Uncontrolled viral respiratory syndrome coronavirus global severe acute respiratory syndrome. Medical search. Frequent questions

Critically ill patients can develop a severe inflammatory lung condition called acute respiratory distress syndrome (ARDS), which affects their ability to breathe unaided. (medicalnewstoday.com)
Clinical data indicate that severe COVID-19 most commonly manifests as viral pneumonia-induced acute respiratory distress syndrome (ARDS), a clinical entity mechanistically understood best in the context of influenza A virus-induced pneumonia. (ersjournals.com)
Our review explores influenza A virus-induced acute respiratory distress syndrome (ARDS) as a paradigm for understanding coronavirus disease 2019 (COVID-19)-induced ARDS pathogenesis and ageing as a risk factor for severe disease. (ersjournals.com)
Thankfully, most patients experience mild symptoms and recover on their own, but certain patients-particularly the elderly and those with comorbidities-progress on to severe symptoms such as acute respiratory distress syndrome (ARDS). (polytrendy.com)
Acute respiratory distress syndrome (ARDS) is a life-threatening medical condition mainly known by widespread and uncontrolled inflammation it causes in the lungs, which in turn is associated with the loss of surfactant and impaired pulmonary capillary endothelium, resulting in fluid accumulation in the distal airspaces. (justia.com)
Severe and critical cases are not only associated with pneumonia and acute respiratory distress syndrome but also metabolic acidosis, acute kidney injury and acute cardiac injury. (anesthesiaexperts.com)
Separate research conducted at the Karolinska Hospital, based on autopsies of individuals who have died from COVID-19, has demonstrated that a significant number showed evidence of Acute Respiratory Distress Syndrome (ARDS), which is the cause of death for 70 percent of such patients, resulting from cytokine storm. (wsws.org)
About 42.3% of COVID-19 mortalities were diabetic patients, death rates were significantly higher in hospitalized type 2 diabetic patients than non-diabetic ones and were more susceptible to acute respiratory distress syndrome and other life threatening complications. (actascientific.com)
COVID-19 may rapidly develop into acute respiratory distress syndrome (ARDS) and in some cases, lead to multiple organ dysfunction or death. (newvita.com)

In this uncontrolled, exploratory study, 77 adults hospitalized with confirmed COVID-19 were treated with either nebulized IFN-α2b (5 mU b.i.d.), arbidol (200 mg t.i.d.) or a combination of IFN-α2b plus arbidol. (frontiersin.org)
The World Health Organization (WHO) confirmed COVID-19 as a global pandemic on March 11, 2020. (springeropen.com)
The CHMP based its positive opinion on the scientific evidence supporting PAXLOVID, including data from the Phase 2/3 EPIC-HR ( E valuation of P rotease I nhibition for C OVID-19 in H igh- R isk Patients) trial, which enrolled non-hospitalized adults aged 18 and older with confirmed COVID-19 who are at increased risk of progressing to severe illness. (starkvilledailynews.com)

