Tumour progression cell proliferation neoplasms plasma cell. Medical search. Frequent questions

The most frequent tumor suppressor miRs were miR-126, miR-199b and miR-22 and the hypoexpression of these miRs was associated with distant metastasis, worse prognosis and a higher risk of disease relapse (worse disease-free survival). (biorxiv.org)
Overexpression of this gene is associated with tumor cell proliferation and metastasis. (cancerindex.org)
DRAM2 was preferentially upregulated in NSCLC tissues and higher expression of DRAM2 in NSCLC correlated with tumor node metastases stage and lymph node metastasis. (cancerindex.org)
Additionally, DRAM2 overexpression promoted cell metastasis and proliferation in vitro, while knockdown of DRAM2 expression yielded opposite result. (cancerindex.org)
ClC-3 may be an important promoter for aggressive metastasis of malignant tumors. (biomedcentral.com)
The expression level of ClC-3 was closely-related to the histological differentiation (p = 0.029), tumour staging ( p = 0.016), tumour size ( p = 0.039), vascular invasion ( p = 0.045), interstitial infiltration depth ( p = 0.012), lymphatic metastasis ( p = 0.036), and HPV infection ( p = 0.022). (biomedcentral.com)
Studies have found that membrane ion channels play a significant part in the progress and metastasis of malignant tumours [ 3 ]. (biomedcentral.com)
Recent studies show that ClC-3 plays an active and vital role in accelerating neoplasm metastasis and may be a prognostic biomarker of tumour dissemination [ 11 ]. (biomedcentral.com)
Angiogenesis is essential in the process of carcinogenesis to facilitate tumor progression and metastasis. (spandidos-publications.com)
Additionally, the expression and activity of matrix metalloproteinases (MMPs) are increased in almost every type of human cancer, which may be associated with cell invasion, metastasis and angiogenesis. (spandidos-publications.com)
MMPs have been implicated in these processes and a previous study has suggested that the plasma level of MMP-2 and MMP-9 may be viewed as a non-invasive indicator of invasiveness and metastasis in colon cancer ( 3 ). (spandidos-publications.com)
NF-kappaB and AP-1 transcriptional factors contribute to the development and progression of prostate malignancy by regulating the expression of genes involved in proliferation, apoptosis, angiogenesis, and metastasis. (positivehealth.com)
The above studies shows how Vitamin E succinate interacts in different ways with the complex array of genes involved in the development and progression of prostate cancer - genes involved in proliferation, apoptosis, angiogenesia and metastasis. (positivehealth.com)
Accumulating evidence indicates that circRNAs in exosomes are associated with solid tumor invasion and metastasis. (biomedcentral.com)
With a latency period averaging 3.6 years from diagnosis of the primary neoplasm (ranging two months to 19 years), the onset of MAR often heralds the presence of nonocular metastasis. (reviewofophthalmology.com)
The tumour was transmural and the lymph nodes were free from metastasis. (scielo.org.za)
Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. (lookformedical.com)
ASPH appears to be involved in the regulation of proliferation, invasion and metastasis of PC cells through multiple signaling pathways, suggesting its role as a tumor biomarker and therapeutic target. (bjbms.org)
DEGs Bcl3, ADGRG7, FABP4, IRF4, their regulating miRNAs and TFs have strong impact on proliferation and metastasis of breast cancer in bone tissues. (degruyter.com)
In conclusion, present study revealed that DEGs are directly involved in of breast tumor metastasis in bone tissues. (degruyter.com)
In addition, previous studies have shown that lysosomes may play important roles in cancer development and progression through the abovementioned biological processes and that the functional status and spatial distribution of lysosomes are closely related to cancer cell proliferation, energy metabolism, invasion and metastasis, immune escape and tumor-associated angiogenesis. (biomedcentral.com)
In melanoma, i have focused in acral lentiginous melanoma for which we described KIT mutation and protein expression status in a large series of cases and described TERT amplification in progression to metastasis. (mdanderson.org)

This may be secondary to a germinal center origin or attributable to increased apoptosis via induction of bax and/or enhanced T-cell interaction, resulting in improved autologous tumor response. (aacrjournals.org)
Our results indicated that AST inhibits cell proliferation through phase-specific cell cycle arrest and caspase-dependent apoptosis. (spandidos-publications.com)
MicroRNA-543 promotes cell invasion and impedes apoptosis in pituitary adenoma via activating the Wnt/β-catenin pathway by negative regulation of Smad7. (cancerindex.org)
HP75 cells treated with overexpressed miR-543 exhibited increased cell proliferation, migration and invasion, while decreased cell apoptosis as well as expression of Cleaved caspase-3 and Cleaved caspase-8 were observed. (cancerindex.org)
Cell counting was performed after trypan blue staining, cell proliferation was assessed using MTT assay, and apoptosis was evaluated through caspase-3 activation and Tunel assay. (biomedcentral.com)
NF-κB and AP-1 are responsible for the coordinated expression of several genes that control inflammation, cell proliferation and apoptosis. (biomedcentral.com)
The MDS cell of origin is a hematopoetic stem cell that proliferates and escapes apoptosis. (standardofcare.com)
These abnormalities result in significant alterations in gene expression related to cell proliferation, apoptosis, migration and immune signaling pathways. (spandidos-publications.com)
Lysosomes are an important component of the inner membrane system and participate in numerous cell biological processes, such as macromolecular degradation, antigen presentation, intracellular pathogen destruction, plasma membrane repair, exosome release, cell adhesion/migration and apoptosis. (biomedcentral.com)

Specific tissue miRs are shown to be promising prognostic biomarkers in patients with CRC, given their strong association with the prognostic aspects of these tumors, however, new studies are necessary to establish the sensibility and specificity of the miRs in order to use them in clinical practice. (biorxiv.org)
In particular, we summarize in detail the mechanism and roles of exosomal circRNAs and highlight their application as novel biomarkers in malignant tumors. (biomedcentral.com)
In view of the wider availability, faster scanning times, and low cost compared with MR perfusion, PCT is potentially well-suited to study brain tumors 6 , 7 and could potentially be useful as an easy tool for quantitative estimates of perfusion parameters and their use as imaging biomarkers. (ajnr.org)
Biomarkers of the transsulfuration pathway and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. (who.int)

