• Abnormalities
  • Aplasia cutis congenita type VI, also known as Bart syndrome, is a rare genetic mechanobullous disorder characterized by congenital localized absence of skin, mucocutaneous blistering lesions, and nail abnormalities. (pubfacts.com)
  • symptoms
  • Relying on recent research findings of the international literature, we intend to help general practitioners or dermatologists treating epidermolysis bullosa patients on a daily basis by identifying symptoms that require consulting an oral professional on the one hand, and to present the most important prevention strategies and further treatments advised for dentists on the other. (pubfacts.com)
  • Patients
  • citation needed]Collagen VII is also associated with the epithelium of the esophageal lining, and DEB patients may suffer from chronic scarring, webbing, and obstruction of the esophagus. (wikipedia.org)
  • Patients should also be at least 7 years of age. (clinicaltrials.gov)
  • Collagen has been widely used in cosmetic surgery, as a healing aid for burn patients for reconstruction of bone and a wide variety of dental, orthopedic, and surgical purposes. (wikipedia.org)
  • After receiving GCSF, patients will be followed at 7 and 30 days following the discontinuation of the drug. (clinicaltrials.gov)
  • A telephone follow-up will be conducted on all patients 28 days after G-CSF so as to evaluate if the effect noted on day 7 was sustained. (clinicaltrials.gov)
  • The investigators have recently observed on patients having residual expression of collagen VII that phenotype severity is modulated by activation degree of dermic metalloproteinase. (clinicaltrials.gov)
  • [7] Antibiotics such as tetracycline or erythromycin may also control the disease, particularly in patients who cannot use corticosteroids. (wikipedia.org)
  • The aim of this comprehensive article is to provide guidelines for the daily treatment of patients with epidermolysis bullosa, thus contributing to the attainment of their higher quality of life through the improvement of their oral health. (pubfacts.com)
  • fibroblast
  • The fibroblast is the most common cell that creates collagen. (wikipedia.org)
  • The next three layers comprise lamina of lipopolysaccharides (LPs), which are stratified by their histological composition of elastin and collagen fibers, with fibroblast, myofibroblast and macrophages interspersed sparsely. (wikipedia.org)
  • severe
  • This form of the condition is somewhat less severe than the classic type and includes a range of subtypes. (nih.gov)
  • basal
  • Anchoring fibrils (composed largely of type VII collagen) extend from the basal lamina of epithelial cells and attach to the lamina reticularis (also known as the reticular lamina) by wrapping around the reticular fiber (collagen III) bundles. (wikipedia.org)
  • skin
  • Immunohistochemical staining of Collagen VII in human skin tissue sections with ab93350. (abcam.cn)
  • Epidermolysis bullosa (EB) is a group of inherited skin disorders characterized by blistering following mechanical trauma. (hindawi.com)
  • Collagen also has many medical uses in treating complications of the bones and skin. (wikipedia.org)
  • [7] This refers to the compound's early use in the process of boiling the skin and tendons of horses and other animals to obtain glue. (wikipedia.org)
  • Both human and bovine collagen is widely used as dermal fillers for treatment of wrinkles and skin aging. (wikipedia.org)
  • Epidermolysis bullosa is a group of genetic conditions that cause the skin to be very fragile and to blister easily. (nih.gov)
  • Type VII collagen plays an important role in strengthening and stabilizing the skin . (nih.gov)
  • Subjects may be of either sex and of any race or skin type provided that their skin color, in the opinion of the Investigator, will not interfere with the study assessments. (clinicaltrials.gov)
  • Variations
  • Additionally, genetic factors cause variations between members of the same sex, with males' and females' voices being categorized into voice types. (wikipedia.org)
  • consists
  • The intermediate layer of LPs consists primarily of elastic fiber while the deep layer LP consists of fewer elastin and more collagen fibers. (wikipedia.org)