AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
ParaquatUrineHerbicidesManebPoisoningUrinalysisSuperoxide DismutaseOxidative StressCarbarylCatalaseSelenium OxidesKidney Failure, ChronicAcute Kidney InjuryEncyclopedias as TopicKidneyRenal DialysisPolycystic Kidney DiseasesKidney Diseases
Tested the effects of paraquatToxicityGlyphosateSerumHerbicideToxicolIngestionDiquatSeverityIntoxicationAbsorptionPulmonaryDichlorideAcuteLungDecreasesModerate to severePrognosisTissuesPrognosticClinicalKidneysDetectionEnergy-dependentExposureChronicMicePesticidesWidelyMortalityBloodDiagnosisLaboratoryConventionalTreatmentStableSamplesCasesTestPatientsReviewFactorsTimeFoodPresence
Tested the effects of paraquat1
  • To address this issue, we tested the effects of paraquat in a genetic reference population of mice (the BXD recombinant inbred strain family). (cdc.gov)
Toxicity7
  • According to world health organization (WHO), paraquat is categorized as moderately hazardous, but its ingestion is associated with high toxicity and mortality and there is no specific antidote for paraquat poisoning. (ac.ir)
  • Eligible patients presented with acute paraquat toxicity between 1 January 2016 and 31 December 2020. (biomedcentral.com)
  • Paraquat poisoning can manifest as acute and chronic toxicity. (biomedcentral.com)
  • Overall, our results suggest that gene Prkag2 and related networks may serve as potential targets against paraquat toxicity and demonstrate the utility of genetically diverse mouse models for the study of complex human toxicity. (cdc.gov)
  • Furthermore, Suc-ker-SOD exhibited much lower immunogenicity and much better therapeutic effects than native and poly(styrene-co-maleic acid)-conjugated SOD against paraquat toxicity in mice. (elsevierpure.com)
  • The slow phase represents the storage pool of paraquat in the lungs and is probably responsible for its pulmonary toxicity. (veteriankey.com)
  • Proposed biochemical mechanism of paraquat toxicity. (veteriankey.com)
Glyphosate2
  • The most frequently implicated agents in these poisonings were insecticides, followed by herbicides such as glyphosate and paraquat [ 4 ]. (biomedcentral.com)
  • The proposed law would prohibit various chemicals that have long been banned in most of the world, but also includes widely used pesticides glyphosate, 2-4,D, paraquat and endosulfan. (publicintegrity.org)
Serum5
  • A case in which paraquat is detected in urine, plasma, or serum. (cdc.gov)
  • Diagnosis of acute failure is often based on a combination of factors such as decreased urine production or increased serum creatinine. (wikipedia.org)
  • At the end of the treatment period, we analyzed the ventral midbrain for concentrations of iron, copper, and zinc, also we measured the concentration of paraquat in cerebellum, and proinflammatory cytokines in serum and cerebellum. (cdc.gov)
  • 7 days were enrolled, a medical history was obtained, and serum and urine specimens were collected. (cdc.gov)
  • RESULTS: Urine anti-DENV IgM sensitivity and specificity were 47.4% and 98.5%, respectively, when compared with serum anti-DENV IgM ELISA results, and 29.7% and 91.1% when compared with serum rRT-PCR results. (cdc.gov)
Herbicide3
  • Canadian limits for use of the herbicide paraquat on fruit are 20 times higher than Australian limits, for example. (alive.com)
  • Paraquat (PQ) is an herbicide used in many countries, including the USA. (cdc.gov)
  • The herbicide paraquat, the dry cleaning solvent carbon tetrachloride, and a group of industrial chemicals known as polychlorinated biphenyls are all examples of substances that can affect the liver. (cura4u.com)
Toxicol1
  • Mitsopoulos P, Suntres ZE, (2011), "Protective Effects of Liposomal N-Acetylcysteine against Paraquat-Induced Cytotoxicity and Gene Expression," J Toxicol. (livonlabs.com)
Ingestion5
  • Ingestion of paraquat typically results in gastrointestinal (GI) signs and symptoms including oropharyngeal ulcerations, vomiting, diarrhea and GI bleeding. (cdc.gov)
  • Medical management of paraquat ingestion. (cdc.gov)
  • A 75-year-old female was admitted to the emergency room with an alleged history of ingestion of 1 glass of paraquat (liquid form). (ac.ir)
  • Self-poisoning through paraquat ingestion is a major cause of morbidity and mortality in the Asia-Pacific region [ 3 ]. (biomedcentral.com)
  • Paraquat can be rapidly absorbed through inhalation, ingestion, and damaged skin. (biomedcentral.com)
Diquat1
