• Individuals with Myelomeningocele are born with an incompletely fused spine, and therefore exposing the spinal cord through an opening in the back. (wikipedia.org)
  • The focal orthopedic complications of neurofibromatosis, which usually appear early, include spinal deformities such as scoliosis and kyphoscoliosis, congenital bowing and pseudoarthrosis of the tibia and the forearm, chest-wall deformities, overgrowth phenomenon of the extremity, and soft-tissue tumors. (medscape.com)
  • It is most commonly a disease of adulthood that consists of multiple deep painful peripheral nerve sheath tumors, which may occur in a generalized form or in a segmental distribution. (medscape.com)
  • Some other spinal diseases include spinal muscular atrophy, ankylosing spondylitis, lumbar spinal stenosis, spina bifida, spinal tumors, osteoporosis and cauda equina syndrome. (wikipedia.org)
  • Primary spinal tumors begin in either the spinal cord or spinal column, whereas secondary spinal tumors begin elsewhere and spread to the spinal region. (wikipedia.org)
  • Symptoms for spinal tumors may vary due to factors such as the type of tumor, the region of the spine, and the health of the patient. (wikipedia.org)
  • Other reasons for spinal cord - related pain include complications of surgery, tumors, congenital disorders (conditions present at birth), blood vessel - related injury (such as after a spinal cord infarction or stroke), and inflammatory conditions involving the spinal cord. (encyclopedia.com)
  • can reveal vertebral (spinal column) problems, tumors, fractures or degenerative changes in the spine. (mainehealth.org)
  • Meningiomas account for approximately 25% of all spinal tumors. (medscape.com)
  • Most intradural spinal tumors are benign and potentially resectable. (medscape.com)
  • In a recent clinical trial, a gene therapy to treat cerebral adrenoleukodystrophy (CALD) -- a neurodegenerative disease that typically claims young boys' lives within 10 years of diagnosis -- effectively stabilized the disease's progression in 88 percent of patients, researchers from the Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Massachusetts General Hospital report today. (news-medical.net)
  • Viking Therapeutics, Inc., a clinical-stage biopharmaceutical company focused on the development of novel, first-in-class or best-in-class therapies for metabolic and endocrine disorders, today announced that it has submitted an investigational new drug (IND) application to the U.S. Food and Drug Administration to conduct a Phase 2 study of VK2809 in patients with hypercholesterolemia and fatty liver disease. (news-medical.net)
  • Arizona will increase the laboratory capacity to screen for two lysosomal storage disorders, Pompe Disease and Mucopolysaccharidosis Type-1 (MPS-1). (cdc.gov)
  • Most importantly, Soto and his colleagues were able to distinguish between patients with Alzheimer's disease and those with other neurodegenerative or neurological disorders with 90% sensitivity and 92% specificity by applying their test to cerebrospinal fluid samples. (sciencedaily.com)
  • The Alzheimer's Research Center is a national organization that relies on charitable gifts to conduct nationally recognized research for Alzheimer's disease , Parkinson's disease, stroke and other nervous system disorders. (medicalnewstoday.com)
  • From diagnosing back pain to treating sports-related spinal injuries, MaineHealth experts treat a full range of spinal disorders. (mainehealth.org)
  • Maine Medical Center (MMC) is the state's largest and most complete resource for diagnosing and treating spinal disorders. (mainehealth.org)
  • Acute transverse myelitis can accompany demyelinating diseases, such as acme multiple sclerosis, and inflammatory and necrotizing disorders of the spinal cord such as hematomyelia. (family-health-information.com)
  • Freezing of gait (FoG) in Parkinson's disease (PD) is an incapacitating transient phenomenon, followed by continuous postural disorders. (elifesciences.org)
  • This can be caused by stroke, Parkinson's disease, bladder infection, and disorders that affect the spinal cord. (healthinaging.org)
  • Charcot-Marie-Tooth disease can be associated with several disorders that may be encountered by the pulmonary physician, including restrictive pulmonary impairment, sleep apnea, restless legs, and vocal cord dysfunction. (springer.com)
  • 1996) [Respiratory disorders in type-1 hereditary motor and sensory neuropathy]. (springer.com)
  • Study after study has shown that even in the best of centers, we're wrong 1 out of 4 times," says Stuart Isaacson, MD, the director of the Parkinson's Disease and Movement Disorders Center of Boca Raton, Florida. (medscape.com)
