Loading...
  • Signaling
  • In addition, PERK signaling has been found to be an important factor in determining growth and angiogenesis of specific types of tumors, and was attributed to PERK-dependent regulation of the hypoxic stress response. (jove.com)
  • Pray to God for help or go after the pathogen that alters Rho G proteins that are the signaling cascade for insulin production, skin growth, stomach healing, endocrine functions. (freerepublic.com)
  • proteins
  • Interactions between cell-surface proteins help coordinate the function of neighboring cells. (jove.com)
  • It is becoming increasingly clear that interactions between transmembrane proteins on the surfaces of adjacent beta cells are important determinants of beta-cell function. (jove.com)
  • These approaches also alter levels of the intracellular domains of the targeted proteins and may prevent effects due to interactions between proteins within the same cell membrane to be distinguished from the effects of transcellular interactions. (jove.com)
  • It is based on coculture models developed by neurobiologists, who found that exposure of cultured neurons to specific neuronal proteins expressed on HEK293 (or COS) cell layers identified proteins important for driving synapse formation. (jove.com)
  • The HC11 cells differentiate and synthesize milk proteins in response to treatment with lactogenic hormones. (jove.com)
  • stem cell
  • Millman, whose laboratory is in the Division of Endocrinology, Metabolism and Lipid Research, began his research while working in the laboratory of Douglas A. Melton, PhD, Howard Hughes Medical Institute investigator and a co-director of Harvard's Stem Cell Institute. (vetscite.org)
  • Millman said more research is needed to make sure that the beta cells made from patient-derived stem cells don't cause tumors to develop - a problem that has surfaced in some stem cell research - but there has been no evidence of tumors in the mouse studies, even up to a year after the cells were implanted. (vetscite.org)
  • He said the stem cell-derived beta cells could be ready for human research in three to five years. (vetscite.org)
  • The stem cell issue is a crucial "sanctity of human life issue. (physiciansforlife.org)
  • It may be surprising to know that there have been hundreds of quiet advances in adult stem cell research, while the loud praise heaped on embryonic stem cells lacks scientific credibility. (physiciansforlife.org)
  • Small trials using younger donors and elderly recipients hint that mesenchymal stem cell transfers might reduce frailty. (the-scientist.com)
  • California's Proposition 71, approved in 2004, was designed to provide $3 billion for stem cell research but has met a vigorous legal challenge from opponents of the research. (latimes.com)
  • Amniotic stem cell research ducks the controversy because no embryos are destroyed. (latimes.com)
  • Amniotic-fluid stem cells, which are sloughed off by the fetus, are "a different kind of a stem cell," Atala said. (latimes.com)
  • In December, the Vatican issued a 32-page document, "Dignitatis Personae" ("The Dignity of a Person") in which it warned of of the ethical dilemmas posed by new developments in stem cell research. (wordpress.com)
  • At least 351 companies across the United States are marketing unapproved stem cell procedures at 570 individual clinics. (vetscite.org)
  • Likewise, young scientists excited about careers in stem cell research are concerned about going into this field, given the legal uncertainty. (mednews.com)
  • They are at the heart of the NIH mission, and they are the ones who stand to benefit the most, or lose the most, by the stem cell policies we are discussing today. (mednews.com)
  • tissue
  • Dr. Dario Fauza, coordinator of the surgical research laboratories at Children's Hospital Boston, has used the cells to grow tissue to repair defective diaphragms and tracheas in sheep. (latimes.com)
  • Adult stem cells are narrowly focused on replenishing specific types of tissue that wear out over a lifetime, such as skin, hair and blood. (latimes.com)
  • These cells, also sometimes referred to as multipotent or somatic stem cells, can develop into a limited number of specific cell types, depending upon the organ or tissue from which they are derived. (mednews.com)
  • These invasive cells move into surrounding tissue and eventually to bl. (bio-medicine.org)
  • These invasive cells move into surrounding tissue and eventually to blood vessels, which provide the cancer cells with a means of moving to other areas of the body. (bio-medicine.org)
