• In the liver, uridine diphosphate (UDP)-glucuronyl transferase (UGT) converts bilirubin to a mixture of monoglucuronides and diglucuronides, referred to as conjugated bilirubin, which is then secreted into the bile canaliculi by an adenosine triphosphate (ATP)-dependent transporter. (medscape.com)
  • Revisiting the Latency of Uridine Diphosphate-Glucuronosyltransferases (UGTs)-How Does the Endoplasmic Reticulum Membrane Influence Their Function? (mdpi.com)
  • Uridine diphosphate-glucuronosyltransferases (UGTs) are phase 2 conjugation enzymes mainly located in the endoplasmic reticulum (ER) of the liver and many other tissues, and can be recovered in artificial ER membrane preparations (microsomes). (mdpi.com)
  • For instance, when UDP picks up a glucose molecule, it becomes converted into UDPG (Uridine Diphosphate Glucose). (biologydiscussion.com)
  • As for the nitrogenous base (or nucleobase) component, the common bases are adenine (A), guanine (G), cytosine (C), and uracil (U). Depending on the number of phosphates that make up the compound, the ribonucleotide may be designated as monophosphate (having only one phosphate group), diphosphate (having two phosphate groups), and triphosphate (having three phosphate groups). (biologyonline.com)
  • Eventually, uridine diphosphate (UDP) and uridine triphosphate (UTP) are produced down the biosynthetic pathway by kinases and dephosphorylation of ATPs. (biologyonline.com)
  • If a second or third phosphate is added to the nucleoside, a nucleoside diphosphate (for example, adenosine diphosphate [ADP] or triphosphate (for example, adenosine triphosphate [ATP]) results (Figure 22.4). (pharmacy180.com)
  • Nucleoside diphosphate kinases ( EC 2.7.4.6 ) (NDK) are enzymes required for the synthesis of nucleoside triphosphates (NTP) other than ATP. (embl.de)
  • Nucleoside diphosphate kinase (Ndk) is an important enzyme that generates nucleoside triphosphates (NTPs) or their deoxy derivatives by terminal phosphotransfer from an NTP such as ATP or GTP to any nucleoside diphosphate or its deoxy derivative. (embl.de)
  • These oligomeric proteins exhibit nucleoside diphosphate kinase (NDPK) activity that catalyzes nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. (embl.de)
  • It absolutely was demonstrated that the particular maintenance idea model pertaining to nucleoside triphosphates (NTPs) about ion-pair reversed-phase HPLC originated by a remarkably exact Kawabe's product which supports the introduction of powerful HPLC methods. (hsdpathway.com)
  • Outline the sequence of reactions that convert inosine monophosphate (IMP), first to AMP and GMP, and subsequently to their corresponding nucleoside triphosphates. (euroasfalti.net)
  • These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. (embl.de)
  • Pyrimidine nucleotides stimulated fMet-Leu-Phe-induced O2- formation in the effectiveness order uridine 5'-O-[3-thio]triphosphate (UTP[gamma S]) = UTP greater than CTP. (uni-regensburg.de)
  • ATP.E. Disorders of Purine and Pyrimidine Metabolism Rebecca S. Wappner PURINE AND PYRIMIDINE METABOLISM Purine and pyrimidine nucleotides are important constituents of RNA, DNA, nucleotide sugars, and other high-energy compounds and of cofactors such as adenosine triphosphate and nicotinamide-adenine dinucleotide. (euroasfalti.net)
  • Since then, receptor subtypes for adenosine-selective (P1 receptors) and purine and pyrimidine selective (P2 receptors) have been cloned and characterized. (euroasfalti.net)
  • As NTPs and it is types are usually utilized for Messenger Laboratory Services ribonucleic acid solution (mRNA) vaccine generation, adenosine-5′-triphosphate (ATP), guanosine-5′-triphosphate (GTP), cytidine-5′-triphosphate (CTP), 5-methylcytidine-5′-triphosphate (m5-CTP), uridine-5′-triphosphate (UTP), 5-methyluridine-5′-triphosphate (m5-UTP), pseudouridine-5′-triphosphate (Ψ-UTP) as well as N1-methylpseudouridine-5′-triphosphate (m1Ψ-UTP) were applied for conjecture product improvement. (hsdpathway.com)
  • AMP, GMP, and IMP shift PRPP amido transferase from a small form to a large form.B. Human diseases that involve abnormalities in purine metabolism include gout, Lesch-Nyhan syndrome, adenosine deaminase deficiency, and purine nucleoside phosphorylase deficiency. (euroasfalti.net)
  • conversion of exogenous uridine to UMP by uridine phosphotransferase.B. Which of the following is a purine base? (euroasfalti.net)
  • Introduction Adenosine Triphosphate (ATP) is a vital molecule in living organisms, serving as a universal energy currency within cells. (rcd.bio)
  • However, no differences were observed either in the number of terminal deoxynucleotidyltransferase-mediated d-uracil triphosphate-biotin nick end-labeling-positive cells or viable neurons in the cornu ammonis 1 sector or in the neurologic deficit score when comparing surviving transgenic and nontransgenic rats. (asahq.org)
  • [ 10 ] Pseudouridine is a nucleoside isomer of uridine that is used as a building block in mitochondrial RNA. (medscape.com)
  • Elongator is a conserved six subunit protein (Elp1p-Elp6p) complex that is required for the formation of ncm5 and mcm5 side chains at wobble uridines in transfer RNAs (tRNAs). (sharingpaper.com)
  • Cells were stimulated with extracellular nucleotides [adenosine triphosphate (ATP) or uridine triphosphate (UTP)] or with lysophosphatidic acid (LPA), a bioactive lipid that regulates keratinocyte proliferation and differentiation. (ljmu.ac.uk)
  • Metabolite formed during enzymatic hydrolysis of uridine-2',3'-cyclic monophosphate (Cat. (biolog.de)
  • In this letter to biochemist Henry Lardy, Kornberg shared his recent work on the pathway of uridine triphosphate synthesis, part of the early work that led him to nucleotide synthesis, and ultimately to DNA synthesis. (nih.gov)
  • Studies have suggested that the VDR , PPARG , HNF1A , and adenosine 5'-triphosphate-binding cassette ABCC8 (which encodes the sulfonylurea receptor) genes are associated with calcineurin inhibitor-induced diabetes. (medscape.com)
  • It is made up of adenosine and three phosphate groups, and the energy derived from ATP is carried in the phosphates' chemical bonds. (biologydictionary.net)