The infections identified included: ARI, avian influenza A(H5N1), influenza A(H1N1)pdm09 and Middle East respiratory syndrome coronavirus (MERS-CoV) infection. (who.int)
The global pandemic of COVID-19 cases caused by infection with SARS-CoV-2 is ongoing, with no approved antiviral intervention. (frontiersin.org)
In December 2019, an outbreak of pneumonia was reported in Wuhan, Hubei province, China, resulting from infection with a novel coronavirus (CoV), severe acute respiratory syndrome (SARS)-CoV-2. (frontiersin.org)
Type I IFNs-α/β are broad spectrum antivirals, exhibiting both direct inhibitory effects on viral replication and supporting an immune response to clear virus infection ( 2 ). (frontiersin.org)
Due to their distinct ecology/behaviour, bats are naturally more susceptible to viral infection and transmission. (wikipedia.org)
Spread through droplet, it gains entry to body cells through ACE2 cell receptors, causing viral infection-related inflammation, and predominantly infects the lower respiratory tract. (nutrition-evidence.com)
Notably, there are several significant risk factors for severe COVID-19 infection. (nutrition-evidence.com)
Furthermore, nutritional status and the role of diet and lifestyle is considered, as it is known to affect patient outcomes in other severe infections and may play a role in COVID-19 infection. (nutrition-evidence.com)
In literature, this entity is known by different names: post-acute COVID-19 sequelae, post-COVID syndrome, post-COVID condition, long COVID, COVID long-haulers, post-acute sequelae of SARS-CoV-2 infection, etc. (springer.com)
Most studies defined PCS as the persistence of acute symptoms or the development of new symptoms beyond 4 wk after an acute COVID-19 infection [ 5 ]. (springer.com)
An electronic search was conducted in Scopus, PubMed and medRxiv using the keywords ["Siemens AND CoV2Ag"] OR ["Siemens AND SARS-CoV-2 AND antigen"] for capturing studies that investigated the accuracy of Siemens CoV2Ag for diagnosing acute SARS-CoV-2 infection against a reference SARS-CoV-2 molecular test. (degruyter.com)
The current WHO recommendations still emphasize the concept that the diagnosis of acute SARS-CoV-2 infection shall be based on identification of unique SARS-CoV-2 sequences (e.g., viral-specific RNA) by means of nucleic acid amplification tests (NAATs), including real-time reverse-transcription polymerase chain reaction (RT-PCR), specifically developed for targeting sequences within the E , RdRP , N and S viral genes [ 9 ]. (degruyter.com)
Improved Zn status may also reduce the risk of bacterial co‑infection by improving mucociliary clearance and barrier function of the respiratory epithelium, as well as direct antibacterial effects against S. pneumoniae. (spandidos-publications.com)
Moreover, we discuss the deleterious effect of interferon-γ activity in influenza infection and how this observation contrasts with findings in severe COVID-19. (ersjournals.com)
Furthermore, the body's over-exuberant immune response to either SARS-CoV-2 or the secondary infection can result in what is known as a cytokine storm, where the overproduction of immune regulators called cytokines results in uncontrolled inflammation, inflicting damage that leads to organ failure and ultimately death. (polytrendy.com)
However, evidence of the disease burden and factors associated with severe COVID-19 infection among HCWs is limited. (biomedcentral.com)
Therefore, this article aims to describe the prevalence of severe COVID-19 disease among HCWs in Sabah, Malaysia, and to determine the factors associated with severe COVID-19 infection. (biomedcentral.com)
HCWs should strictly adhere to preventive measures, including vaccination, personal protective equipment, and early referral to a physician upon identifying severe COVID-19 infection. (biomedcentral.com)
A cohort study in the United Kingdom (UK) found that the essential workers, including HCWs, the risk of acquiring severe COVID-19 infection seven times greater compared to the non-essential workers (RR 7.43, 95% CI 5.52 to 10.00) [ 9 ]. (biomedcentral.com)
With coronavirus confirmed in the UK, do masks help ward off infection? (yahoo.com)
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, is an ongoing global pandemic. (molcells.org)
Therefore, current treatments focus on managing the inflammation caused by SARS-CoV-2 infection, while vaccines and anti-viral agents are developed. (molcells.org)
Many disorders can decrease the number of lymphocytes in the blood, but viral infections (including HIV infection) and undernutrition are the most common. (msdmanuals.com)
Human Immunodeficiency Virus (HIV) Infection Human immunodeficiency virus (HIV) infection is a viral infection that progressively destroys certain white blood cells and is treated with antiretroviral medications. (msdmanuals.com)
Influenza (Flu) Influenza (flu) is a viral infection of the lungs and airways with one of the influenza viruses. (msdmanuals.com)
In the early days of the pandemic when information on COVID-19 infection was lacking, all COVID-19 positive patients were admitted into acute hospitals for. (annals.edu.sg)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and its corresponding coronavirus disease (COVID-19) was first reported as a cluster of pneumonia cases in. (annals.edu.sg)
According to Dr. Cao, the median duration of viral shedding was 20 days, but it could be as long as 37 days, which has "never been seen before" in an acute respiratory viral infection. (anesthesiaexperts.com)
Experimental studies show that SARS-CoV-2 is able to induce re-infection/reactivation and persistent infection in the same manner as seen with other viral infections. (wsws.org)
These medications act by suppressing the immune system, leaving the patient exposed to severe infection and at risk of cancer. (hrb.ie)
We recently provided evidence that the generation of endogenous extracellular vesicles (EVs) engineered for the incorporation of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 Nucleocapsid (N) protein induced immunity in the lungs of K18-hACE2 transgenic mice, which then can survive the lethal virus infection. (nature.com)
Rabies is a lethal viral infection of humans. (scienceofhealthy.com)
The observation that infections have characteristic distances over which they can be transmitted reflects factors including greater concentrations of infectious respiratory particles closer to infected individuals and differences in pathogen-specific factors such as the inhaled dose required to cause infection and the amount of time that a specific pathogen is able to remain infective. (cdc.gov)
The need to update the CDC guideline on isolation precautions to reflect this more up-to-date scientific view of how respiratory infections are transmitted was one of the important motivations for CDC to ask the Healthcare Infection Control Practices Advisory Committee (HICPAC) to undertake an update. (cdc.gov)
It was developed to be administered orally so that it can be prescribed at the first sign of infection or, pending clinical success of the rest of the EPIC development program and subject to regulatory authorization, at first awareness of an exposure - potentially helping patients avoid severe illness (which can lead to hospitalization and death) or avoid disease development following contact with a household member who contracts COVID-19. (starkvilledailynews.com)
The study concludes: We report that chloroquine has strong antiviral effects on SARS-Coronavirus infection of primate cells. (waccobb.net)

The American Hospital Association's "best guess" of the worst case scenario is that 1% of people in the United States who develop COVID-19, the disease that the novel coronavirus causes, could require mechanical ventilation in hospital as a result of ARDS. (medicalnewstoday.com)
In an article in The Journal of Trauma and Acute Care Surgery , the doctors note that characteristic fibrous deposits and tiny blood clots called "microthrombi" are often present in the lungs of patients with ARDS. (medicalnewstoday.com)
We're hearing anecdotally that a subset of patients with COVID-19-induced ARDS are clotting abnormally around their catheters and [intravenous] lines," says senior author Dr. Michael B. Yaffe, Ph.D., an acute care surgeon at the medical center. (medicalnewstoday.com)
Although not completely understood, the mechanisms of MSC actions in acute models of ARDS include the release of paracrineanti-inflammatory and antibacterial peptides and mitochondrial transfer through cell-cell contact with damaged alveolar epithelial cells in the absence of permanent cell engraftment [9, 15-17]. (justia.com)
And then certainly critical illness and you'll hear about that by our presenters, which include respiratory failure, or ARDS, septic shock, multi-organ dysfunction and failure. (cdc.gov)

This virus can produce a severe pneumonia that has killed over 230,000 people so far, was detected for the first time late 2019 in Wuhan (China), and has spread all over the world due, in part, to the difficulty of detecting and isolating asymptomatic or mild-symptomatic cases. (frontiersin.org)
COVID-19 pneumonia, produced by the novel coronavirus SARS-CoV-2, has become a global public threat a few months after several cases were reported late 2019 in Wuhan, China [ 1 - 6 ]. (frontiersin.org)
previously known as 2019-nCoV), from patients with viral pneumonia (COVID-19). (arquivosdeorl.org.br)
At the end of December 2019, in the city of Wuhan, People's Republic of China, a pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first described. (lww.com)
Mediators of TMA syndromes overlap with those released in cytokine storm, suggesting close connections between ineffective immune responses to SARS-CoV-2, severe pneumonia and life-threatening microangiopathy. (nature.com)
Correspondingly, alteration of zinc status significantly affects immune response resulting in increased susceptibility to inflammatory and infectious diseases including acquired immune deficiency syndrome, measles, malaria, tuberculosis, and pneumonia ( 5 ). (spandidos-publications.com)
An acute respiratory syndrome, lung failure, and fulminant pneumonia are major lung diseases present in viral infections of current interest, some viral infections also cause extrapulmonary diseases including rhabdomyolysis and encephalopathy through cytokine storms [12,13]. (justia.com)
For the remaining cases that progress to severe (14%) and critically ill (5%) status, however, clinicians must be prepared to treat severe pneumonia, respiratory failure requiring mechanical ventilation, shock, and multiorgan failure requiring admission to the ICU. (anesthesiaexperts.com)
And that can be mild illness, uncomplicated upper respiratory tract signs and symptoms to moderate, mild to moderate pneumonia without the need for supplemental oxygen to more moderate to severe pneumonia requiring supplemental oxygen and potentially other forms of oxygen delivery support. (cdc.gov)

