• The microenvironment of a tumor is different compared to normal healthy tissues in the body. (wikipedia.org)
  • As a result, targeting the acidic microenvironment of tumors has emerged as a promising strategy for cancer therapy. (wikipedia.org)
  • the tumor microenvironment enhancing drug bioavailability and effectiveness due to the practical differences between normal and tumor cells. (exposed-skin-care.net)
  • Herein, we report near-infrared light and tumor microenvironment (TME), dual responsive as well as size-switchable nanocapsules. (nature.com)
  • Scaffolds for tissue regeneration must present a viable microenvironment for the living cells to adhere, proliferate, and exhibit the necessary tissue function. (asme.org)
  • The tumor and its microenvironment may not seem very comfortable by our standards: immune-suppressed, sometimes anoxic or even necrotic. (vitares.org)
  • However, increasing data has indicated that the clinical potential of most immunotherapies is usually hampered by immunosuppressive status of the tumor microenvironment (TME) [ 7 ]. (thno.org)
  • nHA particles functionalized with DOX get engulfed in the lysosome of osteosarcoma cells where the acidic microenvironment causes a disruption of the binding between DOX and HA. (lu.se)
  • pH-responsive tumor-targeted drug delivery is a specialized form of targeted drug delivery that utilizes nanoparticles to deliver therapeutic drugs directly to cancerous tumor tissue while minimizing its interaction with healthy tissue. (wikipedia.org)
  • These polymer drug carriers carry the therapeutic drugs to allow for targeted drug delivery. (wikipedia.org)
  • Moreover, common targeted therapeutic drug formulations have weak stability in malignant tumor leukemia, and their application effects are limited. (frontiersin.org)
  • For example cellular focusing on of antibodies or specific ligands is based on the capability of the focusing on providers to selectively bind to the cell surface to result in receptor-mediated endocytosis.3 5 Thus the drug delivery system along with the therapeutic agent would be delivered to the interior of a given cell type. (exposed-skin-care.net)
  • In vivo experiments demonstrate that these nanocapsules can target to tumor sites through fluorescence/magnetic resonance imaging and offer remarkable therapeutic results. (nature.com)
  • However, despite immense medical progress, the successful delivery of therapeutic bacteria to tumors remains challenging. (e-flux.com)
  • Prodrug technologies aimed at delivering nucleoside monophosphates into cells (protides) have proved to be effective in improving the therapeutic potential of antiviral and anticancer nucleosides. (birmingham.ac.uk)
  • Using established molecular biology techniques, Rubius's scientists can engineer progenitor cells taken from human bone marrow and grow blood cells that produce specific therapeutic proteins on their surface or inside the cell. (technologyreview.com)
  • The cells can get anywhere in the body through the bloodstream and can protect the therapeutic agent from the immune system, says Kahvejian. (technologyreview.com)
  • Therapeutic efficacy of drugs is often diminished due to their low bioavailability, insolubility, toxicity and their decomposition under biological conditions. (europa.eu)
  • pH Sensitive Drug Delivery Systems (PSDDS) are gaining importance as these systems deliver the drug at specific time as per the pathophysiological need of the disease, resulting in improved patient therapeutic efficacy and compliance. (scialert.net)
  • By providing native extracellular vesicles from mesenchymal stem cells and targeting extracellular vesicles Evercyte will make a significant contribution to the development of new therapeutic approaches. (biospace.com)
  • Valproic acid is a commonly used therapeutic drug for the treatment of epilepsy and bipolar disorder. (asme.org)
  • The ability to measure the absorbed dose (AD) delivered to each tumor or critical structure following administration of therapeutic activity. (voximetry.com)
  • In recent years, tumor-targeted therapy has been appearing as a promising therapeutic choice for cancer treatment. (hindawi.com)
  • The emergence of multifunctional nanomaterials can expectedly endow these therapeutic cargoes with high solubility, favorable pharmacokinetic distribution, cell-specific delivery, and controlled release. (thno.org)
  • Immunotherapy is currently considered as a promising next-generation therapeutic strategy for various cancers thanks to its ability to modulate cell-specific immune responses toward tumors [ 1 ], which has gradually remodeled the landscape of clinical anticancer modality [ 2 ]. (thno.org)
  • In advanced cancer therapy, the combinational therapeutic effect of photothermal therapy (PTT) using near-infrared (NIR) light-responsive nanoparticles (NPs) and anti-cancer drug delivery-mediated chemotherapy has been widely applied. (oncotarget.com)
  • Diagnostic and therapeutic uses for cysteine engineered antibody drug compounds and compositions are disclosed. (justia.com)
  • 2017 ). Studies have shown that the conjugation of antitumor drugs with a PNC reduced the toxicity and improved the pharmacokinetic parameters of the drugs and increased their therapeutic efficacy (Heffeter et al. (biomedcentral.com)
  • Investigators at the Department of Clinical Genetics have a strong track record in identifying novel cell surface markers on leukemia stem cells and were the first to demonstrate the potential therapeutic use of recombinant antibodies directed against the marker IL1RAP (interleukin-1 receptor accessory protein) on cancer stem cells in chronic myeloid leukemia (CML) and acute myeloid leukemia (AML). (lu.se)
  • The strategy used to identify new therapeutic markers on leukemia stem cells will also be explored in other tumor types studied within the MAD for Cancer Program. (lu.se)
  • The complex compromises a drug delivery unit made up of a carrier molecule made up of organic nanomaterials, inorganic nanomaterials, composite nanomaterials, and anti-tumor drugs. (wikipedia.org)
  • The loading of anti-tumor drugs into pH-responsive polymer nanomaterials can be classified into three categories: chemical bonding, intermolecular force, and physical encapsulation. (wikipedia.org)
  • Therefore, based on the characteristics of black phosphorus two-dimensional nanomedicine, experimental designs were conducted on its nanosheet preparation, polyethylene glycol modification, and anti-tumor drug loading. (frontiersin.org)
  • and anti-tumor assays. (ajol.info)
  • Bacteria "steal" nutrients from cancer cells, enhance the host anti-tumor immunity and form biofilms that cause metastasis disruption. (vitares.org)
  • These drug delivery systems have been created to react to the pH environment of diseased or cancerous tissues, triggering structural and chemical changes within the drug delivery system. (wikipedia.org)
  • We found that cytoplasmic linker protein 170 (CLIP170) was overexpressed in HNSCC tissues and cells compared to normal controls. (nih.gov)
  • On the contrary, small size NPs with a diameter of 4-20 nm easily penetrate into deep tumor tissues, but they are more prone to rapid clearance and insufficient drug retention. (nature.com)
  • Besides customer-tailored cell line development as a one-stop shop, Evercyte is steadily expanding its catalog of readily available cell lines for the production of extracellular vesicles from mesenchymal stem cells using different tissues including Wharton's Jelly, adipose tissue, bone marrow, and placenta. (biospace.com)
  • Among these, Raman spectroscopy has attracted increasing attention as a highly sensitive molecular imaging technique for studying complex biological systems, including cells, tissues, and various biological materials [ 4 ]. (medsci.org)
  • This technique allows non-destructive, label-free spectral imaging and analysis of cells, tissues, and nanoparticles [ 5 - 7 ]. (medsci.org)
  • These cells revolutionize the ability to interface biological tissues since they selectively bind to synthetic/ natural drug moieties and deliver drugs on site. (drshrutibhat.com)
