Typically gene expression environmental exposure. Medical search. Frequent questions

So, there is diversity in the expression of various proteins inside the cell and that makes them different. (udel.edu)
Using single-cell measurements on the level of proteins and messenger RNA molecules that provide cells instructions to survive, combined with modeling of complex regulatory gene networks, we want to uncover mechanisms that drive interconversion between cell states. (udel.edu)
Does the transgenic approach employ induce alteration of the level of expression of the proteins that exist in the host crop? (gmo-safety.eu)
We focused on the epigenome, the part of the genome that doesn't code for proteins but governs gene expression," Lazar said. (sciencedaily.com)
Diet-induced epigenomic changes in fat cells occur at histones -- proteins that package and order DNA in the nucleus, which influences gene expression -- across the genome. (sciencedaily.com)
One of the most prominent stimuli of asthma, environmental things, can bring about damage to certain chain-complex proteins, sustaining ROS generation, and may further bring about airway hyperresponsiveness (AHR) (85, 86). (namptinhibitor.com)
Instead, it involves modifications to the structure of DNA and associated proteins, which can silence or activate genes. (alliedacademies.org)
These RNA molecules, such as microRNAs and long non-coding RNAs, can regulate gene expression in animals by interacting with DNA, RNA, and proteins. (cbtdogbehaviour.com)
These genes make mRNA that makes proteins that make cells, including networks of nerve cells in our brains. (scienceinschool.org)
Gene expression refers to how often or when proteins are created from the instructions within your genes. (cdc.gov)
Typically, this group is added to specific places on the DNA, where it blocks the proteins that attach to DNA to "read" the gene. (cdc.gov)
When histones are tightly packed together, proteins that 'read' the gene cannot access the DNA as easily, so the gene is turned "off. (cdc.gov)
When histones are loosely packed, more DNA is exposed or not wrapped around a histone and can be accessed by proteins that 'read' the gene, so the gene is turned "on. (cdc.gov)
Non-coding RNA helps control gene expression by attaching to coding RNA, along with certain proteins, to break down the coding RNA so that it cannot be used to make proteins. (cdc.gov)
Non-coding RNA may also recruit proteins to modify histones to turn genes "on" or "off. (cdc.gov)
Epigenetics allows the muscle cell to turn "on" genes to make proteins important for its job and turn "off" genes important for a nerve cell's job. (cdc.gov)
Ceramide is a pro-apoptotic lipid that regulates stress proteins and genes within the endoplasmic reticulum. (livewellva.net)

The results of toxicity testing suggested that exposure to aged PS-NPs caused a more severe decrease in brood size, egg ejection rate, number of fertilized eggs, and hatchability than did the virgin PS-NPs in the P0, F1, and F2 generations. (bvsalud.org)
Overall, maternal exposure to aged PS-NPs induced transgenerational reproductive effects via H3K4 and H3K9 methylation, and the spr-5, met-2, and set-17 genes were involved in the regulation of transgenerational toxicity. (bvsalud.org)
For example, nickel nanoparticles (NiNPs) are used in electric capacitors, and their consumption is increasing, but there have been few reports of their toxicity and environmental effects. (go.jp)
Returning NCSA Faculty Fellow Madak-Erdogan aims to develop a machine learning approach for early prediction of mammalian toxicity of small molecules using gene expression data, specifically to identify early biomarkers of liver cancer due to liver toxicant exposure, a critical problem at the intersection of the agriculture industry and human health today. (illinois.edu)
Risk factors for breast cancer include synthetic hormone replacement therapies, hormonal imbalances, and reproductive factors including age when given birth and if the infant was breast fed, family history of breast cancer, age cancer was acquired and other factors including radiation exposure to electromagnetic fields, viruses (Jadack, 2013) and environmental toxicity which interferes with endocrine function. (livewellva.net)
My research focuses on fish and other aquatic invertebrates and has ranged from investigating the mechanisms of toxicity of environmental chemicals using (epi)genomics approaches to understanding disease susceptibility within aquaculture. (exeter.ac.uk)

