• A gastrointestinal stromal tumor composed of a mixture of neoplastic epithelioid and spindle cells. (nih.gov)
  • Clinicopathological features, risk profile assessment, and the surgical outcome of gastrointestinal stromal tumors in Lagos, Nigeria. (nih.gov)
  • Pediatric-type" gastrointestinal stromal tumors in adults: distinctive histology predicts genotype and clinical behavior. (nih.gov)
  • Gastrointestinal Stromal Tumours. (nih.gov)
  • Clinicopathological characteristics and outcomes of gastrointestinal stromal tumors with high progranulin expression. (nih.gov)
  • Immune Cell Infiltration and the Expression of PD-1 and PD-L1 in Primary PDGFRA-Mutant Gastrointestinal Stromal Tumors. (nih.gov)
  • Gastrointestinal stromal tumor: clinicopathological characteristics and pathologic prognostic analysis. (nih.gov)
  • Gastrointestinal stromal tumors. (nih.gov)
  • Clinical and pathological characteristics of gastrointestinal stromal tumor (GIST) metastatic to bone. (nih.gov)
  • Lgr5 is a well-established marker of these basal stem cells in the gastrointestinal tract 1 and lineage tracing experiments have demonstrated that Lgr5 + cells give rise to clonal cell populations establishing entire colonic crypts 2 . (nature.com)
  • Expression of Lgr5 is controlled by Wnt signaling, which plays a critical role for stem cell turnover in the gastrointestinal tract 2 . (nature.com)
  • There are several different types, including adenocarcinoma, squamous cell carcinoma, and gastrointestinal stromal tumors (GISTs). (medicalnewstoday.com)
  • Gastrointestinal stromal tumors (GISTs) can start anywhere in the digestive system and form in the stomach lining. (medicalnewstoday.com)
  • Primordial germ cells and gastrointestinal stromal tumors respond distinctly to a cKit overactivating allele. (ca.gov)
  • A constitutively activating mutation, cKit(V558Δ), causes gain-of-function phenotypes in mast cells and intestines, and gastrointestinal stromal tumors (GISTs) when heterozygous. (ca.gov)
  • Gastrointestinal stromal tumors (GISTs) account for less than 1% of GI tumors, but they are the most common mesenchymal neoplasms of the GI tract. (medscape.com)
  • Shown here is a gastric gastrointestinal stromal tumor (GIST). (medscape.com)
  • Treatment protocols for gastrointestinal stromal tumors (GISTs) are provided below, including those for limited-stage disease and persistent or metastatic disease. (medscape.com)
  • A guide for the diagnosis and management of gastrointestinal stromal cell tumors. (medscape.com)
  • Endosonographic features predictive of benign and malignant gastrointestinal stromal cell tumours. (medscape.com)
  • Primary surgery as a frontline treatment for synchronous metastatic gastrointestinal stromal tumors: an analysis of the Kinki GIST registry. (medscape.com)
  • Surgical resection of gastrointestinal stromal tumors after treatment with imatinib. (medscape.com)
  • CXCL12 is also chemotactic for mesenchymal stem cells and is expressed in the area of inflammatory bone destruction, where it mediates their suppressive effect on osteoclastogenesis. (wikipedia.org)
  • IM combined with IR can synergistically inhibit the proliferation, apoptosis, clonogenesis, invasion, migration and cell cycle of GIST cells. (researchsquare.com)
  • GIST-T1 cells in 6-well plates were transfected with 100 pmol of Stealth siRNA (Invitrogen) or a Stealth RNAi Negative Control Medium GC (Invitrogen) using Lipofectamine2000 (Invitrogen). (nih.gov)
  • GIST-T1 cells were maintained in DMEM supplemented with 10% fatal bovine serum. (nih.gov)
  • Results: While thymic stromal lymphopoietin (TSLP) and IL-33 were detected 6 h after RSV infection in the OVA-RSV mice, IL-23 protein was uniquely upregulated in RSV-infected mice alone. (cdc.gov)
  • Ovarian spindle cell lesions: a review with emphasis on recent developments and differential diagnosis. (nih.gov)
  • Ovarian stromal tumors develop in the ovaries' structural connective tissue cells that produce the female hormones estrogen and progesterone. (moffitt.org)
  • however, stromal tumors represent only about 1% of all ovarian cancers. (moffitt.org)
  • This type of cancer is more prevalent in women over the age of 50, but roughly 5% of ovarian stromal tumors form in young girls. (moffitt.org)
  • Because stromal tumors develop in the ovarian cells that produce female hormones, the tumors often end up producing estrogen, which can result in abnormal vaginal bleeding. (moffitt.org)
  • Sometimes, ovarian stromal tumors can actually produce male hormones, which could cause regular menstruation to stop, or superfluous facial and body hair to grow or enlarge the clitoris. (moffitt.org)
