CutaneousDiscoidEtiologyAssociated with systemicChronicProfundusSystemic lupusConnectiveSubcutaneous nodulesOrgansSymptomsJointsPrevent lupusPhotosensitivityWorkupInflammatoryCommonlyDiagnosisManifestationMutationSubtypesAntibodiesSyndromeDiseaseSymmetricMedicationImmuneTriggersFrequentRarelyBiopsyCarcinomaPatientsFlaresTypesPartsConditionCellsFeature
Cutaneous11
- Discoid lupus erythematosus is the most common type of chronic cutaneous lupus (CCLE), an autoimmune skin condition on the lupus erythematosus spectrum of illnesses. (wikipedia.org)
- Cutaneous lupus erythematosus (CLE) can be divided into three main subtypes: acute, subacute, and chronic, all of which demonstrate photosensitivity. (medscape.com)
- Acute cutaneous lupus erythematosus (ACLE) most commonly presents as symmetric erythema overlying the malar cheeks and nasal bridge with sparing of the nasolabial folds (butterfly rash). (medscape.com)
- Subacute cutaneous lupus erythematosus (SCLE) characteristically presents as annular or psoriasiform plaques in a photodistribution. (medscape.com)
- Chronic cutaneous lupus erythematosus (CCLE) can be further divided into three main types: discoid lupus erythematosus (DLE), tumid lupus, and lupus panniculitis. (medscape.com)
- In Europe and the United States, the incidence of isolated cutaneous lupus erythematosus (CLE) has ranged from 4 to 4.3 cases per 100,000 population, slightly higher than the incidence of SLE (approximately 3 cases per 100,000 population). (medscape.com)
- Cutaneous lupus erythematosus (CLE) is an interferon (IFN)-driven autoimmune disease that may be limited to the skin or can be associated with systemic lupus erythematosus (SLE). (frontiersin.org)
- Cutaneous lupus erythematosus (CLE) is a heterogeneous autoimmune skin disease that can occur isolated to the skin or with additional systemic manifestation in several organs [systemic lupus erythematosus (SLE)] ( 1 ). (frontiersin.org)
- CLE can be classified based on clinical and histopathologic findings: typical morphological subsets are acute cutaneous (ACLE), subacute cutaneous (SCLE), intermittent cutaneous [ICLE, also termed lupus erythematosus tumidus (LET)], and chronic cutaneous (CCLE) lupus erythematosus ( 2 , 3 ). (frontiersin.org)
- In a 2009 study from Olmstead County, Minnesota, Durosaro et al demonstrated that the incidence of cutaneous lupus erythematosus (CLE) is comparable to that of SLE. (medscape.com)
- Treatment of underlying disease - Suppression of activity of the associated autoimmune disease is suggested based upon the theory that autoimmune disease-related tissue injury contributes to risk for cutaneous calcification ( algorithm 1 ) [ 2 ]. (medilib.ir)
Discoid17
- Patients with systemic lupus erythematous develop discoid lupus lesions with some frequency. (wikipedia.org)
- However, patients who present initially with discoid lupus infrequently develop systemic lupus. (wikipedia.org)
- Discoid lupus can be divided into localized, generalized, and childhood discoid lupus. (wikipedia.org)
- Discoid lupus erythematosus (DLE) skin lesions first present as dull or purplish red, disc-shaped flat or raised and firm areas of skin. (wikipedia.org)
- When discoid lupus is on the scalp, it starts as a red flat or raised area of skin that then loses hair and develops extensive scarring. (wikipedia.org)
- When discoid lupus is on the lip, it often has a grey or red colour with a thickened top layer of skin (known as hyperkeratosis), areas where the top layer has worn away (known as erosion), and a surrounding rim of redness. (wikipedia.org)
- Sun exposure triggers lesions in people with discoid lupus erythematous (DLE). (wikipedia.org)
- However, scientists do not understand the connection between these antibodies and the lesions seen in discoid lupus. (wikipedia.org)
- When a patient initially presents with discoid lupus, the doctor should ensure that the patient does not have systemic lupus erythematosus. (wikipedia.org)
- If the patients do indeed have discoid lupus, the doctor may see tiny spines of keratin that look like carpet tacks and are called langue au chat. (wikipedia.org)
- Discoid lupus erythematosus on the face. (medscape.com)
- Chronic scarred lesion of discoid lupus erythematosus. (medscape.com)
