Tumor human plasminogen plasminogen activator inhibitor 1. Medical search. Frequent questions

Classical polarization is usually associated with a proinflammatory response, including the increased production of tumor necrosis factor (TNF)-α, IL-1, and IL-6. (haematologica.org)
Produzione di tumor necrosis factor alfa interleuchina 6 e beta 2-microglobulina in corso di dialisi ad alti flussi. (unifg.it)
The expression of tumour necrosis factor (TNF)-α, interleukin (IL)-6, zonula occludens (ZO)-1, Beclin-1 and autophagy-related (atg) 5 mRNA was evaluated by quantitative PCR, and the expression of ZO-1, microtubule-associated proteins 1A/1B light chain 3B (LC3B) I and, LC3B II protein by Western blot. (karger.com)
Peritoneal injury initiates a proinflammatory response with the release of cytokines such as tumor necrosis factor-α interleukin-1 interleukin-6 and transforming growth factor-β1 (TGF-β1).8-12 studies using human mesothelial cells 12 have shown that these proinflammatory cytokines individually and synergistically stimulate the production of plasminogen activator inhibitor-1 (PAI-1) and reduce the synthesis of tissue plasminogen activator (tPA). (researchtoactionforum.org)
Interestingly, whole blood showed similar gene expression induction of macrophage-inflammatory protein-2 (MIP-2) and tumor necrosis factor alpha (TNFá) following LPS by pharyngeal aspiration or IP injection. (cdc.gov)

Among the proteolytic enzyme systems mixed up in degradation of extracellular matrix during tumor development invasion and metastasis may be the urokinase-type plasminogen activator (uPA) program. (tam-receptor.com)
10 11 The hypothesis of a causal part of uPA-catalyzed plasminogen activation and plasmin proteolytic activity in main tumor growth local invasion and/or metastasis was recently strongly supported by studies with tumors growing on mice with targeted disruption of the uPA or plasminogen genes 3 including a study having a genetically induced mammary carcinoma. (tam-receptor.com)
RAF265 A high level of PAI-1 expression by human or murine cancer cells growing on nude mice was reported to be associated with impairment of tumor growth invasion and/or metastasis. (tam-receptor.com)
22 Overexpression of PAI-1 by transgenic hosts did not affect the growth or metastasis of a transplanted murine melanoma. (tam-receptor.com)
23 In work with PAI-1 gene-deficient mice transplanted murine transformed keratinocytes needed host PAI-1 for tumor invasion and vascularization 24 25 whereas a genetically induced mammary carcinoma was unaffected by PAI-1 gene deficiency with respect to tumor growth vascularization and metastasis. (tam-receptor.com)
Epithelial-mesenchymal transition (EMT) is important for tumour cell invasion and metastasis and is a feature of aggressive carcinomas. (bvsalud.org)
Vascular endothelial cells also play a key role in cancer by limiting the access of circulating cells to sub-endothelial space and thereby reducing tumor metastasis. (oxfordbiomed.com)
This promotes neutrophil trafficking to cancerous lesions and primes these immune cells towards a pro-tumorigenic phenotype, thus supporting tumor growth and metastasis. (bmj.com)
Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. (academicinfluence.com)
Also, proteolysis is found in pathological conditions such as tumor growth, metastasis, arthritis and autoimmune diseases ( 1 ). (ispub.com)
In conclusion, present study revealed that DEGs are directly involved in of breast tumor metastasis in bone tissues. (degruyter.com)
A growing number of data confirming an important role of the fibrinolytic system in tumor progression and metastasis has been reported. (czytelniamedyczna.pl)

Urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor type-1 (PAI-1) have been validated at the highest level of evidence as clinical biomarkers of prognosis in breast cancer. (jcancer.org)
Background High tumor levels of urokinase-type plasminogen activator (uPA)-plasminogen activator inhibitor-1 (PAI-1) heteromers independently predict poor survival in early breast cancer. (bmj.com)

TGF-beta and immune cells: an important regulatory axis in the tumor microenvironment and progression. (academicinfluence.com)
The microenvironment is fundamental in attracting tumor cells to the bone as well as promoting tumor progression. (degruyter.com)
The composition of the tumor microenvironment changes during tumor development, evolving to meet the demands of the growing neoplasm [ 6 ]. (degruyter.com)
In addition, obesity is associated with progression (but not incidence) of tumour microenvironment through prostate cancer. (who.int)

