• o Investigation of the pathogenesis of neurofibromas, gliomas, malignant peripheral nerve sheath tumors, skeletal and cardiovascular abnormalities, learning disabilities, and other manifestations of NF. (nih.gov)
  • 9. Lipoblastic nerve sheath tumors: report of a distinctive variant of neural soft tissue neoplasm with adipocytic differentiation. (nih.gov)
  • It is a poorly defined benign tumor of the peripheral nerve sheath spreading out just under the skin or deeper in the body. (odermatol.com)
  • Malignant peripheral nerve sheath tumors (MPNSTs) and liposarcomas (LPS) are chemoresistant and have few effective treatment options. (oncotarget.com)
  • Using a comprehensive tissue microarray (TMA) of both benign and malignant tumors in primary, recurrent, and metastatic samples, we examined NY-ESO-1 expression in peripheral nerve sheath tumor (PNST) and adipocytic tumors. (oncotarget.com)
  • The mice develop either high-grade myogenic sarcomas or malignant peripheral nerve sheath tumor (MPNST)-like tumors, respectively. (duke.edu)
  • Myelin is an insulating layer, or sheath that forms around nerves, including those in the brain and spinal cord. (adam.com)
  • Furthermore, nerve sheath tumors of the trigeminal nerve rarely manifest with intermittent painful burning or crawling sensations simulating trigeminal neuralgia. (neurology-jp.org)
  • TPX2-p53-GLIPR1 regulatory circuitry in cell proliferation, invasion, and tumor growth of bladder cancer. (cancerindex.org)
  • This study aims to explore the interplay between TPX2, p53, and GLIPR1 and its correlation with cell proliferation, invasion, and tumor growth in bladder cancer. (cancerindex.org)
  • Treatment with PD325901 delays tumor growth through decreased cyclin D1 mRNA and cell proliferation. (duke.edu)
  • As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. (cancerindex.org)
  • Cells can accelerate repair while scaffolds provide the tissue engineered construct (TEC) with mechanical and structural integrity and guide cell proliferation and differentiation and protein synthesis. (asme.org)
  • His current research activities include nano- and micro-scale functionalization of biomimic three-dimensional scaffolds for neural and musculoskeletal tissue repair and regeneration, investigation of cell and material interactions in bioreactors, development of controlled release systems for the delivery of growth factors and drugs, manipulation of microenvironment for stem cell proliferation and differentiation. (stevens.edu)
  • Nerves infiltrate this cancerous environment early in tumor development. (nih.gov)
  • Nerves infiltrate this cancerous environment early on. (nih.gov)
  • Peptide hormone receptors overexpressed in human tumors, such as somatostatin receptors, can be used for in vivo targeting for diagnostic and therapeutic purposes. (snmjournals.org)
  • GLP-1 receptors were expressed in various endocrine tumors, with particularly high amounts in pheochromocytomas, as well as in brain tumors and embryonic tumors but not in carcinomas or lymphomas. (snmjournals.org)
  • The GLP-1 receptors may represent a novel molecular target for in vivo scintigraphy and targeted radiotherapy for a variety of GLP-1 receptor-expressing tumors. (snmjournals.org)
  • G protein-coupled peptide hormone receptors play an increasing role in cancer medicine. (snmjournals.org)
  • The somatostatin receptors were the first peptide receptors identified for these purposes, and somatostatin receptor targeting has now become an integral part of the routine management of patients with gastroenteropancreatic neuroendocrine tumors. (snmjournals.org)
  • Prompted by the success of somatostatin receptor targeting, we have evaluated the overexpression of other peptide receptor families in tumors in vitro ( 1 ), with the aim, eventually, of being able to target in vivo a larger spectrum of tumors or individual tumors more efficiently with multiple peptide analogs directed against different peptide receptors expressed in the same tumor ( 5 , 6 ). (snmjournals.org)
  • With the help of the imaging and magnification of microscopes (including fluorescence microscopes and electron microscopes), it can detect various antigenic substances (such as protein , polypeptide, enzymes, hormones, pathogens and receptors, etc. (ballyabio.com)
  • As a result, the introduction of drugs which can normalize growth-factor receptors and proteins are of great interest and the primary treatment given. (nfcr.org)
  • RTKs are single pass transmembrane receptors that possess intrinsic cytoplasmic enzymatic activity, catalyzing the transfer of the gamma phosphate of ATP to tyrosine residues in protein substrates. (affbiotech.cn)
  • Included in this large protein family are the insulin receptor and the receptors for growth factors such as epidermal growth factor, fibroblast growth factor and vascular endothelial growth factor. (affbiotech.cn)
  • This function is lost when the gene is mutated, enabling tumors to grow unrestrained. (nih.gov)
  • Immunohistochemistry ( ihc ), also known as immunocytochemistry , refers to a new technology that the qualitative, localized, and quantitative determination of the corresponding antigens is performed through antigen-antibody reaction and histochemical color reaction in tissue cells' situ by specific antibodies labeled with a chromogenic reagent. (ballyabio.com)
  • Therefore, immunohistochemistry is theoretically a specific display of antigens in tissue cells. (ballyabio.com)
  • NLGN3 expression in glioma tissue was semi-quantitatively assessed by immunohistochemistry. (amsterdamumc.org)
  • Immune read out was performed by fluorescent activated cell sorting analysis for effector T cells, regulatory T cells, natural killer cells, B cells, macrophages, and myeloid Cd99 derived suppressor cells (MDSC), immunohistochemistry for MDSC DM4 and tumor-associated macrophages (TAM) and immunofluorescence for M1 and M2 TAM in the vascular context. (baxkyardgardener.com)
