• Fetal ovaries contained sporadic stromal cells displaying intense StAR staining, particularly in the hilar region. (elsevierpure.com)
  • 2 Anti-inhibin alpha has demonstrated utility in the identification of sex cord stromal tumors and adrenal cortical tumors. (roche.com)
  • Production of inhibin A and inhibin B in human ovarian sex cord stromal tumors. (roche.com)
  • Immunohistochemical study of testicular sex cord-stromal tumors, including staining with anti-inhibin antibody. (roche.com)
  • Ovarian endometrioid carcinomas simulating sex cord-stromal tumors: a study using inhibin and cytokeratin 7. (roche.com)
  • Ovarian tumors include luteoma of pregnancy, arrhenoblastoma, hilar-cell tumor, masculinizing ovarian stromal cell tumor, and Krukenberg tumor. (health.am)
  • Finally, elevation of serum AMH above normal male prepubertal levels may be indicative of rare cases of sex-cord stromal tumors or Sertoli cell-limited disturbance in the McCune Albright syndrome. (biomedcentral.com)
  • Ovarian stromal tumors develop in the ovaries' structural connective tissue cells that produce the female hormones estrogen and progesterone. (moffitt.org)
  • however, stromal tumors represent only about 1% of all ovarian cancers. (moffitt.org)
  • This type of cancer is more prevalent in women over the age of 50, but roughly 5% of ovarian stromal tumors form in young girls. (moffitt.org)
  • Because stromal tumors develop in the ovarian cells that produce female hormones, the tumors often end up producing estrogen, which can result in abnormal vaginal bleeding. (moffitt.org)
  • Sometimes, ovarian stromal tumors can actually produce male hormones, which could cause regular menstruation to stop, or superfluous facial and body hair to grow or enlarge the clitoris. (moffitt.org)
  • Stromal tumors may be benign (noncancerous) or malignant (cancerous). (moffitt.org)
  • Thecomas and fibromas are examples of benign stromal tumors. (moffitt.org)
  • Moffitt's Gynecologic Oncology Program is home to a multispecialty team of surgeons, medical oncologists, reproductive endocrinologists and many other professionals, who specialize in treating all types of ovarian cancer , including stromal tumors. (moffitt.org)
  • But generally speaking, ovarian stromal tumors are frequently discovered early and can be surgically treated. (moffitt.org)
  • To speak with a Moffitt oncologist specializing in the treatment of ovarian stromal tumors, call 1-888-663-3488 or complete our new patient registration form online. (moffitt.org)
  • The neocortex of the fetal adrenal glands displayed only minimal StAR staining, whereas moderate to intense staining was found in the fetal zone. (elsevierpure.com)
  • A Pheochromocytoma is a tumor of the medulla of the adrenal glands. (knowcancer.com)
  • The association of ambiguous genitalia and salt loss at birth signals on enzymatic block of the adrenal glands. (health.am)
  • The adrenal glands, via the hypothalamus-pituitary-adrenal (HPA) axis, also receive information about photoperiod changes and secrete adrenal steroids, primarily cortisol and dehydroepiandrosterone sulfate (DHEAS) [ 9 ]. (biomedcentral.com)
  • Studies in mice prove that light information is transmitted to the adrenal glands via the autonomic nervous system [ 10 ]. (biomedcentral.com)
  • Adrenal cortical adenomas, hyperplasias, and carcinomas all contained areas of StAR staining. (elsevierpure.com)
  • 1-2 In normal tissue, anti-inhibin alpha labels granulosa cells of the ovary, sertoli and leydig cells of the testis, and the zona reticularis of the adrenal cortex. (roche.com)
  • In the interstitial tissue, Leydig cells synthesize androgens and the insulin-like factor 3 (INSL3) [ 3 ], whereas in the seminiferous tubules, Sertoli cells regulate the nutrients and factors that reach the germ cells by means of the blood-testis barrier. (biomedcentral.com)
  • Analysis of XY byg/byg gonads at 11.5 d post coitum reveals a growth deficit and a failure to support mesonephric cell migration, both early cellular processes normally associated with testis development. (plos.org)
  • Excessive androgen production can be traced back to the mother, placenta or the fetal adrenal gland. (health.am)
