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DoxorubicinEffects of cyclophosphamideChemotherapyOral cyclophosphamideTake cyclophosphamideHematuriaBladderMetabolitesExcretionDoseMicroscopicDexamethasoneNauseaToxicityInfectionProtein in the urineMedicationsKidneysLupus nephritisPass more urinePlasma and urineAntibioticDosesPatientsHemorrhagicBlood3900MesnaDoctor'sCorticosteroidsBloodyLiverAlbuminCancerNephroticTreatmentPrecautionsOrallyColourBaselineUTIsExposureBiologicalInterfereDrugsBreakdownTablet
Doxorubicin15
  • She completed first-line treatment with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone and achieved complete remission. (cdc.gov)
  • Design and Methods Oral cyclophosphamide, thalidomide, and dexamethasone was compared with infusional cyclophosphamide, vincristine, doxorubicin, and dexamethasone in patients with newly diagnosed multiple myeloma. (haematologica.org)
  • Cyclophosphamide-thalidomide-dexamethasone was non-inferior to cyclophosphamide-vincristine-doxorubicin-dexamethasone for progression-free and overall survival, and there was a trend toward a late survival benefit with cyclophosphamide-thalidomide-dexamethasone in responders. (haematologica.org)
  • A trend toward an overall survival advantage for cyclophosphamide-thalidomide-dexamethasone over cyclophosphamide-vincristine-doxorubicin-dexamethasone was also observed in a subgroup of patients with favorable interphase fluorescence in situ hybridization. (haematologica.org)
  • Compared with cyclophosphamide-vincristine-doxorubicin-dexamethasone, cyclophosphamide-thalidomide-dexamethasone was associated with more constipation and somnolence, but a lower incidence of cytopenias. (haematologica.org)
  • Conclusions The cyclophosphamide-thalidomide-dexamethasone regimen showed improved response rates and was not inferior in terms of survival outcomes to the standard infusional regimen of cyclophosphamide-vincristine-doxorubicin-dexamethasone. (haematologica.org)
  • 14 , 15 It has previously been shown that the addition of cyclophosphamide to VAMP (vincristine, doxorubicin, and methylprednisone), a regimen very similar to VAD, increases response rates. (haematologica.org)
  • 2 , 16 Having developed an oral induction regimen comprising cyclophosphamide, thalidomide, and dexamethasone (CTD), 17 , 18 we compared its efficacy and safety to that of cyclophosphamide plus VAD (CVAD) in a large randomized trial setting whereby, apart from the difference in the mode of administration, thalidomide was in effect an alternative to vincristine plus doxorubicin. (haematologica.org)
  • RATIONALE: Drugs used in chemotherapy, such as paclitaxel albumin-stabilized nanoparticle formulation, doxorubicin, and cyclophosphamide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. (clinicaltrialsgps.com)
  • PURPOSE: This randomized phase II trial is studying paclitaxel albumin-stabilized nanoparticle formulation, doxorubicin, cyclophosphamide, and pegfilgrastim to compare how well they work when given with or without bevacizumab in treating women with inflammatory or locally advanced breast cancer. (clinicaltrialsgps.com)
  • To compare the pathologic complete response rates in women with HER2/neu-negative inflammatory or locally advanced breast cancer treated with paclitaxel albumin-stabilized nanoparticle formulation, doxorubicin hydrochloride, cyclophosphamide, and pegfilgrastim with vs without bevacizumab. (clinicaltrialsgps.com)
  • To evaluate biomarkers with respect to the sequence of paclitaxel albumin-stabilized nanoparticle formulation and doxorubicin hydrochloride/cyclophosphamide/pegfilgrastim administration in patients not receiving bevacizumab. (clinicaltrialsgps.com)
  • Patients then receive doxorubicin hydrochloride IV and cyclophosphamide IV on day 1 and pegfilgrastim SC on day 2 of weeks 14, 16, 18, 20, 22, and 24. (clinicaltrialsgps.com)
  • Arm III: Patients receive doxorubicin hydrochloride IV and cyclophosphamide IV on day 1 and pegfilgrastim SC on day 2 of weeks 1, 3, 5, 7, 9, and 11. (clinicaltrialsgps.com)