  • Without treatment, symptoms of SMA1 become apparent before 6 months of age and include worsening muscle weakness and poor muscle tone (hypotonia) due to loss of the lower motor neurons in the spinal cord and brain stem. (rarediseases.org)
  • Trauma to the spinal cord typically leads to a combination of symptoms and signs resulting from immediate and delayed injury. (medscape.com)
  • Loss of these cells causes many of the signs and symptoms of X-linked infantile spinal muscular atrophy. (medlineplus.gov)
  • Those are symptoms of cervical stenosis disease. (wikipedia.org)
  • citation needed] Only a few symptoms occur for one with this disease, which include feeling tired in the spinal region or backaches. (wikipedia.org)
  • Lumbar spinal stenosis is very prevalent with 9.3% of the general population producing symptoms and the number is continuing to rise in patients older than 60. (wikipedia.org)
  • They will also continue to explore its utility for detecting the disease before symptoms appear. (sciencedaily.com)
  • These include your pet's overall health, the gravity of symptoms displayed, and the specific location and type of disc herniation. (petinsuranceaustralia.com.au)
  • Since this is a progressive disease, symptoms typically worsen over time. (healthline.com)
  • Since osteoarthritis of the spine has symptoms that are similar to other conditions, your doctor may also take your blood to rule out other diseases. (healthline.com)
  • MS and its associated bladder symptoms have a considerable negative impact on patients' quality of life and, although progression of the neurological disease is proving difficult to halt, much can now be done to improve bladder control. (medscape.com)
  • The bladder symptoms in multiple sclerosis become increasingly difficult to manage with progression of spinal cord disease. (medscape.com)
  • Each type of pathology causes significant symptoms, by different mechanisms. (ucl.ac.uk)
  • Our research aims to understand the mechanisms responsible for the disease, in order to arrest them and thereby avoid the production of symptoms even before they have started. (ucl.ac.uk)
  • Developing improved diagnostic techniques relies on biobanks of samples collected from patients with Lyme disease and clinical mimics (i.e., patients with similar signs and symptoms caused by non-Lyme ill- nesses). (cdc.gov)
  • What are the types of spinal muscular atrophy (SMA) and what are their symptoms? (medlineplus.gov)
  • Symptoms of a spinal cord problem can vary and depend on where the spinal cord is damaged. (mainehealth.org)
  • Symptoms of spinal cord injuries depend on the seriousness of the injury and the area of the spinal cord affected. (mainehealth.org)
  • Type III (SMA3) or Kugelberg-Welander disease causes symptoms after the age of 18 months, and these patients acquire autonomous ambulation. (dovepress.com)
  • If you are ill from any disease or notice medical symptoms, you should consult your doctor. (family-health-information.com)
  • As a result of dependence upon higher brain centers, certain lesions or diseases of the brain (eg, stroke, cancer, dementia) can result in a loss of voluntary control of the normal micturition reflex as well as symptoms such as urinary urgency. (medscape.com)
  • Some of the common cervical spine diseases include degenerative disc disease, cervical stenosis, and cervical disc herniation. (wikipedia.org)
  • Degenerative disc disease occurs over time when the discs within each vertebra in the neck begin to fall apart and begin to disintegrate. (wikipedia.org)
  • Osteoarthritis (OA) is a degenerative joint disease affecting an estimated 27 million Americans. (healthline.com)
  • Spinal deformity affects individuals in every age and demographic group, but the prevalence increases with age as many causes are affected by degenerative conditions. (boneandjointburden.org)
  • Adult spinal deformity is a broad diagnostic classification that includes idiopathic scoliosis as well as de novo or degenerative curves, which often result in coronal and/or sagittal plane decompensation. (boneandjointburden.org)
  • The type of lower back problems that can be linked to this condition includes spinal stenosis, degenerative disc disease, lumbar herniated disc, and spondylolisthesis. (toffsworld.com)
  • For those with medical conditions, the problem can stem from Degenerative disc disease, lumbar spinal stenosis, and Spondylolisthesis . (toffsworld.com)
  • SMA is the most common degenerative disease of the nervous system in children. (medscape.com)
  • Scoliosis is a common spinal disease in which the spine has a curvature usually in the shape of the letter "C" or "S". This is most common in girls, but there is no specific cause for scoliosis. (wikipedia.org)
