AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation ScienceHealth Care
UreaseHelicobacter pyloriHelicobacter InfectionsHelicobacterGastritisGastric MucosaHelicobacter hepaticusHelicobacter heilmanniiStomachPeptic UlcerClarithromycinBacterial ProteinsMetronidazoleAmoxicillinDyspepsiaAnti-Ulcer AgentsUreaStomach DiseasesAntigens, BacterialOmeprazoleStomach NeoplasmsNickelCanavaliaBreath TestsPyloric AntrumBismuthGastritis, AtrophicStomach Ulcer2-PyridinylmethylsulfinylbenzimidazolesAntibodies, BacterialAnti-Bacterial AgentsGastroscopyDNA, BacterialMolecular Sequence DataProton Pump InhibitorsHelicobacter mustelaeLansoprazoleDrug Therapy, CombinationPolymerase Chain ReactionBiopsyTinidazoleMetaplasiaProteus mirabilisEndoscopy, GastrointestinalGerbillinaeRanitidineFurazolidoneGenes, BacterialLewis Blood-Group SystemRNA, Ribosomal, 16SPepsinogen ADuodenitisEnterobacter aerogenesCampylobacterCytotoxinsGastric MucinsGastric AcidGastrinsRabeprazoleHydrogen-Ion ConcentrationSequence Analysis, DNAGene Expression Regulation, BacterialLymphoma, B-Cell, Marginal ZoneVirulenceAmmoniaBase SequenceVirulence FactorsTetracyclineAntitrichomonal AgentsImmunoglobulin GDNA, RibosomalFecesPeptic Ulcer HemorrhageSulfoxidesGastric JuicePenicillinsEndoscopy, Digestive SystemAntacidsBacterial AdhesionAmino Acid SequencePepsinogensPhylogenyPepsinogen CAcidsSensitivity and SpecificityOrganometallic CompoundsEnzyme-Linked Immunosorbent AssayNitroreductasesSpecies SpecificityColony Count, MicrobialProteusRNA, BacterialParietal Cells, Gastric
InfectionAnti-Helicobacter pyloriBacteriumBacteriaExamined by urease testGastritisInfectionsObtained helicobacter samplesRapid ureaGastric mucosaHumansAntigenBacterialEnzyme ureaseSpeciesCatalaseAntibodiesUlcersUrea into ammonia2001Peptic ulcerStrainsABSTRACTPathogenProducesMicroaerophilicOvergrowthIsolationGram-negativeUreGRecombinantGastrointestinalUreEEpidemiologyPresenceTestEnzymesEtiologyCharacteristicPatientsClinicalMucusVirulence
Infection27
  • Its helical shape (from which the genus name, helicobacter, derives) is thought to have evolved in order to penetrate the mucoid lining of the stomach and thereby establish infection. (wikipedia.org)
  • The 13C-urea breath test (13C-UBT) is a safe, noninvasive, and accurate test for the detection of Helicobacter pylori (H. pylori) infection in adults. (nih.gov)
  • In the case of blood infection with Helicobacter cinaedi , Araoka et al. (cdc.gov)
  • 6 Our previous studies suggested that Helicobacter infection may play a role in the development of gastritis in cetaceans. (vin.com)
  • 1,10,11 It was hypothesized that Helicobacter infection may play a role in the development of gastric lesions in sea otters ( Enhydra lutris ) and California sea lions ( Zalophus californianus ) based on our previously published observations in cetaceans, as well as clinical and pathologic findings of captive and wild animals by researchers and veterinarians. (vin.com)
  • Helicobacter pylori antigen testing is approved by the US Food and Drug Administration (FDA) for use as a noninvasive diagnostic test for H pylori infection and as a test to determine eradication after treatment. (medscape.com)
  • Rodent models of Helicobacter infection need to be refined to investigate any causal links to ID. (bmj.com)
  • The aim of this study is to examine haematological parameters during the acute phase of Helicobacter infection in mice fed on iron-replete and iron deficient diets. (bmj.com)
  • H felis infection was confirmed by urease test and histology. (bmj.com)
  • Other markers of iron status such as serum iron, TIBC and serum ferritin are needed to explore further the impact of Helicobacter infection. (bmj.com)
  • ABSTRACT In this study, endoscopy patients with and without chronic liver disease (CLD) were examined and tested for Helicobacter pylori infection by detecting the presence of serum and salivary anti-H. pylori antibody. (who.int)
  • A 2010 Government of Canada Safety Data Sheet for H. pylori states that a combination of recombinant urease (rUrease), a parenteral vaccine containing H. pylori antigens (CagA, VacA, NAP), and aluminum hydroxide as an adjuvant may be effective against infection. (nccid.ca)
  • Shahid S. Helicobacter Pylori Infection in Children. (webmedcentral.com)
