• Cell cycle analysis suggested activation of apoptosis, without arresting cell cycle progression. (nature.com)
  • Annexin V-propidium iodide double-staining demonstrated that Sapota fruit extracts potentiate apoptosis rather than necrosis in cancer cells. (nature.com)
  • Loss of mitochondrial membrane potential, upregulation of proapoptotic proteins, activation of MCL-1, PARP-1 and Caspase 9 suggest that MESF treatment leads to activation of mitochondrial pathway of apoptosis. (nature.com)
  • SCARA5 overexpression significantly inhibited cell proliferation and induced apoptosis of CAL-27 and SCC-9 cells. (degruyter.com)
  • In conclusion, SCARA5 inhibited the proliferation and EMT and induced the apoptosis of OSCC cells through the inhibition of STAT3 and PI3K/AKT signaling pathways, thereby exerting a tumor suppressor effect. (degruyter.com)
  • To investigate the effect of gambogic acid (GA) on apoptosis in the HT-29 human colon cancer cell line. (wjgnet.com)
  • Cell apoptosis was detected by terminal deoxynucleotidyl transferase dUTP nick end labeling and Hoechst 33342 staining, and quantified by flow cytometry. (wjgnet.com)
  • Real-time cell analyzer and flow cytometry data reveal that tumor cell proliferation and apoptosis were impacted by FO. (hindawi.com)
  • DAVID bioinformatic data showed that most of the biological process GO terms are related to proliferation and apoptosis. (hindawi.com)
  • KEGG enrichment analysis showed that FO mainly regulates PI3K-AKT- and apoptosis-related signals, in which BBC3, DDIT3, NOXA, and CDKN1A on the surface serve as the novel targets of FO inducing HCC cell apoptosis. (hindawi.com)
  • The result implied that FO might exacerbate HCC cell apoptosis by regulating BBC3, DDIT3, CDKN1A, and NOXA signals. (hindawi.com)
  • N- trans -Feruloyloctopamine (FO) is the extract of garlic skin, which possesses high antioxidant activity and selectively induces cell apoptosis in leukemia tumors [ 6 ]. (hindawi.com)
  • We hypothesized that FO might regulate related genes in apoptosis and PI3K-AKT pathways to mediate the proliferation and apoptosis of liver cancer cells. (hindawi.com)
  • Cytotoxicity, antiproliferative and apoptosis-inducing capacity of ACNVs against hepatoma carcinoma cell were assessed. (dovepress.com)
  • ACNVs were found to possess specific antitumor cell proliferation activity associated with an apoptosis-inducing pathway. (dovepress.com)
  • Firstly, the overexpression of miRNA‑375 significantly suppressed cell proliferation, increased lactate dehydrogenase activity and induced apoptosis in HPV‑18(+) cervical cancer cells. (spandidos-publications.com)
  • It affects cell proliferation, differentiation and inhibits apoptosis, and its role in tumor development has received attention ( 9 ). (spandidos-publications.com)
  • Overexpression of IGF-1 in serum and tissue alters the growth of normal cells and causes uncontrolled proliferation, inhibits differentiation and reduces apoptosis, resulting in the incidence and development of malignant tumors ( 10 ). (spandidos-publications.com)
  • While knockout circIFT80 in HT29 cell or SW480 cells, the proliferation, and migration of the cells were inhibited, the cell cycle was arrested in G2/M phase, and the cell apoptosis was increased. (hindawi.com)
  • For example, circRNA_000166 can function as an oncogene by promoting the proliferation of CRC cells and by limiting apoptosis. (hindawi.com)
  • β -Catenin is a transcription factor that plays an important role in cell proliferation, cellular differentiation, apoptosis, and metastasis [ 10 ]. (hindawi.com)
  • Previous research has demonstrated that β -catenin can contribute to malignant progression and distant metastasis in CRC by promoting proliferation, limiting apoptosis, and accelerating epithelial-mesenchymal transition [ 11 , 12 ]. (hindawi.com)
  • CHAC2, downregulated in gastric and colorectal cancers, acted as a tumor suppressor inducing apoptosis and autophagy through unfolded protein response. (nih.gov)
  • Effects of valproic acid (VPA) and levetiracetam (LEV) on proliferation, apoptosis and hormone secretion of the human choriocarcinoma BeWo cell line. (aaem.pl)
  • Oncogenic mutations or abnormal expression of signaling components disrupt the regulatory networks that govern cell function, thus enabling tumor cells to undergo dysregulated mitogenesis, to resist apoptosis, and to promote invasion to neighboring tissues. (eurekaselect.com)
  • At high concentrations, NSAIDs have anticarcinogenic properties operating through cyclooxygenase-2-dependent and -independent pathways to inhibit cellular proliferation, inhibit angiogenesis, and induce apoptosis. (medscape.com)
  • p53 is a transcription factor that participates in cell cycle checkpoint processes and apoptosis. (lu.se)
  • Immunopathologic examination during infection showed cleavage of caspase 3 in brain cells adjacent to CD8+ cells and widespread p53 expression, hallmarks of apoptosis. (cdc.gov)
  • In nude mice xenografts, overexpressing ZNF452 also promoted tumor proliferation and metastasis. (oncotarget.com)
  • FAK plays a prominent role in tumor progression and metastasis regulating cellular processes including migration, invasion, epithelial to mesenchymal transition, and angiogenesis. (aacrjournals.org)
  • Colorectal cancer (CRC) is characterized by high rates of proliferation and metastasis and represents the third most common form of malignant tumor and the fourth leading cause of mortality in the world, thus creating a serious threat to health [ 1 ]. (hindawi.com)
  • circITGA7 serves as a tumor suppressor in CRC by inhibiting growth and metastasis by suppressing the Ras signaling pathway [ 8 ]. (hindawi.com)
  • Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis. (cdc.gov)
  • COX-2 inhibitors, which block the formation of prostaglandins, suppress tumor growth, whereas sEH inhibitors, which increase endogenous EETs, stimulate primary tumor growth and metastasis. (cdc.gov)