  • Spinal muscular atrophy type II (SMA2), also called "intermediate" SMA, occurs slightly later than type I, between the ages of 6 and 18 months, and is characterized by the absence of acquisition of autonomous ambulation. (dovepress.com)
  • Parkinson's disease), Soto says an FDA-approved test could be on the market in as little as three years. (sciencedaily.com)
  • Stem cells, delivered intranasally, were found to substantially improve motor function in Parkinson's disease in a study co-authored by William H. Frey II, Ph.D, Director of the Alzheimer's Research Center, part of HealthPartners Research Foundation. (medicalnewstoday.com)
  • Researchers say a new spinal implant procedure is helping a man with Parkinson's disease walk properly again. (medicalnewstoday.com)
  • Approximately 20% of patients clinically diagnosed with Parkinson's disease (PD) turn out not to have the movement disorder, resulting in unnecessary treatments, medications, and procedures. (medscape.com)
  • IVDD develops when the discs between the vertebrae undergo degeneration or herniate, leading to the compression of the spinal cord or nerves," Nadia Crighton from Pet Insurance Australia says. (petinsuranceaustralia.com.au)
  • A spinal cord injury involves damage to any part of the spinal cord or nerves at the end of the spinal canal. (mainehealth.org)
  • Motor neuron diseases may involve the central nervous system (brain and spinal cord) as well as the peripheral nervous system (nerves outside the brain and spinal cord). (msdmanuals.com)
  • Nerve cells in the motor cortex connect with the nerve cells in the spinal cord that stimulate muscles to move (called motor nerves). (msdmanuals.com)
  • In motor neuron diseases, these nerve cells progressively wither away and the peripheral nerves that connect them to the muscle deteriorate. (msdmanuals.com)
  • For specific nontraumatic neurologic diseases that affect the spinal cord, see Multiple Sclerosis , Amyotrophic Lateral Sclerosis , and other articles listed in Differentials. (medscape.com)
  • Our primary research focus is multiple sclerosis (MS), an inflammatory demyelinating disease of the brain and spinal cord. (ucl.ac.uk)
  • Amyotrophic lateral sclerosis is a condition that ruins the brain and the spinal cord as well. (rickmer-rickmers.info)
  • Examples include Alzheimer's disease, amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease), osteoporosis and osteoarthritis. (mayo.edu)
  • Review: neuromuscular synaptic vulnerability in motor neurone disease: amyotrophic lateral sclerosis and spinal muscular atrophy. (ox.ac.uk)
  • In this review we discuss experimental data from human patients, animal models and in vitro systems showing that neuromuscular synapses are targeted in different forms of motor neurone disease (MND), including amyotrophic lateral sclerosis and spinal muscular atrophy. (ox.ac.uk)
  • Amyotrophic lateral sclerosis (Lou Gehrig disease) is the most common form of motor neuron disease. (msdmanuals.com)
  • Researchers are making great strides toward developing gene-based strategies to treat a variety of inherited neurometabolic diseases characterized by severe neurological involvement. (news-medical.net)
  • A thorough neurological examination is fundamental to evaluate the spinal cord function and provide the client with a reasonable prognosis. (vin.com)
  • Many patients' bladder problems are now being managed in the same clinic as cares for their underlying neurological disease, although urologic invention might still be necessary to deal with stone formation, recurrent infections and placement of a suprapubic catheter. (medscape.com)
  • MS is typically diagnosed in early adulthood and although the disease course is very variable, it can progress over decades to cause a range of serious neurological deficits, including effects on vision, movement and sensation. (ucl.ac.uk)
  • As the most common spinal disease in dogs, Intervertebral Disc Disease (IVDD) can cause intolerable pain for affected pets and significant costs to pet owners. (petinsuranceaustralia.com.au)
  • and congenital naevoid condition of spinal cord. (ed.ac.uk)
  • For example, only 1 in 10 people who need assistive products has access to 1 Diseases affecting small numbers of patients, including diseases of genetic origin, infrequent forms of cancer, autoimmune diseases, toxic and/or infectious diseases, and congenital deformities. (who.int)
  • The impulse is sent up the spinal cord and through the brain stem to the thalamus, which is a processing center for sensory information, located deep in the brain. (msdmanuals.com)
