Uptake deoxyglucose. Medical search. Frequent questions

The mylohyoid muscle is often believed to exhibit high physiologic fluoro-deoxy-glucose (FDG) uptake. (uzh.ch)
The accumulation of 2-deoxyglucose-6-phosphate (2DG6P), detected using 31P nuclear magnetic resonance spectroscopy, was used to assess glucose uptake before and during insulin stimulation in the isolated perfused heart. (ox.ac.uk)
The mRNA levels of both the insulin-sensitive glucose transporter (GLUT-4) and the transporter responsible for basal glucose uptake (GLUT-1) were quantified by Northern blot analysis. (ox.ac.uk)
In these hearts, the basal rate of glucose uptake was 3-fold greater and hexokinase activity was 1.6 fold greater than that of the control rat hearts. (ox.ac.uk)
Muscle glucose uptake and signaling were measured ex vivo in fetal ( n = 5-8/group) and juvenile ( n = 8/group) offspring. (diabetesjournals.org)
Maternal WSD reduced insulin-stimulated glucose uptake and impaired insulin signaling at the level of Akt phosphorylation in fetal muscle. (diabetesjournals.org)
In juvenile offspring, insulin-stimulated glucose uptake was similarly reduced by both maternal and postweaning WSD and corresponded to modest reductions in insulin-stimulated Akt phosphorylation relative to controls. (diabetesjournals.org)
Journal Article] Extracellular signal-regulated kinase in the ventromedial hypothalamus mediates leptin-induced glucose uptake in red-type skeletal muscle. (nii.ac.jp)
I - K ) Euglycemic-insulinemic clamps were performed on mice on a HFD, and the GIR ( I ), peripheral Gd ( J ), and skeletal glucose uptake ( K ) were evaluated. (jci.org)
statt 11 mM Glucose waren nun 5 mM Deoxyglucose (DG) und 5 mM Pyruvat zugesetzt. (uni-wuerzburg.de)
To evaluate the role of substrate supply, we studied glucose uptake in hearts of control and MI rats. (uni-wuerzburg.de)
In a second set of experiments, glucose uptake was stimulated by insulin (2mU/ml). (uni-wuerzburg.de)
2 months after MI, cellular glucose uptake of the viable myocardium is unchanged at baseline perfusion and during stimulation with insulin. (uni-wuerzburg.de)
Therefore, it is most likely that cellular glucose uptake is not limiting the heart, causing LV dysfunction and impairment of high energy phosphate metabolism. (uni-wuerzburg.de)
Positron emission tomography (PET), with the glucose analog F-18 fluoro-deoxyglucose (FDG), takes advantage of the enhanced glucose uptake observed in neoplastic cells. (nih.gov)
In animal experiments, blood glucose, the homeostasis model assessment (HOMA)-index assessment, glucose tolerance test, and in vivo glucose uptake were all measured. (hindawi.com)
The improvement of glucose intolerance, HOMA-index, and in vivo glucose uptake is evident in addition to the weight loss effect and attenuation of hepatic steatosis. (hindawi.com)
At 120min, a bolus of 14C-2-deoxyglucose is given to assess tissue-specific glucose uptake. (mmpc.org)
Despite these profound reductions in 5-HT uptake sites no significant alterations were found in glucose utilisation in any area of neocortex examined. (erowid.org)
Positron Emission Tomography with fluro-deoxy-glucose (FDG-PET) also showed a 21.8% reduction in glucose uptake at the tumor site in both subjects on the KD. (healthimpactnews.com)
This was paralleled by an elevated glucose utilization estimated as uptake of 2-deoxyglucose in parametrial, retroperitoneal, and inguinal adipose tissues and the soleus and extensor digitorum longus muscles. (diabetesjournals.org)
Alteration of Glucose Uptake i. (digitalarchives.tw)
In the current studies, we observed that MUC16 knockdown pancreatic cancer cells exhibit reduced glucose uptake and lactate secretion along with reduced migration and invasion potential, which can be restored by supplementing the culture media with lactate, an end product of aerobic glycolysis. (oncotarget.com)
Also transports glucose, xylose, fucose (6-deoxygalactose), 2-deoxygalactose and 2-deoxyglucose) (Henderson and Giddens 1977. (lbl.gov)
FDG is an analog of glucose, and its uptake is proportional to glucose metabolic rates. (msdmanuals.com)
Glucose uptake is inhibited by methyl-α-D-glucoside, methyl-β-D-glucoside, p-nitrophenyl-α-D-glucoside, o-nitrophenyl-β-D-glucoside and salicin, but not by 2-deoxyglucose. (lbl.gov)
18F-deoxy-glucose positron emission tomography combined with computed tomography (18F-FDG PET/CT) is routinely used in the detection of malignant disease based on the property of malignant cells to fuel their growth and replication by increased glucose uptake. (viamedica.pl)
Furthermore, the addition of cholate decreased blood insulin levels and prevented high-fat diet-induced decrease of glucose uptake in epitrochlearis. (elsevierpure.com)
Glucose transport inhibitors blocked both [3H]-2-deoxy-glucose (2dG) uptake and phagocytosis of P. aeruginosa. (aai.org)
The Ghrelin study combines topics in areas such as Adipose tissue, Adipocyte, Glucose uptake, Deoxyglucose and Glucose homeostasis. (research.com)