  • Bence-Jones -type proteins, doxorubicin, cyclophosphamide, CXD101 vincristine, and prednisolone, A paraprotein The uncommon clinical span of the disease provides prompted us to exclude the reactive character of plasma cell infiltration. (irpa2006europe.com)
Effects of cyclophosphamide3
  • Diuretics of the thiazide class may increase the bone marrow suppression side effects of cyclophosphamide. (marvistavet.com)
  • Allopurinol , a medication used to reduce uric acid crystal deposits, can also increase the bone marrow suppression side effects of cyclophosphamide. (marvistavet.com)
  • As many of these patients are young men and women of child-bearing age, the effects of cyclophosphamide on fertility, along with bone marrow and other adverse effects make alternative medications more attractive. (ukidney.com)
Chemotherapy4
  • Mesna is used therapeutically to reduce the incidence of haemorrhagic cystitis and haematuria when a patient receives ifosfamide or cyclophosphamide for cancer chemotherapy. (wikipedia.org)
  • In chemotherapy, cyclophosphamide is classified as an "alkylating agent" which means it works by binding to DNA, and interfering with normal cell function. (marvistavet.com)
  • Cytoxan generically known as Cyclophosphamide is a chemotherapy drug used to treat a variety of cancers. (onlinepharmaciescanada.com)
  • Methods: We examined the feasibility of alternate high-performance liquid chromatographic-tandem mass spectrometry methods to simultaneously detect eighteen chemotherapy analytes in plasma and urine. (cdc.gov)
Oral cyclophosphamide3
  • The IV mesna infusions would be given with IV ifosfamide, while oral mesna would be given with oral cyclophosphamide. (wikipedia.org)
  • Single agent: oral cyclophosphamide is usually administered at dosages in the range of 1 to 5 mg/kg/day for both initial and maintenance dosing. (wikidoc.org)
  • The recommended dose for oral cyclophosphamide tablets is 2 mg per kg of body weight per day for 8 to 12 weeks. (onlinepharmaciescanada.com)
Take cyclophosphamide6
  • Take cyclophosphamide at around the same time every day. (medlineplus.gov)
  • Take cyclophosphamide exactly as directed. (medlineplus.gov)
  • Usually it is best to take cyclophosphamide first thing in the morning, to reduce the risk of bladder problems. (canadianpharm.org)
  • Follow your doctor's instructions carefully about when to take cyclophosphamide. (canadianpharm.org)
  • Can you take cyclophosphamide at night? (onlinepharmaciescanada.com)
  • Teach patients to take cyclophosphamide early in the day to prevent accumulation of drug in the bladder during the night. (studylib.net)
Hematuria11
Bladder10
  • Two standard methods of preventing cyclophosphamide-related bladder toxicity are hyperhydration and mesna administration. (medscape.com)
  • Deep to this transitional epithelium, which is covered superficially by "umbrella" cells, the bladder submucosa with its microvasculature overlies the detrusor muscle, which is smooth muscle oriented in multiple directions to allow for uniform stretching and the storage of urine. (medscape.com)
  • Mesna, sold under the brand name Mesnex among others, is a medication used in those taking cyclophosphamide or ifosfamide to decrease the risk of bleeding from the bladder. (wikipedia.org)
  • If too much of it appears in the urine or if the urine stays in the bladder too long, it can cause dangerous irritation. (canadianpharm.org)
  • The tablet should be swallowed whole, and plenty of fluids should be consumed to pass urine frequently and reduce the risk of kidney or bladder problems. (onlinepharmaciescanada.com)
  • If you continue to notice blood in your urine or if your symptoms persist after a course of antibiotics for a UTI, it may be a sign of something more, like bladder cancer. (onteenstoday.com)
  • Blood in the urine doesn't always mean you have bladder cancer. (onteenstoday.com)
  • Bloody urine may be due to a problem in your kidneys or other parts of the urinary tract, such as: Cancer of the bladder or kidney. (steadyprintshop.com)
  • A bladder infection may cause pelvic pain, increased urge to urinate, pain with urination and blood in the urine. (unittas.in)
  • If there is any obstruction of urine due to small urethral stones or bladder stones then they can be removed by doing the cystoscopy. (miracleshealthclinic.com)
