citation needed] Based on the recommendation of the EACD, the New Zealand government has passed legislation which placed BZP, along with the other piperazine derivatives TFMPP, mCPP, pFPP, MeOPP and MBZP, into Class C of the New Zealand Misuse of Drugs Act 1975. (wikipedia.org)
Two calcium channel blockers available in Europe and South America , which are piperazine derivatives, are thought to cause drug-induced parkinsonism by blocking dopamine receptors. (parkinsonsinfoclub.com)
Psychoactive substances1
Important: Every country has its own unique set of rules, commonly referred to as law, especially when it comes to recreational drugs / synthetic designer drugs / psychotropic substances / New Psychoactive Substances / Drugs / (prescription) medicine, and chemicals in general. (rc-scene.com)
Benzylpiperazine1
The most common piperidines and piperazine are phencyclidine (PCP), ketamine, benzylpiperazine (BZP), and 3-trifluoromethylphenylpiperazine (TFMPP). (medscape.com)
Compound3
Unlike the related piperazine compound meta-chlorophenylpiperazine (mCPP), TFMPP has insignificant affinity for the 5-HT3 receptor (IC50 = 2,373 nM). (wikipedia.org)
Hallucinogens can be classified and grouped by chemical structure and the compound from which they are derived. (medscape.com)
Troparil is a chemical compound that belongs to the class of substances known as phenyltropanes. (researchem.net)
Drugs4
Studies into other related piperazine drugs such as mCPP suggest that certain side effects such as anxiety, headache and nausea are common to all drugs of this class, and pills containing TFMPP are reported by users to produce comparatively more severe hangover effects than those containing only BZP. (wikipedia.org)
Bath salt" is the informal street name given to designer drugs containing substituted or synthetic cathinone chemicals. (medscape.com)
In addition, ligands are being discovered which, as single chemical entities, are able to modulate multiple epigenetic targets simultaneously (multitarget epigenetic drugs). (biomedcentral.com)
Among the advantages of multitarget drugs vs drug combinations are the more predictable pharmacokinetic (PK) and pharmacodynamic (PD) relationship of the components of a single medicine, the possibility that one motif might improve the bioavailability of the second entity, the greater efficacy against advanced-stage diseases, the lower toxicities, the simultaneous presence of the chemical entities in multiple tissues, and the improved patient compliance [ 2 ]. (biomedcentral.com)
Derivative2
Prazosin hydrochloride, USP a quinazoline derivative, is the first of a new chemical class of antihypertensives. (nih.gov)
Cinnarizine is a drug derivative of piperazine, and characterized as an antihistamine and a calcium channel blocker, it is also known to promote cerebral blood flow, and so is used to treat cerebral apoplexy, post-trauma cerebral symptoms, and cerebral arteriosclerosis.However, it is more commonly prescribed for nausea and vomiting due to motion sickness or other sources such as chemotherapy,vertigoor Ménière's disease. (imexoverseas.in)
Potentials1
The aim of this study, therefore, was to perform an electrophilic reaction chemistry analysis to explain the differing respiratory sensitizing potentials of 16 chemicals containing both single and multiple functional groups. (cdc.gov)
Structural2
The focus of these studies enable the identification of the respiratory sensitization potential has been to attempt to identify the structural features of the of such chemicals for regulatory purposes ( 3 ). (cdc.gov)
Nevertheless, irrespective of the PAR identified, the challenge is the same: to pharmacologically mimic a peptide ligand which, unlike classical peptide receptors such as neurokinin (NK) or angiotensin type receptors which have soluble cognate ligands, remains tethered to the receptor and thus require a unique set of structural constraints to interact with the receptor optimally. (silverchair.com)
Molecular3
The finding of heterocyclic alkanes with destructive quantum interference charts a pathway for chemical design of short molecular insulators using organic molecules. (rsc.org)
Certain types of low molecular weight chemicals have the ability to cause respiratory sensitization via haptenation of carrier proteins. (cdc.gov)
Sensitizer-induced occupational asthma is an immunologic form of asthma which occurs due to inhalation of specific substances (i.e., high-molecular-weight proteins from plants and animal origins, or low-molecular-weight agents that include chemicals, metals and wood dusts) and occurs after a latency period of several weeks to years. (mdwiki.org)
Emit1
The more these chemicals you emit the more they get invited to you, fat and larger individuals are known to emit more carbon dioxide than small stature individuals. (informationparlour.com)
Substances1
Children are more at risk with this chemical due because their skin easily absorbs substances from the environment, chemicals also affect their developing nervous system. (informationparlour.com)
Potency1
The modern drug discovery process has largely focused its attention in the so-called magic bullets, single chemical entities that exhibit high selectivity and potency for a particular target. (biomedcentral.com)
Quantum2
