• These effects of the compounds were associated with inhibition of tyrosine phosphorylation and the mitogen-activated protein kinase pathway. (nih.gov)
  • CAAX peptidomimetic FTI-244 decreases platelet-derived growth factor receptor tyrosine phosphorylation levels and inhibits stimulation of phosphatidylinositol 3-kinase but not mitogen-activated protein kinase. (nyu.edu)
  • These events are influenced by and activate other molecular pathways, including phosphatidylinositol 3-kinase (PI3K), mammalian target of rapamycin (mTOR), and mitogen-activated protein kinase (MAPK),[2] and therapies are now available that target these pathocellular processes. (cancernetwork.com)
  • PDGF-β binding to the PDGF receptor-β results in receptor tyrosine kinase domain activation and consequent stimulation of intracellular signaling pathways, including p38 mitogen-activated protein kinase, phosphatidylinositol-3-kinase, Rho-associated protein kinase, and extracellular regulated kinase 1 and 2. (houstonmethodist.org)
  • NIH-3T3 cells treated with the highly specific FTase inhibitor FTI-277 had no effect on PDGF receptor tyrosine phosphorylation or PDGF activation of mitogen-activated protein kinase (MAPK) at doses that completely inhibit FTase-dependent processing. (nyu.edu)
  • Johan Lennartsson's research focuses on platelet-derived growth factor receptor (PDGFR) and mitogen-activated protein kinase (MAPK) signaling in normal physiology and cancer. (onclive.com)
  • Mast Cell and its triggering factors, their corresponding receptors (if those are present), activation pathways and degranulation products. (encyclopedia.pub)
  • These genetic aberrations lead to constitutive activation of these growth factor receptors and concomitant abnormal cellular proliferation, which leads to the development of GIST. (biomedcentral.com)
  • This study gives insight into the interactions between PDGFRβ and Abl2 in the context of Abl2 regulation, and also provide a framework to better understand how growth factor receptors can engage with and regulate Abl family kinases through multistep phosphorylation events. (yale.edu)
  • c-Src can be activated by many transmembrane proteins that include: adhesion receptors, receptor tyrosine kinases, G-protein coupled receptors and cytokine receptors. (wikipedia.org)
  • In the case of growth factor receptors such as the epidermal growth factor (EGF) receptor and platelet-derived growth factor (PDGF) receptor, the kinase must be first activated by ligand. (docksci.com)
  • BACKGROUND: Studies have been performed on human fresh, liquid-preserved, and cryopreserved platelets (PLTs) to assess PLT-adhesive surface receptors, PLT membrane procoagulant activity, PLT aggregation, and thromboxane production. (umassmed.edu)
  • Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. (lookformedical.com)
  • Drugs that selectively bind to and activate beta-adrenergic receptors. (lookformedical.com)
  • There are five different isoforms of PDGF that activate through two different receptors (alpha and beta). (creativebiomart.net)
  • It has become clear that a large number of tumors have aberrant expression of receptor tyrosine kinases, and that this class of cell surface receptors frequently regulates functions such as proliferation, migration, and survival-functions that are deregulated in tumor cells. (onclive.com)
  • Therefore, these receptors have been used as targets for drug development, including low-molecular-weight kinase inhibitors (eg, the clinically used drug Gleevec), but other possibilities are neutralizing antibodies against the receptor (similar to the HER2-targeting antibody Herceptin) or ligand (similar to the vascular endothelial growth factor-targeting antibody Avastin). (onclive.com)
  • EGF (epidermal growth factor), TNF‐α, and PDGF (platelet‐derived growth factor) act through tyrosine kinase receptors and are partially transduced by intracellular reactive oxidant species (ROS) 95. (comprehensivephysiology.com)
  • Pursuing binding, the RTKs dimerize and go through autophosphorylation, initiating some downstream events resulting in proliferation migration and cell success.8 The growth factor VEGF activates angiogenesis by binding to a family group of VEGF receptors, Rabbit Polyclonal to ATP5I including VEGFR-2 (KDR), VEGFR-1 (Flt-1), and VEGFR-3 (Flt-4). (thetechnoant.info)
  • Likewise PDGF binds towards the category of PDGF receptors, Flt-3 (FMS-like tyrosine kinase-3), PDGFRsignaling. (thetechnoant.info)
