Usual interstitPneumoniasPneumoniaFibrosisILDsConnectiveNonspecificDiagnosisInflammationPathogenesisBiopsyHistopathologicInfiltrationChronic diseasePatientsInvolvementSevereDyspneaClinicalFindingsPneumonitisTissueAlveolarInfiltratesAutoantibodiesFibroticParenchyma2021Parenchymal lungEndothelialEpidemiologyLymphoidHeterogeneous groupRadiographsSpecimensPathophysiologyRheumatoidImmune-mediatedManifestationsAutoimmune diseasesCoronavirus disease 2019ProgressionEmerg Infect DisLiverTuberculosisSclerodermaSystemic autoimmune rheumaticDermatomyositis
Usual interstit5
- ILD associated with CTDs (CTD-ILD) may display a variety of histologic subtypes, including usual interstitial pneumonia (UIP), nonspecific interstitial pneumonia (NSIP), organizing pneumonia (OP), diffuse alveolar damage, lymphoid interstitial pneumonia (LIP), bronchiectasis, constrictive bronchiolitis, follicular bronchiolitis, and alveolar hemorrhage. (medscape.com)
- The clinical characteristics of chronic HP can be indistinguishable from those of idiopathic interstitial pneumonia (IIP) particularly in the advanced stages and the histological features on surgical lung biopsy may greatly overlap with those of usual interstitial pneumonia (UIP) and fibrotic nonspecific interstitial pneumonia 4 . (e-trd.org)
- The persisting and aggravating chronic dyspnea and diffuse interstitial pattern on chest imaging, led to extensive investigation in order to further characterize his lung disease, disclosing usual interstitial pneumonia (UIP) histologic type lung involvement. (pneumon.org)
- Diagnosis of usual interstitial pneumonia and distinction from other fibrosing interstitial lung diseases. (pneumon.org)
- Conversely, the presence of basal, subpleural, reticular opacities, which are associated with honeycombing and traction bronchiectasis, would be highly typical of Usual Interstitial Pneumonia (UIP) and would probably preclude the need for further investigation. (biomedcentral.com)
Pneumonias6
- Unclassifiable ILDs, autoimmune ILDs, chronic hypersensitivity pneumonitis, sarcoidosis, myositis, Sjögren syndrome, coal worker pneumoconiosis, and idiopathic forms of interstitial pneumonias (eg, idiopathic nonspecific interstitial pneumonia [NSIP]) are among the diseases that may develop a progressive form of chronic fibrosing ILD. (medscape.com)
- Idiopathic interstitial pneumonias (IIP) are associated with an increased lung cancer (LC) risk. (nih.gov)
- Other major histopathologic forms of idiopathic interstitial pneumonias include the following: desquamative interstitial pneumonia (DIP), respiratory bronchiolitis interstitial lung disease (RBILD), acute interstitial pneumonitis (AIP), also known as Hamman-Rich syndrome, nonspecific interstitial pneumonia (NSIP), cryptogenic organizing pneumonia (COP) (see Bronchiolitis Obliterans Organizing Pneumonia ), and lymphocytic interstitial pneumonia (LIP) (see Lymphocytic Interstitial Pneumonia ). (medscape.com)
- Occult connective tissue diseases mimicking idiopathic interstitial pneumonias. (pneumon.org)
- Detection of antisynthetase syndrome in patients with idiopathic interstitial pneumonias. (ijcdas.com)
- Major eosinophilic lung diseases are the eosinophilic pneumonias caused by infections, allergens, or toxic agents. (lookformedical.com)
Pneumonia11
- [ 9 ] To address this, the European Respiratory Society and American Thoracic Society released a joint consensus statement in 2015 proposing the term "interstitial pneumonia with autoimmune features" (IPAF) be used for "idiopathic interstitial pneumonia" (IIP) with clinical features that suggest an underlying autoimmune process. (medscape.com)
- Of 265 patients with idiopathic pulmonary fibrosis (IPF), 142 with non-specific interstitial pneumonia (NSIP), and 71 with cryptogenic organizing pneumonia (COP), 16%, 4%, and 6% were affected byLC, respectively. (nih.gov)
- The presence of peribronchiolar interstitial fibrosis and limited bronchiolo-centric granuloma formation associated with a UIP or nonspecific interstitial pneumonia-like background is indicative of chronic HP 7 - 10 . (e-trd.org)
- Tissue from the open lung biopsy of the third patient indicated severe organizing fibrinous pneumonia with bronchiolitis obliterans and diffuse alveolar damage. (cdc.gov)
- Pneumocystis first came to attention as a cause of interstitial pneumonia in severely malnourished and premature infants during World War II in Central and Eastern Europe. (medscape.com)
- Depending on the virulence of the organism, as well as the age and comorbidities of the patient, viral pneumonia can vary from a mild and self-limited illness to a life-threatening disease. (medscape.com)
- Bilateral interstitial infiltrates in a 31-year-old patient with influenza pneumonia. (medscape.com)
- Parainfluenza virus (PIV) is second in importance only to RSV as a cause of lower respiratory tract disease in children and pneumonia and bronchiolitis in infants younger than 6 months. (medscape.com)
- Histopathologic examination of the lung showed severe pulmonary edema and interstitial pneumonia with inflammatory cell infiltration. (flu.org.cn)