  • The central nervous system is composed of the brain, brain stem, and the spinal cord. (medscape.com)
  • On the other hand, reactive posture control to external perturbation that mainly relies on neuronal circuitries involving the brainstem and spinal cord, is less influenced by SCS. (elifesciences.org)
  • The signal transmitted by the brain is routed through 2 intermediate segments (the brainstem and the sacral spinal cord) prior to reaching the bladder. (medscape.com)
  • The cord fills the whole spinal canal at the injury level and leads to further secondary ischemia. (medscape.com)
  • When the spinal canal begins to lose its gap and gets thinner, it can cause pain in the neck, which can also cause a numb feeling in the arms and hands. (wikipedia.org)
  • Sagittal reformation nonenhanced CT scan shows a calcified mass in the spinal canal. (medscape.com)
  • Spinal muscular atrophy 1 (SMA1) , also known as Werdnig Hoffmann disease, is a genetic neuromuscular disorder that affects the nerve cells that control voluntary muscles (motor neurons). (rarediseases.org)
  • patients with spinal muscular atrophy presented higher adiposity and lower chest expansion. (bvsalud.org)
  • The medication is injected into the fluid surrounding the spinal cord. (healthline.com)
  • A type of cell derived from amniotic fluid, which is the liquid that surrounds a developing fetus in the amniotic sac. (mayo.edu)
  • We were assisted in that by Tom, because we were infecting horses both peripherally and into the spinal fluid with both strains of virus, both the virulent strains and the avirulent strains, and Carl was overseeing all this. (cdc.gov)
  • Upon examination, the spinal fluid in infants with PeV often has few to no white blood cells. (cdc.gov)
  • Normal gait, spinal pain only. (vin.com)
  • Recent advances in the treatment of spinal muscular atrophy (SMA) have dramatically altered prognosis. (dovepress.com)
  • Considerable differences exist in terms of clinical complications after traumatic and nontraumatic spinal cord injury (SCI). (medscape.com)
  • Following traumatic spinal cord injury (SCI), one of the main concerns from cat-owners is whether their cat can recover (i.e., a "functional pet" that can walk, able to regain urinary/fecal continence). (vin.com)
  • Traumatic animals in shock should be treated prior to assess spinal cord function. (vin.com)
  • Spinal cord - related pain occurs primarily after traumatic injury, usually due to motor vehicle accidents. (encyclopedia.com)
  • A traumatic spinal cord injury happens from a sudden, harsh blow to the spine that fractures, dislocates, crushes or compresses one or more of the vertebrae. (mainehealth.org)
  • In general, the higher the spinal lesion, the greater the functional impairment to the individual. (wikipedia.org)
  • and vascular spinal cord lesion. (ed.ac.uk)
  • 2015-2020 org) at the Johns Hopkins Lyme Disease Research Cen- ter (Baltimore, MD, USA) enrolled 40 adults with an erythema migrans (EM) lesion and followed up with Lise E. Nigrovic, Desire N. Neville, Fran Balamuth, patients for 1 year. (cdc.gov)
  • Spinal angiography usually shows a hypervascular lesion with tumor blush. (medscape.com)
  • Central pain syndrome is a type of pain that occurs because of injuries to the brain or spinal cord . (encyclopedia.com)
  • research suggests a range of 25-85% of all individuals with spinal cord injuries will experience central pain syndrome. (encyclopedia.com)
  • Spinal cord injuries can be complete or incomplete. (mainehealth.org)
  • Spinal cord injuries result from damage to the vertebrae, ligaments or disks of the spinal column or to the spinal cord itself. (mainehealth.org)
  • This read will take a look at the types of injuries that can cause this condition, its response to chiropractic care, and the importance of future rehabilitation. (toffsworld.com)
  • As mentioned, the causes of these injuries can vary based on what the person was doing or what type of accident they got into. (toffsworld.com)
  • This occurred because treatments are being developed that are changing the course of the disease. (rarediseases.org)
  • NORD is not a medical provider or health care facility and thus can neither diagnose any disease or disorder nor endorse or recommend any specific medical treatments. (rarediseases.org)
  • There are many non-surgical treatments available to prevent, halt and even reverse many spine diseases. (wikipedia.org)
  • The findings lend hope that doctors might soon have a way to diagnose the disease while treatments might have a better chance of working -- that is, before extensive brain damage and dementia set in. (sciencedaily.com)