It plays a major role in many processes such as angiogenesis, tumor invasion, and obesity. (rndsystems.com)
The objective of this study was to assess the individual protein expression and co-expression of Twist, Slug (Snai2), Snail (Snai1), and hypoxia-inducible factor-1 alpha (Hif-1α) in prostate cancer in relation to EMT, angiogenesis, hypoxia, tumour features, disease recurrence, and patient survival. (bvsalud.org)
To conclude, we demonstrate an important relation between EMT, hypoxia, and angiogenesis and a strong link between the investigated EMT regulators and aggressive tumour features and poor patient outcome in prostate cancer. (bvsalud.org)
Despite the retrospective nature of this long-term study, our findings could have a significant impact on the future treatment of prostate cancer, where tailored therapies might be directed simultaneously against epithelial-mesenchymal phenotypes, angiogenesis, and tumour hypoxia. (bvsalud.org)
Novel cancer treatment strategies take advantage of tumor-induced vascularisation by combining standard chemotherapeutic agents with angiogenesis-inhibiting agents. (biomedcentral.com)
We postulated that the expression levels of angiogenesis-related proteins from various primary tumor cultures would be greater under hypoxic conditions than under normoxia. (biomedcentral.com)

Plasminogen activator inhibitor-2 (placental PAI, SerpinB2, PAI-2), a serine protease inhibitor of the serpin superfamily, is a coagulation factor that inactivates tissue plasminogen activator and urokinase. (wikipedia.org)
De- cidual cells promote hemostasis through enhanced expression of tissue factor (TF), the primary initiator of hemostasis via thrombin generation, and plasminogen activator inhibitor-1, which inactivates tissue type plasminogen activator, the primary fibrinolytic agent. (scirp.org)

Using ultrastructural and confocal laser scanning microscopic (CLSM) image analysis, we observed that treatment of Dami cells, a human megakaryocytic cell line, with phorbol myristate acetate (PMA) induces the accumulation of PAI-1 and Vn in intracellular storage vacuoles that contain other alpha-granule proteins such as von Willebrand factor. (mcmaster.ca)
This is the first study describing the production and distribution of ETS-1 and ETS-2 mRNAs and proteins using in situ hybridization and immunohistochemistry in murine ocular tissue sections of normal control eyes and tumoral eyes from mice of the same age. (molvis.org)
Emerging risk factors for CVD include isoprostanes, C-reactive proteins, fibrinogen and plasminogen activator inhibitor 1 (PAI-1). (oxfordbiomed.com)
Results Here, we demonstrate that uPA-PAI-1 heteromerization multiplies the potential of the single proteins to attract pro-tumorigenic neutrophils. (bmj.com)

Reverse transcription-PCR analysis of RNA extracted from resting and PMA-treated Dami cells confirmed that PAI-1 mRNA expression was detectable at low levels in resting cells and induced by PMA treatment. (mcmaster.ca)
In immunohistochemistry the staining design obtained using the antibodies demonstrated a good relationship using the PAI-1 mRNA appearance pattern. (tam-receptor.com)
ETS-1 and ETS-2 mRNA and protein levels were much higher in the ocular tissues of Tyrp-1-TAg mice than in control ocular tissues from wild-type mice. (molvis.org)
It lifts the mRNA levels of plasminogen activator (PA) and plasminogen activator inhibitor (PAI) to play a role of activation and regulation on PA and PAI-1, thus enhancing the activity of plasminogen activator and promoting the formation of new capillaries. (spandidos-publications.com)
4 ) found that uPA mRNA seems to be up-regulated in endometriotic glands and endometrial stroma as well as PAI-1 mRNA in endometriotic and endometrial stroma from women with endometriosis. (ispub.com)
TNF‑α significantly promoted TF and PAI‑1 expression either at the mRNA or protein level in AECII cells. (spandidos-publications.com)

