• response
  • Resolving the spatial and temporal heterogeneity of subclones with cancer driver events may offer insight into therapy response, tumor evolutionary histories and clinical trial design. (biomedcentral.com)
  • Andreas Villunger and colleagues discuss the biology of the PIDDosome multiprotein complex and recent advances that link PIDDosome-dependent CASP2 activation to p53 activation in response to extra centrosomes. (biologists.org)