• Blood and urine samples were collected from mice and blood glucose, serum creatinine, urinary albumin excretion and urinary β2‑microglobulin were measured. (spandidos-publications.com)
  • To date, no serum or urine marker has been shown to predict plaque instability and the risk of future cerebrovascular events. (whiterose.ac.uk)
  • Shifts in subcellular content of blood serum and urine at asthma: animal model, clinic and monitoring data]. (mysciencework.com)
  • We reproduced mouse model of bronchial asthma, evaluated metabolic shifts of serum homeostasis during disease development, and compared these results with the data on metabolic shifts in bronchial asthma patients. (mysciencework.com)
  • With serum lithium levels in the therapeutic range, rats produced a daily urine output that matched their own weight (149). (artscolumbia.org)
  • Recent study demonstrates, that serum Clusterin level increases significantly in diabetic type II patients and in patients with developing coronary heart disease, or myocardial infarction. (biovendor.com)
  • In patients with systemic lupus erythematosus (SLE), reduced serum Clusterin levels correlated inversely with disease activity. (biovendor.com)
  • Diabetes mellitus (DM) represents a group of metabolic diseases related to defective production, secretion, or activity of insulin resulting in hyperglycemia associated with deleterious effects on the life quality of patients [ 16 , 17 ], and it is frequently associated with complications that lead to multiple organ dysfunction. (hindawi.com)
  • The renal glomerulus represents the major filtration body of the vertebrate nephron and is responsible for urine production and a number of other functions such as metabolic waste elimination and the regulation of water, electrolyte and acid-base balance. (bvsalud.org)
  • Significant metabolic profile separations were found between control cohorts and animals with tumour burdens at all time-points for the intracerebral 4T1-GFP time-course. (ox.ac.uk)
  • Aims and methods: The aim of this study was to compare metabolic profiles of plasma and plaques from patients with symptomatic carotid stenosis undergoing endarterectomy, plasma and plaques from patients with symptomatic femoral stenosis, and plasma from patients without carotid or femoral disease (control). (whiterose.ac.uk)
  • Novel gene pathways important in diabetes and obesity have been identified by investigators at Northwestern, and a wide number of applications ranging from biomedical engineering to transplantation, regenerative medicine, inflammation, developmental biology, pharmacology, and neurobehavioral disorders suggest an increasing interest in technologies for phenotyping mouse metabolic systems. (northwestern.edu)
  • Maple syrup urine disease (MSUD) is rare autosomal recessive metabolic disorder caused by the dysfunction of the mitochondrial branched-chain 2-ketoacid dehydrogenase (BCKD) enzyme complex leading to massive accumulation of branched-chain amino acids and 2-keto acids. (stanford.edu)
  • Lipid storage diseases (also known as lipidoses) are a group of inherited metabolic disorders in which harmful amounts of fatty materials (lipids) accumulate in various cells and tissues in the body. (nih.gov)
  • Non-obese diabetic or NOD mice, like biobreeding rats, are used as an animal model for type 1 diabetes. (wikipedia.org)
  • 2022. Refinement of handling and dosing methods for rats and mice. (awionline.org)
  • Some of the renal protective effects of Fx were clarified in animal models with diabetes, such as db/db mice [ 8 ] and diabetic Zucker rats [ 9 ]. (hindawi.com)
  • Eight-week-old male Sprague-Dawley rats (Guangdong Medical Laboratory Animal Center, Foshan, China) weighing 200-220 g were adopted for this study. (hindawi.com)
  • However, treatment of lithium-diuretic rats with high doses of the specific V2-receptor agonist dDAVP was able to cause efficient delivery of AQP2 to the apical plasma membrane (a greater fraction of total AQP2 was found in the membrane than seen in control animals), but there was only a modest increase in AQP2 expression relative to animals treated with lithium alone. (artscolumbia.org)
  • Streptozotocin-Induced Diabetic Models in Mice and Rats. (scienceopen.com)
  • Detailed in this unit are protocols for producing STZ-induced insulin deficiency and hyperglycemia in mice and rats. (scienceopen.com)
  • In fact history has shown that whenever cats were demonized, the deadliest plagues almost wiped out the human race - since rats, not cats, carry deadly disease and breed more quickly than cats . (thedodo.com)
  • Cats need the amino acid taurine to maintain life, which is mainly found in mice and rats, which is their primary food of choice . (thedodo.com)
  • Plasma human experiment also showed weak models and could not confidently establish certain metabolites as atherosclerotic biomarkers. (whiterose.ac.uk)
  • However, similarities were observed between the animal and human models, and 3 metabolites (2-oxoglutarate, choline and taurine) were identified as potential biomarkers. (whiterose.ac.uk)
  • We performed the first characterization of a Bckdhb-/- mouse model, which recapitulates the severe human phenotype of MSUD with early-neonatal symptoms leading to death during the first week of life with massive accumulation of MSUD biomarkers. (stanford.edu)
  • Development and validation of biomarkers in tissue, blood and urine including circulating tumor cells. (lu.se)
  • By using zebrafish as a vertebrate in vivo model, we report a novel role of the Kinesin-like motor protein Kif21a in glomerular filtration. (bvsalud.org)
  • Podocytes, the key component of the glomerular filtration barrier (GFB), are gradually lost during the progression of diabetic kidney disease (DKD), severely compromising kidney functionality. (bvsalud.org)
  • APOL1 kidney risk variants in glomerular diseases modeled in transgenic mice. (nih.gov)
