• Sex cord-gonadal stromal tumour is a group of tumors derived from the stromal component of the ovary and testis, which comprises the granulosa, thecal cells and fibrocytes. (wikipedia.org)
  • This tumour produces granulosa cells, which normally are found in the ovary. (wikipedia.org)
  • Although both cell types normally occur in the testicle, this tumour can occur in the ovary. (wikipedia.org)
  • With sex cord-stromal ovarian cancer , Ovarian refers to " ovary ", of which women have two that sit along either side of the uterus . (osmosis.org)
  • Adult-type granulosa cell tumors of the testicle are much less common than in the adult female ovary. (medscape.com)
  • To achieve better definition of these tumors, we examined the histologic, histochemical, and ultrastructural features of four unclassified SCSTs with spindle-cell features, and compared their immunohistochemical features with those of 24 other SCSTs of the testis and ovary. (elsevierpure.com)
  • The LCOHs also include carcinosarcomas (malignant mixed Müllerian tumors of the ovary), borderline epithelial tumors (also known as low malignant potential tumors), malignant sex cord-stromal tumors, and malignant germ cell tumors. (nebraska.edu)
  • The LCOHs also include carcinosarcomas (malignant mixed M{\"u}llerian tumors of the ovary), borderline epithelial tumors (also known as low malignant potential tumors), malignant sex cord-stromal tumors, and malignant germ cell tumors. (nebraska.edu)
  • Mutation of FOXL2 in granulosa-cell tumors of the ovary. (cancercentrum.se)
  • A current perspective on the pathological assessment of FOXL2 in adult-type granulosa cell tumours of the ovary. (cancercentrum.se)
  • The prevalence and prognostic impact of lymph node metastasis in malignant germ cell tumors of the ovary. (cancercentrum.se)
  • Prognostic impact of lymphadenectomy in clinically early stage malignant germ cell tumour of the ovary. (cancercentrum.se)
  • Pectasides D, Pectasides E, Psyrri A. Granulosa cell tumor of the ovary. (cancercentrum.se)
  • Retroperitoneal nodal metastasis in primary and recurrent granulosa cell tumors of the ovary. (cancercentrum.se)
  • Ayhan A, Salman MC, Velipasaoglu M, Sakinci M, Yuce K. Prognostic factors in adult granulosa cell tumors of the ovary: a retrospective analysis of 80 cases. (cancercentrum.se)
  • Patterns of metastasis in sex cord-stromal tumors of the ovary: can routine staging lymphadenectomy be omitted? (cancercentrum.se)
  • Surgical staging and adjuvant chemotherapy in the management of patients with adult granulosa cell tumors of the ovary. (cancercentrum.se)
  • Patterns of spread and recurrence of sex cord-stromal tumors of the ovary. (cancercentrum.se)
  • Stromal tumors of the ovary include germ-cell tumors, sex-cord stromal tumors, and other more rare types. (medscape.com)
  • Leydig cell tumour. (wikipedia.org)
  • This tumour produces Leydig cells, which normally are found in the testicle and tend to secrete androgens. (wikipedia.org)
  • This tumour produces both Sertoli and Leydig cells. (wikipedia.org)
  • A very rare tumour producing both ovarian (granulosa and/or theca) and testicular (Sertoli and/or Leydig) cells or tissues. (wikipedia.org)
  • citation needed] Granulosa cell tumors and Sertoli-Leydig cell tumors have specific genetic mutations that are characteristic and can help support the diagnosis. (wikipedia.org)
  • Low magnification micrograph of a Leydig cell tumour. (wikipedia.org)
  • A retrospective study of 83 women with sex cord-stromal tumours (73 with granulosa cell tumour and 10 with Sertoli-Leydig cell tumour), all diagnosed between 1975 and 2003, reported that survival was higher with age under 50, smaller tumour size, and absence of residual disease. (wikipedia.org)
  • Some of these tumors are granulosa-theca cell tumors and Sertoli-Leydig cell tumors. (osmosis.org)
  • Sertoli-Leydig cell tumors can secrete excess testosterone , which can cause women to have more masculine features like hirsutism , which is increased hair growth. (osmosis.org)
  • Testicular sex cord stromal tumors include Leydig cell tumors, Sertoli cell tumors, and granulosa cell tumors. (medscape.com)
  • Leydig cell tumors (see the image below) are derived from normal Leydig cells that produce testosterone and are located in the interstitium of the testis. (medscape.com)
  • Leydig cell tumors constitute about 3% of testicular neoplasms and occur in both adults (80% of cases) and children. (medscape.com)
  • In boys, Leydig cell tumors are benign. (medscape.com)
  • Although variable staining for S-100 protein was found in 5 of the 12 other SCSTs (4 Leydig cell, 6 Sertoli-Leydig cell, and 2 unclassifiable ovarian SCSTs), reactivity for smooth muscle actin was present in only 1 Sertoli-Leydig cell tumor. (elsevierpure.com)