- In some conditions there is a long time of our infectious diseases clinic with acute between the initial and final diagnosis of presentation of pneumonia failed to respond chronic pneumonia, which usually occurs to treatment. (who.int)
- Introduction: A cluster of pneumonia cases of unknown origin was first reported in Wuhan China then the causative pathogen was identified and named severe acute respiratory syndrome coronavirus 2 (SARS-Cov2) and the associated disease was named coronavirus disease 2019 (COVID-19). (bvsalud.org)
Fibrosis26
- In the early stages of lung injury, the degree of inflammation of interstitial and alveolar spaces is associated with subsequent fibrosis. (medscape.com)
- Following the initial insult, further activation of fibroblasts and myofibroblasts leads to lung fibrosis and scarring. (medscape.com)
- We evaluated whether lysyl oxidase-like 2 (LOXL2), which promotes cross-linking of collagen in pathological stroma, was detectable in serum from idiopathic pulmonary fibrosis (IPF) patients, and assessed its relationship with IPF disease progression. (ersjournals.com)
- Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal disease of the lungs involving airway epithelial cell damage, fibroblast activation and proliferation, and excessive deposition of collagen and other extracellular matrix (ECM) components [ 1 ]. (ersjournals.com)
- LOXL2 has also been localised to the active disease interface in liver fibrosis [ 9 ], and is considered a "core" driver in fibrosis [ 10 ]. (ersjournals.com)
- Idiopathic pulmonary fibrosis: Disease mechanisms and drug development. (nih.gov)
- Mechanisms of progressive fibrosis in connective tissue disease (CTD)-associated interstitial lung diseases (ILDs). (nih.gov)
- DPLD may be idiopathic, a classic illustration of which is idiopathic interstitial fibrosis (IPF), which is discussed in another article (see Pulmonary Fibrosis, Idiopathic ). (medscape.com)
- It is thought to begin with acute injury to the pulmonary parenchyma, leading to chronic interstitial inflammation, then to fibroblast activation and proliferation, and finally progressing to the common endpoint of pulmonary fibrosis and tissue destruction. (medscape.com)
- Histopathologic evaluation showed severe fibrosis, alveolar collapse, honeycombing, macrophage and mast cell accumulation, vascular smooth muscle hypertrophy, and other indications of severe progressive interstitial pulmonary fibrosis and end-stage lung disease. (cdc.gov)
- In recent years, multiple studies have reported that DIS has immunoregulation, anti‑fibrosis, anti‑inflammation, anti‑viral and anti‑tumor effects. (spandidos-publications.com)
- However, the mechanism by which DIS ameliorates renal fibrosis and inflammation remains to be elucidated. (spandidos-publications.com)
- The aim of the present study was to investigate the role of DIS in renal fibrosis and inflammation and to explore its underlying mechanism. (spandidos-publications.com)
- It used network pharmacology to predict the targets of DIS for the treatment of renal interstitial fibrosis. (spandidos-publications.com)
- DIS ameliorated renal fibrosis by inhibiting the NF‑κB signaling pathway‑mediated inflammatory response, which may be a therapeutic pathway for delaying chronic kidney disease. (spandidos-publications.com)
- Renal fibrosis is an important pathological alteration in the progression of CKD to end-stage renal disease. (spandidos-publications.com)
- Renal fibrosis is mainly divided into two parts: glomerular fibrosis and interstitial fibrosis ( 4 ) and the present study only focused on renal interstitial fibrosis, which is characterized by infiltration of inflammatory cells and deposition of collagen fiber with various degrees of renal insufficiency. (spandidos-publications.com)
- The inflammatory response is a critical part of renal interstitial fibrosis, which is mainly accomplished by two types of inflammatory cells, macrophages and lymphocytes ( 4 , 7 , 8 ). (spandidos-publications.com)
- Acute and chronic inflammation often leads to fibrosis, which is also the common and final pathological outcome of chronic inflammatory diseases. (frontiersin.org)
- To explore the common genes and pathogenic pathways among different fibrotic diseases, we collected all the reported genes of the eight fibrotic diseases: eye fibrosis, heart fibrosis, hepatic fibrosis, intestinal fibrosis, lung fibrosis, pancreas fibrosis, renal fibrosis, and skin fibrosis. (frontiersin.org)
- The clinical manifestations are renal disease, idiopathic pulmonary fibrosis (IPF), heart failure, end-stage liver diseases, and so on ( Bataller and Brenner, 2005 ). (frontiersin.org)
- But the common characteristics of these fibrosis diseases were still unknown. (frontiersin.org)
- Interstitial lung disease (ILD) is a rare condition characterized by extensive inflammation and fibrosis mainly involving the pulmonary interstitium or alveoli. (koreamed.org)
- and whether patients with idiopathic pulmonary fibrosis (IPF) had similar responses to those with other types of ILD. (bmj.com)
