Tumor cells cell sarcoma yoshida. Medical search. Frequent questions

This is in contrast to other soft tissue sarcomas in which the lung is the most common site of metastasis. (medscape.com)
If a tumor is large, metastasis is more likely to have occurred. (medscape.com)
The tumors were also examined to determine immunophenotype, histological tumor diagnosis, surgical resection, tumor histological component, largest tumor diameter, and lymph node metastasis status. (turkjpath.org)
Gastrointestinal stromal tumors (GISTs) have a significant risk of metastasis, although the degree varies in each case. (spandidos-publications.com)
Ballarini C, Intra M, Ceretti AP, Prestipino F, Bianchi FM, Sparacio F, Berti E, Perrone S and Silva F: Gastrointestinal stromal tumors: A 'benign' tumor with hepatic metastasis after 11 years. (spandidos-publications.com)
Ginori A, Scaramuzzino F, Marsili S and Tripodi S: Late hepatic metastasis from a duodenal gastrointestinal stromal tumor (29 years after surgery): Report of a case and review of the literature. (spandidos-publications.com)
CD44 is an adhesion molecule for extracellular matrix components such as hyaluronic acid and osteopontin [ 7 ], and plays an important role not only in wound healing and cell migration, but also in tumor invasion and metastasis. (biomedcentral.com)
For instance, CD44v6 interacts with c-Met, the receptor of hepatocyte growth factor (HGF), thereby increasing the survival and proliferative ability of tumor cells That is one of the reasons why the expression of the CD44 splice variant CD44v6 is correlated with the metastasis of colon cancer to the liver and a poor clinical prognosis [ 8 ]. (biomedcentral.com)
Fukui T, Fukumoto K, Okasaka T, Kawaguchi K, Nakamura S, Hakiri S, Ozeki N, Hirakawa A, Tateyama H, Yokoi K.Clinical evaluation of a new tumour-node-metastasis staging system for thymic malignancies proposed by the International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee and the International Thymic Malignancy Interest Group. (nagoya-u.ac.jp)
MicroRNAs (miRNAs) play important roles in initiation, development, progression and metastasis of tumors. (niigata-u.ac.jp)
Cutaneous (skin) metastasis occurs when cells from a cancer in the body spread to the skin. (softdevindia.com)
A solitary metastatic liver tumor of prostate cancer is extremely rare because liver metastasis occurs as a part of systemic dissemination of prostate cancer. (springeropen.com)

Occasionally, these types of tumors can be difficult to differentiate. (medscape.com)
This syndrome is most frequently associated with soft tissue sarcoma, osteosarcoma, pre-menopausal breast cancer, brain cancer, and adrenocortical carcinoma, but it can also result in other types of tumors. (biomedcentral.com)
CD44 has been recently identified as one of the cellular surface markers associated with cancer stem cells (CSCs) in several types of tumors. (biomedcentral.com)

Using a comprehensive tissue microarray (TMA) of both benign and malignant tumors in primary, recurrent, and metastatic samples, we examined NY-ESO-1 expression in peripheral nerve sheath tumor (PNST) and adipocytic tumors. (oncotarget.com)
NY-ESO-1 expression was exclusive to malignant tumors. (oncotarget.com)
Despite the understanding that cell cycle regulatory protein dysregulation may be involved in numerous malignant tumors [ 2 ], there is limited data that explores the role of these oncoproteins with survival data in MMMTs. (biomedcentral.com)
Because the clinical symptoms of Ewing sarcoma are nonspecific and because they frequently mimic osteomyelitis or other malignant tumors, such as leukemia, an initial conventional radiographic and/or magnetic resonance imaging (MRI) examination is performed. (medscape.com)

Plain radiography: Radiography of the primary site and of the chest is helpful in determining the presence of calcifications and bone involvement of the primary tumor and to search for metastatic lung lesions. (medscape.com)
Obtain a CT scan of the liver in patients with abdominal or pelvic primary tumors to assess for metastatic spread. (medscape.com)
Here, we report that DUX4 expression is a common feature of metastatic tumors, with ∼10-50% of advanced bladder, breast, kidney, prostate, and skin cancers expressing DUX4 . (elifesciences.org)
Strong NY-ESO-1 expression was observed in myxoid/round cell and dedifferentiated LPS, and MPNST in primary, neoadjuvant, and metastatic settings. (oncotarget.com)
This study expands our understanding of NY-ESO-1 in WD/DD LPS and is the first demonstration of staining in a WD LPS and metastatic/recurrent myxoid/round cell LPS. (oncotarget.com)
All patients had histologically proven metastatic or advanced angiosarcoma, as reviewed by the Pathology Committee of the French Sarcoma Group, and were not amenable to curative-intent surgery. (biomedcentral.com)
These tumors are usually metastatic disease from other primary sites. (e-roj.org)