  • Using pharmacological inhibitors as probes, we show here that dual inhibition of COX-2 and sEH synergistically inhibits primary tumor growth and metastasis by suppressing tumor angiogenesis. (cdc.gov)
  • COX-2/sEH dual pharmacological inhibitors also potently suppress primary tumor growth and metastasis by inhibiting tumor angiogenesis via selective inhibition of endothelial cell proliferation. (cdc.gov)
  • Notably, cancer kills typically through metastasis, where the cancer cells acquire the capability to remodel their adhesions, generate forces and migrate to distant organs. (edu.au)
  • AXL significantly promotes tumour cell migration, invasion and metastasis, as well as angiogenesis. (cancerindex.org)
  • To evaluate the mechanisms underlying the role of AXL signalling in tumour metastasis, we screened a phage display library to generate a novel human monoclonal antibody, named DAXL-88, that recognizes both human and murine AXL. (cancerindex.org)
  • Dissemination of medulloblastoma within cerebrospinal fluid (CSF) pathways is a defining pathobiologic characteristic of this tumor, and about 30% of patients will have CSF metastasis at presentation. (medscape.com)
  • It activates transcription and contributes to proliferation, antiapoptosis, and metastasis of tumor cells ( 5 ). (iiarjournals.org)
  • The most frequent tumor suppressor miRs were miR-126, miR-199b and miR-22 and the hypoexpression of these miRs was associated with distant metastasis, worse prognosis and a higher risk of disease relapse (worse disease-free survival). (biorxiv.org)
  • Carcinoid tumors have high potential for metastasis. (medscape.com)
  • Overexpression of cyclophilins has been observed in HCC increasing proliferation, metastasis and promoting chemoresistance. (lu.se)
  • Caveolin-1 (Cav-1) is regarded as a major structural protein of caveolae and participated in lipid transport, signal transduction and tumor progression. (nih.gov)
  • Adipocyte-derived factors involved in tumor progression include proteins such as adiponectin, leptin, TNF-α, monocyte chemotactic protein-1 (MCP-1), IL-6, and ECM components that control tumor cell behavior within the tumor microenvironment. (jci.org)
  • 1 , 2 In recent years, mammalian cell-derived exosomes (a type of extracellular vesicle) have been widely used in the field of biomedicine, including diagnosis, regulation of disease progression and drug delivery. (dovepress.com)
  • Aggressive tumors typically demonstrate a high glycolytic rate, which results in resistance to radiation therapy and cancer progression via several molecular and physiologic mechanisms. (springer.com)
  • Furthermore, poorer prognosis in cancer patients who display a glycolytic phenotype characterized by metabolic alterations, such as obesity and diabetes, is now well established, providing another link between metabolic pathways and cancer progression. (springer.com)
  • In conclusion, our work reveals the impacts of circIFT80 as ceRNA in the progression of CRC, by which sponging miR-142, miR-568, and miR-634 enhanced the expression levels of β -catenin and activation Wnt/ β -catenin pathway. (hindawi.com)
  • The molecular biology underlying renal cell carcinoma (RCC) development and progression has been a key milestone in the management of this type of tumor. (cancerindex.org)
  • The most relevant articles summarising existing knowledge on RCC genomics, including tumour cell evolution and progression, were selected for this review. (springer.com)
  • It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. (thermofisher.com)
  • As a result, there is an emergent need to explore previously unmapped mechanisms regulating distinct subpopulations of tumor cells and to understand their contribution to tumor progression and treatment response. (lu.se)
  • Then, the inhibitory activity of lovastatin on cancer cells and tumoral xenografts, and the underlying mechanism involving in cell-cycle regulatory proteins were analyzed. (nih.gov)
  • These proteins act as tumour growth suppressors and regulate cell proliferation and differentiation. (wikipedia.org)
  • They found that inhibiting proteins in the Hedgehog network using drugs reduces growth of tumors in an animal model of human MEN1 syndrome. (medindia.net)
  • Cross-talk of the MAPK signaling pathway with other proteins and signaling pathways have a crucial impact on clinical outcomes of targeted therapies and plays important role during development of drug resistance in cancers. (mdpi.com)
  • In addition, numerous important cellular proteins, such as B-cell lymphoma-2 homologous antagonist/killer, Myc proto-oncogene protein, cyclin-dependent kinase inhibitor 1B, DNA replication licensing factor MCM-7, retinoblastoma 1 and Annexin A1, are degenerated through the UBE3A-mediated ubiquitin proteasome pathway ( 7 ). (spandidos-publications.com)
  • Cellular signaling pathways are networks of genes, proteins, enzymes, cytokines, and other cellular species that "communicate" in order to govern the basic functions of cells. (american.edu)
  • The Wnt signaling pathway creates a complex network of proteins that have different effects on cells, so they can be involved in many cancers, including gliomas. (researchsquare.com)
  • The Wnt signaling pathway creates a complex network of proteins that have different effects on cells. (researchsquare.com)
  • If this pathway is inactive, β-catenin levels will be kept lower by a set of proteins. (researchsquare.com)
  • When studying the LTD4 induced signalling pathways we found that CysLT1R mediated stress fibre formation and a calcium response through two heterotrimeric G-proteins, Ga12 and Gai3, respectively and that the LTD4 induced calcium response is dependent on PKCe. (lu.se)
  • Fibroblast growth factors (FGFs) are key regulators of cell proliferation, tumor-induced angiogenesis, and migration. (rcsb.org)
  • ETP augmented fibrosis, angiogenesis, and inflammation through recruitment of macrophages and endothelial cells. (jci.org)
