Von Hippel-Lindau Tumor Suppressor Proteinvon Hippel-Lindau DiseasePancreatic CystHypoxia-Inducible Factor 1, alpha SubunitKidney NeoplasmsCarcinoma, Renal CellProcollagen-Proline DioxygenaseTumor Suppressor Protein p53Ubiquitin-Protein LigasesUbiquitinationNobel PrizeTumor Suppressor ProteinsGenes, Tumor SuppressorHemangioblastomaRho FactorUbiquitinTumor Suppressor Protein p14ARFProto-Oncogene Proteins c-mdm2Retinoblastoma ProteinCell Line, TumorUbiquitinsProtein BindingMutationMolecular Sequence DataProteasome Endopeptidase Complexvon Willebrand FactorNuclear ProteinsCell LineLigasesGenes, p53TransfectionApoptosisDNA-Binding ProteinsGene Expression Regulation, NeoplasticTranscription FactorsAmino Acid SequenceSignal TransductionNeurofibromin 2Cell CycleCell Cycle ProteinsAdenomatous Polyposis Coli ProteinPhosphorylationProto-Oncogene ProteinsProtein Structure, TertiaryTumor Cells, CulturedUbiquitin-Conjugating EnzymesCyclin-Dependent Kinase Inhibitor p16Base SequencePTEN PhosphohydrolaseGenes, SuppressorCyclin-Dependent Kinase Inhibitor p21DNA DamagePromoter Regions, GeneticCell Transformation, NeoplasticDown-RegulationCell ProliferationTranscription, GeneticProteinsRepressor ProteinsHeLa CellsBlotting, WesternNeoplasm ProteinsNeoplasmsCyclinsCell DivisionTranscriptional ActivationCarrier ProteinsRNA, MessengerE2F Transcription FactorsBinding SitesRNA, Small Interferingvon Willebrand DiseasesRNA InterferenceRecombinant Fusion ProteinsGene SilencingProtein-Serine-Threonine KinasesCells, CulturedTumor Markers, BiologicalGene Expression RegulationImmunoprecipitationFibroblastsCullin ProteinsCell HypoxiaCell NucleusSuppressor of Cytokine Signaling ProteinsE2F1 Transcription FactorLysineReverse Transcriptase Polymerase Chain ReactionProteolysisUbiquitin ThiolesteraseModels, BiologicalGene DeletionOncogene Proteins, ViralHEK293 CellsTrans-ActivatorsSuppression, GeneticCysteine EndopeptidasesDNA MethylationLoss of HeterozygosityTranscription Factor DP1