In a concentration-dependent manner urokinase or thrombin abrogated the inhibitory effect of PAI-1. (regsj.dk)
They are distinguished from INDIRECT THROMBIN INHIBITORS, such as HEPARIN, which act by enhancing the inhibitory effects of antithrombins. (lookformedical.com)
Abruptions (decidual hemorrhage) produce excess thrombin which acts as autocrine/paracrine inducer of decidual cell expressed matrix metalloproteinases and of neutrophil chemoattractant and activator, interleukin-8. (scirp.org)
2009) Progestin and thrombin regulate tissue factor expression in human term decidual cells. (scirp.org)

uPA/PAI-1 expression and neutrophil infiltration in human breast cancer samples were assessed by RNA sequencing, immunhistochemistry, and ELISA. (bmj.com)

The sole validated method for quantifying uPA and PAI-1 levels in breast tumor tissue is a colorimetric ELISA assay that takes 3 days to complete and requires 100-300 mg of fresh or frozen tissue. (jcancer.org)
In this study we describe a new assay method for quantifying PAI-1 levels in human breast tumor tissue. (jcancer.org)
This assay combines pressure-cycling technology to extract PAI-1 from breast tumor tissue with a highly sensitive liposome polymerase chain reaction immunoassay for quantification of PAI-1 in the tissue extract. (jcancer.org)

Although histone deacetylase (HDAC) inhibitors are known to suppress synovial sarcoma in vitro and in vivo , the exact mechanism is not clear. (nature.com)
In vitro, defibrotide increased tissue plasminogen activator (t-PA) and thrombomodulin expression and decreased von Willebrand factor (vWF) and plasminogen activator inhibitor-1 (PAI-1) expression, thereby reducing EC activation and increasing EC-mediated fibrinolysis. (medscape.com)

Pulmonary inflammation can damage pulmonary vascular endothelial cells and type-II alveolar epithelial cells (AECII), which further increases the expression of tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) in these cells, thus activating the exogenous coagulation system. (spandidos-publications.com)

In several tumor types, SERPINE1 expression is up-regulated and it has been described as a poor prognostic marker. (ptglab.com)

Blockade of uPA-PAI-1 heteromerization by a novel inhibitor effectively interfered with these events and prevented tumor progression. (bmj.com)

SERPINE1, also named as Plasminogen activator inhibitor type 1 (PAI-1), is a member of the serine protease inhibitor (SERPIN) superfamily. (ptglab.com)

Influence of the 4G/5G polymorphism of plasminogen activator inhibitor-1 gene in acute unprovoked deep vein thrombosis and residual vein thrombosis. (cdc.gov)

Serpin E1, also known as Plasminogen Activator Inhibitor-1 (PAI-1), is the principal inhibitor of urokinase-type and tissue-type plasminogen activators. (rndsystems.com)
7 The principal inhibitor of uPA RAF265 may be the serpin plasminogen activator inhibitor-1 (PAI-1). (tam-receptor.com)

PAI-2 uses a suicide inhibition mechanism (a common mechanism for serpins) to irreversibly inactivate tissue plasminogen activator and urokinase. (wikipedia.org)
18-20 Injections of PAI-1 protein into immunodeficient mice bearing transplanted human tumors led to either inhibition of tumor growth 21 or stimulation of tumor growth at low PAI-1 level injected and inhibition of tumor growth at high PAI-1 level injected. (tam-receptor.com)
The close proximity of binding sites for alpha(v)-integrins and plasminogen activator inhibitor-1 (PAI-1) on vitronectin may have consequences for cell adhesion and migration, or for the localized inhibition of plasminogen activators. (regsj.dk)
These data were supported by experiments in a purified system where delayed addition of active PAI-1 could no longer prevent vitronectin binding to immobilized alpha(v)beta3, while a cyclic RGD peptide gave some moderate inhibition. (regsj.dk)
1998). p21(WAF1) is required for butyrate-mediated growth inhibition of human colon cancer cells. (nature.com)
2004). Inhibition of cell growth by EGR-1 in human primary cultures from malignant glioma. (nature.com)
Reversible inhibition of normal human prokeratinocyte proliferation by type beta transforming growth factor-growth inhibitor in serum-free medium. (academicinfluence.com)
A family of serine proteinase inhibitors which are similar in amino acid sequence and mechanism of inhibition, but differ in their specificity toward proteolytic enzymes. (lookformedical.com)
Hypercoagulability and fibrinolytic inhibition, either systemic or in lung tissue, are important characteristics of acute respiratory distress syndrome (ARDS) ( 1-4 ). (spandidos-publications.com)

Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. (ptglab.com)
Membrane-bound form of monocyte chemoattractant protein-1 enhances antitumor effects of suicide gene therapy in a model of hepatocellular carcinoma. (kanazawa-u.ac.jp)
Using semi-quantitative reverse-transcription polymerase chain reaction (RT-PCR) and western blots experiments, we compared changes in ETS-1 and ETS-2 expression, their protein levels, and the regulation of some of their target gene expressions at different stages of the ocular tumoral progression in the transgenic mouse model, Tyrp-1-TAg, with those in normal eyes from control mice of the same age. (molvis.org)
We further examined associations with type 2 diabetes and coronary artery disease, assessed the functional significance of the SNPs for gene expression in human tissues, and conducted RNA-silencing experiments for one novel association. (ox.ac.uk)
These results suggest that IL-6 stimulated PA activity through an enhancement of tPA gene expression and may be involved in extracellular matrix degradation through the stimulation of the PA-plasmin system of human dental pulp (HDP) cells ( 7 ). (ispub.com)
Many genes go to battle when they sense an infection that is trying to replicate, but the one that stood out above all the rest was SERPINE1, the gene that codes for PAI-1. (carbomer.com)
Our previous studies indicated that knockdown of the p65 gene or IKKβ inhibited lipopolysaccharide (LPS)-induced upregulation of TF and PAI-1 in rat AECII ( 15 , 16 ), indicating that the NF-κB signaling pathway participates in coagulation and fibrinolysis regulation in LPS-treated AECⅡ cells. (spandidos-publications.com)
Neither TF nor PAI-1 gene expression was elevated in blood following IP LPS although PAI-1 was strongly induced in the heart and lung. (cdc.gov)

Double-immunofluorescence analyses demonstrated co-expression of PAI-1 and α-even muscles actin in these cells recommending they are myofibroblasts. (tam-receptor.com)
Strong expression of Twist and Slug was associated with Hif-1α in localised prostate cancer (p ≤ 0.001), and strong Twist was associated with Hif-1α in castration-resistant carcinomas (p = 0.044). (bvsalud.org)
Although no apparent morphologic changes were observed, the B[a]P-exposed A549 cells exhibited enhanced proliferative activity in 1% bovine serum that contained medium, and dramatic changes in expression levels were observed in a large number of genes. (nih.gov)
The directed expression of SV40 T antigen has led to the development of several important transgenic models with spontaneous epithelial tumor formation. (molvis.org)
In summary, SNPs in SERPINE1 and ARNTL and an SNP associated with the expression of MUC3 were robustly associated with circulating levels of PAI-1. (ox.ac.uk)
The SS18-SSX oncoprotein, characteristic of synovial sarcoma, maintains EGR1 expression at low levels, whereas it is significantly increased after HDAC inhibitor treatment. (nature.com)
1996). Expression of Egr-1 correlates with the transformed phenotype and the type of viral latency in EBV genome positive lymphoid cell lines. (nature.com)
In contrast to monocytes, human macrophages did not show increased tissue factor expression upon stimulation with lipopolysaccharide and interferon-γ. (haematologica.org)
Furthermore, it was revealed that treatment with vitexin induced hypoxia inducible factor 1α subunit (HIF‑1α) and vascular endothelial growth factor (VEGF) protein expression, and suppressed phosphorylated‑p38 MAP kinase (p38) protein expression in sevoflurane‑induced newborn rat. (spandidos-publications.com)
Upregulation of HIF-1 expression may play a neuroprotective role in animal models of focal cerebral ischemia ( 6 ). (spandidos-publications.com)
Cytokine expression in tumors was determined by multiplex ELISA. (bmj.com)
LPS effectively inhibited cell viability and LC3B I expression and enhanced LC3B II, Beclin-1 and atg5 expressions in MLE-12 cells. (karger.com)
3-methyladenine promoted cell viability and ZO-1 expression, down-regulated Beclin-1 and atg5 expression, while Rapamycin (Rap) had an opposite effect. (karger.com)
Astragaloside IV suppressed cell viability and ZO-1 expression after the Rap treatment. (karger.com)
The expression of TF and PAI‑1 were determined using western blotting and reverse transcription‑quantitative PCR. (spandidos-publications.com)