  • In fact, most stomach and duodenal ulcers of humans stem from infection with Helicobacter bacteria. (vin.com)
  • Currently, this ulcerative infection is treated both with medications reducing stomach acid secretion combined with antibiotics specifically directed against Helicobacter . (vin.com)
  • Most dogs and cats harbor Helicobacter in the stomachs to some extent and do not get sick as a result but in the right circumstances, a Helicobacter infection can complicate other intestinal disease. (vin.com)
  • Does Helicobacter Infection Cause Cancer? (vin.com)
  • In humans, it appears that Helicobacter infection may indeed cause cancer. (vin.com)
  • We know that in people Helicobacter infection represents a 400% risk increase for the development of stomach cancer. (vin.com)
  • Seroprevalence of Helicobacter pylori infection in Polish children and adults depending on socioeconomic status and living conditions. (scienceopen.com)
  • Helicobacter pylori ( H. pylori ) infection is one of the most common bacterial infections, affecting approximately 50% of the global population [ 1 ]. (biomedcentral.com)
  • Besides, in "Sixth National Guidelines for the Treatment of Helicobacter pylori Infection 2022" , experts propose that semi-synthetic tetracycline can be used in eradication treatment instead of tetracycline. (biomedcentral.com)
  • Professor Wong and his team used X-ray crystallography as a molecular microscope to visualise how the helper proteins (UreE, UreF, UreG, and UreH) work together to deliver the toxic nickel ions to the urease, an enzyme essential for the infection of the H. pylori in the acidic human stomach. (edu.hk)
  • Since the survival of H. pylori depends on the production of active urease, Prof. Wong also sees the potential of inhibiting the nickel delivery pathway as a novel strategy to fight the H. pylori infection: "As H. pylori is increasingly resistant to antibiotics, we would like to find a new antibiotics target before the problem of resistance gets out of hand. (edu.hk)
  • Helicobacter pylori ( H. pylori ) infection is the most important risk factor for gastritis and peptic ulcer. (biomedcentral.com)
  • Helicobacter pylori infection occurs worldwide, although its exact incidence rate remains unknown. (biomedcentral.com)
  • Helicobacter pylori infection revealed by endoscopy (nodular gastropathy). (medscape.com)
Anti-Helicobacter pylori4
  • Can vitamin B6 alleviate the adverse reactions of quadruple anti-Helicobacter pylori regimen? (biomedcentral.com)
  • To evaluate whether vitamin B6 can alleviate the adverse reactions caused by the quadruple anti- Helicobacter pylori treatment regimen containing minocycline and metronidazole. (biomedcentral.com)
  • Anti-Helicobacter pylori and antiulcerogenic activity of Aframomum pruinosum seeds on indomethacin-induced gastric ulcer in rats. (ufv.br)
  • Are anti-Helicobacter pylori urease antibodies involved in atherosclerotic diseases? (innspub.net)
Bacterium8
  • Helicobacter pylori, previously known as Campylobacter pylori, is a gram-negative, microaerophilic, spiral (helical) bacterium usually found in the stomach. (wikipedia.org)
  • Helicobacter pylori is a helix-shaped (classified as a curved rod, not spirochaete) Gram-negative bacterium about 3 μm long with a diameter of about 0.5 μm. (wikipedia.org)
  • Helicobacter pylori (H. pylori) is a spiral-shaped bacterium found in the stomach, which (along with acid secretion) damages stomach and duodenal tissue, causing inflammation and peptic ulcers. (luriechildrens.org)
  • Helicobacter pylori , the bacterium that resides in the nearly inhospitable acidic environment that is the human stomach, has only recently begun to be understood. (reachmd.com)
  • Helicobacter pylori ( H. pylori) is a gram-negative, microaerophilic curved or S-shaped bacterium that infects the inner lining of the stomach. (nccid.ca)
  • Helicobacter pylori tests are used to diagnose stomach infections caused by the bacterium, Helicobacter pylori (previously known as Campylobacter pylori), which are associated with gastritis (stomach inflammation), ulcers of the stomach or first part of the small intestine, and, in some cases, cancer. (medicaldevice-network.com)
