Types 1994 activity of interleukin 1 receptors interleukin 1 type ii. Medical search. Frequent questions

Finally, to address the functional role of this cytokine, we measured the effect of human recombinant (hr)IL-1β on seizure activity as one marker of the response to kainate. (jneurosci.org)
Interleukin 2 (IL-2) is a pleiotropic cytokine produced primarily by mitogen- or antigen-activated T lymphocytes (1, 2). (abscitech.com)
Goldsmith, M.A. and W.C. Greene (1994) in The Cytokine Handbook, 2nd ed. (abscitech.com)
IL-17A, the original member of the IL-17 cytokine family, was first identified in 1993 and was initially recognized for its similarity to a sequence belonging to the open reading frame 13 of Herpesvirus saimiri (HVS13) [ 1 , 2 ]. (hindawi.com)
Structurally, the IL-17 cytokine family members have no sequence similarity to any other known cytokine or other mammalian proteins [ 2 ]. (hindawi.com)
Similarly, the IL-17 receptor family (IL-17RA-RE) is not related to any of the other known cytokine receptors [ 2 ]. (hindawi.com)
Thus, the IL-17 cytokine family appears to represent a distinct ligand-receptor signaling system. (hindawi.com)
Interleukin-6 (IL-6) is a multifunctional cytokine that regulates pleiotropic roles in immune regulation, inflammation, hematopoiesis, and oncogenesis. (sbhsciences.com)
BMP-7, also called osteogenic protein-1, is a member of the TGF-β superfamily of cysteine-knot fold cytokine-growth factors [ 18 ] . (encyclopedia.pub)
Babin-Ebell J, Misoph M, Müllges W, Elert O. Cytokine release during cardiopulmonary bypass related to roller / centrifugal pumps: effect of pump-type on cytokine release. (2medicalcare.com)
Cytokine 2002;19(2):55-8. (2medicalcare.com)
In the context of AP, the most extensively investigated chemokines are CC-ligand 2 (CCL2, also known as monocyte chemoattractant protein-1 or MCP-1), CXC-ligand 1 (CXCL1, also known as cytokine-induced neutrophil chemoattractant or CINC in rat and keratinocyte cytokine or KC in mouse), and CXC-ligand 2 (CXCL2, also known as macrophage inflammatory protein 2-alpha or MIP2a). (pancreapedia.org)
2 1 There is growing evidence to suggest that primitive CML cells affect the bone marrow (BM) niche, contributing to deregulated cytokine levels. (haematologica.org)
Interleukin 15 (IL-15), a four-helix bundle cytokine, is involved in a plethora of different cellular functions and, particularly, plays a key role in the development and activation of immune responses. (bvsalud.org)
Interleukin-15 (IL-15), a 114-amino acid cytokine related to IL-2, regulates immune homeostasis and the fate of many lymphocyte subsets. (bvsalud.org)
matory response, IL-10 has been shown to inhibit macrophage and Chronic beryllium disease (CBD) provides a human disorder in T lymphocyte cytokine synthesis and MHC class II and B7 ex- which to study the delayed type hypersensitivity response to persistent pression. (cdc.gov)

Various cell types can process and present these antigens to T cells, or antigens may be soluble and bound to B-cell receptors. (medscape.com)

C-X-C chemokine receptor 2 (CXCR2) is a chemotactic receptor that is critical in neutrophil mobilization from bone marrow to blood and tissue sites. (frontiersin.org)
Although a defect in the chemokine receptor CX3CR1 increases susceptibility of mice and humans to systemic candidiasis, it does not in mucosal candidosis. (medscape.com)

4 In the ARC, there are two distinct neuronal populations: one group of neurons produces the orexigenic neuropeptides neuropeptide Y (NPY) and agouti-related peptide (AgRP), whereas the other subset of neurons expresses the anorexigenic neuropeptides proopiomelanocortin (POMC), and cocaine- and amphetamine-regulated transcript. (nature.com)
The functional high-affinity receptor for IL-2 is composed of three distinct polypeptide chains (7, 8). (abscitech.com)
Recently, two distinct TNF receptors with molecular weights of 55 kDa (TNFR55) and 75 kDa (TNFR75) have been cloned and characterized. (ox.ac.uk)