Fibrinogen and PAI-1 are key components of the highly regulated coagulation process. (oxfordbiomed.com)
In addition, acquired disorders such as coagulation factor inhibitors affect adults more often than children. (medscape.com)

Normally, a potent, complex, immunologic cascade ensures a prompt protective response to microorganism invasion in humans. (medscape.com)
Mignatti, P. and Rifkin, D.B. (1993) Biology and biochemistry of proteinases in tumor invasion. (scirp.org)

The plasminogen activator (PA)-plasmin proteolytic system has recently received considerable attention because of its participation in a wide variety of biological activities and in pathological conditions involving tissue destruction. (ispub.com)

The protein also has a role as an acute-phase protein and is active in the control of immunologic and inflammatory processes, and as a tumor marker. (lookformedical.com)
Acute respiratory distress syndrome (ARDS), which is an acute pulmonary inflammatory syndrome, is characterized by the diffuse inflammation in the lung parenchyma and osmotic pulmonary oedema [ 1 ]. (karger.com)

For breast cancer, estrogen and progesterone receptors are mandatory for predicting response to hormone therapy, human epidermal growth factor receptor-2 measurement is mandatory for predicting response to trastuzumab, and urokinase plasminogen activator/plasminogen activator inhibitor 1 may be used for determining prognosis in lymph node-negative patients. (ox.ac.uk)
In this study, we report a central role of the transcription factor, early growth response-1 (EGR1), in the regulation of HDAC inhibitor-induced apoptotic cell death in synovial sarcoma. (nature.com)
Hypoxia inducible factor-1 (HIF-1) is an oxygen-sensitive transcriptional regulator that regulates more than 70 downstream target genes, including vascular endothelial growth factor, erythropoietin, glucose transporter and so on ( 5 ). (spandidos-publications.com)
Growth inhibitor from BSC-1 cells closely related to platelet type beta transforming growth factor. (academicinfluence.com)
A highly immunogenic tumor transfected with a murine transforming growth factor type beta 1 cDNA escapes immune surveillance. (academicinfluence.com)
A localized hypoxic environment occurs during tumor growth necessitating an angiogenic response or tumor necrosis results. (biomedcentral.com)

Twist, Slug, and increased Snail at the tumour stromal border were associated with vascular factors (p ≤ 0.045). (bvsalud.org)

To examine evidence for biosynthesis of PAI-1 and Vn by Dami cells, we immunoprecipitated PAI-1 and Vn from the conditioned media of cells biosynthetically radiolabeled with 35S-methionine in the presence or absence of PMA. (mcmaster.ca)
In contrast to Hep G2 cells, which synthesize both PAI- 1 and Vn, only 35S-PAI-1 was recovered from PMA-treated Dami cells. (mcmaster.ca)
We examined binding and internalization (endocytosis) of PAI-1 and Vn by Dami cells using biotinylated analogs (b-PAI-1 and b-Vn). (mcmaster.ca)
The binding of b-Vn to cells was inhibited by the presence of PAI-1, and there was no evidence of specific b-PAI-1 binding or uptake to resting or PMA-treated cells. (mcmaster.ca)
In every 25 situations analyzed PAI-1 immunoreactivity was localized in fibroblast-like cells predominantly. (tam-receptor.com)
PAI-1 was also observed in some myoepithelial cells encircling periodic foci of ductal carcinoma (9 of 25) some endothelial cells (8 of 25) some cancers cells (3 of 25) plus some mast cells (6 of 25). (tam-receptor.com)
To conclude we have supplied a sturdy immunohistochemical process of recognition of PAI-1 and proven that most the PAI-1-expressing cells in intrusive ductal breasts carcinomas are myofibroblasts. (tam-receptor.com)
Telomerase maintains telomere structure in normal human cells. (kanazawa-u.ac.jp)
Inhibitors of histone deacetylase (HDAC) restore the p53 pathway in neuroblastoma cells. (nature.com)
5 Functionally, proinflammatory polarization leads to potent effector cells that kill intracellular micro-organisms and tumor cells. (haematologica.org)
in addition, obesity increases the production of IL-1β, which may have cytotoxic effects on beta islet cells [7]. (heraldopenaccess.us)
The following public debate carries you from the evolutionary origins and the key functional purposes of adipose tissue, via adipose-derived stem cells and adipokines straight to the neuroendocrine, immunomodulatory and central nervous effects of signals that originate in the subcutis - perhaps, the most underestimated tissue of the human body. (femininebeauty.info)
Studies evaluating the pharmacological effects of defibrotide on endothelial cells (ECs) were conducted primarily in the human microvascular endothelial cell line. (medscape.com)
Researchers started taking a closer look at PAI-1 in conjunction with a virus infection in human cells and mice cells and they noted that subjects whom had less ability to produce PAI-1, were far more vulnerable to Influenza-A infections. (carbomer.com)
After this realization, the Scientists performed their experiment using samples of both human and mice cells and infected them with the subtype H1N1, a popular member of a large family of flu viruses. (carbomer.com)
Then, cells were either transferred to a hypoxic environment (1% O 2 ) or maintained at normoxic conditions for an additional 48 hours. (biomedcentral.com)
For VEGF, the target of current therapies, this correlation between hypoxia and higher cytokine levels was greater in primary breast and lung carcinoma cells than in ovarian carcinoma cells or tumor cell lines. (biomedcentral.com)