  • Moffitt's Gynecologic Oncology Program is home to a multispecialty team of surgeons, medical oncologists, reproductive endocrinologists and many other professionals, who specialize in treating all types of ovarian cancer , including stromal tumors. (moffitt.org)
  • But generally speaking, ovarian stromal tumors are frequently discovered early and can be surgically treated. (moffitt.org)
  • To speak with a Moffitt oncologist specializing in the treatment of ovarian stromal tumors, call 1-888-663-3488 or complete our new patient registration form online. (moffitt.org)
  • The role of Eag and HERG channels in cell proliferation and apoptotic cell death in SK-OV-3 ovarian cancer cell line Cancer Cell International. (nottingham.ac.uk)
  • ADCs and CAR‑Ts could alter the therapeutic framework for refractory cancers, especially diffuse‑type gastric cancer, ovarian cancer and pancreatic cancer with peritoneal dissemination. (spandidos-publications.com)
  • There are three types of ovarian cancers: epithelial ovarian carcinomas, germ cell tumors, and stromal cell tumors. (medlineplus.gov)
  • These are the most common type of ovarian cancer. (medlineplus.gov)
  • Nearly 70% of women with this type of ovarian cancer are diagnosed in the advanced stages. (medlineplus.gov)
  • Teenagers and women in their 20s are more likely to develop this type of ovarian cancer. (medlineplus.gov)
  • Taylor, S , Smith, R & Clegg, P 2009, ' Application of strain to co-cultures of equine tendon fibroblasts and mesenchymal stromal cells decreases tenascin-C and collagen type-V expression ', BSMB Spring Meeting: When, why and how did my cartilage go? (ed.ac.uk)
  • Using real-time, quantitative PCR, laser capture microdissection, and immunohistochemistry, distinctive patterns of expression of the hedgehog pathway members patched 1 (PTCH1), smoothened, GLI1, GLI2 and the 3 hedgehog ligands were identified for epithelial cells and stromal fibroblasts in benign breast and breast cancer. (rti.org)
  • However, cyclopamine reduced viability of cancer epithelial cell lines, including MDA-MB-435, but did not specifically affect fibroblasts or epithelial cells from benign breast, including MCF10AT. (rti.org)
  • Here we examined how V2R signaling within human ccRCC tumor cells (Caki1 cells ) stimulates stromal cancer-associated fibroblasts (CAFs). (bvsalud.org)
  • We found that cell culture conditioned media from Caki1 cells increased activation, migration, and proliferation of fibroblasts in vitro , which was inhibited by V2R gene silencing in Caki1 cells . (bvsalud.org)
  • The MSCs have been described for the first time as colony forming fibroblasts (CFU-F), a rare population of cells residing in the bone marrow of guinea-pigs or mice [ 1 , 2 ]. (hindawi.com)
  • Moreover, both cell types are conserved from mice to humans and colocalize with ILC3 in secondary lymphoid tissues throughout life. (ox.ac.uk)
  • It is ubiquitously expressed in many tissues and cell types. (wikipedia.org)
  • While many studies have demonstrated the importance of cTEC and mTEC during T-cell development, thymic stromal microenvironments also contain heterogenous non-epithelial stromal (NES) populations in a similar manner to that seen in peripheral lymphoid tissues. (frontiersin.org)
  • Recently, MSCs isolated from bone marrow (bmMSCs) were shown to be a blend of distinct cells and MSCs isolated from different tissues show besides some common features also some significant differences. (hindawi.com)
  • These glands and ducts are distributed in the prostate and surrounded by stromal tissues. (jcancer.org)
  • Mass cytometry is particularly well suited to tracking cells in complex tissues because 35+ measurements can be made on each of hundreds of thousands of cells per sample, allowing all cells detected in a sample to be characterized for cell type, signaling activity, and functional outcome 2 . (uib.no)
  • This talk will survey the use of mass cytometry for systems level characterization of cells in healthy human tissues, including blood, bone marrow, and tonsillar tissue, as well as diseases including melanoma, glioblastoma, lymphoma, leukemia, bone marrow failure and myelodysplastic syndromes, and graft vs. host disease. (uib.no)
  • Adipose stromal cells play a key role in releasing estrogens and pro-inflammatory cytokines, while circulating adipose stromal cells (CASCs) home to tumor sites and promote angiogenesis and vascularization. (ku.edu)
  • These findings suggest that evaluation of circulating adipose stromal cells could have value as a response biomarker in weight loss intervention trials of both high risk women and breast cancer survivors. (ku.edu)