  • The Helicobacter pylori bacterium is responsible for the majority of cases of stomach cancer, the second leading cause of cancer death worldwide. (pasteur.fr)
  • However, there is one problem for the bacterium which is that urease requires nickel ions to function. (edu.hk)
Bacteria9
  • Bruker Daltonics, Billerica, MA, USA) did not enable identification of the bacteria directly from cultured or subcultured blood samples and did not reveal any relationship with the genus Helicobacter although H. pylori , H. canadensis , H. canis , H. cholecystus , H. cinaedi , H. fenneliae and H. mustelae were represented in the Bruker MS database. (cdc.gov)
  • Because of their shape and the way they move, the bacteria can penetrate the stomach's protective mucous lining where they produce the enzyme urease, which generates substances that neutralize the stomach's acids. (luriechildrens.org)
  • Helicobacter pylori (H. pylori) is a common type of bacteria that infects the lining of the stomach and the first part of the small intestine. (medlineplus.gov)
  • Helicobacter is a genus of spiral bacteria that amazingly is able to survive the severe acidity of the stomach. (vin.com)
  • It is unclear what constitutes a few Helicobacter bacteria sharing the stomach with its host peacefully and numerous Helicobacter organisms disrupting the stomach lining integrity and causing disease. (vin.com)
  • Helicobacter Pylori is a small, spiral-shaped bacteria often seen in the gut. (valenciaray.com)
  • The 14C urea breath test noninvasively detects the presence of the urease-producing bacteria Helicobacter pylori in the stomach. (snmjournals.org)
  • H. pylori (Helicobacter pylori) is a type of bacteria that infects your stomach. (ketteringhealth.org)
  • The bacteria make an enzyme called urease. (ketteringhealth.org)
Examined by urease test1
  • Endoscopy was performed, and biopsy specimens were examined by urease test and histological analysis. (nih.gov)
Gastritis2
Infections4
  • Helicobacter infections have also been confirmed in stranded sea otters by PCR. (vin.com)
  • Les anticorps du jaune d'œuf de poule (IgY), production et utilisation en immunisation passive contre les infections entériques bactériennes : une revue. (ac.be)
  • Ureases as a target for the treatment of gastric and urinary infections. (innspub.net)
  • Helicobacter pylori (Hp) is a gram-negative bacillus responsible for one of the most common infections found in humans worldwide. (medscape.com)
Obtained helicobacter samples1
  • Blaser and others obtained helicobacter samples from patients around the world and sequenced their DNA with fascinating results: modern helicobacter strains can be traced to ancestral ones that flourished thousands of years ago. (reachmd.com)
Rapid urea3
  • H. pylori status was assessed by histology and rapid urease test. (nih.gov)
  • Vasapolli R, Ailloud F, Suerbaum S, Neumann J, Koch N, Macke L, Schirra J, Mayerle J, Malfertheiner P, Schulz C. Intraprocedural gastric juice analysis as compared to rapid urease test for real-time detection of Helicobacter pylori . (wjgnet.com)
  • Two gastric tissue specimens were taken by the Maastricht consensus report [ 8 ] is from the antral region of the stomach of positive culture or both a positive histologic each patient during the endoscopic exami- examination and a positive rapid urease test. (who.int)
Gastric mucosa2
  • Helicobacter pylori colonizes the human gastric mucosa and causes various gastroduodenal diseases , including peptic ulceration and gastric cancer . (bvsalud.org)
  • 2,9 To date, at least two novel Helicobacter species have been identified from the gastric mucosa of stranded harp seals ( Phoca vitulina ) and the feces of California sea lions. (vin.com)
Humans6
  • 3,4 All known helicobacters of humans and animals colonize the gastrointestinal tract. (vin.com)
  • 3,4 In humans, Helicobacter pylori is a significant cause of peptic ulcer disease and gastric tumors. (vin.com)
  • Blaser, a physician and microbiologist, became interested in the relationship between helicobacter and humans. (reachmd.com)
  • This ordination is consistent with the idea that humans have been carrying helicobacter since before the out-of-Africa event, which was 58,000 years ago, he revealed. (reachmd.com)