  • DICER1 syndrome, also known as DICER1-pleuropulmonary blastoma familial tumor predisposition syndrome, is a condition in which an individual is born with genetic changes that predispose him or her to develop benign and malignant tumors during childhood, through adolescence and, rarely, as an adult. (choa.org)
  • Nephrogenic rests, benign foci of embryonal kidney cells that persist abnormally into postnatal life, are considered to be Wilms tumor precursors. (nih.gov)
  • The mutation increases the overall risk for affected children to develop cancer or a number of benign tumors, especially at younger ages. (choa.org)
  • This gene, often called a tumor suppressor gene, cannot protect cells from becoming cancerous when it isn't working properly. (choa.org)
  • The genetic changes that cause this syndrome are found in the DICER1 gene, a tumor suppressor gene. (choa.org)
  • Wilms' tumor suppressor gene 1 (WT1) is the gene responsible for the developmental process of AGP. (biomedcentral.com)
  • The rate-limiting step in steroid hormone production in the adrenal cortex and gonads, the translocation of cholesterol from the outer to the inner mitochondrial membranes, is mediated by the steroidogenic acute regulatory protein (StAR). (elsevierpure.com)
  • CAH is the most frequent cause of androgen excess and ambiguous genitalia in the female newborn and the various forms of CAH are due to defects in the biosynthesis of cortisol, with the subsequent excessive ACTH production leading to an accumulation of adrenal androgens and steroid precursors. (health.am)
  • Adrenal androgens undergo peripheral conversion to testosterone and dihydrotestosterone, and steroid precursors produce specific findings depending upon the exact enzyme deficiency. (health.am)
  • Primordial germ cells migrate to the gonadal ridge prior to 6 weeks and the infrastructure to support gonad development is further influenced by various genes. (pediatricurologybook.com)
  • We conclude that StAR is localized to normal and neoplastic cells in the gonads and adrenal cortex, which produce large amounts of pregnenolone. (elsevierpure.com)
  • The expression of inhibin/activin subunits in the human adrenal cortex and its tumours. (roche.com)
  • Immunohistochemical staining of normal, hyperplastic, and neoplastic adrenal cortex with a monoclonal antibody against alpha inhibin. (roche.com)
  • At the same time, in these groups, there was an increase in the level of aromatase, malondialdehyde, cholesterol, and steroidogenic factor-1 (SF-1) expression in the adrenal cortex and an enhancement in histological lesions. (biomedcentral.com)
  • In mammals, the adrenal cortex and gonads share the exact developmental origin: the adreno-gonadal primordium (AGP). (biomedcentral.com)
  • The endocrine dependence of this tumor is well documented, and hormonal manipulation to decrease circulating androgens remains the basis for the treatment of advanced disease. (basicmedicalkey.com)
  • The presence of StAR in cells that do not express cholesterol side-chain cleavage enzyme cytochrome P450, including renal distal tubules, Sertoli cells, and fetal oocytes, suggests that StAR has roles in metabolic processes in addition to stimulating pregnenolone synthesis. (elsevierpure.com)
  • Wilms tumor (nephroblastoma), an embryonal malignancy of the kidney, is the most common renal tumor of childhood [ Fernandez et al 2021 ]. (nih.gov)
  • There was minimal to moderate staining in the adrenal glomerulosa and faciculata and minimal staining in the reticularis, while the medulla was negative. (elsevierpure.com)
  • Primordial follicles of adult ovaries did not contain STAR, whereas antral follicles stained intensely in the thecal layer, with occasional staining of granulosa cells. (elsevierpure.com)
  • This GeneReview is intended to help clinicians determine if a genetic basis can be identified in an individual with Wilms tumor in order to provide families with natural history and recurrence risk information. (nih.gov)
  • Briefly describe the clinical characteristics of Wilms tumor. (nih.gov)
  • Review the mechanisms of predisposition to Wilms tumor. (nih.gov)
  • Provide an evaluation strategy to determine if a proband with Wilms tumor has a predisposition to Wilms tumor, identify the genetic or epigenetic mechanism for Wilms tumor, and determine risks for additional medical complications. (nih.gov)