  • Prostaglandins derived from the cyclooxygenase (COX) pathway and epoxyeicosatrienoic acids (EETs) from the cytochrome P450/soluble epoxide hydrolase (sEH) pathway are important eicosanoids that regulate angiogenesis and tumorigenesis. (cdc.gov)
  • Despite the SCAN N-terminus domain is known to play a role in transcriptional regulation of genes involved in cell survival and differentiation, there are no precise cellular functions that have been assigned to ZNF452. (oncotarget.com)
  • In addition to supplying cellular energy, mitochondria are involved in other tasks, such as signaling , cellular differentiation , and cell death , as well as maintaining control of the cell cycle and cell growth . (wikipedia.org)
  • We show that loss of Erk1/2 in intestinal epithelial cells results in defects in nutrient absorption, epithelial cell migration, and secretory cell differentiation," the authors wrote. (genengnews.com)
  • The oncogenic signaling pathway includes cellular species that regulate the growth, differentiation, and survival of cells. (american.edu)
  • The medulloblastoma has been defined by the World Health Organization (WHO) as a "malignant, invasive embryonal tumor of the cerebellum with preferential manifestation in children , predominantly neuronal differentiation, and inherent tendency to metastasize via CSF [cerebrospinal fluid] pathways. (medscape.com)
  • Cancer stem cells are a selective clonal subset of tumour cells that have avoided various cell regulatory mechanisms, including terminal differentiation, and yet have retained the self-renewal properties and proliferative potential of adult stem cells. (who.int)
  • Our previous report showed that FO inhibits HCC cell invasion via AKT-, mitogen-activated protein kinase- (MAPK-), and EMT-related signals [ 7 ]. (hindawi.com)
  • Parada-Turska J, Mitura A, Brzana W, Jablonski M, Majdan M, Rzeski W. Parthenolide inhibits proliferation of fibroblast-like synoviocytes in vitro. (aaem.pl)
  • However, the effect of triptolide on migration and invasion of human prostate cancer cells is still poorly understood. (nih.gov)
  • In this study, we demonstrated that triptolide significantly inhibited the proliferation, migration and invasion of prostate cancer cells in a time- and dose-dependent manner. (nih.gov)
  • Meanwhile, triptolide treatment combined with Cav-1 knockdown in PCa cells enhanced the effects of anti-migration and anti-invasion, and those effects were restored following Cav-1-rescued. (nih.gov)
  • Together, our research indicates that triptolide represses the migration and invasion through Cav-1/CD147/MMPs pathway in PCa cells, which gives a better understanding of triptolide in clinical aggressive prostate cancer therapy. (nih.gov)
  • ZNF452 facilitated tumor growth, colony formation, G1-S phase arrest, migration and invasion through upregulating the levels of CyclinD1, CyclinE1, p-Rb, or Snail, and downregulating the expression of Zo-1. (oncotarget.com)
  • This is also reflected in phenotypes of increased cell proliferation and migration. (frontiersin.org)
  • SOX9 promotes nasopharyngeal carcinoma cell proliferation, migration and invasion through BMP2 and mTOR signaling. (cancerindex.org)
  • Overexpression of SOX9 promoted NPC cell proliferation, migration and invasion. (cancerindex.org)
  • Next, the effects of miR-637 on glioma cell migration and invasion were determined by using the transwell assay. (scirp.org)
  • In addition, miR-637 suppressed glioma cell migration and invasion. (scirp.org)
  • Consequently, we aimed to assess miR-637 expression in gliomas to determine the effects of miR-637 on glioma cell migration and invasion, as well as to explore the possible signaling pathways involved. (scirp.org)
  • This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. (cancerindex.org)
  • A novel human anti-AXL monoclonal antibody attenuates tumour cell migration. (cancerindex.org)
  • Recent studies have revealed that AXL contributes to leukaemic phenotypes through activation of oncogenic signalling pathways that lead to increased cell migration and proliferation. (cancerindex.org)
  • Moreover, the Nogo-A-Δ20 domain promotes neuroblast migration toward the OB through activation of the Rho/ROCK (Rho-associated, coiled-coil containing protein kinase) pathway, without the participation of NgR1. (jneurosci.org)
  • Individuals with MEN1 are at a substantially increased risk of developing neuroendocrine tumors, including cancer of the pancreatic islet cells that secrete insulin. (medindia.net)
  • In recent years, however, theranostics has been successfully applied to a whole range of other malignancies, including neuroendocrine tumors (NETs) and prostate cancer in particular. (snmjournals.org)
  • Functional malignant cell heterogeneity in pancreatic neuroendocrine tumors revealed by targeting of PDGF-DD. (lu.se)
  • Here, making use of a newly generated Pdgfd knockout mouse, we reveal a functionally important malignant cell heterogeneity modulated by PDGF-DD signaling in pancreatic neuroendocrine tumors (PanNET). (lu.se)
  • Brien et al compared the characteristics of chondroblastoma of bone to chondroblastoma of soft tissue, giant cell tumor of the tendon sheath (GCTTS), and pigmented villonodular synovitis (PVNS). (medscape.com)
  • The number of mitochondria in a cell can vary widely by organism , tissue , and cell type. (wikipedia.org)
  • Collagen VI (COL6) is highly expressed in adipose tissue, upregulated in the obese state, and enriched in breast cancer lesions and is a stimulator of mammary tumor growth. (jci.org)
  • These effects were partially mediated through enhanced TGF-β signaling, which contributes to tissue fibrosis and epithelial-mesenchymal transition (EMT) of tumor cells. (jci.org)
  • Immunofluorescent staining of intestinal epithelium tissue shows cell growth (green). (genengnews.com)
  • The ERK pathway plays a critical role in embryonic development and tissue repair because it instructs cells to multiply and start dividing, but when overactivated cancer growth often occurs. (genengnews.com)