- Pulmonary fibrosis share the pathogenesis process of interstitial lung disease which involve the pulmonary parenchyma . (wikidoc.org)
- The primary features of the lung injury includes inflammation , fibrosis , and granulomas development. (wikidoc.org)
ILDs5
- Similarly, interstitial lung diseases (ILDs) are a heterogeneous group of lung disorders-characterized by parenchymal lung injury as a consequence of systemic autoimmunity-classified on the basis of their radiologic as well as histopathologic features. (medscape.com)
- Several diagnostic tools are essential for making a definitive diagnosis of various interstitial lung diseases (ILDs), including IIPs 11 . (e-trd.org)
- Additionally, successive pulmonary function testing is largely used to check the clinical course of the disease and/or predict the prognosis in patients with ILDs 12 . (e-trd.org)
- Hypersensitivity Pneumonitis (HP) one of the most common interstitial lung diseases (ILDs) is characterized by exposure to an inhaled inciting antigen that leads to a host immunologic reaction determining interstitial. (koreamed.org)
- The interstitial lung diseases (ILDs) are a diverse group of chronic lung conditions characterised by dyspnoea on exertion and poor health related quality of life. (bmj.com)
Connective8
- Although the distinct cause of interstitial lung disease (ILD) in connective disease tissue (CTD) is not known, the underlying pathogenesis is thought to be secondary to varying degrees inflammation, alveolar injury, dysregulated tissue repair, and fibroproliferation. (medscape.com)
- Drugs used to manage connective tissue disease (CTD) associated with interstitial lung disease (ILD) (CTD-ILD) include nintedanib, corticosteroids, and antineoplastic agents. (medscape.com)
- The disease is categorized as a rheumatologic disorder because it affects the connective tissues in the body. (mountsinai.org)
- Overlap" antibodies, like Pm-Scl and U1-RNP, those that support scleroderma features as well as features of another connective tissue disease, like dermatomyositis or lupus, are found in about 30% of children, which is more frequent than adults. (scleroderma.org)
- Healthy ANA − controls and ANA + (ANA ≥1:160 by immunofluorescence) participants with no SARD criteria, with at least one criterion (undifferentiated connective tissue disease (UCTD)), or meeting SARD classification criteria were recruited. (biomedcentral.com)
- In this study, we examined peripheral blood T and B cell populations and their activation in asymptomatic ANA + individuals together with patients with undifferentiated connective tissue disease (UCTD) and early SARD to determine whether the cellular immune characteristics found in SARD are distinct from those seen in asymptomatic ANA + individuals, most of whom will not progress to SARD. (biomedcentral.com)
- We compared the gene overlaps among eight fibrotic diseases and connective tissue growth factor (CTGF) was finally identified as the common key molecule. (frontiersin.org)
- Found in various rheumatic diseases, including SLE, SSc, SSc-autoimmune myopathy overlap syndrome, mixed or undifferentiated connective tissue disease (CTD). (rheumatologyadvisor.com)
Nonspecific2
- The range of manifestations may include none, nonspecific signs and symptoms of illness, autoimmune and neurologic disorders, a variety of opportunistic infections, and several types of malignancy. (cdc.gov)
- interstitial lung disease is of a nonspecific form, although there have beenseveral cases of coexisting inflammatory bowel disease and sarcoidoisis. (geometry.net)
Diagnosis17
- Patients with IIPs diagnosed in a tertiary interstitial lung diseases (ILD) center were reviewed for LC diagnosis. (nih.gov)
- The current report describes a late preterm baby (36 weeks gestational age) with neonatal onset of interstitial lung disease eventually diagnosed as MPS I. The neonate required prolonged respiratory support and oxygen supplementation that further escalated the likely diagnosis of inherited disorders of pulmonary surfactant dysfunction. (mdpi.com)
- the current case definition, a histologically confirmed diagnosis of chronic lymphoid interstitial pneumonitis in a child (under 13 years of age) will be considered indicative of AIDS unless test(s) for HTLV-III/LAV are negative. (cdc.gov)
- more than 3 months after the diagnosis of an opportunistic disease used as a marker for AIDS will no longer be excluded as AIDS cases. (cdc.gov)
- Patients with pSS-ILD report impaired health-related quality of life and a higher risk of death, suggesting the importance of early diagnosis and treatment of this type of pulmonary involvement. (ersjournals.com)
- In order to fully evaluate the disease burden in the pediatric patients, experts in the field recommend the following evaluations during the time of diagnosis. (scleroderma.org)
- Diagnosis of systemic autoimmune rheumatic diseases (SARD) relies on the presence of hallmark anti-nuclear antibodies (ANA), many of which can be detected years before clinical manifestations. (biomedcentral.com)