Macrophages can eliminate the advanced stage of tumors because of their powerful functions, including phagocytosis and the release of numerous proinflammatory cytokines [interleukin (IL) and tumor necrosis factor (TNF)] and cytotoxic and inflammatory molecules [nitric oxide (NO) and reactive oxygen species (ROS)] that contribute to direct and/or indirect antitumor activities ( 7 - 9 ). (spandidos-publications.com)
Enhanced production of interleukin 1 and tumor necrosis factor by peripheral monocytes after lentinan administration in patients with gastric carcinoma. (gmushrooms.com)
TNF (Tumor necrosis factor) is a pleiotropic cytokine that plays an important role in immunity and inflammatory bone destruction. (frontiersin.org)

Once we succeeded in getting the techniques to work, we began to clone different animal tumor virus genes. (nih.gov)
In the present study, we performed a proliferation assay, phagocytosis assay and cell cycle analysis of macrophages and sequenced the transcriptomes of control group macrophages and TMP-A group macrophages using Illumina sequencing technology to identify differentially expressed genes (DEGs) and determine the molecular mechanisms associated with differences in the immunomodulatory activity of TMP-A in macrophages. (spandidos-publications.com)
A total of 1,043 unigenes were identified as DEGs, and approximately 486 genes were upregulated, whereas 557 genes were down-regulated, which might have contributed to the proliferation activity and phagocytosis activity of TMP-A in the RAW264.7 cells in vitro. (spandidos-publications.com)
Driver events in pediatric malignancies can occur through loss of function in tumor suppressor genes or gain of function in proto-oncogenes. (medscape.com)
Tumor suppressor genes encode proteins that normally provide negative control of cell proliferation. (medscape.com)
Proto-oncogenes are genes that function normally in healthy cells to promote growth and proliferation. (medscape.com)
While they are normally regulated by other genes, including tumor suppressor genes, proto-oncogenes can be activated to become oncogenes that are less sensitive to this regulation. (medscape.com)
Transcription factors, proteins that bind to the regulatory sequences of target genes, compose the largest class of oncogenes identified in pediatric tumors. (medscape.com)
Cell survival and apoptotic regulatory proteins such as the Bcl-2 family of genes, PCNA, p16, p21, p27, and cyclin D1 are of vital importance to malignant neoplasms in prolonging cell survival. (biomedcentral.com)
According to some studies, miRNAs are involved in the process of tumour occurrence and development as proto-oncogenes or tumour suppressor genes [ 8 ]. (biomedcentral.com)
Introduction of purified genes into mammalian cells. (org.ua)
Knowledge of alterations in genome structure could also facilitate identification of corresponding oncogenes or tumor suppressor genes associated with the pathogenesis or progression of the disease. (biomedcentral.com)
Some preliminary results in bone tumors suggest that FDG kinetics are modulated by the expression of chemoresistant genes MDR1 and MRP . (medscape.com)
In MS-K-miR-342 tumor-infiltrated macrophages, expression of proangiogenic genes (Vegf-A and Thbs1) and M2-subtype macrophage markers (Cd163, Dectin1 and Ym1) was significantly down-regulated compared with controls. (niigata-u.ac.jp)
All of these studies revealed associations between molecular profiles and biological behavior of different tumors, without a detailed integration of regulated genes and signaling pathways. (biomedcentral.com)

The antitumor properties are generally related to their ability to induce tumor cell apoptosis and activate macrophages ( 4 ). (spandidos-publications.com)
In addition, it can stimulate apoptosis of cells containing damaged DNA. (medscape.com)
It is usually understood that carcinogenesis is a multistep process that involves defects of the genetic pathways including cell proliferation, cell adhesion, cell death and apoptosis [ 2 ]. (biomedcentral.com)
The UPS is the primary selective proteolytic system in mammalian cells, regulating numerous biological processes such as development, gene transcription, signal transduction, metabolism, apoptosis, cell cycle, DNA repair and inflammation (Chen et al. (springer.com)

Consequently, evaluation of 12q13q15 amplification has been applied clinically as it allows for distinguishing WDLPS/DDLPS from benign adipocytic tumors [ 4 , 5 ]. (biomedcentral.com)