This literature review was therefore conducted to describe the burden of epidemic- and pandemic-prone acute respiratory infections (ARI) in the Region which may help in the development of evidence-based disease prevention and control policies. (who.int)
Les infections identifiées comprenaient les infections respiratoires aiguës (IRA), la grippe aviaire A(H5N1), la grippe A(H1N1)pdm09 et l'infection par le coronavirus du syndrome respiratoire du Moyen-Orient (MERS-CoV). (who.int)
Their immune systems have evolved in such a way as to suppress any inflammatory response to viral infections, thereby allowing them to become tolerant hosts for evolving viruses, and consequently provide major reservoirs of zoonotic viruses. (wikipedia.org)
This review article gives details of the mechanisms involved in a cytokine storm (an uncontrolled inflammatory response) and current treatment options, before discussing the immune-balancing and anti-inflammatory potential of healthy nutrition in reducing susceptibility to developing infections. (nutrition-evidence.com)
In this review, we discuss some of the anti-inflammatory therapies that are currently under investigation intended to dampen the cytokine storm of severe COVID-19 infections. (nutrition-evidence.com)
This review speculates the importance of nutrition as a mitigation strategy to support immune function amid the COVID-19 pandemic, identifying food groups and key nutrients of importance that may affect the outcomes of respiratory infections. (nutrition-evidence.com)
Viral ills, for now, are hard to treat, although medical science has made progress in detecting and preventing infections and reducing their harms. (patrickmalonelaw.com)
Insects like mosquitos and ticks, of course, host and transmit many kinds of viral infections, including yellow fever, dengue, and encephalitis. (patrickmalonelaw.com)
This article provides a critical literature review and pooled analysis of diagnostic accuracy of the fully-automated Siemens SARS-CoV-2 Antigen (CoV2Ag) chemiluminescent immunoassay for diagnosis of acute SARS-CoV-2 infections. (degruyter.com)
Earlier data demonstrate that populational Zn status is associated with the prevalence of respiratory tract infections in children and adults ( 6 , 7 ). (spandidos-publications.com)
We have probably been helped by the advent of Summer when coronavirus infections tend to become less of a problem for reasons we don't fully understand. (globalchange.com)
Disclosed are means, methods and compositions of matter useful for treatment of lung inflammation associated with viral and bacterial infections, as well as with systemic inflammation, through administration of umbilical cord blood derived plasma-based compositions. (justia.com)
subtype (i.e. avian influenza viruses to infections such as avian influenza and For this review we included pub- including H5N1, H7N9, H7N2 and Middle East respiratory syndrome cor- lished and unpublished reports of the H9N2, swine flu/pandemic influenza onavirus (MERS-CoV). (who.int)
People who have too few T cells or too few NK cells have problems controlling certain infections, especially viral, fungal, and parasitic infections. (msdmanuals.com)
Severe lymphocyte deficiencies can result in uncontrolled infections that can be fatal. (msdmanuals.com)
A spectrum of immune dysregulation has been described following SARS-CoV-2 infections-from the cytokine storm in the acute phase, to hyperinflammatory syndromes that occur after. (annals.edu.sg)
Obesity is a risk factor for both susceptibility to infections including postoperative infections and other nosocomial infections and the occurrence of a more severe disease course. (hrb.ie)
Coronaviruses cause severe respiratory and intestinal infections in animals and humans. (scienceofhealthy.com)
The uncontrolled and frequent use of antibiotics even for treatment of common infections has given rise to antimicrobial resistance AMR and the microbes are termed as multidrug resistant organisms (MDRO's). (scienceofhealthy.com)
The COVID-19 pandemic has forever changed the approach we take in healthcare settings to protect healthcare personnel, patients, and others from transmission of respiratory infections. (cdc.gov)

During the recent global outbreak of severe acute res- randomized trial of ribavirin therapy for SARS will illus- piratory syndrome (SARS), thousands of patients received trate these challenges. (cdc.gov)
Recent examples include the SARS-related coronaviruses, which have caused the 2002-2004 outbreak of SARS (SARS-CoV-1) and the 2019-21 pandemic of COVID-19 (SARS-CoV-2). (wikipedia.org)
The disturbing possibility that a Wuhan virology lab is the source of the outbreak would not only inculpate Chinese researchers, but the global health establishment itself, which cooperated in the research through a collaboration between U.S. health agencies, the communist Chinese government, and the United Nations. (naturalnews.com)
A punishing outbreak of one - a coronavirus now named Covid-19 - exploded out of the city of Wuhan in central China. (patrickmalonelaw.com)
This is a question that billions of people are wondering early 2020 due to the outbreak of the novel coronavirus SARS-CoV-2. (frontiersin.org)
In practice, the healthcare system cannot sustain an uncontrolled outbreak, and stronger containment measures are now the only realistic option to avoid the total collapse of the intensive care unit (ICU) system. (arquivosdeorl.org.br)
notified that the rapid outbreak of COVID-19 disease results in global pandemic within three months after emerging. (scientificasia.org)
The outbreak of the COVID-19 virus in 2019 had rapidly developed into a global pandemic, causing more than 6.8 million deaths and impacting the. (annals.edu.sg)
The viruses were not believed to be highly pathogenic to humans until the year 2002 and 2003 when first outbreak of novel coronavirus strain, Severe Acute Respiratory Syndrome SARS was reported in Guangdong province, China. (scienceofhealthy.com)