  • Leydig cell tumors (see the image below) are rare testicular tumors of the male gonadal interstitium that may be hormonally active and lead to feminizing or virilizing syndromes. (medscape.com)
  • Leydig cell tumors may be an incidental finding of a testicular mass on scrotal ultrasonography performed for other conditions. (medscape.com)
  • Radical orchiectomy was once the primary treatment for Leydig cell tumors, and it remains in use for malignant cases. (medscape.com)
  • When Leydig cell tumors are diagnosed and treated early, testicle-sparing surgery has proved to be a feasible and safe choice and could be regarded as first-line therapy. (medscape.com)
  • In a study of 20 patients with Leydig cell tumors who were treated with conservative surgery, follow-up for a mean of 15 years found 100% disease-free survival, with no local recurrences or metastases. (medscape.com)
  • Leydig cell tumors are rare testicular tumors of the male gonadal interstitium. (medscape.com)
  • Although uncommon, Leydig cell tumors comprise 1-3% of all testicular neoplasms. (medscape.com)
  • Leydig cell tumors are usually benign, but malignant variants also occur. (medscape.com)
  • Leydig cell tumors were once managed primarily with radical orchiectomy . (medscape.com)
  • The etiology of Leydig cell tumors remains unknown. (medscape.com)
  • Unlike germ cell testicular tumors, Leydig cell neoplasms are not associated with cryptorchidism . (medscape.com)
  • In the United States, Leydig cell testicular neoplasms are the most common sex cord-stromal tumors and comprise 1-3% of all testicular neoplasms. (medscape.com)
  • DICER1-related Sertoli-Leydig cell tumor and gynandroblastoma: Clinical and genetic findings from the International Ovarian and Testicular Stromal Tumor Registry. (nih.gov)
  • The tumour is almost exclusively benign and unilateral. (wikipedia.org)
  • If any of those cells starts to divide uncontrollably, it can either form a benign tumor which means that it doesn't invade nearby tissue or spread to other parts of the body , or it can be a malignant tumor which means that it can invade nearby tissue and spread to other parts of the body . (osmosis.org)
  • Compared with benign tumor cells, malignant tumor cells have key features like not having a clearly defined border or like having slightly less organized nuclei. (osmosis.org)
  • 5 cm) than benign tumors. (medscape.com)
  • The ovaries consist of different types of tissue ( epithelial , germ cells, and sex cord tissue), which may give rise to benign or malignant tumors . (amboss.com)
  • We report 23 cases of tumors of the salivary gland comprising 18 cases of carcinoma ex pleomorphic adenoma, four cases of carcinosarcoma of the parotid and one case of benign metastasizing pleomorphic adenoma. (ijpmonline.org)
  • Solitary or multiple benign hepatic vascular tumors, usually occurring in women of 20-50 years of age. (lookformedical.com)
  • Evaluation of prevalence and outcomes of serial tyrosine kinase inhibitor use in pediatric patients with advanced solid tumors. (dana-farber.org)
  • Generally, solid tumors are best treated with surgical excision, while systemic neoplastic processes (ie, systemic lymphoma, metastatic conditions) are most effectively managed with use of systemic chemotherapy. (kipdf.com)
  • A prospective study of ovarian sex cord-stromal tumours in children and adolescents began enrolling participants in 2005. (wikipedia.org)
  • He is Editor of the book "Rare Tumors in Children and Adolescents", Springer 2012. (comsbox.com)
  • Renshaw, AA, Gordon, M & Corless, CL 1997, ' Immunohistochemistry of unclassified sex cord-stromal tumors of the testis with a predominance of spindle cells ', Modern Pathology , vol. 10, no. 7, pp. 693-700. (elsevierpure.com)
  • Pathology and Genetics of Tumours of the Breast and Female Genital Organs. (cancercentrum.se)
  • A sex cord-gonadal stromal tumor that has_material_basis_in granulosa cells and arises from the sex cord stroma. (jax.org)
  • Ovarian endometrioid carcinomas simulating sex cord-stromal tumors: a study using inhibin and cytokeratin 7. (roche.com)
  • Serum AMH is undetectable in patients with congenital or acquired anorchidism, or with complete gonadal dysgenesis. (biomedcentral.com)
  • Low circulating levels of AMH may reflect primary testicular dysfunction, e.g. in certain patients with cryptorchidism, monorchidism, partial gonadal dysgenesis, or central hypogonadism. (biomedcentral.com)