Recent studies have reported CD10 expression in myoepithelial cells (MEC) of the breast, supporting its use as a marker to help distinguish invasive breast carcinoma (IC) from ductal carcinoma in situ (DCIS). (bmj.com)
DUX4 expression is significantly associated with immune cell exclusion and decreased objective response to PD-L1 blockade in a large cohort of urothelial carcinoma patients. (elifesciences.org)
This group includes pleomorphic carcinomas (PCs), carcinosarcomas (CSs), and pulmonary blastomas (PBs) with sarcoma and carcinoma components. (turkjpath.org)
On the other hand, the SMARCA4 alteration rate is 2.7-10% in common carcinomas of the lung such as adenocarcinoma, small cell carcinoma, squamous cell carcinoma, non-small cell carcinoma, and large cell neuroendocrine carcinoma 6 . (turkjpath.org)
The cases identified were re-evaluated according to the sarcomatoid carcinoma criteria of the World Health Organization Lung Tumor Classification. (turkjpath.org)
Nakamura S, Kawaguchi K, Fukui T, Fukumoto K, Okasaka T, Yokoi K. The development of large-cell carcinoma in the wall of a giant bulla complicated by Hemorrhage. (nagoya-u.ac.jp)
Fukui T, Taniguchi T, Kawaguchi K, Fukumoto K, Nakamura S, Sakao Y, Yokoi K. Comparisons of the clinicopathological features and survival outcomes between lung cancer patients with adenocarcinoma and squamous cell carcinoma. (nagoya-u.ac.jp)

This tumor can co-express epithelial, neuronal, and mesenchymal markers. (sarcomahelp.org)
Tumor cells co-express epithelial, mesenchymal and neuronal markers and are thought to originate from a mesothelial or submesothelial progenitor cell with the potential to undergo multilineage differentiation. (sarcomahelp.org)
Focal background staining of stromal myofibroblasts was seen with both CD10 and SMMHC, but CD10 showed a higher rate of non-specific staining of epithelial cells. (bmj.com)
Myoepithelial cells (MEC) are contractile elements found in salivary, sweat, and mammary glands that show a combined smooth muscle and epithelial phenotype. (bmj.com)
1 In the normal breast, the ductal and acinar units are lined by two cell layers: the inner layer of epithelial cells lining the lumen and an outer layer of contractile MEC. (bmj.com)
Given the mixed epithelial and smooth muscle phenotype of MEC, and the need to distinguish the MEC layer from the epithelial cell layer, most of the immunohistochemical markers used are directed against smooth muscle related antigens. (bmj.com)
Botryoid: The cambium layer is characteristic, containing a condensation of loose tumor cells below an epithelial surface. (medscape.com)
These tumors typically exhibit high epithelial-mesenchymal transformation abilities. (turkjpath.org)
Notably, CD44 variants (CD44v) are exclusively expressed in epithelial-type cells, whereas the CD44 standard isoform (CD44s) is expressed in both epithelial and mesenchymal cells [ 9 ]. (biomedcentral.com)
Primary hepatic angiosarcoma is a non-epithelial malignancy derived from sinusoidal endothelial cells, accounting for approximately 1.8% of primary hepatic malignancies. (springeropen.com)

Franchi et al, using immunohistochemistry and electron microscopy, found no significant differences among these tumors or between these surface variants and conventional osteosarcoma. (medscape.com)
In this case, point mutations of GNAS were found in the FD and osteosarcoma but not in the adjacent normal tissues, suggesting that osteosarcoma was derived from the spindle cells of FD. (metasystems-international.com)
This is the first report to clearly show that osteosarcoma is derived from the spindle cells in fibrous dysplasia (FD). (metasystems-international.com)
The 2 most common malignant bone tumors in children are osteosarcoma and Ewing sarcoma. (medscape.com)

It has been reported to be less than 1% of brain biopsy that was about 3 out of 25,000 primary brain tumors [ 2 ]. (e-roj.org)

Approximately 1%-2% of solid tumors are soft-tissue sarcomas, and leiomyosarcomas comprise roughly 2%-9% of these sarcomas. (medscape.com)
Activation of proto-oncogenes is a common theme in childhood leukemias and solid tumors. (medscape.com)

Using mouse Sarcoma‐180 (S‐180) tumors, the authors examined the effects of 5‐fluoroura‐cil (5‐FU) and a combined oral preparation of l‐(Gtetra‐hydrofuryl)‐5‐fluorouracil (FT) and uracil in a molar ratio of 1:4 (UFT), in combination with HT. (elsevierpure.com)
Sing, inhibited mouse sarcoma 180 and displayed low toxicity compared with chemical antitumor drugs ( 10 ), a number of polysaccharides with immunostimulatory and antitumor activities from species such as Coriolus versicolor , Agaricus blazei and Panax ginseng have been reported ( 11 - 13 ). (spandidos-publications.com)

It can be difficult to differentiate between Ewing sarcoma and osteomyelitis on CT and ragiographs. (medscape.com)

Periosteal chondromas are rare, constituting 2.2% of benign tumors and 0.5% of all tumors in the Mayo Clinic series. (medscape.com)