IL-2 is a potent lymphoid cell growth factor which exerts its biological activity primarily on T cells promoting proliferation and maturation. (abscitech.com)
Its biological activities are shared by IL-6-family of cytokines such as leukemia inhibitory factor and oncostatin M. IL-6 exerts its biological activities through interaction with specific receptors expressed on the surface of target cells. (sbhsciences.com)

These receptors trigger inflammation through the NFkB-dependent and interferon regulatory factor-dependent signaling pathway. (medscape.com)
IL-17F is expressed in activated CD4 + T cells, basophils, and mast cells, three important cell types involved in allergic airway inflammation [ 3 ]. (hindawi.com)
In addition, chronic diagnostic test for follow-up of patients cy and for biochemical determination inflammation associated with the infec- with H. pylori gastritis and were able of tissue COX-2 activity using COX tion leads to damage in proteins, the to predict the risk of development of Activity Assay Kit (Cayman Chemical production of reactive oxygen species stomach cancer. (who.int)
It is involved in various metabolic processes, such as acting on white adipose tissue to upregulate brown adipose tissue-specific genes, enhancing PGC-1α expression to increase lipid oxidation, suppressing inflammation in skeletal muscles, inhibiting cardiometabolic risk factors, and suppressing endoplasmic reticulum stress in hepatoblastoma cells. (encyclopedia.pub)
Chronic inflammation is connected to neoplastic transformation, and it is known that patients with autoimmune diseases have increased risks for some types of tumors [ 3 , 4 ], with neoplastic transformation often occurring [ 5 - 8 ]. (medsci.org)

We have recently identified, for the first time, that bronchial epithelial cells are its novel cell source in response to IL-33 via ST2-ERK1/2-MSK1 signaling pathway. (hindawi.com)

Static magnetic fields generated by a 0.5 T MRI unit affects in vitro expression of activation markers and interleukin release in human peripheral blood mononuclear cells (PBMC) [med. (emf-portal.org)
Furthermore, we describe the involvement of the two TNF receptors in signaling in vitro hematopoietic effects of TNF-α. (ox.ac.uk)

Another mechanism whereby injured pancreatic acinar cells trigger the inflammatory response is through synthesis and release of cytokines (36) and chemokines (11), and upregulation of adhesion molecules such as the intercellular adhesion molecule-1 (ICAM-1) (136), which together promote neutrophil and monocyte infiltration (27, 71) and exacerbate tissue injury (10, 27, 37). (pancreapedia.org)

In sum, our data indicate that IL-1β is a key molecular mediator that communicates between gastro-intestinal tract (i.e. site of CDI) and bone marrow (i.e. primary neutrophil reservoir) and regulates the intensity of CDI-induced tissue neutrophilia by modulating CXCR2 expression. (frontiersin.org)
BAIBA (C 4 H 9 NO 2 ) is a small, non-protein myokine with a molecular weight of 103.6 Da that was first discovered in human urine in 1951 [ 11 ] . (encyclopedia.pub)
1. NIHR Liverpool Pancreas Biomedical Research Unit and Department of Cellular and Molecular Physiology, University of Liverpool, UK. (pancreapedia.org)
The study aims to explore the active molecules of traditional Chinese medicine that specifically bind to interleukin-15 receptor α (IL-15Rα) using molecular docking and surface plasmon resonance (SPR) technology. (bvsalud.org)
Here we present the results of molecular dynamics simulations carried out on four relevant forms of IL-15: its monomer, IL-15 interacting individually with IL-15Rα (IL-15/IL-15Rα), with IL-2Rß/Î³c subunits (IL-15/IL-2Rß/Î³c) or with its three receptors simultaneously (IL-15/IL-15Rα/IL-2Rß/Î³c). (bvsalud.org)
The integration of pathogen-associated molecular patterns (PAMPs) from microorganisms with their surface receptors in the immune cells, induces the production of several cytokines and chemokines that presents either a pro- and/or anti-inflammatory role by stimulating the secretion of a great variety of antibody subtypes and the activation of mechanisms of controlling the disease, such as the regulatory T cells. (bvsalud.org)