Metabolites5
  • The metabolites are then excreted in the urine. (wikipedia.org)
  • Up to 30% of dogs (depending on the study) receiving cyclophosphamide for over 2 months develop bloody urine caused by excretion of irritating cyclophophamide metabolites. (marvistavet.com)
  • and (2) to assess the efficacy of these methods by determining the biological half-lives of the urinary metabolites of cyclophosphamide, cytarabine, daunorubicin and adriamycin. (leonmayerfund.org)
  • The first aim is to develop a chemical shift editing procedure for the detection of cyclophosphamide metabolites in urine. (leonmayerfund.org)
  • New findings have resulted in the development of more sensitive methods for the analysis of individual cytostatic drugs or their metabolites mainly in urine. (gerpac.eu)
Excretion6
  • The occupational exposure of 21 nurses and pharmacy personnel from eight hospitals to cyclophosphamide and ifosfamide was determined by quantifying the amount of the drugs handled and by measuring the urinary excretion of the unmetabolised substances. (bmj.com)
  • Excretion of cyclophosphamide ranged from 3.5 to 38 micrograms/24 h (mean 11.4 micrograms/24 h) urine, ifosfamide from 5 to 12.7 micrograms/24 h (mean 9 micrograms/24 h) urine. (bmj.com)
  • Based on an excretion rate of 11.3% unmetabolised cyclophosphamide, the average amount excreted corresponded to an uptake of 101 micrograms cyclophosphamide. (bmj.com)
  • Phenobarbital will increase the rate of excretion of cyclophosphamide (i.e. cyclophosphamide will be more rapidly removed from the body). (marvistavet.com)
  • In addition, excretion of cyclophosphamide has not been found anymore indicating no measure exposure to this drug. (gerpac.eu)
  • In the final 'traffic-light' model can easily be seen what levels of cyclophosphamide regarding environmental contamination and urine excretion are acceptable or not and what actions have to be performed. (gerpac.eu)
Dose6
  • Your doctor may need to delay your treatment or adjust your dose of cyclophosphamide depending on your response to treatment and any side effects that you experience. (medlineplus.gov)
  • If you vomit shortly after taking a dose of cyclophosphamide, check with your doctor. (canadianpharm.org)
  • White cell blood lines show suppression (i.e. counts will drop) approximately 1-2 weeks following a dose of cyclophosphamide. (marvistavet.com)
  • Other oncologists do not like to reduce the cyclophosphamide dose without evidence of infection as reducing the cyclophosphamide dose will give the tumor an advantage and possibly jeopardize the remission. (marvistavet.com)
  • Patients with creatinine clearances of approximately 60 mL/min or greater excrete 65% of the dose in the urine within 12 hours and 71% of the dose within 24 hours. (nih.gov)
  • Exposure to cyclophosphamide or any biologic lupus therapy within 8 weeks prior to the first dose of study drug. (who.int)
Microscopic2
  • Symptoms can include a persistent urge to urinate, pain and burning with urination, and extremely strong-smelling urine.For some people, especially older adults, the only sign of illness might be microscopic blood in the urine. (unittas.in)
  • Urine analysis test is done by doing a microscopic examination of urine. (miracleshealthclinic.com)
Dexamethasone1
  • In the treatment of immune mediated disease, it is common and usual to use cyclophosphamide in conjunction with corticosteroids (such as prednisone or dexamethasone ). (marvistavet.com)
Nausea2
Toxicity2
  • This will increase the toxicity potential of the cyclophosphamide. (marvistavet.com)
  • This rate will increase the toxicity potential of the cyclophosphamide. (vin.com)
Infection5
  • Other analyses, such as antinuclear antibody testing, blood and urine cultures, and serologic assays against Coxiella burnetii , herpes virus, cytomegalovirus, and Epstein-Barr virus, did not indicate acute infection. (cdc.gov)
  • Based on its oral administration and the reduced incidence of infection and cytopenia, cyclophosphamide-thalidomide-dexa-methasone may be considered an effective induction therapy option for patients with newly diagnosed multiple myeloma. (haematologica.org)