- The standard method of diagnosis is Pneumocystis detection in broncho alveolar lavage fluid and high-resolution computed tomography can be detected in diffuse interstitial infiltration of both lungs. (ijpsonline.com)
- However, the majority of published studies are based on CXR data, resulting in difficulties for estimation of dose-response relationships for asbestos-related diseases due to imprecise assessment of asbestos exposure but also imprecise radiographic diagnosis of asbestosis and pleural plaques 3 . (ersjournals.com)
- Thoracic high-resolution computed tomography (HRCT) has been clearly demonstrated to be more sensitive and specific than CXR for the diagnosis of asbestos-related diseases 5 . (ersjournals.com)
- Only 54% of patients who received a consensus diagnosis of UIP after VATS lung biopsy, had been given a differential diagnosis of "probable UIP" at CT scan. (biomedcentral.com)
- 15% of patients who received a differential diagnosis of "probable UIP" at CT scan, had their diagnosis changed to Hypersensitivity Pneumonitis after lung biopsy. (biomedcentral.com)
- Indeed, a CT scan which is highly typical of a particular type of ILD, may provide a physician with sufficient confidence to make the diagnosis without further investigation. (biomedcentral.com)
- When a diagnosis has been not achieved by CT imaging, patients can be investigated by bronchoscopy, with Bronchoalveolar Lavages (BALs) and Transbronchial Lung Biopsies (TBLBs) being performed. (biomedcentral.com)
- Infrequently, lung biopsy is required to establish a diagnosis in very ill patients, who often are immunocompromised. (medscape.com)
- Prompt diagnosis and treatment of malaria can prevent severe disease or death and limit ongoing transmission to local Anopheles mosquitoes and other persons. (cdc.gov)
- Clinical diagnosis was correct in 43.4% of cases suspected of tuberculosis and 69.2% of cases suspected of lung cancer. (who.int)
Inflammation1
- A condition characterized by infiltration of the lung with EOSINOPHILS due to inflammation or other disease processes. (lookformedical.com)
Pathogenesis1
- These modifications of ECM composition and organisation alter the biomechanical properties of the lung parenchyma and increase local tension, which is critical in IPF disease pathogenesis [ 5 ]. (ersjournals.com)
Biopsy5
- Patients with CTD who develop drug-induced ILD may also manifest a variety of histologic patterns in lung biopsy specimens. (medscape.com)
- Diagnostic studies included sputum gram stain and cultures, blood cultures, serologic tests, and pathologic examination of tissue obtained by open lung biopsy or postmortem. (cdc.gov)
- Diagnosing a specific type of Interstitial Lung Disease (ILD) is a challenging process and often necessitates that a Video-assisted Thoracoscopic Surgery (VATS) Lung Biopsy be performed. (biomedcentral.com)
- By analysing the proportion of patients who have their treatment changed after undergoing a VATS lung biopsy, this study aimed to determine the utility of performing this procedure in patients with ILD. (biomedcentral.com)
- The main outcome measures considered in this study were: CT scan differential diagnoses, VATS lung biopsy histological differential diagnoses, post-VATS lung biopsy consensus diagnoses, 30-day mortality, surgical complications (minor and major), resultant changes in treatment and responses to these changes in treatment. (biomedcentral.com)
Histopathologic2
- Histopathologic analysis of lung tissue from the two deceased patients indicated diffuse alveolar damage with microemboli and minimal inflammatory cell infiltrate. (cdc.gov)
- Primary studies of any design that pulmonares asociados had primary data on histopathologic findings of lungs in COVID-19 patients were included. (bvsalud.org)
Infiltration1
- Primary Sjogren syndrome (pSS) is a systemic autoimmune disease characterised by lymphocytic infiltration of exocrine glands and by a number of systemic manifestations, including those regarding the lung. (ersjournals.com)
Chronic disease1
- SSc, a chronic disease with multisystemic involvement, is characterized by widespread collagen deposition. (medscape.com)
Patients34
- [ 7 , 8 ] It has been suggested that some patients with ILD and autoimmune features who do not meet clinical criteria for CTDs may have a lung-predominant form of a CTD. (medscape.com)
- Fifty percent of patients with SSc go on to develop clinically significant lung disease (SSc-ILD). (medscape.com)
- Nintedanib is indicated to slow the rate of decline in pulmonary function in patients who have interstitial lung disease (ILD) associated with scleroderma. (medscape.com)
- He introduced bronchoalveolar lavage in TB patients and developed the concept of comparing BAL in the involved to the uninvolved lung. (wikipedia.org)
- Patients from the ARTEMIS-IPF (n=69) and the Genomic and Proteomic Analysis of Disease Progression in IPF (GAP) (n=104) studies were analysed. (ersjournals.com)
- The routinely employment of ES and proper software, combined to clinical findings (cough, dyspnea) and respiratory lung function, could increase our ability to early identify ILD in RA patients. (unimore.it)