Epidemiologic models for prediction of Coronavirus Disease 2019 (COVID-19) have shown many limitations because of unpredictable dynamics of the new viral agent SARS-CoV-2 in environment and society. (preprints.org)
Unlike the coronaviruses HCoV-229E, HCoV-OC43, HCoV-NL63, and HCoV-HKU, that are pathogenic in humans and are associated with mild clinical symptoms, SARS-CoV-2 resembles both SARS-CoV and Middle East respiratory syndrome (MERS), with the potential to cause more severe disease. (frontiersin.org)
A critical distinction is that CoVs that infect the upper respiratory tract tend to cause a mild disease, whereas CoVs that infect both upper and lower respiratory tracts (such as SARS-CoV-2 appears to be) may cause more severe disease. (frontiersin.org)
Coronavirus disease (COVID)-19, the disease caused by SARS-CoV-2, has since spread around the globe as a pandemic. (frontiersin.org)
The recognition of SARS as a transmissible disease included for coverage of a presumptive viral illness, given prompted international efforts to identify its cause and its in vitro activity against a variety of RNA and DNA control its spread. (cdc.gov)
As data on pathogenesis accrued, a hypothesis dramatic, with the identification of the SARS-associated suggesting that lung injury may be immune mediated led coronavirus (SARS-CoV) and the control of SARS out- to widespread use of corticosteroids in combination with breaks in all affected countries (1-4). (cdc.gov)
Some may argue that such a trial would have non-specific, as all patients with febrile respiratory illness- been valuable, given the continued use of ribavirin for the es, regardless of etiology, will be included if they have any treatment of SARS in Hong Kong and China (13). (cdc.gov)
The novel coronavirus disease (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has engulfed the world, affecting more than 180 countries. (nutrition-evidence.com)
Coronavirus disease 19 (COVID-19), caused by the severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2), has been implicated in having post-COVID-19 sequelae in both adults and children. (springer.com)
Transplacental transfer of vaccine-induced SARS-CoV-2-specific antibodies has been demonstrated, and severe clinical infant outcomes related to COVID-19 are preventable through maternal vaccination ( 2 , 3 ). (cdc.gov)
The Siemens CoV2Ag fully-automated and high-throughput immunoassay approximates the minimum performance criteria for general SARS-CoV-2 antigen testing and displays excellent performance in samples with high viral load, thus representing a valuable screening solution for risk assessment in COVID-19 and for limiting viral spread. (degruyter.com)
Coronavirus disease 2019 (COVID-19), an ongoing pandemic disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become virtually endemic due to universal vaccination and a decreased viral pathogenicity that has gradually developed over time, especially after emergence of the so-called Omicron lineages characterized by high immune escape [ 1 ]. (degruyter.com)
In the recent decades, they have been related to more serious outbreaks, such as severe acute respiratory syndrome (SARS) in 2002 and Middle East respiratory syndrome (MERS) in 2012. (arquivosdeorl.org.br)
The most common are α coronavirus 229E and NL63 and β coronavirus OC43 and HKU1, the viruses responsible for the SARS-CoV and MERS-CoV outbreaks respectively. (arquivosdeorl.org.br)
Recently, a novel coronavirus has been identified, which was initially named 2019-nCoV and then SARS-CoV-2 on February 11, 2020, as it was found to be genetically related to SARS-CoV. (arquivosdeorl.org.br)
The cause of COVID-19 global pandemic is SARS-CoV-2. (ajmb.org)
Coronavirus disease 2019 (COVID-19) emerged in late 2019 by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and posed a global public health emergency. (ajmb.org)
SARS-CoV and the Middle East Respiratory Syndrome (MERS) are also from the betacoronavirus genus. (ajmb.org)
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been responsible for the COVID-19 pandemic, which caused more than 4.5 million deaths worldwide. (bvsalud.org)
The limited vaccination coverage, the continued risk for resistant variants, and the existence of natural reservoirs for coronaviruses, highlight the importance of developing additional therapeutic strategies against SARS-CoV-2 and other coronaviruses. (bvsalud.org)
The unprecedently speedy development of mRNA vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was enabled with previous innovations in nucleoside modifications during in vitro transcription and lipid nanoparticle delivery materials of mRNA. (mdpi.com)
Recent updates are briefly described in the status of mRNA vaccines against SARS-CoV-2, influenza virus, and other viral pathogens. (mdpi.com)
Key features of this disorder include a lack of bleeding risk, only mildly low platelet counts, elevated plasma fibrinogen levels, and detection of both severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and complement components in regions of thrombotic microangiopathy (TMA). (nature.com)
The coronavirus disease 2019 (COVID-19) pandemic has elicited a swift response by the scientific community to elucidate the pathogenesis of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)-induced lung injury and develop effective therapeutics. (ersjournals.com)
We argue that the impaired interferon-I and -III response of severe COVID-19 is reminiscent of severe acute respiratory syndrome-coronavirus (SARS-CoV) and influenza pathobiology, suggesting conserved virulence mechanisms among these viruses. (ersjournals.com)
Specifically, we argue that the hypercoagulable and hyperinflammatory state of severe COVID-19 is a consequence of the expanded tropism of SARS-CoV-2, which allows it to infect vascular endothelial cells, and that cytokine storm physiology contributes to a lesser degree. (ersjournals.com)
The spread of a novel coronavirus (severe acute respiratory syndrome-coronavirus-2, or SARS-CoV-2) has challenged the capacity of healthcare systems and the public health policies of governments worldwide [ 1 ]. (ersjournals.com)
When my team and I first learned about severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease 2019 (COVID-19), we sprang into action, searching the literature to identify the gaps. (polytrendy.com)
SARS-CoV-2 is a coronavirus, a large family of viruses named after the 'crown' of proteins studded on their surface. (polytrendy.com)
The other three (SARS-CoV, SARS-CoV-2 and Middle East respiratory syndrome coronoavirus or MERS-CoV) are more deadly, and thus more well known. (polytrendy.com)
The genomes of SARS-CoV and SARS-CoV-2 are 79 percent similar, but SARS-CoV-2 is most similar to a coronavirus found in bats, RaTG13, sharing 98 percent similarity. (polytrendy.com)
Like SARS-CoV and MERS before it, SARS-CoV-2 spreads primarily through respiratory droplets and contact with contaminated surfaces. (polytrendy.com)
What follows is an expanded version of a briefing by Dr Patrick Dixon at the SARS Summit organised by World Bank's Global Development Learning Network - government leaders from Vietnam, China, Mongolia, Phillipines, Hong Kong and other nations. (globalchange.com)
We have been in an urgent race against time to prevent the risk of a future global SARS pandemic, with numbers of cases in some places doubling in the past every 2 -3 weeks of a disease with 10% mortality - up to 50% in those over 65. (globalchange.com)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a life threatening viral pathogen which is responsible for causing COVID-19 disease all around the world. (scientificasia.org)
reported that SARS-CoV-2 is a single stranded RNA virus (ssRNA) that belongs to the beta Coronavirus family. (scientificasia.org)
The recent appearance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people around the world and caused a global pandemic of coronavirus disease 2019 (COVID-19). (molcells.org)
RNA viruses such as SARS-CoV-2, SARS-CoV-1, and Middle East respiratory syndrome (MERS) is identified by various pattern-recognition receptors, including Toll-like receptors (TLRs) and RIG-I-like receptors (RLRs), and induce the type I IFN responses and IFN-stimulated gene (ISG) expression. (molcells.org)
COVID-19 COVID-19 is an acute respiratory illness that can be severe and is caused by the coronavirus named SARS-CoV-2. (msdmanuals.com)
Thus far, there are no approved therapies for COVID-19, the respiratory illness caused by SARS-CoV-2, but clinicians are exploring a myriad of treatment options, including drugs approved to treat malaria, lupus, rheumatoid arthritis, HIV and Ebola. (anesthesiaexperts.com)
Vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have decreased the burden of the COVID-19 pandemic. (euvolution.com)
Several vaccines were developed and distributed within an unprecedentedly short time in response to the spread of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2. (nature.com)
Experimental and observational data show that an important pathway for transmission of severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) is via inhalation of small particles in the air generated by infected individuals. (cdc.gov)
Diluting indoor air with outdoor air is considered to be effective because severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19, is primarily an airborne contaminant, according to Public Health Ontario (PHO). (constructioncanada.net)
The causative agent, Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), was promptly identified, and determined to be closely related to SARS and the Middle East Respiratory Syndrome (MERS) coronaviruses, which had caused geographically localized outbreaks in 2002-2004 and from 2012 onwards, respectively. (cov19longhaulfoundation.org)
SARS-CoV-2 progressed to a global pandemic with substantial consequences due to its high infectivity and transmissibility, and its ability to cause both a severe respiratory illness, and a systemic disease with fatal consequences for vulnerable populations. (cov19longhaulfoundation.org)
The natural history of coronavirus infectious disease caused by SARS-CoV-2 (COVID-19), is yet to be fully described. (cov19longhaulfoundation.org)
However, a case fatality rate that ranges from 0.5% to nearly 20% depending on age and other risk factors, and the understanding that SARS-CoV-2 is now a well-adapted human pathogen that will continue to cause disease in susceptible populations, makes the development of an effective vaccine a global priority. (cov19longhaulfoundation.org)
The potential for vaccination against SARS-CoV-2 to be associated with disease enhancement is of theoretical concern, given similar observations with other respiratory viruses in general, and in animal models of highly pathogenic coronaviruses in particular [14] . (cov19longhaulfoundation.org)
This coronavirus, named SARS-CoV-2, causes a disease called COVID-19 that can be transmitted from person to person [ 3 , 4 ]. (newvita.com)