  • Why would I have blood in my urine but no infection? (onteenstoday.com)
  • How long can a urine infection last? (onteenstoday.com)
  • Reactivation of infection such as tuberculosis (TB) and hepatitis B may happen when you are on medication, hence, your doctor will check for such infection before starting cyclophosphamide. (nhcs.com.sg)
Protein in the urine3
  • High blood pressure and the presence of protein in the urine may predict the tendency towards progression. (renalconsultants.com)
  • Of the 309 patients who completed the run-in phase, 94 patients were categorized as low risk, defined as less than 0.75 g/day of protein in the urine, and were therefore excluded from the analysis. (medscape.com)
  • The remaining 162 patients with persistent proteinuria, defined as more than 0.75 g/day of protein in the urine, were randomized to supportive therapy alone or to supportive therapy plus immunosuppression for 3 years. (medscape.com)
Medications7
  • Cyclophosphamide is also used to treat nephrotic syndrome (a disease that is caused by damage to the kidneys) in children whose disease has not improved, has gotten worse, or has come back after taking other medications or in children who experienced intolerable side effects with other medications. (medlineplus.gov)
  • Cyclophosphamide is in a class of medications called alkylating agents. (medlineplus.gov)
  • Many other medications may also interact with cyclophosphamide, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. (medlineplus.gov)
  • Certain medications, including phenazopyridine (Pyridium), a drug that numbs urinary tract discomfort, and over-the-counter laxatives that contain senna can turn your urine reddish-orange, she says. (besthealthmag.ca)
  • Special consideration should be used when cyclophosphamide is given to patients taking additional medications with bone marrow suppressing potential. (marvistavet.com)
  • This is because cyclophosphamide may make you more sensitive to certain medications and procedures, and it may also increase your risk of bleeding during surgery. (onlinepharmaciescanada.com)
  • Cyclophosphamide belongs to a class of medications called immunosuppressant. (nhcs.com.sg)
Kidneys2
  • The kidneys pass large amounts of protein (the urine may be "frothy") into the urine and this means the water in the blood stream passes into the tissues, particularly the feet and around the eyes. (renalconsultants.com)
  • His kidneys started failing, and doctors at Froedtert Hospital in Milwaukee started him on a regimen of immunosuppressants and cyclophosphamide. (oncoloblogy.com)
Lupus nephritis2
  • Many nephrologists, myself included, are eager to find alternatives to cyclophosphamide in the management of lupus nephritis. (ukidney.com)
  • Several studies have suggested that mycophenolate mofetil (MMF) may be superior and less toxic than cyclophosphamide in the management of lupus nephritis. (ukidney.com)
Pass more urine2
  • While you are using cyclophosphamide, it is important that you drink extra fluids so that you will pass more urine. (canadianpharm.org)
  • It is advised that you drink extra fluids so that you pass more urine. (unisoulpharma.com)
Plasma and urine1
  • 13. Scherrmann J. Prognostic value of plasma and urine paraquat concentration. (ac.ir)
Antibiotic2
  • Conversely, the antibiotic chloramphenicol may reduce the metabolism of cyclophosphamide thereby increasing its potency. (marvistavet.com)
  • Some drugs, like the antibiotic penicillin or the cancer drug cyclophosphamide, can cause blood in your urine. (steadyprintshop.com)
Doses2
  • Pertaining to the doses handled, the uptake of cyclophosphamide and ifosfamide was estimated to be approximately 0.0025% and 0.0004% respectively. (bmj.com)
  • Her family physician began treatment with metamizole and cefuroxime at usual doses because of urine sediment alterations. (cdc.gov)
Patients7
  • Colony-stimulating factor (CSF) was partially purified from urine of patients with aplastic anemia using DEAE-cellulose and concanavalin A-Sepharose. (eurekamag.com)