- We identified subgroups of patients with fibroproliferative and inflammatory SSc with more severe pathophenotypes, such as higher MRSS and increased likelihood of interstitial lung disease (ILD). (jci.org)
- Our results demonstrate an association among the activation of regulators, gene expression subsets, and clinical variables that can identify patients with SSc with more severe disease. (jci.org)
- patients will be excluded as AIDS cases if they have a negative result on testing for serum antibody to HTLV-III/LAV, have no other type of HTLV-III/LAV test with a positive result, and do not have a low number of T-helper lymphocytes or a low ratio of T-helper to T-suppressor lymphocytes. (cdc.gov)
- [ 40 ] Less often, patients develop dyspnea from an interstitial lung disease that is typically mild. (medscape.com)
- In contrast, airway disease usually has little effect on respiratory function and is rarely the cause of death in these patients. (ersjournals.com)
- Krebs von den Lungen-6 (KL-6) is now classified as a human MUC1 mucin protein, and regenerating type II pneumocytes are the primary cellular source of KL-6/MUC1 in the affected lungs of patients with interstitial lung diseases (ILD). (e-trd.org)
- Of patients referred to a pulmonary disease specialist, an estimated 10-15% have a DPLD. (medscape.com)
- Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is a sometimes life-threatening complication in RA patients. (biomedcentral.com)
- Sarcoidosis in Patients with Celiac Disease. (pneumon.org)
- Ogasawara K, Shiraishi S, Tsuda N, Sakamoto F, Oda S, Takashio S, Tsujita K, Hirai T.Usefulness of quantitative (99m)Tc-pyrophosphate SPECT/CT for predicting the prognosis of patients with wild-type transthyretin cardiac amyloidosis. (kumadai-radiology.jp)
- Analyses of blood (five patients) and lung tissue (three patients) specimens and of samples taken from drug paraphernalia (i.e., homemade 'pipes' of one patient) were negative for potential toxins. (cdc.gov)
- This therapy is used to treat documented hypoxemia (as in case of smokers), severe respiratory distress, severe trauma, interstitial lung disease (ILD), chronic obstructive pulmonary disease (COPD) including chronic asthma and chronic bronchitis, pulmonary hypertension, acute myocardial infarction, and chronic lung patients during exercise. (opednews.com)
- The basic purpose to ventilate patients through oxygen therapy is to improve gas exchange till lung functions improve. (opednews.com)
- Patients with severe immune-mediated inflammatory diseases, e.g. rheumatoid arthritis, Crohn's disease or psoriasis, often respond well and relatively quickly to treatment with biologic medicines such as tumour necrosis factor (TNF) inhibitors. (bpac.org.nz)
- For example, in patients with rheumatoid arthritis, TNF inhibitor treatment can decrease synovitis and prevent joint erosions within months, and sometimes induce disease remission. (bpac.org.nz)
- The clinical data from sixty-six patients with suspected ILD, who underwent VATS lung biopsies at the New Royal Infirmary of Edinburgh (NRIE) in the period of 16th May 2011 - 11th February 2013, were analysed retrospectively. (biomedcentral.com)
- This study highlights the effectiveness of performing VATS lung biopsies in patients with suspected ILD. (biomedcentral.com)
- It has been shown to be a relatively safe procedure and thus, should be performed in all patients with suspected ILD, indeterminate in type from prior CT imaging. (biomedcentral.com)
- Clubbing of the digits and cyanosis may occasionally occur in advanced disease and patients generally exhibit a restrictive pattern on Pulmonary Function Testing. (biomedcentral.com)
- Found in patients with SSc, SSc-AIM overlap syndrome, or clinical manifestations of other rheumatic diseases. (rheumatologyadvisor.com)
- 1 - 3 Treatment options are often limited and patients suffer increasing exercise limitation as their disease progresses. (bmj.com)
- Although exercise training effectively improves exercise capacity and health related quality of life in patients with chronic obstructive pulmonary disease (COPD), 4 its role in patients with ILD is unclear. (bmj.com)
- Current guidelines for exercise prescription in chronic lung disease are based on evidence from studies of patients with COPD 7 where respiratory mechanics and peripheral muscle dysfunction are major limitations to exercise capacity. (bmj.com)
- Patients with solitary colorectal metastasis to the liver have up to a 40% 5-year survival, and patients with multiple metastases (up to four lesions) have been reported to have survival rates of 22% if all visible disease can be resected. (bcmj.org)
- 3 ] Unfortunately, fewer than 30% of patients are candidates for curative surgical resection at the time of presentation because of disease burden or anatomical location of the metastases. (bcmj.org)
- In addition, 25% of patients with colorectal cancer die of hepatic failure secondary to the metastatic disease. (bcmj.org)