  • FSGS is a common glomerular disease in the United States, particularly among African American persons. (medscape.com)
  • The purpose of this study was to determine whether WNV is similarly shed in the urine of humans with WNV infections. (cdc.gov)
  • The U.S. Environmental Protection Agency considers TCE an animal carcinogen and a potential cancer hazard to humans. (cdc.gov)
  • Apparently, this is done to "model" multiple sclerosis-even though what happens in mice bears little resemblance to what happens in humans with the disease. (peta.org)
  • The resulting TcMAC21 mice have many characteristics indicative of Down syndrome in humans, including a distinct facial structure, a greater prevalence for congenital heart defects, a smaller-than-usual cerebellum and learning difficulties. (newswise.com)
  • To study this new cell culture approach, the researchers focused on bladder cancer in dogs, a disease which occurs at a rate similar to humans. (eurekalert.org)
  • We are confident that our method will make a breakthrough in bladder cancer diagnosis and treatment in both animals and humans, as it efficiently reduces the culture time, handling, gel, and media supplement costs, and therefore it can be an important platform for the development of new bladder cancer therapy," Usui said. (eurekalert.org)
  • We must remember that never in history have humans worshiped an animal as the Egyptians did the cat, because they knew cats were helping them survive. (thedodo.com)
  • whereas congenital malformations have been observed in humans as well as animals. (drugs.com)
  • MRLs include adjustments to reflect human variability and extrapolation of data from laboratory animals and humans. (cdc.gov)
  • No studies were located regarding the following health effects in humans or animals following inhalation exposure to diethyl phthalate. (cdc.gov)
  • Diabetic kidney disease (DKD) is a microvascular complication resulting from diabetes mellitus and represents the most prevalent cause of kidney failure, and ~30% of DKD cases will develop into renal failure ( 1 ). (spandidos-publications.com)
  • Currently, DKD diagnosis primarily relies on a patient's medical history of diabetes mellitus and laboratory tests, including urine glucose qualitative testing, blood glucose measurement and urine protein measurement. (spandidos-publications.com)
  • Diabetes develops in NOD mice as a result of insulitis, a leukocytic infiltrate of the pancreatic islets. (wikipedia.org)
  • NOD mice will develop spontaneous diabetes when left in a sterile environment. (wikipedia.org)
  • The incidence of spontaneous diabetes in the NOD mouse is 60-80% in females and 20-30% in males. (wikipedia.org)
  • Non-obese diabetic (NOD) mice exhibit a susceptibility to spontaneous development of autoimmune insulin dependent diabetes mellitus (IDDM). (wikipedia.org)
  • Environment including housing conditions, health status, and diet all affect development of diabetes in the mice. (wikipedia.org)
  • Diabetes in these mice can be prevented by a single injection of mycobacterial adjuvants such as complete Freund's adjuvant (FCA) or Bacille de Calmette et Guérin (BCG) vaccine. (wikipedia.org)
  • Genetic Loci associated with susceptibility to IDDM have been identified in the NOD mouse strain through the development of congenic mouse strains, which have identified several insulin dependent diabetes (Idd) loci. (wikipedia.org)
  • db/db mouse is a spontaneous type 2 diabetes model animal (single gene disorders). (or.jp)
  • This strain is a spontaneous type 2 diabetes model animal. (or.jp)
  • TSOD mouse is spontaneous type 2 diabetes model animals (multifactorial diseases). (or.jp)
  • In 1984, six animals, which were observed as obesity and diabetes, from ddY mice were accidentally discovered by Dr. Wataru Suzuki at the Tsumura & Co. With these male mice and ddY female mice, they were sib-mated repeatedly. (or.jp)
  • Male TSOD mouse spontaneously indicates obesity and diabetes with high probability, and plural genes participate in obesity and blood-sugar level. (or.jp)
  • Diabetes develops only in a male TSOD mouse, not female one. (or.jp)
  • Diabetes-associated kidney diseases are not uncommon for diabetic people. (diseasefix.com)
  • Diabetic kidney disease or diabetic nephropathy happens when the blood vessels and other cells present in the kidneys get damaged due to diabetes. (diseasefix.com)
  • The researchers at Mount Sinai School of Medicine evaluated mice who were genetically predisposed to type 1 or type 2 diabetes. (diseasefix.com)
  • Also, the kidney pathology of the model of type 2 diabetes was partially reversed on microscopic analysis. (diseasefix.com)
  • The mission of our core is to advance research across Northwestern in diabetes, obesity, and cardiovascular disease by establishing validated high-throughput hormone analyses and to create a consolidated reference center for efficient testing for the community. (northwestern.edu)
  • Several clinical studies using hypouricemic agents such as allopurinol showed positive outcomes such as improving renal damage and postponing renal failure in patients with either diabetes or chronic kidney disease (CKD) [ 6 ]. (hindawi.com)
  • Suitable animal models characterized by both diabetes and hyperuricemia should be explored for researches in this field. (hindawi.com)
  • While macrophage-induced inflammation is crucial for the response to pathogen infection, excessive or sustained inflammation can cause tissue damage and may lead to different conditions such as diabetes, cardiovascular diseases, and tumors 2 . (nature.com)
  • Streptozotocin (STZ) is an antibiotic that produces pancreatic islet β-cell destruction and is widely used experimentally to produce a model of type 1 diabetes mellitus (T1DM). (scienceopen.com)
  • Also described are protocols for creating animal models for type 2 diabetes using STZ. (scienceopen.com)
  • These animals are employed for assessing the pathological consequences of diabetes and for screening potential therapies for the treatment of this condition. (scienceopen.com)