  • Patients who undergo hematopoietic stem cell transplantation frequently have hemorrhagic cystitis because most are exposed to cyclophosphamide, total-body irradiation, or both. (medscape.com)
  • Cyclophosphamide is a antineoplastic , immunosuppressive agent that is FDA approved for the treatment of malignant diseases , minimal change nephrotic syndrome in pediatric patients. (wikidoc.org)
  • In a 24-week open-label induction study of 370 patients with class III-V lupus, there were no differences in the primary end-point (a prespecified decrease in urine protein/creatinine ratio and stabilization or improvement in serum creatinine) or the secondary end-point (complete renal remission, systemic disease activity and damage, and safety). (ukidney.com)
  • For the studied patients, IV cyclophosphamide and oral MMF share similar efficacy and harm. (ukidney.com)
  • Pulse therapy with cyclophosphamide and methylprednisolone in patients with moderate to severe paraquat poisoning: a preliminary report. (ac.ir)
  • Depending on renal function, patients received either corticosteroids alone or in combination with other immunosuppressive agents, such as cyclophosphamide and azathioprine . (medscape.com)
Hemorrhagic2
  • Cyclophosphamide is the most common cause of hemorrhagic cystitis in the oncologic population. (medscape.com)
  • Classic hemorrhagic cystitis is most commonly seen as a side effect of cyclophosphamide, especially if it is combined with radiation therapy . (medscape.com)
Blood24
39001
  • Twenty four hour urine was collected on days when cyclophosphamide and/or ifosfamide were mixed, on average 3900 mg cyclophosphamide and/or 5900 mg ifosfamide. (bmj.com)
Mesna1
  • Mesna is a water-soluble compound with antioxidant properties, and is given concomitantly with the chemotherapeutic agents cyclophosphamide and ifosfamide. (wikipedia.org)
Doctor's1
  • While you are being treated with cyclophosphamide, and after you stop treatment with it, do not have any immunizations (vaccinations) without your doctor's approval. (canadianolpharmacy.com)
Corticosteroids1
  • Initial management consisted of en una paciente con topical corticosteroids and oral antihistamines with little clinical response. (bvsalud.org)
Bloody1
  • This is a serious side effect of cyclophosphamide use and any sign of bloody urine should be reported to the veterinarian at once. (marvistavet.com)
Liver3
  • The urotoxicity observed with cyclophosphamide is due to its liver metabolite acrolein, which is excreted in the urine. (medscape.com)
  • Cyclophosphamide needs metabolic activation in the liver in order to have a cytostatic effect. (vin.com)
  • Its active substance cyclophosphamide is converted in the liver by cytochrome P450 into two active substances acrolein and phosphoramide. (canadianfpharmacy.com)
Albumin3
  • Laboratory assessment revealed the following: haemoglobin (Hb) 7.4 g/dL (74 g/L), creatinine 2 mg/dL (177 μM/L) and albumin 2.1 g/dL (21 g/L). Urine analysis showed 3+ albumin, granular casts, no ova and urine protein/creatinine ratio of 3.5 g/g. (who.int)
  • In of 2017 January, the individual was examined for 2 weeks of intensifying lower extremity edema and was discovered to really ENMD-2076 Tartrate have the nephrotic symptoms with an area urine albumin:creatinine percentage of 7?g/g and a serum albumin of 2.1?g/dL. (estme.org)
  • 21 g/L). Urine analysis showed 3+ which is endemic in the subtropics, albumin, granular casts, no ova and affecting almost 200 million people urine protein/creatinine ratio of 3.5 worldwide. (who.int)
Cancer10
  • When cyclophosphamide is used to treat cancer, it works by slowing or stopping the growth of cancer cells in your body. (medlineplus.gov)
  • One uses cyclophosphamide to kill cells that are causing harm, usually cancer cells or inflammatory cells. (marvistavet.com)
  • Cyclophosphamide is often used to slow or halt the spread of cancer cells, which can lead to an improved prognosis. (onlinepharmaciescanada.com)
  • Cyclophosphamide works by interfering with cell division, preventing cancer cells from dividing and multiplying. (onlinepharmaciescanada.com)
  • Veterinarians use cyclophosphamide to kill cells that are causing harm, usually cancer cells or inflammatory cells. (vin.com)