The accumulation of phosphorylated 2-deoxyglucose (2DGP) was increased in skeletal muscles by 56-102% and in diaphragm by 236% at 3 h after treatment with 100 μg/100 g endotoxin. (psu.edu)
H ) Following another week of recovery, the mice were fasted, and [ 3 H]-2-deoxyglucose ( 3 H-2-DOG) uptake in skeletal muscle was measured. (jci.org)

Physiologic left ventricular myocardial FDG uptake is noted (black arrows). (medscape.com)

Bacteremias can be complicated tion of these) and evocative images on computed by secondary localizations in the joints, bones, soft tis- tomography, 18F-fluoro-deoxyglucose-positron emis- sues, arterial wall, and valves ( 5 , 7 , 8 ). (cdc.gov)
Computed tomography (CT) scanning and magnetic resonance imaging (MRI) have higher sensitivity in detecting pheochromocytomas than nuclear medicine scanning with iodine-131 metaiodobenzylguanidine ( 131 I-MIBG), although 131 I-MIBG uptake is more specific. (medscape.com)
Positron emission tomography (PET) is also an alternative imaging test, with agents such as 18F-deoxyglucose (F-FDG), 18F-dihydroxyphenaline (F-DOPA), and 18F-fluorodopamine (F-FDA) being used in cases of negative 123 I-MIBG when there is a high clinical and laboratory suspicion. (medscape.com)

The effect of the psychomotor stimulant, 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy'), upon integrated cerebral function was measured in rats using the quantitative [14C]deoxyglucose autoradiographic technique. (erowid.org)
Alonso, D. & Nungester, W. J. Comparative study of host resistance of guinea pigs and rats V. The effect of pneumococcal products on glycolysis and oxygen uptake by polymorphonuclear leucocytes. (nature.com)

The transport properties of mutant cells were not totally unresponsive to TPA since hexose transport (2-deoxyglucose uptake) could be stimulated in both cell types. (rupress.org)
The major hexose transporter, Htr1 (mediates the active uptake of hexoses by sugar:H+ symport. (lbl.gov)

Physiologic uptake is noted in the ventricular myocardium (black arrow) and in the breasts (white arrows). (medscape.com)

The sublingual glands yield the highest physiologic FDG uptake in the FOM. (uzh.ch)
There is focal low-grade uptake at the right superior cardiac border, considered to represent physiologic uptake in the right atrium (green arrow). (medscape.com)

We examined whether the detection of preferential FDG uptake with PET permits differentiation between benign and malignant focal pulmonary lesions in patients with suspected primary or recurrent lung cancer. (nih.gov)

Insulin resistance was estimated by measuring 2- deoxyglucose uptake in epitrochlearis muscles incubated in vitro. (elsevierpure.com)

Therefore, accumulation of P-DG mirrors uptake. (uni-wuerzburg.de)

Similarly, studies using the 2-deoxyglucose uptake and c-fos expression techniques have shown that the AP is excited by systemic administration of emetic drugs. (nih.gov)

FDG activity in the lesion was expressed as a calculated standardized uptake ratio. (nih.gov)

Pituitary adenomas can manifest as hypermetabolic foci on 18F-FDG PET/CT imaging with increased tracer uptake even in indolent, clinically silent pituitary adenomas with low mitotic activity. (viamedica.pl)

Decreased GLUT-4 mRNA content and insulin-sensitive deoxyglucose uptake show insulin resistance in the hypertensive rat heart. (ox.ac.uk)