  • Among a random sample of 1,634 older adult patients with RSV-associated hospitalization, 54.1% were aged ≥75 years, and the most common underlying medical conditions were obesity, chronic obstructive pulmonary disease, congestive heart failure, and diabetes. (cdc.gov)
  • Further tests showed that as liver function decreased, more SCC appeared in the animals' blood, and that SCC could compete for copper with the proteins that normally transport this mineral to the liver. (hopkinsmedicine.org)
  • The expression levels of fibrosis‑related proteins fibronectin, α‑smooth muscle actin and TGF‑β1 were observed to be decreased in kidney tissues of DKD mice following HPS treatment. (spandidos-publications.com)
  • Now, a follow-up investigation by the same team, in collaboration with researchers at 13 other medical institutions in the United States, has shown that two proteins found in deceased donor urine can be measured to define which donor organs - including those with AKI - are the best candidates for saving the lives of patients with kidney failure. (newswise.com)
  • Niemann-Pick disease type C is not caused by a deficiency of sphlingomyelinase but by a lack of the NPC1 or NPC2 proteins. (nih.gov)
  • proteins, rat and mouse urine proteins, latex (Hevea brasiliensis) and enzymes such as the baking additive fungal a-amylase usually derived from Aspergillus oryzae. (cdc.gov)
  • In addition, HPS treatment mitigated apoptosis and pathological damage in the kidney tissues of DKD mice. (spandidos-publications.com)
  • We also aim to compare plasma and solid tissues from mammalian model (mice), and further compare them to the human experiment. (whiterose.ac.uk)
  • APOL1 renal risk variants promote cholesterol accumulation in tissues and cultured macrophages from APOL1 transgenic mice. (nih.gov)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Urine metabolite composition was analysed by 1H NMR spectroscopy. (ox.ac.uk)
  • Hormones can be measured in various biological source materials: blood, feces, urine, saliva and others. (awionline.org)
  • Expired air samples were obtained until 4 hours after exposure, when mice were killed and samples for radioactivity were obtained from the skin depot, the skin under the depot, a wiping of the skin under the depot, the carcass, feces, urine, and cage washings. (cdc.gov)
  • Gene therapy for sickle cell disease , severe immunodeficiency (SCID-X), adrenoleukodystrophy , relapsed acute lymphoblastic leukemia , Wiskott-Aldrich syndrome , and a growing list of other conditions. (childrenshospital.org)
  • In a small percentage of patients, primarily the elderly and immunocompromised, disease progresses to a more severe form with central nervous system (CNS) involvement, including encephalitis and meningitis ( 4 , 5 ). (cdc.gov)
  • Models became stronger, with higher sensitivity and specificity, as the time-course progressed indicating a more severe tumour burden. (ox.ac.uk)
  • Alzheimer's disease (AD) is a chronic, progressive neurodegenerative disease leading to severe cognitive loss and eventual death. (frontiersin.org)
  • Successful treatment of severe MSUD in Bckdhb-/- mice with neonatal AAV gene therapy. (stanford.edu)
  • Injection in neonatal Bckdhb-/- mice at 1014 vg/kg achieved long-term rescue of the severe MSUD phenotype of Bckdhb-/- mice. (stanford.edu)
  • This infection can progress to HPS, a severe respiratory disease that was first identified in 1993 in the southwestern United States. (blogspot.com)
  • Nine monkeys became infected and seven developed severe disease. (blogspot.com)
  • Another defining prominent function of Clusterin is its induction in many severe physiological disturbances states including kidney degenerative diseases, prostate and vesicle carcinogenesis, ovarian cancer and several neurodegenerative conditions (Alzheimer's disease). (biovendor.com)
  • These data highlight the importance of prioritizing those at highest risk for severe RSV disease and suggest that clinicians and patients consider age (particularly age ≥75 years), long-term care facility residence, and underlying medical conditions, including chronic obstructive pulmonary disease and congestive heart failure, in shared clinical decision-making when offering RSV vaccine to adults aged ≥60 years. (cdc.gov)
  • Adults aged ≥65 years remain at elevated risk for severe COVID-19 disease and have higher COVID-19-associated hospitalization rates compared with those in younger age groups. (cdc.gov)
  • suPAR is the soluble form of this receptor that correlates with activation of the immune system and is more elevated in very active and severe forms of disease. (medscape.com)
  • By comparing this score with how well each strain infected bladders in a standard female mouse model, the researchers determined that having a higher PUF gene score did not correlate with either strength (robust, variable, or deficient) of an acute infection, or with the ability to cause chronic infection in one mouse model. (nih.gov)
  • Chronic kidney disease (CKD) is common and the cause of significant morbidity and mortality. (wjgnet.com)
  • Complement activation occurs in progressive chronic kidney disease and may contribute to the chronic inflammation that is characteristically found in the kidney. (wjgnet.com)
  • One of the most common causes for patients entering into chronic dialysis and end-stage renal diseases is diabetic nephropathy. (diseasefix.com)
  • Aryl Hydrocarbon Receptor Mechanisms Affecting Chronic Kidney Disease. (nih.gov)
  • The worldwide prevalence of chronic kidney disease (CKD) has reached epidemic proportions over the last two decades. (oncotarget.com)
  • Symptoms are colic caused by stones and perhaps urinary infection or the sequela of chronic kidney disease. (msdmanuals.com)
  • Many research studies have highlighted the positive effects of natural flavonoids on chronic diseases, including PCa. (mdpi.com)
