The ovaries consist of different types of tissue ( epithelial , germ cells, and sex cord tissue), which may give rise to benign or malignant tumors . (amboss.com)
Malignant tumors may occur and are usually sporadic (with one report of a malignant tumor associated with Carney syndrome ). (medscape.com)
Necrosis can be seen in malignant tumors. (medscape.com)
Malignant tumors are larger and may have areas of necrosis. (medscape.com)
Also, this disease is characterized by a high risk of developing gastrointestinal and extra-intestinal tumors, including benign or malignant tumors of the reproductive system.One of the first signs of the disease in male patients may be prepubertal gynecomastia associated with large-cell calcifying Sertoli cells tumors expressing aromatase. (bvsalud.org)
Epithelial ovarian4
Epithelial ovarian tumors are the most common tumor subtype. (amboss.com)
The most common histology-high-grade serous epithelial ovarian cancer-is considered as a single clinical entity along with fallopian tube and peritoneal cancers because of shared clinical features. (merckmanuals.com)
The most common histology-high-grade serous epithelial ovarian cancer-is considered as a single clinical entity along. (merckmanuals.com)
Primary lesions include epithelial ovarian carcinoma (70% of all ovarian malignancies). (medscape.com)
Primitive gonadal stroma1
Sertoli-Leydig cell tumour is a group of tumors composed of variable proportions of Sertoli cells, Leydig cells, and in the case of intermediate and poorly differentiated neoplasms, primitive gonadal stroma and sometimes heterologous elements. (wikipedia.org)
Sertoli19
Sertoli-Leydig cell tumour (a sex-cord stromal tumor), is a testosterone-secreting ovarian tumor and is a member of the sex cord-stromal tumour group of ovarian and testicular cancers. (wikipedia.org)
Both terms are classified under Sertoli-Leydig cell tumour in MeSH. (wikipedia.org)
The exact cause of Sertoli-Leydig cell tumour is not known. (wikipedia.org)
Presence of an ovarian tumour plus hormonal disturbances suggests a Sertoli-Leydig cell tumour. (wikipedia.org)
Because in many cases Sertoli-Leydig cell tumour does not produce elevated tumour markers, the focus of surveillance is on repeated physical examination and imaging. (wikipedia.org)
Sertoli-Leydig cell tumor: A rare ovarian neoplasm. (wikipedia.org)
Testicular sex cord stromal tumors include Leydig cell tumors, Sertoli cell tumors, and granulosa cell tumors. (medscape.com)
A typical Sertoli cell tumor (see the images below) is a tumor derived from Sertoli cells, located within seminiferous tubules, which help support spermatogenesis. (medscape.com)
Sertoli cell tumors account for less than 1% of testicular tumors, and they occur both in children (15% of cases) and in middle-aged adults and can be malignant (about 10% of cases) in both. (medscape.com)
Patients with Sertoli cell sex cord stromal tumors present with a testicular mass, and estrogen production by the tumor can result in gynecomastia and impotence . (medscape.com)
In sclerosing Sertoli cell tumor, patients present with a testicular mass and without endocrinologic symptoms. (medscape.com)
In large-cell calcifying Sertoli cell tumor, patients are young, with age at diagnosis ranging from 16-37 years. (medscape.com)
Characterized byvtche presence of tumor necrosis, cytologic atypia and mitotic activity. (brainscape.com)
Leydig13
High magnification micrograph of a Leydig cell tumour. (wikipedia.org)
Leydig cell tumors (see the image below) are derived from normal Leydig cells that produce testosterone and are located in the interstitium of the testis. (medscape.com)
In boys, Leydig cell tumors are benign. (medscape.com)
Leydig cell tumors (see the image below) are rare testicular tumors of the male gonadal interstitium that may be hormonally active and lead to feminizing or virilizing syndromes. (medscape.com)
Leydig cell tumors may be an incidental finding of a testicular mass on scrotal ultrasonography performed for other conditions. (medscape.com)
Radical orchiectomy was once the primary treatment for Leydig cell tumors, and it remains in use for malignant cases. (medscape.com)
When Leydig cell tumors are diagnosed and treated early, testicle-sparing surgery has proved to be a feasible and safe choice and could be regarded as first-line therapy. (medscape.com)
In a study of 20 patients with Leydig cell tumors who were treated with conservative surgery, follow-up for a mean of 15 years found 100% disease-free survival, with no local recurrences or metastases. (medscape.com)
Leydig cell tumors are rare testicular tumors of the male gonadal interstitium. (medscape.com)
Leydig cell tumors are usually benign, but malignant variants also occur. (medscape.com)
Leydig cell tumors were once managed primarily with radical orchiectomy . (medscape.com)
The etiology of Leydig cell tumors remains unknown. (medscape.com)
Ovary2
Adult-type granulosa cell tumors of the testicle are much less common than in the adult female ovary. (medscape.com)
Malignant ovarian lesions include primary lesions arising from normal structures within the ovary and secondary lesions from cancers arising elsewhere in the body. (medscape.com)