Axial FDG-PET image (at approximately the same level as the axial chest CT in Figure 2) shows no abnormal FDG uptake in the precarinal region (purple arrow). (medscape.com)

Fast, low-angle shoot functional magnetic resonance imaging (fMRI), based on the blood oxygenation level-dependent (BOLD) effect, was combined with optical recording of intrinsic signals (ORIS) and 2-deoxyglucose labeling in gerbil barrel cortex. (jneurosci.org)

Also, pulmonary 18 F-FDG uptake was recently reported to be a predictor of global health score and lung physiology in patients with IPF ( 11 ). (snmjournals.org)

Incidental 18F-2-fluoro-2-deoxyglucose (FDG) uptake in blood vessel walls is sometimes demonstrated during routine oncologic imaging with positron emission tomography/computed tomography (PET/CT). (tokushima-u.ac.jp)
Positron emission tomography/computed tomography (PET/CT) scanning utilises a radioactive form of glucose, called 18-fluoro-2-deoxyglucose (FDG) that accumulates within malignant cells because of their high rate of metabolism. (bmj.com)
3. Incidental abnormal FDG uptake in the prostate on 18-fluoro-2-deoxyglucose positron emission tomography-computed tomography scans. (nih.gov)

Analysis of lipid metabolism: in vivo triglyceride clearance test, triglyceride secretion test, fatty acid uptake of into mouse tissues using [3H]-bromo-palmitate, tissue triglyceride and cholesterol content. (nih.gov)
This article responded to the critique published in: Sacks W., Sacks S., and Fleischer A. (1983) 'A comparison of the cerebral uptake and metabolism of labeled glucose and deoxyglucose in vivo in rats. (nih.gov)
Conversely, overexpression of miR-29 by electroporation of mouse tibialis anterior muscle decreased glucose uptake and glycogen content in vivo, concomitant with decreased abundance of GLUT4. (diabetesjournals.org)
In vivo estimation of regional estimating regional myocardial oxygen con- the oxygen uptake and consumption (Fig. 1). (nih.gov)

Glucose turnover price, glycolytic price, endogenous blood sugar production, tissue-specific blood sugar uptake, and hepatic glycogen synthesis had been all determined as referred to (18-20). (technologybooksindustrialprojectreports.com)
Statistical significance was dependant 53910-25-1 IC50 on using the combined Student's check with the next Rabbit Polyclonal to OR5B12 exceptions: diet, activity, plasma insulin, blood sugar turnover price, glycolytic price, and glucose uptake were analyzed by using the unpaired Student's test. (technologybooksindustrialprojectreports.com)

The dose-response curves for lactate production and DG uptake were similar. (eurekamag.com)

Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane (PubMed:9477959, PubMed:26176916). (nih.gov)

Insulin-stimulated glucose uptake in cumulus cells is mediated through phosphatidylinositol 3-kinase signaling as shown by inhibition of insulin-stimulated glucose uptake and Akt phosphorylation with the specific phosphatidylinositol 3-kinase inhibitor, LY294002. (wustl.edu)
The translocation of GLUT4 to the plasma membrane underlies the ability of insulin to stimulate glucose uptake, an event that involves the activation of protein kinase B, several members of the Rab family of GTP-binding proteins and the phosphorylation of the Rab GTPase-activating protein AS160. (bris.ac.uk)
We propose that Rip11 is an AS160- and Rab-binding protein that coordinates the protein kinase signalling and trafficking machinery required to stimulate glucose uptake in response to insulin. (bris.ac.uk)

D-pinitol may act via a post-receptor pathway of insulin action affecting glucose uptake. (aston.ac.uk)

In CEPT1-deficient muscles, an altered SR phospholipid milieu decreased sarco/endoplasmic reticulum Ca 2+ ATPase-dependent calcium uptake, activating calcium-signaling pathways known to improve insulin sensitivity. (diabetesjournals.org)
In addition, the skeletal muscles, soleus, red and white gastrocnemius, extensor digitorum longus (EDL), and diaphragm all showed increased sensitivity of insulin-stimulated 2DG uptake with training. (jci.org)
Although the sensitivity of PET scans is usually much higher than conventional structural images anatomical information from another modality (CT or MRI) is still needed to properly interpret and localize the radioctracer uptake and the PET images are somewhat limited due to low resolution. (techuniq.com)

