Tumor genome proteins expressed sequence tags. Medical search. Frequent questions

As whole genome sequences became available, again with the pioneering work of Frederick Sanger, the term bioinformatics was re-discovered to refer to the creation of databases such as GenBank in 1982. (ind.in)
Whole-genome studies have provided a useful insight into how gene patterns may influence the development and/or progression of certain pathological pathways, including fibrosis [ 2 ]. (biomedcentral.com)
1 Covering over 17,000 human and over 20,000 mouse genes with two optimized gRNAs for each of them, our Sanger Whole Genome Arrayed Libraries are powerful tools that can help you make the next exciting discovery. (sigmaaldrich.com)
Our exclusive Sanger CRISPR library provides extensive, high-quality gene knockout, so you can fast-track your research with the first whole genome arrayed library. (sigmaaldrich.com)
The Sanger library is the only tool that allows both whole genome CRISPR KO interrogation and sophisticated phenotypic readout in a convenient arrayed format. (sigmaaldrich.com)
First, Tim Graubert and colleagues describe the whole-genome sequencing of an MDS-derived secondary AML tumor and a matched normal (skin) sample. (massgenomics.org)

Its cDNA sequence contained an open reading frame encoding a 431-amino acid peptide that showed a significant homology with members of the P2X family. (aacrjournals.org)
Complementary DNA (cDNA) is a double-stranded DNA molecule, in which one of its strands constitutes a sequence totally complementary to the messenger RNA from which it has been synthesized. (andrologica.org)
Deep cDNA sequencing demonstrated that both wild-type and mutant alleles were expressed . (massgenomics.org)

Description: Anti-HA magnetic beads kit is based on hydroxyl magnetic beads covalently coupling with high quality mouse IgG2b monoclonal antibody, used for co-immunoprecipitation and protein purification. (nfkbcell.com)
Description: Anti-Myc magnetic beads kit is based on hydroxyl magnetic beads covalently coupling with mouse IgG1 monoclonal antibody.it is recommended to use for co-immunoprecipitation and protein purification. (nfkbcell.com)
Compared to similar immune magnetic beads, our Protein A/G beads display much more antibody binding sites therefore using less magnetic beads per reaction and ultimately achiving greater cost-efficiency. (nfkbcell.com)
Another early contributor to bioinformatics was Elvin A. Kabat , who pioneered biological sequence analysis in 1970 with his comprehensive volumes of antibody sequences released with Tai Te Wu between 1980 and 1991. (ind.in)
The oncolytic adenovirus ICOVIR-15K was engineered to express an EGFR-targeting BiTE (cBiTE) antibody under the control of the major late promoter, leading to generation of ICOVIR-15K-cBiTE, which retained its oncolytic properties in vitro . (aacrjournals.org)
Renowned as the #1 antibody event in the industry, this year's agenda boasts 15 dedicated topic streams, 3 unmissable training course add-on options and will bring together more than 700 of the antibody and protein community. (cshlpress.com)
This goal is accomplished by tagging an antibody with a uniquely identifiable agent that is a surrogate for the level of expression of a given cellular constituent. (nature.com)
Fluorescence and isotope tagging are the principal means for measuring antibody binding to cells in flow cytometry. (nature.com)

Although we detected no genetic alteration in the coding sequences, one of four rhabdomyosarcoma cell lines examined had completely lost expression of this gene. (aacrjournals.org)
Sequence homology is an indication of the genetic relatedness of different organisms and gene function. (lookformedical.com)
To prevent companies and governments from stealing genes, invading genetic privacy and undermining human rights and dignity, we urgently need a Genetic Bill of Rights and a Global Ethics Council, Mae-Wan Ho warns of the fall-outs from the human genome project. (i-sis.org.uk)
Mice are also easy to breed with a short generation time and a short life span allowing direct study of disease development and can accurately eludicidate how genetic sequences may vary in different strains and result in susceptibility to fibrotic pathologies. (biomedcentral.com)
A codon is a DNA or RNA sequence of three nucleotides (a trinucleotide) that forms a unit of genetic information encoding a particular amino acid. (genome.gov)
They are used for clinical purposes such as the possibility of transplants, the genetic instability of tumors, etc. (andrologica.org)
used genetic techniques to silence PVRL4 in cells from breast tumors, they found that it reduced the formation of clusters by the cancer cells and also reduced their ability to grow in the absence of attachment. (elifesciences.org)
This paper reviews the current knowledge regarding gynecologic tumor derived-exosomal genetic material and proteins, their role in cancer progression, and their potential for advancing the clinical care of patients with gynecologic cancers through novel diagnostics and therapeutics. (allergy-link.com)