- We believe that cysteinyl leukotriene type 1 receptor antagonists are safe and effective drugs for most patients with asthma but caution is needed for those with more severe disease who require systemic corticosteroids, especially if they show characteristics of the atypical allergic diathesis seen in the prodromal phase of Churg-Strauss syndrome. (lookformedical.com)
- Vindell J, Ortiz Muñoz L, Rada was the most frequent histopathological finding in lung specimens from patients with COVID-19. (bvsalud.org)
Involvement6
- Among them, lung involvement is very frequent and interstitial lung disease (ILD) represents one of the deleterious complications of RA with impact on both therapeutic approach and overall prognosis. (unimore.it)
- Periepithelial infiltrative processes include interstitial nephritis, liver involvement, and bronchiolitis and generally follow a benign course. (medscape.com)
- Pulmonary involvement in pSS includes interstitial lung disease (ILD) and airway disease, together with lymphoproliferative disorders. (ersjournals.com)
- Generally, oral and ocular dryness is accompanied by involvement of other types of mucosa such as nose, pharynx, larynx and vagina, that can be the earliest clinical manifestations [ 1 , 11 ]. (ersjournals.com)
- The most common lesion in all species was severe necrotizing bronchopneumonia with (n=12) or without (n=10) interstitial involvement. (bvsalud.org)
- Eosinophilia and lung involvement differentiate this disease from POLYARTERITIS NODOSA. (lookformedical.com)
Severe6
- The coronavirus disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus 2, emerged in late 2019 and soon developed as a pandemic leading to a world health crisis. (cnr.it)
- Rarely, if this type of scleroderma affects children or young adults, it may interfere with growth and cause severe deformities in the arms and legs. (mountsinai.org)
- We present for the first time a patient, who from his first months of life developed several autoimmune endocrine and non disorders such as type 1 diabetes, autoimmune thyroiditis, and vitiligo [the constellation of polyglandular autoimmune syndrome IIIA (PG IIIA) manifestations], severe osteoporosis, as well as celiac disease (CD) diagnosed at the age of 9 years-old. (pneumon.org)
- On his last admission in our department because of fever and severe deterioration of respiratory status, the patient developed acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), the so called UIP "acute exacerbation", ending to death. (pneumon.org)
- A) Severe congestion and edema in the lung. (flu.org.cn)
- Influenza B viruses may cause milder disease but often cause epidemics with moderate or severe disease, either as the predominant circulating virus or along with influenza A. (msdmanuals.com)
Dyspnea1
- We present a case of a 67-year-old man who had uncontrolled type 2 diabetes and complained of coughing, dyspnea, and fever. (ijcdas.com)
Clinical7
- Baseline serum LOXL2 (sLOXL2) levels were compared with baseline clinical and physiological surrogates of disease severity, and the association with IPF disease progression was assessed using a classification and regression tree (CART) method. (ersjournals.com)
- Chest imaging examination plays a vital role in the clinical management and prognostic evaluation of COVID-19 since the imaging pathological findings reflect the inflammatory process of the lungs. (cnr.it)
- Several studies incorporating clinical, radiological, and pathological findings have subsequently evolved but have not led to a consensus on the clinical definition of the disease. (e-trd.org)
- These cases have been characterized by a variety of clinical syndromes including pulmonary edema, interstitial pneumonitis, obliterative bronchitis, and pulmonary hemorrhage (1-6). (cdc.gov)
- Most experts agree that treatment in a clinical trial should be considered for any type or stage of vaginal cancer. (cancer.org)
- Signs and symptoms of the sensitivity and specificity of clinical di- lower respiratory tract infection are, how- agnosis. (who.int)
- Changes in vascular permeability are lial cells tethered together by junctional proteins commonly present in certain clinical diseases such as tight and adherens junctions. (bvsalud.org)
Findings4
- His findings in collaborative studies for early detection of lung cancer focused on networks of immune response, metabolism, growth factors and receptors, signaling pathways, cytokines, and altered methylation biomarkers. (wikipedia.org)
- Our findings show the spectrum of disease associated with SkAdV-1 infection in a broad host range of wildlife species. (bvsalud.org)
- Biochemical findings in animals exposed to ozone and nitrogen dioxide included increased lung content of DNA, protein, collagen, and elastin, which was about 300% higher than the control values. (cdc.gov)
- Lung examination findings reveal an interstitial pneumonitis made up of edema fluid, mononuclear cells, and lymphocytes with polymorphonuclear leukocytes. (medscape.com)
Pneumonitis3
- Hypersensitivity pneumonitis (HP) is an increasingly recognized form of diffuse parenchymal lung disease. (e-trd.org)