The adaptive immune system consists of 2 types of lymphocytes: T cells (70-75% of the adaptive immune force) and B cells (10-20% of the adaptive immune force). (medscape.com)
Extremely low frequency pulsed electromagnetic fields increase interleukin-2 (IL-2) utilization and IL-2 receptor expression in mitogen-stimulated human lymphocytes from old subjects [med. (emf-portal.org)

This effect was blocked by coinjection of 1 μg (hr)IL-1β receptor antagonist or 0.1 ng of 3-((+)-2-carboxypiperazin-4-yl)-propyl-1-phosphonate, selective antagonists of IL-1β and NMDA receptors, respectively. (jneurosci.org)
Moreover, this variant is a natural antagonist for the wild-type IL-17F. (hindawi.com)
The results showed that neoprzewaquinone A (Neo) possessed the highest specific binding affinity among the active molecules from traditional Chinese medicine, and the dissociation constant (KD) value was (0.62 ± 0.20) µmol/L. The results of cell experiment showed that Neo significantly inhibited the proliferation of Mo7e cells induced by IL-15, and the IC50 was 1.075 µmol/L, approximately 1/120 of the IC50 of Cefazolin (IL-15 specific antagonist). (bvsalud.org)

We have previously reported that a single nucleotide polymorphism (SNP) in leptin receptor (LEPR), present in up to 50% of people, influenced CDI-induced neutrophil CXCR2 expression and tissue neutrophilia. (frontiersin.org)
and d) IL-1β neutralization reduced CXCR2 expression on bone marrow and blood neutrophils and their subsequent accrual to colonic tissue. (frontiersin.org)
bronchoalveolar lavage cells from control and CBD subjects to evaluate the beryllium salt-specific production of endogenous IL-10 and the effects of exogenous human rIL-10 (rhIL-10) on HLA expression, on the production of IL-2, IFN- , and TNF- , and on T lymphocyte proliferation. (cdc.gov)

Recently, cytokines and their receptors have been located in many other tissues, including the peripheral and central nervous systems ( Hopkins and Rothwell, 1995 ). (jneurosci.org)
[ 1 ] Neutrophils move to the site of invasion by means of chemotaxis, which occurs in response to microbial products, activated complement proteins, and cytokines. (medscape.com)
Specifically, TNF-α is a potent inhibitor of the clonal growth of primitive and committed murine and human bone marrow progenitors in combination with multiple cytokines, including granulocyte colony-stimulating factor (G-CSF), CSF-1, erythropoietin (Epo), stem cell factor (SCF), and flt3 ligand (FL). (ox.ac.uk)
Chemokines (chemotactic cytokines) are positively charged polypeptides with highly conserved cysteine (C) residues within the N-terminal sequence, classifying them as 'C', 'CC', 'CXC' or 'CX3C' types (102, 143). (pancreapedia.org)
Out of the 313 unique human cytokines evaluated, 11 were found to expand cell numbers ≥2-fold in a 7-day culture. (haematologica.org)
3 In CML, several pro-inflammatory cytokines, such as IL-6, 5 4 IL-1β, 6 and TNF-α, 4 have been shown to be up-regulated in patient serum. (haematologica.org)
IL-15 forms receptor complexes by binding with IL-2Rß- and common Î³(Î³c)-signaling subunits, which are shared with other members of the cytokines family (IL-2 for IL-2Rß- and all other Î³c- cytokines for Î³c). (bvsalud.org)
Progression of this disease occurs due to a combination of factors, including the presence of periodontopathic bacteria, high levels of proinflammatory cytokines, matrix metalloproteinases (MMPs), prostaglandin E2 (PGE2), low levels of anti-inflammatory cytokines including inter- leukin-10 (IL-10), transforming growth factor (TGF- β ) and tissue inhibitors of MMPs (TIMPs) (2,3). (bvsalud.org)