This may contribute to the generation of active RON variants by alternative splicing, which is frequently observed in primary tumors. (spandidos-publications.com)
In primary tumors, such as colon and breast cancers, overexpression of RON exists in a large number of cases and is often accompanied by the generation of different splicing variants ( 12 - 14 ). (spandidos-publications.com)

Raccoon polyomavirus may contribute to the development of malignant brain tumors of raccoons. (cdc.gov)
Furthermore, transgenic mice harboring the viral-encoded large T-antigen (LT-Ag) alone develop tumors of neuroectodermal origin, including malignant peripheral nerve sheath tumors (MPNSTs) and glioblastomas. (cdc.gov)

Right here we report the interim integrative evaluation of DNA copy quantity, gene expression and DNA methylation aberrations in 206 glioblastomas-the commonest kind of grownup mind cancer-and nucleotide sequence aberrations in 91 of the 206 glioblastomas. (nfkbcell.com)
It is also called nucleotide sequence. (lookformedical.com)
An expressed sequence marker or EST (acronym in English: Expressed Sequence Tag) is a small subsequence of a transcribed nucleotide sequence (encoding a protein or not). (andrologica.org)

These findings uncover a previously unknown tumor suppressor role for ZNF148, and a transcriptional regulatory circuitry encompassing MYC, ZNF148, and ID1/3 in driving cancer stem cell traits in aggressive breast cancer. (nature.com)
Germline loss of function mutations followed by somatic loss of non-mutant alleles in the tumours 2- 4 suggests a tumour suppressor role for mitochondrial complex II in the paraganglia. (bmj.com)

Some pathological processes, for example, tumorigenesis and solid tumour growth, in which the former is derived from a single-cell and the latter has a mixed-cell problem, present new challenges to the limit of these functional genomic techniques. (ejbiotechnology.info)
To fully understand the functions of cells in tumorigenesis or in heterogeneous solid tumour masses, it is essential for scientists and physicians to develop a strategy to identify genomic expression profiles for a single-cell or for small numbers of cells. (ejbiotechnology.info)
In addition, the paper will review different techniques of single-cell genomic expression at the level of DNA, mRNA, protein and post-translational modifications. (ejbiotechnology.info)
An allele is one of two or more versions of DNA sequence (a single base or a segment of bases) at a given genomic location. (genome.gov)
Therefore comparative genomic analysis of T . equi was undertaken to: 1) identify genes contributing to immune evasion and persistence in equid hosts, 2) identify genes involved in PBMC infection biology and 3) define the phylogenetic position of T . equi relative to sequenced apicomplexan parasites. (biomedcentral.com)
Comparative genomic analysis of T . equi revealed the phylogenetic positioning relative to seven apicomplexan parasites using deduced amino acid sequences from 150 genes placed it as a sister taxon to Theileria spp . (biomedcentral.com)

Southern blot hybridization and rolling circle amplification showed the episomal viral genome in the tumors. (cdc.gov)

Techniques such as microarrays, expressed tag sequencing (EST), serial analysis of gene expression (SAGE), subtractive cloning and differential display (DD), and two-dimensional electrophoresis gel have been extensively used to screen and analyze parallel gene expression. (ejbiotechnology.info)
Microarrays were prepared in tumor biology. (lu.se)
Young's team was at the time using DNA microarrays-glass slides peppered with short DNA sequences-to fish out the full spectrum of genes expressed by cells in response to various stimuli. (ludwigcancerresearch.org)