  • Mouse (mus musculus) strain C57BL/6J adipose stromal cell culture taken from collagenase digestion of omental fat. (coriell.org)
  • Mononuclear cells were isolated from the non-fasting blood and the frequency of CASCs (characterized as CD34brightCD31-CD45- cells) was assessed by flow cytometry. (ku.edu)
  • Lung outcomes included lung mRNA and protein markers of allergic inflammation, histology for mucus cell metaplasia and lung immune cell influx by cytospin and flow cytometry. (cdc.gov)
  • Comparing HESC controls with HESCs deficient in SRC-3, gene enrichment analysis of the differentially expressed gene set revealed an overrepresentation of genes involved in chromatin remodeling, cell proliferation/motility, and programmed cell death. (frontiersin.org)
  • Within the CNS, CXCL12 contributes to cell proliferation, neurogenesis (nervous tissue development and growth), as well as neuroinflammation. (wikipedia.org)
  • Mesenchymal stromal cells are essential components of hematopoietic stem and progenitor cell (HSPC) niches, regulating HSPC proliferation and fates. (gene-tools.com)
  • Following early observations that MSCs inhibit T-cell proliferation, 9 MSCs were found to interact with the majority of innate and adaptive immune cells. (bmj.com)
  • Multiple myeloma (MM) is an incurable cancer in which uncontrolled plasma cell proliferation disrupts the bone marrow environment and impairs immune function. (hrb.ie)
  • Human bmMSCs were described in the late nineties as well [ 6 ] and at the same time a breakthrough study investigated the expression of typical cell surface markers and the proliferation and differentiation properties of human MSCs in more detail [ 7 ]. (hindawi.com)
  • Many studies have shown that MSCs possess immunosuppression abilities, such as the capacity to inhibit proliferation and functions of many immune cell types. (weizmann.ac.il)
  • A Stromal Cell Niche for Human and Mouse Type 3 Innate Lymphoid Cells. (ox.ac.uk)
  • Lymphoid organs are also home to type 3 innate lymphoid cells (ILC3), innate effector cells essential for barrier immunity. (ox.ac.uk)
  • A novel lineage-tracing approach now identifies a subset of murine fetal lymphoid tissue organizer cells that gives rise exclusively to adult marginal reticular cells. (ox.ac.uk)
  • In sum, we provide evidence that fetal stromal organizers give rise to adult marginal reticular cells and form a dedicated stromal niche for innate ILC3 in adaptive lymphoid organs. (ox.ac.uk)
  • While adult lymphoid progenitor cells are produced by the bone marrow, their lineage commitment and development into mature T-cells is dependent on their migration into the thymus, where essential interactions with heterogeneous thymic stromal cells take place ( 1 ). (frontiersin.org)
  • We employed in vitro cultures and two in vivo models to investigate whether androgens exert these effects directly on marrow lymphoid precursors or whether actions on marrow stromal elements are required. (jci.org)
  • The stromal cell requirement for androgen-mediated effects was confirmed in vivo by experiments using chimeric animals created by bone marrow transplantation in which androgen receptor expression was restricted to either the stromal or lymphoid cells of the bone marrow. (jci.org)
  • OVA-RSV animals varied from RSV- or OVAtreated mice as they had increased lung eosinophils, neutrophils, group 2 innate lymphoid cells (ILC2) and group 3 innate lymphoid cells (ILC3) detectable as early as 6 h after RSV infection. (cdc.gov)
  • 1. To be able to describe the role of innate lymphoid cells (ILCs) in Date of Original Release: April 2014. (cdc.gov)
  • CRTH2: Chemoattractant receptor-homologous molecule expressed includes nonallergic asthma phenotypes, such as asthma on TH2 cells associated with exposure to air pollution, infection, or obesity, ILC: Innate lymphoid cell that require innate rather than adaptive immunity. (cdc.gov)
  • NKT: Natural killer T innate lymphoid cells and their role in asthma. (cdc.gov)
  • Mesenchymal stem/stromal cells (MSCs) obtained from pluripotent stem cells (PSCs) constitute an interesting alternative to classical MSCs in regenerative medicine. (unlp.edu.ar)
  • Among their many mechanisms of action, MSC extracellular vesicles (EVs) are a potential suitable substitute for MSCs in future cell-free-based therapeutic approaches. (unlp.edu.ar)
  • In vitro cell culture and animal studies have demonstrated that mesenchymal stromal cells (MSCs) have the capacity to modify immune responses and to enhance tissue repair. (bmj.com)