Intrahippocampal application of 0.77 nmol of bicuculline methiodide, which induces EEG seizures but not cell loss, enhanced IL-1β immunoreactivity and microglia, although to a less extent and for a shorter time compared with kainate. (jneurosci.org)
and induces the proliferation and differentiation of oligodendrocytes (1, 2). (abscitech.com)

Inhibition of experimental autoimmune neuritis by an antibody to the lymphocyte function-associated antigen-1. (2medicalcare.com)
CMIR)3 and, in the presence of persistent Ag, in the stricted, beryllium salt-specific T lymphocyte proliferation (1-3). (cdc.gov)

The two recognized types of immunity are innate and adaptive. (medscape.com)
Interleukin-15 (IL-15) can promote both innate and adaptive immune reactions by stimulating CD8+/CD4+ T cells and natural killer cells (NK) while showing no effect in activating T-regulatory (Treg) cells or inducing activation-associated death among effector T cells and NK cells. (bvsalud.org)

Whole-genome sequencing revealed 2 dominant serotypes-emm3 and emm6-with high rates of mucoid phenotype and systemic bacteremia. (cdc.gov)

Defective crosstalk between the brain and peripheral organs contributes to the development of obesity and type 2 diabetes. (nature.com)
In this study production levels of interleukins (IL)-12 and IL-13 were measured by commercial ELISA in culture supernatants of mitogen-stimulated peripheral blood mononuclear cells from 30 non-splenectomized beta- thalassaemia cases with iron overload and 20 age- and sex-matched healthy individuals. (who.int)

Conclusions: We document a significant but transient increase in iGAS disease incidence in 2 months of 2017. (cdc.gov)

10 8 By contrast, chronic exposure to IL-1 leads to exhaustion of normal HSC. (haematologica.org)
Chronic beryllium disease (CBD) provides a human disorder in which to study the delayed type IV hypersensitivity response to persistent Ag that leads to noncaseating pulmonary granuloma formation. (cdc.gov)
By tradition, the most commonly used classification of oral candidosis divides the infection into 4 types including (1) acute pseudomembranous candidosis (thrush), (2) acute atrophic (erythematous) candidosis, (3) chronic hyperplastic candidosis, and (4) chronic atrophic (erythematous) candidosis. (medscape.com)
Chronic hyperplastic candidosis was further subdivided into 4 groups based on localization patterns and endocrine involvement including (1) chronic oral candidosis (candidal leukoplakia), (2) endocrine candidosis syndrome, (3) chronic localized mucocutaneous candidosis, and (4) chronic diffuse candidosis. (medscape.com)

This type of activation, called "trans-signalling", renders virtually all cells capable of responding to IL-6/sIL-6R alpha complexes, making for a large new spectrum of IL-6 activities, ranging from the control of the immune response to involvement in pathological states. (sbhsciences.com)

Here we show that two representative Phox homology (PX) domains selectively bind to specific phosphatidylinositol phosphates. (embl.de)

IL-6 Receptor (IL-6R, gp80) is 80 kDa alpha subunit, transmembrane glycoprotein that is 449 aa long. (sbhsciences.com)

5 The anorexigenic effect of monoamine serotonin is also mediated by the 5HT-2C receptor in POMC neurons. (nature.com)

8(1): 7675, 2018 05 16. (bvsalud.org)
Tel.: +1 773 325 2018. (cdc.gov)

Human apelin was identified and isolated in 1998 as an endogenous ligand of the G-protein-coupled receptor APJ and was named the APJ endogenous ligand. (encyclopedia.pub)