  • Every monomer contains particular binding domains that provide them the capacity to interact and bind other proteins specifically, factor VIII, collagen, and some platelet receptors. (medscape.com)
  • The signaling pathways activated by the oncogenic mutants are in part overlapping with those normally activated by these receptors, but there are also signal transduction pathways that are unique to the oncogenic mutants. (lu.se)
  • Platelet-derived growth factor (PDGF)-BB has been identified as important factor in pathogenesis of Graves' ophthalmopathy (GO). (eur.nl)
  • Platelet-derived growth factor (PDGF)-β levels rise following SAH and correlate with incidence and severity of vasospasm. (houstonmethodist.org)
  • Results: Release of blood under high pressure into the subarachnoid space activates the complement cascade, which results in release of PDGF. (houstonmethodist.org)
  • The product is produced by recombinant DNA technology by insertion of the gene for the B chain of platelet derived growth factor (PDGF) into the yeast, Saccharomyces cerevisiae. (creativebiomart.net)
  • Binds to the beta platelet-derived growth factor (PDGF) receptor, a tyrosine kinase receptor. (creativebiomart.net)
  • PDGF is known to exist as a dimer, and activates its signaling pathway by a ligand induced receptor dimerization and autophosphorylation. (creativebiomart.net)
  • We have used specific inhibitors for farnesyltransferase (FTase) and geranylgeranyltransferase (GGTase) I as well as combinations of lovastatin with geranylgeraniol (GGOH) or farnesol (FOH) to investigate the role of protein prenylation in platelet-derived growth factor (PDGF)-induced PDGF receptor tyrosine phosphorylation. (nyu.edu)
  • Furthermore, although lovastatin, which inhibits both protein geranylgeranylation and protein farnesylation, blocked PDGF receptor tyrosine phosphorylation, co-treatment with GGOH, but not FOH, reversed the lovastatin block. (nyu.edu)
  • Thus, these results demonstrate that PDGF receptor tyrosine phosphorylation requires protein geranylgeranylation but not protein farnesylation and that the tyrosine phosphorylation levels of the receptor are modulated by a protein that is a substrate for GGTase I. (nyu.edu)
  • Other growth factors involved in vascular remodeling include platelet‐derived growth factor (PDGF), epithelial growth factor (EGF), and fibroblast growth factor (FGF‐2). (comprehensivephysiology.com)
  • a tumor develops in proportions, it becomes progressively hypoxic and causes the discharge of development factors, especially, vascular endothelial development element (VEGF), epidermal development element (EGF), and platelet produced development factor (PDGF) amongst others. (thetechnoant.info)
  • We have previously identified a novel complex between the platelet-derived growth factor (PDGF)β receptor and the sphingosine 1-phosphate receptor-1 (S1P1). (strath.ac.uk)
  • Therefore, an inverse agonist of the S1P1 receptor is predicted to reduce signal transduction from PDGFβ receptor tyrosine kinase by blocking the constitutive activity of the G-protein coupled receptor. (strath.ac.uk)
  • ODIN has been identified as one of the tyrosine phosphorylated proteins induced by activating epidermal growth factor or platelet-derived growth factor receptor tyrosine kinases. (wikipedia.org)
  • Additional proteins previously reported as substrates of other tyrosine kinases were also detected, including ODIN. (wikipedia.org)
  • Furthermore, it has been found that ODIN regulates COPII-mediated anterograde transport of receptor tyrosine kinases, which is a critical mechanism in the process of tumor genesis. (wikipedia.org)
  • Involvement of protein tyrosine kinases in activation of human eosinophils by platelet-activating factor. (uchicago.edu)
  • The Abl family kinases are nonreceptor tyrosine kinases which regular a variety of cellular activities such as cytoskeleton organization and adhesion. (yale.edu)
  • One player in the regulation of Abl family kinases is the platelet-derived growth factor receptor beta (PDGFRβ) which is vital for cell proliferation and chemotaxis, but the molecular mechanism in which PDGFRβ engages in to activate Abl family kinases was previously unknown. (yale.edu)
  • c-Src phosphorylates specific tyrosine residues in other tyrosine kinases. (wikipedia.org)
  • Most studies have looked at the receptor tyrosine kinases and examples of these are platelet derived growth factor receptor (PDGFR) pathway and epidermal growth factor receptor (EGFR). (wikipedia.org)