- Hypersensitivity pneumonitis (HP) formerly recognized as extrinsic allergic alveolitis is the consequence of immunologically mediated type III and type IV hypersensitivity reaction caused by recurrent exposure to various inhaled antigenic stimuli, whether overt or occult 1 , 2 . (e-trd.org)
- The underlying histopathology of IPF is usual interstitial pneumonitis (UIP). (medscape.com)
Tissue6
- LOXL2 protein expression is observed in the fibroblastic foci and collagenous regions of diseased IPF lung tissue, with relatively minor expression in healthy lung tissue [ 9 ]. (ersjournals.com)
- These numerous functions involving filamin A have been found to play roles in regulating skeletal and brain development, the formation of heart tissue and blood vessels, blood clotting, skin elasticity, the maintenance of lung tissue, and the function of the digestive system. (medlineplus.gov)
- Positive lung tissue from the dog that was incubated with phosphate-buffered saline instead of the mouse monoclonal antibody antinucleoprotein of influenza A H5N1, and tissue from the liver and lung of a cat killed by a car served as negative control ( 2 ). (flu.org.cn)
- H5N1 viruses were isolated from the dog´s lung tissue and designated A/Dog/Thailand/KU-08/04. (flu.org.cn)
- Normally, collagen is degraded and produced regularly to preserve the normal lung tissue. (wikidoc.org)
- However, immunopathogenic responses of lung tissue are quite similar. (wikidoc.org)
Alveolar4
- He showed that TB mycobacteria induced alveolar macrophages to secrete cytokines that directed transcription factors to stimulate high-level HIV replication in TB-infected areas of the lung. (wikipedia.org)
- Fig. 3: Phagocytosis function of newly formed resident lung alveolar macrophages is altered locally by secondary inflammatory mediators released during infection. (nature.com)
- Hyaline membranes appear along with a proliferation of type 2 alveolar lining cells. (medscape.com)
- As the disease progresses, the alveolar septa become increasingly fibrotic. (medscape.com)
Infiltrates1
- Frontal chest radiograph demonstrating bilateral reticular and nodular interstitial infiltrates with upper zone predominance. (medscape.com)
Autoantibodies1
- Interstitial lung disease with autoantibodies against aminoacyl-tRNA synthetases in the absence of clinically apparent myositis. (ijcdas.com)
Fibrotic4
- We calculated the Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) enrichment scores of all fibrotic disease genes. (frontiersin.org)
- For each fibrotic disease, by comparing the KEGG and GO enrichment scores between reported disease genes and other genes using the Monte Carlo feature selection (MCFS) method, the key KEGG and GO features were identified. (frontiersin.org)
- The key KEGG and GO features of the eight fibrotic diseases were all screened by MCFS method. (frontiersin.org)
- Honeycomb appearance of a fibrotic lung. (wikidoc.org)
Parenchyma2
- These results are consistent with extensive breakdown and remodeling of the lung parenchyma and its associated vasculature. (cdc.gov)
- Interstitial lung disease is a group of disorders that involve pulmonary parenchyma . (wikidoc.org)
20212
- Tuberculosis and Respiratory Diseases 2021;84(3):200-208. (e-trd.org)
- Rheum Dis Clin North Am . 2021 Nov;47(4):757-780. (scleroderma.org)
Parenchymal lung1
- Diffuse parenchymal lung diseases (DPLDs) comprise a heterogenous group of disorders. (medscape.com)
Endothelial2
- NOS catalyzes the oxidization of L-arginine to produce L-citrulline and NO. Two constitutive isoforms, brain or neuronal NOS (b or nNOS, type I) and endothelial cell NOS (eNOS, type III), and one inducible isoform (iNOS, type II), have been cloned. (thermofisher.com)
- These cell- and when occurring in the lung or brain lead to to-cell connections allow for the formation of serious consequences related to impaired gas inter-endothelial gaps through which substances exchange and cerebral function, respectively. (bvsalud.org)
Epidemiology1
- [ 1 ] . Rates of interstitial lung disease are somewhat higher in men than in women, and the epidemiology is markedly affected by age and occupational exposures. (medscape.com)
Lymphoid1
- The MDSCs were increased, while Th17 cells, group 1 innate lymphoid cells (ILC1s), and GM-CSF+ILCs were decreased in the lungs of tofacitinib-treated mice. (biomedcentral.com)
Heterogeneous group2
- 16 In addition, ILD is a heterogeneous group of diseases. (bmj.com)
- A heterogeneous group of disorders with the common feature of prolonged eosinophilia of unknown cause and associated organ system dysfunction, including the heart, central nervous system, kidneys, lungs, gastrointestinal tract, and skin. (lookformedical.com)
Radiographs1
- Most studies on asbestos-related diseases are based on chest radiographs, and dose-response relationships are still controversial. (ersjournals.com)
Specimens1
- Influenza virus was isolated from lung, liver, kidney, and urine specimens, and the viral subtype was determined to be H5N1 by reverse transcription (RT)-PCR ( 6 ). (flu.org.cn)
Pathophysiology2
- 2 A lack of response may be due to differences in the pathophysiology of the patient's condition, differences in genetics or the treatment being only effective at certain stages of a disease. (bpac.org.nz)