  • The system has been used in various tissues and organs (in vitro or in vivo), including tumor tissues, kidney, cardiac, skeletal muscle, and vascular smooth muscle. (hindawi.com)
  • However, the microsized particles could only stay in blood circulation and penetrate poorly into tumor tissues, so that the wide application of the particles for in vivo tumor therapy is limited [ 3 ]. (hindawi.com)
  • Strategies have been advised that nanoparticles can be used to deliver drug/gene to targeted tissues [ 4 ]. (hindawi.com)
  • Nanoparticle, used as a drug/gene delivery vehicle, can not only target specific cells and tissues, but also retain the biological activity of the drug/gene during transport. (hindawi.com)
  • The small packaging allows nanoparticles to extravasate into tumor tissues. (hindawi.com)
  • Ultrasonic drug and gene delivery from nanocarriers have tremendous potential because of the wide variety of drugs and genes that could be delivered to targeted tissues by fairly noninvasive means [ 7 ]. (hindawi.com)
  • Besides, nanocarriers decorated with targeting moiety can adhere to targeted tissues, which can promote intracellular uptake of drug delivery vehicles. (hindawi.com)
  • Most of them generally follow the same pathway to make immune-activated cytotoxic T lymphocytes (CTLs) abundantly infiltrate into tumor tissues and destroy tumor cells [ 6 ]. (thno.org)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • One of the biggest challenges in cancer therapy is being able to sufficiently deliver chemotherapy drugs to tumors without exposing healthy tissues to their toxic effects. (innovationtoronto.com)
  • The nanocarriers are designed so they're only taken up by cancer cells, thereby preventing the drugs from being absorbed by healthy tissues as they travel through the body's circulation. (innovationtoronto.com)
  • Yet while nanocarriers do a good job protecting healthy tissues, the amount of drug successfully delivered to tumors remains low. (innovationtoronto.com)
  • An overview of the state-of-the-art using albumin as drug carrier for specific accumulation in tumors and inflammatory cells using the advantageous properties of native albumin is given in this review. (nih.gov)
  • To be able to steer the particles specifically towards cancer tissue, the researchers also mixed superparamagnetic iron oxide particles in with the gold particles, which enable the nanoaggregates to be controlled via magnetic fields and may enhance their accumulation in a tumour. (meddeviceonline.com)
  • No. 4,975,278) allows targeted delivery of the drug moiety to tumors, and intracellular accumulation therein, where systemic administration of these unconjugated drug agents may result in unacceptable levels of toxicity to normal cells as well as the tumor cells sought to be eliminated (Baldwin et al (1986) Lancet pp. (justia.com)
  • 2009 ). Nanocarriers provide additional advantages for tumor treatment since the conjugate of the anticancer drug with different carriers may reduce systemic toxicity and enhance drug accumulation in malignant tissue (Feng et al. (biomedcentral.com)
  • PEG also minimizes the nonspecific absorption of the drug, provides specific affinity toward the targeted tumor, and increases the drug accumulation in malignant tissue (Heffeter et al. (biomedcentral.com)
  • The human body overall tends to have a more alkaline pH level of 7.4 while tumor tissue ranges from 7.0- 7.2 pH level, which is known as tumor acidosis. (wikipedia.org)
  • Tumor hypoxia occurs when a tumor's environment has low or severely depleted oxygen levels compared to healthy tissue, which could lead to tumor acidosis. (wikipedia.org)
  • The purpose of the pH- triggered drug release is to deliver the drug precisely to the area of the tumor and not activate and release the drug in healthy tissue. (wikipedia.org)
  • There is no doubt that the term "regenerative medicine" to open a new space of tissue reconstruction, but the complications that arise due to the proper machinery of the cell, supporting biomaterials and growth factors has yet to be resolved to expand its application in a versatile manner. (intechopen.com)
  • The chapter would provide a significant overview of the artificial tissue regeneration while a triangular relationship between cells, matrixes, and growth factors should be established mentioning the necessity of biomedical tools as an alternative to organ transplantation. (intechopen.com)
  • As a result, only a few bacteria manage to navigate from the bloodstream through dense tissue to finally reach their targeted tumor. (e-flux.com)
  • These bacteria serve as drug carriers and are controlled by a magnetic field to help them overcome cell and tissue barriers and direct them to the tumor site. (e-flux.com)
  • The artwork's outer walls resemble images of the cosmos, yet they portray a model of cancer tissue made up of tissue fibers, a mass of cancer cells, and swarming bacteria. (e-flux.com)
  • Direct application of drug molecules to the diseased tissue or organ increases the effect of the therapy and decreases the side effects. (europa.eu)
  • MDimune is expanding its global network to harness effective tissue targeting strategy to achieve highly tissue-specific drug delivery. (biospace.com)
  • Biocompatible materials, such as polycaprolactone (PCL), have been used extensively to fabricate scaffolds using electrospinning technique, to study cell compatibility and to evaluate cell functionality for nerve tissue engineering applications. (asme.org)
  • As a new type of probe, the heavy isotope of water has been widely used in the study of cell development, metabolism, tissue homeostasis, aging, and tumor heterogeneity. (medsci.org)
  • Nanomaterials have demonstrated a wide range of applications and recently, novel biomedical studies are devoted to improving the functionality and effectivity of traditional and unmodified systems, either drug carriers and common scaffolds for tissue engineering or advanced hydrogels for wound healing purposes. (researchgate.net)
  • This route promises a novel approach to tissue engineering and presents variety of applications in bringing about modifications of tumor cells that could increase their uptake of drugs. (drshrutibhat.com)
  • These effects may induce transient membrane permeabilization (sonoporation) on a single cell level, cell death, and disruption of tissue structure, ensuring noninvasive, targeted, and efficient drug/gene delivery and therapy. (hindawi.com)
  • The potential approach is to develop particular carriers which can facilitate the release of the payload locally in tissue by internal or external stimuli (such as heat, light, ultrasound, etc. (hindawi.com)
  • This could enable them to kill tumour tissue with heat, for instance. (meddeviceonline.com)
  • In addition, differences in pressure between the tumor and its surrounding tissue prevent nanocarriers from penetrating deep inside the tumor. (innovationtoronto.com)
  • The injection was made into the tissue directly adjacent to the tumors after which the mice were exposed to a computer-programmed magnetic field, meant to direct the cells or beads into the tumor. (innovationtoronto.com)
  • For example, excessive inhibition by which tissue remodeling takes place during normal of apoptosis is an underlying mechanism of cancer, while growth and development and the physiologic mechanism an inappropriate increase is seen in some neurodegenera- by which labile cell populations such as gastrointestinal tive diseases and other conditions. (cdc.gov)
  • Depending on the introduced functional group's acid dissociation constant (pKa), drug release from these nanocarriers can occur through precipitation, aggregation, or dissociation mechanisms. (wikipedia.org)
  • With the advancement of nanocarriers for drug delivery into biomedical practice, assessments of drug susceptibility to oxidative degradation by enzymatic mechanisms of inflammatory cells become important. (cdc.gov)
  • With the development of nanotechnology, nanocarriers have been increasingly used for curative drug/gene delivery. (hindawi.com)
  • As a novel theranostic system, nanocarriers hold great promise for ultrasound molecular imaging, targeted drug/gene delivery, and therapy. (hindawi.com)
  • Nanocarriers can pass through blood capillary walls and cell membrane walls to deliver drugs. (hindawi.com)