The SYT protein involved in the t(X;18) synovial sarcoma translocation is a transcriptional activator localised in nuclear bodies. (nature.com)

A member of the serpin superfamily found in plasma that inhibits the lysis of fibrin clots which are induced by plasminogen activator. (lookformedical.com)

RAF265 uPA catalyzes the transformation from the inactive zymogen plasminogen towards the energetic broad-spectrum protease plasmin which can degrade many extracellular protein eg fibrin and laminin. (tam-receptor.com)
5 6 uPA-directed activation of plasminogen takes place mainly over the cell surface area after concomitant binding of uPA to its particular receptor uPAR and of plasminogen to protein with C-terminal lysines. (tam-receptor.com)
1 The hypothesis has been supported by quantification of uPA protein in components of main tumors including breast carcinomas demonstrating that high levels of uPA are correlated with a poor prognosis. (tam-receptor.com)
To this end, tumor-released uPA-PAI-1 utilizes very low density lipoprotein receptor and ERK mitogen-activated protein kinases to initiate a pro-inflammatory program in peritumoral macrophages. (bmj.com)
On the onset of hyperglycemia, however, elevated mitochondrial aerobic respiration and activity of the electron transport chain, as well as advanced glycated end products, aggravates oxidative stress, which presents another activator of inflammatory cascades mediated by NF-κB, cAMP-regulated element-binding protein, and activator protein 1 [31] [ 22 ] . (encyclopedia.pub)
6 ) suggest that low-density lipoprotein (LDL) regulates PAI-1, uPA, and tPA in biphasic patterns in HMC, and the up regulation of PAI-1, uPA, and tPA after long-term LDL exposure seems to be mediated by a delayed protein kinase C (PKC) activation associated with an increased PA inhibitory activity. (ispub.com)
This protein is called PAI-1 or Plasminogen Activator Inhibitor 1. (carbomer.com)
This defensive mechanism seen in PAI-1 led the scientist's curiosity to see if the protein would do the same when a cell became infected with a virus. (carbomer.com)

The American Society of Clinical Oncology recommends using uPA and PAI-1 levels in breast tumors for deciding whether patients with newly diagnosed node-negative breast cancer can forgo adjuvant chemotherapy. (jcancer.org)
The tumor degree of plasminogen activator inhibitor-1 (PAI-1) can be an informative biochemical marker of an unhealthy prognosis in a number of cancer types. (tam-receptor.com)
14 In addition the value of PAI-1 like a predictor of poor prognosis in breast cancer is self-employed of tumor size and of estrogen receptor status 15 and the prognostic value of combined measurement of uPA and PAI-1 levels in tumor extracts is independent of the prognostic value of HER2 status. (tam-receptor.com)
Each of the three EMT-regulating transcription factors were associated with aggressive tumour features and shorter time to recurrence and cancer-specific death. (bvsalud.org)
METHODS: Published reports relevant to use of tumor markers for 5 cancer sites--testicular, prostate, colorectal, breast, and ovarian--were critically reviewed. (ox.ac.uk)
Unlike cancer arising in the human population, tumors in genetically engineered mouse models arise in mice with well defined genetic backgrounds where genetic variability can be minimized. (molvis.org)
We provide biomedical researchers with the best tools available for the analysis of Oxidative Stress and Chronic Inflammation - two of the most important risk factors that play key roles in the development of a wide range of human illness, including cancer, cardiovascular disease, diabetes and neurodegeneration. (oxfordbiomed.com)
[ 1 ] At this time, the ACS is in the process of updating the breast cancer screening guidelines for women at high risk, which were last updated in 2007. (medscape.com)