It is active in the pathogenetic pathway of complex, undifferentiated, and aggressive pediatric tumors with a rhabdoid phenotype, malignant rhabdoid tumors of the kidney, extrarenal soft tissue tumors, and visceral organ tumors 2 - 4 . (turkjpath.org)

MicroRNA-342 inhibits tumor growth via targeting chemokine CXCL12 involved in macrophages recruitment/activation. (niigata-u.ac.jp)

Esophageal carcinosarcoma (ECS) is a rare biphasic tumor and a type of eso phageal malignancy, which presents as protruding or elevated lesions. (wjgnet.com)

RB1 encodes the protein pRB and was the first tumor suppressor gene to be molecularly defined. (medscape.com)
Li-Fraumeni syndrome (LFS) is a hereditary cancer predisposition syndrome that is commonly associated with a germline mutation in the tumor suppressor gene p53 . (biomedcentral.com)
Kobayashi D, Araki N. Data for quantitative proteome analyses of tumor suppressor gene NF1-deficient PC12 cells during NGF induced neural differentiation using iTRAQ. (tgbaraki.com)

Systemic manifestations of localized, nonmetastatic EMC have never been described in the pediatric population, yet our patient's anemia and poor weight gain resolved after successful surgical resection of the tumor, suggesting that localized EMC can present with systemic manifestations. (cancer-genetics.org)

The present study investigates the role of a peritumoral stromal reaction in IL-12-induced T-cell migration. (aacrjournals.org)
Stromal tissue containing neovascular blood vessels developed at the peritumoral area of the former two IL-12-responsive tumors but not at the peritumoral area of the latter two IL-12-unresponsive tumors. (aacrjournals.org)
In the past, GI stromal tumors ( GISTs ) were misdiagnosed as leiomyosarcomas. (medscape.com)
Colonic mucosa with gastrointestinal stromal tumor (GIST) involving the adjacent submucosa (hematoxylin and eosin [H&E] stain, medium power). (medscape.com)
Miettinen M, Sarlomo-Rikala M and Lasota J: Gastrointestinal stromal tumors: Recent advances in understanding of their biology. (spandidos-publications.com)
Furukawa M, Izumi S, Asano H, Tokumo M, Mano S and Shiota K: Late umbilical port-site recurrence of a gastrointestinal stromal tumor with an acquired PDGFRα mutation after laparoscopic resection: Report of a case. (spandidos-publications.com)

However, the differential diagnosis between WDLPS and DDLPS is much more challenging, because about 10% of DDLPS are the recurrences of WDLPS as a non-lipogenic sarcoma of variable histological grade. (biomedcentral.com)

Malignant peripheral nerve sheath tumors (MPNSTs) and liposarcomas (LPS) are chemoresistant and have few effective treatment options. (oncotarget.com)
Rarity and heterogeneity of liposarcomas (LPS) make their diagnosis difficult even for sarcoma-experts pathologists. (biomedcentral.com)
Liposarcomas (LPS), the most common soft tissue sarcomas accounting for less than 1% of all human cancer cases, display remarkable clinical and pathological heterogeneity. (biomedcentral.com)
Morphologically, liposarcomas are divided into four main subtypes: well-differentiated (WDLPS), dedifferentiated (DDLPS), myxoid/round cell (MLPS/MRLPS) and pleomorphic liposarcomas (PLPS). (biomedcentral.com)

Rhabdomyosarcoma cells tend to have variable differentiation along the myogenesis pathway and may appear as strap cells or myotubes that sometimes contain muscle cross-striations. (medscape.com)
A KEGG pathway enrichment analysis showed that the MAPK and NF-κB signaling pathways are significantly enriched for DEGs between the two cell groups. (spandidos-publications.com)
It specifically negatively regulates the PI3K-AKT signaling pathway to induce cell cycle arrest. (medscape.com)
Our study supports that a) cell cycle and apoptotic regulatory protein dysregulation is an important pathway for tumorigenesis and b) p53 is an important immunoprognostic marker in MMMT of the uterus. (biomedcentral.com)
Next, a method to score deregulation of KEGG pathway maps in different tumor entities was established, which was then used to convert hundreds of gene expression profiles into corresponding tumor-specific pathway activity profiles. (biomedcentral.com)
The functional cancer map provides a systematic view on molecular similarities across different cancers by comparing tumors on the level of pathway activity. (biomedcentral.com)

Immune checkpoint inhibition (ICI) therapy utilizes immunomodulatory monoclonal antibodies to stimulate patient anti-tumor immune responses. (elifesciences.org)
Tumor cell-intrinsic interferon-gamma (IFN-γ) signaling is particularly important in anti-tumor immunity. (elifesciences.org)
1981. Immunological characteristics of anti-tumor polysaccharides lentinan and its analogues, as immune adjuvants. (gmushrooms.com)