  • In this review, we explore the research progress and application of ultrasound-mediated local drug/gene delivery with nanocarriers. (hindawi.com)
  • Furthermore, as targeted delivery carriers, gene/drug-loaded nanocarriers can release their associated payload upon insonation. (hindawi.com)
  • Although the system of ultrasound-mediated drug delivery with nanocarriers has many advantages, there are still many challenges. (hindawi.com)
  • In the last two decades, lipid and polymer-based nanocarriers have been studied as alternative drug delivery systems that can enhance the solubility of drugs by encapsulating existing and new anticancer drugs (Feng et al. (biomedcentral.com)
  • In modern pharmacology, polymeric nanocarriers (PNCs) are the most promising drug delivery platforms for anticancer drugs (Han et al. (biomedcentral.com)
  • One way researchers have attempted to overcome this is by developing nanocarriers-extremely small particles packed with drugs. (innovationtoronto.com)
  • The main reasons for this shortcoming are that nanocarriers rely on the circulation system to carry them to the tumor, so a large percentage are filtered out of the body before ever reaching their destination. (innovationtoronto.com)
  • As a result, nanocarriers aren't able to reach the tumor's hypoxic zones, which are regions of active cell division that are characterized by low oxygen content. (innovationtoronto.com)
  • For comparison, some researchers estimate that only approximately 2% of drugs delivered via current nanocarriers make it into tumors. (innovationtoronto.com)
  • The carrier compromises pH-sensitive molecules, which allows the drug vehicle to activate at the tumor site at the optimal pH range it is set to get triggered at and release the drug. (wikipedia.org)
  • While one of these segments is ornamented with active drug molecules, the other one can be decorated with targeting groups. (europa.eu)
  • Conjugating drug molecules onto dendrimers containing targeting moieties can improve all of these shortcomings. (europa.eu)
  • The research that started with this project has evolved into three parts: The first part is the synthesis of dendrons (dendrimer pieces) with targeting groups, the second part is the attachment of drug molecules to another dendron and the third and final part is the development of methodology for putting these two pieces together. (europa.eu)
  • The CAR-containing exosomes express a high level of cytotoxic molecules and inhibit tumour growth. (nature.com)
  • Lipid-based nanoparticle (LBNP) systems represent one of the most promising colloidal carriers for bioactive organic molecules. (mdpi.com)
  • The groups of sialic acid derivatives- "landscape cell" that is chemically unique to the cell surface is being used as a " chemical handle" for attaching molecular probes or various bio molecules. (drshrutibhat.com)
  • Drug moieties used in antibody drug conjugates include bacterial protein toxins such as diphtheria toxin, plant protein toxins such as ricin, small molecules such as auristatins, geldanamycin (Mandler et al (2000) J. of the Nat. (justia.com)
  • Polymer-based therapeutics has been established as an innovative and dependable method, since the PNC can conjugate with a wide variety of molecules and compounds (e.g., proteins, enzymes, nanoparticles, liposomes, low molecular weight drugs) (Wang et al. (biomedcentral.com)
  • In addition, validation of preliminary findings of solute carrier molecules (usually used for drug-delivery) selectively expressed in tumor cells with the aim to develop imaging-led theranostic approaches of personalized treatment will be performed. (lu.se)
  • Autophagy is a pathway for cells to degrade intracellular components that are no longer needed or are detrimental for the cells. (helsinki.fi)
  • Typically, CARs consist of a target binding domain, which is an extracellular domain that is specifically expressed by CAR-T cells, a transmembrane domain, and a signalling domain, which is an intracellular domain that provides an activation signal to T cells. (nature.com)
  • Positively charged CTAC could actively target mitochondria by interacting with the negatively charged mitochondria membrane, and then lead to the dysfunction of mitochondria by decreasing mitochondrial potential and intracellular ATP levels, resulting in the necrosis and apoptosis of MCF-7 cells. (rsc.org)
  • Even after arriving at their sites of action, prior to the release of their cargo and clearance, NPs must effectively penetrate through the cell membrane and navigate intracellular compartment networks to get to their subcellular mark. (biomedcentral.com)
  • Fucoidan-coated copper sulfide nanoparticles (F-CuS) act not only as a nanocarrier to enhance the intracellular delivery of fucoidan but also as a photothermal agent to effectively ablate different cancer cells (e.g. (oncotarget.com)
  • These results indicate that in addition to systemic chemotherapy, an adjuvant nHA could be used as a carrier for intracellular delivery of DOX for prevention of tumor recurrence after surgical resection in an osteosarcoma. (lu.se)
  • To circumvent the blood-brain barrier, a natural impediment for efficient drug delivery to the brain, researchers at the Cancer Epigenetics lab are developing, in collaboration with the Department of Materials Science and Engineering at the University of Delaware, a nano-hydrogel approach for direct drug delivery to brain tumors. (une.edu)
  • Animal studies have shown that hyaluronan bound cyclosporine is more effective than cyclosporine alone in promoting cell death in colorectal tumors. (drshrutibhat.com)
  • In an initial experiment, mice that had been given human colorectal tumors were injected with either live MC-1 cells, dead MC-1 cells, or as a control group, non-magnetic beads (roughly the same size as the bacteria). (innovationtoronto.com)
  • The cells were then injected into another set of mice with colorectal tumors and exposed to the magnet. (innovationtoronto.com)
  • Stromal tumors of the ovary include germ-cell tumors, sex-cord stromal tumors, and other more rare types. (medscape.com)
  • Scientists have used drug delivery as a way to modify the pharmacokinetics and targeted action of a drug by combining it with various excipients, drug carriers, and medical devices. (wikipedia.org)
  • Dosimetry-guided RPT (DG-RPT) helps tailor treatment plans to fit a patient's individual drug-interaction (pharmacokinetics). (voximetry.com)
  • Torch™ simplifies the otherwise complex task of analyzing a patient's nuclear medicine scans to develop a personalized assessment, including estimates of patient-specific pharmacokinetics and calculation of dose to the patient's tumors and critical structures. (voximetry.com)
  • Initial computed tomography (CT) revealed tumor growth along with an increase in tumor markers, and contrast-enhanced ultrasonography (CEUS) showed multiple round avascular areas within the nodules with an appearance similar to a slice of Swiss cheese. (bvsalud.org)
  • This is also especially relevant as most of the popular anticancer drugs possess serious side-effects due to unspecific action on healthy cells. (exposed-skin-care.net)
  • In the evolution of modern biopharmaceuticals, some of the main tasks are to develop safe nanosized carriers that have low toxicity, physical stability in blood, compatibility with metabolites of the organism, also controlled impact on cells' damage, and the potential to improve targeted delivery of anticancer drugs to tumors (Nath Roy et al. (biomedcentral.com)
  • Two of the limitations associated with cancer treatment are the low efficacy and the high dose-related side effects of anticancer drugs. (beilstein-journals.org)
  • A lot of questions still need to be answered before the particles can be used in humans", says Jean-Christophe Leroux, Professor of Drug Formulation and Delivery at ETH Zurich, who was also involved in the research project. (meddeviceonline.com)
  • In the past biennium, working groups have concluded that there is sufficient evidence to classify infection with human immunodeficiency virus (HIV-1), human T-cell lymphotropic virus (HTLV-1), Epstein-Barr virus (EBV) and the Kaposi sarcoma-associated herpesvirus 8 as carcinogenic to humans (IARC 0RQRJUDSKV, Vol. 67 and 70). (who.int)