  • Introduction The mechanism by which tyrosine kinases exert their effects is not well understood. (docksci.com)
  • The results of a detailed analysis of cell signaling in the neuroblastoma cell lines revealed that TKIs inhibited the phosphorylation of the corresponding receptor tyrosine kinases, and thiosemicarbazones downregulated the expression of epidermal growth factor receptor, platelet-derived growth factor receptor, and insulin-like growth factor-1 receptor, leading to a strong induction of apoptosis. (muni.cz)
  • The development elements activate adjacent arteries resulting in angiogenesis.5,6 Pursuing angiogenesis, the tumor can develop at an elevated price.7 For angiogenesis that occurs, the pro-angiogenic development factors need to bind to users of the proteins kinase family defined as receptor tyrosine kinases (RTKs). (thetechnoant.info)
  • The receptor tyrosine kinases KIT and FLT3 are both important regulators of development and maintenance of a number of different cell types. (lu.se)
  • Deregulation of these tyrosine kinases by mutations has been implicated in various human malignancies, including leukemia and melanoma. (lu.se)
  • GISTs result from mutations in receptor tyrosine kinases. (msdmanuals.com)
  • The data provide a rationale for clinical evaluation of these tyrosine kinase inhibitors in AML. (nih.gov)
  • Activated drosophila ras1 is selectively suppressed by isoprenyl transferase inhibitors. (nyu.edu)
  • Although PDGFRB fusions are rare, their identification is important in order to identify patients in whom targeted therapy with tyrosine kinase inhibitors is likely to be successful. (atlasgeneticsoncology.org)
  • Due to the comprehensive inter- and intralesional heterogeneity of level of resistance mutations within specific patients it's been recommended that tyrosine kinase inhibitors (TKI) are improbable to possess curative potential within this disease (2). (academicediting.org)
  • Growth factors such as fibroblast growth factor (FGF), vascular endothelial cell growth factor (VEGF), and angiopoietin-1 (Ang1) are upregulated to stimulate angiogenesis, while downregulation of endogenous protein inhibitors (thrombospondin 1 and interferon) disrupts the balance of physiologic angiogenesis. (cancernetwork.com)
  • Isoproterenol-induced hyperpolarization was inhibited by high-K(+) solution and glibenclamide (10(-6) mol/L), an inhibitor of ATP-sensitive K(+) channels (K(ATP)), but not by apamin, iberiotoxin, or charybdotoxin, inhibitors of Ca(2+)-activated K(+) channels. (lookformedical.com)
  • Comparative activity against c-KIT and FLT3, and myelosuppressive activity of tyrosine kinase inhibitors. (forumbcn2004.org)
  • Tyrosine kinase inhibitors (TKIs) are frequently used in combined therapy to enhance treatment efficacy and overcome drug resistance. (muni.cz)
  • There are a variety of tyrosine kinase inhibitors (TKIs) that are used in oncology for the treatment of malignancies now and consequently there have been increased observations of tumour lysis syndrome (TLS) associated with these drugs. (touchoncology.com)
  • Tyrosine kinase inhibitors (TKIs) are small anticancer molecules targeting protooncogenic tyrosine kinase signalling pathways. (touchoncology.com)
  • With the purpose of developing multitargeted receptor tyrosine kinase inhibitors that display potent inhibition against PDGFRand VEGFR-2 we designed and synthesized eleven and VEGFR-2. (thetechnoant.info)
  • a DNA intercalating dye proven to give a linear approximation of cellular number.35 With this assay, purified angiogenic growth factors sit locally on the vascularized membrane of the developing chicken embryo along with possible inhibitors. (thetechnoant.info)
  • In acute myeloid leukemia (AML), receptor tyrosine kinase ligands promote growth and survival and contribute to AML-associated marrow neoangiogenesis. (nih.gov)
  • discoidin domain receptor tyrosine kin. (gsea-msigdb.org)
  • Research into the oncogenic mechanisms of GISTs has found that these tumors frequently contain activating gene mutations in either platelet-derived growth factor receptor A ( PDGFRA ) or a receptor tyrosine protein associated with a mast cell growth factor receptor encoded by the KIT gene. (biomedcentral.com)
  • GISTs are characterized by mutations in a receptor tyrosine protein (encoded by the KIT gene) associated with a mast cell growth factor receptor or in the gene encoding platelet-derived growth factor receptor A ( PDGFRA ). (biomedcentral.com)