The intracellular metabolism of 5‐FU and FT in whole homogenates of S‐180 cells, human tumor cell lines (SC‐2 and Lu‐99), and five fresh human tumor tissues also was investigated. (elsevierpure.com)
Complete available human tumor data of the Stanford Microarray Database was downloaded and filtered for relevance, adequacy and reliability. (biomedcentral.com)

The results showed that TMP-A exhibits strong proliferation activity and phagocytosis activity in RAW264.7 cells in vitro and could also promote the proliferation of macrophage cells by abolishing cell-cycle arrest in the G0/G1 phase and promoting the cell cycle in the G2/M phase, which may induce cell division. (spandidos-publications.com)
At a fundamental level, cancer is caused by an accumulation of genetic changes that result in unregulated cell growth and proliferation. (medscape.com)
PTEN encodes a protein kinase of the same name and functions as a tumor suppressor through regulation of cell proliferation. (medscape.com)
Over-expression of miR-342 in MS-K cells inhibited cell proliferation, colony formation, reduced frequency of S phase population in vitro and suppressed tumor growth in vivo. (niigata-u.ac.jp)
Restored Cxcl12 expression in MS-K-miR-342 cells could rescue cell proliferation in vitro. (niigata-u.ac.jp)

Logically, resection, which is the only hope for a cure, appears to be more difficult with larger tumors. (medscape.com)
In the present study, we searched for patients diagnosed with PCs, CSs, or PBs who underwent anatomic lung tumor resection between January 1, 2010, and December 31, 2019. (turkjpath.org)
The present report describes a case of late recurrence of GIST that was diagnosed 30 years after the primary tumor resection. (spandidos-publications.com)
10 years after primary tumor resection. (spandidos-publications.com)
Kato T, Iwano S, Taniguchi T, Kawaguchi K, Fukui T, Ishiguro F, Fukumoto K, Nakamura S, Hirakawa A, Yokoi K. The contact length between the tumor contour and the lung on computed tomography is a risk factor for pleural recurrence after complete resection of thymoma. (nagoya-u.ac.jp)
Pleural lavage cytology before and after lung resection in non-small cell lung cancer patients. (softdevindia.com)

Leiomyosarcoma (LMS) as a primary intracranial tumor arise from blood vessels or dura matter mesenchymal cells. (e-roj.org)

Comprehensive analyses of genotype-phenotype correlations have led to a better understanding of tumors that are associated with germline p53 mutations [ 6 ]. (biomedcentral.com)
Loss-of-functional mutations in the p53 gene promote tumor development. (biomedcentral.com)

Interleukin (IL) 12 has been shown to elicit tumor regression when this cytokine induces the migration of T cells to tumor sites. (aacrjournals.org)

Rhabdomyosarcoma cells may demonstrate positive immunohistochemical results for muscle-specific markers, such as myoglobin, actin, and desmin. (medscape.com)
The loss of SMARCA4 and SMARCA2 expression in the tumors was evaluated using immunohistochemical methods. (turkjpath.org)

Desmoplastic small round cell tumor (DSRCT) is an aggressive malignant neoplasm that occurs in adolescents and young adults. (sarcomahelp.org)
If a low-grade tumor recurs, it often does so with a new, more aggressive grade of histology. (medscape.com)
Sarcomatoid carcinomas of the lung are a group of aggressive tumors. (turkjpath.org)
These are highly aggressive tumors. (turkjpath.org)
These results suggest immunotherapy targeting NY-ESO-1 may benefit patients with aggressive tumors resistant to conventional therapy. (oncotarget.com)
Dedifferentiated chondrosarcoma is an aggressive mesenchymal tumor of the bone, and novel therapies are needed to improve its clinical outcomes. (cancer-genetics.org)

[ 4 ] An association exists between Ewing sarcoma and primitive peripheral neuroectodermal tumor (PNET). (medscape.com)

From the animal tumor viruses, we obtained oncogenes and used the oncogenes as probes. (nih.gov)

Pathological examination using archival pathological samples revealed that the previously excised tumor was GIST because the tumor cells showed positive immunoreactivity for KIT and DOG1. (spandidos-publications.com)
Clinicians should keep in mind that GISTs were formerly confused with non‑GIST tumors and that there is a risk of relapse 10 years or later after curative surgery. (spandidos-publications.com)