  • Extensive lymphocyte severe infections is a massive loss of lymphocytes, den- apoptosis has also occurred in humans and animals infect- dritic cells, gastrointestial epithelial cells, and other cell ed with several exotic agents, including Bacillus anthracis , types through apoptosis, or programmed cell death. (cdc.gov)
  • This form of targeted drug delivery is to localize drug delivery, prolongs the drug's effect, and protect the drug from being broken down or eliminated by the body before it reaches the tumor. (wikipedia.org)
  • One approach involves the use of creating drug delivery carriers that are sensitive to pH levels and have triggered drug release at the tumor site, thereby enhancing the efficacy of chemotherapy and other treatments. (wikipedia.org)
  • pH-responsive tumor-targeted drug delivery detects the changes in the pH within the body. (wikipedia.org)
  • Another possible carrier could be lipid-based, and a drop in pH can cleave the covalent acid-labile bonds on the surface and within the carrier leading to swelling of the drug delivery system and then release of the drug at a specific rate. (wikipedia.org)
  • Studies have shown pH-responsive tumor-targeted drug delivery carriers to have advantages. (wikipedia.org)
  • To get into the cell nevertheless, many drugs hence have to rely on supramolecular drug delivery systems. (uu.nl)
  • Such nano-scale drug delivery systems need to be smart and tunable materials, since many hurdles have to be overcome to get a drug into cell (Figure 1). (uu.nl)
  • BBB restricts drugs transport from blood stream to the brain, which sets challenges in drug delivery to the brain. (helsinki.fi)
  • Nanoparticles can be utilized in drug delivery to the central nervous system (CNS). (helsinki.fi)
  • The characterization of BBB cells would help light on the exact mechanism of nanoparticle delivery into the brain, which would enable the design of targeted nanoparticles to deliver drugs to the CNS. (helsinki.fi)
  • The development of bioinformatics technology has enabled nanomedicine to play a significant role in drug delivery systems. (frontiersin.org)
  • The two-dimensional nano drug carrier has high safety and effectiveness in drug delivery, and its targeted treatment effect on acute T lymphoblastic leukemia cells is obvious. (frontiersin.org)
  • Drug delivery systems seem to be a new method for improving drug targeting and release into cells, bringing new opportunities for improving drug efficiency and avoiding potential side effects. (frontiersin.org)
  • The key parameters for successful treatment using nanodelivery systems are essential selectivity biological activity effectiveness of uptake and drug concentration.6 In basic principle nanoparticulate delivery systems can be used to target anticancer medicines to tumor cells by either passive or active targeting (Fig.?1). (exposed-skin-care.net)
  • Thermo-responsive Fibrinogen Nanogels: a Viable Thermo-responsive Drug Delivery Agent for Breast Cancer Therapy? (amrita.edu)
  • Arthrobotrys oligospora 's nanoparticles may thus have important applications for chemotherapy, drug delivery, and immune regulation. (chemistryviews.org)
  • Smart drug delivery systems (SDDSs) for cancer treatment are of considerable interest in the field of theranostics. (nature.com)
  • However, developing SDDSs with early diagnostic capability, enhanced drug delivery and efficient biodegradability still remains a scientific challenge. (nature.com)
  • Genetically engineering red blood cells to turn them into drug-delivery vehicles could open the door to a vast number of new therapies. (technologyreview.com)
  • One of the promising areas of research involves targeted drug delivery where the medicine is carried by a vehicle that finds and gets taken up by tumour cells and then kills the cancer. (europa.eu)
  • In this on-going research, we are trying to explore dendrimers as drug delivery agents. (europa.eu)
  • Multifunctional dendrimers have a high potential for drug delivery applications as they accommodate a high density and wide variety of functional groups on their surface. (europa.eu)
  • therefore, variations both in a disease state and in drug plasma concentration need to be taken into consideration in developing drug delivery systems intended for the treatment of disease with adequate dose. (scialert.net)
  • PSDDS wherein the drug release is controlled primarily by the delivery system, stimuli induced PSDDS in which release is controlled by the stimuli, such as the pH present in the intestinal tract. (scialert.net)
  • Controlled drug delivery systems, which are intended to deliver drugs at predetermined rates for predefined periods of time, have been used to overcome the shortcomings of conventional drug formulations. (scialert.net)
  • Although, significant progress has been made in the controlled drug delivery area, more advances are yet to be made for treating many clinical disorders, such as diabetes and rhythmic heart disorders. (scialert.net)
  • In addition, the controlled drug delivery area needs further development of techniques for delivery of peptide and protein drugs. (scialert.net)
  • Such a system would require coupling of the drug delivery rate with the physiological need by means of some feedback mechanism. (scialert.net)
  • MDimune Inc. and Evercyte GmbH announced a strategic collaboration to develop tumor-targeted drug delivery by combining MDimune's BioDrone® platform technology based on cell-derived vesicles (CDVs) and Evercyte's technology to modify surface proteins to create tumor-specific binding affinity. (biospace.com)
  • Thereby, Evercyte can identify and isolate high-affinity binders to any surface molecule including specific tumor antigens, which then turns EVs, such as CDVs, into targeted drug delivery vehicles. (biospace.com)
  • Seung Wook Oh, Ph.D., Chief Scientific Officer of MDimune emphasized that "the collaboration with Evercyte will provide an extremely interesting opportunity for MDimune to move forward to achieving selective drug delivery. (biospace.com)
  • The superior productivity of CDVs, compared to other EVs such as exosomes, will surely facilitate the development of tumor-targeted drug delivery approach," said Dr. Oh. (biospace.com)
  • BioDrone® is an innovative technology that relies on human-sourced CDVs, nanosized vesicles obtained from various cells by using a proprietary extrusion method to achieve target-specific drug delivery. (biospace.com)
  • Sesame oil is a potential lipophilic component in emulgel formulations for topical delivery of hydrophobic drugs. (ajol.info)
  • Engineering the drug carrier biointerface can help overcome the main biological barriers and optimize the drug delivery in a more personalized manner. (biomedcentral.com)
  • This review discusses the significant heterogeneous biological delivery barriers and how biointerface engineering can promote drug carriers to prevail over hurdles and navigate in a more personalized manner, thus ushering in the era of Precision Medicine. (biomedcentral.com)
  • Although this is a significant step forward in achieving targeted drug delivery, the drug carrier must have to overcome various biological obstacles throughout the body to reach the specific target of interest. (biomedcentral.com)
  • Introduction: Liposomes as drug delivery systems has been widely studied as a way to solubilize poorly soluble drugs, reduce side effects of chemotherapeutics and increase circulation time in vivo. (uit.no)
  • Smart materials that can be triggered by external stimuli are seen with high potential for innovative treatments and improved drug delivery systems by regulatory agencies like the FDA and EMA. (researchgate.net)
  • Design of Nanoparticle-Based Carriers for Targeted Drug Delivery. (researcher-app.com)
  • Nanoparticles have shown promise as both drug delivery vehicles and direct antitumor systems, but they must be properly designed in order to maximize efficacy. (researcher-app.com)
  • In this article, we provide an overview of three different targeted drug delivery methods (passive targeting, active targeting and physical targeting), compare methods of action, advantages, limitations, and the current stage of research. (researcher-app.com)