Acute lymphoblastic leukemia emerges when a single lymphoblast gains many mutations to genes that affect blood cell development and proliferation. (wikipedia.org)
These genes, in turn, increase the risk that more mutations will occur in developing lymphoid cells. (wikipedia.org)
Environmental risk factors are also needed to help create enough genetic mutations to cause disease. (wikipedia.org)
[ 3 ] Although mutations in FRAS1 or FREM2 genes appear in half of Fraser syndrome cases, the syndrome's expression can vary significantly among individuals. (medscape.com)
Defects in processes that modulate cell division, such as mutations in genes that participate in DNA repair, uncorrected errors during replication, or broken, missing, rearranged, or extra chromosomes, are the principal drivers of genomic instability. (foundmyfitness.com)
Cancer is a disorder of gene expression resulting in genetic mutations which alter a normal cell and transform it by numerous ways to a cancer cell. (livewellva.net)

Increased levels of H3K4 and H3K9 methylation were observed in the F1 and F2 generations, which were concomitant with the transgenerational downregulation of the expression of associated genes, such as spr-5, set-17, and met-2. (bvsalud.org)
On the basis of correlation analyses, the levels of histone methylation and the expression of these genes were significantly correlated to transgenerational reproductive effects. (bvsalud.org)
Moreover, malnutrition, high-fat diets and environmental toxicant exposure of ancestral generation lead to DNA methylation, which results in altered phenotypes of adipocyte metabolism and function. (biocertica.com)
However, there is much research that shows a direct correlation between prenatal alcohol exposure, altered DNA methylation in maternal and paternal lines, and FAS. (biocertica.com)
Epigenetic mechanisms include DNA methylation, histone modifications, and non-coding RNA molecules, all of which contribute to the regulation of gene expression. (alliedacademies.org)
DNA methylation involves the addition of a methyl group (CH3) to cytosine residues in DNA, typically at CpG dinucleotides. (alliedacademies.org)
In the context of adipogenesis, DNA methylation patterns are dynamically regulated, leading to changes in gene expression that impact fat cell development[ 1 ]. (alliedacademies.org)
Studies have shown that changes in DNA methylation patterns can affect the expression of genes involved in adipocyte differentiation and lipid metabolism. (alliedacademies.org)
Methylation can prevent the binding of transcription factors and inhibit gene expression. (cbtdogbehaviour.com)
Environmental factors can influence the pattern of DNA methylation in animals, leading to variations in gene expression and behaviour. (cbtdogbehaviour.com)
They can be chemically modified through processes such as acetylation and methylation, which can influence gene expression by altering the accessibility of DNA to transcription machinery. (cbtdogbehaviour.com)
Typically, methylation turns genes "off" and demethylation turns genes "on. (cdc.gov)
For example, at certain parts of the AHRR gene, smokers tend to have less DNA methylation than non-smokers. (cdc.gov)
After quitting smoking, former smokers can begin to have increased DNA methylation at this gene. (cdc.gov)
In 2009, Yehuda and Bierer posited that epigenetic modifications, such as DNA methylation, may occur in response to environmental influences such as trauma exposure, thus altering the functional expression of genes. (cdc.gov)

Epigenetics refers to the heritable changes in gene expression that do not involve alterations to the DNA sequence itself. (alliedacademies.org)
Epigenetics is a rapidly growing field that investigates heritable changes in gene function that do not involve alterations in the DNA sequence itself. (cbtdogbehaviour.com)