Unlike previously explored non-methylated alkanes and methylthiomethyl-functionalized cyclohexanes, we find that these heterocyclic alkanes show significant suppression of conductance due to destructive quantum interference in the σ-system. (rsc.org)
The analysis has been supported by quantum chemical calculations probing the electrophilicities of the reactive chemicals. (cdc.gov)
Single2
The interaction of itraconazole with the active 1-(2- pyrimidinyl)-piperazine metabolite of buspirone has been studied after a single oral dose of buspirone 10 mg (27). (banglaforexacademy.com)
In this article, we examine the single-molecule junction properties of saturated heterocyclic cyclohexane derivates, 1,4- dithiane , 1,4- piperazine and 1,4-diazabicyclo[2.2.2]octane, C222-diaza , also known as DABCO, shown in Scheme 1 . (rsc.org)
Drug1
3-Trifluoromethylphenylpiperazine (TFMPP) is a recreational drug of the phenylpiperazine chemical class and is a substituted piperazine. (wikipedia.org)
Body2
Researchers don't know exactly how hydroxyzine works in the human body and mind to treat anxiety, but most healthcare providers agree that it affects 2 chemicals in our bodies. (borreliosidilyme.it)
Diphenhydramine is an antihistamine that reduces the effects of natural chemical histamine in the body. (imexoverseas.in)
Traditional2
Unlike traditional LCD displays, this eliminates the need for a backlight. (chemenu.com)
Unlike traditional photovoltaic cells, which are typically made of inorganic semiconductors like silicon, OPV uses organic molecules or polymers as the active material. (chemenu.com)
Common1
WEA is present in about a fifth of patients with asthma and a wide variety of conditions at work, including irritant chemicals, dusts, second-hand smoke, common allergens that may be present at work, as well as other "exposures" such as emotional stress, worksite temperature, and physical exertion can exacerbate asthma symptoms in these patients. (mdwiki.org)
Health2
Despite the risk to human health, no well- to allow the identification of LMW chemicals capable of causing validated or widely accepted test method currently exists to respiratory sensitization ( 2, 3, 8, 9 ). (cdc.gov)
NPS / Research Chemicals always bear an immense risk to your health and have caused thousands of tragedies and even fatalities in recent years. (rc-scene.com)
Duration1
One noteworthy distinction of troparil is its extended duration of action, which is attributed to its unique chemical structure. (researchem.net)
Work2
Chlordiazepoxide was synthesised from work on a chemical dye, quinazolone-3-oxides. (wikidoc.org)
Unlike those with sensitizer-induced occupational asthma, subjects with irritant-induced occupational asthma do not develop work-related asthma symptoms after re-exposure to low concentrations of the irritant that initiated the symptoms. (mdwiki.org)
Categories2
cellular mechanisms, in the cytokine and chemokine profiles, For instance, binding studies between cysteine, lysine, and and in the profiles of the types of T-cells involved ( 10 ), an dinitrochlorobenzene (DNCB) and trimellitic anhydride (TMA) understanding of the electrophilic reaction chemistry allows for indicate that a difference in the ability to bind to either cellular the formation of mechanistic chemical categories. (cdc.gov)
Given that it has been has been shown that DNCB, which causes skin sensitization suggested that detailed mechanistic knowledge is required if but not respiratory sensitization, binds preferentially to the model chemical categories are going to be useful in regulatory nucleophile N-acetyl cysteine. (cdc.gov)
Previous1
Unlike previous short-term analyses, we found that the acidosis-mediated autophagy occurred mainly as an early stress response but not for later adaptation to microenvironmental acidification. (biomedcentral.com)
Features1
Unlike cocaine, the trail features a non-hydrolyzable carbon-carbon bond directly connecting the phenyl ring to the tropane ring. (researchem.net)
Properties1
As a preservative for ophthalmic solutions, we evaluated the physical and chemical properties (absorption to a sterile filter, solubility, heat stress stability, and light/UV stress stability), and also the anti-microbial activity. (bvsalud.org)
Skin2
If a substance or chemical has the ability to melt plastics and nylon, it would not be wise to rub such a chemical on your skin, DEET has the capability to do exactly just that. (informationparlour.com)
This is due or soluble proteins could be responsible for the differing skin to the covalent binding to a protein being the essential step that and respiratory-sensitizing abilities of the two chemicals ( 7 ). (cdc.gov)
Description1
The labs paladins auto aim knowledge regarding the concepts, use of warzone noclip speed and chemicals, carrying out instruction manually in practical demonstrations, description of observation made while performing the practical, presentation skills, star wars battlefront 2 exploits preparation, specimens viewing warzone cheat codes and so and so forth. (prowissen-lauf.de)
Action1
Unlike conventional alpha-blockers, the antihypertensive action of prazosin is usually not accompanied by a reflex tachycardia. (nih.gov)
Produce1
Also, some people seem to produce more of this kind of chemicals than others, which is why some people may seem to have more mosquito bite than others. (informationparlour.com)