  • This is followed by a review of computational simulations and models on nanoparticle-based drug delivery. (researcher-app.com)
  • However, despite the similarity between these peptides and others that are arginine-rich, and efficient vectors, functional studies suggest the need for additional modifications in the carriers to improve their DNA delivery efficiency. (ox.ac.uk)
  • Alongside development of new delivery presentations as well as biotech based actives such as peptides, a new biochemical pathway based on carbohydrates uptake and metabolism using cell surface "landscape" engineering technique is currently being investigated. (drshrutibhat.com)
  • In the next post I shall take up challenges in Controlled release drug delivery systems. (drshrutibhat.com)
  • Microbubbles are commonly used as intravascular ultrasound imaging probes and are becoming increasingly popular tools for targeted drug delivery. (hindawi.com)
  • they target tumor cells through the phagocytosis or endocytosis of NPs, and therefore, they are suitable for the delivery of chemotherapeutics in cancer treatment [ 1 ]. (oncotarget.com)
  • The use of antibody-drug conjugates (ADC), i.e. immunoconjugates, for the local delivery of cytotoxic or cytostatic agents, i.e. drugs to kill or inhibit tumor cells in the treatment of cancer (Lambert, J. (2005) Curr. (justia.com)
  • To overcome drug resistance, novel drug delivery systems based on nanoparticles have had remarkable success. (johnshopkins.edu)
  • The reduced toxicity of this PNC in combination with its improved bioavailability and previously detected capability to enhance cytotoxicity toward tumor cells in vitro and potential tumor treatment effects in vivo suggests its potential as a safe drug delivery platform for treating various diseases, especially cancer. (biomedcentral.com)
  • 2009 ). In these ways, nanocarrier-based drug delivery will improve the efficacy of anticancer chemotherapy (Wang et al. (biomedcentral.com)
  • Increasing the clinical efficacy of toxic chemotherapy drugs such as cisplatin (CDDP), via targeted drug delivery, is a key area of research in cancer treatment. (ox.ac.uk)
  • The ability to actively and precisely target drug delivery to a tumor will help reduce side effects and potentially improve the efficacy of treatments. (innovationtoronto.com)
  • Efficient systemic pharmacological treatment of solid tumors is hampered by inadequate tumor concentration of cytostatics necessitating development of smart local drug delivery systems. (lu.se)
  • In order to evaluate the anti-cancer effect of MDC, we conducted in vitro and in vivo experiments on cancer cell lines and a primary tumor derived breast xenograft. (johnshopkins.edu)
  • The high potential of the PEGylated comb-like polymeric nanocarrier (PNC) in delivering both traditional and experimental drugs to tumor cells in vitro and in vivo has been demonstrated previously. (biomedcentral.com)
  • Cancer tumor may be developed with a multistep carcinogenesis procedure entailing numerous mobile physiological systems such as for example cell signaling and apoptosis.3 Cancers includes a physiological hurdle like vascular endothelial skin pores heterogeneous blood circulation heterogeneous structures etc. (exposed-skin-care.net)
  • Mutant K-RAS has been shown to have both tumor-promoting and -suppressing functions, and growing evidence suggests that the RASSF family of tumor suppressors can act as RAS apoptosis and senescence effectors. (cancerindex.org)
  • The released DOX then accumulates in the mitochondria causing cell starvation, reduced migration and apoptosis. (lu.se)
  • Locally delivered DOX via the HA particles had a stronger tumor eradication effect compared to the controls as seen by PET-CT and immunohistochemical staining of proliferation and apoptosis markers. (lu.se)
  • Prevention of lymphocyte apoptosis, same process by which these cell populations are regulat- through either genetic modification of the host or treatment ed during normal health ( 1 , 2 ). (cdc.gov)
  • acquired defects in the control of apoptosis may lead to a Apoptosis, or programmed cell death, is the method variety of disease states. (cdc.gov)
  • In the proposed master project, the student will investigate the supramolecular structure and dynamics of a peptide-based drug vector for gene therapy. (uu.nl)
  • Experimental analysis was also conducted on the characterization ability, drug release, and targeted therapy of nanomedicine. (frontiersin.org)
  • Its drug release characteristics perform well in photothermal therapy, indicating that black phosphorus nano drugs can improve the biological safety and applicability of drugs in new tumor targeted therapy. (frontiersin.org)
  • Targeted therapy uses targeted drugs to maintain a high concentration of the drug in the tumor area, improving the killing efficiency of cancer cells while avoiding damage to other normal cells. (frontiersin.org)
  • Smartly engineered nanocapsules can not only shrink and decompose into small-sized nanodrugs upon drug release but also can regulate the TME to overproduce reactive oxygen species for enhanced synergistic therapy in tumors. (nature.com)
  • In addition to the PKU therapy, Rubius has developed over 50 different therapies based on red blood cells, says Avak Kahvejian , the company's CEO and a partner at Flagship. (technologyreview.com)
  • Before they become fully mature, mammalian red blood cells eject their genetic material, so as a therapy they are easier to control and less risky than other stem cell and gene therapies, which can lead to abnormal cell growth and tumors. (technologyreview.com)
  • Lodish says animal tests suggest that engineered red blood cells can be a "very potent" therapy for a range of diseases. (technologyreview.com)
  • These stem cells have renowned ability for use in cell therapy and organ regeneration. (asme.org)
  • Because a patient's drug interaction may change over the course of therapy, it is important to have the ability to adapt the treatment plan in response. (voximetry.com)
  • 4 The mitochondrial membrane potential of cancer cells (∼−220 mV) is more negative than that of normal cells (∼−160 mV). 5 Therefore, mitochondria have been regarded as a novel target for cancer therapy. (rsc.org)
  • However, the therapy impacts the entire body, damaging healthy cells as well and resulting in side effects which are sometimes quite serious. (tum.de)
  • They can pass through blood capillary walls and cell membrane walls to deliver drugs [ 8 ], thereby reducing the side effect and enhancing the curative effect of cancer therapy [ 9 ]. (hindawi.com)
  • IL-2 and IFN-γ), immune checkpoint blockade (ICB) therapy (e.g., anti-PD-1/PD-L1 antibodies), and adoptive T-cell transfer (e.g., chimeric antigen receptor (CAR) T-cell therapy) [ 3 - 5 ]. (thno.org)
  • In the present study, using a facile, low-cost, and solution-based method, we developed and synthesized fucoidan, a natural polymer isolated from seaweed that has demonstrated anti-cancer effect, and coated NPs with it as an ideal candidate in chemo-photothermal therapy against cancer cells. (oncotarget.com)
  • Transmembrane or otherwise tumor-associated polypeptides specifically expressed on the surface of cancer cells as compared to normal, non-cancerous cell(s) have been identified as cellular targets for cancer diagnosis and therapy with antibodies. (justia.com)
  • Thorpe, (1985) "Antibody Carriers Of Cytotoxic Agents In Cancer Therapy: A Review," in Monoclonal Antibodies '84: Biological And Clinical Applications, A. Pinchera et al (ed.s), pp. 475-506). (justia.com)
  • The purpose of the current study was to fabricate biocompatible multifunctional drug-loaded nanoscale moieties for co-therapy (chemo-photothermal therapy) with maximum efficacy and minimum side effects. (beilstein-journals.org)
  • Hypoxia: Importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy, Int J Radiat Biol, 82, 699 (2006). (dergipark.org.tr)
  • These cells are not killed by conventional cancer therapy and thus it is critical to identify those cancer stem cells to be able to improved diagnostics and treatment of cancer. (lu.se)