  • Other than histologic and cytogenetic analysis, no specific laboratory tests exist for diagnosing soft-tissue tumors. (medscape.com)
  • Angiography to evaluate any vascular involvement by soft tissue tumors has essentially been replaced by MRI. (medscape.com)
  • [1] Molecular studies for translocations in soft tissue tumors reveal that SS can present in varied sites with varied histologic patterns. (ijpmonline.org)
  • Sensory neurons (a type of nerve cell) in culture that were exposed to p53-deficient oral cancer cells sprouted projections called neurites. (nih.gov)
  • Further experiments showed that growth cues come from tumors to neurons in the form of signaling molecules called microRNAs. (nih.gov)
  • These microRNAs nudge sensory neurons to reduce their normal gene activity and adopt genetic characteristics of a different class of nerve cells, known as adrenergic neurons, that are usually rare in the oral cavity. (nih.gov)
  • To confirm that the adrenergic neurons were promoting tumors, the scientists blunted adrenergic signaling in mice-either by disabling sensory nerves or giving adrenergic-blocking drugs. (nih.gov)
  • The resulting tumors were slower growing, smaller, and surrounded by fewer adrenergic-like neurons. (nih.gov)
  • Although MRI alone suffices for most patients, the information obtained from CT and MRI of the primary tumor occasionally may be complementary. (medscape.com)
  • Taken together, our results use a primary tumor model to show that sarcomas can be generated by loss of NF1 and Ink4a/Arf, and that these tumors are sensitive to MEK inhibition by direct effects on tumor cells and the surrounding microenvironment. (duke.edu)
  • It is important to recognize this entity in the head and neck region because the main stay of treatment is wide excision of the primary tumor and not chemotherapy or regional node dissection. (ijpmonline.org)
  • Although researchers have learned much from the study of this diverse group of tumors over the years, the diagnosis and treatment of salivary gland neoplasms remain complex and challenging problems for the head and neck surgeon. (medscape.com)
  • Soft-tissue sarcomas are a heterogeneous group of tumors arising from connective tissue. (duke.edu)
  • Sarcomas are a diverse and sporadic group of tumors that have minimal hereditary influence. (nfcr.org)
  • We also observed that ROBO1 and SLIT2 differentiated histopathological subgroups of liver tissues depending on both tumor staging and differentiation status. (bilkent.edu.tr)
  • We also provide quantitative evidence for potential use of ROBO1, ROBO4 and SLIT2 for prediction of tumor stage and differentiation status. (bilkent.edu.tr)
  • Spectral imaging of adipose tissue provides high-quality information involving molecular compositional, structural, and functional alterations for characterization and differentiation of adipocytes (brown, white) in different adipose tissue regions (visceral, subcutaneous, etc. (intechopen.com)
  • In this chapter, applications of spectroscopic and spectral imaging techniques for characterization and differentiation of various adipose tissues will be discussed, which will shed light to better understand adipose tissue metabolism and provide new insight into diagnosis and treatment of some metabolic diseases such as obesity. (intechopen.com)
  • Effective therapies must target both the tumor and its microenvironment-the supportive network of connective tissue, blood vessels, cells, and molecules that surround the tumor. (nih.gov)
  • These results suggest that loss of p53 in oral cancer enhances nerve growth and density in the tumor microenvironment. (nih.gov)
  • The scientists found that spherical delivery vehicles called extracellular vesicles were transferring the microRNAs from tumors to nerve cells in the microenvironment. (nih.gov)
  • That's because existing therapies treat only the tumor itself, and not its microenvironment, the network of connective tissue, blood vessels, cells, and molecules that surround it. (nih.gov)
  • Effective treatments must target both the tumor and its microenvironment, which mutually support each other through constant chemical crosstalk. (nih.gov)
  • The results suggested that loss of p53 in oral cancer enhances nerve growth and density in the tumor microenvironment. (nih.gov)
  • Considering that nerves are important members of the tumor microenvironment, we here establish different Ndrg4 knockout (Ndrg4 -/- ) CRC models and an indirect co-culture of primary enteric nervous system (ENS) cells and intestinal organoids to identify whether the ENS, via NDRG4, affects intestinal tumorigenesis. (nih.gov)
  • Targeting this nerve-tumor crosstalk could lead to more effective treatments for people with head and neck cancers. (nih.gov)
  • Scientists are trying to understand the tumor-nerve relationship in hope that it could lead to better therapies for head and neck cancer. (nih.gov)
  • Plexiform neurofibroma is a poorly circumscribed, diffuse enlargement of neural sheets that typically involves major nerve trunks of the head and neck region because of the rich innervations of this area. (odermatol.com)
  • Surgical management is the mainstay of treatment, but within the head and neck region it is limited by the infiltrating nature of these tumors, inherent operative morbidity and a high rate of regrowth. (odermatol.com)
  • Salivary gland neoplasms make up 6% of all head and neck tumors. (medscape.com)
  • When cancer forms a single solid tumour or mass, surgery can be straightforward, but what about when the cancer grows around other essential tissues and organs - especially in the head and neck? (totalhealth.co.uk)