Individuals affected with PTSD (Post-Traumatic Stress Disorder) demonstrate changes in microRNA (miRNA) molecules associated with gene regulation. (news-medical.net)
This article explores the fascinating world of epigenetic regulation in the context of obesity, shedding light on how environmental factors can influence gene expression, ultimately impacting our weight and overall health. (alliedacademies.org)
In the hypothalamus, histone modifications have been linked to the regulation of genes involved in appetite control and energy homeostasis. (alliedacademies.org)
For example, histone acetylation of genes encoding neuropeptides like leptin and ghrelin, which play critical roles in appetite regulation, can affect their expression. (alliedacademies.org)
Epigenetic gene regulation is a proposed mechanism by which early life exposures affect later health outcomes. (biomedcentral.com)
Gene regulation by steroid hormones plays important roles in health and disease. (sdbonline.org)
The light source is a crucial environmental cue that plays an important role in the regulation of circadian rhythms. (keydifference.in)

Altered histone acetylation patterns in response to dietary changes or environmental factors can disrupt the balance between appetite-stimulating and appetite-suppressing signals, potentially contributing to overeating and obesity[ 2 ]. (alliedacademies.org)

Does thiamine influence gene expression? (betterhealthguy.com)

However, they have very important roles in biology (every miRNA regulates the expression, and thereby also the activity of several other genes), and they are known to regulate the impact of environmental factors on biology. (news-medical.net)
Similarly, exposure to asbestos fibers both in vitro and in vivo leads to improved mtROS production, which regulates lung epithelial cell apoptosis and fibrosis (82, 83). (namptinhibitor.com)
Vitamin D is obviously the most well-known one that regulates over 2,000 genes related to immune health, musculoskeletal health and many other things. (truthseekerforum.com)

Here we used a mouse (C57BL/6) model of environmental pollutant exposure by administration of a particulate matter (SRM1649b at 300 μg/day/mouse) suspension intra-nasally beginning 2 months before conception and during gestation, in comparison to saline-exposed controls. (nature.com)
There is probably no single one chemical exposure responsible for these illnesses, but more likely a mixed exposure of chemical classes such as particulate matter and oxygenated organic species (oxidized volatile organic compounds that are likely biologically reactive and potentially cause cell damage and increase susceptibility to disease). (cdc.gov)

The differentiation of preadipocytes into mature adipocytes involves a series of epigenetic changes that control the expression of genes responsible for fat storage and metabolism. (alliedacademies.org)
Various environmental factors can induce epigenetic changes in animals, affecting their health, behaviour, and predisposition to diseases. (cbtdogbehaviour.com)
Toxins: Environmental pollutants, such as heavy metals and endocrine disruptors, can induce epigenetic changes in animals, increasing the risk of various health issues, including cancer and neurological disorders. (cbtdogbehaviour.com)
While genetic changes can alter which protein is made, epigenetic changes affect gene expression to turn genes "on" and "off. (cdc.gov)
Since your environment and behaviors, such as diet and exercise, can result in epigenetic changes, it is easy to see the connection between your genes and your behaviors and environment. (cdc.gov)
Epigenetic changes affect gene expression in different ways. (cdc.gov)

Hypermethylation of specific CpG sites in the promoter regions of genes can silence their expression, while hypomethylation can activate gene transcription. (alliedacademies.org)
This study shows that the nucleosome remodeller dMi-2 is recruited to ecdysone-regulated genes to limit transcription. (sdbonline.org)

Consumer products used in indoor environments for cleaning, surface finishing and deodorizing are typically mixtures of many chemicals. (cdc.gov)
Nutrition, exposure to certain chemicals or toxins, and even social interactions can all impact how our bodies develop. (groenerekenkamer.com)
Though the study used this model to directly replicate exposure to PBB153, Greeson says this approach could be used to better understand the impact of other environmental exposures on reproduction, including large-scale accidental exposures to toxic chemicals or everyday exposures. (neurosciencenews.com)
Pollution and exposure to toxic chemicals is associated with a wide range of health effects, and disease linked to pollution were estimated to be responsible for 9 million deaths worldwide in 2015 [ 1 ] . (medrxiv.org)
Exposure to low doses of toxic metals (and other chemicals) is almost ubiquitous amongst the population. (medrxiv.org)
PhD studentship (with the Salmon and Trout Association) - Endocrine disrupting chemicals (EDCs) and the sustainability of brown trout populations in the UK: relative impact of EDCs compared with other environmental stressors. (exeter.ac.uk)