  • Non-alcoholic fatty liver disease (NAFLD) is recognized as a major chronic liver disease. (creative-proteomics.com)
  • In May 2023, two RSV vaccines were approved for prevention of RSV lower respiratory tract disease in adults aged ≥60 years. (cdc.gov)
  • Specifically, hESC-MSC treatment prevented disease-associated interstitial inflammation, protein cast deposition and infiltration of CD3 + lymphocytes in the kidneys. (nature.com)
  • Oxidative stress was markedly attenuated by iPS-MSCs both in AN mice and in protein-overloaded tubular cells. (oncotarget.com)
  • In this model, there is equilibrium between native (N) and denatured (D) states, represented by the equilibrium constant below: (1) As a protein undergoes thermal denaturation in the DSC, the heat capacity (C p (T)) of the sample chamber changes as the fraction of unfolded protein changes: (2). (centralparkcarriagesofficial.org)
  • However, as is discussed, the degree of AQP2 downregulation as well as the intracellular localization of the protein differs significantly among the various conditions, suggesting that different mechanisms are responsible for AQP2 dysregulation in the various models. (artscolumbia.org)
  • The seeds are rich in protein, and the plant is grown as animal forage. (drugs.com)
  • The protein is constitutively secreted by a number of cell types including epithelial and neuronal cells and is a major protein in physiological fluids including plasma, milk, urine, cerebrospinal fluid and semen. (biovendor.com)
  • The pharmacodynamic study modelled the relationships between antibiotic exposure and AMR emergence over time for various classes of agents. (europa.eu)
  • Rilzabrutinib is an oral, reversible, covalent BTK inhibitor designed for immune-mediated diseases. (aai.org)
  • NIAID conducts and supports research-at NIH, throughout the United States, and worldwide-to study the causes of infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating these illnesses. (blogspot.com)
  • People become infected with hantaviruses by inhaling virus from the urine, droppings or saliva of infected rodents. (blogspot.com)
  • Niemann-Pick disease is a group of autosomal recessive disorders caused by an accumulation of fat and cholesterol in cells of the liver, spleen, bone marrow, lungs, and, in some instances, brain. (nih.gov)
  • Eventually the animals' livers regenerate and liver function improves and with this the researchers expected to see less urinary copper. (hopkinsmedicine.org)
  • However, at this stage in the disease, urinary copper in the animal models continued to increase. (hopkinsmedicine.org)
  • Together, these findings suggest that liver cell death isn't the main source of urinary copper in Wilson's disease. (hopkinsmedicine.org)
  • These findings demonstrate that brain metastases can be diagnosed in an animal model based on urinary metabolomics from micrometastatic stages. (ox.ac.uk)
  • Another interesting observation obtained in rat model suggests that measurement of urinary Clusterin levels may be a useful clinical marker for the severity of renal tubular damage. (biovendor.com)
  • As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. (oncotarget.com)
  • 2022. Non-invasive assessment of mild stress-induced hyperthermia by infrared thermography in laboratory mice. (awionline.org)
  • 2022. Comparison of gelatin flavors for oral dosing of C57BL/6J and FVB/N mice. (awionline.org)
  • 2022. A quick and low-intensity method for oral administration to large numbers of mice: A possible alternative to oral gavage. (awionline.org)
  • Here, we show that hESC-MSCs prevent the progression of fatal lupus nephritis (LN) in NZB/W F1 (BWF1) mice. (nature.com)
  • When Ca2+ is dysregulated, it leads to the occurrence and progression of various diseases, such as focal segmental glomerulosclerosis, diabetic kidney disease, lupus nephritis, transplant glomerulopathy, and hypertensive renal injury. (bvsalud.org)
  • In this review we discuss current evidence that complement activation contributes to progression of CKD, how complement could cause renal inflammation and whether complement inhibition would slow progression of renal disease. (wjgnet.com)
  • Comprehensive proteomic quantification of bladder stone progression in a cystinuric mouse model using data-independent acquisitions. (ucsf.edu)
  • Much attention has focused on suPAR, in that prior studies have identified that high levels of suPAR are associated with states of poorer kidney function and can predict progression of disease. (medscape.com)
  • Drug administration to experimental rodents is often invasive and stressful, thus reducing animal welfare and potentially confounding experimental results. (awionline.org)
  • Just the smell of a cat's urine will keep rodents away. (thedodo.com)
  • Alzheimer's disease (AD) is a progressive neurodegenerative disorder resulting in dementia and eventual death. (frontiersin.org)
  • This figure shows known associations with Alzheimer's disease. (frontiersin.org)
  • Urine Single-Cell RNA Sequencing in Focal Segmental Glomerulosclerosis Reveals Inflammatory Signatures. (nih.gov)
  • this can be carried out using urine glucose dipsticks. (wikipedia.org)
  • We found that MAGI2 expression was downregulated in podocytes cultured with high-glucose in vitro, and in kidneys of db/db mice as well as DKD patients. (bvsalud.org)
  • We evaluated the role of insulin in inflammatory parameters in diabetic and nondiabetic mice using a systemic mycosis Paracoccidioides brasiliensis (Pb) model. (hindawi.com)
  • Exome sequencing initiatives for epilepsy , inflammatory bowel disease , and more. (childrenshospital.org)
  • Experimenters injected mice with a chemical that caused an inflammatory disease of the central nervous system, which left them struggling to walk and dragging their hind legs. (peta.org)