  • Integrative analyses reveal that pulmonary function instruments, including 73 novel variants, influence lung tissue gene expression and implicate immune-related pathways in mediating the observed effects on lung carcinogenesis. (nature.com)
  • We review the possible roles for calorie restriction (CR) and very low carbohydrate ketogenic diets (KDs) in modulating the five R's of radiotherapy to improve the therapeutic window between tumor control and normal tissue complication probability. (springer.com)
  • Inactivation of T cells limits damage to healthy tissue. (agilent.com)
  • Georgescu HI, Mendelow D, Evans CH. HIG-82: an established cell line from rabbit periarticular soft tissue, which retains the "activatable" phenotype. (aaem.pl)
  • Next, I will discuss how blood vessel cells interact mechano-chemically with each other to regulate the passage of cells and nutrients between blood and tissue, and how we model these interactions through a contact mechanics model. (edu.au)
  • Can we apply strategies used by extremophiles to improve mammalian cell and tissue storage? (researchgate.net)
  • The latter findings point to the participation of Nogo-A/NgR1 signaling in the regulation of other aspects of growth, such as tissue expansion or turnover by cell proliferation. (jneurosci.org)
  • Using the PubMed database, Cochrane Library and Web of Science, studies published in English evaluating miRs differentially expressed in tumor tissue and significantly associated with the prognostic aspects of CRC were selected. (biorxiv.org)
  • Specific tissue miRs are shown to be promising prognostic biomarkers in patients with CRC, given their strong association with the prognostic aspects of these tumors, however, new studies are necessary to establish the sensibility and specificity of the miRs in order to use them in clinical practice. (biorxiv.org)
  • [ 15 , 16 ] Although not expressed in normal urothelial tissue, cyclooxygenase-2 has been shown to be overexpressed in both transitional cell and squamous cell urothelial tumor tissue. (medscape.com)
  • Blocking CTLA-4 contributes to an increase in anti-tumor immune response. (agilent.com)
  • In this review article, different signaling pathways and how their dysregulation contributes to the development of tumors have been discussed. (eurekaselect.com)
  • Because FGF1 plays an important role in tumor formation, it is clear that preventing the formation of the multiprotein complex would be an effective strategy to inhibit a wide range of cancers. (rcsb.org)
  • The purpose of this study was to investigate whether breast cancer susceptibility gene 1 (BRCA1) overexpression sensitizes mammary cancer cells to statins. (nih.gov)
  • MCF-7 cells, which have only one wild-type BRCA1 allele, were transfected with pcDNA3-beta-HA-hsBRCA1 plasmids via liposomes to reconstitute BRCA1 overexpression human breast cancer cell line, and tumoral xenografts with BRCA1 overexpression were subsequently established in BALB/c nude mice. (nih.gov)
  • Our results suggest that BRCA1 overexpression sensitizes cancer cells to lovastatin via regulation of cyclin D1-CDK4-p21WAF1/CIP1 pathway, which will provide an innovative experimental framework to study control of breast cancer cell proliferation. (nih.gov)
  • Treatment of AKT inhibitor markedly prevented the phosphorylation of AKT and GSK3β which subsequently counteracted increasing expression of CyclinD1, CyclinE1 or Snail and restored the decreasing expression of Zo-1, as well as the upregulation of tumor proliferation and invasion, caused by ZNF452 overexpression. (oncotarget.com)
  • In addition, overexpression of SOX9 activated the mTOR pathway partly through BMP2. (cancerindex.org)
  • The overexpression of miRNA‑375 significantly increased caspase‑3 and caspase‑9 activities, induced B‑cell lymphoma 2 (Bcl‑2)/Bcl‑2‑associated X protein, tumor protein 53 and cyclin‑dependent kinase inhibitor 1 protein expression and suppressed cyclin D1 and survivin protein expression in HPV‑18(+) cervical cancer cells. (spandidos-publications.com)
  • The overexpression of miRNA‑375 significantly suppressed the levels of protein expression of ubiquitin‑protein ligase E3A (UBE3A) and Insulin‑like growth factor‑1 receptor (IGF‑1R) in HPV‑18(+) cervical cancer cells. (spandidos-publications.com)
  • Through simulations, Chifman and her collaborators found that overexpression of Ras, a central species in the oncogenic pathway, led to a cancer phenotype in the iron homeostasis pathway. (american.edu)
  • In this present study, we found that circIFT80 was abnormally overexpression in colorectal cancer tissues and tumor cells. (hindawi.com)
  • Cripto-1 overexpression in U87 glioblastoma cells activates MAPK, focal adhesion and ErbB pathways. (eurekaselect.com)
  • Cyclophilin overexpression is a common event in fibrotic tissues playing a key role in different stages of the fibrotic process, including inflammation, hepatocyte death, and activation of the hepatic stellate cells leading to increased collagen production. (lu.se)
  • We recently demonstrated that the Survival Associated Mitochondrial Melanoma Specific Oncogenic Non-coding RNA (SAMMSON) is essential for UM cell survi. (researchgate.net)
  • We could confirm the increased polyploidy upon Mps1 inhibition in neuroblastoma cell lines and PDX model, leading to mitotic catastrophe activating the caspase-dependent mitochondrial apoptotic pathway. (lu.se)
  • The intra- and intertumor heterogeneity of cell types and gene mutations as well as the complexity of the microenvironment contribute to limiting the efficacy of the current therapeutic options for high grade glioma. (mdpi.com)
  • Furthermore, the clear heterogeneity of CRC tumors indicates a clear need for new biological markers and therapeutic targets for CRC. (hindawi.com)
  • [ 1 ] These tumors display considerable clinical and biologic heterogeneity, and they have been further defined molecularly and histologically. (medscape.com)
  • Intra-tumour heterogeneity appears to hamper the clinical applicability of sparsely sampled tumours. (springer.com)