  • Mutations in KIT or the receptor tyrosine kinase PDGFRA are the hallmarks of molecular diagnosis of GIST. (biomedcentral.com)
  • pronounced "sarc", as it is short for sarcoma), is a non-receptor tyrosine kinase protein that in humans is encoded by the SRC gene. (wikipedia.org)
  • In contrast, treatment of these cells with GGTase I inhibitor GGTI-298 strongly inhibited receptor tyrosine phosphorylation, and co-treatment with FTI-277 had no additional effect. (nyu.edu)
  • Further investigations indicated that inhibition of receptor tyrosine phosphorylation was not due to decreased expression of the receptor or to inhibition of GGTase II. (nyu.edu)
  • Vascular endothelial growth factor (VEGF) acts through its receptor KDR, a receptor tyrosine kinase 85. (comprehensivephysiology.com)
  • These findings are the first to report that a GPCR inverse-agonist reduces growth factor-induced receptor tyrosine kinase signaling, fundamentally broadening their mechanism of action. (strath.ac.uk)
  • ODIN is known to regulate the epidermal growth factor receptor (EGFR) and EphA receptor signaling pathways. (wikipedia.org)
  • Platelet activation pathways. (medscape.com)
  • Thereafter, the downstream signaling pathways are activated promoting cell proliferation and/or survival. (biomedcentral.com)
  • Once PDGFB binds to PDGFR-beta, it activates the receptor and initiates a cascade of downstream intracellular signaling pathways, including the PI3K-Akt pathway, MAPK pathway and JAK-STAT pathway. (creativebiomart.net)
  • When a ligand attaches (binds), the KIT or PDGFRA receptor protein is turned on (activated), which leads to activation of a series of proteins in multiple signaling pathways. (medlineplus.gov)
  • As a result, the proteins and the signaling pathways are constantly turned on (constitutively activated), which increases the proliferation and survival of cells and leads to the formation of tumors. (medlineplus.gov)
  • Schematic inflammatory pathways involving growth factors, vasomodulators, and infectious stimuli in the pathogenesis of pulmonary arterial hypertension. (comprehensivephysiology.com)
  • The platelet GP IIb/IIIa complex mediates platelet-to-platelet interactions (platelet aggregation). (medscape.com)
  • Born,G.V. and Cross,M.J. (1963): The Aggregation of Blood Platelets. (9dok.net)
  • The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. (thermofisher.com)
  • TR1-41 induces platelet aggregation. (umassmed.edu)
  • STUDY DESIGN AND METHODS: In both human and baboon fresh and lyophilized PLTs, aggregation response and PLT production of thromboxane A2 were measured after stimulation, and PLT surface markers P-selectin, glycoprotein (GP) Ib, GPIIb-IIIa, and factor (F) V were measured before and after stimulation. (umassmed.edu)
  • PDGFRA activating mutations in gastrointestinal stromal tumors. (msdmanuals.com)
  • Chromosomal translocations involving chromosome bands 5q31-33 that contain the gene encoding the platelet-derived growth factor beta receptor (PDGFRB) are associated with a significant minority of patients with BCR/ABL1-negative chronic myeloid neoplasms. (atlasgeneticsoncology.org)
  • Protein kinase C inhibition enhances platelet-activating factor-induced eicosanoid production in human eosinophils. (uchicago.edu)
  • We have tested simultaneous inhibition of vascular endothelial growth factor, fibroblast growth factor, and platelet-derived growth factor receptor signaling by novel indolinone derivatives using 14 myeloid, including 11 human leukemic, cell lines. (nih.gov)
  • This inhibition is likely through direct binding, as demonstrated by specific and selective interaction between N-ter and activated Gaq in vitro binding assays and co-immunoprecipitation studies. (open.ac.uk)
  • Non-activated Abl2 are kept inactive through an autoinhibitory mechanism involving intramolecular interactions with the Src homology 3 (SH3) and Src homology 2 (SH2) domains, but it has been proposed that interactions with cellular binding partners relieve the inhibition. (yale.edu)
  • The hemostatic system consists of platelets, coagulation factors, and the endothelial cells lining the blood vessels. (medscape.com)
  • Under physiological circumstances, the resistance of the endothelial cell lining to interactions with platelets and coagulation factors prevents thrombosis. (medscape.com)