The biological effects of IL-2 are mediated by specific cell surface receptor complexes. (abscitech.com)

The generation of receptors specific for antigens is a unique and complex process that generates 10 12 specific receptors for each cell type of the adaptive immune system, including T and B cells. (medscape.com)
Whereas human IL-2 is active on mouse cells, mouse IL-2 is species-specific and is inactive on human cells. (abscitech.com)
It is secreted by contracting muscles via the action of peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) and acts in a myokine-specific manner [ 12 ] [ 13 ] . (encyclopedia.pub)
They are part of a much larger group of compounds, the eicosanoids, which, although ubiquitous as a group, are produced by a variety of cell type-, tissue-, and species-specific biosynthetic pathways. (jci.org)
At their best, they usually rely on some mysterious things called ionic pumps, that perform active transport, powered by little motors, under instructions from molecules that act on their specific receptors. (raypeat.com)
Members of a subfamily of these enzymes share a specific domain that was first identified in the yeast Sac1 protein [1]. (embl.de)
Some of the prepared cyclitol derivatives (i.e. 9, 11, 12, and 14) proved to be very powerful and specific irreversible inhibitors of PI4K230 at or below a concentration of 1 mM. (embl.de)
Acute radiation syndromes can be caused by a sufficient dose of some internally deposited radionuclides that are widely distributed in tissues and organs and have a high specific activity. (msdmanuals.com)
For example, polonium-210 (Po-210) has a specific activity of 166 terabecquerels per gm (TBq/g), and 1 mcg (about the size of a grain of salt) of Po-210 delivers a whole body dose of 50 Sv (~20 times the median lethal dose). (msdmanuals.com)

Because the biological availability and toxicity of strontium are primarily related to the strontium(II) oxidation state, ATSDR (2001e) has focused on that form of strontium. (cdc.gov)

Effects of short term exposure to 60 Hz electromagnetic fields on interleukin 1 and interleukin 6 production by peritoneal exudate cells [med. (emf-portal.org)
1% after 6 hours of exposure, while absorption through scratched and abraded skin was 57% over the same time period (Ilyin et al. (cdc.gov)
These types of interactions would be expected for all routes of exposure. (cdc.gov)
Ionizing radiation injures tissues variably, depending on factors such as radiation dose, rate of exposure, type of radiation, and part of the body exposed. (msdmanuals.com)

The PX domain of Vam7p selectively binds PtdIns-3-P, while the PX domain of the CPK PI-3 kinase selectively binds PtdIns-4,5-P(2). (embl.de)
CCL2 acts predominantly via the CC-receptor CCR2, although it also binds to CCR4 (138), whereas CXCL1 and CXCL2 both act via CXCR2 (125). (pancreapedia.org)

Using immunocytochemistry and ELISA, we investigated the production of interleukin (IL)-1β in the rat hippocampus after focal application of kainic acid inducing electroencephalographic (EEG) seizures and CA3 neuronal cell loss. (jneurosci.org)
Representative standard curve for IL-2 ELISA. (abscitech.com)
Dans la présente étude, les taux de production des interleukines 12 et 13 (IL-12 et IL-13) ont été mesurés à l'aide de la méthode ELISA dans les surnageants de culture de cellules mononucléées de sang périphérique stimulées par des mitogènes chez 30 cas de bêta-thalassémie non splénectomisés présentant une surcharge martiale ainsi que chez 20 individus en bonne santé appariés pour l'âge et le sexe. (who.int)

Similarly, inhibition of the PI3K-mTOR pathway by addition of the PI3K inhibitor 2-[4-morpholinyl]-8-phenyl-4H-1-benzopyran-4-one (LY294002) or the mTOR inhibitor rapamycin, although reducing several parameters of transformation, also failed to block transformation. (embl.de)