Human AMFR genome location and AMFR gene details page in the UCSC Genome Browser. (wikipedia.org)
Bortoluzzi S, Alessi FD, Romualdi C, Danieli GA: Differential expression of genes coding for ribosomal proteins in different human tissues. (karger.com)
Through cloning of functional p53-binding sites (p53-tagged sites) from the human genome, we isolated a novel gene inducible by wild-type p53. (aacrjournals.org)
However, natural disease studies of human infection and experimental disease studies suggest that a potential outcome of some polyomavirus (PyV) infections is tumor formation ( 4 - 6 ). (cdc.gov)
The Most cancers Genome Atlas (TCGA) pilot undertaking goals to evaluate the worth of large-scale multi-dimensional evaluation of those molecular traits in human most cancers and to present the info quickly to the analysis neighborhood. (nfkbcell.com)
Copies of the LINE 1 (L1) family form about 15% of the human genome. (lookformedical.com)
DNA transposable elements include bacterial IS (insertion sequence) elements, Tn elements, the maize controlling elements Ac and Ds, Drosophila P, gypsy, and pogo elements, the human Tigger elements and the Tc and mariner elements which are found throughout the animal kingdom. (lookformedical.com)
The length of the human genome is about 3 billion base pairs. (lookformedical.com)
These are some of the fall-outs from the Human Genome Project (see Human Genome: The Biggest Sellout in Human History, this issue). (i-sis.org.uk)
Assembly of the human genome is one of the greatest achievements of bioinformatics. (ind.in)
Mice provide a suitable model for the study of human genetics because more than 95% of the genome is identical. (biomedcentral.com)
The glossary features nearly 250 terms explained in an easy-to-understand way by leading scientists and professionals at the National Human Genome Research Institute. (genome.gov)
If the human genome is a recipe book, its chapters are 23 distinct chromosomes, each of which is stuffed, in rough duplicate, into the nucleus of almost all the cells of the human body. (ludwigcancerresearch.org)
To help you unravel your genes and pathways of interest, we collaborated with The Wellcome Sanger Institute to make the first arrayed lentiviral CRISPR knockout libraries for human and mouse genomes. (sigmaaldrich.com)
There are works about, how single nucleotide polymorphisms, or SNPs (pronounced «snips»), in the human genome correlate with disease, with drug response, and other phenotypes. (andrologica.org)
SNP, or single nucleotide polymorphisms, are responsible for a large part of the diversity of the human genome. (andrologica.org)
Governments in the industrialized countries have handed over the human genome to private ownership together with the most triumphant hyperboles to boot, notwithstanding that it was mapped and sequenced at great public expense. (biosafety-info.net)
The human genome programme has dominated the scientific scene for the past ten years, raising hopes and fears in equal measure. (biosafety-info.net)
Otherwise, human genome research will remain a scientific and financial black hole that swallows up all public and private resources without any return either to investors or to improving the health of nations. (biosafety-info.net)
That was how Clinton greeted the announcement of the human genome map on June 26 (1). (biosafety-info.net)
The Human Genome Project, (HGP) an international public consortium of research laboratories led by the United States, and Celera, a private American company, made the announcement jointly, ending months of competition to complete the first sequence of the human genome. (biosafety-info.net)
The human genome has been sequenced separately and independently with major public finance, from the United States and the European Community. (biosafety-info.net)
But that has not prevented the human genome from being owned and exploited by private companies. (biosafety-info.net)
Earlier in March, Clinton and Blair released an ambiguous statement calling for open access to the human genome data. (biosafety-info.net)
Celera kept its own human genome data secret while benefiting from free access to the public database throughout the period that the company was busy sequencing, thereby significantly reducing the time and effort needed to complete the task. (biosafety-info.net)
Human Genome Sciences has won more than 100 gene patents and filed for roughly another 7000. (biosafety-info.net)
However, large-scale nucleotide sequencing directed at the human genome (3 billion nucleotides! (nationalacademies.org)
It is this side of molecular biology that is data intensive and is embodied in the Human Genome Project, a burgeoning scientific endeavor producing vast amounts of new information that researchers must select from to advance their investigations. (nationalacademies.org)
AN - check the tag INFANT HN - 2008 FX - Child Nutrition FX - Infant Nutrition Physiology FX - Milk FX - Milk, Human DH - Adolescent Nutrition DI - 052508 MN - SP6.021.067 MS - Nutrition of persons 10 through 19 years of age. (bvsalud.org)