  • Review management (e.g., tumor screening) recommendations for individuals with a genetic predisposition to Wilms tumor. (nih.gov)
  • Approximately 5%-10% of individuals with Wilms tumor have bilateral or multicentric tumors. (nih.gov)
  • The prevalence of bilateral involvement is higher in individuals with a predisposition to Wilms tumor than in those without a genetic predisposition (see Mechanisms of Predisposition to Wilms Tumor ), but unilateral, unifocal Wilms tumor does not preclude an underlying germline or epigenetic cause. (nih.gov)
  • A definitive diagnosis of Wilms tumor can be made only on histologic assessment of the tumor. (nih.gov)
  • Additional pathogenic variants transform nephrogenic rests into a Wilms tumor [ Fernandez et al 2021 ]. (nih.gov)
  • In 10%-15% of individuals with Wilms tumor, the cause is considered to be a germline pathogenic variant or an epigenetic alteration occurring early during embryogenesis [ Mahamdallie et al 2019 ]. (nih.gov)
  • Clinical features of Wilms tumor predisposition syndromes (See Table 1 and Table 2 . (nih.gov)
  • Approximately 1%-2% of individuals with Wilms tumor have at least one relative also diagnosed with Wilms tumor. (nih.gov)
  • The prognosis for prostate cancer patients depends on the histologic grade, the tumor size, and the disease stage. (basicmedicalkey.com)
  • Moreover, we describe experiments showing the presence of activated MKK4, a direct target of MAP3K4, and activated p38 in the coelomic region of the XY gonad at 11.5 d post coitum, establishing a link between MAPK signalling in proliferating gonadal somatic cells and regulation of Sry expression. (plos.org)
  • Inhibin expression in ovarian tumors and tumor-like lesions: an immunohistochemical study. (roche.com)
  • They are broken down into many subtypes, which are determined by a number of the tumors' features, such as how their cells look under a microscope. (moffitt.org)
  • Untreated maternal virilizing CAH is another potential cause, though androgen-secreting adrenal tumor in the mother is rare. (health.am)
  • 1 This newer classification incorporates a wide range of conditions, including congenital adrenal hyperplasia ( CAH ), ovotesticular DSD , androgen insensitivity syndrome ( AIS ). (pediatricurologybook.com)
  • Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Principle", "Value": "Inhibin, alpha (MRQ-63) Rabbit Monoclonal Primary Antibody (this antibody) may be used as the primary antibody for immunohistochemical staining of formalin-fixed, paraffinembedded tissue sections. (roche.com)
  • While sperm production has classically been the focus of adult reproductive function, somatic cells are crucial for the maintenance of spermatogenesis and gamete production. (biomedcentral.com)
  • Not all individuals with a diagnosis of DICER1 syndrome will develop tumors or cancer. (choa.org)
  • Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Intended Use", "Value": "Inhibin, alpha (MRQ-63) Rabbit Monoclonal Antibody is intended for laboratory use in the detection of the Inhibin, alpha protein in formalin-fixed, paraffin-embedded human tissue stained in qualitative immunohistochemistry (IHC) on BenchMark IHC/ISH instruments. (roche.com)
  • Acute lymphocytic leukemia (ALL) is a type of cancer of the blood and bone marrow - the spongy tissue inside bones where blood cells are made. (massivebio.com)
  • Closely related tumors include extra-adrenal paragangliomas. (knowcancer.com)
  • Specific maturational changes take place both in these organs as a whole and in the different cell types that make them up. (biomedcentral.com)
  • The gland consists of numerous cell types, which specialize in making and releasing specific hormones. (pharmaceuticalintelligence.com)
  • However, 20% of the time, this genetic change occurs on its own in an oocyte or sperm cell prior to fertilization. (choa.org)
  • Sertoli cells not only regulate the inflow of external substances, but also produce several substances which are critical to the proper progression of spermatogenesis [ 4 ]. (biomedcentral.com)
  • The exact origin, type, size, and stage of the tumor are all factors that determine a patient's prognosis. (knowcancer.com)