- However, the exact etiology of discoid lupus erythematosus (DLE) is not well understood. (medscape.com)
- However, B cells are increasingly considered to have additional functions, supported by studies finding them to occur in highest numbers in chronic discoid lupus erythematosus (CDLE), a subtype in which autoantibodies are often absent. (frontiersin.org)
- CCLE can be further subdivided into chronic discoid lupus erythematosus (CDLE), lupus erythematosus profundus (LEP) and chilblain lupus erythematosus (ChLE), of which CDLE represents the most frequent CCLE subtype ( 4 ). (frontiersin.org)
- Discoid lupus erythematosus (DLE) is responsible for 50-85% of cases of CLE and occurs 2-3 times more frequently in women than in men. (medscape.com)
- Although the prognosis of patients with discoid lupus erythematosus (DLE) is favorable regarding mortality, morbidity can be considerable. (medscape.com)
Etiology3
- CONCLUSION: The presence of ghost adipocytes is a rather unique histopathological feature consistent with pancreatic panniculitis and should be considered in combination with the overall clinical picture to determine the underlying etiology. (bvsalud.org)
- The present study aimed to report all the cases of children admitted to our tertiary pediatric hospital with the diagnosis of EN to evaluate the epidemiology, clinical manifestations, etiology, treatment, and the course of this disease in the pediatric age. (bvsalud.org)
- Systemic lupus erythematosus is a chronic, multisystem, inflammatory disorder of autoimmune etiology, occurring predominantly in young women. (merckmanuals.com)
Associated with systemic1
- Nephrology: nephritis, nephritic proteinuria associated with systemic autoimmune disease. (clevelandclinic.org)
Chronic2
- Lupus is a chronic condition, but you may not experience symptoms constantly. (healthline.com)
- Rheumatoid Arthritis (RA) Rheumatoid arthritis is a chronic systemic autoimmune disease that primarily involves the joints. (merckmanuals.com)
Profundus1
- The most common conditions associated with facial lipoatrophy are antiretroviral therapy for HIV infection and connective tissue disorders that are associated with panniculitis such as lupus lupus erythematosus profundus and localized scleroderma also known as morphea [ 4 ]. (biomedcentral.com)
Systemic lupus8
- DLE may occur in the absence of systemic disease, or it may occur in association with systemic lupus erythematosus (SLE). (medscape.com)
- [ 4 ] Overall, patients with DLE rarely fulfill four or more of the 17 Systemic Lupus International Collaborating Clinics (SLICC) criteria used to classify SLE. (medscape.com)
- Worldwide, the prevalence of systemic lupus erythematosus (SLE) ranges from 17-48 cases per 100,000 population. (medscape.com)
- Systemic lupus erythematosus (SLE). (clevelandclinic.org)
- The most common form of lupus is known as systemic lupus erythematosus (SLE). (healthline.com)
- Overview of Systemic Lupus. (merckmanuals.com)
- Systemic lupus erythematosus (SLE) is more common and severe among Black and Asian patients than among White patients. (merckmanuals.com)
- Systemic lupus erythematosus (SLE) is a complex connective tissue disorder that involves multiple organs. (bmj.com)
Connective4
- Rheumatic and autoimmune diseases are disorders which can affect any part of the body including the joints, muscles, connective tissues, and soft tissues around the joints and bones. (clevelandclinic.org)
- Treatment principles - The treatment of dystrophic calcinosis cutis associated with autoimmune connective tissue disease is often difficult. (medilib.ir)
- Is the underlying autoimmune connective tissue disease adequately treated? (medilib.ir)
- Treatment of calcinosis - Treatment of calcinosis cutis associated with autoimmune connective tissue diseases involves careful consideration of the need for treatment and the selection of an appropriate treatment regimen. (medilib.ir)
Subcutaneous nodules1
- Tumid lupus typically presents with juicy papules and plaques that lack scale and heal without scarring, whereas lupus panniculitis involves the subcutaneous tissue, leading to painful subcutaneous nodules that heal with depression and atrophy. (medscape.com)
Organs1