Treatment with IFN-α2b with or without arbidol significantly reduced the duration of detectable virus in the upper respiratory tract and in parallel reduced duration of elevated blood levels for the inflammatory markers IL-6 and CRP. (frontiersin.org)
Of these, four (229E, NL63, OC43 and HKU1) typically infect only the upper respiratory tract and cause mostly minor symptoms. (polytrendy.com)

The novel coronavirus disease 2019 (COVID-19) has become a global public health emergency since patients were first detected in Wuhan, China, in December 2019. (justia.com)

Induction of effective immunity in the lungs should be a requisite for any vaccine designed to control the severe pathogenic effects generated by respiratory infectious agents. (nature.com)
However, nothing is known about the ability of the N-specific CD8 + T cell immunity in controlling viral replication in the lungs, a major pathogenic signature of severe disease in humans. (nature.com)

This review provides a descriptive summary of the burden of acute respiratory diseases in the Region, but there still remains a lack of necessary data. (who.int)

therapy was used to provide coverage against a broad dif- ferential of bacterial and viral pathogens. (cdc.gov)
This study warrants further development of aerosol vaccine strategies against respiratory pathogens, including TB and COVID-19.Trial registrationClinicalTrial.gov, NCT02337270.FundingThe Canadian Institutes for Health Research (CIHR) and the Natural Sciences and Engineering Research Council of Canada funded this work. (bvsalud.org)
The importance of anticipating transmission through air and using respiratory protection when caring for those with new and emerging pathogens represents another lesson learned from the COVID-19 pandemic. (cdc.gov)
Classic examples of VAED are atypical measles and enhanced respiratory syncytial virus (RSV) occurring after administration of inactivated vaccine for these pathogens. (cov19longhaulfoundation.org)

There are several reasons to be worried about, including faster transmission, more severe illness, decreased neutralisation by antibodies and or reduced efficiency of treatment and vaccines.The pandemic is far from over. (metropolisindia.com)
The severity of illness may vary from mild and inconvenient to severe and life threatening. (medscape.com)
In late 2019, a novel severe respiratory illness emerged in Wuhan, China [13] . (cov19longhaulfoundation.org)
Additional Phase 2/3 clinical trials are ongoing in adults at standard risk (i.e., low risk of hospitalization or death) of progressing to severe illness, and in those who have been exposed to the virus through household contacts. (starkvilledailynews.com)
So just as an overview, some-- one very large study of cases in China reported that the vast majority of patients with COVID-19 do in fact have mild to moderate illness, however, 19% had severe or critical illness. (cdc.gov)