  • RESEARCH OBJECTIVES Background The neurofibromatoses (NF) are autosomal dominant genetic disorders that cause tumors to grow along peripheral nerves. (nih.gov)
  • Katirji B. Disorders of peripheral nerves. (adam.com)
  • Hematogenous macrophages remove myelin debris from injured peripheral nerves to provide a micro-environment conducive to axonal regeneration. (johnshopkins.edu)
  • Previously, we observed that injured peripheral nerves from Beta-site APP Cleaving Enzyme 1 (BACE1) knockout (KO) mice displayed earlier influx of and enhanced phagocytosis by macrophages when compared to wild-type (WT) mice. (johnshopkins.edu)
  • The GLP-1 receptor protein expression was qualitatively and quantitatively investigated in a broad spectrum of human tumors ( n = 419) and nonneoplastic human tissues ( n = 209) with receptor autoradiography using 125 I-GLP-1(7-36)amide. (snmjournals.org)
  • To estimate the suitability of a peptide receptor for in vivo tumor targeting, one needs detailed in vitro data on its expression in human tumors and human normal tissues. (snmjournals.org)
  • Furthermore, approximately 50% of the methylated tumor samples shared methylation between two of the five genes (most commonly between EBF3 and IRX1), and 15% shared methylation between three of the five genes. (nih.gov)
  • Chromosome 11 likely contains 1,300 to 1,400 genes that provide instructions for making proteins. (nih.gov)
  • Over a decade ago, investigators identified the genes that cause NF1 and NF2 (neurofibromin and merlin/schwannomin respectively) and began to characterize their protein products. (nih.gov)
  • NF has served as an important paradigm for understanding how mutations in single genes can affect the development of multiple tissues. (nih.gov)
  • The expressions of mitochondrial function associated genes, MCU and UCP3, and mitochondrial fission genes, DRP1 and FIS1, were decreased by exendin-4 compared to non-treated levels, while the protein expression levels of mitochondrial homeostasis regulators, Parkin and PINK1, were enhanced. (bvsalud.org)
  • Genes that are altered by lithium treatment are involved in many functions such as cell communication, immune response, protein metabolism, nucleic acid regulation/metabolism, and cell growth. (zrtlab.com)
  • These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. (cancerindex.org)
  • The protein produced from the EWSR1/FLI1 fusion gene, called EWS/FLI, has functions of the protein products of both genes. (medlineplus.gov)
  • which is the first step in the production of proteins from genes. (medlineplus.gov)
  • The FLI protein controls the growth and development of some cell types by regulating the transcription of certain genes. (medlineplus.gov)
  • It is thought that the EWS/FLI protein turns the transcription of a variety of genes on and off abnormally. (medlineplus.gov)
  • Translocations that fuse the EWSR1 gene with other genes that are related to the FLI1 gene can also cause these types of tumors, although these alternative translocations are relatively uncommon. (medlineplus.gov)
  • In both mice and humans, adrenergic nerve fibers were denser in p53-deficient oral tumor tissue. (nih.gov)
  • On the basis of our results, new lines of research could open up on the link between embryonary stem cells and tumors in other animal models and also humans", commented Cayetano González. (irbbarcelona.org)
  • I had an excellent surgeon who removed all but 2% of the cancerous tissue. (cancer.org)
  • Gynecomastia (abnormal non-cancerous enlargement of one or both breasts in males due to the growth of breast tissue as a result of a hormone imbalance between estrogens and androgens). (justtheinserts.com)
  • Ewing sarcoma is a cancerous tumor that occurs in bones or soft tissues, such as cartilage or nerves. (medlineplus.gov)
  • The researchers found that in mouse models of oral cancer, animals lacking p53 had denser nerve networks around their tumors compared to control mice with p53. (nih.gov)
  • Only seven of spinal cord DEGs overlapped with DEGs from type 1 diabetic sciatic nerve and only a single gene cathepsin E (CTSE) was common for both type 1 and type 2 diabetic mice. (bvsalud.org)
  • Ink4a/Arf(flox/flox) mice at two distinct orthotopic sites: intramuscularly or in the sciatic nerve. (duke.edu)
  • MDSC activated by ID8-fLuc conditioned medium or ascites of tumor-bearing mice showed T cell suppressive functions = 0.006) and OS (= 0.02) (16). (baxkyardgardener.com)
  • B6.129P2(SJL)-Myd88tm1.1Defr/J are C57BL/6 mice which have a defect in the Myd88 cytosolic adapter, a proteins which takes on a central part in dendritic cells rate of metabolism and in the immunosuppressive function of MDSC by activating NADPH oxidase and arginase-1 (18, 19). (baxkyardgardener.com)
  • Ovarian tumor was induced in the mice by intraperitoneal (IP) administration of 5 106 Identification8-fLuc cells dissolved in 100 L cool Phosphate-Buffered Saline (PBS). (baxkyardgardener.com)
  • Bioluminescence Imaging (BLI) noninvasive bioluminescence imaging (BLI) was utilized to judge tumor burden in albino C57BL/6/BrDCHsd-Tyrc and C57BL/6J-Tyrc-2J/J mice. (baxkyardgardener.com)
  • In the CD8 T cell depletion experiment mice were scanned only scanned twice (week 1 and week 6 after tumor inoculation). (baxkyardgardener.com)
  • We started treating the mice 1 week after tumor challenge with CL IP twice a week at a dosage of 0.05 mg/g bodyweight. (baxkyardgardener.com)
  • To determine through which pathway BACE1 influences macrophage influx, we used a mouse inflammation antibody array to assay the expression of inflammation-related proteins in injured nerves of BACE1 KO and WT mice. (johnshopkins.edu)
  • Additionally, treatment of WT mice with a BACE1 inhibitor resulted in increased TNFR1 expression and signaling in the distal stump of injured nerves. (johnshopkins.edu)
