• oxalosis
  • If transplantation is not possible, patients must be aggressively dialyzed, often 6 or 7 days per week and/or using a combination of modalities, in order to remove enough oxalate to prevent body-wide oxalosis. (mayo.edu)
  • As glomerular filtration rate declines due to progressive renal involvement, oxalate accumulates leading to systemic oxalosis. (tum.de)
  • tract
  • Endoscopy, using natural orifices, supported by anaesthesia, incremented by technology and with access to all points along the urinary tract, began by competing with ESWL, but is now the treatment of choice in most cases. (readbyqxmd.com)
  • The embryological link between the urinary tract, the genital system, and the gastrointestinal tract is the basis of the radiation of pain to the gonads, as well as the nausea and vomiting that are also common in urolithiasis. (wikipedia.org)
  • Once anchored, a particle can then grow until its dimensions become similar in magnitude to those of the urinary tract, i.e., millimeters to centimeters in diameter. (springer.com)
  • Roylance J, Penry JB, Rhys-Davies E, Roberts M: The radiology of tuberculosis of the urinary tract. (springer.com)
  • idiopathic
  • Idiopathic hypercalciuria is the most common cause of nephrolithiasis, and calcium oxalate stones are the most common type of stones in idiopathic hypercalciuric patients. (readbyqxmd.com)
  • The DCR-PHXC data demonstrate potent, durable, and precise knockdown of LDHA in animal models of PH1, PH2 and idiopathic PH (IPH), and show a simple, direct linear relationship between LDHA inhibition and oxalate production. (tmcnet.com)
  • glyoxylate
  • Deficiency or mistargeting of AGT* (PHI) results in buildup of glyoxylate and increased oxalate production. (mayo.edu)
  • Deficiency of a protein with dual GR and HPR ** activities (PHII) gives rise to increased hydroxypyruvate and glyoxylate, precursors of L-glycerate and oxalate, respectively. (mayo.edu)
  • Liver
  • A child with primary hyperoxaluria was treated with a liver and kidney transplant. (wikipedia.org)
  • Liver-kidney simultaneous transplantation in adult patients with primary hyperoxaluria. (readbyqxmd.com)
  • DCR-PHXC, the lead investigational product candidate in Dicerna's pipeline of therapies targeting rare diseases of the liver, yields potent, liver-specific LDHA inhibition in animal models of PH, an effect that reduces oxalate to near-normal levels, which may prevent the damage caused to kidneys and other organs by oxalate accumulation. (tmcnet.com)
  • By reducing LDHA activity in the liver in animal models of PH, DCR-PHXC silences what appears to be the only pathway that is a significant producer of oxalate in all forms of primary hyperoxaluria, and seems to do so without inducing any significant liver adverse effects. (tmcnet.com)
  • nephrocalcinosis
  • Nocturia, polyuria, and polydipsia from reduced urinary concentrating capacity (i.e. nephrogenic diabetes insipidus) as can be seen in hypercalcemia, medullary nephrocalcinosis of any cause, or in children with Bartter syndrome in whom essential tubular salt reabsorption is compromised. (wikipedia.org)
  • Nephrocalcinosis is caused by an increase in the urinary excretion of calcium, phosphate, and/or oxalate. (wikipedia.org)
  • patients
  • Recently, a third group of patients has been identified with an as-yet-unknown genetic cause of hyperoxaluria. (mayo.edu)
  • In stone-forming patients high urinary oxalate values, sometimes even in the upper limit of the normal range, are treated to reduce the risk of stone formation. (testcatalog.org)
  • Williams RE: Long-term survey of 538 patients with upper urinary stone. (springer.com)
  • therapeutic
  • These research findings are particularly exciting as they show that inhibition of LDHA reduces oxalate production in animal models of all forms of primary hyperoxaluria, establishing LDHA as a potentially ideal therapeutic target and opening the door to a new treatment approach for this family of diseases," noted Douglas Fambrough, Ph.D., president and chief executive officer of Dicerna. (tmcnet.com)
  • sodium
  • Either name is often used for derivatives, such as salts of oxalic acid, for example sodium oxalate Na2C2O4, or dimethyl oxalate ((CH3)2C2O4). (wikipedia.org)
  • dubious - discuss] The highly insoluble iron(II) oxalate appears to play a major role in gout, in the nucleation and growth of the otherwise extremely soluble sodium urate. (wikipedia.org)
  • specifically
  • Perhaps the key difficulty in understanding pathogenesis of primary hyperoxaluria, or more specifically, why AGXT ends up in mitochondria instead of peroxisomes, stems from AGXT's somewhat peculiar evolution. (wikipedia.org)
  • results
  • Our data suggest that targeting LDHA results in thorough suppression of oxalate production," commented Bob D. Brown, Ph.D., chief scientific officer and senior vice president at Dicerna. (tmcnet.com)
  • findings
  • At the 12th International Workshop, Dicerna presented research findings on LDHA inhibition, which was shown in animal models to reduce oxalate to normal or near-normal levels in PH types 1, 2, and ethylene glycol-induced PH. (tmcnet.com)