• tendon
  • The invention provides graft, prothesis, orthopaedic structures, implants and like body replacement parts which are constituted of synthetic collagen fibers, an embodiment of which is a tendon or a ligament prosthesis, graft or implants. (google.es)
  • 1. A biocompatible, biodegradable graft which is a tendon of improved mechanical properties which comprises aligned cross-linked synthetic collagen fibers embedded in a non-crosslinked and loose collagen matrix, said fibers having a diameter in the range of 20 to about 60 microns. (google.es)
  • 18. The biocompatible, biodegradable graft of claim 10 which has an UTS which is in excess of an autograph or of naturally occurring tendon fibers of rats. (google.es)
  • proteoglycans
  • Cartilage matrix is a homogeneous material principally composed of proteoglycans , macromolecules with a proteinaceous backbone, to which is attached complex carbohydrates (these carbohydrates are "glycosaminoglycans," usually abbreviated GAG s). (diff.org)
  • The major matrix components are collagens and proteoglycans ( 19 ), with collagen type II representing ∼95% of the collagens ( 11 ) and aggrecan ∼95% of the proteoglycans ( 16 ). (rupress.org)
  • Other members of this diverse family include the small cartilage proteoglycans biglycan ( 12 ), decorin ( 28 ), fibromodulin ( 36 ), lumican ( 2 ), and keratocan ( 6 ), as well as PRELP ( 1 ). (rupress.org)
  • The ECM is composed of large proteoglycans (PGs) that contain glycosaminoglycan (GAG), hyaluronic acid (HA), fibers, and other molecular components about fibronectin and laminin. (hindawi.com)
  • Ground substance - A clear, colorless, and viscous fluid containing glycosaminoglycans and proteoglycans to fix the body water and the collagen fibers in the intercellular spaces. (wikipedia.org)
  • molecule
  • In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. (wikipedia.org)
  • Three pro-alpha1(II) chains twist together to form a triple-stranded, ropelike procollagen molecule. (wikipedia.org)
  • In this review, we emphasize the signaling molecule effect and the biomechanics effect of cartilage ECM on chondrogenesis. (hindawi.com)
  • Collagen is used in bone grafting as it has a triple helical structure, making it a very strong molecule. (wikipedia.org)
  • The pro-alpha2(XI) chain combines with pro-alpha1(XI) and pro-alpha1(II)collagen chains to form a procollagen molecule. (wikipedia.org)
  • This chain combines with another pro-alpha1(I) chain and also with a pro-alpha2(I) chain (produced by the COL1A2 gene) to make a molecule of type I procollagen. (wikipedia.org)
  • All of these changes interfere with the formation of the mature triple-stranded collagen molecule and prevent the production of mature type I collagen, which results in type IV osteogenesis imperfecta. (wikipedia.org)
  • fibres
  • 13. The biocompatible, biodegradable graft of claim 8 which has a wet ultimate strain in the range of about 16.10 2.70, 13.0 2.90 and 14.50 3.50 at strain rates of 10, 50 and 100 percent, respectively, wherein the fibres were 2 days cross-linked fibers. (google.es)
  • Natural Fibers or Natural Fibres (see spelling differences) are fibers that are produced by plants, animals, and geological processes. (wikipedia.org)
  • Presence of collagen fibres makes such structures and joints strong but less elastic and movable only to a minor extent. (wikipedia.org)
  • normal collagen
  • Collagen-related diseases most commonly arise from genetic defects or nutritional deficiencies that affect the biosynthesis, assembly, postranslational modification, secretion, or other processes involved in normal collagen production. (wordpress.com)
  • Some mutations affect the production of the pro-alpha2(XI) chain and disrupt normal collagen assembly. (wikipedia.org)
  • cells
  • In an animal model the nanofiber gel with growth factor injected into the injured joint stimulates stem cells to produce the desired type II collagen. (futurepundit.com)
  • This extracellular matrix, which mimics what cells usually see, binds by molecular design one of the most important growth factors for the repair and regeneration of cartilage. (futurepundit.com)
  • By keeping the growth factor concentrated and localized, the cartilage cells have the opportunity to regenerate. (futurepundit.com)
  • General inactivation or activation of these gene doesn't turn all affected cells into one type or another. (wikipedia.org)
  • Since α2β1 also is a receptor for collagen type II, we tested the ability of different antibodies against the α2 subunit to inhibit adhesion of T47D cells to collagen type II and chondroadherin. (rupress.org)
  • Although α2β1 is a receptor for both collagen type II and chondroadherin, only adhesion of cells to collagen type II was found to mediate spreading. (rupress.org)
  • Collagen can be used in collagen dressings, to attract new skin cells to wound sites. (medicalnewstoday.com)
  • They can exist for minutes or years with an average lifespan of 1-2 days in mammalian cells. (wikipedia.org)
  • The interterritorial space between the isogenous cell groups contains relatively more collagen fibers, causing it to maintain its shape while the actual cells shrink, creating the lacunae. (wikipedia.org)
  • Each lacuna is generally occupied by a single cell, but during the division of the cells it may contain two, four, or eight cells. (wikipedia.org)