  • The accelerated macrophage influx in injured nerves of BACE1 KO mice correlates with increased expression and signaling via TNFR1, indicating a link between BACE1 activity and TNFR1 expression/signaling that might contribute to repair of the injured nervous system. (johnshopkins.edu)
  • The team found that high nerve density and TP53 mutations in oral cancer tissue were associated with earlier death. (nih.gov)
  • The scientists began by analyzing patient data and found that TP53 mutations and high nerve density in oral cancer tissue were associated with earlier death. (nih.gov)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • Recently, mutations in the neurofibromin 1 (NF1) tumor suppressor gene were identified in multiple subtypes of human soft-tissue sarcomas. (duke.edu)
  • Spinal muscular atrophy (SMA) is a common neurodegenerative disease that is caused by mutations in the survival of motor neuron gene (SMN), leading to reduced levels of the SMN protein in affected individuals. (ox.ac.uk)
  • the group of tumor-specific reoccurring genetic mutations via specific and aberrant chromosome translocation, and the group of non-reoccurring mutations which are based on severe genetic and chromosomal instability. (nfcr.org)
  • These mutations prevent the body from making certain proteins that control how cells grow. (dana-farber.org)
  • This action results in reactivation of AMP-ACTIVATED PROTEIN KINASE activity and downstream signaling aimed at decreased metabolism. (nih.gov)
  • The adipokinome (which together with lipid moieties released, such as fatty acids and prostaglandins, constitute the secretome of fat cells) includes proteins involved in lipid metabolism, insulin sensitivity, the alternative complement system, vascular haemostasis, blood pressure regulation and angiogenesis, as well as the regulation of energy balance. (cambridge.org)
  • Scientists discovered a new role for nerves in oral cancer progression, in which tumor cells send genetic messages that transform nerves into cancer-promoting agents. (nih.gov)
  • Western blotting of protein extracts confirmed increased expression of TNFR1 and its downstream transcriptional factor NFκB in the BACE1 KO distal stumps. (johnshopkins.edu)
  • Past studies showed that these signals can also promote tumor progression in other cancers. (nih.gov)
  • So far though, progress has been stymied by scientists' lack of understanding of how cancer-associated nerves arise and promote tumor growth. (nih.gov)
  • 13. Cutaneous CD34+ spindle cell neoplasms: Histopathologic features distinguish spindle cell lipoma, solitary fibrous tumor, and dermatofibrosarcoma protuberans. (nih.gov)
  • Here, Western blot and qRT-PCR analysis revealed that TPX2 at both mRNA and protein levels was up-regulated in bladder carcinoma tissues compared to their paired adjacent normal tissues. (cancerindex.org)
  • For GLP-1 receptor scintigraphy, a low-background signal can be expected, on the basis of the low receptor expression in the normal tissues surrounding tumors. (snmjournals.org)
  • Equally important is a low receptor expression in normal tissues surrounding tumors, at sites of tumor origin and of metastasis, for receptor-targeted scintigraphy will detect tumors with adequate sensitivity only in the case of a high ratio of tumor to background signal ( 8 , 9 ). (snmjournals.org)
  • Moreover, knowledge of the distribution and putative functions of a peptide receptor in normal tissues is important to estimate the potential of side effects of a peptide therapy ( 10 ). (snmjournals.org)
  • The surrounding normal tissues/organs only receive a small fraction of the high central dose of therapy. (totalhealth.co.uk)
  • a promising immunotherapy target in malignant peripheral nerve. (oncotarget.com)
  • In addition, stimulation of the TNF-alpha gene was associated with increased TNF-a protein production in the frontal cortex. (nih.gov)
  • Researchers discovered that loss of the tumor-suppressing TP53 gene allows tumor cells to send genetic messages that transform nerves into cancer-promoting agents. (nih.gov)
  • This gene encodes a protein with similarity to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family. (cancerindex.org)
  • What does this gene/protein do? (cancerindex.org)
  • Human glioma pathogenesis-related protein 1 (GLIPR1) is a p53 target gene with antitumor activity. (cancerindex.org)
  • The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. (nih.gov)
  • Description of the protein which includes the UniProt Function and the NCBI Gene Summary. (nih.gov)
  • The failure of devil immune systems to recognize and destroy the foreign tumor cells may be related to a decline in genetic diversity and may serve as a warning about the vulnerability of species with reduced gene pools. (nih.gov)
  • These represent a gene expression snapshot from the two tissues. (nih.gov)
  • Expression of the pro-opiomelanocortin (POMC) gene, a gene normally expressed in the pituitary gland, also shows elevated expression in the tumor. (nih.gov)
  • For example, searching each of these databases with the Tasmanian devil POMC-like transcript ( XM_003757795 ) shows that reads matching this gene product are much more abundant in the facial tumor than in the testis database as shown in the BLAST graphical overview immediately below. (nih.gov)
  • tural chromatin proteins (i.e., histones) regulated changes in gene expression. (nih.gov)
  • What pathways are this gene/protein implicaed in? (cancerindex.org)
  • The NF1 gene is located on chromosome 17q11.2, which encodes for a tumor suppressor protein, neurofibromin, that functions as a negative regulator of Ras/MAPK and PI3K/mTOR signaling pathways. (mdpi.com)
  • The NF2 gene is identified on chromosome 22q12, which encodes for merlin, a tumor suppressor protein related to ezrin-radixin-moesin that modulates the activity of PI3K/AKT, Raf/MEK/ERK, and mTOR signaling pathways. (mdpi.com)
