• With 35,000 genes and hundreds of thousands of protein states to identify, correlate, and understand, it no longer suffices to rely on studies of one gene, gene product, or process at a time. (genomicglossaries.com)
  • Orthologs are sequences of genes that evolved from a common ancestor and can be traced evolutionarily through different species. (pharmaceuticalintelligence.com)
  • Hybridization analyses utilizing a custom-made complementary DNA microarray c ontaining granulosa/cumulus expressed sequence tags (ESTs) from subtracted libraries and an Affymetrix GeneChip have been per shaped to determine particular genes expressed in follicles resulting in a being pregnant. (serpins.com)
  • In this context, we present a nanopore-based assay for rapid (24 hours) sequencing of six genes ( NPM1, FLT3, CEBPA, TP53, IDH1 , and IDH2 ) that are recurrently mutated in AML. (mdpi.com)
  • The MDC is fused to 20 amino acid His-Tag at N-terminus purified by proprietary chromatographic techniques. (neobiolab.com)
  • The workflow proposed can potentially enable all basic molecular biology laboratories to perform detailed targeted gene sequencing analysis in AML patients, in order to define the prognosis and the treatment. (mdpi.com)
  • Among the RING-finger ligases, the cullin-RINGE3 ligases (CRLs) represent a diverse group that includes ligases such as the Skp1 /Cullin/F-box (SCF) protein complex and the anaphase promoting complex/cyclosome (APC/C). These CRLs have important roles in the ubiquitination of proteins involved in the cell cycle. (pberghei.eu)
  • Poly-ubiquitination serves as a signal for degradation of the target protein by the 26S proteasome. (activemotif.com)
  • Mono-ubiquitination is a regulatory modification that alters the function of many nuclear proteins. (activemotif.com)
  • We own protein expression technology based on a series of protein expression and purification technology, including protein expression technology shown by Baculovirus outer membrane proteins (OMP), and membrane protein expression technology, etc. (cusabio.com)
  • Dig2, a murine Scylla/Charybdis homolog, is also a stress-responsive protein induced by a variety of treatments including dexamethasone, thapsigargin, tunicamycin, and heat shock (Wang, 2003). (sdbonline.org)
  • We find that Tor2, the catalytic subunit of the TORC1 complex in fission yeast, targets a conserved nuclear RNA elimination network, particularly the serine and proline-rich protein Pir1, to control gene expression through RNA decay and facultative heterochromatin assembly. (nih.gov)
  • Compared with traditional protein expression systems, many processes are omitted in vitro E.coli, such as the transformation of plasmids, cell culture, collection, crushing and centrifugation, etc., which greatly improves working efficiency. (cusabio.com)
  • When the YMYL within NiV M was mutated, VLP release was abolished and M was relocalized to the nucleus, but the mutant M proteins retained oligomerization activity. (nih.gov)
  • When YMYL was fused to a late-domain mutant of the Ebola virus VP40 matrix protein, VP40 budding was restored. (nih.gov)
  • Cullin serves as a scaffold protein which N-terminally binds to SKP1 and C-terminally binds to a RING- finger protein (RING-box protein 1 - RBX1) and an E2 ubiquitin-conjugating enzyme. (pberghei.eu)
  • It is related in sequence and structure to ACTIN and binds ATP. (nih.gov)
  • Arp2-3 complex binds WASP PROTEIN and existing ACTIN FILAMENTS, and it nucleates the formation of new branch point filaments. (nih.gov)
  • HN - 2006 BX - Arp2-3 Complex MH - Actin-Related Protein 3 UI - D051378 MN - D5.750.78.730.246.750 MN - D12.776.220.525.246.750 MS - A component of the Arp2-3 complex that is related in sequence and structure to ACTIN and that binds ATP. (nih.gov)
  • F-box domains are commonly found in concert with other protein-protein interaction motifs, such as leucine-rich, WD repeat and ankyrin repeats, which mediate interactions with their substrate-specific interaction motif. (pberghei.eu)
  • F-box proteins generally contain a ~50 amino acid F-box domain which functions as a receptor by binding to the SCF complex. (pberghei.eu)
  • HN - 2006(1981) BX - Cofilins MH - Actin-Related Protein 2 UI - D051377 MN - D5.750.78.730.246.500 MN - D12.776.220.525.246.500 MS - A PROFILIN binding domain protein that is part of the Arp2-3 complex. (nih.gov)
  • HN - 2006(1998) MH - Actin-Related Protein 2-3 Complex UI - D051376 MN - D5.750.78.730.246 MN - D12.776.220.525.246 MS - A complex of seven proteins including ARP2 PROTEIN and ARP3 PROTEIN that plays an essential role in maintenance and assembly of the CYTOSKELETON. (nih.gov)
  • In order to begin to characterize the assembly process for the highly lethal, emerging paramyxovirus Nipah virus (NiV), we have examined the budding of NiV M. We demonstrated that expression of the NiV M protein is sufficient to produce budding virus-like particles (VLPs) that are physically and morphologically similar to NiV. (nih.gov)
  • Immunoblotting confirmed the expression of fusion proteins in gametocytes with the expected mobility for RBX1-HA and SKP1-HA, but no signal above the background could be observed for CUL1-HA. (pberghei.eu)
  • We identified in NiV M a sequence, YMYL, with similarity to the YPDL late domain found in the equine infectious anemia virus Gag protein. (nih.gov)
  • HN - 2006(1981) BX - Actin-Capping Proteins MH - Actin Depolymerizing Factors UI - D051339 MN - D5.750.78.730.212 MN - D12.776.220.525.212 MS - A family of low MOLECULAR WEIGHT actin-binding proteins found throughout eukaryotes. (nih.gov)
  • These results suggest that the YMYL sequence may act as a trafficking signal and a late domain for NiV M. (nih.gov)
  • Genome mining in Plasmodium identified SKP1 , Cullin1, and RBX1 together with two F-box domain-containing proteins. (pberghei.eu)
  • It is expressed at higher levels than ARP2 PROTEIN and does not contain a PROFILIN binding domain. (nih.gov)
  • Coexpression of both proteins seemed to have a slight cooperative effect on the PKB/PDK1-dependent eye phenotype with respect to ommatidial structure. (sdbonline.org)
  • We also find that like growth factor-1 (IGF-1) has a key role in the regulation of MG53 protein level is not upregulated in the muscle samples skeletal muscle size. (marysfamilymedicine.org)