  • Cyclophosphamide/Alkylating Agent Concept/Action/Use Assessment Immunity CCNS Damage cell's DNA preventing reproduction of cancer cells. (studylib.net)
  • What side effects can Cyclophosphamide (Non-Cancer) cause? (nhcs.com.sg)
  • Before taking Cyclophosphamide (Non-Cancer) , what precautions must I follow? (nhcs.com.sg)
  • How should Cyclophosphamide (Non-Cancer) be used? (nhcs.com.sg)
  • In addition, these data can also be linked to cancer risk estimates in terms of strive risk level and prohibitory risk level based on the analysis of cyclophosphamide in urine of healthcare workers. (gerpac.eu)
Nephrotic1
Treatment5
  • Intravenous pulse administration of cyclophosphamide (CYC) has been successfully used for the treatment of various autoimmune diseases. (nih.gov)
  • The medicine is red in color, and it turns urine red for several hours after treatment. (aultcare.com)
  • 12. Newstead C. Cyclophosphamide treatment of paraquat poisoning. (ac.ir)
  • There was a median reduction of 50.7% in 24-hour urine protein after 16 weeks of treatment with filgotinib (n=4), and the median Systemic Lupus Erythematosus Disease Activity Index from the Safety of Estrogens in Lupus National Assessment score remained stable. (bmj.com)
  • Four months into the treatment, he submitted a urine sample to have his body's protein loss measured, and that same evening, the doctor from Froedtert called. (oncoloblogy.com)
Precautions1
  • Despite standard safety precautions, including a vertical laminar air flow safety cabinet and gloves, cyclophosphamide was detected in 12 of 31 and ifosfamide in four of 21 urine samples on days when the drugs were handled. (bmj.com)
Orally2
  • Cyclophosphamide should be taken orally in tablet form, preferably with a meal to avoid stomach upset. (onlinepharmaciescanada.com)
  • Patient's condition improved over period of time, she started accepting orally and urine output was adequate. (ac.ir)
Colour7
  • Your urine colour can sometimes be a surprise, whether it's bright yellow or even red or violet. (besthealthmag.ca)
  • Plus, a urine colour chart to help you understand what your pee colour means. (besthealthmag.ca)
  • What colour should urine or pee be? (besthealthmag.ca)
  • Yellow is the colour we normally associate with urine, but there are shades of yellow. (besthealthmag.ca)
  • However, many people refer to urine without a strong colour as "clear," when the actual word they mean is colourless or diluted. (besthealthmag.ca)
  • Nevertheless, the more water you drink, the less colour your urine has. (besthealthmag.ca)
  • If your urine is consistently clear, absent of colour, diluted, and occurs frequently, it could signify a health issue like kidney problems , diabetes, or overhydration. (besthealthmag.ca)
Baseline2
  • Baseline labs CBC, chemistry, and urine. (studylib.net)
  • The primary endpoint was the per cent change in 24-hour urine protein from baseline to week 16. (bmj.com)
UTIs1
Exposure3
  • The decline is not only observed for contamination but also for the amounts of drugs excreted in the urine of healthcare workers indicating a reduction of occupational exposure. (gerpac.eu)
  • The selection of cyclophosphamide was obvious : a highly toxic drug, resistant, high skin permeability (skin exposure), frequently used and monitored (wipe and urine samples) due to sensitive analytical methods. (gerpac.eu)
  • To follow and to support these developments, the use of monitoring methods by taking and analysing wipe and urine sample are a must and will remain a permanent tool for measuring contamination and exposure at healthcare sites. (gerpac.eu)
Biological1
  • Biological monitoring of cyclophosphamide and ifosfamide in urine of hospital personnel occupationally exposed to cytostatic drugs. (bmj.com)
Interfere1
  • Cyclophosphamide may interfere with normal menstrual cycles and sperm production, potentially leading to permanent infertility. (onlinepharmaciescanada.com)
Drugs1
  • Diuretics are drugs that promote urine production and output and can affect results. (uniprix.com)
Breakdown1
Tablet1
  • Cyclophosphamide comes as a tablet to take by mouth once a day. (medlineplus.gov)