Here, we focus on newly uncovered pathways, involving either the cyclooxygenases (COXs) or nonenzymatic chemical transformations, that lead to the formation of bioactive prostanoids and of previously unknown lipid mediators produced by COX-2. (jci.org)

2. Tissue injury and inflammatory cell recruitment. (pancreapedia.org)

The sequence of human IL-2 cDNA predicts a 153 amino acid (aa) residue precursor glycoprotein containing a 20 aa residue signal peptide that is cleaved to form the mature protein (3). (abscitech.com)
events have receptors stimulated with students( GAGs), unregulated chains docking of a inactive actin, all of an been protein respiration cell a considerable subunits. (evakoch.com)
1 The BCR-ABL1 fusion protein is a constitutively active tyrosine kinase and triggers a cascade of aberrant downstream signaling pathways leading to clonal outgrowth of CML cells and subsequent disease manifestation. (haematologica.org)

At the amino acid sequence level, mouse IL-2 is approximately 60% identical to human IL-2 (1, 2, 4, 5). (abscitech.com)
The apelin gene located at chromosome Xq25-26.1, encodes a 77 amino acid preproprotein [ 1 ] [ 2 ] . (encyclopedia.pub)

IL-2 has been found to stimulate growth and differentiation of B cells, NK cells, LAK cells, monocytes, and oligodendocytes. (abscitech.com)

In contrast, TNF-α at low concentrations can synergistically and directly enhance the clonal growth of primitive and more mature human CD34+ bone marrow progenitors when combined with GM-CSF or interleukin (IL)-3. (ox.ac.uk)
Case 1: Bone-window CT reveals calcification of the meningioma. (medscape.com)
Taking DHEA by mouth daily for up to 2 years doesn't seem to improve body shape, bone strength, muscle strength, or quality of life in people older than 60 who have low DHEA levels. (medlineplus.gov)

The subsequent development of TNF-α mutants with selective activity on either TNFR55 or TNFR75 suggest that such mutants might maintain the therapeutic (anti-tumor) potential of wild type TNF-α, but exhibit reduced toxicity (proinflammatory effects). (ox.ac.uk)

constitutive but well install Hh being not regulates on the synthesis of development effects through the Toll-like activity. (evakoch.com)
Synthesis of new cyclitol compounds that influence the activity of phosphatidylinositol 4-kinase isoform, PI4K230. (embl.de)

In addition, IL-2 has also been shown to mediate multiple immune responses on a variety of cell types. (abscitech.com)

Clin Radiol 1996;51 Suppl 1:19-23. (2medicalcare.com)

Human IL-2 (also known as T-cell growth factor) is produced by T-cells in response to antigenic or mitogenic stimulation. (abscitech.com)
IL-2 is involved in treatment of cancers such as melanoma and renal cell cancer. (abscitech.com)
The number of cell types expressing IL-6 R does not reflect the spectrum of cell types that can respond to IL-6. (sbhsciences.com)
The gene is located on chromosome 12q23 [ 26 ] and regulates transforming growth factor (TGF)-beta 1 activity as well as the cell cycle [ 27 ] . (encyclopedia.pub)

isoform 1) or by alternative splicing (DS-sIL-6R). (sbhsciences.com)

in exosomes purified from Trop-2-positive PCa cells. (123dok.org)
Trop-2 may be propagated to recipient cells. (123dok.org)
HN - 2008 BX - Granulosa Cells, Cumulus MH - Coronary Sinus UI - D054326 MN - A07.231.908.194.500 MS - A short vein that collects about two thirds of the venous blood from the MYOCARDIUM and drains into the RIGHT ATRIUM. (bvsalud.org)
[ 6 ] T cells and interleukin (IL)‒17 are protective. (medscape.com)

Inhibition of experimental autoimmune encephalomyelitis by an antibody to the intercellular adhesion molecule ICAM-1. (2medicalcare.com)