  • As humans diverged around the world, so did their helicobacter…[and it probably] has been in humans and our ancestors since before we were humans. (reachmd.com)
  • When did Helicobacter first colonise humans? (scienceopen.com)
Antigen3
  • Gastric Helicobacter pylori (HP) polypeptide antigen Test kit e sebelisoa ho bona ka mokhoa o nepahetseng gastric helicobacter pylori specific polypeptide antigen lisampoleng tsa mantle a batho.Bakeng sa tšebeliso ea litsebi feela.Ho ipapisitsoe le mokhoa oa sandwich oa li-antibody tse peli, khithi ena e sebelisa theknoloji ea colloidal gold immunochromatography ro ho lemoha ka potlako antigen e khethehileng ea polypeptide ea helicobacter pylori lisampoleng tsa mantle a motho. (jwfbio.com)
  • Gastric Helicobacter pylori (HP) polypeptide antigen Sephetho se ka fumanoa ka mor'a metsotso e 15. (jwfbio.com)
  • Urease, a potent antigen, induces increased immunoglobulin G and immunoglobulin A production. (medscape.com)
Bacterial6
  • Omeprazole may exert both a bacteriostatic and a bacteriocidal effect on the growth of Helicobacter pylori (NCTC 11637) in vitro by inhibiting bacterial urease activity. (bmj.com)
  • AIMS: To assess the potential antibacterial effect of omeprazole, a benzimidazole proton pump inhibitor, on the growth of Helicobacter pylori in vitro and to evaluate the effect of this compound on bacterial urease activity. (bmj.com)
  • Bacterial urease activity is competitively inhibited by omeprazole in a dose dependent manner. (bmj.com)
  • CONCLUSION: The results suggest that omeprazole exerts both a bacteriocidal and a bacteriostatic effect against H pylori and competitively inhibits bacterial extracellular urease activity. (bmj.com)
  • Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori. (scienceopen.com)
  • Bacterial urease converts urea to ammonium and bicarbonate, neutralizing gastric acid and providing protection in the hostile, highly acidic gastric environment. (medscape.com)
Enzyme urease2
Species6
  • all gastric and enterohepatic Helicobacter species are highly motile owing to flagella. (wikipedia.org)
  • Helicobacter species (NHPH) are searched for, the clinician and microbiologist must be aware that the duration of monitored blood cultures should be extended. (cdc.gov)
  • nov., a novel murine urease-negative Helicobacter species. (vin.com)
  • nov., a urease-positive Helicobacter species of dolphins and whales. (vin.com)
  • Some Helicobacter species are also capable of producing toxins but the role of such toxins in this disease process is not clear. (vin.com)
  • Pets, however, get infected with different Helicobacter species and the same association with cancer in these species has not been made. (vin.com)
Catalase2
Antibodies1
Ulcers1
  • Helicobacter pylori overgrowth in the gastrointestinal tract is a contributor to the formation of gastric ulcers, gastric cancer, and a unique lymphoma involving the gut mucosa (mucosal-associated lymphatic tissue lymphoma). (naturalmedicinejournal.com)
Urea into ammonia2
20011
Peptic ulcer1
Strains5
  • It is possible that without additional stomach disease (such as inflammatory bowel disease ) or other factors (stress, anxiety), Helicobacter causes no trouble, plus there are many strains and types of Helicobacter and not all of them cause harm. (vin.com)
  • Colony hybridisation with this ure probe demonstrated that all the ure -positive strains produced urease. (microbiologyresearch.org)
  • Considering the coincidence between production of urease and possession of trh in V. parahaemolyticus , it was concluded that the presence or absence of the ure gene is completely coincident with that of the trh gene in V. parahaemolyticus strains. (microbiologyresearch.org)
  • Honda S. , Matsumoto S. , Miwatani T. , Honda T. A survey of urease-positive Vibrio parahaemolyticus strains isolated from traveller's diarrhea, sea water and imported frozen sea foods. (microbiologyresearch.org)
  • Huq M. I. , Huber D. , Kibryia G. Isolation of urease producing Vibrio parahaemolyticus strains from cases of gastroenteritis. (microbiologyresearch.org)
ABSTRACT1
  • ABSTRACT The study aimed to develop a rapid and simple method for the primary isolation and de- tection of Helicobacter pylori from dyspeptic patients. (who.int)
Pathogen1