Given their great potential to become biomarkers for the prognosis, diagnosis, and treatment of diseases in clinical practice, it is of great significance to analyse the relationship between miRNAs and the clinicopathological characteristics of tumour patients [ 9 ]. (biomedcentral.com)
Patient-derived cell lines are essential tools for elucidating disease mechanisms associated with poor prognosis and for developing therapies. (cancer-genetics.org)
The prognosis of this tumor is poor and the survival range from 3 weeks [ 14 ] to 44 months [ 15 ] in the literature. (e-roj.org)

Sharma et al concluded that 18 F-FDG PET/CT demonstrated high accuracy in diagnosing the recurrence of primary skeletal Ewing sarcoma. (medscape.com)

The LPS TMA included 48 well-differentiated/dedifferentiated (WD/DD) LPS, 13 myxoid/round cell LPS, 3 pleomorphic LPS, 8 lipomas, 1 myelolipoma, and 3 normal adipocytic tissue samples. (oncotarget.com)

CSCs are defined as the small population of cancer cells with multi-lineage differentiation potential. (biomedcentral.com)
MS-K-CCL11-conditioned medium (CM) and recombinant CCL11 induced macrophage and eosinophil differentiation from bone marrow cells. (niigata-u.ac.jp)
The pathogenesis of cutaneous metastases from lung cancer is suggested to be by lymphovascular invasion, with poor differentiation and upper lobe tumors increasing the risk. (softdevindia.com)

However, in most cases, it is impossible to determine whether the tumor arose from within the periosteum or from other juxtacortical connective tissues, with secondary involvement of the periosteum. (medscape.com)
Malignancy can be potentially derived from dysplastic cells in the area of the FD or cells in the adjacent normal tissues. (metasystems-international.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Lee et al examined FET, FLT, and FDG to differentiate tumor from inflammation and found that FET selectively localized in tumor tissues but not in inflammation. (medscape.com)
A total of 649 tumor samples from more than 1400 experiments and 58 different tissues were analyzed. (biomedcentral.com)

In many centers, the use of RT-PCR to screen for a panel of translocations associated with soft tissue sarcomas is becoming a routine adjunct to morphologic analysis to help ascertain the diagnosis. (medscape.com)
Although CNAs varied widely, the subtypes of tumors have characteristic genomic profiles that could facilitate the differential diagnosis of LPS subtypes, especially between WDLPS and DDLPS. (biomedcentral.com)
No single morphologic or functional imaging method provides findings for a specific diagnosis of Ewing sarcoma, but the results do contribute to tumor staging. (medscape.com)

DUX4 expression is a significant predictor of survival even after accounting for tumor mutational burden and other molecular and clinical features in this cohort, with DUX4 expression associated with a median reduction in survival of over one year. (elifesciences.org)

These surface lesions may arise from any of the mesenchymal elements present along the bone surface or from the pluripotent cells found within the periosteum. (medscape.com)
In contrast, TNF often acts on cell types other than osteoclasts, or synergically with RANKL to indirectly promote osteoclastogenesis and bone resorption. (frontiersin.org)
Normal bone remodeling requires a delicate balance between the activities of major bone cell types: bone-resorbing osteoclasts and bone-forming osteoblasts, as well as osteocytes. (frontiersin.org)
Osteoclasts are bone cells derived from monocyte/macrophage lineage and are exclusively responsible for bone resorption, which contributes to skeletal development, bone homeostasis, and remodeling. (frontiersin.org)
Ewing sarcoma is a highly malignant primary bone tumor that is derived from red bone marrow. (medscape.com)
Ewing sarcoma accounts for approximately 5% of biopsy-analyzed bone tumors and approximately 33% of primary bone tumors. (medscape.com)
[ 2 ] This disease is the second most common malignant bone tumor in young patients, and it is the most lethal bone tumor. (medscape.com)
This image demonstrates the tumor is primarily confined to the bone, with a small periosteal fraction. (medscape.com)

Ultrasonography: Obtain sonograms of the liver in patients with abdominal or pelvic tumors. (medscape.com)
Undifferentiated embryonal sarcoma of the liver (UESL) is a rare malignant mesenchymal tumor that usually occurs in children and is rarely diagnosed in adults. (springeropen.com)

GISTs, however, have been shown to lack characteristics of smooth muscle tumors on histologic examination. (medscape.com)
Radiologic characteristics of Ewing sarcoma are seen in the images below. (medscape.com)

Angiosarcomas account for approximately 1% of adult soft-tissue sarcomas, the latter of which account for 1-2% of adult malignancies. (biomedcentral.com)
Somatic copy number aberrations (CNAs) occur commonly in human cancer and evaluation of their characteristic patterns may be used as a diagnostic tool, especially in soft tissue sarcomas [ 3 ]. (biomedcentral.com)