  • Gene expression matrices of cell lines and tissues were analyzed by Mantel's association test. (bilkent.edu.tr)
  • The EWS protein, produced from the EWSR1 gene, also regulates transcription. (medlineplus.gov)
  • The fusion proteins produced from the less common gene translocations have the same function as the EWS/FLI protein. (medlineplus.gov)
  • If this work is successful, it may change how brain metastases are treated and may improve the outcomes of people with certain types of metastatic tumors. (cancer.org)
  • Cutaneous tumors encompass a vast array of malignancies, ranging from neuroendocrine to lymphoid in origin. (medscape.com)
  • A novel promising candidate in this field is the GLP-1 receptor, which was recently shown to be massively overexpressed in gut and lung neuroendocrine tumors-in particular, in insulinomas. (snmjournals.org)
  • The GLP-1 receptor was recently shown to be highly overexpressed in human gut and lung neuroendocrine tumors-particularly, in insulinomas ( 5 ). (snmjournals.org)
  • It is also a marker for cells of the diffuse neuroendocrine system and their tumors. (neuromics.com)
  • these drugs take aim at the unique genetics of each tumor and patient. (curetoday.com)
  • Normally, APP plays a role in nerve function of many tissues and organs throughout the body. (cancer.org)
  • Whilst any tumour may be destroyed by a very high dose of radiation therapy, it has very often been the case, with orthodox radiotherapy, that it has not been possible to deposit the required dose on a tumour without also depositing a dangerously high dose of radiation on the surrounding organs. (totalhealth.co.uk)
  • Primary amyloidosis is a rare disorder in which abnormal proteins build up in tissues and organs. (adam.com)
  • Neurofibromatosis (NF) is a neurocutaneous syndrome characterized by the development of tumors of the central or peripheral nervous system including the brain, spinal cord, organs, skin, and bones. (mdpi.com)
  • A normal result means the bone marrow contains the proper number and types of blood-forming (hematopoietic) cells, fat cells, and connective tissues. (medlineplus.gov)
  • Sarcoma is a rare but deadly form of cancer affecting connective tissues such as fat, muscle, blood vessels, nerve, bone, deep skin and cartilage. (nfcr.org)
  • The antibody does not stain striated muscle such as skeletal and cardiac muscle, endothelium, connective tissue, epithelium or nerve. (biogenex.com)
  • Isoform Long and isoform Short are predominantly expressed in tissue targets of insulin metabolic effects: liver, adipose tissue and skeletal muscle but are also expressed in the peripheral nerve, kidney, pulmonary alveoli, pancreatic acini, placenta vascular endothelium, fibroblasts, monocytes, granulocytes, erythrocytes and skin. (affbiotech.cn)
  • A systematic analysis was undertaken of multiple protein analytes in the serum of well characterised patients with COPD and matched controls using novel protein microarray platform (PMP) technology. (bmj.com)
  • Bone marrow is the soft tissue inside bones that helps form blood cells. (medlineplus.gov)
  • Researchers don't fully understand how melanoma cells travel to and grow in the brain to form new tumors. (cancer.org)
  • Spherical compartments called extracellular vesicles deliver microRNAs to targeted nerve cells, where they can genetically alter cell growth, identity, and other functions. (nih.gov)
  • [ 7 ] In KAs, cells that stain positive with proliferating-cell nuclear antigen immunostaining are distributed only in the outer edges of the tumor, corresponding to the proliferating squamous epithelial cells. (medscape.com)
  • The protein has proapoptotic activities in prostate and bladder cancer cells. (cancerindex.org)
  • It inhibits nuclear translocation of ribosomal protein subunit 3 (Rps3), a novel latexin-binding protein, and sensitizes hematopoietic cells to radiation-induced cell death. (nih.gov)
  • 8. S-100 protein expressing spindle cells in spindle cell lipoma: a diagnostic pitfall. (nih.gov)
  • However, in the past 5 years the num- proteins (i.e., the chromatin) and by the physiological properties and func- ber of studies that suggested a role for the recruitment of specific proteins tional state of individual cells. (nih.gov)
  • We also examined the effects of MEK inhibition on the native tumor stroma and find that PD325901 decreases VEGFα expression in tumor cells with a corresponding decrease in microvessel density. (duke.edu)
  • This role is based primarily on the peptide receptor overexpression on tumor cells, which allows specific receptor-targeted scintigraphic tumor imaging and tumor therapy with radiolabeled peptide analogs ( 1 ). (snmjournals.org)
  • The immune system cannot respond in the usual way to infections , injuries, or tumors in the brain and spinal cord, because the blood-brain barrier prevents immune cells from entering or leaving. (medicalnewstoday.com)
  • If patrolling immune cells see tumor antigens or signs of infection from the brain, the cells know there is a problem. (medicalnewstoday.com)
  • Noncoding RNAs in exosomes supply a method that cells can straightly regulate the expression of protein in target cells. (hindawi.com)
  • They are derived from body cells including tumor cells [ 29 , 30 ]. (hindawi.com)
  • Because the complex of antigen and antibody is colorless, it is necessary to show the binding site of antigen and antibody by means of histochemistry to achieve qualitative, localized or quantitative research on unknown antigens in tissues or cells. (ballyabio.com)
  • Only when there are cross-antigens in the tissue cells, cross-reactions will occur. (ballyabio.com)
  • now the advent of ABC method or SP allows antibodies to be diluted thousands, tens of thousands, or even hundreds of millions of times, and the antibody can still bind to antigens in tissue cells. (ballyabio.com)