  • Helicobacter pylori ( H. pylori) is an important pathogen of paediatric gastroenterology [1, 2]. (webmedcentral.com)
Produces2
  • It also produces urease, which helps it survive the acidic environment by neutralizing acid and modifying the mucosal viscosity. (medscape.com)
  • H. pylori produces a urease enzyme which neutralizes stomach acids and produces chronic inflammation on the stomach lining. (nccid.ca)
Microaerophilic1
  • Helicobacter pylori is microaerophilic - that is, it requires oxygen, but at lower concentration than in the atmosphere. (wikipedia.org)
Overgrowth1
Isolation2
Gram-negative1
  • Helicobacter pylori ( H. pylori ) is a gram-negative bacillus and one of the most common gastrointestinal pathogens globally [ 1 ]. (biomedcentral.com)
UreG3
  • After GTP hydrolysis, UreG changes its shape and releases its bound nickel ions, activating the urease with the help of UreF/UreH. (edu.hk)
  • In H. pylori , the delivery of nickel ions for urease activation is assisted by four helper proteins, UreE, UreF, UreG and UreH. (edu.hk)
  • Prof. Wong said, "It allows the nickel ions to pass from UreE to UreG, and finally to the urease through protein-protein interactions so that the toxic nickel ions have no chance to escape inside the cells where they can create havoc. (edu.hk)
Recombinant2
  • In recent time, vegetables have also been identified as safe and economic expression system for producing the recombinant proteins including the vaccines against many infectious diseases like hepatitis B, malaria, rotavirus, HIV, Helicobacter pylori , pestedes petits ruminants etc. (scialert.net)
  • Impact of vector-priming on the immunogenicity of a live recombinant Salmonella enterica serovar typhi Ty21a vaccine expressing urease A and B from Helicobacter pylori in human volunteers. (mpg.de)
Gastrointestinal2
  • The non- H. pylori helicobacters: their expanding role in gastrointestinal and systemic diseases. (vin.com)
  • Helicobacter pylor i is a common occupant of the human gastrointestinal tract. (naturalmedicinejournal.com)
UreE3
  • UreE is a urease accessory protein. (embl-heidelberg.de)
  • Significantly, the metal-binding sites in UreE and Atx1 are distinct in location and types of residues despite the relationship between these proteins and the mechanism for UreE activation of urease is proposed to be different from the thiol ligand exchange mechanism used by the copper metallochaperones. (embl-heidelberg.de)
  • Crystal structure of Klebsiella aerogenes UreE, a nickel-bindingmetallochaperone for urease activation. (embl-heidelberg.de)
Epidemiology1
Presence2
  • Urease activity was evaluated in aliquots removed from two hour cultures by monitoring the initial change in absorbency at 560 nm in the presence of 0.02% phenol red. (bmj.com)
  • The presence of urease, the enzyme that creates Helicobacter's protective bicarbonate layer, induces a color change in the solution. (vin.com)
Test3
Enzymes2
Etiology1
Characteristic1
  • The characteristic sheathed flagellar filaments of Helicobacter are composed of two copolymerized flagellins, FlaA and FlaB. (wikipedia.org)
Patients3
  • RÉSUMÉ Dans cette étude, des patients soumis à une endoscopie et souffrant ou non d'une pathologie hépatique chronique (PHC) ont fait l'objet d'un examen et d'une recherche d'infection à Helicobacter pylori par détection de la présence d'anticorps anti-H. pylori dans le sérum et la salive. (who.int)
  • RÉSUMÉ L'objectif de cette étude était de mettre au point une méthode rapide et simple permettant d'isoler et de détecter Helicobacter pylori chez des patients dyspeptiques. (who.int)
  • Des échantillons de muqueuse ont été prélevés grâce à une biopsie antrale sur 136 patients dyspeptiques consécutifs pour lesquels un diagnostic d'ulcère gastro-duodénal avait été établi par endoscopie à l'hôpital général de Bassora (Basra) en Iraq. (who.int)
Clinical1
  • Although V. parahaemolyticus does not generally produce urease, several studies have reported urease-positive V. parahaemolyticus isolates from clinical sources. (microbiologyresearch.org)
Mucus1
  • however, if Helicobacter penetrates deeply enough, it will bind to the mucus secreting cells of the stomach and disrupt their ability to produce normal mucus. (vin.com)
Virulence1