Most deaths from prostate cancer are due to the progression of localized disease into metastatic, castration-resistant prostate cancer, which is characterized by an increased number of these neuroendocrine-like cells. (frontiersin.org)
Response to androgen receptor signaling inhibitors (ARSI) varies widely in metastatic castration resistant prostate cancer (mCRPC). (cdc.gov)
Surgical3
Unlike surgical castration, where the gonads are removed through an incision in the body, chemical castration does not remove organs, nor is it a form of sterilization. (wikipedia.org)
Warning: This article contains graphic details of chemical and surgical procedures performed on an individual who once identified as transgender. (christianpost.com)
In May 2016, The New York Times reported that a number of countries use chemical castration on sex offenders, often in return for reduced sentences. (wikipedia.org)
Chemical castration therapy reduces an individual's libido which then makes some offenders more responsive to the introduction of psychotherapy. (wikipedia.org)
Some criminologists argue that the appearance of a lower recidivism rate in male sex offenders who take chemical castration treatment than in those who do not can be explained by factors other than biological effects of the medication. (wikipedia.org)
In an Instagram post published last week, the Italian government minister announced his party would soon be tabling a proposed law for the experimentation of chemical castration for sex offenders, insisting there should be "zero tolerance" for those convicted of such offenses. (rmx.news)
Some ideas sound perfectly fine, for example tracking serial offenders after they're released, keeping child molesters away from schoolyards and chemical castration for the worst cases, since it's fairly hard to expand those powers to the rest of us. (balloon-juice.com)
While puberty blockers have a long history of different uses, including the chemical castration of violent sex offenders, they are now most commonly recognized for the off-label treatment of gender dysphoria because of their mechanism to stop the production of estrogen and progesterone. (powerlineblog.com)
Incapacitation - Removing the capacity for offenders to re-offend through long term prison sentences, cutting of hands, chemical castration or the death penalty. (revisesociology.com)
Electronic monitoring of offenders or alteration of criminal tendencies through drugs (e.g., chemical castration) are no longer only the stuff of science fiction novels. (typepad.com)
Hormones2
Claiming to "cure" queerness, it can include everything from shock treatment to exorcism and hormones to psychotropic drugs and instilling a sense of shame. (fiftyshadesofgay.co.in)
Puberty is initiated by a biological clock deep in the brain and involves a cascade of chemical messengers that travel to the gonads to cause them to release hormones that evoke secondary sex characteristics and to prepare for procreation using organs laid down before birth. (quadrant.org.au)
Guided by the theoretical domains framework (TDF), urologists and patients from facilities with the highest and lowest castration rates across the VA will be interviewed to identify key preferences and de-implementation barriers for reducing castration as prostate cancer treatment. (biomedcentral.com)
The investigators will conduct national surveys of urologists to prioritize key barriers identified in Aim 1 for stopping incident castration as localized prostate cancer treatment using a DCE experiment design. (biomedcentral.com)
Although some patients with prostate cancer benefit from ADT in terms of survival and symptom improvement, chemical castration is also commonly performed when there is no high level evidence for use and little to no health benefits to patients raising questions of low value care. (biomedcentral.com)
They found that activating an olfactory receptor called OR51E2 in prostate cancer cells caused the cancer to morph into the more aggressive, 'castration-resistant' form of the disease. (frontiersin.org)
This approach slows down the cancer, but resistance typically develops after a year or two, resulting in castration-resistant prostate cancer. (frontiersin.org)
Androgen1
Some medications that have androgenic hormonal activity often cause increased aggression (an example would be the birth control medication, Cheque Drops, which contains one of these androgen-type chemicals). (dogencyclopedia.net)
Criminals2
Offering criminals the option of chemical castration for a reduction in sentence is an example of compulsory sterilization as it can leave a subject sterile if they are required to continue treatment for more than 3 years. (wikipedia.org)
The medication often used as "puberty blockers" is the same medication used for chemical castration for criminals. (liberty.edu)
Commonly1
Leuprolide acetate is an LHRH agonist that is most commonly used in chemical castration today. (wikipedia.org)
Testosterone3
The first use of chemical castration occurred in 1944, when diethylstilbestrol was used with the purpose of lowering men's testosterone. (wikipedia.org)
The antipsychotic agent benperidol was sometimes used to decrease sexual urges in people who displayed what was thought of as inappropriate sexual behavior, and as likewise given by depot injection, though benperidol does not affect testosterone and is therefore not a castration agent. (wikipedia.org)
Abaffy also found that cancer cells secrete 19 OH-AD, which acts as a critical intermediate in the chemical conversion of testosterone into estrogen, essentially feeding their own progression. (frontiersin.org)
Homosexuality2
Following his conviction for "indecency", Turing was obliged to undergo chemical castration to "cure" his homosexuality. (humanists.international)
Turing, having been convicted of gross indecency due to his homosexuality and condemned to chemical castration, was in effect poisoned by the British government. (brooklynrail.org)
Death penalty2
Chemical castration was often seen as an easier alternative to life imprisonment or the death penalty because it allowed the release of the convicted. (wikipedia.org)