  • With treatments ranging from $200 to an eye-watering $20,000+, pet owners must understand the breeds most at risk and take preventative measures to protect the spinal health of their beloved companion animal. (petinsuranceaustralia.com.au)
  • What are the treatments for spinal muscular atrophy (SMA)? (medlineplus.gov)
  • Phase 2 trials are offered to patients whose disease has not responded to standard types of treatments or to patients whose disease doesn't have a standard treatment. (childrensoncologygroup.org)
  • Two complications to be aware of are issues with breathing and spinal curvature. (healthline.com)
  • Spinal deformity is caused by abnormal curvature of the spine putting it out of alignment. (boneandjointburden.org)
  • Acute transverse myelitis, which affects the entire thickness of the spinal cord, produces both motor and sensory dysfunction. (family-health-information.com)
  • Charcot-Marie Tooth disease (CMT) encompasses several inherited peripheral motor-sensory neuropathies and is one of the most common inherited neuromuscular diseases. (springer.com)
  • 1987) Diaphragmatic dysfunction in siblings with hereditary motor and sensory neuropathy (Charcot-Marie-Tooth disease). (springer.com)
  • The impulse travels along a sensory nerve to the spinal cord. (msdmanuals.com)
  • The impulse crosses a synapse (the junction between two nerve cells) between the sensory nerve and a nerve cell in the spinal cord. (msdmanuals.com)
  • Certain toxic agents (carbon monoxide, lead, and arsenic) can cause a type of myelitis in which acute inflammation (followed by hemorrhage and, possibly,necrosis) destroys the entire circumference (myelin, axis cylinders, and neurons) of the spinal cord. (family-health-information.com)
  • It often follows acute infectious diseases, such as measles and pneumonia (the inflammation occurs after the infection has subsided), and primary infections of the spinal cord itself, such as syphilis and acute disseminated encephalomyelitis. (family-health-information.com)
  • Those diagnosed with type 1 SMA typically have only two SMN2 genes. (healthline.com)
  • People with type 2 SMA typically have three or more SMN2 genes. (healthline.com)
  • People with type 3 SMA typically have four to eight SMN2 genes. (healthline.com)
  • In general, any SCI patient presented with paraplegia/tetraplegia without deep pain perception (DPP), the prognosis for functional recovery is guarded as the "spinal cord function" is completely blocked or transected at the injured site. (vin.com)
  • The prognosis for dogs with IVDD can vary widely, depending on the extent of spinal cord damage and the timeliness and effectiveness of the chosen treatment. (petinsuranceaustralia.com.au)
  • Prognosis for patients with SMA type 2 has shifted from slow and progressive deterioration to long-term stability. (dovepress.com)
  • Children with X-linked infantile spinal muscular atrophy usually do not survive past early childhood due to respiratory failure, although, in rare cases, affected individuals can survive into adolescence. (medlineplus.gov)
  • One such form is spinal muscular atrophy with respiratory distress (SMARD). (healthline.com)
  • Respiratory muscle weakness is generally the cause of death in children with type 1 or 2 SMA. (healthline.com)
  • A cold is the biggest threat to her health now because most children with Type 1 SMA die from respiratory infections. (smasupport.com)
  • A Consensus Conference Report (1999) Clinical indications for noninvasive positive pressure ventilation in chronic respiratory failure due to restrictive lung disease, COPD, and nocturnal hypoventilation. (springer.com)
  • spinal muscular atrophy patients present muscle weakness, orthopedic problems, nutritional complications and respiratory impairment. (bvsalud.org)
  • Scientists from the University of Bonn, the German Center for Neurodegenerative Diseases and the German Cancer Research Center investigated such peroxisomal diseases on fruit flies. (news-medical.net)
  • Spinal muscular atrophy (SMA) is a neurodegenerative disease produced by low levels of Survival Motor Neuron (SMN) protein that affects alpha motoneurons in the spinal cord. (mdpi.com)
  • The development of a simple skin biopsy test could not only enable clinicians to confirm suspicions of PD and other neurodegenerative diseases much earlier but also help pharmaceutical companies create drugs that target pSyn. (medscape.com)
  • Over the years, the polio eradication program in the African Region has developed the technical expertise, disease surveillance and community networks and logistics capacity to respond to other diseases, and is often the first response to disease outbreaks, including the Ebola outbreaks in West Africa (2014) and DRC (2019). (who.int)