Exposure to PBB153, a chemical component of the now-banned flame retardant FireMaser, causes alterations in the genetic code of sperm, leading to major health and reproductive deficits in the children of parents exposed to the substance. (neurosciencenews.com)
The team looked at the expression of different genes in their human spermatogenesis model after dosing with PBB153 and found marked alterations in gene expression between dosed and undosed cells, specifically at genes important to development, such as embryonic organ, limb, muscle, and nervous system development. (neurosciencenews.com)
Epigenetic alterations in response to toxic exposures - the need to determine effect modification by nutrient status. (cdc.gov)

Diet is a major environmental factor that influences the functioning of the epigenome, and ancestral diet exposure may lead to diseases such as cardiovascular disease, obesity and fetal alcohol syndrome (FAS). (biocertica.com)

The challenge and promise of utilizing epigenetic and biomarker data to explore the impact of prenatal exposures on offspring health are highlighted in a recent publication. (cdc.gov)

Zebrafish exposed to four different concentrations of NiNPs or NiCl 2 for 72 hr or 7 days were subjected to histopathological analysis, and tissue samples were subjected to analyses for oxidative stress and gene expression. (go.jp)
Both metals were able to deregulate genes involved in hormonal control, general stress, and oxidative stress. (sorbonne-universite.fr)
Oxidative stress ErbB4/HER4 Source causes lipid peroxidation, resulting in protein carbonylation, typically known as "carbonyl strain," that's predominantly associated with chronic ailments (76). (namptinhibitor.com)

Some researchers hypothesize that genetic predispositions combined with environmental stressors (eg, virus exposure or birth trauma) result in brain deposition of amyloid and disruption of synaptic transmissions, possibly involving interleukin-1 (IL-1) or beta-endorphins. (medscape.com)
Which environmental stressors may deplete the body of thiamine? (betterhealthguy.com)
I am an environmental biologist investigating how environmental stressors affect living organisms in aquatic systems, both within natural environments and in aquaculture. (exeter.ac.uk)

VDREs also contain the receptors for 1,25(OH)2D and regulate the expression of certain genes. (holtorfmed.com)
Future investigations of miR-34 targets that regulate the expression of EcR-B1 in MB γ neurons are warranted to elucidate pathways that regulate axon pruning, and to provide insight into mechanisms that control large-scale axon degeneration in the nervous system. (sdbonline.org)

In modern electrically lit societies, however, many if not most people suffer some degree of disruption of the circadian rhythms by exposure to light at night and by inadequate exposure to sunlight, especially in the morning. (cdc.gov)
To stay in sync with the external world the circadian rhythms are constantly modified based upon environmental signals and mainly the dark-light cycle. (keydifference.in)

Dramatic improvements have occurred over the past several decades in such areas as reducing infant mortality, reducing mortality and morbidity from many infectious diseases and accidental causes, increasing access to health care, and reducing environmental contaminants, such as lead ( Centers for Disease Control and Prevention, 1999b , 2000a ). (nih.gov)

Environmental risk factors may include significant radiation exposure or prior chemotherapy. (wikipedia.org)
Acute lymphoblastic leukemia is typically treated initially with chemotherapy aimed at bringing about remission. (wikipedia.org)
This is then followed by further chemotherapy typically over a number of years. (wikipedia.org)
For example, when patients undergo chemotherapy for cancer, typically tumor size shrinks as tumor cells die. (udel.edu)
The first-line treatment typically includes chemotherapy combined with immunotherapy, which is a combination of medications that destroy the cancer cells. (rarediseases.org)

In parallel, we evaluated the extended expression pattern of 38 molecular targets used as potential biomarkers of exposure through qPCR. (sorbonne-universite.fr)
The latter is typically defined by physiological biomarkers and risk of adverse health outcomes, including all-cause mortality. (cdc.gov)

Chemical groups can be added or removed from histones to make the histones more tightly or loosely packed, turning genes "off" or "on. (cdc.gov)