A vast amount of research exists on the possible molecular mechanisms through which vitamin D affects cancer cell proliferation, cancer progression, angiogenesis, and inflammation. (mdpi.com)
In the present study, we aimed to further examine the potential of formononetin in controlling angiogenesis and tumor cell invasiveness in human colon cancer cells and tumor xenografts. (spandidos-publications.com)
These findings suggest that formononetin inhibits angiogenesis and tumor cell invasion, and thus support its use in the treatment of advanced and metastatic colon cancers. (spandidos-publications.com)
The vascular endothelial growth factor (VEGF) is a well characterized angiogenic factor known to stimulate angiogenesis within a tumor ( 1 ). (spandidos-publications.com)
Histologic evaluation of tumor angiogenesis by using various markers such as MVD, MVCP, and TVA is also limited by this regional heterogeneity, and its confounding effect is worsened by its small size and a limited number of samples obtained with surgical biopsy. (ajnr.org)
Angiogenesis, the recruitment of new blood vessels from the pre-existing vascular matrix, is now a well-established prerequisite for tumor progression. (cancernetwork.com)
Growth factors such as fibroblast growth factor (FGF), vascular endothelial cell growth factor (VEGF), and angiopoietin-1 (Ang1) are upregulated to stimulate angiogenesis, while downregulation of endogenous protein inhibitors (thrombospondin 1 and interferon) disrupts the balance of physiologic angiogenesis. (cancernetwork.com)
Knockdown of Cripto-1 inhibits the proliferation, migration, invasion, and angiogenesis in prostate carcinoma cells. (cusabio.com)

Although bone marrow fibrosis is seen in a variety of malignant and non-malignant disease states, the deposition of reticulin and collagen fibrosis in the bone marrow of patients with myelofibrosis is believed to be mediated by the myelofibrosis hematopoietic stem/progenitor cell, contributing to an impaired microenvironment favoring malignant over normal hematopoiesis. (haematologica.org)
We discuss the rationale of various anti-fibrogenic treatment strategies targeting the clonal hematopoietic stem/progenitor cell, aberrant signaling pathways, fibrogenic cytokines, and the tumor microenvironment. (haematologica.org)
Over the last decade, significant investigation in the MM field has demonstrated that the interaction of malignant PCs with BM stromal cells within the microenvironment is essential for survival of the PC clone [ 5 , 6 ]. (oncotarget.com)
The observation of this intercellular communication and that MM cells modify the microenvironment is highly suggestive that one of the first biologically relevant changes necessary for progression of MGUS or SMM to MM is for a member(s) of the clone to evolve and acquire the molecular changes needed to reprogram its immediate microenvironment into a supportive, growth-promoting microenvironment. (oncotarget.com)
Our work represents a longitudinal investigation for tumor and microenvironment during MM progression and paves the way for expanding treatment options. (wustl.edu)
They were nanoscale membrane vesicles that were generated by most types of cells, which can convey information in the tumor microenvironment by transferring cargos such as DNA, RNA, proteins and lipids, therefore they are critical to tumor progression [ 5 ]. (biomedcentral.com)
The bone marrow microenvironment and inflammatory signaling can also determine the rate of development and progression of MDS. (standardofcare.com)
Growing evidence suggests that the interaction between the genomic/epigenomic aberrations in cancer cells and the surrounding microenvironment, composed of immune and stromal cells, contributes to the development of tumor invasion via mechanisms such as the so-called "angiogenic switch,"[3-5] creating multiple opportunities for therapeutic intervention. (cancernetwork.com)
The microenvironment is fundamental in attracting tumor cells to the bone as well as promoting tumor progression. (degruyter.com)
The composition of the tumor microenvironment changes during tumor development, evolving to meet the demands of the growing neoplasm [ 6 ]. (degruyter.com)

PFS was defined by the time from ASCT to the disease progression. (bvsalud.org)
The OS was defined as the time from the the start of treatment to the death from disease progression. (bvsalud.org)
During the monitored period we recorded 4 deaths due to disease progression, all of them in the HCRA subgroup. (bvsalud.org)
The median OS in both subgroups was not reached, however the only deaths due to disease progression were recorded in the HRCA subgroup. (bvsalud.org)
Despite recent treatment advances, it is still incurable as disease progression is not fully understood. (wustl.edu)
The aforementioned posterior pole changes seen with disease progression in CAR have also been described in MAR. 10 Visual field testing most commonly reveals generalized constriction. (reviewofophthalmology.com)
For patients with MCL, CLL, or SLL, the recommended dose of CALQUENCE is 100 mg taken orally approximately every 12 hours until disease progression or unacceptable toxicity. (drugs.com)

The T category informs about tumor growth, depth and stage of adjacent tissues invasion. (biorxiv.org)
Previously, our studies found that ClC-3 plays a key role in ectopic endometrial cell migration and invasion [ 5 ]. (biomedcentral.com)