To understand if polarization of macrophages can lead to a procoagulant macrophage subset we polarized human monocyte derived macrophages to a proinflammatory and an alternative activation state. (haematologica.org)

Extracellular protease inhibitors that are secreted from FIBROBLASTS. (lookformedical.com)

uPA, PAI-1 and interleukin-6 were determined by enzyme linked immunosorbent assay (ELISA) in non oncological diseases (n=34) and in healthy individuals (n=20) and correlated with vitamin E treatment after operations. (ispub.com)

This upregulation was correlated with tumor progression. (molvis.org)
We also demonstrated upregulation of ETS-1 and ETS-2 target expressions in Tyrp-1-TAg mice when comparing with the same target expressions in control mice. (molvis.org)

The aim of the present study was to determine whether BAY11‑7082, an inhibitor of the NF‑κB pathway, inhibits the expressions of tissue factor (TF) and plasminogen activator inhibitor‑1 (PAI‑1) in AECⅡ in response to TNF‑α. (spandidos-publications.com)
In conjunction with inflammation, changes in tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) have been associated with increased risk of cardiovascular disease. (cdc.gov)

It elicits antithrombotic and fibrinolytic properties and may increase prostaglandin E2 and prostacyclin levels, alter platelet activity, and increase tissue plasminogen activator function while decreasing tissue plasminogen activator inhibitor activity. (medscape.com)

Elevated PAI-1 transcription has been reported to be caused by oxidative stress activation of the AP-1 response element. (oxfordbiomed.com)

At the moment of writing this article, 41 million children of age 5 or less are affected by obesity in the world [1]. (heraldopenaccess.us)

Type 1 plasminogen activator inhibitor (PAI-1) and its cofactor vitronectin (Vn) are stored within the alpha-granules of platelets. (mcmaster.ca)
The genesis of diabetic nephropathy (DN) in type 2 diabetes mellitus is clearly multifactorial, involving hypertension, hyperglycemia, hyperinsulinemia, and hyperlipidemia [ 1 - 6 ]. (hindawi.com)
Interestingly, comparisons between type 1 and type 2 diabetic individuals further confirm the fact that CAN processes in T2D start earlier than the onset of overt metabolic impairment [2] [ 1 ] . (encyclopedia.pub)
tissue-type plasminogen activator ), aktywujący plazminogen w obecności powstałego włóknika. (czytelniamedyczna.pl)

National Academy of Clinical Biochemistry laboratory medicine practice guidelines for use of tumor markers in testicular, prostate, colorectal, breast, and ovarian cancers. (ox.ac.uk)
The role of two members of the ETS (E26 avian leukemia oncogene) family of transcription factors, ETS-1 and ETS-2, has been investigated in many cancers but has not yet been studied in ocular tumors. (molvis.org)
Chemotherapy, radiation therapy, and surgical removal of the tumors are standard methods implemented to cure breast cancers. (degruyter.com)

Fibrinolytic system may participate directly in tumor progression by plasmin activity, or indirectly via metalloproteinases regulation as well. (czytelniamedyczna.pl)

The concentrations of TF and PAI‑1 in culture supernatant were also measured by ELISA. (spandidos-publications.com)

Urokinase plasminogen activator (uPA) and urokinase plasminogen activator receptor (uPAR) are the central molecules for uPA/uPAR/plasmin-dependent proteolysis, which is thought to play a significant role in the development of pregnancy, as well as its many complications during pregnancy. (ispub.com)

The amino acid sequence of mouse PAI-1 is 89%, 79% and 76% identical to that of rat, human/chimpanzee and dog. (rndsystems.com)

