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Nucleic Acid HybridizationRNA, MessengerBase SequenceDNARNARNA, Small InterferingRNA, ViralRNA EditingRNA SplicingRNA, RibosomalGene Transfer TechniquesRNA, BacterialRNA, TransferDNA-Directed RNA PolymerasesRNA InterferenceRNA VirusesGene Transfer, HorizontalEmbryo TransferMolecular Sequence DataRNA, Double-StrandedRNA, CatalyticRNA FoldingRNA Polymerase IIAmino Acid SequenceRNA, FungalNG-Nitroarginine Methyl EsterNucleic Acid ConformationRNA StabilityRNA HelicasesRNA, AntisenseKineticsRNA, Transfer, ArgRNA Processing, Post-TranscriptionalTransfer (Psychology)ArginineMethyl ParathionEscherichia coliRNA PrecursorsMutationFluorescence Resonance Energy TransferRNA, Small NuclearRNA, UntranslatedModels, MolecularRNA CapsBinding SitesSequence Analysis, RNARNA, PlantAdoptive TransferGenetic VectorsMethyl MethanesulfonateRNA, ProtozoanProtein BindingPatient TransferPhospholipid Transfer ProteinsPlasmidsRNA, NeoplasmCell LineRNA Ligase (ATP)Transfer FactorDEAD-box RNA HelicasesConjugation, GeneticMethyl ChlorideElectron TransportRNA Polymerase IIIMethylationSubstrate SpecificityCholesterol Ester Transfer ProteinsNuclear Transfer TechniquesRNA Polymerase IRNA, NuclearCatalysisMutagenesis, Site-DirectedBacterial ProteinsRNA, GuideRecombinant ProteinsRNA, Ribosomal, 28SProtein ConformationProtein Structure, TertiaryRNA, Ribosomal, 16STime FactorsStructure-Activity RelationshipTendon TransferGenetic TherapyTransfectionRNA-Binding ProteinsSequence Homology, Amino AcidRNA, Ribosomal, 23SRNA, Ribosomal, 18SDNA PrimersTranscription, GeneticCells, CulturedMethyltransferasesProtein BiosynthesisPhylogenyCarrier ProteinsOxidation-ReductionAdenoviridaeMagnetic Resonance SpectroscopyMolecular StructureRNA Transport

ImmunoprecipitationMethylationEnzymesPathogensModificationFunctional rolesProteinSecretionVirusesNitrogenPRMT1ProteinsModificationsArginineGeneCommonFamilyPotentialIncludesStudyTRNAPolymeraseHistoneInterproscanPeptideMotifCellularTerminalSpeciesTranscriptionCell typesFoundPrimary

Immunoprecipitation2

• High-throughput sequencing refers to the use of antibody immunoprecipitation or chemical methods to accurately locate the site of m7G modification in RNA. (beds.ac.uk)
• STAG3 N6-methyladenosine (m6A) modification level were identified using m6A RNA immunoprecipitation (MeRIP). (bvsalud.org)

Methylation7

• In particular, certain types of ALKBH enzymes are dioxygenases that directly reverse DNA methylation damage via transfer of a methyl group from the DNA adduct onto α-ketoglutarate and release of metabolic products including succinate and formaldehyde. (frontiersin.org)
• Protein methylation is a type of post-translational modification featuring the addition of methyl groups to proteins. (wikipedia.org)
• Protein methylation has been most studied in histones, where the transfer of methyl groups from S-adenosyl methionine is catalyzed by histone methyltransferases. (wikipedia.org)
• For some types of methylation, such as N-terminal methylation and prenylcysteine methylation, additional processing is required, whereas other types of methylation such as arginine methylation and lysine methylation do not require pre-processing. (wikipedia.org)
• Methylation of arginine residues is catalyzed by three different classes of protein arginine methyltransferases (PRMTs): Type I PRMTs (PRMT1, PRMT2, PRMT3, PRMT4, PRMT6, and PRMT8) attach two methyl groups to a single terminal nitrogen atom, producing asymmetric dimethylarginine (N G,N G-dimethylarginine). (wikipedia.org)
• Epigenetics refers to heritable changes in gene expression without changing the nucleotide sequence of the gene, including DNA methylation, histone modifications, and RNA modifications. (beds.ac.uk)
• Arginine methylation is a type of post-translational modification that produces monomethylated or dimethylated arginine residues. (molcells.org)