Severity3
Intoxication1
  • Many people diagnosed with paraquat intoxication experience AKI, sometimes requiring hemodialysis. (wikipedia.org)
Absorption4
  • The extinction coefficients of the reduced and the oxidized paraquat at these absorption maxima are xi mM 400 = 46.0 and xi mM 258 = 53.6, respectively (Autor, 1977). (inchem.org)
  • EVALUATION FOR ACCEPTABLE INTAKE BIOLOGICAL DATA Biochemical aspects Absorption, distribution and excretion The absorption, distribution, and excretion of paraquat in experimental animals have been reviewed by WHO (1984). (inchem.org)
  • Since there is no known antidote for it, further absorption must be prevented in order to manage paraquat poisoning successfully. (ac.ir)
  • 11. Meredith T, Vale J. Treatment of paraquat poisoning in man: methods to prevent absorption. (ac.ir)
Pulmonary3
  • Multivariate analysis revealed that the amount of paraquat ingested and clinical presentations, particularly pulmonary and cardiovascular system disorders, were significantly associated with mortality. (biomedcentral.com)
  • Our study highlights that the amount of paraquat ingested, along with the presence of pulmonary and cardiovascular system disorders, can serve as prognostic indicators for mortality rates in cases of paraquat poisoning. (biomedcentral.com)
  • Modified from Lewis CPL, Nemery B: Pathophysiology and biochemical mechanisms of the pulmonary toxicant of paraquat. (veteriankey.com)
Dichloride5
  • In 1970 the Meeting estimated an ADI of 0.001 mg/kg b.w. (as paraquat dichloride). (inchem.org)
  • The 1982 Joint Meeting noted that the higher ADI established by the 1972 Meeting (0.002 mg/kg b.w. as paraquat dichloride) was based on long-term studies conducted by Industrial Bio-Test Laboratories (IBT), for which no replacement studies, validations, or additional data had been submitted. (inchem.org)
  • Considering the evidence available, the 1982 Meeting recommended that a reduced ADI (0.001 mg/kg b.w. as paraquat dichloride) be retained on a temporary basis, pending receipt of further data. (inchem.org)
  • FORMULATIONS These include aqueous concentrates (100 - 240 g/l) and water-soluble granules (24 g/kg) of paraquat dichloride. (inchem.org)
  • Following oral single-dose administration of 4 - 6 mg/kg b.w. 14 C-paraquat dichloride to rats, 99 - 102% of the administered dose was found in the faeces (93 - 96%) and in the urine (6%) within 3 days. (inchem.org)
Acute1
Lung2
  • 4. Eddleston M, Wilks M, Buckley N.Prospects for treatment of paraquat-induced lung fibrosis with immunosuppressive drugs and the need for better prediction of outcome: a systematic review. (ac.ir)
  • note the specific coping activity with reliance on memory, applying cognitive forcing strategies, and decreases stimulation of the tissues, and the lung where paraquat is eliminated by the outward repolarizing potassium currents. (revivemedicalny.com)
Decreases1
  • As renal failure develops, the renal clearance of paraquat decreases and the plasma half-life increases from less than 12 hours to 120 hours or longer. (veteriankey.com)
Moderate to severe1
  • Pulse therapy with cyclophosphamide and methylprednisolone in patients with moderate to severe paraquat poisoning: a preliminary report. (ac.ir)
Prognosis2
Tissues2
  • Accurate biomonitoring is an important tool to evaluate human or animal exposure to such herbicides by measuring the levels of these chemicals, their metabolites, or altered biologic structures or functions in biologic materials such as urine, blood or blood components, exhaled air, hair or nails, and tissues. (savco.net)
  • This conclusion is based on the faulty presupposition that the appearance of Vitamin C in the urine indicates all bodily tissues are saturated and the body requires no additional Vitamin C. This assumption is clearly refuted by Hickey, et al. (livonlabs.com)
Prognostic1
  • 13. Scherrmann J. Prognostic value of plasma and urine paraquat concentration. (ac.ir)
Clinical2
  • Paraquat poisoning: clinical features and immediate general management. (cdc.gov)
  • We evaluated the utility of anti-DENV IgM in urine to identify dengue cases among AFI patients enrolled in a clinical study. (cdc.gov)
Kidneys3
  • After i.v. administration of 51 Cr- labeled proteins into mice, native SOD was excreted rapidly into urine and no significant accumulation was observed in organs other than the kidneys. (elsevierpure.com)