  • EPM is a parasitic disease that affects the brain, spinal cord, and nervous system in horses. (petmedoutlet.com)
  • It is a parasite disease that affects the spinal cord, nervous system and brain of a horse. (petmedoutlet.com)
  • Overview of the Peripheral Nervous System The peripheral nervous system refers to the parts of the nervous system that are outside the central nervous system, that is, those outside the brain and spinal cord. (msdmanuals.com)
  • Normal voiding is essentially a spinal reflex modulated by the central nervous system (brain and spinal cord), which coordinates function of the bladder and urethra. (medscape.com)
  • However, sometimes people with physical or cognitive conditions can have the above types of incontinence or abnormal bladder function as well. (healthinaging.org)
  • Previously, the only methods for detecting abnormal protein were autopsy and spinal tap. (medscape.com)
  • X-linked infantile spinal muscular atrophy is a condition that affects only boys and is characterized by severe muscle weakness and absent reflexes (areflexia). (medlineplus.gov)
  • IVDD is a debilitating spinal condition that affects the cushion-like discs between the vertebrae, causing pain, weakness, and mobility issues in affected dogs. (petinsuranceaustralia.com.au)
  • A drug used to control Type II diabetes can help repair the spinal cords of mice suffering from the inherited disease adrenoleukodystrophy which, untreated, leads eventually to a paralysis, a vegetative state and death. (news-medical.net)
  • Build newborn screening laboratory capacity to screen for new Recommended Uniform Screening Panel (RUSP) conditions: Pompe Disease, Mucopolysaccharidosis Type 1 (MPS-1), X-linked Adrenoleukodystrophy (X-ALD), and Spinal Muscular Atrophy (SMA). (cdc.gov)
  • Nevada will implement newborn screening tests for Spinal Muscular Atrophy (SMA) and X-linked Adrenoleukodystrophy (X-ALD). (cdc.gov)
  • It's the most common, and the most severe, type of SMA. (healthline.com)
  • Type 3 SMA is less severe than types 1 and 2. (healthline.com)
  • The second type of child we see is one who has normal anatomy but has developed severe or chronic constipation. (childrensmercy.org)
  • It is the most severe type. (medlineplus.gov)
  • In more severe cases, the signs show up even before or just after birth (Types 0 or 1A). (medlineplus.gov)
  • Type ll is a moderate to severe type of SMA. (medlineplus.gov)
  • Rather than a rapidly lethal disease, SMA type 1, the most severe form with the earliest onset of SMA, has become a disease in which long-term event-free survival with the acquisition of important motor milestones is likely. (dovepress.com)
  • Guillain-Barre Syndrome is a severe disease that affects the polarity of the immune system. (vsebolezni.com)
  • PeV-A3 is most often associated with severe disease. (cdc.gov)
  • The webinar, scheduled on 5 July 2023, from 1600-1700 CEST, is designed for individuals who currently practice in rare bone diseases, or are new to the field, and are interested in gaining clinical skills in the topic. (ectsoc.org)
  • A second major line of research concerns cerebral small vessel disease, which becomes common with ageing, and is a major cause of strokes and dementia. (ucl.ac.uk)
  • This latter condition is common in patients with Alzheimer's and other types of dementia. (healthinaging.org)
  • Some of the less common types of SMA may be caused by changes in other genes. (medlineplus.gov)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) is issuing this Health Alert Network (HAN) Health Advisory to inform clinicians and public health departments that parechovirus (PeV) is currently circulating in the United States. (cdc.gov)
  • Children with type 2 SMA won't be able to stand on their own and will have weakness in the muscles of their arms and legs. (healthline.com)
  • also known as spinal muscular atrophy) is an autosomal recessive hereditary disease characterized by progressive hypotonia and muscular weakness. (medscape.com)
  • The characteristic muscle weakness occurs because of a progressive degeneration of the alpha motor neuron from anterior horn cells in the spinal cord. (medscape.com)
  • Spinal complications are the most common orthopedic manifestation of NF1. (medscape.com)
  • Many children with type 1 SMA will only live a few years due to complications with breathing. (healthline.com)
  • Meningococcal conjugate vaccine (MCV4) - This protects against four types of meningococcal bacteria that causes meningitis, a disease that affects the brain and spinal cord. (webmd.com)
  • 2001) Charcot-Marie-Tooth disease associated with Type 2 diabetes mellitus. (springer.com)