  • Mesenchymal stromal cells (MSCs) are cells of non-haematopoietic origin, with the capacity to differentiate into multiple lineages of the mesenchyme, that is, chondrocytes, osteoblasts and adipocytes. (bmj.com)
  • 1 Unique MSC-specific markers have not yet been identified, and MSCs constitute a heterogeneous cell population, including both multipotent (stem) cells and progenitor cells and might even contain pluripotent cell fractions. (bmj.com)
  • 2 MSCs were first described in the bone marrow where they constitute a small fraction of cells (0.001%-0.01%) that closely interact with haematopoietic cells to support haematopoiesis and skeletal homeostasis. (bmj.com)
  • However, transplanting other than hematopoietic stem and progenitor cells is still limited to a few applications, and it mainly applies to mesenchymal stromal cells (MSCs) isolated from bone marrow. (hindawi.com)
  • We therefore briefly discuss differences found in subsets of human bmMSCs and in MSCs isolated from some other sources and touch upon how this could be utilized for cell-based therapies. (hindawi.com)
  • Overview of studies published regarding MSCs using the term "stem cell" or "stromal cell" in the last 20 years accessed by a web search in July 2015 (Google Scholar). (hindawi.com)
  • It seems that the term "stem cell" became more popular although the "stemness" was only shown in a more strict sense for MSCs involved in osteogenesis and bone repair. (hindawi.com)
  • When the biological properties of MSCs were explored in more detail, questions arose whether these cells met the criterion of a true stem cell [ 8 ]. (hindawi.com)
  • Nowadays, experts agree that MSCs may generate upon appropriate stimulation quite different mature cells including osteoblasts, chondrocytes, tenocytes, adipocytes, smooth muscle cells, and stromal cells of the bone marrow [ 9 ]. (hindawi.com)
  • Expansion of MSCs was shown to be limited to a few passages of in vitro culture and the cells underwent replicative senescence [ 11 ]. (hindawi.com)
  • Therefore, available in vitro protocols for expansion of MSCs do not yield true stem cells. (hindawi.com)
  • MSCs were also investigated for stem cell qualities in vivo. (hindawi.com)
  • Mesenchymal stromal cells (MSCs) are widely spread in adult organisms. (weizmann.ac.il)
  • MSCs versus stem cell-based interventions other than MSCs. (lu.se)
  • The goal of this study is to use computational pathology to help guide the development of human-based prognostic H&E biomarker(s) suitable for research and potential clinical use in lung squamous cell carcinoma (SCC). (uzh.ch)
  • The production of a diverse αβ-T-cell pool is vital to establishing and maintaining a functional adaptive immune system. (frontiersin.org)
  • Unlike cells, EVs do not elicit acute immune rejection, and they can be produced in large quantities and stored until ready to use. (unlp.edu.ar)
  • This treatment enhances the immune system and helps it recognize and kill cancer cells. (medicalnewstoday.com)
  • These cancers begin in immune system cells called lymphocytes. (medicalnewstoday.com)
  • I want to calculate immune scores and stromal scores by employing the ESTIMATE algorithm, then analyze the relationship of immune/stromal scores with subtype classification and cytogenetic risk by one-way analysis of variance, but I don't know how to do this! (biostars.org)
  • Objectives Controlled immune responses rely on integrated crosstalk between cells and their microenvironment. (bmj.com)
  • These responses are governed by an evolving milieu of cancer, immune, and stromal cell subpopulations. (uib.no)
  • TLRs are expressed on immune cells, where they recognize pathogenic patterns. (weizmann.ac.il)
  • The integration of pathogen-associated molecular patterns (PAMPs) from microorganisms with their surface receptors in the immune cells, induces the production of several cytokines and chemokines that presents either a pro- and/or anti-inflammatory role by stimulating the secretion of a great variety of antibody subtypes and the activation of mechanisms of controlling the disease, such as the regulatory T cells. (bvsalud.org)
  • Like other chemokines, CXCL12 is involved with cell migration that contributes to inflammation. (wikipedia.org)
  • We started with high-throughput computational image analysis with tissue microarrays (TMAs) to screen for histologic features associated with patient overall survival, and found that features related to stromal inflammation were the most strongly prognostic. (uzh.ch)
  • Based on this, we developed an H&E stromal inflammation (SI) score. (uzh.ch)