  • Serum AMH measurements are useful, together with testosterone determination, in the diagnosis of patients with ambiguous genitalia: both are low in patients with gonadal dysgenesis, including ovotesticular disorders of sex development, testosterone is low but AMH is in the normal male range or higher in patients with disorders of androgen synthesis, and both hormones are normal or high in patients with androgen insensitivity. (biomedcentral.com)
  • Malignant tumors may occur and are usually sporadic (with one report of a malignant tumor associated with Carney syndrome ). (medscape.com)
  • Necrosis can be seen in malignant tumors. (medscape.com)
  • Malignant tumors are larger and may have areas of necrosis. (medscape.com)
  • For diagnosis of granulosa cell tumour, inhibin is under investigation. (wikipedia.org)
  • Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Intended Use", "Value": "Inhibin, alpha (MRQ-63) Rabbit Monoclonal Antibody is intended for laboratory use in the detection of the Inhibin, alpha protein in formalin-fixed, paraffin-embedded human tissue stained in qualitative immunohistochemistry (IHC) on BenchMark IHC/ISH instruments. (roche.com)
  • Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Background Information", "Value": "Inhibin is a peptide hormone that inhibits FSH secretion from the pituitary. (roche.com)
  • 2 Anti-inhibin alpha has demonstrated utility in the identification of sex cord stromal tumors and adrenal cortical tumors. (roche.com)
  • The expression of inhibin/activin subunits in the human adrenal cortex and its tumours. (roche.com)
  • Diagnostic value of inhibin immunoreactivity in ovarian gonadal stromal tumours and their histological mimics. (roche.com)
  • Production of inhibin A and inhibin B in human ovarian sex cord stromal tumors. (roche.com)
  • Immunohistochemical study of testicular sex cord-stromal tumors, including staining with anti-inhibin antibody. (roche.com)
  • Inhibin expression in ovarian tumors and tumor-like lesions: an immunohistochemical study. (roche.com)
  • Inhibin A is a sensitive and specific marker for testicular sex cordstromal tumors. (roche.com)
  • Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Principle", "Value": "Inhibin, alpha (MRQ-63) Rabbit Monoclonal Primary Antibody (this antibody) may be used as the primary antibody for immunohistochemical staining of formalin-fixed, paraffinembedded tissue sections. (roche.com)
  • In the adult male, the appraisal of the endocrine function of the gonadal axis usually relies on the assessment of serum levels of gonadotropins, testosterone and inhibin B. In pediatric ages, basal testosterone and gonadotropin levels may be largely uninformative. (biomedcentral.com)
  • Malignancy arising in mixed tumors of the salivary gland is a distinct entity that can occur sporadically or in association with a background of pleomorphic adenoma. (ijpmonline.org)
  • GU tract pathologies can arise potentially at any stage of a person's life: newborns and infants can start showing signs and symptoms of congenital GU abnormalities, early or delayed puberty can become a burden for adolescents, STDs remain a major public health concern in sexually active teens and adults, and the potential for gonadal or cervical malignancy is constantly looming in particular cases. (lecturio.com)
  • In humans, these tumors demonstrate variable degrees of malignancy and surgical resection is often curative. (kipdf.com)
  • And these are the most common malignant stromal tumors and they're associated with middle-aged women. (osmosis.org)
  • Produces a "barrel cervix" if the tumor encircles the cervix and invades the underlying stroma. (brainscape.com)
  • Therefore, it appears evident that the assessment of gonadal function and the definition of male hypogonadism should rely on the understanding of normal testicular physiology resulting from the integrated function of the tubular and interstitial compartments, and its developmental changes from fetal life through maturity [ 5 ]. (biomedcentral.com)
  • Their diagnosis is histological: only a biopsy of the tumour can make an exact diagnosis. (wikipedia.org)
  • Characterized byvtche presence of tumor necrosis, cytologic atypia and mitotic activity. (brainscape.com)
  • The term sex cord refers to an embryonic structures that develop into ovarian follicles and stromal cells are the connective tissue of any organ. (osmosis.org)
  • So a sex cord-stromal ovarian cancer is a type of tumor that develops from either ovarian follicle cells or connective tissue cells . (osmosis.org)
  • Sex cord-stromal ovarian cancer is a type of tumor that develops from either ovarian follicle cells, or connective tissue cells . (osmosis.org)