  • Most authors have not reported any significant difference in recurrence rates for tumors, regardless of the age or sex of the patient, the size of the lesion, the amount of calcification or vascular invasion seen on histologic examination, the duration of follow-up, or the method of treatment. (medscape.com)
  • If you block one pathway, cancer cells usually mutate and find another pathway that ultimately allows for a recurrence of cancer growth," remarked co-lead study author Koji Taniguchi, M.D., Ph.D., senior researcher at the Keio University School of Medicine in Tokyo. (genengnews.com)
  • TAM, however, does not appreciably reduce recurrence in most patients with ER-negative tumors ( 3 ). (iiarjournals.org)
  • Strikingly, contrary to its role as a tumor suppressor, excessive SETD2 results in the upregulation of cell cycle-associated pathways. (frontiersin.org)
  • An example is the YAP/TAZ signalling pathway that can activate in response to altered matrix mechanics and that can drive tumour phenotypes such as the rate of cell proliferation, or metastatic behaviour. (edu.au)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • In the present study, up-regulation of SOX9 was observed in both NPC tissues and different NPC cells. (cancerindex.org)
  • Egeblad M, Nakasone ES, Werb Z. Tumors as organs: complex tissues that interface with the entire organism. (eurekaselect.com)
  • The T category informs about tumor growth, depth and stage of adjacent tissues invasion. (biorxiv.org)
  • p53, mdm-2, p21, and mib-1 expression were assessed by immunohistochemical methods in primary tumors derived from 134 patients who took part in a randomized multicenter trial comparing docetaxel to sequential methotrexate and 5-fluorouracil (MF) in advanced breast cancer. (lu.se)
  • What's more, treating a mouse model of human MEN1 syndrome with a Hedgehog pathway inhibitor called Erivedge (FDA-approved in 2012 for metastatic or locally advanced basal cell carcinoma) reduced proliferation of tumor cells and blood insulin levels. (medindia.net)
  • Treatment of an high proliferative melanoma cell line with the Rock inhibitor Y27632 partially decreased the levels of P-FAKSer732, the cellular proliferation and impaired the mitotic spindle formation. (aacrjournals.org)
  • Targeting of the fibroblast activation protein is currently being explored for different tumor entities using PET imaging with the fibroblast activation protein inhibitor (FAPI) 68 Ga-FAPI-04, and the first therapeutic applications of 90 Y-FAPI-04 have been applied. (snmjournals.org)
  • Treatment with the novel cyclophilin inhibitor NV651, presented a potent antiproliferative effect in HCC cell lines via cell cycle perturbations arresting cells in the mitotic phase. (lu.se)
  • Subsequently, we found that the effect of ZNF452 on facilitating tumor proliferation and invasion was through activating its downstream AKT-GSK3β signaling pathway. (oncotarget.com)
  • Taken together we have shown that LTD4 might have an impact on tumour development through the regulation of CysLT1R and its downstream signalling pathways. (lu.se)
  • In response to DNA-damaging agents, the wild-type p53-activated fragment 1 (WAF1 also known as p21) is an important downstream effector in the p53-specific growth arrest pathway. (lu.se)
  • Gliomas are the most common primary brain tumors. (scirp.org)
  • [ 4 ] Adult cases are unusual, accounting for less than 1% of brain tumors. (medscape.com)
  • The finding of a novel role for FAK in tumor cells might provide the underpinning for therapeutic strategies in selected solid tumors. (aacrjournals.org)
  • These 2 theranostic approaches, as well as the therapy of osseous metastases of prostate cancer with 223 Ra ( 4 , 9 , 10 ), have unequivocally demonstrated that radionuclide therapy can be applied not only to thyroid cancer but also to other solid tumors. (snmjournals.org)
  • In this review, we summarize recent studies exploring how KSHV manipulates host cell metabolism to promote viral pathogenesis, which provides the potential therapeutic targets and strategies for KSHV-associated cancers. (frontiersin.org)
  • An international research team lead by scientists at the University of California San Diego School of Medicine uncovered some surprising results while investigating a potential therapeutic target for the ERK1 and two pathways. (genengnews.com)
  • they can also serve as potential biomarkers and therapeutic targets for tumors, as demonstrated in multiple studies [ 7 ]. (hindawi.com)
  • Long non-coding RNAs (lncRNAs) can exhibit cell-type and cancer-type specific expression profiles, making them highly attractive as therapeutic targets. (researchgate.net)
  • These results demonstrate a critical interaction of these two lipid metabolism pathways on tumorigenesis and suggest dual inhibition of COX-2 and sEH as a potential therapeutic strategy for cancer therapy. (cdc.gov)
  • Because the expression of the estrogen receptor (ER) in patients with primary breast cancer is one of the most powerful indicators of response to adjuvant hormonal therapy, the effects of endocrine-therapeutic agents strongly depend on whether tumor cell growth remains estrogen responsive ( 3 ). (iiarjournals.org)
  • Targeting the cell cycle has been proposed as a therapeutic strategy in cancer treatment with special interest in the mitotic phase. (lu.se)
  • In this scenario, the identification of molecular biomarkers of response and the use of a multimodal in vivo imaging approach represent unique tools for better understanding tumor features, with the final goal of identifying a cluster of patients that are potential responders to personalized medicine. (mdpi.com)
  • Laboratory diagnosis of carcinoid tumors depends on the identification of the characteristic biomarkers of the disease. (medscape.com)
  • Increasing evidence has shown that KSHV infection can alter central carbon metabolic pathways to produce biomass for viral replication, as well as the survival and proliferation of infected cells. (frontiersin.org)
