• joints
  • Efficacy and safety of collagenase Clostridium Histolyticum in the treatment of proximal interphalangeal joints in Dupuytren contracture: Combined analysis of 4 phase 3 clinical trials. (doctors-hospital.net)
  • The contractures in the joints can result in delayed walking development in the first 5 years, but severity of contractures do not necessarily predict eventual walking ability or inability. (wikipedia.org)
  • The types of outwardly visible conditions involve facies not matching other known disorders, contracture of the joints, and skin lesions appearing across any part of the body. (wikipedia.org)
  • occurs
  • Research from PE Arkkila et al concluded that people with both type 1 and type 2 diabetes can be affected - but Dupruyten's contracture occurs at a younger age in those with type 1. (diabetes.co.uk)
  • genetic
  • Dupuytren's contracture , also known as palmar fibromatosis, is a common genetic condition that mostly affects older adult Caucasian males, although anyone can develop it. (healthery.com)
  • In terms of prevention, the genetic factors that contribute to the development of Dupuytren's Contracture cannot really be mitigated. (healthery.com)
  • Though the pathomechanism of Marden-Walker syndrome is unknown, it may be caused by a genetic defect which manifests as a dysfunctional molecular mechanism in the primary cilia structures of the cell. (wikipedia.org)
  • secondary
  • The function of the secondary ubiquitin remains largely unknown, however it is believed that it may facilitate conformational changes seen in the E1 enzyme during the transthioesterification process. (wikipedia.org)