the mammalian urothelium, besides acting as a permeability barrier, may serve important functions in prevention of bacterial cystitis. (biomedcentral.com)
  • Normal urothelium is characterised by terminally differentiated superficial cells, which express cytokeratin 20 in the cytoplasm. (biomedcentral.com)
  • The basal expression patterns of the metallothionein (MT) and heat shock proteins 27, 60, and 70 were determined in these cells, and expression was in agreement with that known to occur for in situ urothelium. (nih.gov)
  • Figure Legend: Figure 1 Kidney, Urothelium - Hyperplasia in a male F344/N rat from a chronic study. (nih.gov)
  • Although Dr. Becknell and his research team expected changes in the expression of certain genes depending on the type and amount of kidney damage present, they were surprised to learn that the changes were primarily restricted to a single cell layer, in this case, the renal urothelium. (sciencedaily.com)
  • 9. Prerequisite for successful surgical outcome in urothelium lined seromuscular colocystoplasty. (nih.gov)
  • All of them provided cancer tissue samples and 50 of them provided non-cancerous urothelium samples. (medsci.org)
  • Stage I (T1, N0, M0): Tumor invades urethral subepithelial connective tissue right under the urothelium (T1). (oncolink.org)
  • Both MUC1 and MUC4 were up-regulated in transposed ileal segments, genes expressed by the normal human urothelium. (ncl.ac.uk)
  • Nonmalignant urothelium had uniform expression of LN5 genes and lacked methylation. (nih.gov)
  • Altogether the abovementioned findings were suggestive of a diffuse disruption of the urothelium. (medscape.com)
  • The findings suggest that the UROtsa cells grown with a serum-free medium could be a valuable adjunct for studying environmental insult to the human urothelium in general and for the stress response in particular. (nih.gov)
  • In patients with clam enterocystoplasty there was evidence of increasing up-regulation of MUC2, 3, 4 and 5AC expression in the urothelium toward the anastomotic site. (ncl.ac.uk)
  • The overall morphology was most consistent with that found in the intermediate layers of in situ urothelium. (nih.gov)
  • The UROtsa cell line was isolated from a primary culture of normal human urothelium through immortalization with a construct containing the SV40 large T antigen. (nih.gov)
  • Of the remaining 53 cases, in which the umbrella cell layer of the urothelium was intact, immunostaining for cytokeratin 20 was seen only in ten biopsies. (biomedcentral.com)
  • The working hypothesis in the present study was that this cell line could be induced to differentiate and express known features of in situ urothelium if the original serum-containing growth medium was changed to a serum-free formulation. (nih.gov)
  • 18. Seromuscular colocystoplasty lined with urothelium: experimental study. (nih.gov)
  • In two patients with bladder malignancy, there was histologic evidence of outward pagetoid extension of this process along urothelium and onto the genital mucosa. (nih.gov)
  • Figure 1) may be observed as a chemically induced lesion or as a regenerative lesion associated with inflammation (Figure 2) or secondary to an injury to the urothelium. (nih.gov)
  • Examination of some of these workers indicated the presence of a damaged urothelium consistent with premalignant conditions. (cdc.gov)