Enzymes2

• Direct DNA repair comprises several types of DNA repair enzymes that reversibly remove alkyl groups from damaged DNA bases through oxidative dealkylation processes. (frontiersin.org)
• Ubiquitination is performed sequentially by three types of enzymes. (molcells.org)

Pathogens1

• IMPORTANCE The immune system must be able to tailor its response to different types of pathogens in order to eliminate them and protect the host. (biomed.news)

Modification3

• M7G modification, known as one of the common post-transcriptional modifications of RNA, is present in many different types of RNAs. (beds.ac.uk)
• With the rapid development of sequencing technology, m7G has become a new research hotspot of RNA modification. (beds.ac.uk)
• comfirmed the existence of m7G inside mammalian mRNA for the first time and pioneered the invention of a new type of epigenetic sequencing method (m7G-seq) to reveal the distribution sites of m7G modifications [ 11 ], which laid the foundation for the related research of m7G subsequent modification. (beds.ac.uk)

Functional roles1

• With the accurate identification of m7G modifications within RNAs, their functional roles in the regulation of gene expression and different physiological functions have been revealed. (beds.ac.uk)

Protein5

• Finally, we discovered two kinds of strain-typing protein-encoding genes, i.e., the SAM-dependent methyltransferase and electron transport complex subunit RsxC. (bvsalud.org)
• RNA methyltransferase nucleolar protein p120 (NOP2), commonly referred to as NOP2/Sun RNA methyltransferase family member 1 (NSUN1), is involved in cell proliferation and is highly expressed in various cancers. (bvsalud.org)
• Preexisting antivector immunity can severely compromise the ability of Salmonella enterica serovar Typhimurium live vaccines to induce protective CD8 T-cell frequencies after type III secretion system-mediated heterologous protein translocation in orally immunized mice. (cipsm.de)
• Description: A sandwich ELISA kit for detection of Protein Tyrosine Phosphatase, Non Receptor Type 11 from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (worldcarecouncil.org)
• Description: A sandwich quantitative ELISA assay kit for detection of Human Protein Tyrosine Phosphatase, Non Receptor Type 11 (PTPN11) in samples from tissue homogenates or other biological fluids. (worldcarecouncil.org)

Secretion1

• Here we demonstrate that microbial small RNAs (msRNA) are enriched on low-density lipoprotein (LDL) and drive pro-inflammatory macrophage polarization and cytokine secretion via activation of the RNA sensor toll-like receptor 8 (TLR8). (biomed.news)

Viruses1

• RNA is the genetic material in some viruses. (bankofbiology.com)

Nitrogen1

• In contrast, type II PRMTs (PRMT5 and PRMT9) catalyze the formation of symmetric dimethylarginine with one methyl group on each terminal nitrogen (symmetric N G,N' G-dimethylarginine). (wikipedia.org)

PRMT11

• Among the type I PRMT family, only PRMT1 showed activity for Smurf2. (molcells.org)

Proteins2

• In interactions of proteins with nucleic acids, arginine residues are important hydrogen bond donors for the phosphate backbone - many arginine-methylated proteins have been found to interact with DNA or RNA. (wikipedia.org)
• Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. (thermofisher.com)

Modifications2

• Molecular formula of common RNA modifications. (beds.ac.uk)
• The detection of RNA modifications is fundamental to the study of m7G modifications in the regulation of gene expression. (beds.ac.uk)

Arginine1

• PRMT7, the only known type III PRMT, produces only monomethylated arginine. (wikipedia.org)

Gene1

• Here, we used a gene therapy approach to directly overexpress APPsα in the brain using AAV-mediated gene transfer and explored its potential to rescue structural, electrophysiological and behavioral deficits in APP/PS1∆E9 AD model mice. (springer.com)

Common1

• The meteorite, believed to be about 4.5 billion years old and weighing 1.9 kg (4.2 lb), had initially been classified as a diogenite, a common type of rock. (mathisfunforum.com)

Family1

• Like other members of the Rel family of transcriptional activators, NF-κB is sequestered in an inactive form in the cytoplasm of most cell types. (justia.com)

Potential1

• Human pluripotent stem cells can be expanded virtually unlimitedly and have the potential to differentiate into any cell types, thus making them a promising source for β-cells. (wustl.edu)

Includes1

• It includes Cytosine (C), Thymine (T-only in DNA) & Uracil (U-only in RNA). (bankofbiology.com)

Study1

• This study was undertaken to explore the contribution of PDCs and type I IFNs to RA pathogenesis using various animal models of PDC depletion and to monitor the effect of localized PDC recruitment and activation on joint inflammation and bone damage. (cnrs.fr)