Here, we found that miR-342 was expressed significantly less in a murine MS-K tumor cell line that showed riched blood vessels. (niigata-u.ac.jp)
Moreover, increasing miR-342 impeded blood vessels formation and accumulation of macrophages (CD11b+ ) in tumors. (niigata-u.ac.jp)

Loss of the SMARCA complex may be caused by the heterogeneous morphological profile of sarcomatoid carcinomas, independent of tumor histopathological parameters. (turkjpath.org)
The relationship of protein loss with tumor components and histopathological prognostic factors was examined. (turkjpath.org)

These tumors can mimic meningioma on imaging. (e-roj.org)

Primary gastrointestinal (GI) sarcomas in general are a very rare entity, accounting for 1%-2% of GI malignancies. (medscape.com)

Consistently, multiple pathways commonly associated with tumor progression were revealed as common features in the majority of the tumors. (biomedcentral.com)

In the nucleus of cell, the acetylation and de-acetylation of histone is in a dynamic balance, which precisely regulates gene transcription and expression [ 1 , 2 ]. (biomedcentral.com)
The tumor also contained a novel t(2;22)(q34;q12) translocation involving the EWSR1 gene, which is consistent with additional reports suggesting that a growing list of translocations can drive formation of, and potential new management strategies for, EMC. (cancer-genetics.org)
[15] Chalepakis G, Arnemann J, Slater E, Br?ller HJ, Gross B, Beato M. Differential gene activation by glucocorticoids and progestins through the hormone regulatory element of mouse mammary tumor virus. (org.ua)
[18] Grosschedl R, Weaver D, Baltimore D, Costantini F. Introduction of a mu immunoglobulin gene into the mouse germ line: specific expression in lymphoid cells and synthesis of functional antibody. (org.ua)
IL-6 is a gene that encodes a cytokine that plays a role in inflammation and the maturation of B cells. (thermofisher.com)

Primary intracranial mesenchymal neoplasms are rare tumors. (e-roj.org)

Liposarcoma is the single most common soft tissue sarcoma. (springeropen.com)

The embryonic transcription factor DUX4 was recently characterized as a suppressor of interferon-γ signaling and antigen presentation that is aberrantly expressed in a small subset of primary tumors. (elifesciences.org)
Immunotherapy targeting cancer-testis antigen NY-ESO-1 shows promise for tumors with poor response to chemoradiation. (oncotarget.com)

The original cell of malignancy in FD is unclear. (metasystems-international.com)

Abdominal contrast‑enhanced computed tomography revealed an 11.7‑cm heterogenous tumor in the retroperitoneum adjacent to the third portion of the duodenum. (spandidos-publications.com)

[ 1 ] Periosteal chondrosarcoma is more rare than its benign counterpart, periosteal chondroma, with an incidence of 0.15% of all tumors in the Mayo Clinic series. (medscape.com)
Extraskeletal myxoid chondrosarcoma (EMC), a soft-tissue sarcoma with unique clinicopathologic features and characteristic chromosomal translocations, is extremely rare in the pediatric population. (cancer-genetics.org)
Establishment and characterization of a novel dedifferentiated chondrosarcoma cell line, NCC-dCS1-C1. (cancer-genetics.org)
We established a novel patient-derived dedifferentiated chondrosarcoma cell line, NCC-dCS1-C1. (cancer-genetics.org)

When cytogenetic testing is unavailable (eg, culture failure) or when its results are uninformative, order a RT-PCR reaction to assess for the characteristic translocations associated with alveolar rhabdomyosarcoma (ARMS) and other small, round blue-cell tumors of childhood. (medscape.com)

The aim of our study was to evaluate survival outcomes in malignant mixed Mullerian tumors (MMMT) of the uterus with respect to the role of cell cycle and apoptotic regulatory proteins in the carcinomatous and sarcomatous components. (biomedcentral.com)
The aim of this study is to evaluate the role of cell cycle and apoptotic regulatory proteins in the carcinomatous and sarcomatous components of uterine MMMT in relation to clinico-pathological data including survival outcomes. (biomedcentral.com)
Thus, maintenance of protein homeostasis (proteostasis) is essential for cell function and survival (Fig. 1 ). (springer.com)

This antibody is produced by injecting Rat IgG secreting hybridoma cells into the peritoneum of mice. (thermofisher.com)
The MS-K-CCL11 cells did not form tumors in mice. (niigata-u.ac.jp)
Administration of an antagonist of CCR3, a CCL11 receptor, to NFSA tumor-bearing mice restored the blood vessel formation and blocked the eosinophil infiltration into the NFSA tumors. (niigata-u.ac.jp)

citation needed] Research on Yoshida Sarcoma, a strain of tumor cells, was also conducted at this institute in the 1950s. (wikipedia.org)