  • Because only one copy of the gene is directing the cell to make pro-alpha1(I) chains, cells from people with this disorder make only half of the normal amount of type I collagen, which results in bone fragility and other symptoms. (wikipedia.org)
  • The periosteal cells proximal to (on the near side of) the fracture gap develop into chondroblasts, which form hyaline cartilage. (wikipedia.org)
  • triple-stranded
  • The substitution of another amino acid for glycine in this chain inhibits the formation of stable, triple-stranded, ropelike collagen molecules. (wikipedia.org)
  • Type I collagen production is inhibited by the inability of the altered procollagen strands to associate and form the triple-stranded, ropelike structure of mature collagen. (wikipedia.org)
  • differentiation
  • Differentiation of chondroblasts is favored in an environment with high compressive force and low partial oxygen pressure which combine to inhibit protein 3, a protein which inhibits cartilage differentiation. (wikipedia.org)
  • however, cell adhesion, cell-to-cell communication, and differentiation are common functions of the ECM [ 2 ]. (hindawi.com)
  • structures
  • This type provides the perfect balance of structure and flexibility and helps keep tubular structures open. (wisegeek.org)
  • These different types have different structures and functions. (medicalnewstoday.com)
  • The two different structures of keratin have dissimilar mechanical properties, as seen in their dissimilar applications. (wikipedia.org)
  • perichondrium
  • They are located on the perichondrium because the perichondrium, located on the outside of developing bone, is not as heavily ensheathed in cartilage extracellular matrix as the interior and because here where capillaries are located. (wikipedia.org)
  • Appositional growth takes place "at the edge" of the cartilage mass (i.e., between the cartilage proper and the surrounding perichondrium), and interstitial growth occurs "in the middle" of the mass of cartilage. (diff.org)
  • This membrane, perichondrium or synovium, contains vessels that provide the cartilage with nutrition through diffusion. (wikipedia.org)
  • structural
  • OA is defined as a disease resulting in structural and functional failure of synovial joints, which usually is characterized by progressive articular cartilage damage, involvement of the synovium and subchondral bone hypertrophy. (intechopen.com)
  • occurs
  • This process of growth and reshaping occurs in two ways: interstitial growth and appositional growth. (diff.org)
  • Collagen occurs in many places throughout the body. (wordpress.com)
  • Gradual calcium deposition within collagen occurs as a natural function of aging. (wikipedia.org)
  • The most common form of arthritis, osteoarthritis (also known as degenerative joint disease), occurs following trauma to the joint, following an infection of the joint or simply as a result of aging and the deterioration of articular cartilage. (wikipedia.org)
  • This type of injury occurs often in contact sports such as football, rugby, or motocross. (wikipedia.org)
  • intervertebral
  • The use of dual tapered threaded fusion cages and recombinant human bone morphogenetic protein-2 on an absorbable collagen sponge obtained and maintained intervertebral spinal fusion, improved clinical outcomes, and reduced pain after anterior lumbar interbody arthrodesis in patients with degenerative lumbar disc disease. (wikipedia.org)
  • certified organic
  • Experience the digestive power of organic superfoods and live probiotics with Garden of Life RAW Organic Fiber - a certified organic, RAW, vegan daily fiber formula with ingredients specifically selected for their exceptional ability to support digestive health and function. (win-edge.com)
  • synovial joints
  • Synovial joints can in turn be classified into six groups according to the type of movement they allow: plane joint, ball and socket joint, hinge joint, pivot joint, condyloid joint and saddle joint. (wikipedia.org)
  • matrix
  • Once they embed themselves into the cartilage matrix, they grow the cartilage matrix by growing more cartilage extracellular matrix rather than by dividing further. (wikipedia.org)
  • The purified mass is dried to provide the desired Type I collagen product which may be ground into a powder or formed into a collagen matrix or sponge, depending on the end use therefor. (google.co.uk)
  • As you might expect with this much carbohydrate present, the matrix of cartilage is very strongly positive when stained with the PAS reaction for carbohydrates, but in an H&E stained preparation it's sort of a pale pink to blue color. (diff.org)
  • The matrix fills the spaces in the meshwork of Type II fibers. (diff.org)
  • T he cartilage extracellular matrix is highly specialized in its composition and organization to adapt to and withstand mechanical forces. (rupress.org)
  • Articular cartilage ECM plays a crucial role in regulating chondrocyte metabolism and functions, such as organized cytoskeleton through integrin-mediated signaling via cell-matrix interaction. (hindawi.com)
  • joints
  • Arthritis is characterized by the degradation of cartilage in the joints, leading to limited movement and pain. (wisegeek.org)
  • Joints can also be classified functionally according to the type and degree of movement they allow: Joint movements are described with reference to the basic anatomical planes. (wikipedia.org)
  • Another classification is according to the degrees of freedom allowed, and distinguished between joints with one, two or three degrees of freedom. (wikipedia.org)