Analysis of glucose metabolism: insulin tolerance test, glucose tolerance test, glucose or arginine stimulated insulin secretion tests, glucagon, pyruvate, glutamate challenge tests, [14C]-2-deoxy-glucose uptake into mouse tissues, isolation of mouse islets. (nih.gov)
ISL blocked glucose uptake and suppressed production and secretion of lactic acid, which was accompanied with suppressed mitochondrial oxidative phosphorylation (OXPHOS) and glycolysis but increased ROS accumulation. (bvsalud.org)

Insulin-stimulated glucose uptake is thought to be unique to adipocytes, skeletal and cardiac muscle, and the blastocyst. (wustl.edu)

The association of 18F-deoxyglucose (FDG) uptake of PET with polymorphisms in the glucose transporter gene (SLC2A1) and hypoxia-related genes (HIF1A, VEGFA, APEX1) in non-small cell lung cancer. (nih.gov)
We have analyzed the effect of solute carrier family 2 (facilitated glucose transporter), member 1 polymorphisms on 2-[fluorine-18]-fluoro-2-deoxy-D-glucose-uptake with a combination of polymorphisms of hypoxia-inducible factor 1 alpha, apurinic/apyimidinic endonuclease, and vascular endothelial growth factor A in a hypoxia-related pathway. (nih.gov)

We performedaset of experiments on mouse cumuluscells andoocytes and humancumulus cellsusing the nonmetabolizable glucose analog 2-deoxy-D-glucose to measure basal and insulin-stimulated glucose uptake. (wustl.edu)
5. Incubation of L6 muscle cells with D-pinitol (10 -3 M) increased basal 2DG uptake by 41% after 10 min and by 34% after 4 h. (aston.ac.uk)

siRNA-mediated knockdown of Rip11 inhibits insulin-stimulated uptake of 2-deoxyglucose, and overexpression of Rip11 blocks insulin-stimulated insertion of translocated GLUT4 vesicles into the plasma membrane. (bris.ac.uk)

In primary human skeletal muscle cells, inhibition and overexpression strategies demonstrate that miR-29a and miR-29c regulate glucose uptake and insulin-stimulated glucose metabolism. (diabetesjournals.org)

CONCLUSION: These findings implicated that ISL inhibits GC growth by decreasing GLUT4 mediated glucose uptake and inducing PDHK1/PGC-1α-mediated energy metabolic collapse through depressing protein expression of c-Myc and HIF-1α in GC, suggesting its potential application for GC treatment. (bvsalud.org)

At 120min, a bolus of 14C-2-deoxyglucose is given to assess tissue-specific glucose uptake. (mmpc.org)
To determine tissue-specific blood sugar uptake, 20 Ci of [1-14C]2-deoxyglucose was presented with like a bolus 30 min prior to the 53910-25-1 IC50 end of the analysis (1 Ci = 37 GBq). (technologybooksindustrialprojectreports.com)

Diffuse White Adipose Tissue 18F-FDG Uptake-An Unusual Finding on 18F-FDG PET/CT. (nih.gov)
Our studies identify another tissue that, through a classical insulin-signaling pathway, demonstrates insulin-stimulated glucose uptake. (wustl.edu)
In ET animals, adipose tissue exhibited a significant increase in insulin-mediated 2DG uptake and [14C]glucose incorporation into free fatty acids but there was no difference from control in any parameters measured in lung or liver. (jci.org)

Patchy focal or focal on diffuse fluorodeoxyglucose (FDG) uptake on PET imaging. (aerjournal.com)

We show that insulin-stimulated glucose uptake occurs in both compact and expandedcumul us cells of mice, as well a sinhumancumul us cells. (wustl.edu)

Rather, it might be explained by the metabolic response of the whole body: the decrease in FDG sequestration by the skeletal muscle is as profound as to prolong tracer persistence in the bloodstream and thus its availability for brain uptake. (springeropen.com)
FDG is an analog of glucose, and its uptake is proportional to glucose metabolic rates. (msdmanuals.com)

No focal bowel uptake. (cancer.org)

These findings suggest a potential correlation between FDG uptake with EGFR mutation and serum tumor markers. (biomedcentral.com)