  • Bombeli,T., Schwartz,B.R., and Harlan,J.M. (1998): Adhesion of Activated Platelets to Endothelial Cells: Evidence for a GPIIb/IIIa-dependent Bridging Mechanism and Novel Roles for Endothelial Intercellular Adhesion Molecule 1 (ICAM-1), α V β 3 -Integrin and GPIbα. (9dok.net)
  • Most of the anti-angiogenic agents approved for cancer treatment rely on targeting vascular endothelial growth factor (VEGF) actions, as VEGF signaling is considered the main angiogenesis promotor. (mdpi.com)
  • The forkhead box (FOX) and ETS transcription factor families have been shown to be important in endothelial specification and establishment. (beckman.com)
  • 4 In addition, vascular endothelial growth factor (VEGF) is an angiogenic factor that regulates endothelial survival, proliferation, differentiation, and vascular permeability, and has been shown to be an important candidate for cancer therapy as it is upregulated in many tumors. (beckman.com)
  • ABSTRACT We evaluated the prognostic value of serum endostatin and vascular endothelial growth factor (VEGF) for diagnosis of pre-eclampsia. (who.int)
  • In response to various stimuli, vWF is released from storage granules in platelets and endothelial cells to control bleeding. (medscape.com)
  • Wogonin (30 mg/kg) also prevented lipopolysaccharide\induced acute lung injury and swelling in mice peroxisome proliferator\activated receptor gamma\mediated attenuation of NF\B pathway 20. (findadig.com)
  • May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. (cusabio.com)
  • In particular, GRK2 tyrosine-phosphorylation, mediated by c-Src, increases GRK2 affinity for Gaq, reinforcing the desensitisation pathway. (open.ac.uk)
  • This experiment revealed that mutations of four specific tyrosines in Abl2 (Y116, Y161, Y272, and Y310) compromise the PDGFRβ-mediated activation of Abl2 which suggests these sites are crucial for proper Abl2 activation. (yale.edu)
  • Finally, patients with certain subtypes of malignant melanoma carry activating mutations in KIT that is driving the disease. (lu.se)
  • Wogonin induces Erk phosphorylation 13 and activates p38MAPK 14 to result in apoptosis of tumour cells. (findadig.com)
  • This induces long-range allostery via protein domain dynamics, causing the structure to be destabilized, resulting in the opening up of the SH3, SH2 and kinase domains and the autophosphorylation of the residue tyrosine 416. (wikipedia.org)
  • Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. (cusabio.com)
  • Poor prognostic factors include older age, male sex, and larger tumor size. (logicalimages.com)
  • Imatinib, a selective tyrosine kinase inhibitor, has been used as a standard first-line therapy for irresectable and metastasized gastrointestinal stromal tumor (GIST) patients. (biomedcentral.com)
  • This initial interaction (platelet adhesion) sets the stage for other adhesive reactions that allow the platelets to interact with other agonists in the vicinity of vessel injury, such as adenosine 5'-diphosphate (ADP), subendothelial collagen, and thrombin. (medscape.com)
  • The body's reaction to vessel wall injury is rapid adhesion of platelets to the subendothelium. (medscape.com)
  • Chen,M. and Geng,J.G. (2006): P-Selectin mediates adhesion of leukocytes, platelets and cancer cells in inflammation, thrombosis, cancer growth and metastasis. (9dok.net)
  • After establishing the sites phosphorylated by PDGFRβ, they show in vitro that the PDGFRβ-mediated phosphorylation activates the Abl2 kinase activity. (yale.edu)
  • Although tyrosine-specific protein kinase activity was described more than 10 years ago, the relevant substrates that mediate the effects of tyrosine phosphorylation have been elusive. (docksci.com)
  • Platelets play a primary role in this process, interacting with subendothelium-bound von Willebrand factor (vWf) via the membrane glycoprotein (GP) Ib complex. (medscape.com)
  • In addition, when platelets are activated, negatively charged phospholipids move from the inner to the outer leaflet of the membrane bilayer. (medscape.com)
  • VEGF as an angiogenic growth factor and 20 weeks of pregnancy. (who.int)
  • Adipogenesis was determined by Oil-Red-O staining, triglyceride measurement, and peroxisome proliferator-activated receptor (PPAR)-c mRNA expression. (eur.nl)
  • Adipogenesis was determined by Oil-Red-O staining, triglyceride measurement, and peroxisome proliferator-activated receptor (PPAR)-γ mRNA expression. (eyehospital.nl)