- Our center is recognized for excellence in the diagnosis and management of a variety of inflammatory and autoimmune disorders that affect the joints, muscles, skin, blood vessels, brain, and other vital organs. (clevelandclinic.org)
Symptoms12
- Many people living with lupus experience periods of time when symptoms are worse than usual, known as flares. (healthline.com)
- Lupus can affect nearly any part of your body, so symptoms can be extremely varied from person to person - and even from flare to flare. (healthline.com)
- When the disease is active and there are new or worsening symptoms, it's called a lupus flare. (healthline.com)
- When lupus is active, it means that you're experiencing symptoms. (healthline.com)
- Lupus symptoms can mimic the symptoms of other conditions and can be subtle enough that they're only detected on lab tests. (healthline.com)
- If you have been in a period of remission and you notice your lupus symptoms returning, you may be experiencing the start of a flare. (healthline.com)
- Symptoms you may experience as part of a lupus flare are the result of this damage and inflammation. (healthline.com)
- Lupus is a very individualized condition, so your symptoms during flares may be very different from other people living with lupus. (healthline.com)
- What can I do to manage my lupus symptoms? (healthline.com)
- When lupus symptoms appear, your healthcare team is your first line of defense. (healthline.com)
- [1] Symptoms typically occur intermittently with periods of no symptoms between flares. (wikizero.com)
- It typically begins slowly, and a pattern of symptoms may appear over months or years. (100arthritis.com)
Joints1
- Psoriatic arthritis is an autoimmune disease that attacks the joints. (100arthritis.com)
Prevent lupus2
- There are steps you can take to prevent lupus flares and feel better once they hit. (healthline.com)
- 15 The key role of aberrant B cell autoreactivity in SLE was revealed in a landmark murine study using a knockout gene mutation to prevent lupus mice from developing B cells, which resulted in a lack of autoantibody formation and clinical manifestations (nephritis or vasculitis). (bmj.com)
Photosensitivity1
- Pamphlets from the Lupus Foundation of America, Inc. concerning skin disease and photosensitivity are useful adjuncts to verbally delivered information. (medscape.com)
Workup1
- Investigations, including a full autoimmune workup, were unremarkable. (biomedcentral.com)
Inflammatory2
- Inflammation in lupus is caused by the formation of autoantibodies and immune complexes and can cause inflammatory responses and activate the complement system. (bmj.com)
- PIH results from overproduction of melanin or irregular dispersion of pigment and typically manifests in a pattern of distribution identical to the initial inflammatory process. (barefacedtruth.com)
Commonly1
- The lesions are typically symmetrical, with the ankles and thighs most commonly involved, followed by the wrists and upper arms. (medscape.com)
Diagnosis5
- This observational study retrospectively considered all children evaluated to the emergency room (ER) of Meyer Children's University Hospital, Florence, Italy, discharged with a diagnosis of EN over a 12-year period (from January 2009 to December 2021). (bvsalud.org)
- The etiologic diagnosis of EN was made in 38 children (55.9%): 29 (42.6%) had infection-related EN (in particular EBV and ß-hemolytic streptococcus), 6 (8.8%) had Crohn's disease, 1 celiac disease, 1 Sjogren syndrome, and 1 Hodgkin lymphoma. (bvsalud.org)
- In 30 patients (45%), no definitive diagnosis was reached, and they were defined as having idiopathic EN. (bvsalud.org)
- The Center for Pediatric Rheumatology provides comprehensive diagnosis, treatment, and follow-up care for children and adolescents who are living with juvenile arthritis and a wide range of autoimmune and rheumatologic diseases. (clevelandclinic.org)
- [9] Diagnosis is typically by colonoscopy with tissue biopsies . (wikizero.com)
Manifestation1
- INTRODUCTION: Pancreatic panniculitis is a rare skin manifestation of pancreatic disease. (bvsalud.org)
Mutation1
- Six cases with HAVCR2Y82C mutation manifested with HLH without panniculitis. (bvsalud.org)
Subtypes1