A national angst ensued with divergent voices seeking divergent ends: justice, death penalty, fast track courts, end to patriarchy, chemical castration, and a long list that cannot be spelt out here. (dianuke.org)
Lobotomies1
That induces nausea upon the onset of homoerotic stimuli, chemical castration, and even lobotomies. (sifetbabo.com)
Prison1
For rapists and pedophiles, whether Italian or foreign, prison and chemical castration," he added on X. (rmx.news)
Males1
This drug produces total chemical castration in males, and one dose lasts for a month. (jadephoenix.org)
Varies1
The degree castration has on suppressing aggression varies between animals and the age at which it is done. (dogencyclopedia.net)
Puberty1
In that sense, puberty orientates the child towards the binary function of reproduction and rearing of the species. (quadrant.org.au)
Treatment3
Chemical castration is generally reversible when treatment is discontinued, although permanent effects in body chemistry can sometimes be seen, as in the case of bone density loss increasing with length of use of depot medroxyprogesterone acetate (DMPA). (wikipedia.org)
So there are scientists who argue that it makes no biological sense to assume that any treatment that emulates castration would remove sex drive in men but not in women. (wikipedia.org)
Chemical castration is castration via anaphrodisiac drugs, whether to reduce libido and sexual activity, to treat cancer, or otherwise. (wikipedia.org)
It's not enough to just murder people with chemotherapy or with toxic medications that actually promote liver disease and promote metabolic disorders and promote cancer, and promote osteoporosis and Alzheimer's and dementia and everything else - they also want their drugs to be given to children as chemical castrations," the Health Ranger says. (medicalviolence.com)
Scrutiny1
My attempt is to extract these actions from that location of common sense and present them for public scrutiny. (dianuke.org)
Scientific3
The political left operates in total denial of the irrefutable scientific fact that chemicals can feminize men . (neiltyson.news)
When put together, all these scientific data make absolutely no sense. (ipce.info)
In a major victory against the world's most evil corporation, warehouse giant Costco has decided to pull from its store shelves not just Roundup but all weedkiller and herbicide products that contain Monsanto's deadly glyphosate chemical, which has been shown through independent scientific research to cause cancer. (newstarget.com)
Scientists1
When scientists first described the receptors responsible for our sense of smell , they naturally assumed that these chemical sensors resided exclusively in the lining of our noses. (frontiersin.org)
Shame2
They may feel a sense of shame, fear, or despair towards their existential condition and therefore be driven by a desire (or dream) for change. (sifetbabo.com)
Probably because gay people, once they accept their sexual orientation, may still feel a sense of shame about their condition and consequently choose not to report it publicly. (sifetbabo.com)
Logical2
There is nothing that justifies or makes a bit of logical sense about having boys that have applied the accoutrements of being a girl competing with real girls in sports. (floppingaces.net)
The tragedy of this lies in the fact that such actions of the state have become so recurrent that they have entered our common sense and they present themselves as normal and logical responses. (dianuke.org)
Year1
The League's bill for the experimentation of chemical castration for rapists and pedophiles will soon be under discussion and I hope approved," he said in response to the news that two 13-year-old children had been gang-raped by seven individuals, including six teenagers, in the town of Caivano last month. (rmx.news)
Common2
full development is less common unless chemical castration is combined with feminizing oestrogen therapy. (wikipedia.org)
the opposition to these common-sense provisions reveals this reality. (myfaithvotes.org)
Makes2
In Hale's case, the fact that her body was being bombarded day in and day out with Big Pharma chemicals as part of her transition, it only makes sense that her mind eventually snapped. (medicalviolence.com)
On the first hand it makes perfect sense to keep likely predators out of a social site for kids. (balloon-juice.com)
Sexual3
Matteo Salvini, the leader of Italy's co-governing League party, has renewed his call for the introduction of chemical castration for rapists and pedophiles after a number of high-profile sexual assaults on minors sparked uproar across the country. (rmx.news)
Chemical castration would also be offered to any sexual offender on a voluntary basis who wished to show the court they are willing to change and demonstrate remorse. (rmx.news)
Fosters a false sense of trust and authority over a child in order to desensitize or break down a child's resistance to sexual abuse. (capitolhilltimes.com)
Victims1
As the months go by, these homosexual victims end up feeling a strong sense of anxiety and frustration due to the therapy's inability to bring about the promised changes. (sifetbabo.com)
Make sense2
Although it is unknown at this time if it has been used in pre- operative TS's, estrogens are not contraindicated and it's use may make sense. (jadephoenix.org)
Leftists want power and money, and if you examine their policies with this in mind, they pretty much always make sense. (powerlineblog.com)
Having a good1
Lea and djilly are a lovely couple, very welcoming while also having a good sense of personal space. (taparu.com)
Science1
Although they frequently invoke "science" in an effort to support their politics, liberals hold shocking science contradictions that make no rational sense whatsoever. (neiltyson.news)
Products1
So, while the Pope can say it is right for us to rejoice in advances like biotechnology and chemical industries as 'wonderful products of a God-given human creativity,' he simultaneously asserts that man is lacking an accompanying sound ethic to guide and inform him in his care of creation. (feedstuffs.com)