  • For randomisation of solid tumour participants: Gut distress symptoms related to their cancer therapy defined by a score of greater or equal to 1 in the MDQ and confirmed by research nurse. (who.int)
  • It has also been shown that metformin and phenformin inhibit tumor growth by disrupting mitochondrial complex. (rsc.org)
  • Its low toxicity, high efficiency, and controllable drug release advantages make it have good application effects. (frontiersin.org)
  • lipid carriers (C-D-NLC) inhibited the growth of LLC tumors in mice and reduced drug toxicity. (ajol.info)
  • CTAB has been shown as a promising compound against head and neck cancer cells with minimal toxicity against normal fibroblasts, as well as a tumoricidal irritant in colorectal cancer surgery. (rsc.org)
  • Since the natural products show an efficient anti-cancer effect without imposing any toxicity on normal cells, they are promising as an alternative to chemical drugs [ 2 ]. (oncotarget.com)
  • It is essential for cell homeostasis and survival and has been related to various diseases and pathophysiology. (helsinki.fi)
  • A personalized treatment can potentially lead to longer overall survival, increased tumor response, and higher quality of life. (voximetry.com)
  • Associations of a Breast Cancer Polygenic Risk Score With Tumor Characteristics and Survival. (cancercentrum.se)
  • Since mucins occur naturally in the body, opened mucin particles can later be broken down by the cells," Lieleg says. (tum.de)
  • In order to use them as keys, we modified the lock accordingly by meticulously designing the synthetic DNA strands which stabilize our medication carrier particles. (tum.de)
  • The researchers have already tested the new particles on breast cancer cells in a Petri dish and discovered that after exposure to near-infrared light the nanoparticles heated up sufficiently to kill off the cells, while cells survived in control experiments (with particles but without radiation and with radiation but without nanoparticles). (meddeviceonline.com)
  • You could even couple the particles with temperature-responsive drug carriers, which would then allow the drug release if a certain temperature were exceeded", explains Sotiriou. (meddeviceonline.com)
  • Tumor acidosis can occur due to various factors, including hypoxia, the Warburg effect, and the release of acidic metabolites by the tumor cells. (wikipedia.org)
  • Numerous studies show that high levels of hypoxia inducible transcription factors, HIF-1 α and HIF-2 α , also correlate to aggressive tumor disease. (lu.se)
  • Identification of such tumor-associated cell surface antigen polypeptides, i.e. tumor associated antigens (TAA), allows specific targeting of cancer cells for destruction via antibody-based therapies. (justia.com)
  • We also summarize the nanomedicines' current advantages and disadvantages in drug administration, from natural/synthetic sources to clinical applications. (biomedcentral.com)
  • Wei X, Wang J, Liang M, Song M. Development of functional nanomedicines for tumor associated macrophages-focused cancer immunotherapy. (thno.org)
  • Here, the underlying mechanisms of tumor immunosuppression caused by TAMs are first emphatically elucidated, and then the basic design of TAMs-focused immune-nanomedicines are discussed, mainly including diverse categories of nanomaterials, targeted and stimulus-responsive modifications, and TAM imaging in nanomedicines. (thno.org)
  • Greish, K.: Enhanced permeability and retention of macromolecular drugs in solid tumors: A royal gate for targeted anticancer nanomedicines, J Drug Target, 15, 457 (2007). (dergipark.org.tr)
  • The Warburg Effect refers to cancer cells using aerobic glycolysis for cell metabolism, which results in an increased rate of glucose uptake and a preference for lactate production, despite the presence of oxygen. (wikipedia.org)
  • Studies have shown the uptake of the drug in tumors or critical organs can vary as much as five-fold between patients. (voximetry.com)
  • Drug carriers such as albumin have been used to target specifically diseased and malignant cells, resulting in higher efficacy of treatment and reduced side effects. (nih.gov)
  • When those data were "very encouraging," Alani's team assessed the efficacy of the formulations in mice that had tumors grafted into them. (medgadget.com)
  • The rapid advancement of nanomedicine and nanoparticle (NP) materials presents novel solutions potentially capable of revolutionizing health care by improving efficacy, bioavailability, drug targeting, and safety. (biomedcentral.com)
  • The CS NPs were effectively internalized into the endolysosomal compartments of cancer cells and demonstrated an increased cytotoxic efficacy (concentration of a drug that gives half maximal response [EC50] reaching 6.2 µM) compared to free drug (EC50 =9 µM) and uniform CDDP-distributed NPs (EC50 =7.6 µM) in vitro. (ox.ac.uk)
  • The Effect of the Kirsten Rat Sarcoma Viral Oncogene Homolog (Kras) Proto-Oncogene, GTPase Genetic Polymorphism on the Safety and Efficacy of Bevacizumab Combination Treatment Regimens for Patients with Nonsquamous, Non-Small Cell Lung Cancer with Brain Metastases. (cdc.gov)
  • He says not-yet-published work from his lab has shown that cells modified to produce an antibody to a specific bacterial toxin render mice resistant to many times the lethal dose of that toxin. (technologyreview.com)
  • Without any liposome, the drug showed some tumor suppression, but the mice that had received the drug alone had to be euthanized after 70 days because of tumors that were no longer being controlled. (medgadget.com)
  • Mice that had received the drug with one of the liposomes were healthy and tumor-free for the nearly 100-day run of the experiment. (medgadget.com)
  • After examining the tumors of those mice, the researchers estimated that on average, 55% of the injected bacterial cells with attached vesicles made it into the tumor. (innovationtoronto.com)
  • 1986. Immunomodulation by polyaromatic hydrocarbons in mice and murine cells. (cdc.gov)
  • The cell-surface antigen or receptor should be homogeneously and specifically portrayed on tumor cells and really should not end up being shed in to the blood flow.5 Targeted nano. (exposed-skin-care.net)
  • Genetically engineered T cells expressing a chimeric antigen receptor (CAR) are rapidly emerging a promising new treatment for haematological and non-haematological malignancies. (nature.com)
  • In addition, we revealed that the cytostatic and cytotoxic effects of free Doxorubicin, but not nanotube -carried drug, on melanoma and lung carcinoma cell lines were abolished in the presence of tumor-activated myeloid regulatory cells that create unique myeloperoxidase- and peroxynitrite-induced oxidative conditions. (cdc.gov)
  • Since rate of autophagy in cells was not detected, it is impossible to determine, if there were changes in autophagy that were not reflected as changes in colocalization of these two proteins. (helsinki.fi)
  • To characterize hCMEC/D3 cells for the presence of specific endocytic pathways, proteins involved into each pathway were selected. (helsinki.fi)
  • Among most immunosuppressive cells, TAMs, as crucial drivers of immunosuppressive TME, account for the largest proportion of immune cells in the TME (approximately 50% of tumor mass) [ 9 , 10 ], which possess highly heterogeneity and play a complex regulatory role in tumor immunity and immunotherapy due to helping tumor evade immune surveillance [ 11 ]. (thno.org)
  • 1 It has become increasingly evident that mitochondria play a key role in the generation, proliferation and metastasis of cancer cells. (rsc.org)
  • Only a very small proportion of drugs reach the hypoxic zones, which are believed to be the source of metastasis. (innovationtoronto.com)
  • Noninvasive prediction of axillary lymph node breast cancer metastasis using morphometric analysis of nodal tumor microvessels in a contrast-free ultrasound approach. (medscape.com)
  • Furthermore, it is well known that solid tumors experience impaired oxygenation due to inadequate vascularization. (lu.se)
  • Correction: Changes in the tumor oxygenation but not in the tumor volume and tumor vascularization reflect early response of breast cancer to neoadjuvant chemotherapy. (medscape.com)