  • Therefore, we investigated the combined effect of Temozolomide (TMZ) and KC7F2 on cell survival and changes in gene expression in the Wnt signal pathway. (researchsquare.com)
  • The survival of patients with CRC is directly associated with the pathological stage (pTNM) of the disease which is determined after microscope analysis of the sample obtained by biopsy or surgical resection of the tumor 2 , 3 . (biorxiv.org)
  • [ 17-20 ] In vitro and in vivo research suggests that NSAIDs and selective cyclooxygenase-2 inhibitors hinder growth and survival of bladder cancer cells and nitrosamine-induced tumors. (medscape.com)
  • This study uncovered a new layer of regulation of pro-proliferative genes by menin via the Hedgehog signaling pathway," Hua says. (medindia.net)
  • Screening with RNA-Seq in Huh7 cells treated with FO revealed that 317 genes were modulated, of which 188 genes were upregulated and 129 genes were downregulated. (hindawi.com)
  • Herein, genome-wide transcriptome profiling (RNA-Seq) was used to screen the differentially expressed genes (DEGs) in FO-treated Huh7 cells, with the aim of uncovering the pharmacologic pattern. (hindawi.com)
  • The expression of genes through miRNA is regulated by endogenous regulatory pathways, resulting in high stability and biocompatibility ( 5 ). (spandidos-publications.com)
  • Also, Quantitative RT-PCR was used to evaluate the mRNA expression level of genes related to the Wnt signal pathway in treated cancer cells and control groups. (researchsquare.com)
  • Candidate target genes were identified through Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis. (scirp.org)
  • We shall consider each subtype in turn describing genes and pathways of oncogenesis and how these relate to prognosis and treatment response. (springer.com)
  • To this end, we screen clinical tumor material for disease-causing mutations using deep sequencing technology and we manipulate genes of interest in cancer model systems to understand the true consequences of mutations. (lu.se)
  • The Von Hippel-Lindau ( VHL ) tumour suppressor gene undergoes bi-allelic knockout in the vast majority of clear cell RCCs. (springer.com)
  • Researchers still did not exactly understand how menin mutations lead to MEN1 syndrome, and more importantly, what molecular pathways might be dysregulated by menin mutations and thus can be targeted to improve therapy against this type of cancer. (medindia.net)
  • Menin mutations lead to increased Hedgehog signaling and cell proliferation. (medindia.net)
  • But other times, as in this case, the tumor does not need to develop mutations to find an escape route from targeted therapy. (genengnews.com)
  • Mutations in the CACNA1D gene have been found to cause aldosterone-producing adenomas, which are noncancerous (benign) tumors that form in the adrenal glands. (medlineplus.gov)
  • The genetic changes involved in these tumors, called somatic mutations, are acquired during a person's lifetime and are present only in adrenal gland cells that give rise to the tumors. (medlineplus.gov)
  • Unlike the mutations that cause aldosterone-producing adenomas (described above), the mutations that cause these conditions are present in essentially every cell in the body. (medlineplus.gov)
  • Inherited mutations that increase the flow of calcium into cells have been identified in individuals with a condition called primary aldosteronism, seizures, and neurological abnormalities (PASNA). (medlineplus.gov)
  • These mutations likely impair the CaV1.3 channel's function in inner ear cells, impairing hearing, and in the cluster of cells in the heart that acts as the heart's natural pacemaker (the sinoatrial node), leading to abnormal heart rhythms. (medlineplus.gov)
  • Scientists have identified that pancreatic cancer cells growth and spread are fueled by an unusual metabolic pathway that someday might be blocked with targeted drugs to control the deadly cancer. (medindia.net)
  • These signaling pathways are widely expressed and known to drive cancer growth in one-third of patients with colorectal cancer (CRC). (genengnews.com)
  • Colorectal cancer (CRC) is the third most common form of malignant tumor and is characterized by high rates of proliferation and metastases. (hindawi.com)
  • The etiology of carcinoid tumors is not known, but genetic abnormalities are suspected. (medscape.com)
  • Thus, Julia Chifman's research aims to understand the cause of iron dysregulation in breast cancer through the study of certain cellular signaling pathways that affect iron homeostasis. (american.edu)
  • Assistant Professor of Mathematics and Statistics Julia Chifman and her collaborators built a predictive mathematical model that connects four key cytosolic cellular signaling pathways in breast epithelial cells: the oncogenic pathway, the oxidative stress response pathway, the iron utilization pathway, and the iron homeostasis pathway. (american.edu)
  • Cancer cell biology takes advantage of identifying diverse cellular signaling pathways that are disrupted in cancer. (eurekaselect.com)
  • More importantly, we show that MESF treatment leads to significant inhibition of tumor growth and a 3-fold increase in the life span of tumor bearing animals compared to untreated tumor mice. (nature.com)
  • Here we show that methanolic extracts of Sapota fruit (MESF) induces cytotoxicity in a dose-dependent manner in cancer cell lines. (nature.com)
  • Carbamazepine induces mitotic arrest in mammalian Vero cells. (aaem.pl)
  • The effects of TMZ and KC7F2 on cancer cell viability and proliferation were investigated by WST-1 method. (researchsquare.com)
  • The presented study investigates the effect of anti-epileptic drugs on the viability and proliferation of synovial fibroblasts in vitro . (aaem.pl)
  • Mib-1 monoclonal antibody recognizes the proliferation-related antigen Ki-67. (lu.se)
  • Гістіоцитоз легеневих клітин Лангерганса Pulmonary Langerhans cell histiocytosis (PLCH) is proliferation of monoclonal Langerhans cells in lung interstitium and airspaces. (msdmanuals.com)