Tumor initiation and progression often involve the dysregulation of developmentally important genes in cancer cells, endowing them with stem cell-like features such as enhanced self-renewal, invasiveness, and an aberrant differentiation state [ 1 ]. (nature.com)
During all stages of tumor progression, cancer cells are subjected to inappropriate extracellular matrix environments and must undergo adaptive changes in order to evade growth constraints associated with the loss of matrix attachment. (elifesciences.org)

The genes encoding these proteins are highly conserved within the Trichinellids, are constituents of mL1 ESP and localized in the parasite stichosome. (westminster.ac.uk)

Rapid and comprehensive analysis of putative proteinous allergens ( allergenome ) by applying such a proteomic strategy … With allergenomics, we can not only detect and assign the putative allergens (proteins specifically interacting with IgE antibodies in a patient's blood) in a short time, but also analyze the quantitative and qualitative change of the antigens, depending on the surroundings and environmental conditions of an allergenic causative. (genomicglossaries.com)
In this study, we tested the hypothesis that tumor-infiltrating T cells could be more effectively activated and redirected by oncolytic adenoviruses that were armed with bispecific T-cell-engager (BiTE) antibodies. (aacrjournals.org)
It involved chemically gluing the proteins to their target DNA inside the cell and then using antibodies to pull the whole scrum down for subsequent analysis. (ludwigcancerresearch.org)
Furthermore, growth of orthotopically implanted tumors in vivo is inhibited by blocking PVRL4-driven cell-to-cell attachment with monoclonal antibodies, demonstrating a novel strategy for targeted therapy of cancer. (elifesciences.org)
Equivalent amounts of protein were separated on SDS-PAGE, transferred onto PVDF membranes and then incubated with main antibodies (Table 1). (healthanddietblog.info)

Autocrine motility factor is a tumor motility-stimulating protein secreted by tumor cells. (wikipedia.org)
The receptor, which shows some sequence similarity to tumor protein p53, is localized to the leading and trailing edges of carcinoma cells. (wikipedia.org)
Recepteur d'origine nantais (RON) is a receptor tyrosine kinase (RTK) normally expressed at low levels in epithelial cells. (spandidos-publications.com)
RON was found to be primarily expressed in cells of epithelial origin such as colon, breast and skin ( 9 ). (spandidos-publications.com)
The multifunctional nuclear protein large T-antigen was detectable by immunohistochemical analyses in a subset of neoplastic cells. (cdc.gov)
Your gene sequences and cells may be patented and sold on the open market without your ever knowing about it. (i-sis.org.uk)
These concerted processes change the spectrum of genes expressed by GBM cells. (sciencedaily.com)
The interlinked phenomena, the team reports, are reflected in a global database of the genes expressed in GBM cells and seen in tumors expressing EGFRvIII obtained from GBM patients. (sciencedaily.com)
This protein controls the expression and activity of yet another transcription factor, cMyc, which plays a central role in driving the aberrant metabolism and growth of GBM cells. (sciencedaily.com)
The researchers show that treatment with JQ1 induces the death of EGFRvIII fueled GBM cells, and shrinks GBM tumors in a mouse model. (sciencedaily.com)
Despite the existence of a highly immunosuppressive tumor environment, adenovirus-infected cells can nonetheless be efficiently cleared by infiltrating cytotoxic T lymphocytes (CTL) without compromising tumor burden. (aacrjournals.org)
Notably, intratumoral injection of this cBiTE-expressing adenovirus increased the persistence and accumulation of tumor-infiltrating T cells in vivo , compared with the parental virus lacking such effects. (aacrjournals.org)
It explains how all these different types of cells in the body emerge from the information encoded by the genome. (ludwigcancerresearch.org)
Despite this, clinical responses are typically transient as tumour cells develop resistance. (babraham.ac.uk)
It is estimated that up to 90% of cancers in humans originate in epithelial tissue, and the cells within such tumors are known to survive and divide even when they are no longer attached to the extracellular matrix. (elifesciences.org)
Understanding how cancerous cells gain this ability may lead to new approaches to stopping tumor cells from dividing and colonizing tissues around the body. (elifesciences.org)
They found that the gene that codes for a protein called poliovirus receptor-like 4 (PVRL4) allows attachment-free cell growth and also makes cells cluster together once detached from the matrix. (elifesciences.org)
Normally, the PVRL4 gene is not active in breast epithelial cells, but its activity is detected in many breast, lung, and ovarian tumors. (elifesciences.org)
This behavior is particularly evident in the cells that divide aggressively to form tumors that subsequently migrate and colonize other tissues around the body. (elifesciences.org)
also showed that interactions between the PVRL4 in one cell and a related protein called PVRL1 in a neighboring cell were responsible for holding the cells together in clusters. (elifesciences.org)
Mutant allele frequencies were at 40-50% , suggesting that the mutation was present in most or all tumor cells. (massgenomics.org)
We present a method enabling simultaneous, ultra-high throughput single-cell barcoding of millions of cells for targeted analysis of proteins and RNAs. (nature.com)
With minimal instrumentation (four 96-well plates and a multichannel pipette), cell-specific codes are added to each tagged molecule within cells through sequential rounds of classical split-pool synthesis. (nature.com)
check the tag ADOLESCENCE HN - 2008 BX - Nutrition in Adolescence FX - Adolescent Nutrition Physiology MH - Peritoneal Stomata UI - D054048 MN - A01.047.025.600.700 MN - A10.810 MS - Natural openings in the subdiaphragmatic lymphatic plexus in the PERITONEUM, delimited by adjacent mesothelial cells. (bvsalud.org)