  • The researchers loaded this prodrug into liposomes, vesicles made of lipids, and delivered it into animals with non-small cell lung cancer. (medgadget.com)
  • Efforts have been made to increase drug carrier targeting efficiency by attaching cell receptor-targeted ligands to the particle surface [ 7 ]. (biomedcentral.com)
  • L-selectin (on leukocyte), E-selectin and P-selectin (on endothelial cell wall) participate in the inflammatory response, each interacting with specific glycoprotein ligands. (drshrutibhat.com)
  • The cysteine engineered antibodies may be conjugated with chemotherapeutic drugs, toxins, affinity ligands such as biotin, and detection labels such as fluorophores. (justia.com)
  • Some cytotoxic drugs tend to be inactive or less active when conjugated to large antibodies or protein receptor ligands. (justia.com)
  • Particularly, hyaluronic acid and its derivatives bind with high affinity to cell surface protein, CD44 enriched tumor cells. (intechopen.com)
  • When tested in normal ovarian surface epithelial and ovarian clear cell carcinoma cell culture models, encapsulation of TPPS in cESG significantly improved cell death in response to light treatment compared to free drug alone. (nih.gov)
  • The bacteria are loaded with miniature "drug backpacks," promising a more targeted and effective treatment approach for tumors. (e-flux.com)
  • Compared with CAR-T cells, CAR exosomes do not express Programmed cell Death protein 1 (PD1), and their antitumour effect cannot be weakened by recombinant PD-L1 treatment. (nature.com)
  • Although a strong response was observed for CAR-T cells in patients with treatment-refractory haematologic malignancies, only modest outcomes have been reported in solid tumours. (nature.com)
  • 10-12 Noticeably, cationic surfactant is more extensively used in tumor treatment than other types of surfactants, such as anionic and nonionic surfactant. (rsc.org)
  • Herein, we review findings supporting the applications of and research on heavy water in monitoring of bacterial metabolism, rapid detection of drug sensitivity, identification of tumor cells, precision medicine, and evaluation of skin barrier function and promote the use of heavy water as a suitable marker for the development of detection and treatment methodologies. (medsci.org)
  • These magneto-responsive devices can be used for a multitude of biomedical applications, from diagnostic to the treatment of tumors, and are actively being developed and tested for cancer theranostics. (researchgate.net)
  • Tumor imaging should be performed before and during the external stimuli or treatment. (hindawi.com)
  • The invention also relates to methods of using antibodies and antibody-drug conjugate compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions. (justia.com)
  • To overcome this, we demonstrate that doxorubicin (DOX), a cornerstone drug used for osteosarcoma treatment, shows reversible accretion to hydroxyapatite (HA) of both nano (nHA) and micro (mHA) size. (lu.se)
  • In addition, we differentiate for the first time the contributions of ERBB1 and ERBB2 to the key metastatic properties of in vivo tumor cell invasion and intravasation. (aacrjournals.org)
  • Breast metastatic tumors in lung can be substituted by lung-derived malignant cells transformed by alternative splicing H19 lncRNA. (medscape.com)
  • Dynamic changes in RAS gene status in circulating tumour DNA: a phase II trial of first-line FOLFOXIRI plus bevacizumab for RAS-mutant metastatic colorectal cancer (JACCRO CC-11). (cdc.gov)
  • It causes malignant proliferation of hematopoietic stem cells in the bone marrow, resulting in the production of cancerous cells that lack normal physiological functions. (frontiersin.org)
  • The new technology draws on recent advances in the ability to genetically modify and grow human red blood cells from stem cells in culture. (technologyreview.com)
  • To determine the effects of the presence of valproic acid (VA), Wharton's jelly mesenchymal stem cells (MSC) are seeded to the two scaffolds. (asme.org)
  • Wharton's jelly MSC are multipotent adult stem cells present in the umbilical cord and drawn from their matrix [1,2,3]. (asme.org)
  • Such studies will enable us to understand the effects of drugs such as valproic acid on stem cells and will aid in designing scaffolds for applications in nerve regeneration. (asme.org)
  • Accumulating data suggests that many human tumors are organized in cellular hierarchies initiated and maintained by a small population of self-renewing so called cancer stem cells. (lu.se)
  • This was first demonstrated in acute myeloid leukemia (AML) but during recent years, cancer stem cells have also been demonstrated in other cancer types. (lu.se)
  • Within the MAD for Cancer Program, a previously unexplored combination of strategies will be used to identify new cell surface markers on AML stem cells. (lu.se)
  • In work performed by Division of Translational Cancer Research it is shows that the hypoxic state pushes neuroblastoma and breast cancer towards an immature, stem cell-like phenotype. (lu.se)
  • Cells with high expression of HIF-2 α have properties rendering the tumors aggressive behavior potentially being the neuroblastoma tumor stem cells. (lu.se)
  • Anticipated to undergo 3 cycles of chemotherapy (solid tumour cancer participants) OR autologous stem cell transplantation (haematological cancers - HSCT participants). (who.int)
  • Haematopoeitic stem cell transplant (HSCT) recipients - from day of admission (~day -7) to day +35. (who.int)
  • However it remains unknown which endocytic pathways are active in brain endothelial cells. (helsinki.fi)
  • In present study we characterized human brain endothelial cells, hCMEC/D3, which are widely utilized as BBB in vitro model. (helsinki.fi)
  • As brain endothelial cells are polarized in vivo, the aim of the study was to demonstrate the cell polarization of hCMEC/D3 cells and to study the activity and functionality of different endocytic pathways as a function of cell polarization. (helsinki.fi)
  • RPT works by tagging a radionuclide to a drug-carrier that specifically targets tumor cells. (voximetry.com)
  • Some labile cell types whose numbers are normally or all severe infections that could be targets for pharmaco- controlled through programmed cell death are subject to logic intervention. (cdc.gov)
  • It is well known that the rapid growth of tumor cells and distortion of tumor blood vessels often results in insufficient oxygen supply and acidification in solid tumors. (nature.com)
  • These experiments temporally and molecularly separate two key stages in tumor cell entry into blood vessels: invasion and intravasation. (aacrjournals.org)
  • In human lung tumors, combined activation of K-RAS and inactivation of RASSF1A is closely associated with the development of the most aggressive and worst prognosis tumors. (cancerindex.org)
  • The epidermal growth factor receptor family (ERBB) is overexpressed in a wide variety of tumor types and is correlated with poor prognosis. (aacrjournals.org)
  • We have recently shown [1] that the integration of solid-state NMR with multi-scale molecular dynamics simulations gives access to high-resolution structures of supramolecular peptide-based drug vectors (Figure 2). (uu.nl)
  • It is known that arsenic trioxide (ATO) is able to inhibit the migration and invasion of solid malignant tumors, but its exact molecular mechanism remains unclear. (nih.gov)
  • Here, we report a novel molecular target and antimetastatic mechanism of ATO in head and neck squamous cell carcinoma (HNSCC). (nih.gov)
  • On the other hand active focusing on involves the attachment of a moiety such as a monoclonal antibody or a ligand to deliver a drug to pathological sites or to cross biological barriers based on molecular acknowledgement processes. (exposed-skin-care.net)
  • We publish articles in pharmaceutical sciences and related disciplines (including biotechnology, cell and molecular biology, drug utilization including adverse drug events, medical and other life sciences, and related engineering fields). (ajol.info)