As an acute leukemia, ALL progresses rapidly and is typically fatal within weeks or months if left untreated. (wikipedia.org)
Diagnosis is typically Acute lymphoblastic leukemia based on blood tests and bone marrow examination. (wikipedia.org)
Acute exposure to 1 µg/L of NPS-60 (NPS with light irradiation time of 60 d) significantly decreased locomotion behaviors and neurotransmitter contents (e.g., glutamate, serotonin, dopamine, and Î³-aminobutyric acid). (bvsalud.org)
Animal studies indicate that the liver, lungs, and kidneys have the greatest soft-tissue lead concentrations immediately after acute exposure. (medscape.com)

Exposure to environmental pollutants contributes to the development of placental abnormalities, with poorly understood molecular underpinning. (nature.com)
These data indicate that environmental exposure to air pollutants triggers changes in the placental cellular composition, mediating adverse pregnancy outcomes. (nature.com)
This has been due to a number of factors including the previous successes of examining one pollutant at a time, the costs associated with measuring multiple pollutants, and the fact the pollutants are typically highly correlated within individuals, which poses challenges for statistical modelling [ 5 , 6 ] . (medrxiv.org)

however, the concentrations of these metals in various environmental matrices have increased through their intensive use in many human activities (such as industry, mining and agriculture). (sorbonne-universite.fr)
Using the model of the fruit fly Drosophila melanogaster, for which many tools are readily available, we investigated how different concentrations of Cd and Hg in single and combined exposures impact post-embryonic development. (sorbonne-universite.fr)
Average concentrations of lead in the blood of children younger than 5 years dropped 78 percent between 1976-1980 and 1992-1994 ( U.S. Environmental Protection Agency, 2000a ). (nih.gov)

These epimutations (mutation in the expression of the gene, not the DNA sequence) are associated with the transgenerational inheritance of obesity [4]. (biocertica.com)
Importantly, we were only changing the mouse's environment with a drug or temperature, not the actual DNA sequence of the Ucp1 gene," Lazar said. (sciencedaily.com)
The team is following up the mouse studies using human fat biopsies to figure out the exact DNA sequence differences responsible for variable Ucp1 expression, both in mice and in humans. (sciencedaily.com)
A protein consists of one or more chains of amino acids (called polypeptides) whose sequence is encoded in a gene. (genome.gov)
Epigenetics in animals is a field that explores how environmental factors, such as diet, stress, and toxins, affect gene expression in animals without altering the DNA sequence. (cbtdogbehaviour.com)

Since epigenetics is the overlap between nature and nurture, environmental influences can affect the onset of disease throughout multiple generations. (biocertica.com)
These studies also emphasise the importance of the age at which an individual is exposed to environmental influences will determine the TEI [1]. (biocertica.com)
[4] Environmental factors include social, cultural and behavioral influences. (wikipedia.org)
In this article, we will discuss what schizophrenia is and what its potential causes are, and then introduce some of our recent research to investigate the combined genetic and environmental influences that can lead to this devastating condition. (scienceinschool.org)

The damage was typically characterized by epithelial degeneration and necrosis in the gills, esophagus, and intestines, as well as by lipid loss and palisade pattern degradation in the liver. (go.jp)
On the other hand, hypomethylation of genes associated with lipid storage and adipocyte development can promote adipogenesis. (alliedacademies.org)

Polystyrene nanoplastics (PS-NPs) are emerging environmental contaminants that are ubiquitously detected in various environments and have toxic effects on various organisms. (bvsalud.org)

Epigenetics is the study of how your behaviors and environment can cause changes that affect the way your genes work. (cdc.gov)

They are able to break free from the constraints of toxic masculinity and explore a wider range of emotions, behaviors, and self-expression. (groenerekenkamer.com)
Current approaches to modeling and learning the temporal dynamics and recurrent behaviors of huge-scale diffusion networks, such as social networks, disease networks, and cyber-crime networks typically lack the flexibility and/or scalability to accommodate ever-growing massive event data. (illinois.edu)
Your genes play an important role in your health, but so do your behaviors and environment, such as what you eat and how physically active you are. (cdc.gov)