  • We have micro-needles filled with growth factors and tissue that we insert into a tumor on an anesthetized mouse. (bio-medicine.org)
  • immune
  • It is approved not just as a TB vaccine, but also as a bladder cancer treatment that works by prompting an immune response to tumors. (fiercebiotech.com)
  • In previous mouse studies and a phase 1 trial in people, Faustman's team showed that BCG raises levels of an immune system modulator, tumor necrosis factor. (fiercebiotech.com)
  • The second step of the therapy addressed the immune cells?inability to present self-peptides, molecules that are required to halt the development of autoimmune diseases. (scientificamerican.com)
  • Glial
  • The production of new myelin in the brain-a function of non-neuronal glial cells-may be necessary for motor learning, a mouse study shows. (the-scientist.com)
  • Cancer Re
  • This latest study published in the journal Molecular Cell and funded by the Wellcome Trust, Cancer Research UK and the Association of International Cancer Research (AICR) is the first to identify the enzyme that can rid cells of WT1. (bio-medicine.org)
  • Cancer Research UK scientists have used imaging techniques as a new way to identify patients who could benefit from certain breast cancer treatments, according to a study published in Oncotarget. (vetscite.org)
  • Cellular
  • Urano's team found that by replacing or enhancing the enzyme in mouse cells, they strengthened the cellular membrane, stopped molecules from leaking into other parts of a cell and prevented cell death. (healthcanal.com)
  • genetic
  • With samples they had collected from families for the past 15 years, as well as additional data from the COG, Children's Hospital of Philadelphia scientists traced the genetic roots of many neuroblastomas to ALK mutations findings that open the door to genetic screenings for the disease as well as possible therapies. (bio-medicine.org)
  • occurs
  • A cell-death cascade was set off by a process that occurs when harmful molecules spill from one part of the cell into other areas where they don't belong. (healthcanal.com)
  • suggests
  • The new discovery suggests a personalized treatment approach to diabetes may be on the horizon - one that relies on the patients' own stem cells to manufacture new cells that make insulin. (vetscite.org)
  • A new study of the University of Cambridge anatomy collection suggests that the bodies of foetuses and babies were a "prized source of knowledge" by British scientists of the 18th and 19th centuries, and were dissected more commonly than previously thought and quite differently to adult cadavers. (vetscite.org)
  • membrane
  • Kanekura K, Ma X, Murphy JT, Zhu LJ, Diwan A, Urano F. IRE1 prevents endoplasmic reticulum membrane permeabiliation and cell death under pathological conditions. (healthcanal.com)
  • drugs
  • Then it would be possible to test the effects of diabetes drugs on the beta cells of patients with various forms of the disease. (vetscite.org)
  • That's because tumor cells with Menainv are so sensitive to EGF that even a small amount of EGF signal not blocked by the drugs may be enough to stimulate EGF receptors and promote tumor cell migration and metastasis. (bio-medicine.org)
  • Concentrating on a gene known as ALK, the scientists used a small-molecule inhibitor a technique common to many drugs to block abnormalities that apparently cause neuroblastomas. (bio-medicine.org)
  • Furthermore, they found some of the ALK mutations were sensitive to a tiny organic molecule known as TAE684, a discovery that may be useful in efforts to create drugs to staunch cancer growth. (bio-medicine.org)
  • treatments
  • Now, scientists working to find treatments for Wolfram syndrome have identified a gatekeeper that prevents those harmful molecules from spilling and triggering cell death. (healthcanal.com)
  • reveal
  • Scientists reveal the neural underpinnings-and muscles tightly linked with-the involuntary flexing of the pelvic floor, which comprises muscles that help us delay urination. (the-scientist.com)
  • protein
  • Elucidation of the roles of particular transcellular interactions by knockdown, knockout or overexpression studies in cultured beta cells or in vivo necessitates direct perturbation of mRNA and protein expression, potentially affecting beta-cell health and/or function in ways that could confound analyses of the effects of specific interactions. (jove.com)
  • We developed a system where beta cells are cultured on a layer of HEK293 cells expressing a protein of interest. (jove.com)
  • In this model, the beta-cell cytoplasm is untouched while extracellular protein-protein interactions are manipulated. (jove.com)