  • This study aims to explore the energy metabolism of macrophages under either inflammatory or anti-inflammatory conditions by adding LPS and Met, respectively, using an in vitro and an in vivo model. (nature.com)
  • Metal allergy is an inflammatory disease categorized as a delayed-type hypersensitivity (DTH) reaction. (mdpi.com)
  • Did you ever wonder why kidney diseases that didn't appear to be inflammatory when you biopsied and looked at them under the microscope responded clinically to immunosuppressives? (medscape.com)
  • To verify this explanation, she and her colleagues examined mice genetically modified to have Wilson's disease. (hopkinsmedicine.org)
  • However, the investigators found that mice that differed genetically reacted differently to infection-for example, two bacterial strains that caused robust bladder infection in one mouse model were much less effective in a second mouse model. (nih.gov)
  • Diabetic C57BL-6 mice and controls were infected with Pb18 and treated with insulin for 12 days prior to experiments. (hindawi.com)
  • Insulin treatment restored the leukocyte number in PeLF and restored the presence of B lymphocytes, dendritic cells, and NK cells in lungs of diabetic animals. (hindawi.com)
  • The data suggest that diabetic mice present impaired immunological response to Pb18 infection and insulin modulates inflammation by reducing IL-6 levels in lung and CINC-1 levels in spleen and liver homogenates, restoring leukocyte concentrations in PeLF and also restoring populations of dendritic cells and B lymphocytes in lungs of diabetic mice, permitting the host to better control the infection. (hindawi.com)
  • The Manton Center for Rare Disease Research and the Children's Rare Disease Cohorts initiative to help solve patients' genetic mysteries and begin to develop treatments. (childrenshospital.org)
  • The Precision Link Biobank for Health Discovery , a library of blood, tissue, and cells donated by thousands of patients and their families at Boston Children's Hospital to advance knowledge of health and disease. (childrenshospital.org)
  • In patients with progressive CKD there is histological evidence of inflammation in the interstitium and strategies that reduce inflammation reduce renal injury in pre-clinical models of CKD. (wjgnet.com)
  • For the human experiment, carotid and femoral plaques alongside plasma and urine samples were collected from 84 patients. (whiterose.ac.uk)
  • Patients with early-stage diabetic kidney disease can protect their kidneys by taking several steps like maintaining their blood sugar levels as much as possible. (diseasefix.com)
  • Primaquine phosphate is contraindicated in acutely ill patients suffering from systemic disease manifested by tendency to granulocytopenia, such as rheumatoid arthritis and lupus erythematosus. (nih.gov)
  • Patients must be informed of the potential for adverse genetic and reproductive effects associated with primaquine treatment (see PRECAUTIONS, Carcinogenesis, Mutagenesis, and Impairment of Fertility and Animal Pharmacology and/or Animal Toxicology ). (nih.gov)
  • Since pharmaceutical interest in this disease is low, two EU-supported projects (EURAMAN and HUE-MAN) within the 5th and 6th framework program, respectively have worked towards developing the recombinant human enzyme (rhLAMAN) as a therapeutic agent for patients suffering from alpha-Mannosidosis. (europa.eu)
  • High levels of circulating cytomegalovirus DNA reflect visceral organ disease in viremic immunosuppressed patients other than marrow recipients. (centralparkcarriagesofficial.org)
  • Researchers have attempted to elucidate the mechanisms of metal allergy using animal models and human patients. (mdpi.com)
  • Dr. Colella is committed to researching innovative ways to combat genetic diseases and making a positive impact on the lives of patients. (stanford.edu)
  • Outbreaks of infectious disease, like a group of people who get sick from contaminated food or a cluster of hospitalized patients acquiring an infection. (cdc.gov)
  • A standardized hydroalcoholic extract of fenugreek seeds is available, and a trial evaluated its use in patients with Parkinson disease at 300 mg twice daily for a period of 6 months. (drugs.com)
  • Now, Johns Hopkins Medicine researchers and their collaborators have created and characterized a new mouse replica of Down syndrome, long considered one of the most challenging disorders to simulate in laboratory animals. (newswise.com)
  • The following laboratory animals are available at IAR. (or.jp)
  • Laboratory Animals 56(2), 185-190. (awionline.org)
  • Laboratory Animals 55(1), 76-80. (awionline.org)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • Good afternoon, I'm Loretta Jackson-Brown and I'm representing the Clinician Outreach and Communication Activity (COCA) with the Emergency Risk Communication Branch at the Centers for Disease Control and Prevention. (cdc.gov)
  • Dr. Oliver is an Epidemic Intelligence Service Officer in the Division of Viral Diseases at the Centers for Disease Control and Prevention. (cdc.gov)
  • Dr. Russell is an Epidemic Intelligence Service Officer in the Influenza Division at the Centers for Disease Control and Prevention. (cdc.gov)
  • The MMWR series of publications is published by the Epidemiology Program Office, Centers for Disease Control and Prevention (CDC), U.S. Department of Health and Human Services, Atlanta, GA 30333. (cdc.gov)
  • Complement activation is known to occur in many diverse renal diseases, including glomerulonephritis, thrombotic microangiopathies and transplant rejection. (wjgnet.com)
  • The lysosomal storage disorder (LSD) alpha-Mannosidosis is a rare genetic disease and according to the EU regulations, designated as an "orphan" disease. (europa.eu)
  • She is currently Research Scientist at Stanford University, where she is developing innovative cell therapy approaches to address neuropathic lysosomal storage diseases (LSDs) using hematopoietic stem cell transplantation (HSCT) and genome editing. (stanford.edu)