The study notes that other coronaviruses, including Middle East respiratory syndrome coronavirus (MERS-CoV), have already been demonstrated to lead to cancer. (wsws.org)

The virus has been detected in nasopharyngeal swabs, sputum, lower respiratory tract secretions, blood and feces using RT-PCR [real-time polymerase chain reaction] and/or NGS [next-generation sequencing] methods. (anesthesiaexperts.com)
Vaccine-associated enhanced respiratory (VAERD) disease refers to disease with predominant involvement of the lower respiratory tract. (cov19longhaulfoundation.org)

As journalists and government agencies continue to investigate the origins of the COVID-19 pandemic, it appears increasingly likely that the novel coronavirus was unleashed, inadvertently or not, by a Chinese virology lab in Wuhan, where dangerous "gain of function" research was being done on bat coronaviruses of the COVID-19 variety. (naturalnews.com)
If it is ultimately proven true that the Wuhan Institute of Virology unleashed the novel coronavirus upon the world, then not only China, but the United States and the global health establishment as well will be implicated in the worst socioeconomic and political crisis of the 21st century, a pandemic that has now taken the lives of over 400,000 people and has wreaked havoc on the global economy. (naturalnews.com)
Dr. Cao, who has been treating patients on the front lines in Wuhan, China, emphasized that COVID-19 is neither a localized disease nor limited to the respiratory tract. (anesthesiaexperts.com)
Coronavirus disease 2019 (COVID-19), which originally came from Wuhan, China, is currently considered as a significant threat towards global health. (springeropen.com)

Sadly, the vulnerable and immunocompromised in our societies seem to be more susceptible to severe COVID-19 complications. (nutrition-evidence.com)
Diabetes is considered as one of the main contributing factors of high morbidity and mortality rates globally, where, uncontrolled diabetes is associated with macro- and micro-vascular complications affecting patient's health wellbeing and survival. (actascientific.com)

During the cytokine storm, the innate immune system causes an uncontrolled and excessive release of pro-inflammatory signaling molecules called cytokines. (wsws.org)
The clinical study, which involved one hundred patients admitted to hospital for severe COVID-19, notes that the cytokine storm can adversely affect hormone production and produce inflammation of the thyroid. (wsws.org)

ARB displays antiviral activity against respiratory viruses, including coronaviruses ( 4 ). (frontiersin.org)
As well as causing disease, emergent viruses can also have severe economic implications. (wikipedia.org)
They are associated with more zoonotic viruses per host species than any other mammal, and molecular studies have demonstrated that they are the natural hosts for several high-profile zoonotic viruses, including severe acute respiratory syndrome-related coronaviruses and Ebola/Marburg hemorrhagic fever filoviruses. (wikipedia.org)
Coronaviruses are a relatively common family of respiratory viruses and the second most frequent cause of common cold after rhinoviruses. (arquivosdeorl.org.br)

The antiviral effect appeared similarly strong when the viral challenge was carried out 3 months after boosting, and associated with the persistence of N-specific CD8 + T-resident memory lymphocytes. (nature.com)

Although not being the first viral pandemic to affect humankind, we are now for the first time faced with a pandemic caused by a coronavirus. (bvsalud.org)

ABSTRACT There are gaps in the knowledge about the burden of severe respiratory disease in the Eastern Mediterranean Region (EMR). (who.int)