  • Scientists ID Protein Aiding Breast Can. (bio-medicine.org)
  • The protein (called Menainv) is present in invasive cells within a bre. (bio-medicine.org)
  • patients
  • Still today, patients in several clinical trials have been given beta cell transplants with some success. (vetscite.org)
  • ability
  • Tregs have the ability to halt this aberrant behavior, but effective methods for modulating their activity have yet to be found. (fiercebiotech.com)
  • less
  • And as WT1 expression is low in healthy adults, oncogenic expression of WT1 has been found to be tumour specific so targeting WT1 will be less damaging to the patient's general health. (bio-medicine.org)
  • But even if amniotic stem cells turn out to be less flexible, they still might be an important tool in the nascent field of regenerative medicine. (latimes.com)
  • Type
  • If damaged cells are replaceable, type 1 diabetics wouldn't need insulin shots. (vetscite.org)
  • There had been questions about whether we could make these cells from people with type 1 diabetes," Millman explained. (vetscite.org)
  • So far, we've been successful with every cell type we've attempted to produce from these stem cells," said study senior author Anthony Atala, director of the Institute for Regenerative Medicine at Wake Forest University School of Medicine in Winston-Salem, N.C. The report was published online by the journal Nature Biotechnology. (latimes.com)
  • The type of cell stress involved in Wolfram syndrome, as well as more common forms of diabetes, can contribute to multiple diseases," said principal investigator Fumihiko Urano, MD, PhD, the Samuel E. Schechter Professor of Medicine. (healthcanal.com)
  • levels
  • Dr Jorg Hartkamp and Dr Stefan Roberts have found that the protease HtrA2 can "clean" cells of the oncogene WT1, which is found at high levels in many leukaemias and solid cancers such as breast and lung cancer. (bio-medicine.org)
  • Cell death can result if there are inadequate levels of the enzyme that keeps potentially harmful molecules in the proper place. (healthcanal.com)
  • This explains its relative toxicity to beta cells, since these cells have relatively high levels of GLUT2. (wikipedia.org)
  • animals
  • Due to its high toxicity to beta cells, in scientific research, streptozotocin has also been long used for inducing insulitis and diabetes on experimental animals. (wikipedia.org)
  • study
  • The team plans to study HtrA2 further, to find out how it is inactivated in cancer cells (allowing WT1 to proliferate) and what other targets HtrA2 has. (bio-medicine.org)
  • If everything that people think about them turns out to be true, they'll be a powerful source for therapeutic cells," said Alan Russell, director of the McGowan Institute for Regenerative Medicine at the University of Pittsburgh, who wasn't involved in the study. (latimes.com)
  • The HC11 cell line has been employed as a model system for the study of regulation of mammary lactogenic differentiation both in vitro and in vivo 2 . (jove.com)
  • We found that mouse breast tumor cells that we engineered to contain Menainv were invasive, whereas cells that did not have Menainv were not," study primary co-author Evanthia T. Roussos, an M.D.-Ph.D. student, said in an Albert Einstein news release. (bio-medicine.org)
  • The study was published in the Dec. 8 issue of Developmental Cell . (bio-medicine.org)
  • formation
  • A phenotypic measure commonly used to determine the degree of lactogenic differentiation in mouse mammary epithelial cell cultures is the formation of dome shaped cell structures referred to as mammospheres 1 . (jove.com)
  • urine
  • Exosomes are cell-derived vesicles that are present in many and perhaps all eukaryotic fluids, including blood, urine, and cultured medium of cell cultures. (wikipedia.org)
  • diabetes
  • New evidence has emerged from studies in mice that short telomeres or "caps" at the ends of chromosomes may predispose people to age-related diabetes, according to Johns Hopkins scientists. (innovations-report.com)
  • This mimics early stages of diabetes in humans where cells have trouble secreting insulin in response to sugar stimulus," says Armanios. (innovations-report.com)
  • In beta cells from mice with short telomeres, they found disregulation of p16, a gene linked to aging and diabetes. (innovations-report.com)
  • results reminiscent of recent experiments performed with human embryonic stem cells (hESC), a renewable source of cells that hold great promise as a potential therapeutic treatment for type 1 diabetes. (jove.com)