  • When germ-free cell cultures became a laboratory routine, hopes were high for using this novel technology for treatment of diseases or replacement of cells in patients suffering from injury, inflammation, or cancer or even refreshing cells in the elderly. (hindawi.com)
  • IL-33, specifically, contributes to these allergic exacerbations by amplifying type 2 inflammation. (cdc.gov)
  • This review summarizes some immunological factors involved in the development and control of this oral disease, such as: the participation of inflammatory cells in local inflammation, the synthesis of chemotaxis proteins with activation of the complement system and a range of antimicrobial peptides, such as defensins, cathelicidin and saposins. (bvsalud.org)
  • Extensive research on thymic epithelial cells (TEC) within the cortex and medulla has defined their essential roles during T-cell development. (frontiersin.org)
  • Arguably, the most recognized and well-studied stromal populations in thymus biology are thymic epithelial cells (TEC) within the cortical and medullary areas, which are defined by their anatomical separation and function. (frontiersin.org)
  • Cortical epithelial cells (cTEC) support the earliest thymocyte progenitor populations, guiding them through the cortex, directing them to a T-cell lineage fate and ensuring their functional qualities as self-MHC restricted cells through the process of positive selection ( 2 ). (frontiersin.org)
  • Medullary epithelial cells (mTEC), in conjunction with dendritic cells, then take over control of developing thymocytes. (frontiersin.org)
  • Hedgehog ligands were expressed at higher levels in some cancer epithelial cell lines compared to noncancerous epithelial cells. (rti.org)
  • Hedgehog-mediated transcription, as indicated by a reporter of GLI-dependent promoter activity and by expression of GLI1 transcripts, was reduced by the hedgehog pathway inhibitor cyclopamine in both MDA-MB-435 cancer epithelial cells and MCF10AT epithelial cells, a cell line derived from benign breast. (rti.org)
  • These results demonstrate modulation of GLI-mediated transcription in both cancer and benign-derived epithelial cells by cyclopamine and sonic hedgehog, and further suggest that hedgehog signaling contributes to the survival of only the cancer epithelial cells. (rti.org)
  • Most human prostate cancers are adenocarcinomas, which originate from the epithelial cells that line the glands and ducts of prostate [ 2 ]. (jcancer.org)
  • The majority of epithelial cells are therefore short-lived, in contrast to a limited number of long-lived stem cells in the base of the crypts. (nature.com)
  • http://dx.doi.org/10.1016/j.jaci.2014.02.015 epithelial cells and airway smooth muscle cells. (cdc.gov)
  • Stromal vascular fraction was isolated from abdominal fat, suspended in α-MEM supplemented with 10% Fetal Bovine Serum and seeded into either T75 flasks or a Quantum system that had been coated with cryoprecipitate. (nih.gov)
  • During embryogenesis, it directs the migration of hematopoietic cells from fetal liver to bone marrow and the formation of large blood vessels. (wikipedia.org)
  • In zebrafish, we previously found that the stromal cells of the caudal hematopoietic tissue (CHT), a niche functionally homologous to the mammalian fetal liver, arise from the ventral part of caudal somites. (gene-tools.com)
  • VM), showed that the recovery of motor functions induced implanted either (1) as a solid piece in the lateral ven- by the grafted fetal dopamine neurons was well cor- tricle6 or a cortical cavity8 adjacent to the denervated related with the extent of graft-derived reinnervation caudate-putamen, or (2) as a crude cell suspension of the host caudate-putamen. (lu.se)
  • In addition to intrathymic selection, and during this medullary residency period, CD4 + and CD8 + single positive (CD4SP, CD8SP) thymocytes acquire the ability to proliferate in response to TCR stimulation, and undergo licensing for cytokine production, prior to exiting the thymus to join the peripheral T-cell pool as Recent Thymus Emigrants (RTE) ( 5 , 6 ). (frontiersin.org)
  • Antibody efficacy in preventing RA synovial cell cytokine release, and in modulating collagen-induced arthritis in rats, was assessed. (bmj.com)
  • Anti-FBG antibodies inhibited cytokine release by RA synovial cells and prevented disease progression and tissue destruction during collagen-induced arthritis. (bmj.com)
  • these antibodies inhibit cytokine release by RA synovial cells and prevent disease progression and tissue destruction during collagen-induced arthritis. (bmj.com)