Alveolar: Cells line up along membranes that may be imperceptibly thin or that may be obvious collagen bands resembling the lung alveoli. (medscape.com)
Koizumi A, Tamura Y, Yoshida R, Mori C, Ono Y , Tanino M, Mizukami Y , Sasaki T. Two Cases of SMARCA4-Deficient Non-small Cell Lung Cancer (NSCLC) with Improved Performance Status (PS) after Treatment with Immune Checkpoint Inhibitors (ICIs). (or.jp)
Mori S, Usami N, Fukumoto K, Mizuno T, Kuroda H, Sakakura N, Yokoi K, Sakao Y. The Significance of the Prognostic Nutritional Index in Patients with Completely Resected Non-Small Cell Lung Cancer. (nagoya-u.ac.jp)
Ozeki N, Kawaguchi K, Fukui T, Fukumoto K, Nakamura S, Okasaka T, Yokoi K. Which variables should be considered in patients with stage II and III non-small cell lung cancer after neoadjuvant therapy? (nagoya-u.ac.jp)
Fukumoto K, Taniguchi T, Usami N, Kawaguchi K, Fukui T, Ishiguro F, Nakamura S, Yokoi K. The ABO blood group is an independent prognostic factor in patients with resected non-small cell lung cancer. (nagoya-u.ac.jp)
Looks like the skin cancer that was removed a few years back (and we were told that they had gotten it all) has returned and formed a tumor about the size of a quarter in her right lung. (softdevindia.com)

Concise grouping of tumor types in cancer maps according to their molecular profile may further be helpful for the development of new therapeutic modalities or open new avenues for already established therapies. (biomedcentral.com)
Utilization of these functional associations to place global transcriptome data in a biological context might significantly improve the limited knowledge about common molecular changes across different tumor types. (biomedcentral.com)

This study, published in 1932 by Takaoki Sasaki and Tomizo Yoshida, was the first scientific report in the world on a successful method for induction of cancer in animal organs by feeding chemicals. (wikipedia.org)
The use of chemotherapy to treat cancer began at the start of the 20th century with attempts to narrow the universe of chemicals that might affect the disease by developing methods to screen chemicals using transplantable tumors in rodents. (aacrjournals.org)
Loss of p53 results in increased expression of CD44, a cancer stem cell (CSC) marker, which is involved in the scavenging of reactive oxygen species (ROS). (biomedcentral.com)
This case demonstrates the ectopic up-regulation of CD44v8-10 in a biopsy sample obtained after cytotoxic chemotherapy, which confers high levels of oxidative stress on cancer cells. (biomedcentral.com)
田中伸哉、鈴鹿淳、王磊、津田真寿美、龔剣萍、高阪真路、間野博行、「ハープ現象の発見：DNゲルでがん幹細胞を創り出す（Rapid reprogramming of tumour cells into cancer stem cells on double-network hydrogel）」、実験医 (hokudai.ac.jp)
Cancer cells are characterized by massive dysegulation of physiological cell functions with considerable disruption of transcriptional regulation. (biomedcentral.com)
We provide a comprehensive, easy-to-interpret functional cancer map that characterizes tumor types with respect to their biological and functional behavior. (biomedcentral.com)

Anatomy3

Organisms2

Diseases34

Chemicals and Drugs5

Analytical, Diagnostic and Therapeutic Techniques and Equipment8

Phenomena and Processes5

Disciplines and Occupations1

Information Science2

Metastasis12

Types of tumors3

Malignant tumors4

Metastatic7

Necrosis factor3

Genes15

Apoptosis4

Adipocytic tumors1

Carcinoma7

Epithelial10

Osteosarcoma4

Brain tumors1

Solid tumors2

Mouse sarcoma2

Difficult to differentiate1

Benign tumors1

Pediatric tumors1

Inhibits tumor growth1

Biphasic tumor1

Suppressor gene3

Surgical resection1

Stromal6

Histological1

Liposarcomas4

Pathway6

Anti-tumor3

Human tumor2

Proliferation5

Resection6

Mesenchymal cells1

Mutations2

Interleukin1

Immunohistochemical2

Aggressive6

Peripheral1

Oncogenes1

GIST2

Prognosis3

Recurrence1

Pleomorphic1

Differentiation3

Tissues5

Diagnosis3

Clinical1

Bone8

Liver2

Characteristics2

Soft tissue sarcomas2

Blood vessels2

Histopathological2

Mimic1

Gastrointestinal1

Progression1

Gene5

Neoplasms1

Liposarcoma1

Antigen2

Malignancy1

Heterogenous1

Chondrosarcoma4

Characteristic1

Survival3

Mice3

Strain1

Lung6

Molecular2

Cancer7