The gene for IL-2 has been mapped to human chromosome 4q (6). (abscitech.com)
Since their discovery in the mid 1930s as potent bioactive compounds in human semen ( 1 ), prostaglandins and their relatives have fascinated several generations of scientists. (jci.org)
BACKGROUND: We describe changes in rates of cervical intraepithelial neoplasia grades 2, 3 and adenocarcinoma in situ (CIN2+) during a period of human papillomavirus (HPV) vaccine uptake and changing cervical cancer screening recommendations. (cdc.gov)

Strontium is a naturally occurring element that exists in the environment mainly as the free metal or in the (II) oxidation state. (cdc.gov)

Hashimoto's thyroiditis (HT), also known as lymphocytic thyroiditis, is a common autoimmune endocrine disease with an increasing prevalence in recent decades [ 1 , 2 ]. (medsci.org)

As summarized elsewhere (1), the combination of a declining birth rate and an increased average life span is expected to increase the proportion of the population aged 65 years and older in the United States from 12.4% in 2000 to 19.6% in 2030. (cdc.gov)
Globally, the number of older adults (aged 65 years and older) is projected to increase even more dramatically - more than doubling from 420 million in 2000 to 973 million in 2030 (1). (cdc.gov)

Roles of HTLV-1 basic Zip Factor (HBZ) in Viral Chronicity and Leukemic Transformation. (mdpi.com)

[ 1 ] and/or invading the overlying soft tissues, or inducing vascular injuries to the brain. (medscape.com)

This review comprises of the probiotic characteristics, antagonistic activity of probiotic yeasts against PTZ-343 pathogenic fungi and bacteria, plant growth promoting characteristics of candida and biotherapeutic potentials of probiotic yeasts. (enmd-2076.com)
2.?as probiotic is a probiotic candida habitually utilized for the treatment of gastrointestinal tract disorders [9]. (enmd-2076.com)
[ 2 ] Candida is an opportunistic infection and typically occurs where the local ecology is disturbed, or where there is an immune defect. (medscape.com)

The dura is opened, and the meningioma can be seen extending en plaque over the surface of the brain. (medscape.com)

Part Two provides ten important things that you can do to increase and strengthen all of these components. (squareonepublishers.com)
details] Increase in nitric oxide and cyclic GMP of rat cerebellum by radio frequency burst-type electromagnetic field radiation [med. (emf-portal.org)
genetic and environmental factors seem to increase the susceptibility of some individuals in developing this severe inflammatory disease (1) ( Fig. 1 ). (bvsalud.org)

Case 1: Surgical view of the tumor. (medscape.com)

When clinically manifested, gastric the presence or absence of any gross predominance [2]. (who.int)
The presence or absence of a glutamate-leucine-arginine sequence further divides chemokines into 'ELR' and 'non-ELR' chemokines, with ELR-chemokines exhibiting highest activity in chemotaxis assays (65, 130). (pancreapedia.org)

Anatomy49

Organisms10

Diseases9

Chemicals and Drugs130

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Phenomena and Processes36

Disciplines and Occupations1

Information Science3

Health Care2

Cytokine16

Soluble1

Chemokine2

Distinct3

Exerts its biological2

Inflammation5

Signaling pathway1

Vitro2

Pancreatic1

Molecular6

Lymphocytes2

Antagonist3

Expression3

Cytokines8

Induces2

Lymphocyte2

Innate and adaptive2

Systemic1

Peripheral2

Transient1

Chronic4

Involvement1

Bind1

Transmembrane glycoprotein1

Neurons1

20182

Ligand1

Complexes1

Specific9

Biological1

Exposure4

Binds2

ELISA3

Similarly1

Mediators1

Tissue1

Protein3

Amino acid2

Monocytes1

Bone3

Selective1

Synthesis2

Immune responses1

19961

Cell4

Isoform1

Cells4

Intercellular1

Human3

Oxidation1

Endocrine1

20002

Factor1

Tissues1

Candida3

Surface1

Increase3

Tumor1

Presence or absence2