  • To identify regulators of primitive chronic myeloid leukemia (CML) cells, we performed a high-content cytokine screen using primary CD34 + CD38 low chronic phase CML cells. (haematologica.org)
  • 2 1 There is growing evidence to suggest that primitive CML cells affect the bone marrow (BM) niche, contributing to deregulated cytokine levels. (haematologica.org)
  • Cytokines are essential for the function and maintenance of cells, and altered cytokine levels influence not only leukemic cells, but also the normal HSC within the BM. (haematologica.org)
  • Figure 1 Illustration demonstrating a hypothetical summary of the potential effect of aryl-hydrocarbon receptor activation on multipotent mesenchymal stromal cell function. (wjgnet.com)
  • MSC: Multipotent mesenchymal stromal cell. (wjgnet.com)
  • They display differentiation capacities and therefore qualify as multipotent progenitor cells (Figure 1 ). (hindawi.com)
  • In vitro, these cells have a multipotent phenotype, which manifests as the ability to differentiate into several mesodermal lineages, especially adipocytes, chondrocytes and osteoblasts. (weizmann.ac.il)
  • The C-Kit inhibitor, imatinib mesylate, was administrated to confirm the effect of stromal cells on the tumorigenesis. (jcancer.org)
  • These effects of the stromal cells in the PZ on DU145 cells could be blocked using imatinib mesylate. (jcancer.org)
  • Stromal cell-derived factors 1-alpha and 1-beta are small cytokines that belong to the chemokine family, members of which activate leukocytes and are often induced by proinflammatory stimuli such as lipopolysaccharide, TNF, or IL1. (wikipedia.org)
  • Aberrantly expressed cytokines in the bone marrow (BM) niche are increasingly recognized as critical mediators of survival and expansion of leukemic stem cells. (haematologica.org)
  • Out of the 313 unique human cytokines evaluated, 11 were found to expand cell numbers ≥2-fold in a 7-day culture. (haematologica.org)
  • Stromal tumors may be benign (noncancerous) or malignant (cancerous). (moffitt.org)
  • Thecomas and fibromas are examples of benign stromal tumors. (moffitt.org)
  • KitL, via its receptor cKit, supports primordial germ cell (PGC) growth, survival, migration and reprogramming to pluripotent embryonic germ cells (EGCs). (ca.gov)
  • Ovaries are mostly made of three kinds of cells: epithelial, germ, and stromal. (webmd.com)
  • There's some evidence that Black women are a little more likely to have germ-cell and stromal tumors, compared to other groups. (webmd.com)
  • These cancers grow from germ cells, the cells that make sperm. (medlineplus.gov)
  • Ninety percent of patients with germ cell tumors survive five years after diagnosis. (medlineplus.gov)
  • Stromal tumors of the ovary include germ-cell tumors, sex-cord stromal tumors, and other more rare types. (medscape.com)
  • In adulthood, CXCL12 plays an important role in angiogenesis by recruiting endothelial progenitor cells (EPCs) from the bone marrow through a CXCR4 dependent mechanism. (wikipedia.org)
  • Neural progenitor cells (NPCs) are stem cells that differentiate into glial and neuronal cells. (wikipedia.org)
  • At the same time, by asymmetric cell division or after specific activation, stem cells must be able to generate more mature progenitor cells or differentiated effector cells (Figure 1 ). (hindawi.com)
  • Gene expression down-regulation in CD90+ prostate tumor-associated stromal cells involves potential organ-specific genes. (nih.gov)
  • Dataset analysis was used to compare gene expression between histologically normal and tumor-associated stromal cells. (nih.gov)
  • The tumor-associated stromal cells were found to have decreased expression of genes involved in smooth muscle differentiation, and those detected in prostate but not bladder. (nih.gov)
  • CD90+ prostate tumor-associated stromal cells differed from their normal counterpart in expression of multiple genes, some of which are potentially involved in organ development. (nih.gov)
  • We addressed how treatments and hypoxia affect tumor-associated astrocytes in ways that consequently alter glioma cell properties, and how hypoxia and pseudo-hypoxia are involved in stemness maintenance in glioblastoma. (lu.se)
  • Today, more than 50 years after the first successful bone marrow transplantation, clinical application of hematopoietic stem cells is a routine procedure, saving the lives of many every day. (hindawi.com)
  • In summary, we identify myostatin propeptide as a novel positive regulator of primitive CML cells and corresponding normal hematopoietic cells. (haematologica.org)
  • Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm caused by an acquired 9;22-chromosomal translocation in a hematopoietic stem cell (HSC) resulting in the expression of the BCR-ABL1 fusion protein. (haematologica.org)
  • We also found that SRC-3 depletion in cultured HESCs results in a significant attenuation in the induction of a wide-range of established biomarkers of decidualization, despite exposure of these cells to a deciduogenic stimulus and normal progesterone receptor expression. (frontiersin.org)
  • It has also been shown that CXCL12 signalling regulates the expression of CD20 on B cells. (wikipedia.org)
  • In addition, mTEC screen thymocytes for their expression of high affinity αβ-TCRs, with negative selection limiting the release of these reactive T-cells into the peripheral pool ( 4 ). (frontiersin.org)
  • The expression patterns of stem cell-specific genes of these DU145 cells were examined. (jcancer.org)
  • The purified DU145 cells isolated from the tumors with DU145 and stromal cells in PZ had increased ability to migrate and proliferate, and had increased expression of C-Kit. (jcancer.org)
  • in contrast, the stromal cells in the TZ inhibit it through down-regulating the expression of C-Kit. (jcancer.org)
  • We demonstrate that while Rspo3 from myofibroblasts maintains colonic Lgr5 + cells during homeostasis, during injury its main function is not to maintain Lgr5 + cells but to interact with more differentiated cells that express Lgr4 but not Lgr5 and are able to regain expression of Wnt target genes and generate new crypts. (nature.com)
  • Other differential expression between the stromal cell types included that of the CXC-chemokine genes. (nih.gov)
  • Furthermore, we show expression of MSTN by CML mesenchymal stromal cells, and that myostatin propeptide has a direct and instant effect on CML cells, independent of myostatin, by demonstrating binding of myostatin propeptide to the cell surface and increased phosphorylation of STAT5 and SMAD2/3. (haematologica.org)
  • Whereas pig normal skin displayed a discrete TN-C signal at the dermo-epidermal junction, around blood vessels and hair bulbs, the swine tumour showed enhanced expression of TN-C in these areas and around stromal and tumour cells. (nih.gov)
  • We evaluated cell stemness by using multiple functional assays in combination with stem cell marker expression analysis. (lu.se)
  • In this study, cultivation of ASCs from stromal vascular fraction (SVF) over two passages in the automated and functionally closed Quantum Cell Expansion System (Quantum system) is compared with traditional manual cultivation. (nih.gov)
  • Author Correction: Cellular census of human fibrosis defines functionally distinct stromal cell types and states. (ox.ac.uk)
  • Interactions between tumour cells and surrounding extracellular matrix (ECM) influence the growth of tumour cells and their ability to metastasise. (nih.gov)
  • this may be in part because they have a higher rate of triple-negative breast cancer (negative for estrogen and progesterone receptors and human epidermal growth factor receptor [HER2] oncogene), which has a poorer prognosis than other types. (msdmanuals.com)
  • Once at the site of damage, NPCs may begin stem cell based tissue repair to the lesion. (wikipedia.org)
  • The state of the art in single cell tumor immunology will be discussed, including tissue collection, technical and biological quality controls, analysis of cell signaling (phospho-flow), computational analysis, and integration of different experimental and clinical data types 3 . (uib.no)
  • Mass cytometry is on the leading edge of a new generation of cytomic tools that work with small tissue samples, such as a fine needle aspirates or blood draws, to monitor changes in rare or unexpected cell subsets during cancer therapy. (uib.no)
  • The 3D-perfusion system generated a stromal tissue that could be enzymatically treated to yield CD45- MSC. (unibas.ch)
  • Stem cell-based therapies offer a potential therapeutic approach to repair, restore, or regenerate injured brain tissue. (lu.se)
  • To qualify as a stem cell, these cells must be able to self-renew, most likely by symmetric cell division to produce two daughter cells with the same stem cell qualities. (hindawi.com)
  • Overview on self-renewal or differentiation of stem cells in their respective stem cell niche. (hindawi.com)
  • The model will be useful for understanding the mechanisms by which the prostatic stem cell niche controls the tumorigeneis of prostatic cancer stem cells. (jcancer.org)
  • Signals that regulate epithelial regeneration upon stem cell injury are largely unknown. (nature.com)