A third mechanism of action involves retrograde signaling and the modulation of gene expression. (truthseekerforum.com)

Since the placenta co-exists with the fetus, it also encounters various intra-uterine exposures, and experiences certain detrimental effects, which in turn could negatively impact maintenance of a pregnancy or fetal health 2 . (nature.com)
It has been estimated that indoor environmental quality-related health issues cost businesses in the range of $20-70 billion annually due to lost productivity, decreased performance, and sick absences. (cdc.gov)
Given that these new oxygenated species are not detected by conventional sampling methods, new techniques are needed to assess worker exposure and the potential health risk. (cdc.gov)
This is where the Society of Toxicology comes into play to ensure that they offer maximum protection and enhancement of the human, animal as well as environmental health. (gmo-safety.eu)
A new study from the University of Georgia has shown that exposure to a now-banned flame retardant can alter the genetic code in sperm, leading to major health defects in children of exposed parents. (neurosciencenews.com)
In the decades since, a range of health problems including skin discoloration, headache, dizziness, joint pain and even some cancers have been linked to the exposure. (neurosciencenews.com)
It is still a relatively new idea that a man's exposures prior to conception can impact the health of his children," said Greeson, an environmental health science doctoral student in Charles Easley's lab at UGA's College of Public Health and Regenerative Bioscience Center. (neurosciencenews.com)
PBB153 seems to turn on these genes in sperm which should be turned off," said Greeson, which may explain some of the endocrine-related health issues observed in the children of exposed parents. (neurosciencenews.com)
Aside from my research, I enjoy engaging with the public to increase awareness of women's health, and, when I am not in the lab, you can typically find me outdoors! (wrfseattle.org)
Despite advances in the understanding of the links between chemical exposures and disease at lower exposure levels, our understanding of the health effects of exposure to chemical mixtures has evolved more slowly. (medrxiv.org)
Variation from cell health/exposure to environmental stress. (caltech.edu)
It's a widely accepted assertion that 75 percent of our health and life expectancy after age 40 is determined by environmental factors, including the impact of our daily lifestyle choices. (marksdailyapple.com)
Instead, these changes are driven by environmental factors, such as diet, stress, and exposure to toxins, that can affect gene expression and contribute to various health conditions and behavioural patterns in animals. (cbtdogbehaviour.com)
Stress: Exposure to stress can alter the expression of stress-related genes in animals through epigenetic mechanisms, potentially affecting their behaviour and mental health. (cbtdogbehaviour.com)
There's a mountain of literature showing that regular sun exposure is one of the most powerful and important things you can do for your health and to prevent disease. (truthseekerforum.com)
So I'm the Medical Director of the World Trade Center Environmental Health Center for the survivors and community members, and my background, as you've heard, is really I began as an asthma doctor, asthma and environmental issues were my interest, and I've been at NYU and at Bellevue and at Health + Hospitals for many, many, many years, and I'm now a professor there. (cdc.gov)

Understanding why men possess certain biological traits that are typically associated with femininity can provide valuable insights into the diversity and complexity of human biology. (groenerekenkamer.com)
When relevant genes are identified it is often possible to implicate biological intermediates and pathways likely to be involved in disease aetiology. (prolekarniky.cz)
This study leveraged data from the Multi-Ethnic Study of Atherosclerosis (MESA) on experiences of threat and deprivation in participants' early lives (i.e., before the age of 18) to examine whether exposure to specific dimensions of early life adversity are associated with epigenetic profiles at older ages that are indicative of accelerated biological aging. (cdc.gov)
Although its molecular causes are unclear, its development is thought to involve a range of biological, psychological and environmental factors. (cdc.gov)