Clonal T-cell receptor gene rearrangements are detected in 75% of cases, and immunoglobin gene rearrangements are seen in 10% of cases, and these cases are believed to be due to expanded EBV-driven B-cell populations. (wikipedia.org)
Plasma cell lesions are the neoplastic (clonal) proliferation of plasma cells involving single bones (plasmacytoma) or multiple bones (multiple myeloma). (medscape.com)
Plasma cell myeloma (multiple myeloma, myelomatosis, medullary plasmacytoma) is a bone marrow-based, malignant disorder of postgerminal center B-cells that is characterized by a clonal proliferation of plasma cells, with associated serum and/or urine monoclonal proteins. (medscape.com)
Asymptomatic plasma cell myeloma is a plasma cell neoplasm defined by the presence of serum monoclonal protein of 3.0 gm/dL or greater (by electrophoresis) and/or clonal plasma cells in the bone marrow of 10% or greater, without evidence of end-organ damage (hypercalcemia, renal insufficiency, anemia, lytic lesions of bone). (medscape.com)
Symptomatic plasma cell myeloma is a plasma cell neoplasm defined as the presence of end-organ damage (hypercalcemia, renal insufficiency, anemia, lytic lesions of bone) in a patient with a monoclonal protein (of any amount) and clonal plasma cells in the bone marrow (of any amount) or plasmacytoma. (medscape.com)
Multiple myeloma (MM) is characterized by the clonal expansion of malignant plasma cells within the bone marrow. (oncotarget.com)
Clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis and peripheral cytopenias. (standardofcare.com)
Criteria for diagnosis of MDS consist of anemia, thrombocytopenia, or neutropenia that persist for six months or longer, dysplasia greater than 10% in at least one bone marrow cell lineage, and MDS associated clonal cytogenetic abnormalities or molecular markers. (standardofcare.com)
There is clonal proliferation of malignant hematopoietic stem cells, dysregulated cellular differentiation, and compromised tissue function. (standardofcare.com)
The mutation occurs in hematopoetic stem cells capable of self renewal and additional mutations are associated with clonal progression may occur in progenitor cells conferring a self renewal capability. (standardofcare.com)
The clonal outgrowth of mutant stem cells favors and abnormal hematopoietic stem cell niche. (standardofcare.com)
The uniformity of the numbers of terminal repeats (TRs) among EBV positive carcinoma cells reflects the clonal origin of a tumor and suggests that EBV is a causative virus for gastric carcinoma ( 6 ). (spandidos-publications.com)
Overview of Myeloproliferative Neoplasms Myeloproliferative neoplasms are clonal proliferations of bone marrow hematopoietic stem cells, which can manifest as an increased number of functionally normal platelets, red blood cells (RBCs). (msdmanuals.com)
Some persons with clonal hematopoiesis are at increased risk for the development of myeloid cancers such as acute myeloid leukemia or myelodysplastic syndromes, a risk that increases as the hematopoietic clone expands in size.16 Stopping this expansion may delay or avert leukemic progression, and therapeutic approaches to this end are being developed and tested. (cdc.gov)

WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. (wikipedia.org)
The tumor size and the number of proliferating cells were reduced in the tumor tissues obtained from the formononetin-treated group. (spandidos-publications.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
As per the WHO classification of tumors of hematopoietic and lymphoid tissues , multiple myeloma is called plasma cell myeloma 14 . (radiopaedia.org)
In obese humans, adipocyte-secreted CCL20 may contribute to the deposition of Compact disc4+ helper and Compact disc8+ cytotoxic T lymphocytes within adipose tissues, possibly via connections with CCR6 which was upregulated on T cells in obese adipose tissues (100). (exposed-skin-care.net)
However, the main element substances that mediate T cell infiltration into adipose tissues in maturing remain to become discovered. (exposed-skin-care.net)
Activation of Typical T Cells in Adipose Tissues Compact disc4+ Purpureaside C T Cell Activation TCRs recognize the current presence of a particular antigen by binding to brief peptide sequences in the antigen that's shown on APCs. (exposed-skin-care.net)
further defined that mostly huge adipocytes from obese adipose tissues exhibited an increased expression degree of MHCII substances and acted as APCs to activate Compact disc4+ T cells to secrete IFN- (103). (exposed-skin-care.net)
genic models are inadequate for number of activated CD8-positive T LMP1 was strongly expressed in the understanding the cancer etiology in cells increased considerably in the lymphoma tissues but was hardly the context of natural viral infection. (who.int)

Plasmacytoma is a neoplastic proliferation of monoclonal plasma cells, which can present clinically as solitary bone neoplasm, extramedullary plasmacytoma, and multiple myeloma. (autopsyandcasereports.org)
The biological behavior of these tumors is variable from periods of clinical latency to rapid growth and progression from localized forms to more disseminated multiple myeloma. (autopsyandcasereports.org)
Multiple myeloma (MM) is an incurable neoplasm caused by proliferation of malignant plasma cells in the bone marrow (BM). (huji.ac.il)
Multiple myeloma (MM) is characterized by the uncontrolled proliferation of plasma cells. (wustl.edu)
Multiple myeloma (MM) , also known as plasma cell myeloma , is a multifocal proliferation of plasma cells based in the bone marrow . (radiopaedia.org)
A rare, aggressive variant of MULTIPLE MYELOMA characterized by the circulation of excessive PLASMA CELLS in the peripheral blood. (lookformedical.com)
Multiple myeloma (MM) is an incurable cancer in which uncontrolled plasma cell proliferation disrupts the bone marrow environment and impairs immune function. (hrb.ie)

While the World Health Organization (2016) has classified these EBV-associated cases as one of the Epstein-Barr virus-associated lymphoproliferative diseases (see EBV+ angioimmunoblastic T cell lymphoma, the role of the virus in the development and progression of EBV+ angioimmunoblastic T cell lymphoma is unclear. (wikipedia.org)
LPA receptors and autotaxin (ATX), a secreted phosphodiesterase that produces this phospholipid, are overexpressed in many cancers and impact several features of the disease, including cancer-related inflammation, development, and progression. (hindawi.com)
CRISPEN and COLLEAGUES, Fox Chase Cancer Center, Philadelphia, PA 19111, USA studied the interaction with and modulation of Vitamin E succinate upon transcriptional factors involved in the development and progression of prostate cancer. (positivehealth.com)
Oxidative stress is involved in development and progression of lung cancer, through cellular and molecular mechanisms which at least in part overlap with proinflammatory pathways. (biomedcentral.com)
Therefore, identifying the factors and mechanisms that regulate the functional status and spatial distribution of lysosomes and elucidating the relationship between lysosomes and the development and progression of cancer can provide important information for cancer diagnosis and prognosis prediction and may yield new therapeutic targets. (biomedcentral.com)