- Lupus erythematosus is a polygenic autoimmune disease linked to various HLA subtypes, immune signaling, and environmental factors, which ultimately leads to autoantibody production and T-cell dysfunction. (medscape.com)
Antibodies3
- Most experts consider DLE an autoimmune disease since pathologists see antibodies when they biopsy the lesions and look at the tissue under the microscope. (wikipedia.org)
- Studies have shown that people with certain antibodies indicating active lupus, increased protein in the urine, and arthritis are more likely to have severe lupus flares. (healthline.com)
- Goodpasture syndrome is an autoimmune disorder characterized by pulmonary hemorrhage and rapidly progressive glomerulonephritis in association with antibodies to alveolar and glomerular basement membrane (GBM). (rheumaknowledgy.com)
Syndrome4
- Hematology: autoimmune cytopenia, autoimmune lymphoproliferative syndrome (ALPS). (clevelandclinic.org)
- Common manifestations may include arthralgias and arthritis, Raynaud syndrome, malar and other rashes, pleuritis or pericarditis, renal or central nervous system involvement, and autoimmune cytopenias. (merckmanuals.com)
- Some drugs (eg, hydralazine , procainamide , isoniazid , anti-tumor necrosis factor [TNF] drugs) cause a reversible lupus-like syndrome. (merckmanuals.com)
- This provides an explanation for why end-organ involvement of Goodpasture syndrome is typically limited to the lungs and kidneys. (rheumaknowledgy.com)
Disease1
- Pancreatic panniculitis can be a primary presenting feature and possible complication of pancreatic disease. (bvsalud.org)
Symmetric1
- Symmetric proximal muscle weakness is typically present. (rheumaknowledgy.com)
Medication1
- Iatrogenic lipoatrophy is typically caused by medication injections. (biomedcentral.com)
Immune2
- Lupus is an autoimmune condition that causes your body's immune system to attack its own tissues. (healthline.com)
- Autoimmune conditions like lupus cause your body's immune system to start recognizing healthy cells as invaders, like bacteria or viruses. (healthline.com)
Triggers2
- Staying out of the sun, getting enough sleep, and taking care of your physical health are great ways to avoid common triggers for lupus flares. (healthline.com)
- SLE may be precipitated by currently unknown environmental triggers that cause autoimmune reactions in genetically predisposed people. (merckmanuals.com)
Frequent1
- Erythema nodosum (EN), although relatively uncommon in the pediatric population, is the most frequent type of panniculitis in children. (bvsalud.org)
Rarely1
- FDG uptake in the panniculitis lesion is rarely reported in the literature. (bvsalud.org)
Biopsy1
- Skin excisional biopsy was performed, and the results suggested panniculitis. (bvsalud.org)
Carcinoma1
- Basal Cell Carcinoma: The most common form of skin cancer, typically caused by sun exposure. (dralpana.com)
Patients2
- Germline HAVCR2 mutations are frequently detected in subcutaneous panniculitis-like T-cell lymphoma (SPTCL) patients with/without hemophagocytic lymphohistiocytosis (HLH) but factors associated with variable manifestations remain undetermined. (bvsalud.org)
- Sixty-eight patients with EN were included. (bvsalud.org)
Flares2
- The things that trigger your lupus flares may also be different. (healthline.com)
- Lupus can be unpredictable, but learning to manage your flares is possible. (healthline.com)
Types1
- This is particularly true for those with higher Fitzpatrick skin types who may not typically normally wear sunscreen or realize the darkening effects UV irradiation has on hyperpigmentation. (barefacedtruth.com)
Parts1
- This form of lupus affects many parts of the body and can be difficult to diagnose. (healthline.com)
Condition1
- There's no cure for lupus, but learning to manage your condition is possible. (healthline.com)
Cells1
- In the case of autoimmune conditions, the healthy cells are recognized as invaders. (healthline.com)
Feature1
- Lupus erythematosus (LE) skin lesions typically feature a histopathologic pattern termed interface dermatitis, defined by the presence of necroptotic keratinocytes and an epitheliotropic cytotoxic lymphocytic infiltrate at the dermo-epidermal junction ( 7 , 8 ). (frontiersin.org)