Syndromes3
Estrogen excess and feminizing syndromes may occur from the peripheral aromatization of testosterone or from the direct production of estradiol by the tumor itself. (medscape.com)
Paraneoplastic syndromes due to tumor-mediated factors lead to various presentations. (medscape.com)
Peutz-Jeghers Syndrome (Peutz-Jeghers Syndrome, PJS) refers to syndromes of hereditary tumor predisposition and is caused by pathological variants of the STK11 gene, leading to a defect in the synthesis of serine/threonine kinase 11 protein, which acts as a tumor suppressor.Clinical symptoms of the syndrome are combination of hamartomatous polyposis of the gastrointestinal tract and specific skin-mucosal hyperpigmentation. (bvsalud.org)
Cancers1
Colorectal cancer is unique among human tumors since almost all cancers derive from macroscopically visible benign polypoid precursors. (bvsalud.org)
Gynecologic3
In the United States, ovarian cancer is the second most common gynecologic cancer (affecting approximately 1/70 women). (merckmanuals.com)
Ovarian cancer is the most common cause of cancer death from gynecologic tumors in the United States. (medscape.com)
In the US, ovarian cancer is the 2nd most common gynecologic cancer (affecting about 1/70 women). (msdmanuals.com)
Arrhenoblastoma1
Ovarian tumors include luteoma of pregnancy, arrhenoblastoma, hilar-cell tumor, masculinizing ovarian stromal cell tumor, and Krukenberg tumor. (health.am)
Granulosa1
In patients with granulosa cell tumor, the average age is 42 years, and 20% of male patients present with gynecomastia. (medscape.com)
Solitary tumors of the uterus which arise de novo from the mesenchymal cells of the myometrium. (brainscape.com)
Symptoms2
Early ovarian cancer causes minimal, nonspecific, or no symptoms. (medscape.com)
Symptoms independently associated with the presence of ovarian cancer include pelvic and abdominal pain, increased abdominal size and bloating, and difficulty eating or feeling full. (medscape.com)
Histology1
citation needed] For malignant tumours with undifferentiated histology, prognosis is poor. (wikipedia.org)
Solitary1
Solitary or multiple benign hepatic vascular tumors, usually occurring in women of 20-50 years of age. (lookformedical.com)
Hereditary1
These hereditary cases tend to be younger, often have a multinodular thyroid goiter and there may be a personal or family history of other rare tumors such as pleuropulmonary blastoma, Wilms tumor and cervical rhabdomyosarcoma. (wikipedia.org)
Serum1
The US Preventive Services Task Force (USPSTF) recommends against screening (with serum CA125 level or transvaginal ultrasonography) for ovarian cancer in the general population. (medscape.com)
Ovaries1
The presence of advanced ovarian cancer is often suspected on clinical grounds, but it can be confirmed only pathologically by removal of the ovaries or, when the disease is advanced, by sampling tissue or ascitic fluid. (medscape.com)
Testosterone2
Due to excess testosterone secreted by the tumour, one-third of adult females present with a recent history of progressive masculinization. (wikipedia.org)
Although these tumors usually secrete testosterone, the production of estrogen, progesterone, and corticosteroids has also been described. (medscape.com)
Subtypes1
The tumour is subdivided into many different subtypes. (wikipedia.org)
Cysts1
Tumors of the juvenile type are small and solid and contain multiple small cysts. (medscape.com)
Ascites1
Patients with more advanced disease may present with ovarian or pelvic mass, ascites, pleural effusion, or abdominal mass or bowel obstruction. (medscape.com)
Diagnosis2
Fine-needle aspiration (FNA) or percutaneous biopsy of an adnexal mass is not routinely recommended, as it may delay diagnosis and treatment of ovarian cancer. (medscape.com)
Instead, if a clinical suggestion of ovarian cancer is present, the patient should undergo laparoscopic evaluation or laparotomy, based on the presentation, for diagnosis and staging. (medscape.com)
Rare4
The tumour occurs in early adulthood (not seen in newborn), is rare, comprising less than 1% of testicular tumours. (wikipedia.org)
The juvenile type of this condition is a rare sex cord stromal tumor that occurs in males in the first few months of life. (medscape.com)
Tumors are unilateral, with rare exceptions. (medscape.com)
Untreated maternal virilizing CAH is another potential cause, though androgen-secreting adrenal tumor in the mother is rare. (health.am)
Tissue1
An increase in the number of cells in a tissue or organ without tumor formation. (lookformedical.com)
Occurs2
While the tumour can occur at any age, it occurs most often in young adults. (wikipedia.org)
The tumor occurs both as a part of the Carney complex and in patients with Peutz-Jeghers syndrome . (medscape.com)
Markers1
Evaluation usually includes ultrasonography, CT or MRI, and measurement of tumor markers (eg, cancer antigen 125). (merckmanuals.com)
Adults1
Adults with androgen-secreting tumors are generally asymptomatic. (medscape.com)
Patients1
Routine imaging is not required in all patients in whom ovarian cancer is highly suggested. (medscape.com)