  • This technology can accurately locate antigens in tissues and cells through antigen-antibody reaction and color reaction, so that different antigens can be positioned and observed in the same tissue or cell at the same time. (ballyabio.com)
  • With the cancer cells identified , it can guide modalities aimed at destroying diseased tissue while sparing healthy tissue. (nfcr.org)
  • When these proteins don't develop correctly, too many cells can build up in one place and form a tumor. (dana-farber.org)
  • Spirulina is a type of blue-green algae that is rich in protein, vitamins, minerals, and carotenoids, antioxidants that can help protect cells from damage. (krishnaherbals.com)
  • A number of animal and test tube studies suggest that spirulina increases production of antibodies, infection-fighting proteins, and other cells that improve immunity and help ward off infection and chronic illnesses such as cancer. (krishnaherbals.com)
  • The result is a bunch of very active cells that proliferate in the bone marrow, crowding out healthier cells and making a very sticky antibody that gums up sensitive tissues, like nerve sheathes and the retina. (curetoday.com)
  • In this study, we discovered that depleting immune effector cells of the adaptive immune system (CD8+ T cells) does not increase tumor growth or influence survival in the ID8-fLuc model. (baxkyardgardener.com)
  • Leucine-rich repeat neuronal protein-1 suppresses apoptosis of gastric cancer cells through regulation of Fas/FasL. (cancerindex.org)
  • Tissue engineers routinely mix specialized as well as undifferentiated cells from various sources [2] with biologic, synthetic, and even hybrid scaffold biomaterials [3]. (asme.org)
  • We did not obtain normal neuroblasts nor daughter cells capable of becoming part of a nerve. (irbbarcelona.org)
  • cells invaded other tissues and death followed. (irbbarcelona.org)
  • The tumor was cellular, mitotically active and composed of non-collagen forming closely packed spindly cells. (ijpmonline.org)
  • This mutation is acquired during a person's lifetime and is present only in tumor cells. (medlineplus.gov)
  • This dysregulation of transcription leads to uncontrolled growth and division (proliferation) and abnormal maturation and survival of cells, causing tumor development. (medlineplus.gov)
  • Adipocytes are the cells that primarily constitute adipose tissue. (intechopen.com)
  • Besides adipocytes, adipose tissue also includes the stromal vascular fraction (SVF) of cells including fibroblasts, vascular endothelial cells, and a variety of immune cells such as macrophages. (intechopen.com)
  • The National Comprehensive Cancer network has issued guidelines on genetic testing for soft-tissue sarcoma (see Soft-Tissue Sarcoma Guidelines ). (medscape.com)
  • Researchers from two independent research teams have discovered how the mislocalization of a protein, known as TDP-43, alters the genetic instructions for UNC13A, providing a possible therapeutic target that could also have implications in treating amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other forms of dementia. (nih.gov)
  • Centralized tissue repositories, clinical databases, and other resources will greatly facilitate genetic and epidemiological studies. (nih.gov)
  • These tumors are considered to be related because they have similar genetic causes. (medlineplus.gov)
  • Clumps of the abnormal proteins are called amyloid. (adam.com)
  • Therefore, WAT is considered to be one of the tissues that play a critical role in the onset of lifestyle-related diseases, and the reduction of excess WAT and the improvement of abnormal adipokine secretion are important strategies for the prevention and improvement of lifestyle-related diseases. (hindawi.com)
  • The current pathogenetic theories for the development of COPD include an imbalance between the protease and antiprotease system, dysregulation of oxidant-antioxidant activity and chronic airway inflammation, processes that lead to the progressive destruction and abnormal repair of the lung connective tissue matrix. (bmj.com)
  • Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell bodies. (nih.gov)
  • LRRN1 (leucine-rich repeat neuronal protein-1) is a type I transmembrane protein that plays an important role in the process of nerve development and regeneration. (cancerindex.org)
  • Studies suggest a relation between activated UPR pathways and several disease states such as Parkinson, Alzheimer, inflammatory bowel disease, tumor growth, and metabolic syndrome. (bvsalud.org)
  • it is also a dynamic tissue that is actively involved in metabolic reactions and produces humoral factors, such as leptin and adiponectin, which are collectively referred to as adipokines. (hindawi.com)
  • Adipose tissue is a complicated, crucial, and highly active metabolic and endocrine organ. (intechopen.com)
  • 2. Loss of retinoblastoma protein expression in spindle cell/pleomorphic lipomas and cytogenetically related tumors: an immunohistochemical study with diagnostic implications. (nih.gov)
  • The data are next-generation mRNA and microRNA (miRNA) expression profiles of tumor and normal testicular (testis) tissue and are available in the NCBI Sequence Read Archive (SRA) . (nih.gov)
  • NY-ESO-1 expression was exclusive to malignant tumors. (oncotarget.com)
  • 100% of myxoid/round cell LPS demonstrated NY-ESO-1 expression, while only 6% of WD/DD LPS showed protein expression, one of which was WD LPS. (oncotarget.com)
  • Anticipating a major development of GLP-1 receptor targeting in nuclear medicine, our aim was to evaluate in vitro the GLP-1 receptor expression in a large variety of other tumors and to compare it with that in nonneoplastic tissues. (snmjournals.org)