However, single genetic variants typically explain small amounts of disease risk. (prolekarniky.cz)
For example, the association between coronary heart disease and genetic variants located within genes regulating levels of low density lipoprotein (LDLc) [1] - [4] , confirms low density cholesterol as a key player in the aetiology of coronary heart disease. (prolekarniky.cz)
Diagnosis is by sweat test or identification of 2 cystic fibrosis-causing gene variants in patients with a positive newborn screening test result or characteristic clinical features. (msdmanuals.com)

EPA must quantify the amount of potential human risk that may be associated with exposure to When establishing national standards for clean air environmental contaminants. (cdc.gov)

Certain teratogenic exposures during early pregnancy (eg, radiation and specific chemical exposure) have been linked to eyelid coloboma with CPA. (medscape.com)
The chemical analysis shows that the methamphetamine that is typically found in St. Louis originates in super labs south of the US border, while the fentanyl seized usually comes from China, before it gets mixed into the other drugs-like heroin-being sold by the cartels. (drug-rehabs.org)
Yet, little work has been done to understand how the chemical exposure could have impacted genes passed from an exposed father, said study author Katherine Greeson. (neurosciencenews.com)

For our ancestors the cycle was kept precisely at 24 hours by the natural cycle of exposure to sunlight. (cdc.gov)
It may be particularly valuable and beneficial for people who aren't getting enough natural sunlight exposure, and that's a majority of people. (truthseekerforum.com)
So, not only do they not get sunlight exposure, but they also get harmful EMF exposure. (truthseekerforum.com)
The absence of that exposure to sunlight creates abnormal cell function. (truthseekerforum.com)

These modifications can either activate or silence genes, ultimately shaping an animal's phenotype, behaviour, and susceptibility to certain disease s. (cbtdogbehaviour.com)

The diminishment of organ reserve and lean muscle mass is somewhat genetically influenced, but as we say here at MDA time and again, the expression of your genes depends on the interaction between your genetic blueprint and your personal environment and lifestyle. (marksdailyapple.com)
The hallmarks mentioned above increase in severity over time for most living organisms, but the rate of declining function depends upon several genetic and environmental factors specific to each individual. (foundmyfitness.com)

The last few years have seen much attention given to whether the modification and expression of genes - epigenetic modifications - might be involved. (news-medical.net)

For instance, hypermethylation of the promoter region of the Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) gene, a master regulator of adipogenesis, can suppress its expression, impairing fat cell formation. (alliedacademies.org)

[ 5 ] Environmental factors, including specific drugs and toxins, have been associated with Goldenhar syndrome's onset. (medscape.com)
Environmental factors: Beyond genetics and hormones, environmental factors also influence the development of feminine traits in men. (groenerekenkamer.com)
In their final experiments, the team asked what happens when browning and Ucp1 expression are activated using rosiglitazone or exposure to cold, both environmental factors. (sciencedaily.com)
Most commonly, fleas are the perpetrator of skin sensitivity from environmental factors. (greenlinpetresorts.com)
Although autoimmune diseases have a genetic component, environmental factors such as vitamin D intake have been shown to have a significant effect on these conditions. (holtorfmed.com)
Overall, we think that asthma is about 50%-60% genetic, meaning that there are both genetic and environmental determinants and risk factors. (medscape.com)

Much of this adaptive imprint is delivered to developing tissues by changes in gene expression and cellular content. (nature.com)

Prevention is the key to managing cadmium exposure. (cdc.gov)
For the general public, the primary source of exposure to cadmium is dietary. (cdc.gov)
Chronic cadmium exposure primarily affects the kidneys and secondarily the bones. (cdc.gov)

The addition of a methyl group to the DNA molecule, typically at a cytosine base. (cbtdogbehaviour.com)

Moreover, genetic and simple obesity share similar structural and functional features of dysbiosis, such as higher production of toxins with known potential to induce metabolic deteriorations (e.g. trimethylamine-N-oxide and indoxyl sulphate), higher abundance of genomes containing genes coding enzymes involved in the production of these toxic co-metabolites and higher abundance of pathways for biosynthesis of bacterial antigens (such as endotoxin) [13-15]. (deepdyve.com)