Global CpG island hypermethylation, which induces epigenetic silencing of tumor suppressor genes, is also a unique feature of EBVaGC and is considered to be crucial for its carcinogenesis. (spandidos-publications.com)
Inoculation with a high dose strains of LMP1 transgenic mice vide a powerful tool in mechanistic of EBV caused a B-cell lymphopro- were established that express LMP1 studies on the role of individual viral liferative disorder in these mice, under the control of the immunoglob- genes in cancer. (who.int)
Trial organizers announced that the first participant had been treated using immune cells with four base-edited genes, equipping the cells to better target and destroy tumors. (cdc.gov)

LPA acts as an autocrine/paracrine messenger through at least six G protein-coupled receptors (GPCRs), known as LPA 1-6 , to induce various cellular processes including wound healing, differentiation, proliferation, migration, and survival. (hindawi.com)
However, the tumour cells have undergone hypermutation, 21 23 a feature of the GC reaction during B-cell activation and differentiation. (bmj.com)
Genetic and epigenetic controls of hematopoiesis, Hematopietic stem cell differentiation and lineage specification. (cancertreatmentjournal.com)
Btk is required for the proliferation and differentiation of B lymphocytes. (medscape.com)
However, murine models, including knockout and transgenic mice, have been useful in understanding the mechanisms of B lymphopoiesis, B-cell differentiation, and antibody formation. (medscape.com)
Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)
In this study, highly purified, flow-cytometry sorted, classified in relation to normal B-cell differentiation [1]. (lu.se)

Although this data does not support a role of TRIM13 as a TSG, it substantiates important roles of TRIM13 in MM tumour survival and proliferation, underscoring its potential role as a novel target for therapeutic intervention. (huji.ac.il)
this suggests that ClC-3 may function as a patent tumour biomarker and a latent therapeutic target for cervical carcinoma patients. (biomedcentral.com)
Hematopoietic stem cell transplantation remains the only curative therapeutic approach that reliably results in resolution of bone marrow fibrosis in patients with myelofibrosis. (haematologica.org)
As such, in the current review, we summarize the generation and biological functions of circRNAs and exosomes, analyze the mechanism of exosomal circRNAs in a wide variety of malignant tumors including solid cancers and hematological malignancies, and highlight their promising potential not only as diagnostic molecular markers but also as therapeutic targets. (biomedcentral.com)
Both miRNAs and siRNAs need to be delivered into the target tissue or cell in order to activate the desired therapeutic effect," Muthiah Manoharan, Ph.D., senior vp, drug discovery, Alnylam Pharmaceuticals, explained. (genengnews.com)
Perfusion imaging has been used to assess tumor grade and prognosis and, recently, to assess treatment response, which has attracted more attention due to the advent of newer therapeutic options, including antiangiogenic agents. (ajnr.org)
These differences affect the progression of cancer and how it responds to therapeutic agents and their ultimate efficacy. (degruyter.com)
B-cell lymphomas (BCLs) constitute a diverse set of tially identify new functional, diagnostic, and therapeutic tumors, both morphologically and clinically, that are mainly targets. (lu.se)
Analyzing samples from 805 children with newly diagnosed ALL from three consecutive clinical trials, we determined the ex vivo sensitivity of primary leukemia cells to 18 therapeutic agents across 23 molecular subtypes defined by leukemia genomics. (cdc.gov)

Angioimmunoblastic lymphadenopathy (AILD)-type T-cell lymphoma: prognostic impact of clinical observations and laboratory findings at presentation. (wikipedia.org)
Using the PubMed database, Cochrane Library and Web of Science, studies published in English evaluating miRs differentially expressed in tumor tissue and significantly associated with the prognostic aspects of CRC were selected. (biorxiv.org)
In the subgroup of RT as only local treatment (n = 278), no intracranial tumor extension and complete remission at end of treatment were significant positive prognostic factors. (bvsalud.org)
A number of studies indicate that bone marrow fibrosis is an adverse prognostic variable in myeloproliferative neoplasms. (haematologica.org)

Treatment with alpha-tocopherol succinate (VES) inhibits NF-kappaB but augments AP-1 activity, reduces expression of IL-6, IL-8, and VEGF, suppresses cell adhesion, ICAM-1 and gp130 expression in androgen-independent PC-3, DU-145, and CA-HPV-10 cells. (positivehealth.com)
Vitamin E succinate inhibits NF-kappaB and prevents the development of a metastatic phenotype in prostate cancer cells: implications for chemoprevention. (positivehealth.com)
It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action. (lookformedical.com)

In the last 8 decades, theories regarding carcinogenesis have progressed to include numerous pathways by which cells achieve immortality. (cancernetwork.com)

Burkitt lymphoma (BL) is an aggressive B-cell malignancy with endemic, sporadic and immunodeficiency-associated variants. (bmj.com)
EBV was the first virus to be associated with human malignancy, which was discovered from a Burkitt's lymphoma cell line in 1964 ( 1 ). (spandidos-publications.com)
In vivo perfusion imaging techniques provide additional information regarding tumor physiology and hemodynamics, which may help in better characterizing glioma malignancy and may also overcome some of the limitations of histologic grading and conventional morphologic imaging. (ajnr.org)
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. (lookformedical.com)

Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)
For other human tumour virus- primate species are related to the hu- tween data in humans and in experi- es, the use of humanized severe man tumour viruses, the incidence of mental animals is not obvious. (who.int)
These in vitro, and their expression in these human tumour virus. (who.int)

Remove the appendix if mucinous tumor is present. (medscape.com)

In either form of plasma cell myeloma, immune dysfunction, cytopenias and lytic bone lesions occur as a result of direct cellular interactions (cytokines, growth factors) and/or mass effect. (medscape.com)
while this machinery was originally identified by its ability to allow cells to survive starvation via lysosomal degradation to recycle cellular components, it has recently become apparent that it also is used by cells to secrete cytoplasmic constituents. (liverpool.ac.uk)

It is the most common primary malignant bone neoplasm in adults. (radiopaedia.org)

3 Myelofibrosis (MF) refers to the Philadelphia chromosome ( BCR-ABL1 )-negative myeloproliferative neoplasm (MPN) originating at the level of the multipotent hematopoietic stem cell. (haematologica.org)
Polycythemia vera is a chronic myeloproliferative neoplasm characterized by an increase in morphologically normal red cells (its hallmark), but also white cells and platelets. (msdmanuals.com)