  • Disorders in which intracellular material that cannot be metabolized is stored in lysosomes are called lysosomal storage diseases. (nih.gov)
  • Additionally, the researchers found no increased urine concentrations of other minerals stored in liver cells, which would be expected if these cells were releasing all their entire contents and not just copper. (hopkinsmedicine.org)
  • In many diseases, higher concentrations of MDA, HNE and 15(S)-8-iso-PGF2α are measured in biological samples as compared to health. (scienceopen.com)
  • Diagnosis is by measurement of cystine excretion in the urine. (msdmanuals.com)
  • Furthermore, they are more soluble than cystine in urine, and their increased excretion does not result in crystal or stone formation. (msdmanuals.com)
  • Excretion rate in expired air was fastest during the first 15 minutes of exposure except in mice treated with toluene or ethylbenzene, which demonstrated maximal excretion rate during the second 15 minutes after exposure. (cdc.gov)
  • A two compartment model was suggested by the initial rapid and subsequent gradual decay of expired breath excretion. (cdc.gov)
  • The mice (as well as C57BL/6 and SJL) are known to carry IgG2c allele. (wikipedia.org)
  • Moreover, 8-week-old C57BL/6J mice were intraperitoneally injected with LPS and Met to assess the mitochondrial response in vivo. (nature.com)
  • Amyotrophic lateral sclerosis (ALS) is the most common degenerative disease of the motor neuron system. (medscape.com)
  • Probabilistic exposure modeling that used NHANES dietary data from 2003-2004 coupled with duplicate diet and biomarker measurements estimated that the major contributors to dietary inorganic arsenic intake are vegetables (24%), fruit juices and fruits (18%), and rice (17%) (Xue et al. (nationalacademies.org)
  • An cordance (i.e. lack of response or exposure to a given IARC Group 1 integral consideration for the devel- common responses between spe- human carcinogen (see Chapter 21, opment and use of these models is cies). (who.int)
  • It is generally accepted that asthma is a disease in facilitated the evaluation of exposure response relationships which exposure to chemical and biological agents, such for bakery workers, exposed to wheat allergens and fungal as allergens and irritants, plays an important role [1]. (cdc.gov)
  • Exposure control has usually been based on trial and error approaches because safe levels below which the allergic disease does not develop have not been identi®ed for most allergens. (cdc.gov)
  • This information, along with data on ZDV efficacy in preventing perinatal transmission (3) and evidence that PEP prevented or ameliorated retroviral infection in some studies in animals (4), prompted a Public Health Service (PHS) interagency working group *, with expert consultation (5), in June 1996 to issue provisional recommendations for PEP for HCWs after occupational HIV exposure (6). (cdc.gov)
  • moreover, infectious WNV has been recovered from urine samples from experimentally infected hamsters as early as day 1 to day 52 postinfection ( 9 ). (cdc.gov)
  • Our model predicts that extracellular Cl − does not alter the apparent Ca 2+ affinity of TMEM16A, which we corroborated experimentally. (emory.edu)
  • Competing causes of mortali- or all of the animal species tested genetic variation, health status, life ty may prevent the development of experimentally. (who.int)
  • Early Diagnosis of Brain Metastases Using a Biofluids-Metabolomics Approach in Mice. (ox.ac.uk)
  • It is found that early diagnosis of diabetic nephropathy can help in stopping diabetic kidney disease and the associated damage. (diseasefix.com)
  • Prostate cancer (PCa) is a multifactorial disease with an unclear etiology. (mdpi.com)
  • Typically associated with distinct facial features and developmental delays, people with Down syndrome also experience difficulties with learning and memory, as well as higher rates of thyroid disease, blood and immune disorders and heart disease. (newswise.com)
  • May see lack of appetite, vomiting, diarrhea, dilated pupils (in cats), and seizures in animals with central nervous system (CNS) disorders, such as epilepsy. (petsupplies.com)
  • Do not use in animals with central nervous system (CNS) disorders, such as epilepsy, as it could possibly cause seizures. (petsupplies.com)
  • Human induced pluripotent stem cell-derived mesenchymal stem cells (iPS-MSCs) are emerging as attractive options for use in cell replacement therapy, but their effect in kidney diseases remains unknown. (oncotarget.com)
  • She completed a pediatric residency at Cincinnati's Children's Hospital Medical Center and a pediatric infectious disease fellowship at the University of Alabama at Birmingham. (cdc.gov)
  • However, a new study led by Johns Hopkins researchers and published June 22 in PLoS One suggests that when this route is impaired there's another exit route just for copper: A molecule sequesters only that mineral and routes it from the body through urine. (hopkinsmedicine.org)
  • The researchers, led by Svetlana Lutsenko, Ph.D., a professor of physiology at the Johns Hopkins University School of Medicine, found this additional copper escape hatch by studying an animal model of Wilson's disease, a rare disorder most often diagnosed in children. (hopkinsmedicine.org)
  • Delving deeper, the researchers gave the mice radioactive copper, which they could trace as it made its way through the body. (hopkinsmedicine.org)
  • To pursue this question, the researchers studied 21 representative E. coli strains obtained from the urine of 14 women who suffered from recurrent UTIs. (nih.gov)
  • The new model may help researchers better understand how people with Down syndrome learn and develop, and eventually, lead to new therapies for potentially deadly complications of the condition, such as heart disease and thyroid problems. (newswise.com)
  • This means that these mice, named TcMAC21 by the researchers, can be used relatively easily and at low cost in long-term experiments. (newswise.com)