Finally, the systemic adaptation to food deprivation decreases glucose disposal and FDG sequestration in the whole body, protracting tracer persistence in the bloodstream as to preserve or even increase brain FDG uptake indexed by SUV. (springeropen.com)
Nelson, Thomas C., Giovanni Lucignani, Janet Goochee, Alison M. Crane, Louis Sokoloff, and National Institute of Mental Health (U.S.). 'Invalidity of Criticisms of the Deoxyglucose Method Based on Alleged Glucose-6-Phosphatase Activity in Brain. (nih.gov)

Tan MCBLinehan DCHawkins WGSiegel BAStrasberg SM Chemotherapy-induced normalization of FDG uptake by colorectal liver metastases does not usually indicate complete pathologic response. (jamanetwork.com)

Kinetic analysis revealed that the Vmax for DG uptake was increased by IL1 (from 36 to 144 pmol/min/mg of cell protein), whereas the Km was unchanged. (eurekamag.com)

Increased DG uptake was blocked by specific antisera to IL1 and by inhibitors of protein and RNA synthesis but not by indomethacin, and inhibitor of prostaglandin production. (eurekamag.com)

The close connection between neuronal activity and glucose consumption accounts for the clinical value of 18F-fluoro-2-deoxyglucose (FDG) imaging in neurodegenerative disorders. (springeropen.com)

areas of uptake on the PET scan are mapped to the CT scan, and this image depicts the primary lesion in the left floor of mouth with metastatic disease to level II. (medscape.com)
Prior to the PET scan your Dad was given an injection of fluoro-deoxyglucose. (cancer.org)
A functionally fused helical CT scan and 18-fluoro-2-deoxyglucose (FDG) PET scans were employed. (bmj.com)

demonstrate any appreciable FDG uptake. (cancer.org)
Two of the forebrain areas highly active during first courtship (as demonstrated by the 14C-2-deoxyglucose technique), the imprinting locus latral neo/hyperstriatum ventrale (LNH) and the secondary visual area hyper-striatum accessorium/dorsale (HAD), demonstrate enhanced fos expression. (uni-bielefeld.de)

8. ANG II increases 2-deoxyglucose uptake in mouse embryonic stem cells. (nih.gov)

D-pinitol did not increase insulin-stimulated 2DG uptake by L6 cells. (aston.ac.uk)

First courtship and chasing both lead to enhanced uptake of 2-DG in the four imprinting areas, as well as subsequent changes in spine density-an anatomical manifestation of the imprinting process. (uni-bielefeld.de)

DG uptake was enhanced by IL1 in serum-starved cells in the presence of neutralizing anti-platelet-derived growth factor serum. (eurekamag.com)
Both sets of cells displayed blunted insulin-stimulated glucose uptake. (wustl.edu)
Glucose transport was measured in L6 rat muscle cells by 2-deoxyglucose (2DG) uptake. (aston.ac.uk)

T and 2-[fluorine-18]-fluoro-2-deoxy-D-glucose-uptake among 154 patients with non-small-cell lung cancer. (nih.gov)
We investigated the kinetics of responses of model lymphoma and glioblastoma cancer cell lines to 18 F-FDG uptake after drug exposure. (snmjournals.org)
At 1 m, pathways related to disease and function categories of cell viability and uptake of 2-deoxyglucose were activated at both doses compared to control and lipid peroxidation pathway was activated at high dose when compared to control. (cdc.gov)
EGFR mutation-induced cell proliferation causes changes in tumor biology and tumor metabolism, which may reflect tumor marker concentration and 18F-FDG uptake on PET/CT. (biomedcentral.com)
The purpose of this study is to investigate an association between cytologic tumor markers and FDG uptake with EGFR mutation status in non-small cell lung cancer (NSCLC). (biomedcentral.com)

Standardised uptake values (SUV) of more than 2.5 were considered positive. (bmj.com)

Therefore, we conducted this study to prospectively investigate an association between cytologic tumor markers and FDG uptake with EGFR mutation status in NSCLC. (biomedcentral.com)

Therefore, the increased insulin-induced 2DG uptake observed in muscle following training is apparently directed towards glucose oxidation. (jci.org)

Radiologists need to be aware of the diseases which can exhibit FDG uptake in the vessel wall for proper interpretation. (tokushima-u.ac.jp)

FDG uptake in vessel walls can also be seen under some non-physiological conditions such as vasculitis and arteriosclerosis. (tokushima-u.ac.jp)

FDG uptake by itself is not necessarily indicative of cancer. (cancer.org)

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