Insights here endeavor, whenever possible, to clarify these problems to increase the knowledge of the sources and factor determining the emergence of new viral agents in order to design optimal response policies to face next pandemic diseases similar to COVID-19. (preprints.org)
Global public health bodies and governments have ignited strategies and issued advisories on various handwashing and hygiene guidelines, social distancing strategies, and, in the most extreme cases, some countries have adopted "stay in place" or lockdown protocols to prevent COVID-19 spread. (nutrition-evidence.com)
The researchers at the WIV specialized in bat coronaviruses that are most closely related to the novel coronavirus that causes COVID-19, and they admit that they sampled at least one such virus that was identical in 96% of its genome. (naturalnews.com)
Persistent or new symptoms after acute coronavirus disease 19 (COVID-19) are a well-known entity in the adult population, with an estimated global prevalence of 0.43 (95% CI: 0.39, 0.46) [ 1 ]. (springer.com)
Expectant mothers should remain current with COVID-19 vaccination to protect themselves and their infants from hospitalization and severe outcomes associated with COVID-19. (cdc.gov)
The disease caused by the new coronavirus was named COVID-19. (arquivosdeorl.org.br)
9 As the situation rapidly evolved the coronavirus disease 2019 (COVID-19) pandemic commenced. (lww.com)
Visit our coronavirus hub for the most recent information on COVID-19. (medicalnewstoday.com)
As part of this blood clotting-inflammation cycle, the uncontrolled development of microclots in the small blood vessels of the lungs and the microfibrin plugs in the small air sacs of some COVID-19 patients contribute to severe breathing difficulties. (medicalnewstoday.com)
For more advice on COVID-19 prevention and treatment, visit our coronavirus hub . (medicalnewstoday.com)
Reports of widespread thromboses and disseminated intravascular coagulation (DIC) in patients with coronavirus disease 19 (COVID-19) have been rapidly increasing in number. (nature.com)
One picture is coming into better focus, however, which suggests that an immune-triggered, complement-mediated thrombotic microangiopathy (TMA) is surprisingly common in patients with coronavirus disease 19 (COVID-19). (nature.com)
Like the better known TMA syndromes, this COVID-19-related syndrome is characterized by organ failure caused by widespread microclots in capillaries and other small vessels. (nature.com)
Zinc status is also tightly associated with risk factors for severe COVID‑19 including ageing, immune deficiency, obesity, diabetes, and atherosclerosis, since these are known risk groups for zinc deficiency. (spandidos-publications.com)
Similar to influenza, advanced age has emerged as the leading host risk factor for developing severe COVID-19. (ersjournals.com)
Finally, we explore hallmarks of ageing that could explain the association between advanced age and susceptibility to severe COVID-19. (ersjournals.com)
We also explore the potential aetiologies of the lymphopenia associated with severe COVID-19: the virus' expanded tropism, elevated serum cytokines (particularly interleukin-6 and tumour necrosis factor-α), and excessive lymphocyte recruitment to the lungs. (ersjournals.com)
Finally, we discuss how certain hallmarks of ageing (epigenetic alterations, mitochondrial dysfunction, telomere attrition, cellular senescence, and altered intercellular communication) predispose the ageing population to severe COVID-19. (ersjournals.com)
Dr. Messonnier is the director of the National Center for Immunization Respiratory Diseases and senior official for CDC's COVID-19 response. (cdc.gov)
Objective Among treatment options for coronavirus infectious disease 2019 (COVID-19), well-studied oral medications are limited. (bvsalud.org)
We conducted a multicenter non-randomized, uncontrolled single-arm prospective study to assess the efficacy and safety of favipiravir for patients with COVID-19. (bvsalud.org)
The multivariate logistic regression model showed that severe COVID-19 among HCWs in Sabah was associated with those do not receive any COVID-19 vaccination (aOR 6.061, 95% CI 3.408 - 10.780), underlying co-morbidity (aOR 3.335, 95% CI 2.183 - 5.096), and female (aOR 1.833, 95% CI 1.090 - 3.081). (biomedcentral.com)
Early screening and aggressive co-morbidity treatment among HCWs are essential for public health practitioners to prevent severe COVID-19 disease. (biomedcentral.com)
Hence, it is crucial to study the factors associated with severe COVID-19 disease in HCWs. (biomedcentral.com)
Monitor your symptoms and do get an RT-PCR test done if you found yourself facing symptoms suggestive of COVID-19 The Delta variant In view of the growing COVID-19 pandemic throughout the world, health officials are evaluating certain coronavirus mutations and variants that could be more contagious or deadly than the original strain. (metropolisindia.com)
Hence, there is a large unmet need for a safe and effective treatment for COVID-19 infected patients, especially in the most severe cases. (justia.com)
hematological and biochemical admission day laboratory findings of moderate to severe degree hospitalized COVID-19 patients were analyzed. (scientificasia.org)
It has been suggested that uncontrolled, exaggerated inflammation contributes to the adverse outcomes of COVID-19. (molcells.org)
From this viewpoint, we summarize the changes in innate immune cells seen in moderate and severe COVID-19 and highlight the roles of pro-inflammatory cytokines and type I interferons (IFNs) in the clinical outcomes. (molcells.org)
[ 1 ] Prior to the coronavirus disease 2019 (COVID-19) pandemic, an estimated 179 million cases of acute gastroenteritis occurred every year in the United States. (medscape.com)
Because vascular endothelial cells express high levels of angiotensin-converting enzyme 2, anticoagulation therapy should be initiated for patients with severe COVID-19 unless otherwise contraindicated, he said. (anesthesiaexperts.com)
Peripheral lymphocyte counts, mainly T cells, also were substantially reduced in patients with severe COVID-19, with severe lymphopenia observed until death in nonsurvivors. (anesthesiaexperts.com)
Finding this pattern in someone sick with COVID-19 appears to predict with 96 percent accuracy who will go on to have severe disease. (snexplores.org)
As the COVID-19 pandemic continues its global rampage unabated, there is a growing body of research on the damaging effects the disease can have on virtually every organ system. (wsws.org)
A recent study published in the journal Science discussed variant-adapted boosters for coronavirus disease 2019 (COVID-19). (euvolution.com)
The phenomenon of p ost-acute sequelae of COVID-19 (PASC, also known as long COVID-19) remains an enduring mystery to researchers and clinicians. (asm.org)
Recently, Mucormycosis made serious disarray in India during the second wave (among April and June 2021) of the tragical COVID-19 upsurge by its startling and severe overflow with up to half the death rate. (fortuneonline.org)
The current COVID-19 pandemic is unprecedented in the 21st century and the global response draws on the lessons learned from other disease outbreaks over the past several decades. (who.int)
The current global COVID-19 public health emergency underscores the need to accelerate the development of COVID-19 candidate vaccines. (who.int)
Coronavirus disease 2019 (COVID-19) is a current global pandemic. (springeropen.com)
Pfizer Inc. (NYSE: PFE) announced today that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) issued a positive opinion recommending the conditional marketing authorization (CMA) of Pfizer's PAXLOVID™ (nirmatrelvir [PF-07321332] tablets and ritonavir tablets) for the treatment of COVID-19 in adults who do not require supplemental oxygen and who are at increased risk for progressing to severe COVID-19. (starkvilledailynews.com)
Corona virus 2019 (COVID-19) disease is a globally infectious disease caused by Severe Acute Respiratory Syndrome-Coronavirus-2 that is emerging and rapidly spreading. (actascientific.com)

Acute kidney injury (AKI) is a life-threatening disease with high mortality characterized by an abrupt decrease of the kidney glomerular filtration rate, extra-kidney consequences (cardiovascular diseases, lung injury, neurological impairment) and high risk of secondary chronic kidney disease (CKD). (hrb.ie)
Outdoor and indoor air pollution cause respiratory and other diseases, which can be fatal. (who.int)

The symptoms of delta variants are similar to those seen with the original coronavirus strain including a persistent cough, headache, fever, and sore throat. (metropolisindia.com)

We focus the discussion on the design and been associated with clinical successes in uncontrolled implementation of randomized controlled trials of candi- reports (10,11). (cdc.gov)
In less than four months, research scientists and health professionals have identified a novel coronavirus, sequenced its genome, charted the clinical course of disease it causes, and begun trials for investigational vaccines and treatments. (anesthesiaexperts.com)
For the 5% of patients who progress to critically ill status, respiratory failure, shock or multiorgan dysfunction are possible clinical outcomes. (anesthesiaexperts.com)
IAH in SCD manifests as febrile haemolytic crisis with clinical and laboratory features of severe anaemia or pancytopenia. (bvsalud.org)