  • Kaposi's sarcoma-associated herpesvirus (KSHV), a human oncogenic herpesvirus, is tightly associated with several human malignancies by infecting B-lymphocyte or endothelial cells. (frontiersin.org)
  • In vivo antitumor activity and toxicity were evaluated in Hep G2 cell xenograft model. (dovepress.com)
  • In addition, xenograft tumor experiments showed that circIFT80 accelerated the tumorigenesis of CRC in vivo. (hindawi.com)
  • In addition, NV651 decreased tumour growth in xenograft-mouse model. (lu.se)
  • However, intestinal epithelial cell proliferation is not impeded, implying compensatory mechanisms. (genengnews.com)
  • In 2016 alone, an estimated 134,490 new cases are expected to be diagnosed, so understanding the molecular mechanisms that drive tumor promotion are paramount to treating this disease effectively. (genengnews.com)
  • However, the regulatory mechanisms of HPV infection and consequent immune escape reaction, persistent infection and cell proliferation and the regulatory mechanisms of vascular proliferation are poorly understood and require additional investigation ( 4 ). (spandidos-publications.com)
  • Intriguingly, many of these mechanisms utilize the same molecular pathways that are altered through calorie and/or carbohydrate restriction. (springer.com)
  • The objective of this study was to assess the underlying mechanisms of mango polyphenol decreased cell proliferation and tumor volume in ductal carcinoma in situ breast cancer. (oregonstate.edu)
  • The alcohol influence on epigenetic mechanisms leads to molecular adaptation of a wide number of brain circuits, including the hypothalamus-hypophysis-adrenal axis, the prefrontal cortex, the mesolimbic-dopamine pathways and the endogenous opioid pathways. (bvsalud.org)
  • Although highly preliminary, the findings suggest that different tumor biological factors may predict response to different chemotherapy regimens with distinct mechanisms of action. (lu.se)
  • Previously, we reported that anti-rheumatic drugs, both COX inhibitors and disease-modifying anti-rheumatic drugs inhibit proliferation of synoviocytes in vitro . (aaem.pl)
  • These results suggest that mango polyphenols and their major microbial metabolite, pyrogallol, inhibit proliferation of breast cancer cells through ROS-dependent up-regulation of AMPK and down-regulation of the AKT/mTOR pathway. (oregonstate.edu)
  • Genetic deletion of Erk1/2 or pharmacological targeting of MEK1/2 results in supraphysiological activity of the ERK5 pathway. (genengnews.com)
  • Hypoxia and genetic defects that chronically drive proliferation leave such tumors dependent on a steady supply of nutrients, especially glucose. (springer.com)
  • In this review, we consider what is currently known of the genetic landscape of the commonest subtypes of renal cell cancer (RCC). (springer.com)
  • This offers one of the most challenging paradoxes in cancer biology: what is required of a cell to not only survive massive genetic damage but also outcompete neighboring cells and present as a malignant tumor? (lu.se)
  • The fibroblast-like synovial cell in rheumatoid arthritis: a key player in inflammation and joint destruction. (aaem.pl)
  • 2012) . Sterile inflammation associat- The key mechanistic pathways and vation of inflammatory cel s (Balkwill, ed with inhalation of crystal ine silica mediators involved in inflamma- 2012 ). (who.int)
  • Cancer cells often rewire metabolic pathways to balance ATP production for supporting rapidly tumor proliferation. (frontiersin.org)
  • Figure 1 Brief schematics of KSHV-mediated alteration of host cellular metabolic pathways. (frontiersin.org)
  • The key steps of three cellular metabolic pathways including aerobic glycolysis, glutaminolysis and fatty acid synthesis targeted by KSHV for pathogenesis are highlighted. (frontiersin.org)
  • It is mutated in a variety of cancers and is believed to be a tumor suppressor. (frontiersin.org)
  • The most common non-clear cell renal cancers have also undergone genomic profiling and are characterised by distinct genomic landscapes. (springer.com)
  • Correlation with outcome needs to be more comprehensively furnished, particularly for small renal masses, rarer non-clear cell renal cancers, and for all tumours undergoing targeted therapy. (springer.com)
  • Deaths from sporadic cancers (i.e. cancers for which no recognized exposure accounts for tumour development) may be prevented by screening or earlier diagnosis. (who.int)
  • The GAS1 protein promotes Hedgehog signaling, and thus by inhibiting Gas1 expression, menin and PRMT5 effectively dial down the pathway's tendency towards cell proliferation. (medindia.net)
  • Our results highlight the crucial role of ETP as an obesity-associated factor that promotes tumor growth in the context of adipocyte interactions with tumor and stromal cells. (jci.org)
  • HPV promotes latency and consequently does not cause a disease phenotype following initial infection by an immune evasion response reaction, featuring binding to epithelial cells and integrating into the host genome, resulting in the proliferation of epidermal cells containing the viral genome and neovascularization ( 3 ). (spandidos-publications.com)
  • Overactivation of the calcium/calmodulin pathway in the adrenal glands also increases cell growth and division (proliferation), which promotes adenoma formation. (medlineplus.gov)
  • A chondroblastoma is a rare, usually benign, tumor of bone that accounts for approximately 1% of all bone tumors. (medscape.com)
  • [ 1 ] A decade later, Jaffe and Lichtenstein renamed the Codman tumor a benign chondroblastoma to emphasize the chondroblastic genesis of the lesion and to distinguish it from the classic giant cell tumor of bone . (medscape.com)
  • [ 7 ] Sjögren et al performed cytogenetic analysis of benign and malignant cartilage tumors, and although no consistent karyotypic abnormalities were oberved, there were recurrent breakpoints seen at 2q35, 3q21-23, and 18q21. (medscape.com)