P2XM was localized to chromosomal band 22q11, where frequent loss of heterozygosity has been observed in rhabdoid tumors. (aacrjournals.org)

An amino acid is the fundamental molecule that serves as the building block for proteins. (genome.gov)
An anticodon is a trinucleotide sequence located at one end of a transfer RNA (tRNA) molecule, which is complementary to a corresponding codon in a messenger RNA (mRNA) sequence. (genome.gov)
Each time an amino acid is added to a growing polypeptide during protein synthesis, a tRNA anticodon pairs with its complementary codon on the mRNA molecule, ensuring that the appropriate amino acid is inserted into the polypeptide. (genome.gov)

We have identified a candidate etiologic agent, dubbed raccoon polyomavirus, that was present in the tumor tissue of all affected animals but not in tissues from 20 unaffected animals. (cdc.gov)

Now, his scientific forays into the cell's nucleus are illuminating how the genome controls its own expression-and how that control runs awry in diseases such as cancer. (ludwigcancerresearch.org)
If outer space once disappointed, Ren has had much better luck with the inner variety: His scientific forays into the cell's nucleus are illuminating how the genome controls its own expression-and how that control runs awry in diseases such as cancer. (ludwigcancerresearch.org)

Recent advances in functional genomics allow us to estimate the expression of several thousands of genes in the mammalian genome. (ejbiotechnology.info)

One of these locations is found in about one out of every 1,100 letters of the code, meaning that there are roughly 4 to 5 million SNPs in a person's genome. (andrologica.org)
Most SNPs do not have much meaning, because they are in a part of the genome that does not have a critical function. (andrologica.org)

7- 9 All reported mutations are single nucleotide alterations leading to splice site, missense, nonsense, or frameshift mutations, or intra-exonic deletions and insertions of up to four nucleotides, which have been detected through exonic PCR amplifications and sequencing. (bmj.com)

Sequences of DNA in the genes that are located between the EXONS. (lookformedical.com)
The authors undertook systematic sequencing of U2AF1 exons in 150 MDS cases, and found that 8.7% had mutations at Ser34. (massgenomics.org)

DNA isolation, genotyping of simple tandem repeat polymorphisms, PCR amplification and sequencing were performed using standard techniques 2 and all simple tandem repeat polymorphisms were amplified in the presence of 10% glycerol and 5% DMSO after labelling one oligonucleotide primer with 32 P and analysed on a 6% polyacrylamide gel. (bmj.com)