  • One critical prerequisite for successful in vivo targeting is a high receptor expression in tumors, allowing a high tumoral radiotracer accumulation ( 4 , 7 ). (snmjournals.org)
  • Additionally, because there is much evidence that obesity-induced inflammatory changes in WAT, which is caused by dysregulated expression of inflammation-related adipokines involving tumor necrosis factor- α and monocyte chemoattractant protein 1, contribute to the development of insulin resistance, WAT has attracted special attention as an organ that causes diabetes and other lifestyle-related diseases. (hindawi.com)
  • Here, we investigate whether lower levels of oscillatory brain activity relate to lower NLGN3 expression and predict longer progression free survival (PFS) in diffuse glioma patients.METHODS: Twenty-four newly diagnosed patients with diffuse glioma underwent magnetoencephalography and subsequent tumor resection. (amsterdamumc.org)
  • Exercise also led to increased expression of a protein, called heat shock protein-27, which may have contributed to the reductions in cytokine expression. (japractice.co.uk)
  • In the present study, we found that LRRN1 expression is upregulated in GC tissues and that high LRRN1 expression is associated with poor prognosis. (cancerindex.org)
  • Background: SLIT-ROBO families of proteins mediate axon pathfinding and their expression is not solely confined to nervous system. (bilkent.edu.tr)
  • Methods: Expression of SLIT-ROBO family members was quantified by real-time qRT-PCR in 14 HCC cell lines, 8 normal and 35 tumor tissues from the liver. (bilkent.edu.tr)
  • Results: Genewise hierarchical clustering revealed two subgroups with coordinate expression pattern in both the HCC cell lines and tissues: ROBO1, ROBO2, SLIT1 in one cluster, and ROBO4, SLIT2, SLIT3 in the other, respectively. (bilkent.edu.tr)
  • Moreover, SLIT-ROBO expression predicted AFP-dependent subgrouping of HCC cell lines, but not that of liver tissues. (bilkent.edu.tr)
  • In biopsies, MNC infiltrates in decorin rich CP tissue showed a 300-fold upregulation of MCP-1 compared with decorin free peripheral blood, whereas no difference was found in basal MCP-1 expression in PBMC of patients versus donors. (bmj.com)
  • The most significant change was in expression of tumor necrosis factor receptor 1 (TNFR1) in the distal stump of injured BACE1 KO nerves. (johnshopkins.edu)
  • It is suggested that the term is restricted to proteins secreted from adipocytes, excluding signals released only by the other cell types (such as macrophages) in adipose tissue. (cambridge.org)
  • 17. Mammary-type myofibroblastoma of soft tissue: a tumor closely related to spindle cell lipoma. (nih.gov)
  • From the 19 best predictive clusters, 2-3 biomarkers were selected based on their pathophysiological profile (chemoattractants, inflammation, tissue destruction and repair) and the statistical significance of their relationship with clinically important end points was tested. (bmj.com)
  • High-resolution CT imaging of the temporal bone with axial and coronal views can aid in localization of tumor margins and involvement or erosion of adjacent structures. (medscape.com)
  • This review provides theoretical references and evidences for further exploration of exosomes as noncoding RNA carriers to regulate bone tissue recovery through the following aspects: (1) basic characteristics of exosomes, (2) research progress of exosomal noncoding RNA in bone tissue engineering, (3) current status and advantages of engineering exosomes as nanocarriers for noncoding RNA delivery, and (4) problems and application prospects of exosome therapy in the field of orthopedics. (hindawi.com)
  • The process of bone remodeling is to repair bone damage and restore aging bone tissue [ 7 ]. (hindawi.com)
  • Children with hereditary retinoblastoma are at higher risk of developing other tumors, including childhood tumors in the brain , osteosarcoma (a tumor of the bone), soft tissue sarcomas , and melanoma . (dana-farber.org)
  • Biodegradable PCL-PLGA-beta TCP scaffolds for bone tissue engineering. (stevens.edu)
  • There are several types of Ewing sarcoma, including Ewing sarcoma of bone, extraosseous Ewing sarcoma, peripheral primitive neuroectodermal tumor (pPNET), and Askin tumor. (medlineplus.gov)
  • Approximately 87 percent of Ewing sarcomas are Ewing sarcoma of bone, which is a bone tumor that usually occurs in the thigh bones (femurs), pelvis, ribs, or shoulder blades. (medlineplus.gov)
  • Affected individuals usually feel stiffness, pain, swelling, or tenderness of the bone or surrounding tissue. (medlineplus.gov)
  • Ewing sarcoma accounts for about 1.5 percent of all childhood cancers, and it is the second most common type of bone tumor in children (the most common type of bone cancer is called osteosarcoma). (medlineplus.gov)
  • In recent years, obesity caused by the hypertrophy of white adipose tissue (WAT) has steadily increased worldwide, and has become a serious social problem [ 1 ]. (hindawi.com)
  • It is, however, unclear as to the extent to which adipose tissue contributes quantitatively to the elevated circulating levels of these factors in obesity and whether there is a generalised or local state of inflammation. (cambridge.org)
  • The parsimonious view is that the increased production of inflammatory cytokines and acute-phase proteins by adipose tissue in obesity relates primarily to localised events within the expanding fat depots. (cambridge.org)
  • It is suggested that these events reflect hypoxia in parts of the growing adipose tissue mass in advance of angiogenesis, and involve the key controller of the cellular response to hypoxia, the transcription factor hypoxia inducible factor-1. (cambridge.org)
  • Obesity or insulin resistance-induced molecular alterations in adipose tissue can be detected using these techniques. (intechopen.com)