Tumor vascular perfusion parameters obtained by using CT or MR perfusion have been used for tumor grading, prognosis, and treatment response in addition to differentiating treatment/radiation effects and non-neoplastic lesions from neoplasms. (ajnr.org)
High-grade gliomas can be highly invasive and extremely vascular tumors. (ajnr.org)
3 - 5 However, PCT, which has also been used recently for glioma grading, 6 , 7 provides a linear relationship between tissue attenuation and tissue concentration of a contrast agent, unlike perfusion MR imaging, and, hence, probably provides a more robust and less biased estimation of hemodynamic (tumor blood volume) and physiologic (tumor vascular leakiness) parameters. (ajnr.org)
Kaposi sarcoma is a vascular neoplasm composed of endothelium-lined vascular spaces and spindle-shaped cells. (bvsalud.org)
Kaposi's sarcoma is a neoplasm of vascular endothelium that is characterized by proliferation of spindle cells, neoangiogenesis, inflammation and edema 17 . (bvsalud.org)

Within this deleted region the tripartite motif containing 13 (TRIM13, also termed RFP2) gene product has been proposed to be a tumour suppressor gene (TSG). (huji.ac.il)
In search for subgroups of diffuse large B-cell lymphoma (DLBCL) with different histogenetic origin and prognosis, as has been described by gene expression profiling, we examined tumor specimens from 125 patients with DLBCL, uniformly treated by either cyclophosphamideAdriamycin-vincristine-prednisone or methotrexate, doxorubicin, cyclophosphamide, vincristine, prednisone, and bleomycin in a multicenter trial set by the Nordic Lymphoma Group 1989-1994. (aacrjournals.org)
The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. (cancerindex.org)
It has been known for many years that the fundamental transforming event in BL is the translocation of the MYC gene, and the events that bring about this translocation and those that allow cells to survive with the constitutive expression of MYC have been the subject of intense investigation. (bmj.com)
The hallmark of all BL tumours is the translocation between the MYC gene and one of the immunoglobulin (Ig) heavy or light chain loci. (bmj.com)
novel mutations in sh2d1a gene in x-linked lymphoproliferative syndrome, diagnosed after b-cell non-hodgkin lymphoma. (liverpool.ac.uk)
x-linked lymphoproliferative disease type i (xlp i) is caused by mutations in the sh2d1a gene and characterized mainly by hypogammaglobulinemia and abnormal response to epstein-barr virus with a high predisposition to b-cell non-hodgkin lymphoma development. (liverpool.ac.uk)

It arises from red marrow due to the monoclonal proliferation of plasma cells and manifests in a wide range of radiographic abnormalities. (radiopaedia.org)
EBVaGC is defined by monoclonal proliferation of carcinoma cells with latent EBV infection, as demonstrated by EBV-encoded small RNA (EBER) in situ hybridization. (spandidos-publications.com)

Solitary extramedullary plasmacytoma (SEP) is a neoplastic proliferation of a single clone of plasma cells that occur outside of the bone and bone marrow. (scielo.org.za)

2 Less commonly, non-small-cell lung cancer, lymphoma, prostate and bladder cancers have been reported. (reviewofophthalmology.com)
Other malignancies have occurred, including skin cancers and other solid tumors. (drugs.com)
Tumors or cancers of the KIDNEY. (lookformedical.com)
Chemotherapy, radiation therapy, and surgical removal of the tumors are standard methods implemented to cure breast cancers. (degruyter.com)
that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)

An elaborate network of signaling pathways orchestrates the communication between cancer cells and the surrounding stroma. (degruyter.com)

A heterogenous group of myeloid disorders characterized by somatically mutated hematopoietic stem cells,the presence of variable peripheral cytopenias, and a broad risk of progression to acute myeloid leukemia (AML). (standardofcare.com)
When the bone marrow hematopoietic cells are mostly clonally derived cells, the disease is clinically manifested as cytopenia and morphologic dysplasia. (standardofcare.com)
The paradox is that the mutation provides advantage at the stem cell level and progenitor cells, with a disadvantage at the level of hematopoietic precursors. (standardofcare.com)
Allogeneic double-negative T cell therapy for relapsed acute myeloid leukemia patients post allogeneic hematopoietic stem cell transplantation: A first-in-human phase I study. (ucdavis.edu)
However, because the thrombopoietin receptor is the only growth factor receptor in hematopoietic stem cells, thrombocytosis can occur before erythrocytosis. (msdmanuals.com)

We also discovered that the invasiveness of metastatic colon cancer cells was alleviated following drug treatment. (spandidos-publications.com)

Colorectal cancer (CRC) is one of the most prevalent neoplasms in the world, being the second type of cancer more frequent in women and the third type more frequent in men. (biorxiv.org)
Another important mechanism for the progression of colorectal cancer is the ability of the transformed cells to invade and traverse the basement membrane, which in turn facilitates the conversion of adenomas into carcinomas and then metastases ( 1 ). (spandidos-publications.com)

These lesions are considered to be independent primary lesions rather than metastatic disease when multiple tumors are encountered in the same patient. (allenpress.com)
At diagnosis half of the patients have a metastatic tumour and recurrence is very common. (hrb.ie)

Any discrete, presumably solitary, mass of neoplastic PLASMA CELLS either in BONE MARROW or various extramedullary sites. (lookformedical.com)
Extramedullary hematopoiesis may occur in the spleen, liver, and other sites that have the potential for blood cell formation. (msdmanuals.com)