  • The researchers caution that no single animal model can perfectly replicate a human condition. (newswise.com)
  • National Institutes of Health (NIH) researchers have developed an animal model of human hantavirus pulmonary syndrome (HPS) in rhesus macaques, an advance that may lead to treatments, vaccines and improved methods of diagnosing the disease. (blogspot.com)
  • The researchers then exposed 10 rhesus macaques to the virus derived from the newly infected deer mice. (blogspot.com)
  • Murine models of PCM have been used to study the several aspects of Pb infection, the outcomes varying from cure to a progressive granulomatous disease, according to the susceptibility of the strain of mice [ 15 ]. (hindawi.com)
  • The present study utilized db/db mice as a DKD animal model administered with low (30 mg/kg) and high doses (60 mg/kg) of HPS, in addition to glyburide (7.2 mg/kg). (spandidos-publications.com)
  • In a recent study, scientists sought to determine whether there is a universal "genetic signature(s)" defining the ability of UPEC to cause disease. (nih.gov)
  • Together, the study findings suggest that rather than a signature set of genes consistently determining virulence, a more complex and dynamic interplay between E. coli strains and their host environment determines infection and subsequent disease. (nih.gov)
  • Scientists across the globe often use mouse models in the study of human conditions to advance the pursuit of medicines and treatments. (newswise.com)
  • Further complicating the development of successful treatments is the lack of an accurate animal model to study the biology of Down syndrome and test potential therapies for conditions associated with it. (newswise.com)
  • However, they believe that the TcMAC21 mouse model developed in this study is a good starting point to create new and better strategies for helping people with Down syndrome. (newswise.com)
  • Taurine signals have been observed in the animal (plasma and solid) as well as human plasma models in this study. (whiterose.ac.uk)
  • Conclusions: Identifying plaque instability in asymptomatic carotid disease was the centre of this study. (whiterose.ac.uk)
  • Putative receptors that are responsible for rhLAMAN uptake into the brain across the Blood Brain Barrier were investigated and we were able to study the outcome of long-term ERT on the neuropathology and associated behavioural deficits observed in immune-tolerant alpha-Mannosidosis mice. (europa.eu)
  • Consequently, this study showed that thirsting was a more potent stimulus for AQP2 expression than dDAVP administration in the present model and provided evidence for the presence of a vasopressin-independent regulation of AQP2 expression levels. (artscolumbia.org)
  • In their study, NIAID scientists infected healthy deer mice with Sin Nombre virus obtained from descendants of wild deer mice. (blogspot.com)
  • However, this study is limited in that only two to six animals were tested at each dose level and no control data were presented. (cdc.gov)
  • It reviews reported analytical methods and their principles for the quantitative measurement of MDA, HNE and 15(S)-8-iso-PGF2α in biological samples including plasma and urine, and critically discusses their biological and biomedical outcome which is rarely crystal clear and free of artefacts. (scienceopen.com)
  • Experimenters at the Cleveland Clinic deliberately breed mice who are prone to pelvic organ prolapse-in which the uterus, bladder, or rectal tissue falls out of place and even protrudes outside the body. (peta.org)
  • In contrary, human solid tissue experiments have shown much stronger models and clearer results. (whiterose.ac.uk)
  • For example, lipin-1 is the major PAP in adipose tissue, and cardiac and skeletal muscle since lipin-1-deficient mice had little if any detectable PAP activity [2]. (aocs.org)
  • Mice lacking lipin-1 ( fld or fatty liver dystrophy) develop fatty livers and hypertriglyceridemia in the pre-weaning period, and are also devoid of mature adipose tissue [reviewed in 1]. (aocs.org)
  • As Postdoc she developed innovative in vivo AAV gene therapy approaches based on liver gene transfer or multi-tissue gene expression to target the multi-organ manifestations of Pompe disease, a LSD that presents with neuromuscular impairment. (stanford.edu)
  • lymphoid tissue, and digestive tract), which the animal model captures the It can be difficult to parse out concordance has often been ob- range of potential human response reasons for lack of tumour site con- served among different species after to the particular agent tested. (who.int)
  • The development of transgenic animal models across a broad number of laboratories at Northwestern University has increased the interest in studies of metabolism and cardiovascular physiology at multiple levels. (northwestern.edu)
  • NOD mice have a mutation in exon 2 of the CTLA-4 gene, which causes it to be spliced incorrectly. (wikipedia.org)
  • Nonclinical data from studies conducted in bacteria and in animals treated with primaquine show evidence of gene mutations and chromosomal/DNA damage, teratogenicity, and injury to embryos and developing fetuses when primaquine is administered to pregnant animals. (nih.gov)
  • Dr. Pasqualina Colella is a scientist with extensive expertise in cell therapy and gene therapy approaches for the treatment of inherited diseases. (stanford.edu)
  • We and others have tested AAV gene therapy in mice for two of the three genes involved in MSUD, BCKDHA and DBT. (stanford.edu)
  • Based on our previous experience in Bckdha-/- mice, we designed a transgene carrying the human BCKDHB gene under the control of a ubiquitous EF1α promoter, encapsidated in an AAV8 capsid. (stanford.edu)
  • All transplanted mice received a dose of lipopolysaccharide (LPS), which induces proteinuria in mice. (medscape.com)