  • Upon examination of the tumors, the researchers found minimal penetration of the dead bacterial cells and the beads into the tumor, whereas the live bacterial cells were found deep within the tumor and especially in regions with low oxygen content. (innovationtoronto.com)
  • They attached approximately 70 drug-containing vesicles to each bacterial cell. (innovationtoronto.com)
  • Here, we investigate oxidative degradation of a carbon nanotube -based drug carrier loaded with Doxorubicin. (cdc.gov)
  • Furthermore, they were able to kill tumor cells in vitro and to function as a drug carrier as they could be conjugated, via amide linkages, to the antitumor drug doxorubicin. (chemistryviews.org)
  • Doxorubicin (Dox) conjugated to MDC (MDC-Dox) showed higher cancer cell growth inhibition than MDC alone especially in cell lines with high EGFR expression. (johnshopkins.edu)
  • Of note, the TME is rich in immunosuppressive cells (e.g., tumor-associated macrophages (TAMs), regulatory T cells (Tregs), immature dendritic cells (iDCs) and myeloid-derived suppressor cells (MDSCs)), that can suppress antitumor immunity as a result of secretion of various cytokines and chemokines, which enables tumor escape from immune surveillance [ 8 ]. (thno.org)
  • Clinical studies using ERBB inhibitors have focused on tumor growth effects, but ERBBs can contribute to malignancy independent of their effects on tumor growth. (aacrjournals.org)
  • These results indicate that ERBB inhibition should be considered for blocking other tumor cell malignant properties besides growth. (aacrjournals.org)
  • Some strains of Clostridia, Bifidobacteria and Salmonella are capable to invade and colonize solid tumors, destroying tumor cells or at least reducing their growth rate. (vitares.org)
  • In a mouse melanoma model, MDC-Dox significantly suppressed tumor growth when compared with free Dox. (johnshopkins.edu)
  • ATO at non-cytotoxic level (1 μM) inhibited the migration and invasion of HNSCC cells by displacing zinc in the zinc finger motif of CLIP170, which is a key protein that controls microtubule dynamics. (nih.gov)
  • Rubius's first drug will be for phenylketonuria, or PKU, a devastating genetic disorder that renders people with the disease unable to digest the amino acid phenylalanine, which is found in most high-protein foods. (technologyreview.com)
  • It takes only a few weeks to grow cells that produce a new protein of interest-a process Kahvejian calls "rapid prototyping. (technologyreview.com)
  • On a different front, researchers have unraveled the mechanism of protein carbohydrate interactions among cells involved in the inflammation process. (drshrutibhat.com)
  • These include members of the Bcl-2 protein family, course, and extent of programmed cell death will aid man- which have both proapoptotic and antiapoptotic activity agement of patients with severe infections. (cdc.gov)
  • When incubated with immune cells, they stimulated the production of tumor necrosis factor α, a potent pro-inflammatory molecule. (chemistryviews.org)
  • Our studies were designed to evaluate the effect of ERBB inhibition on tumor cell motility and intravasation in vivo using clinically relevant small-molecule inhibitors. (aacrjournals.org)
  • Despite their efficiency, adoptive T-cell therapies show unique toxicities, which are distinct from those seen with conventional chemotherapies, monoclonal antibodies (mAbs), and small-molecule-targeted therapies. (nature.com)
  • This process allows these malignant cells to produce energy quickly. (wikipedia.org)
  • The drug moieties may affect cytotoxic and cytostatic mechanisms including tubulin binding, DNA binding, or topoisomerase inhibition. (justia.com)
  • The company has so far tested the PKU drug in animals and in human blood in the lab, and it aims to begin clinical testing next year. (technologyreview.com)
  • Optimal clinical outcome cannot be achieved if drug plasma concentrations are constant. (scialert.net)
  • In current clinical development, targeting CD19 + B cell malignancies, which include acute and chronic B-cell leukaemia and B-cell non-Hodgkin lymphomas (NHLs), with anti-CD19 CAR-T cells is one of the most advanced adoptive T-cell therapies and has been approved by the FDA. (nature.com)
  • Clinical cancer immunotherapies are usually impeded by tumor immunosuppression driven by tumor associated macrophages (TAMs). (thno.org)
  • Two experiments were performed on regular HEK-cells: inhibitor experiment with KYP-2047 (1 or 10 µM) and overexpression experiment (transfection with either active or inactive hPREP plasmid). (helsinki.fi)
  • Using in vivo mouse models of breast cancer, we test the effects of ERBB1 and ERBB2 inhibitors AC480 and lapatinib, ERBB1 inhibitor gefitinib, and ERBB2 inhibitor AG825 on in vivo tumor cell invasive properties in mammary fat pad tumors. (aacrjournals.org)
  • 7,8 Chloroquine, an United States Food and Drug Administration-approved inhibitor of autophagy, has been revealed to possess antitumor property for impairing mitochondrial metabolism. (rsc.org)
  • Oregon State University researchers have devised a way of sneaking a cancer drug vinblastine into solid tumors that would otherwise not be very welcoming of it. (medgadget.com)
  • The investigators used "prodrug" vinblastine-N-oxide, known in a low oxygen environments within the body, such as those within solid tumors, to turn into vinblastine. (medgadget.com)
  • AUC for solid tumour patients will be assessed over the 3rd full cycle of chemotherapy after starting medicinal cannabis. (who.int)
  • The hypothesis based on the fact that breast, colorectal and lung cancer cells produce unusually large amounts of receptor chemicals CD 44 and RHAMM- involved in initiating a cascade of events that lead to proliferation of both defense and cancer cells. (drshrutibhat.com)
  • Further research on its safety and ability to carry various anti-cancer drugs into multiple drug-resistant primary breast models is warranted. (johnshopkins.edu)
  • We have demonstrated that the synthesized PNC possesses weak toxic effects toward human leukemia cells (HL-60 and Jurkat lines), as well as toward hepatocellular (HepG2), colon (HCT116) and breast (MCF-7) tumor cell lines. (biomedcentral.com)
  • SCR-6852, an oral and highly brain-penetrating estrogen receptor degrader (SERD), effectively shrinks tumors both in intracranial and subcutaneous ER + breast cancer models. (medscape.com)
  • miR-203 drives breast cancer cell differentiation. (medscape.com)
  • Transformation of human breast epithelial cells by chemical carcinogens. (cdc.gov)
  • Inflammatory Drugs and Risk of Breast Cancer: Evidence from a General Female Population and a Mammographic Screening Cohort in Sweden. (cancercentrum.se)
  • Then we determined how long the nano carriers could keep the drug in the blood compared to the drug without the nanostructures. (medgadget.com)
  • Researchers at the Technical University of Munich (TUM), working together with the KTH Royal Institute of Technology in Stockholm, have developed a stable nano-carrier for medications. (tum.de)
  • In addition, they induce inflammation, which sustain tumor progression. (vitares.org)
  • Mitochondria play an important role in supplying cellular energy, cell signaling and governing cell death. (rsc.org)
  • Furthermore, ATO dysregulated microtubule polymerization via the CLIP170/LIS1/NDEL1/dynein signaling pathway in Cal27 cells as a functional consequence of CLIP170 zinc finger disruption. (nih.gov)
  • The level of cell polarization in cells grown on transwell permeable supports was characterized at multiple timepoints with four different methods: transepithelial electrical resistance (TEER) measurement, lucifer yellow permeability assay, alkaline phosphatase expression and ZO-1 expression. (helsinki.fi)
  • BACKGROUND Regorafenib (RGF) is the drug of choice for treating hepatic carcinoma (HCC), but the drug has drawbacks due to resistance and associated adverse effects. (cancerindex.org)
  • Drug resistance is a main obstacle for curative cancer chemotherapy. (hindawi.com)
  • resistance to antimicrobial drugs. (who.int)
  • Use additional code (U85) , if desired, to identify resistance, non-responsiveness and refractive properties of the neoplasm to antineoplastic drugs. (who.int)