A re-evaluation of solitary plasma cell myeloma of bone. (autopsyandcasereports.org)
Osseous solitary plasmacytoma of bone is a localized bone tumor of plasma cells, without evidence of plasma cell myeloma or marrow plasmacytosis. (medscape.com)
[ 1 ] Extraosseous solitary plasmacytoma of bone is a localized, soft-tissue plasma cell neoplasm that occurs in a location other than the bone and does not have evidence of plasma cell myeloma or marrow plasmacytosis. (medscape.com)
[ 6 ] In addition, plasma cell myeloma occurs more commonly in Americans of African descent than of European descent. (medscape.com)
It is also seen more commonly in males than females but presents in a younger patient than those with plasma cell myeloma, with a median age at diagnosis of 55 years. (medscape.com)
Plasma cell myeloma presents with generalized marrow involvement, with or without lytic lesions of bone. (medscape.com)
Anemia results from bone marrow replacement by plasma cell myeloma and/or the loss of erythropoietin as a result of renal injury. (medscape.com)

Pancreatic cancer (PC) is a highly aggressive tumor, often difficult to diagnose and treat. (bjbms.org)

In this review, we discuss the evidence linking LPA signaling to cancer-related inflammation and its impact on cancer progression. (hindawi.com)
We validate AP-1 complex differential expression (JUN and FOS) in plasma cell subpopulations using CyTOF-based protein assays, and integrated analysis of single-cell RNA and CyTOF data reveals AP-1 downstream targets (IL6 and IL1B) potentially leading to inflammation regulation. (wustl.edu)

The polymorphous infiltrate consists of lymphocytes of moderate size with pale/clear cytoplasm and smaller reactive lymphocytes, eosinophils, histiocytes, plasma cells, and follicular dendritic cells. (wikipedia.org)
Histologically, BL cells are monomorphic medium sized cells with round nuclei, a number of nucleoli and abundant cytoplasm. (bmj.com)

AITL typically has the phenotype of a mixture of CD4+ and CD8+ T-cells, with a CD4:CD8 ratio greater than unity. (wikipedia.org)
17 - 22 The cell surface phenotype of BL tumour cells reflects a GC origin but the site of tumour growth is frequently the jaw or ovary, neither of which normally contain GCs. (bmj.com)

2) The remaining contents will be sequestered in Rab7-positive late endosomes, which can fuse with the plasma membrane to form exosomes. (biomedcentral.com)

We present a functional analysis of TRIM13 using a loss-of-function approach, and demonstrate that TRIM13 downregulation decreases tumour cell survival as well as cell cycle progression and proliferation of MM cells. (huji.ac.il)
The survival of patients with CRC is directly associated with the pathological stage (pTNM) of the disease which is determined after microscope analysis of the sample obtained by biopsy or surgical resection of the tumor 2 , 3 . (biorxiv.org)
A systematic review and meta-analysis of randomized studies has shown a significant benefit with single ASCT in terms of prolonged progression-free survival (PFS), but not of overall survival (OS). (bvsalud.org)
Unrelated cord blood transplantation vs. HLA-matched sibling transplantation for adults with B-cell acute lymphoblastic leukemia in complete remission: superior OS for patients with long-term survival. (ucdavis.edu)
Chimeric Antigen Receptor T Cell Therapy followed by Unrelated Cord Blood Transplantation for the Treatment of Relapsed/Refractory B Cell Acute Lymphoblastic Leukemia in Children and Young Adults: Superior Survival but Relatively High Post-Transplantation Relapse. (ucdavis.edu)

Tumor specimens from 259 NSCLC patients were collected and analyzed. (cancerindex.org)
Fresh human cervical tissue specimens (n = 165) and four human cervical cell lines were tested for ClC-3 mRNA and protein expression levels by quantitative real-time PCR and western blotting. (biomedcentral.com)
Results identified elevated CR-1 expression in esophageal squamous cell carcinoma (ESCC) specimens which correlated to poor prognosis of the patients. (cusabio.com)

Indeed, the principal adipocytes isolated from obese mice could induce antigen-specific Compact disc4+ T cell activation (58). (exposed-skin-care.net)
indicated that ATMs colocalized with T cells in lymphoid clusters within adipose tissue and may act as APCs, which express high levels of MHCII and also costimulatory molecules and process and present antigens to induce CD4+ T-cell proliferation and activation in adipose tissue of obese mice (29, 68, 105). (exposed-skin-care.net)
Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included. (lookformedical.com)

Tumours display a "starry sky" pattern owing to the presence of high numbers of macrophages, which phagocytose apoptotic debris. (bmj.com)
Another statement showed the preadipocyte- and endothelial cell-derived stromal-derived element-1 (CXCL12), mediated early infiltration of CD4+ T lymphocytes in obesity, which preceded the increase of macrophages in adipose cells of mice on HFD (101). (exposed-skin-care.net)

Pituitary adenomas (PA) are commonly occurring benign neoplasms. (cancerindex.org)
[ 3 ] Occasionally, however, these lesions may result from an increase in the number of cells, which can range from benign nevi to fatal oral melanoma . (medscape.com)

The mechanism for Epstein-Barr virus infection of progenitor cells and neoplastic transformation has been an area of interest and conjecture. (allenpress.com)
Our findings propose a potential mechanism of VES-mediated anti-tumour activity and support the role of vitamin E analogs as potential chemopreventative agents against prostate cancer. (positivehealth.com)
Taken together, one important mechanism for obese adipose CD4+ T cell activation may be mediated through MHCII expressed on ATMs and adipocytes. (exposed-skin-care.net)
The mechanism for CD8+ T cell activation in adipose tissue is not fully understood. (exposed-skin-care.net)

urgent intervention indicated Definition:A dysfunction characterised by insufficiently wholesome hematapoietic cell manufacturing by the bone marrow. (ehd.org)
A normocellular microscopical appearance, with no plasma cell dyscrasia, was displayed on the bone marrow aspirate. (scielo.org.za)
Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. (lookformedical.com)
Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells. (lookformedical.com)
chronic myeloid leukemia (cml) is characterized by increased and unregulated proliferation of granulocytic lineage in the bone marrow and presence of these immature myeloid cells in the peripheral blood with presence of philadelphia (ph) chromosome. (liverpool.ac.uk)