There are now a wide variety of global metrics. (preprints.org)

Adding to the potential scandal is the futile motive for such dangerous research: an obsessive drive for vaccines and anti-viral treatments to address mass outbreaks of disease, an approach that has been largely discredited over more than 60 years of experience. (naturalnews.com)
BackgroundAdenovirus-vectored (Ad-vectored) vaccines are typically administered via i.m. injection to humans and are incapable of inducing respiratory mucosal immunity. (bvsalud.org)
Moreover, the Delta plus variant of coronavirus, due to its mutation of K417N spike protein, may escape vaccines and antibodies more than the Delta variant. (metropolisindia.com)
Unfortunately, no drugs or vaccines have been approved for the treatment of human coronaviruses, but there is an urgent need for in-depth research on emerging human infectious coronaviruses. (newvita.com)

Rather, it might be more similar to complement-mediated TMA syndromes, which are well known to rheumatologists who care for patients with severe systemic lupus erythematosus or catastrophic antiphospholipid syndrome. (nature.com)
Another common finding among severe and critical patients is abnormal coagulation. (anesthesiaexperts.com)
Although the disease is not limited to the lungs, severe disease (seen in 14% of patients) is characterized by dyspnea, hypoxia or greater than 50% lung involvement on imaging within 24 to 48 hours. (anesthesiaexperts.com)
According to a primer drafted by the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) Acute Care Committee, however, early data suggest that the majority of critically ill patients are suffering from only hypoxia and "only require management of hypoxemia using Positive End Expiration Pressure (PEEP), FiO2, and possibly prone positioning. (anesthesiaexperts.com)
Il s'agit d'une étude transversale, monocentrique et descriptive, durant 12 mois, incluant les patients âgés d'au moins 18 ans admis en réanimation polyvalente pour un sepsis ou choc septique. (bvsalud.org)
SCD patients with fever, severe anaemia or pancytopenia should be investigated for early diagnosis and prompt treatment of IAH, which is a life- threatening haematological emergency for which transfusion therapy alone may not suffice. (bvsalud.org)

Immunization with the primary vaccine series induced high antibodies against the viral spike but declined substantially after a few months. (euvolution.com)
While IAEMH is associated with severe anaemia due to intravascular haemolysis caused by red cell invasion, oxidative injury, auto-antibodies, and/or pathogen-haem interaction, IAIMH is associated with haemophagocytic tri-lineage destruction of haematopoietic precursors in the bone marrow. (bvsalud.org)

Echocardiography follow-up results showed non-significant changes in mean ejection fraction, global longitudinal strain and pulmonary artery pressure (p>0.05). (bvsalud.org)

Viral emergence in humans is often a consequence of zoonosis, which involves a cross-species jump of a viral disease into humans from other animals. (wikipedia.org)
There are seven identified coronaviruses that affect humans. (arquivosdeorl.org.br)
Of the hundreds of different coronaviruses known to man, just seven are known to infect humans. (polytrendy.com)

In another embodiment, umbilical cord blood plasma is administered with immune stimulatory agents in order to concurrently inhibit propagation of viral load in the lung while suppressing pulmonary deficiencies. (justia.com)
Multiple myeloma (MM) is an incurable cancer in which uncontrolled plasma cell proliferation disrupts the bone marrow environment and impairs immune function. (hrb.ie)

Adoptive transfer of mesenchymal stromal cells (MSCs) ameliorates experimentally induced acute lung injury in preclinical animal models and in ex vivo perfused human lungs [6-14]. (justia.com)

We have to keep in mind that severe and critical cases will have acute cardiac injury, and some of these may be complicated with myocardial infarction," said Dr. Cao, a professor of pulmonary and critical medicine at the China-Japan Friendship Hospital and Capital Medical University, in Beijing. (anesthesiaexperts.com)

Thus, it's not surprising that we see viremia in severe cases because this disease can spread from the lungs to other organs, including the heart. (anesthesiaexperts.com)
At the same time points, viral replication extents in the lungs were evaluated. (nature.com)

Of the 3040 HCWs, 2948 (97.0%) HCWs were mild, whereas 92 (3.0%) were severe. (biomedcentral.com)

In the latest study, the dogs sometimes mistook another respiratory virus for the coronavirus , Grandjean and his colleagues found. (snexplores.org)
ACE2 is recognized by the receptor-binding domain (RBD) of the virus spike protein, while TMPRSS2 is needed for the proper processing of the spike protein required for viral entry into the cell. (polytrendy.com)
With the virus reaching as far as the US, UK and Australia, the World Health Organization declared it a "global emergency" on Thursday. (yahoo.com)
Unfortunately, in that same time span, the virus has infected hundreds of thousands around the world, wreaking havoc on health care systems and the global economy. (anesthesiaexperts.com)
While respiratory catalogs are the most predominant feature of this disease, with time it has been initiate that the virus can include almost any organ in the human body. (fortuneonline.org)
It maintains the virus is transmitted primarily at short range through respiratory particles ranging in size from large droplets to smaller droplets (aerosols) . (constructioncanada.net)

Anatomy10

Organisms27

Diseases22

Chemicals and Drugs37

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes29

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture3

Information Science5

Named Groups2

Health Care17

Geographicals7

Distress syndrome9

Confirmed COVID-193

Infection36

ARDS5

Pneumonia9

Infections20

Outbreak9

SARS50

Upper respi2

Novel coronavirus disease1

Pathogenic2

Burden of acute respiratory diseases1

Pathogens4

Illness5

MERS-CoV1

Lower respi2

Wuhan4

Complications2

Cytokine storm2

Viruses4

Antiviral1

Pandemic caused1

ABSTRACT1

COVID42

Diseases2

Symptoms1

Clinical4

Metrics1

Vaccines4

Patients6

Antibodies2

Strain1

Humans3

Immune2

Lung1

Pulmonary1

Lungs2

Mild1

Virus6