  • Evidence for platelet-activating factor secretion during immune activation in dogs. (uchicago.edu)
  • Peptides corresponding to the new amino terminal end of the proteolyzed seven-transmembrane domain thrombin receptor [TR42-55, SFLLRNPNDKYEPF, also known as TRAP (thrombin receptor-activating peptide)], previously have been demonstrated to activate the receptor. (umassmed.edu)
  • c-Fms-IN-8 (compound 4a) is a colony stimulating factor-1 receptor (CSF-1R, c-FMS) Type II inhibitor, with an IC50 of 9.1 nM. (adooq.com)
  • c-Fms-IN-10 is the derivative of thieno [3,2-d] pyrimidine, an kinase inhibitor of FMS (Colony stimulating factor-1 receptor, CSF-1R) with IC50 of 2 nM. (adooq.com)
  • EGFR offers been shown to be always a factor in the entire success of A431 cells.26 Cell-proliferation was measured using CYQUANT? (thetechnoant.info)
  • In summary, the cleaved peptide of the seven-transmembrane domain TR (TR1-41) is a strong platelet agonist. (umassmed.edu)
  • Platelet-derived growth factor-BB enhances adipogenesis in orbital fibroblasts, and, thus, may contribute to adipose tissue expansion in GO. (eur.nl)
  • Four metabolites affected in both groups included glycolithocholic acid, and three different long-chain (C18) phospholipid molecules (phosphatidylethanolamine, platelet activating factor (PAF), and monoacylglycerol). (asoi.info)
  • Platelet-derived growth factor B, commonly known as PDGFB, plays an important role in various biological processes and its dysregulation has been associated with several pathological conditions. (creativebiomart.net)
  • This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. (thermofisher.com)
  • Marked upregulation of the metastasis suppressor N-myc downstream regulated gene-1 (NDRG1), which is known to be activated and upregulated by thiosemicarbazones in adult cancers, was also detected in thiosemicarbazone-treated neuroblastoma cells. (muni.cz)
  • Bom,V.J. and Bertina,R.M. (1990): The contributions of Ca 2+ , phospholipids and tissue-factor apoprotein to the activation of human blood-coagulation factor X by activated factor VII. (9dok.net)
  • The activation of c-Src causes the dephosphorylation of the tyrosine 527. (wikipedia.org)
  • Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. (thermofisher.com)
  • TR1-41-induced platelet activation was synergistic with TR42-55. (umassmed.edu)
  • Circulating monocyte-platelet aggregates appear to be a more sensitive marker of in vivo platelet activation than circulating P-selectin-positive platelets. (umassmed.edu)
  • The activation loop tyrosine 823 is essential for the transforming capacity of the c-Kit oncogenic mutant D816V. (lu.se)
  • The initial hemostatic plug, composed primarily of platelets, is stabilized further by a fibrin mesh generated in secondary hemostasis. (medscape.com)
  • 2006): The influence of fibrin polymerization and platelet-mediated contractile forces on citrated whole blood thromboelastography profile. (9dok.net)
  • The platelets arise from the fragmentation of the cytoplasm of megakaryocytes in the bone marrow and circulate in blood as disc-shaped anucleate particles for 7-10 days. (medscape.com)
  • Bentfeld-Barker,M.E. and Bainton,D.F. (1982): Identification of primary lysosomes in human megakaryocytes and platelets. (9dok.net)
  • Breton-Gorius,J. and Guichard,J. (1972): Ultrastructural localization of peroxidase activity in human platelets and megakaryocytes. (9dok.net)
  • von Willebrand factor (vWF) is a large multimeric glycoprotein synthesized as a 2050 amino acid monomer in endothelium, megakaryocytes, and the subendothelial connective tissue. (medscape.com)
  • This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. (thermofisher.com)
  • As platelet-activating factor and HPC share structural semblances and both induce killing of intracellular Leishmania , we surmised that platelet-activating factor (PAF) receptor had a significant role in the antileishmanial function of miltefosine. (aai.org)
  • general transcription factor IIH subun. (gsea-msigdb.org)
  • general transcription factor IIIC subu. (gsea-msigdb.org)
  • Given the functional relation between KIT and the transcription factor MITF, we are investigating the molecular mechanisms behind the KIT-mediated regulation of MITF. (lu.se)
  • It also regulates angiogenic factors and vascular permeability after focal cerebral ischemia-reperfusion, and regulates matrix metalloproteinase-9 activity after intracerebral hemorrhage. (wikipedia.org)