Angioimmunoblastic T-cell lymphoma (AITL, sometimes misspelled AILT, formerly known as "angioimmunoblastic lymphadenopathy with dysproteinemia": 747 ) is a mature T-cell lymphoma of blood or lymph vessel immunoblasts characterized by a polymorphous lymph node infiltrate showing a marked increase in follicular dendritic cells (FDCs) and high endothelial venules (HEVs) and systemic involvement. (wikipedia.org)
citation needed] The typical patient with angioimmunoblastic T-cell lymphoma (AITL) is either middle-aged or elderly, and no gender preference for this disease has been observed. (wikipedia.org)
1 BL tumour cells usually express IgM, 13 - 15 B-cell markers such as CD19, CD20 and CD22 and markers of germinal centre (GC) centroblasts such as CD10, BCL6 4 and the human germinal centre-associated lymphoma (HGAL) protein. (bmj.com)
Subsequent studies revealed that EBV caused a number of different human malignancies, such as nasopharyngeal carcinoma (NPC), Hodgkin's lymphoma, extranodal NK/T-cell lymphoma, nasal type and lymphoproliferative disorders of immunocompromised hosts ( 2 ). (spandidos-publications.com)
Mantle cell lymphoma (MCL) who have received at least one prior therapy. (drugs.com)
CALQUENCE is indicated for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. (drugs.com)
plasma epstein-barr virus dna for pediatric burkitt lymphoma diagnosis, prognosis and response assessment in malawi. (liverpool.ac.uk)
In lymphomas I have conducted studies in rare aggressive primary cutaneous tumors such as gamma/delta T cell lymphoma (expanding the description of the epidermotropic variant) as well as more indolent entities such as lymphomatoid papulosis (type D) and CD4-positive small to medium size T cell lymphoproliferative disorders. (mdanderson.org)
This enabled identification of TFs that can be uniquely associated to the tumor cells of chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), hairy cell leukemia (HCL), and mantle cell lymphoma (MCL). (lu.se)

In women who present with gastrointestinal carcinomatosis but without an obvious pelvic mass, an extensive search often fails to identify a primary tumor. (medscape.com)
1 The primary tumor accounting for the vast majority of CAR cases is small-cell lung carcinoma, followed by gynecologic (ovarian, endometrial and cervical) and breast malignancies. (reviewofophthalmology.com)
Gliomas, the most common primary brain neoplasms in adults, are very heterogeneous tumors. (ajnr.org)
A primary malignant neoplasm of epithelial liver cells. (lookformedical.com)

Indeed, CD8+ T cells from mouse adipose tissue respond to cytokines and become activated and proliferate under stimulation of IL-12 and IL-18, which are mainly produced by APCs and are elevated in obese adipose tissue (44). (exposed-skin-care.net)

A detailed pathologic and molecular characterization of this tumor/entity was first described by Deyrup et al. (allenpress.com)

To investigate MM and its immune environment, we apply single cell RNA and linked-read whole genome sequencing to profile 29 longitudinal samples at different disease stages from 14 patients. (wustl.edu)
Here, we collect 17,267 plasma cells and 57,719 immune cells, discovering patient-specific plasma cell profiles and immune cell expression changes. (wustl.edu)
Patients with the same genetic alterations tend to have both plasma cells and immune cells clustered together. (wustl.edu)
By this process, tumor cells expressing antigenic epitopes with retinal photoreceptors elicit an immune response that cross-reacts with the retina, disrupting normal signal transmission. (reviewofophthalmology.com)
5) Lysosomes can also fuse with the plasma membrane to mediate membrane repair or discharge contents outside the cell, such as cathepsins or immune factors. (biomedcentral.com)

We conducted a systematic review of the literature on the effects of vitamin D on ovarian cancer cell. (mdpi.com)
The pTNM stage is a system of stage classification proposed by the American Joint Committee on Cancer which determines the degree of tumor development according with the T, N and M categories. (biorxiv.org)
DRAM2 acts as an oncogene in non-small cell lung cancer and suppresses the expression of p53. (cancerindex.org)
Here, we show that DRAM2 may act as an oncogenic regulator in non-small cell lung cancer (NSCLC). (cancerindex.org)
The most common type of cervical cancer is squamous cell carcinoma (SCC), which develops from low-squamous intraepithelial lesions (LSIL) and high-squamous intraepithelial lesions (HSIL). (biomedcentral.com)
There is a growing body of scientific evidence that suggests the potential implication of periodontitis in the causation and progression of various systemic disease and conditions, such as diabetes, cardiovascular disease, pulmonary disease, adverse pregnancy outcomes and cancer. (intechopen.com)
In this study, we aimed to evaluate the possible effects of tumor-stromal interactions on local estrogen biosynthesis in endometrial cancer. (scirp.org)
We isolated stromal cells from endometrial cancer patients to examine local biosynthesis of estrogens and tumor-stromal interactions. (scirp.org)
Next we examined the effects of steroid sulfatase inhibitor and aromatase inhibitor in monoculture of endometrial cancer cell line (Ishikawa) and in a co-culture system involving an Ishikawa cells and stromal cells. (scirp.org)
Estrogen receptor and steroid sulfatase mRNA levels in cancer cells were significantly higher in the co-cultures compared with the monocultures of endometrial cancer cells. (scirp.org)
Proliferation of the cancer cells was significantly increased through the steroid sulfatase pathway, which metabolizes androgens, estrone sulfate, and estradiol sulfate as its substrates. (scirp.org)
We evaluated the effects of STS inhibitor and aromatase inhibitors on the proliferation of estrogen-dependent endometrial cancer cells. (scirp.org)
Our previous findings demonstrated that formononetin initiates growth-inhibitory and pro-apoptotic activities in human colon cancer cells. (spandidos-publications.com)
In recent years, we focused on investigating the anti-carcinogenic properties of total Astragalus saponins (AST) in human colon cancer cells and tumor xenografts. (spandidos-publications.com)
Subsequent study using multiple human cancer cell lines, including those of the colon, stomach and liver, further indicated the universal growth-inhibitory and pro-apoptotic effects of AST. (spandidos-publications.com)
Selenium has been reported to inhibit the growth of prostate cancer cells in vitro. (positivehealth.com)
Here we review the retinal-based paraneoplastic syndromes, specifically cancer-associated retinopathy, melanoma-associated retinopathy (a lesser-known entity), paraneoplastic vitelliform maculopathy and bilateral diffuse uveal melanocytic proliferation. (reviewofophthalmology.com)
Identification of several targets of miRNAs associated with cancer suggests that networks of miRNAs linked to oncogenes or tumor suppressors play pivotal roles in cancer development. (genengnews.com)
Use of recombinant microRNAs as antimetabolites to inhibit human non-small cell lung cancer. (ucdavis.edu)
Tumors or cancer of the LIVER. (lookformedical.com)
Tumors or cancer of the PANCREAS. (lookformedical.com)
Tumors or cancer of the SKIN. (lookformedical.com)
CR-1 high cells isolated from ESCC cells possess cancer stem-like cells (ECSLC) properties. (cusabio.com)
Transcriptomic profiling of T-cell populations in non-muscle invasive and muscle invasive bladder cancer. (lu.se)
One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)