  • In response to the LPS challenge, the mice that got the deficient bone marrow didn't develop proteinuria, whereas the mice that got the "uPAR-capable" bone marrow did. (medscape.com)
  • Irradiated mice had a blunted suPAR response to the LPS challenge, with diminished proteinuria. (medscape.com)
  • Regulation of a heart rhythm in mouse with asymptomatic and symptomatic models of Parkinson's disease]. (mysciencework.com)
  • Imbalance of the autonomic regulation of the heart occurs in asymptomatic the stage of Parkinson's disease. (mysciencework.com)
  • Bacterial strains that more robustly infected the mice correlated with markers of greater UTI severity in women, such as higher white blood cell counts in urine. (nih.gov)
  • Before shipping, we can measure blood sugar level and/or urine sugar and provide mice with certain range (charged). (or.jp)
  • Lowering systemic blood pressure has been repeatedly shown to change the course of diabetic kidney disease. (diseasefix.com)
  • High blood pressure can damage your kidneys by speeding up the process of diabetic kidney disease. (diseasefix.com)
  • Fasting blood and 24-h urine samples were collected every 4 weeks. (hindawi.com)
  • Systemic lupus erythematosus (SLE) is a debilitating multi-organ autoimmune disease that has no cure and limited treatment options 1 . (nature.com)
  • Do not use in animals hypersensitive (allergic) to it or other quinolone antibiotics and/or sulfonamides. (petsupplies.com)
  • PRNT tests were negative on urine samples obtained on days 8 and 15 after symptom onset. (cdc.gov)
  • Attempts at virus isolation, by using Vero cells (green monkey kidney cells) and C6/36 cells ( Aedes albopictus ), from urine samples collected on days 8, 11, 12, 13, 14, and 15 after symptom onset were unsuccessful. (cdc.gov)
  • For model organisms and plant and animal samples, no less than 10 are recommended. (creative-proteomics.com)
  • Human disease is typically characterized by a mild, self-resolving, denguelike illness with the onset of fever and myalgia ( 2 , 3 ). (cdc.gov)
  • However, the "structure, function, and behavior" of the mouse brain has little relevance to the human brain. (peta.org)
  • B16F10 melanoma and MDA231BR-GFP human breast carcinoma cells were used for additional modelling. (ox.ac.uk)
  • They did this by inserting a human copy of chromosome 21 into mice using the rodent's own cellular structures that organize DNA. (newswise.com)
  • This enables the mouse cells to reliably copy and sort the extra human chromosome into new cells as they divide. (newswise.com)
  • In line with our plans we have been able to demonstrate the safety and clinical efficacy of rhLAMAN as an effective therapeutic agent for treatment of the human disease alpha-Mannosidosis in clinical trial Phases 1 and 2. (europa.eu)
  • In the early stages, diabetic kidney disease is often asymptomatic, which makes it difficult to diagnose. (diseasefix.com)
  • Precision medicine" at Boston Children's begins with discoveries at the lab bench and ends with customized care based a patient's genetic profile and disease biology. (childrenshospital.org)
  • It also lets the mice pass the additional genetic material on to their offspring. (newswise.com)
  • Animals were injected with toxins that damaged their bodies, cut open with minimal pain relief, deliberately bred so that their internal organs would protrude outside their bodies, and kept in severely crowded cages. (peta.org)
  • Further mechanistic analysis revealed that the therapeutic effects of HPS on DKD mice may be mediated by inhibiting the high mobility group box 1/receptor for advanced glycation end‑products/toll‑like receptor 4 pathway. (spandidos-publications.com)
  • Ca2+ signaling is a promising therapeutic target for podocyte-related diseases. (bvsalud.org)
  • This review first summarizes the role of Ca2+ sensing, Ca2+ channels, and different Ca2+-signaling pathways in the biological functions of podocytes, then, explores the status of Ca2+ signaling in different podocyte-related diseases and its advances as a therapeutic target. (bvsalud.org)
  • APOL1 Nephropathy Risk Variants and Incident Cardiovascular Disease Events in Community-Dwelling Black Adults. (nih.gov)
  • A one-time cancer researcher, he's a founder of "biologically inspired engineering" - a new field that emulates nature's design principles to find new ways to tackle problems ranging from cardiovascular disease and cancer to energy efficient windows. (cosmosmagazine.com)
  • Cystine may appear in the urine as yellow-brown hexagonal crystals, which are diagnostic. (msdmanuals.com)
  • In pets taking enrofloxacin, dehydration increases the risk of seizures and crystals developing in the urine. (petsupplies.com)
  • In experimental mice pronounced pathological changes in the lungs, considerable lymphocytosis and decrease in neutrophil count were dete. (mysciencework.com)
  • Oral administration of medication to experimental animals is a cause of significant stress. (awionline.org)
  • Thus, based on this information, it would appear that diethyl phthalate is relatively nonlethal to orally exposed experimental animals. (cdc.gov)
  • She and her colleagues are now trying to learn more about SCC, both to identify this molecule and to determine whether it could be a unique marker that's only present during Wilson's disease. (hopkinsmedicine.org)
  • Metastatic mammary carcinoma cells (4T1-GFP) were injected into BALB/c mice via intracerebral, intracardiac or intravenous routes to induce differing cerebral and systemic tumour burdens. (ox.ac.uk)
  • Rilzabrutinib demonstrated dose-dependent improvement of clinical scores and joint pathology in a rat model of collagen-induced arthritis and demonstrated reductions in autoantibody-mediated FcγR signaling in vitro and in vivo, with blockade of rat Arthus reaction, kidney protection in mouse Ab-induced nephritis, and reduction in platelet loss in mouse immune thrombocytopenia. (aai.org)
  • In vitro studies and animal models. (lu.se)