  • Rspo proteins are secreted and can stabilize the effects of Wnt ligands by preventing ubiquitination and turnover of the Wnt receptor frizzled 9 , thereby dictating the size of the Lgr5 + stem cell pool by regulating self-renewal of Lgr5 + cells 10 . (nature.com)
  • We have shown that in the stomach, stem cell homeostasis is regulated by Wnt and Rspo secreted by stromal myofibroblasts 11 . (nature.com)
  • Mesenchymal stromal/stem cell (MSC) expansion in conventional monolayer culture on plastic dishes (2D) leads to progressive loss of functionality and thus challenges fundamental studies on the physiology of skeletal progenitors, as well as translational applications for cellular therapy and molecular medicine. (unibas.ch)
  • Objectives: To evaluate the benefits and harms of stem cell-based interventions for prevention or treatment of GM-IVH and EoP in preterm infants. (lu.se)
  • Mesenchymal stromal cells create and maintain specialized niches that support survival, activation, and expansion of T and B cells, and integrated analysis of lymphocytes and their niche has been instrumental in understanding adaptive immunity. (ox.ac.uk)
  • Stimulation of hedgehog signaling induces carcinogenesis or promotes cell survival in cancers of multiple organs. (rti.org)
  • The results presented here describe a dramatic alteration of the ECM composition in swine malignant melanoma which might have a large influence on tumourigenesis or invasion and metastasis of melanoma cells. (nih.gov)
  • However, a specialized stromal niche for ILC3 has not been identified. (ox.ac.uk)
  • About 85% to 90% of these cancers start in the cells that cover the outer surface of the ovary. (medlineplus.gov)
  • We show here that, like SRC-2, SRC-3 is expressed in the epithelial and stromal cellular compartments of the human endometrium during the proliferative and secretory phase of the menstrual cycle as well as in cultured HESCs. (frontiersin.org)
  • These clinical cell biology insights have paralleled advances in single cell technology and sparked intense study of the cellular mechanisms driving therapy response and resistance 1 . (uib.no)
  • 3 Irish, J. M. & Doxie, D. B. High-dimensional single-cell cancer biology. (uib.no)
  • By contrast, somatic alterations in the genes encoding Notch signaling components drive various types of human cancer, such as breast cancer, small-cell lung cancer (SCLC) and T-cell acute lymphoblastic leukemia (T-ALL) ( 6 - 9 ). (spandidos-publications.com)
  • Here we demonstrate that 2D MSC expansion can be entirely bypassed by culturing freshly isolated bone marrow nucleated cells within 3D porous scaffolds in a perfusion-based bioreactor system. (unibas.ch)
  • We have now found that this ventral domain is the sclerotome, and that two markers of mammalian mesenchymal stem/stromal cells, Alcam and Pdgfr-α, are distinctively expressed there and instrumental for the emergence and migration of stromal cell progenitors, which in turn conditions the proper assembly of the vascular component of the CHT niche. (gene-tools.com)
  • Moreover, we showed that p75 NTR signaling is involved in the activation of the hypoxic signaling pathway and is also regulating glioma cell stemness and migration in hypoxia. (lu.se)
  • We showed that the generation of the cleaved form of the cell surface glycoprotein CD44 leads to the stabilization of the HIFs in the perivascular and the perinecrotic glioma niche, leading to increased hypoxic signaling and glioma cell stemness. (lu.se)
  • We previously demonstrated the critical involvement of SRC-2 in murine embryo implantation as well as in human endometrial stromal cell (HESC) decidualization, a cellular transformation process required for trophoblast invasion and ultimately placentation. (frontiersin.org)
  • The thymus supports T-cell development via specialized microenvironments that ensure a diverse, functional and self-tolerant T-cell population. (frontiersin.org)
  • These microenvironments are classically defined as distinct cortex and medulla regions that each contain specialized subsets of stromal cells. (frontiersin.org)
  • Significantly, there are additional non-epithelial stromal cells (NES) that exist alongside TEC within thymic microenvironments, including multiple subsets of mesenchymal and endothelial cells. (frontiersin.org)
  • Stomach cancer, or gastric cancer, begins when cells change and grow out of control. (medicalnewstoday.com)
  • This has been studied mainly in the small intestine, where different cell types such as enterocyte progenitors 4 , more differentiated secretory Bmi1 + cells 3 , or even fully differentiated Paneth cells can repopulate crypts upon injury. (nature.com)