  • A loss of functional beta cell mass is central to both major forms of diabetes 1-3 . (jove.com)
  • Thus, efforts to restore functional beta cell mass are paramount to the better treatment of and potential cures for diabetes. (jove.com)
  • The research, presented at the American Diabetes Association's Scientific Sessions in San Diego, examines the mechanism by which BCG restores regulatory T cells (Tregs). (fiercebiotech.com)
  • Due to its high toxicity to beta cells, in scientific research, streptozotocin has also been long used for inducing insulitis and diabetes on experimental animals. (wikipedia.org)
  • This suggested the drug's use as an animal model of diabetes, and as a medical treatment for cancers of the beta cells. (wikipedia.org)
  • fetal
  • For almost 30 years, scientists have demonstrated that human fetal ICCs transplanted under the kidney capsule of nude mice matured into functioning endocrine cells, as evidenced by a significant increase in circulating human C-peptide following glucose stimulation 1-9 . (jove.com)
  • Fetal liver kinase-1 (Flk-1) is a cell surface receptor protein that is commonly used as a marker for ESCs and EPCs. (wikipedia.org)
  • debris
  • Cleanascite™ selectively removes lipids, cell debris, lipoproteins, floating fats, impurities from cohn paste, transgenic milk, egg yolk and biological samples for pretreatment of samples prior to purification. (biotechsupportgroup.com)
  • Although HS shares certain common features with acne vulgaris, such as a tendency to clog skin follicles with skin cell debris, the condition otherwise lacks the defining features of acne and is therefore considered a distinct skin disorder. (wikipedia.org)
  • As scavengers, they rid the body of worn-out cells and other debris. (wikipedia.org)
  • serum
  • As such they are not suitable for tumor screening and localization, but valuable as adjuncts for medical follow-up care of tumor patients, where their serum level alterations may anticipate the clinical detection of tumor behavior by a lead time of 1 to 6 months before other methods. (spotidoc.com)
  • motility
  • These results suggest that inhibitory effects of melittin on breast cancer cell motility and migration may be related to the inhibition of mTOR pathway. (blogspot.co.nz)
  • marker
  • In addition, tumor marker levels are not altered in all people with cancer, especially if the cancer is early stage. (spotidoc.com)
  • Some tumor marker levels can also be altered in patients with noncancerous conditions. (spotidoc.com)
  • CD34 is another marker that can be found on the surface of ESCs and EPCs. (wikipedia.org)
  • mammalian
  • In the reticulocyte, as in most mammalian cells, portions of the plasma membrane are regularly internalized as endosomes, with 50 to 180% of the plasma membrane being recycled every hour. (wikipedia.org)
  • detection
  • Because of the multidisciplinary research field, detection and isolation difficulties, and different ways of classification, there is currently no consensus about the nomenclature of cell-derived vesicles including exosomes. (wikipedia.org)
  • 22 January ESA scientists report the detection, for the first definitive time, of water vapor on the dwarf planet, Ceres, largest object in the asteroid belt. (wikipedia.org)
  • humans
  • Investigations concerning Kupffer cells are hampered because in humans, Kupffer cells are only accessible for immunohistochemical analysis from biopsies or autopsies. (pre-diagnostics.com)
  • vascular
  • Tal1 gene is specifically found in the vascular endothelium and developing brain. (wikipedia.org)
  • However, the study found that Tal1 is actually required for vascular remodeling of the capillary network, rather than early endothelial development itself. (wikipedia.org)
  • A study found that in the beginning stages of mouse embryogenesis, commencing at embryonic day 7.5, HPCs are produced close to the emerging vascular system. (wikipedia.org)
  • Glucose
  • Like ICCs, transplantation of partially differentiated hESC generate glucose responsive, insulin producing cells, but in vitro genesis of insulin producing cells from hESC is much less robust 11-17 . (jove.com)
  • Streptozotocin is similar enough to glucose to be transported into the cell by the glucose transport protein GLUT2, but is not recognized by the other glucose transporters. (wikipedia.org)
  • targets
  • Ideally, therapeutic targets would improve both beta cell growth and function. (jove.com)
  • This method has been used previously to identify novel targets that modulate beta cell replication or function 5,6,8,9,16,17 . (jove.com)
  • specific