  • Adipose tissue is the primary storage location for excess energy but it may also be defined as an endocrine organ. (intechopen.com)
  • The antibody can be used to identify smooth muscle tumors. (biogenex.com)
  • After immunizing the animal, a specific antibody is obtained, and then the antibody is used to detect the same antigen substance in the tissue or cell. (ballyabio.com)
  • Because prognosis is primarily dependent on the disease stage rather than the histologic tumor type, evaluation of local and distant extent is pivotal in the ultimate management of soft-tissue sarcoma. (medscape.com)
  • These tumors reflect the histologic properties and spectrum of sarcomas found in patients. (duke.edu)
  • We wanted to understand the reciprocal tumor-nerve signals that drive cancer progression," says first author Moran Amit, MD, PhD. "This information could help scientists develop the means to target this crosstalk. (nih.gov)
  • Its spherical, enveloped capsid has a diameter of ≈50 nm and contains single-stranded RNA that encodes the capsid (C), envelope (E), and premembrane (prM) proteins, as well as 7 nonstructural proteins that likely contribute to viral replication. (cdc.gov)
  • This occurs because PGE2 modulates the trafficking of Nav1.8 by binding to G-protein-coupled EP2 receptor, which in turn activates protein kinase A. Protein kinase A phosphorylates Nav1.8 at intracellular sites, resulting in increased sodium ion currents. (wikipedia.org)
  • Nerve-specific transcripts present at high levels in the tumor include myelin protein zero (MPZ), myelin basic protein (MBP), and nerve growth factor receptor (NGFR). (nih.gov)
  • Moreover, recent results from clinical studies performing somatostatin receptor radionuclide therapy of these tumors are very promising ( 3 , 4 ). (snmjournals.org)
  • A new promising candidate for in vivo tumor targeting is the GLP-1 receptor, a member of the glucagon receptor family ( 11 ). (snmjournals.org)
  • The interaction of insulin with the alpha subunit of the insulin receptor activates the protein tyrosine kinase of the beta subunit, which then undergoes an autophosphorylation that increases its tyrosine kinase activity. (affbiotech.cn)
  • Three adapter proteins, IRS1, IRS2 and Shc, become phosphorylated on tyrosine residues following insulin receptor activation. (affbiotech.cn)
  • That was consistent with previous studies suggesting that inflammation and pro-inflammatory cytokines play a role in the development of neuropathic pain in response to nerve injury. (japractice.co.uk)
  • However, since most are neither 'cytokines' nor 'cytokine-like', it is recommended that the term 'adipokine' be universally adopted to describe a protein that is secreted from (and synthesised by) adipocytes. (cambridge.org)
  • This effect was specific for MCP1-other inflammatory cytokines, such as interleukin 1β and tumour necrosis factor α, were not affected. (bmj.com)
  • The most common tumor of the parotid gland is the pleomorphic adenoma , which represents about 60% of all parotid neoplasms, as seen in the table below. (medscape.com)
  • Most tumors (65%) are benign, with hemangiomas being the most common, followed by pleomorphic adenomas. (medscape.com)
  • The LPS TMA included 48 well-differentiated/dedifferentiated (WD/DD) LPS, 13 myxoid/round cell LPS, 3 pleomorphic LPS, 8 lipomas, 1 myelolipoma, and 3 normal adipocytic tissue samples. (oncotarget.com)
  • The diagnosis and treatment of these cutaneous tumors is constantly evolving, and the role of clinicians relies on accurate diagnosis and a thorough understanding of the clinical sequelae. (medscape.com)
  • Successful diagnosis and treatment of patients with salivary gland tumors require a thorough understanding of tumor etiology, biologic behavior of each tumor type, and salivary gland anatomy. (medscape.com)
  • Our specialty programs are led by pediatric clinicians with deep expertise in diagnosis and treatment of rare and complex solid tumors. (dana-farber.org)
  • Therefore, by defining the bony anatomy, CT scanning can add confirmatory or exclusionary evidence of the presence of these tumors. (medscape.com)
  • Nerve biopsy may be performed to identify nerve degeneration, identify inflammatory nerve conditions (neuropathies), or to confirm specific diagnoses. (adam.com)
  • 20. Immunoreactivity for the human hematopoietic progenitor cell antigen (CD34) in lipomatous tumors. (nih.gov)
  • Immunotherapy targeting cancer-testis antigen NY-ESO-1 shows promise for tumors with poor response to chemoradiation. (oncotarget.com)
  • Firstly, a certain chemical substance in the tissue or cell is extracted and used as an antigen or hapten. (ballyabio.com)
  • polymer linkage, such as a ready-to-use two-step method, which is especially suitable for high endogenous biotin content Tissue antigen detection. (ballyabio.com)
  • Recent studies suggest that these nerves play a role in tumor growth and progression. (nih.gov)
  • Its protein product, p53, is a tumor suppressor that acts as a brake on cancer growth. (nih.gov)
  • Therefore, nociceptors are easily sensitised by agents such as bradykinin and nerve growth factor, which are released at the site of tissue injury, ultimately causing changes to ion channel conductance. (wikipedia.org)
  • Evidence suggests that neuropathological alterations in type 1 diabetic spinal cord may occur at the same time as or following peripheral nerve abnormalities. (bvsalud.org)
  • We demonstrated that DPN was associated with perturbations of RAGE-Diaph1 signaling pathway in peripheral nerve accompanied by widespread spinal cord molecular changes. (bvsalud.org)
  • In silico analysis suggests that molecular changes in spinal cord may act synergistically with RAGE-Diaph1 signaling axis in the peripheral nerve. (bvsalud.org)