In contrast, integration of the gill RNA-seq data with the gill histopathology enabled us to identify common gene expression patterns associated with multifactorial gill disease, independently from the origin of samples. (frontiersin.org)

This syndrome typically occurs due to mothers consuming alcohol while pregnant, and children present with physiological, neurobiological and cognitive deficits [5]. (biocertica.com)

Work-related asthma is a subset of occupational lung disease which can be further subdivided into occupational asthma, which can be caused by exposure to a sensitizer or irritant at work, and work-exacerbated asthma, which is when pre-existing asthma becomes worse due to exposures at work. (cdc.gov)

Exploring how embracing feminine traits can psychologically impact men reveals the complexity of gender identity and self-expression. (groenerekenkamer.com)
Oxidants have a direct impact on the production in the most potent fibrogenic cytokine, transforming growth issue b (TGF-b), inducing its gene expression. (namptinhibitor.com)

The isolated coloboma typically occurs sporadically, but some familial instances have been identified. (medscape.com)
Stem cell exhaustion , a phenomenon that occurs as progenitor cells reproduce to give rise to new specialized cells (e.g., skin, liver, cardiac, skeletal muscle cells) but can accelerate due to environmental exposures. (foundmyfitness.com)

This includes insecticides, herbicides, and fungicides commonly used in agriculture that are known to produce broad ranging, off-target effects on beneficial wildlife, even at seemingly non-toxic low dose exposures. (researchgate.net)

Dr. Emily Coderre studies the cognitive neuroscience of language using neuroimaging techniques such as electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) to examine the cognitive processes underlying language in both typically developing populations and in special population such as bilinguals and individuals with autism. (uvm.edu)

Typically, scientific studies are either epidemiological in nature and inherently observational or focus on bench science, but in this study, we did both," said Greeson. (neurosciencenews.com)
Epigenetic data can be particularly difficult to analyze and interpret in nutritional and environmental epidemiological studies. (cdc.gov)

Here, we critically review the literature on this topic as it pertains to the rhizosphere microbiome of crop plants and gut microbiome of pollinator insects (namely managed populations of the western honey bee, Apis mellifera), since both are frequent recipients of chronic pesticide exposure. (researchgate.net)

In childhood ALL, this process begins at conception with the inheritance of some of these genes. (wikipedia.org)

Hopefully this work will lead to more studies combining epidemiology and bench science in the future, which will tell us more about why we're seeing an effect from an environmental exposure in human populations and encourage experimental studies to more closely mimic human exposures," she said. (neurosciencenews.com)

Anatomy10

Organisms8

Diseases27

Chemicals and Drugs72

Analytical, Diagnostic and Therapeutic Techniques and Equipment43

Psychiatry and Psychology1

Phenomena and Processes62

Disciplines and Occupations11

Anthropology, Education, Sociology and Social Phenomena2

Technology, Industry, Agriculture6

Information Science9

Named Groups1

Health Care44

Geographicals8

Proteins17

Toxicity6

Mutations6

Methylation15

Heritable changes in gene2

Regulation7

Histone1

Influence gene expression1

Regulates3

Particulate matter2

Epigenetic changes6

Transcription2

Chemicals6

Alterations3

Epigenome1

Prenatal1

Oxidative stress3

Stressors3

Regulate the expression2

Circadian rhythms2

Centers for Diseas1

Chemotherapy5

Biomarkers2

Histones1

Acute4

Pollutants3

Concentrations3

Sequence5

Influences4

Lipid2

Emerging environmental contaminants1

Epigenetics1

Behaviors3

Mechanism1

Health16

Biological4

Variants3

Contaminants1

Chemical3

Sunlight4

Silence1

Depends2

Modifications1

Promoter1

Factors6

Cellular1

Cadmium3

Cytosine1

Toxins1

Common gene1

Physiological1

Asthma1

Impact2

Occurs2

Dose1

Functional1

Epidemiological2

Chronic1

Conception1

Populations1