  • Dendritic cell-derived exosomes express MHC I, MHC II, and costimulatory molecules and have been proven to be able to induce and enhance antigen-specific T cell responses in vivo. (wikipedia.org)
  • assays
  • Transwell invasion and wound-healing assays showed that bee venom and melittin significantly inhibits the EGF-induced invasion and migration of breast cancer cells. (blogspot.co.nz)
  • blood vessels
  • In 1917, Florence Sabin first observer of blood vessels and red blood cells in the yolk sac of chick embryos occur in close proximity and time. (wikipedia.org)
  • With the exception of the blood vessels, dopamine in each of these peripheral systems is synthesized locally and exerts its effects near the cells that release it. (wikipedia.org)
  • mechanisms
  • Therefore, ConA-induced hepatitis is an ideal model to investigate the mechanisms and treatments of T-cell-dependent hepatotoxicity. (hindawi.com)
  • LDL modification and oxidation caused by water soluble radicals and copper oxidation is measured by gel filtration chromatography.Scientists find albumin is a significant source of antioxidation in copper initiated mechanisms. (biotechsupportgroup.com)
  • As with other alkylating agents in the nitrosourea class, it is toxic to cells by causing damage to the DNA, though other mechanisms may also contribute. (wikipedia.org)
  • cancer cells
  • It was confirmed the inhibitory effects of bee venom, melittin, and apamin on the EGF-induced invasion of breast cancer cells. (blogspot.co.nz)
  • 6 January - A new way to destroy metastasizing cancer cells traveling through the bloodstream has been discovered by researchers at Cornell University. (wikipedia.org)
  • mainly
  • Dopamine is synthesized in a restricted set of cell types, mainly neurons and cells in the medulla of the adrenal glands. (wikipedia.org)
  • production
  • Upon exposure to noxious chemicals including liquor, stellate cells enter a dangerous activated solemn in which they suit highly well-versed factories dedicated to collagen production. (hummercar.ru)
  • For example, mRNA in exosomes has been suggested to affect protein production in the recipient cell. (wikipedia.org)
  • compounds
  • Neither a total prevention of biofilm formation nor a complete eradication of a 42 h-old biofilm by any of the tested compounds and the honeys were found. (blogspot.co.nz)
  • molecules
  • Therefore, scientists that are actively researching the role that exosomes may play in cell-to-cell signaling, often hypothesize that delivery of their cargo RNA molecules can explain biological effects. (wikipedia.org)
  • Whereas
  • They are multipotent, which describes the ability to give rise to many cell types, whereas a pluripotent stem cell can give rise to all types. (wikipedia.org)
  • mouse
  • From rats and mice, they are difficult to isolate, and after purification, only approximately 5 million cells can be obtained from one mouse. (pre-diagnostics.com)
  • MeCP2308/y mice, a mouse model of Rett Syndrome (a syndromic autism), were found to have increased MHC Class I expression and a concurrent loss of OD plasticity during the critical period, which can be rescued by acute blockade of PirB. (stanford.edu)
  • Types
  • This condition cannot be effectively corrected through diet and exercise alone, as the panniculus consists of adipocytes and other supporting cell types shrunken to their minimum volume and diameter. (wikipedia.org)
  • Endothelial stem cells (ESCs) are one of three types of stem cells found in bone marrow. (wikipedia.org)
  • Although dopamine is also found in many types of food, it is incapable of crossing the blood-brain barrier that surrounds and protects the brain. (wikipedia.org)
  • body
  • The polyphenol compound found in oolong tea is very effective in controlling the fat metabolism of the body. (blogspot.com)
  • It activates certain enzymes and thus enhances the functions of the fat cells in human body. (blogspot.com)
  • The polyphenolic compound is also responsible for removal of free radicals in our body, thus saving us from potential harm that these free moving cells may pose to the human body. (blogspot.com)
  • The intralumenal endosomal vesicles become exosomes if the multivesicular body merges with the cell membrane, releasing the internal vesicles into the extracellular space. (wikipedia.org)
  • This property maintains unspecialized and undifferentiated cells within the body. (wikipedia.org)
  • Moderate severity acne is said to occur when a higher number of inflammatory papules and pustules occur on the face compared to mild cases of acne and are found on the trunk of the body. (wikipedia.org)