- One approach to understanding its pathophysiology is to know the histopathological damage generated in the lungs of those affected. (bvsalud.org)
Rheumatoid7
- Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial joint swelling and tenderness, secondary to the immune-system dysfunction, often complicated by extra-articular manifestations. (unimore.it)
- SS can occur as a primary disease (primary SS (pSS)) or be associated with another autoimmune disease, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), dermatomyositis, or systemic sclerosis (SSc) [ 1 ]. (ersjournals.com)
- Interstitial lung disease (ILD) is sometimes a complication of rheumatoid arthritis (RA), in which case it is called rheumatoid arthritis-associated ILD (RA-ILD). (biomedcentral.com)
- Rheumatoid arthritis symptoms such as pain and stiffness can be reduced by moderate pressure massage and other types of massage therapy. (elispot.biz)
- But rheumatoid arthritis is also a systemic disease, meaning it can affect the whole body, damage major organs, and even lead to a shortened life span. (elispot.biz)
- Research shows that people who have rheumatoid arthritis may be more likely to develop periodontal disease, which usually starts with a gum infection. (elispot.biz)
- Biologic immunomodulators are often used to treat immune-mediated inflammatory disease, e.g. rheumatoid arthritis and inflammatory bowel disease. (bpac.org.nz)
Immune-mediated2
- Antisynthetase syndrome (ASS) is a rare immune-mediated disorder characterized by interstitial lung disease (ILD) and polymyositis (PM)/dermatomyositis (DM) in association with antiaminoacyl-transfer-RNA antibodies most commonly anti-JO-1 antibodies. (ijcdas.com)
- In New Zealand several biologic medicines are funded under Special Authority criteria or subject to restrictions on the Hospital Medicines List (HML) for the treatment of immune-mediated inflammatory disease ( Table 1 ). (bpac.org.nz)
Manifestations2
- It is worth noting that detecting and quantifying such manifestations is a key step in evaluating disease impact and tracking its progression or regression over time. (cnr.it)
- Sometimes, the disease course can be also complicated by systemic manifestations that can represent the first signs of the disease, also preceding SS by many years [ 11 ]. (ersjournals.com)
Autoimmune diseases3
- The mechanism whereby it affects autoimmune diseases is unknown. (medscape.com)
- Some drugs, such as rituximab (Rituxan), mycophenolate mofetil (CellCept), and imatinib mesylate (Gleevac), used to treat certain autoimmune diseases and cancers may play a role in treating scleroderma. (mountsinai.org)
- HEp-2 IIFAs are commonly used for antinuclear antibody (ANA) detection, the outcomes of which are integrated in diagnostic and classification criteria for many systemic autoimmune diseases. (rheumatologyadvisor.com)
Coronavirus disease 20192
- Predictors of seroconversion after coronavirus disease 2019 vaccination. (mayo.edu)
- Background: Different diagnostic tools could improve early detection of coronavirus disease 2019 (COVID-19). (bvsalud.org)
Progression6
- 800 pg·mL −1 ) was associated with increased risk for disease progression (hazard ratio (HR) 5.41, 95% CI 1.65-17.73). (ersjournals.com)
- 700 pg·mL −1 ) were associated with more disease progression events (HR 1.78, 95% CI 1.01-3.11). (ersjournals.com)
- These results suggest that higher sLOXL2 levels are associated with increased risk for IPF disease progression. (ersjournals.com)
- Although we demonstrated that the CD11b + Gr1 dim tolDC-like cells were differentiated from monocytic MDSCs in the severely inflamed lungs, and suppressed the progression of ILD, the function of MDSCs in the lung was not elucidated. (biomedcentral.com)
- solid tumor (excluding lymphoma), failure to respond to Key Points standard therapy, disease progression despite standard ther- apy, or cancers for which standard therapy did not exist. (sagepub.com)
- Chest radiograph has lower sensitivity for the detection of lung abnormalities but it has a role in disease progression and also in the late stages of COVID19. (bvsalud.org)
Emerg Infect Dis1
- Emerg Infect Dis. (cdc.gov)
Liver2
- Dig Liver Dis. (mayo.edu)
- Forty-eight hours later, allantoic fluids harvested from dead embryos that had been injected with supernatants of ground brain, trachea, lung, intestine, liver, and kidney were tested with the hemagglutination and hemagglutination-inhibition tests. (flu.org.cn)
Scleroderma3
- Scleroderma is an uncommon, complex, autoimmune disease. (mountsinai.org)
- In children, localized scleroderma is three times more common than the systemic form of the disease. (mountsinai.org)
- People with scleroderma may develop either a localized or a systemic (body-wide) form of the disease. (mountsinai.org)
Systemic autoimmune rheumatic1
- Found as high titer HEp-2 IIFA-positive in healthy individuals or in those who do not have a systemic autoimmune rheumatic disease. (rheumatologyadvisor.com)
Dermatomyositis1
- Interstitial lung disease in polymyositis and dermatomyositis. (ijcdas.com)