TRNA2

• Transfer RNA (tRNA) is present at tens of millions of transcripts in a human cell and is the most abundant RNA in moles among all cellular RNAs. (nih.gov)
• tRNA is also the most extensively modified RNA with, on an average, 13 modifications per molecule. (nih.gov)

Polymerase2

• This is required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination (PubMed:26700805). (assaygenie.com)
• The ReViTA system uses a plasmid with a control sequence, the promoter region of the studied gene, the transcription factor of interest, and an RNA polymerase saturated with σ70. (ibecbarcelona.eu)

Histone2

• Methylates histone H2A and H4 'Arg-3' during germ cell development. (assaygenie.com)
• Methylates histone H3 'Arg-8', which may repress transcription. (assaygenie.com)

Interproscan1

• UvrD/REP helicase N-terminal domain, UvrD-like helicase C-terminal domain, DNA helicase IV / RNA helicase N terminal [Interproscan]. (ntu.edu.sg)

Peptide1

• Mass spectrometry analysis showed that a C-terminal peptide (Val 327 - Asn 356 ) was present in Nit-ANigRec but missing in Nit-ANigWT and Asp 298 -Val 313 peptide was shortened to Asp 298 -Arg 310 in Nit-ANigWT. (biomedcentral.com)

Motif1

• The PAI-vitronectin complex binds to the Arg-Gly-Asp motif of αv integrins and inhibits the integrin-mediated cell migration [ 28 - 33 ]. (biomedcentral.com)

Cellular2

• Secondly, the integration rate depended on cell types and cellular states. (nature.com)
• Metabolic channeling offers unique opportunities for enhancing and regulating cellular biochemistry and major advantage of such spatial organization is the transfer of biosynthetic intermediates between catalytic sites without diffusion into the bulk phase of the cell [14]. (scirp.org)

Terminal2

• In contrast, type II PRMTs (PRMT5 and PRMT9) catalyze the formation of symmetric dimethylarginine with one methyl group on each terminal nitrogen (symmetric N G,N' G-dimethylarginine). (wikipedia.org)
• The smallest and most extensively studied member, CpGH84C, comprises an N-terminal catalytic domain with beta-N-acetylglucosaminidase activity, a family 32 carbohydrate-binding module, a family 82 X-module (X82) of unknown function, and a fibronectin type-III-like module. (embl-heidelberg.de)

Species1

• HN - 2020 BX - 1-Methyl-1-phenylethylene Derivatives BX - 1-Phenyl-2-propene Derivatives BX - 2-Propenylbenzene Derivatives BX - 3-Ethenylmethylbenzene Derivatives BX - Allylbenzenes BX - Vinyl Toluene Derivatives FX - Stilbenes MH - Alouatta caraya UI - D000080532 MN - B1.50.150.900.649.313.988.400.600.75.50.75.500 MS - A species of the genus ALOUATTA, family ATELIDAE, inhabiting the forests of South America. (nih.gov)

Transcription1

• After the promoters were incubated with the transcription factors, the plasmid was transcribed into RNA and reverse transcribed to cDNA. (ibecbarcelona.eu)

Cell types3

• The beta isoform of actin, along with gamma actin, coexist in most cell types as components of the cyto-skeleton. (thermofisher.com)
• Inducible NOS is expressed in many cell types in response to a diverse range of inflammatory cytokines, including IL-1β, IL-2, IFN-γ, TNF-α, and bacterial metabolites such as LPS ( 4 , 5 , 6 ). (aai.org)
• Like other members of the Rel family of transcriptional activators, NF-κB is sequestered in an inactive form in the cytoplasm of most cell types. (justia.com)

Found3

• In an in vitro yeast-based estrogen assay, the four most widely used parabens (namely methyl-, ethyl-, propyl-, and butylparaben) were all found to be weakly estrogenic with the most potent (butylparaben) being 10,000-fold less potent than 17 beta-estradiol. (researchgate.net)
• They found that sustentacular cells are the major target cell type in the olfactory mucosa, but failed to find evidence for infection of olfactory sensory neurons. (covidreference.com)
• While these organic compounds are commonplace, found throughout the solar system, the PAHs in the meteorite were unusual in appearance, resembling the type that result from the decay of organic matter. (mathisfunforum.com)

Primary1

• Plasminogen activator inhibitor type 1 (PAI-1) is the primary inhibitor of urokinase type plasminogen activators (uPA) and tissue type plasminogen activators (tPA), which mediate fibrinolysis. (biomedcentral.com)