  • Taken together, the histologic, histochemical, immunohistochemical, and ultrastructural features of the spindle-cell tumors are similar to those of granulosa cell tumors. (elsevierpure.com)
  • Immunohistochemical Expression of Preferentially Expressed Antigen in Melanoma (PRAME) in the Uninvolved Background Testis, Germ Cell Neoplasia In Situ, and Germ Cell Tumors of the Testis. (harvard.edu)
  • Solitary tumors of the uterus which arise de novo from the mesenchymal cells of the myometrium. (brainscape.com)
  • This tumour produces theca of follicle, a tissue normally found in the ovarian follicle. (wikipedia.org)
  • Definitive diagnosis of these tumours is based on the histology of tissue obtained in a biopsy or surgical resection. (wikipedia.org)
  • Under the microscope, these tumors classically develop little fluid pockets scattered throughout the tissue that are called Call-Exner bodies. (osmosis.org)
  • A teratoma is a tumor made up of several different types of tissue , such as hair , muscle , teeth , or bone . (mdwiki.org)
  • Mature teratoma of the mediastinum: A horizontal slice of the resected tumor reveals fibrofatty tissue, calcified areas, and a few cystic spaces lined with smooth membrane and containing a hair. (mdwiki.org)
  • pHOD coordinates Italian protocols for soft tissue sarcoma (STS), lymphoma, very rare tumors, CNS tumors and new drugs. (comsbox.com)
  • An increase in the number of cells in a tissue or organ without tumor formation. (lookformedical.com)
  • Teratomas occur in the coccyx in about one in 30,000 newborns, making them one of the most common tumors in this age group. (mdwiki.org)
  • [5] Ovarian teratomas represent about a quarter of ovarian tumors and are typically noticed during middle age. (mdwiki.org)
  • In contrast, the epithelial cells originate from the outer epithelial lining surrounding the gonad while the germ cell tumors arise from the precursor cells of the gametes, hence the name germ cell. (wikipedia.org)
  • Arise from sex cord cells (e.g. (amboss.com)
  • Unclassified sex cord-stromal tumors (SCSTs) of the testis comprised predominantly of spindle cells can be difficult to classify. (elsevierpure.com)
  • Various cell lineages such as the epithelial glandular cells and the stromal spindle cells are involved. (ijpmonline.org)
  • Although these tumors usually secrete testosterone, the production of estrogen, progesterone, and corticosteroids has also been described. (medscape.com)
  • Prepubertal testicular tumours and efficacy of testicular preserving surgery. (nih.gov)
  • Finally, elevation of serum AMH above normal male prepubertal levels may be indicative of rare cases of sex-cord stromal tumors or Sertoli cell-limited disturbance in the McCune Albright syndrome. (biomedcentral.com)
  • They are often suspected of being malignant prior to operation, being solid ovarian tumours that tend to occur most commonly in post menopausal women. (wikipedia.org)
  • Sertoli cell tumors account for less than 1% of testicular tumors, and they occur both in children (15% of cases) and in middle-aged adults and can be malignant (about 10% of cases) in both. (medscape.com)
  • Estrogen excess and feminizing syndromes may occur from the peripheral aromatization of testosterone or from the direct production of estradiol by the tumor itself. (medscape.com)
  • The classical seminoma is composed of fairly well differentiated sheets or cords of uniform polygonal or round cells (seminoma cells), each cell having abundant clear cytoplasm, distinct cell membranes, a centrally placed round nucleus, and one or more nucleoli. (harvard.edu)
  • The occurrence of various malignancies suggests that this phenomenon is not very uncommon and should be looked for when reporting a mixed tumor. (ijpmonline.org)
  • Uncommonly, a similar but possibly distinct tumour, juvenile granulosa cell tumour, presents in pre-pubertal girls with precocious puberty. (wikipedia.org)
  • The juvenile type of this condition is a rare sex cord stromal tumor that occurs in males in the first few months of life. (medscape.com)
  • Tumors of the juvenile type are small and solid and contain multiple small cysts. (medscape.com)
  • Staining for S-100 protein and smooth muscle actin was also observed in three of six granulosa cell minors and both juvenile granulosa cell tumors. (elsevierpure.com)
  • Molecular genetics and immunopathologic analysis of bladder cancer have shown some abnormalities in a number of genes and proteins that have been implicated in the development and progression of such tumors, mainly in the p53 pathway. (ijpmonline.org)
  • Reactivity for S-100 protein and smooth muscle actin is characteristic of these tumors. (elsevierpure.com)