High plasma levels of PAI-1 have been associated with an increased risk of suffering cardiovascular diseases. (ptglab.com)
Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation. (ox.ac.uk)
Not surprisingly, they discovered that the patients with mutated SERPINE1 genes (which don't produce high levels of PAI-1), were heavily impacted by viral infections. (carbomer.com)
In LPS-induced ARDS cell model, astragaloside IV up-regulated cell viability, SOD activity and ZO-1 and LC3B I expressions but down-regulated cell apoptosis, TNF-α, IL-6, LC3B II, Beclin-1 and atg5 expressions and LDH and MDA levels. (karger.com)
Moreover, levels of NF‑κB p65 (p65), phosphorylated (p)‑p65 (p‑p65), inhibitor of NF‑κB α (IκBα) and p‑IκBα were also evaluated. (spandidos-publications.com)
However, AECII pre‑treated with BAY11‑7082 expressed lower levels of TF and PAI‑1 following TNF‑α treatment. (spandidos-publications.com)

These results suggest that LDL, after prolonged incubations with HMC, causes a PA/inhibitor imbalance favoring accumulation of matrix. (ispub.com)

These data suggest that accumulation of PAI-1 in Dami cell storage granules is due to endogenous synthesis and that the accumulation of Vn is due to endocytosis of serum-derived Vn. (mcmaster.ca)

Tumour slides from 67 patients (radical prostatectomies) were stained for Nestin-Ki67. (bvsalud.org)
As a personalized immunotherapeutic strategy, blockade of uPA-PAI-1 heteromerization might be particularly beneficial for patients with highly aggressive uPA-PAI-1 high tumors. (bmj.com)
The purpose of this study was to determine whether there is a stimulation of production of uPA, PAI-1 and interleukin-6 before and after operation in plasma patients with gynecological diseases, and whether vitamin E could inhibit this process. (ispub.com)
uPA, PAI-1, and interleukin-6 were significantly higher after abdominal gyneocological operation than before operation in the group of patients who were not treated with vitamin E after operation (P≤ 0.0001). (ispub.com)
Veno-occlusive disease in pediatric patients affected by Wilms tumor. (medscape.com)
A Phase Ib Study Assessing the Safety, Tolerability, and Efficacy of the First-in-Class Wee1 Inhibitor Adavosertib (AZD1775) as Monotherapy in Patients with Advanced Solid Tumors. (cdc.gov)

We have studied the transgenic mouse strain, Tyrp-1-TAg, to try to gain insight into possible molecular mechanisms common to pigmented ocular neoplasms occurring spontaneously in the eyes of these mice and human choroidal melanoma. (molvis.org)

PAI-2 assists PAI-1 in regulating fibrinolysis and may help prevent overexpression of PAI-1, which increases risk of thrombosis. (wikipedia.org)

Together, the results of the current study suggest that the protective effect of vitexin reduces sevoflurane‑induced neuronal apoptosis through HIF‑1α‑, VEGF‑ and p38‑associated signaling pathways in newborn rats. (spandidos-publications.com)

Anatomy23

Organisms11

Diseases29

Chemicals and Drugs112

Analytical, Diagnostic and Therapeutic Techniques and Equipment36

Phenomena and Processes46

Disciplines and Occupations1

Information Science3

Health Care5

Necrosis factor5

Metastasis12

Urokinase-type plasminogen2

Microenvironment4

Angiogenesis6

Inactivates tissue2

Proteins4

MRNA6

Thrombin4

Neutrophil infiltration1

Breast tumor3

Vitro2

Epithelial Cells1

Several tumor types1

Prevented tumor progression1

Serine protease1

Polymorphism1

Principal inhibitor2

Inhibition9

Gene8

Expression15

Coagulation2

Invasion2

Proteolytic1

Acute2

Growth6

Stromal1

Cells17

Transcriptional1

Superfamily1

Protein8

Cancer8

Monocyte1

Extracellular1

Enzyme linke1

Upregulation2

Tissue factor2

Platelet1

Oxidative stress1

Obesity1

Type4

Cancers3

Fibrinolytic1

ELISA1

Receptor1

Amino acid seq1

Levels6

Imbalance1

Endogenous1

Patients6

Mice1

Thrombosis1

VEGF1