  • The liver changes the chemical nature of most toxins , rendering them harmless, while the kidneys filter toxins out of the blood into urine. (illuminatelabs.org)
  • This direct bilirubin diluted in the blood is filtered through the kidneys and eliminated in the urine. (tabletsmanual.com)
Detection1
Energy-dependent1
  • In some cases, speech may be an underlying disorder such as stress, may result from time- and energy-dependent uptake of paraquat poisoning by organ system of cytochrome a3 oxidase with even a relative contraindication usually dictates that the decision to take in excess of the breasts. (oaksofwellington.com)
Exposure1
  • A clinically compatible case in which a high index of suspicion (credible threat or patient history regarding location and time) exists for paraquat exposure, or an epidemiologic link exists between this case and a laboratory-confirmed case. (cdc.gov)
Chronic1
  • Idiopathic central nervous system stimulant acne, boils, indigestion, abortifacient improve health, lengthen life span, chronic bladder disease, paraquat poisoning result from local injury to the brain, and elsewhere with resultant airwaypromise is a specific sexual difficulty or demonstrated an inability to practice values that include nausea, vomiting, and ushing can occur at 28-minute intervals. (reflectionsbodysolutions.com)
Mice4
  • Systems genetics and systems biology analysis of paraquat neurotoxicity in BXD recombinant inbred mice. (cdc.gov)
  • In our earlier work, we showed that in genetically susceptible mice, paraquat increases iron in the ventral midbrain, the area containing the substantia nigra. (cdc.gov)
  • To test this hypothesis, we treated male mice from 28-39 BXD strains plus the parental strains with one of 3 doses of paraquat, 1, 5 and 10 mg/kg three times on a weekly basis. (cdc.gov)
  • The effect on paraquat treated mice with 5 mg/kg and principal component analysis of iron showed suggestive QTL on chromosome 5. (cdc.gov)
Pesticides1
  • Two recent studies found numerous pesticides in the blood and urine of Canadians across the country. (alive.com)
Widely1
  • Paraquat, one of the most widely used herbicides, poses a significant risk of mortality through self-poisoning and subsequent multiple organ failure. (biomedcentral.com)
Mortality1
Blood2
  • Bladder and kidney cancers could result in blood in the urine, while colon cancer could lead to blood in the stool. (natlawreview.com)
  • Blood and urine samples were collected during both studies and vascular tone was measured using laser Doppler imaging. (cambridge.org)
Diagnosis1
  • Early diagnosis, aggressive decontamination and supportive care should be established in paraquat poisoning. (ac.ir)
Laboratory2
  • 5. Hong SY, Yang DH, Hwang KY.Associations between laboratory parameters and outcome of paraquat poisoning. (ac.ir)
  • Urine was tested for anti-DENV IgM, and its sensitivity and specificity to detect sera laboratory-positive dengue cases were calculated. (cdc.gov)
Conventional1
  • Pretreatment with this liposomal NAC was found to be more effective than conventional drugs in reducing the effects of paraquat poisoning. (livonlabs.com)
Treatment2
Stable1
  • OTHER PROPERTIES Solutions of paraquat become intensely purple on reduction, due to the formation of a water soluble, relatively stable free radical, which absorbs at 400 nm. (inchem.org)
Samples1
  • Researchers with the National University of Ireland conducted a biomonitoring survey of 50 Irish adults in June 2017, collecting 20 ml spot urine samples. (aboutlawsuits.com)
Cases1
Test1
Patients1
  • The primary objective aimed to identify the factors associated with death in patients poisoned by paraquat. (biomedcentral.com)
Review1
  • 8. Jha VK, Kannapur AS, Hiremath R. Fatal paraquat poisoning: A case report and review of literature. (ac.ir)
Factors1
  • Rmendations of the client the factors that are not immediately released when your child been dry in the urine to be strongest with factors that. (oaksofwellington.com)
Time1
  • Patient's condition improved over period of time, she started accepting orally and urine output was adequate. (ac.ir)
Food2
  • Their urine and saliva were tested over the course of a year, including during two five-day periods when they switched to diets of organic food. (sott.net)
  • Furthermore, when the children switched to organic food, the levels of organophosphates in their urine and saliva quickly dropped to undetectable or nearly undetectable levels. (sott.net)
Presence1