In this research, we explore the ClC-3 expression in cervical carcinoma and its underlying clinical significance, trying to illuminate ClC-3 probable function in the neoplasm malignant behavior, development and prognosis. (biomedcentral.com)

we evaluated plasma epstein-barr virus (pebv) dna as a pediatric bl biomarker in malawi. (liverpool.ac.uk)

Transwell migration, cell cycle analysis, MTT and colony formation assays were performed to determine the effect of DRAM2 overexpression and knockdown on NSCLC-cell migration and proliferation. (cancerindex.org)

Epstein-Barr virus-associated smooth muscle tumor is an uncommon neoplasm associated with immunodeficiency. (allenpress.com)
1 Subsequently, Chadwick et al 2 reported SMT in human immunodeficiency virus (HIV)-infected children and asserted the association between HIV and these rare neoplasms. (allenpress.com)

IARC WHO Classification of Tumours. (wikipedia.org)
The current standard for tumor grading is histopathologic assessment of tissue, which has inherent limitations, such as sampling error, interobserver variation, and a wide variety of classification systems that are available, the most common of which is the WHO grading system. (ajnr.org)

Oxidant-induced phenotypic changes may thus significantly contribute to the key pathogenic role played by bronchial epithelial cells in inflammatory airway disorders such as asthma and COPD. (biomedcentral.com)
It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (lookformedical.com)

Conditions characterized by the presence of M protein (Monoclonal protein) in serum or urine without clinical manifestations of plasma cell dyscrasia. (lookformedical.com)
Neoplasms containing cyst-like formations or producing mucin or serum. (lookformedical.com)

Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. (cancerindex.org)
DRAM2 overexpression also increased proteins CDK4, CyclinD3, and decreased p27 expression, all of which are cell cycle-related factors. (cancerindex.org)
VES supplementation also decreases the expression of anti-apoptotic XIAP and Bcl-X(L) proteins and sensitizes androgen-dependent LNCaP cells to androgen deprivation. (positivehealth.com)

Epstein-Barr virus-associated SMT is an uncommon soft tissue neoplasm affecting both adult and pediatric populations. (allenpress.com)

Different anatomic sites can be involved by Epstein-Barr virus-associated smooth muscle tumor, and even multiple locations can contain these unique lesions within the same patient. (allenpress.com)
Lesions appear in different areas of the body and have a different clinical progression 18,30 . (bvsalud.org)

Herein we present clear evidence that not only do both patient MM cells and human MM cell lines (HMCLs) release MVs, but that these MVs stimulate MM cell growth. (oncotarget.com)

The tumor tends to occur mainly in one location in most patients, but simultaneous occurrences in multiple sites have been reported. (allenpress.com)
3 In contrast to sBL, which most frequently involves tumours of the abdomen, 4 eBL often presents in the jaw or kidneys 10 11 but may also occur in the abdomen, ovaries, facial bones and other extranodal sites. (bmj.com)
Although defects may occur in many steps in B-cell development and maturation, resulting in agammaglobulinemia, the most common and well-described defect is the impaired maturation of the pro-B cells to pre-B cells. (medscape.com)

Therefore, the aim of this study was to evaluate, in the human lung adenocarcinoma cell line GLC-82, the effects of a 24-hour treatment with simvastatin on hydrogen peroxide (H 2 O 2 )-induced changes in cell viability, ERK phosphorylation, matrix metalloproteinase (MMP) expression, innate immunity signaling, NF-κB activation and IL-8 secretion. (biomedcentral.com)

It accounts for 1% of all malignancies and 10-15% of all hematological neoplasms 12,14 . (radiopaedia.org)

Anatomy32

Organisms9

Diseases60

Chemicals and Drugs66

Analytical, Diagnostic and Therapeutic Techniques and Equipment44

Phenomena and Processes47

Disciplines and Occupations1

Information Science4

Health Care5

Metastasis22

Apoptosis9

Biomarkers4

Angiogenesis8

Microenvironment10

Disease progression7

Invasion2

Clonal14

Tissues9

Multiple Myeloma7

Development and progression5

Genes3

Differentiation7

Therapeutic9

Prognostic4

Inhibits3

Carcinogenesis1

Malignancy4

Human tumour3

Mucinous1

Cellular2

Bone neoplasm1

Myeloproliferative neoplasm2

Vascular5

Gene7

Monoclonal proliferation2

Neoplastic proliferation1

Cancers5

Pathways1

Hematopoietic5

Invasiveness1

Colorectal cancer2

Metastatic2

Extramedullary2

Myeloma7

Pancreatic Cancer1

Inflammation2

Cytoplasm2

Phenotype2

Exosomes1

Survival5

Specimens3

Induce3

Macrophages2

Benign2

Mechanism4

Marrow5

Lymphoma9

Primary4

Cytokines1

Molecular1

Immune5

Cancer25

Prognosis1

Biomarker1

Knockdown1

Immunodeficiency2

Classification2

Epithelial cells2

Serum2

Proteins3

Soft-tissue1

Lesions2

Growth1

Occur3

Adenocarcinoma1

Hematological1