  • Moreover, ETP expression was associated with aggressive mammary tumor growth and high metastatic growth. (jci.org)
  • Mendelian randomization analyses demonstrate that reduced FEV 1 increases squamous cell carcinoma risk (odds ratio (OR) = 1.51, 95% confidence intervals: 1.21-1.88), while reduced FEV 1 /FVC increases the risk of adenocarcinoma (OR = 1.17, 1.01-1.35) and lung cancer in never smokers (OR = 1.56, 1.05-2.30). (nature.com)
  • Cerebrospinal fluid analyses over time demonstrated increasing protein concentrations and cell counts, paralleled by pathologic lactate elevations in all patients. (cdc.gov)
  • We focus on the characterization of the central nervous system (CNS) immunologic response to VSBV-1 by IHC analyses of immune cells in the brain of all patients, as well as by examination of cerebrospinal fluid (CSF) reactions over time during the disease. (cdc.gov)
  • Our analyses demonstrate that tumor growth was delayed in the absence of signaling by PDGF-DD. (lu.se)
  • ZNF452 facilitates tumor proliferation and invasion via activating AKT-GSK3β signaling pathway and predicts poor prognosis of non-small cell lung cancer. (oncotarget.com)
  • In a preliminary study it has been shown that phenolic antioxidants such as methyl 4- O -galloylchlorogenate and 4- O -galloylchlorogenic acid derived from Sapota fruits can induce cytotoxicity in colon cancer cells 23 . (nature.com)
  • A research team led by Xianxin Hua, MD, PhD, associate professor of Cancer Biology at the Abramson Family Cancer Research Institute, report in Cancer Research that menin suppresses signaling in the much-studied Hedgehog pathway in endocrine organs. (medindia.net)
  • Targeted inhibition of individual kinases of the MAPK signaling pathway using synthetic compounds represents a promising way to effective anti-cancer therapy. (mdpi.com)
  • Cancer cell energy metabolism is mainly dominated by three pathways of central carbon metabolism, including aerobic glycolysis, glutaminolysis, and fatty acid synthesis. (frontiersin.org)
  • For producing energy sufficient to maintain cancer cell proliferation, glutaminolysis is also often elevated in most of cancer cells. (frontiersin.org)
  • Thus, the metabolic plasticity of cancer cells is essential to generate energy required for cell proliferation. (frontiersin.org)
  • FAK is identified as a key mediator of signaling by integrins, the major family of cell surface receptors for extracellular matrix, as well as by other receptors in both normal and cancer cells. (aacrjournals.org)
  • To conclude, it was identified that the probable anti‑CA mechanism of miRNA‑375 modulates HPV through the UBE3A and IGF‑1R pathway in cervical cancer cells. (spandidos-publications.com)
  • UBE3A is associated with cervical cancer and may combine with the E6 proto-oncogene encoded by HPV16 within cervical cancer cells to form the E6/E6-AP protein complex through the ubiquitin proteasome pathway ( 4 ). (spandidos-publications.com)
  • Previous studies have identified that UBE3A exhibits abnormal expression in numerous tumor cells, including prostate, cervical and breast cancer ( 6 , 7 ). (spandidos-publications.com)
  • The results show that the combination of TMZ and KC7F2 can be a promising anti-cancer agent for the treatment of glioblastoma through the Wnt / β-catenin signaling pathway. (researchsquare.com)
  • However, the functional interactions of these two pathways in cancer are unknown. (cdc.gov)
  • Enhancement of HER-2 degradation by carbamazepine in breast cancer SKBR-3 cell line]. (aaem.pl)
  • Polyphenolics from mango (Mangifera indica L.) suppress breast cancer ductal carcinoma in situ proliferation through activation of AMPK pathway and suppression of mTOR in athymic nude mice. (oregonstate.edu)
  • Clear cell renal cell carcinoma (ccRCC) is the seventh most frequently diagnosed tumor in adults in Europe and represents approximately 2.5% of cancer deaths. (cancerindex.org)
  • Materials and Methods: aRNA was synthesized from 27 breast cancer tumors. (iiarjournals.org)
  • We selected the ERGs for this study from our previously developed custom-made breast cancer cell cDNA glass array ( 6 ). (iiarjournals.org)
  • Here we investigated whether a custom 3D microarray of 36 ERGs could classify a set of breast cancer tumors. (iiarjournals.org)
  • Shifting the equilibrium in cancer immunoediting: from tumor tolerance to eradication. (eurekaselect.com)
  • Deregulation of cell signaling in cancer. (eurekaselect.com)
  • Cell signaling and cancer. (eurekaselect.com)
  • Clear cell, papillary cell, and chromophobe renal cell carcinomas (RCCs) have now been well characterised thanks to large collaborative projects such as The Cancer Genome Atlas (TCGA). (springer.com)
  • The pTNM stage is a system of stage classification proposed by the American Joint Committee on Cancer which determines the degree of tumor development according with the T, N and M categories. (biorxiv.org)
  • We therefore chose to study CysLT1 in colon cancer specimens and in non-transformed and colon cancer cell lines. (lu.se)
  • Extracellular signal-regulated kinase (ERK) is a part of the mitogen-activated protein kinase (MAPK) signaling pathway which allows the transduction of various cellular signals to final effectors and regulation of elementary cellular processes. (mdpi.com)
  • Oral squamous cell carcinoma (OSCC) is a common tumor in the world. (degruyter.com)
  • Now, researchers at the Perelman School of Medicine at the University of Pennsylvania have found that pathway, which may lead to a new treatment for patients with MEN1 and sporadic endocrine tumors. (medindia.net)
  • In addition to locally aggressive behavior with fourth ventricular obstruction and hydrocephalus, medulloblastomas can metastasize via cerebrospinal fluid (CSF) pathways. (medscape.com)
  • moreover, normal cell regulation can be disrupted by tumor-suppressive or oncogenic miRNAs. (scirp.org)
  • We discuss cross-talk of the MAPK/ERK signaling pathway with other signaling pathways, in particular interplay with the Hippo/MST pathway. (mdpi.com)