Genes contributing to the similarity include ribosomal protein (RP) genes as well as genes involved in transcription, translation and cell division. (karger.com)
This protein also revealed a similarity to RP-2 , a gene activated in thymocytes undergoing programmed cell death. (aacrjournals.org)

Total RNA from tumors the expression of thousands of genes (3) to address complex questions was isolated using two successive rounds of Trizol. (lu.se)

DCAF14 functions at stalled replication forks to promote genome stability, but the mechanism is unknown. (bvsalud.org)
One branch addresses a range of integrated biological systems, concentrating on the function of protein molecules in the processes of DNA replication and mutagenesis, transcription, and translation. (nationalacademies.org)

An initiative of the U.S. National Institutes of Health, the project had explored how chromatin-DNA and its protein scaffolding-is chemically tagged to control gene expression. (ludwigcancerresearch.org)

It is recommended to use for co-immunoprecipitation and protein purification. (nfkbcell.com)

Indeed, a number of genes identified as potential manipulators of the host cell phenotype are absent from the T . equi genome. (biomedcentral.com)

In contrast, the gene sequences and gene maps produced by the public consortium have been deposited regularly within 24 hours of completion in GenBank, a public database set up in the early 1980s when DNA sequencing began, access to which is totally free. (biosafety-info.net)

EGFRIII changes the cell's internal signaling network, its uptake and use of nutrients, key elements of its gene-reading machinery known as transcription factors and its epigenetic landscape--the distribution of chemical tags that determines which parts of its genome are available for reading. (sciencedaily.com)
Using technology developed in Ren's laboratory, the researchers began by profiling EGFRvIII's specific epigenetic activation of DNA sequences known as "enhancers. (sciencedaily.com)

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. (lookformedical.com)
Both technologies have been primarily focused on measurement of protein epitopes, but have been used to measure nucleic acids such as targeted mRNA 11 , 12 . (nature.com)

Solid tumors frequently have copy number gains of the PVRL4 locus and some have focal amplifications. (elifesciences.org)

ER protein determinations were performed using two-thirds of all breast cancers are ER at the time of diagnosis, the standard methods in the routine clinical laboratory (9). (lu.se)

In situ hybridization (ISH) uses complementary DNA or RNA probes to localize a specific DNA or RNA sequence in in tissue sections. (technologypublisher.com)
As with other detection techniques, ISH requires that the sequence of the target be known so that complementary probe sequence can be synthesized and tagged, with visualization aids, for use as hybridization probes. (technologypublisher.com)
Using in-situ hybridization (ISH) to diagnose canine herpesvirus increases the accuracy of proper diagnoses compared to current methods by detecting in the genome. (technologypublisher.com)

Polymorphisms can have different functional significance, depending on whether they affect a coding region of the genome, a regulatory region or a non-coding region. (andrologica.org)
However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. (origene.com)

Protein concentration was quantified using a Bradford protein assay Kit (Beyotime Biotechnology, Shanghai, China). (healthanddietblog.info)

RON is activated in response to macrophage-stimulating protein (MSP), and then induces an invasive program ( 8 ) consisting of cell proliferation, migration, and invasion, all of which are important at multiple points during tumorigenesis. (spandidos-publications.com)
JCV, for example, induces brain tumors when intracerebrally inoculated in experimental animals ( 7 - 11 ). (cdc.gov)

In a cell, antisense DNA serves as the template for producing messenger RNA (mRNA), which directs the synthesis of a protein. (genome.gov)

Autocrine motility factor receptor, isoform 2 is a protein that in humans is encoded by the AMFR gene. (wikipedia.org)
The protein encoded by this gene is a glycosylated transmembrane protein and a receptor for autocrine motility factor. (wikipedia.org)
A team of Ludwig Cancer Research scientists has mapped out how a mutant version of the epidermal growth factor receptor (EGFR) known as EGFRvIII specifically drives critical processes that alter the reading of the genome to fuel the growth of the brain cancer glioblastoma multiforme and -- most important -- how each process is linked to the other. (sciencedaily.com)

A collection of different allotypes or allelic protein variants, a new type of protein library. (genomicglossaries.com)
They detected and validated 507 somatic single-nucleotide variants in the tumor, nearly all of which (505) were detected in the MDS sample . (massgenomics.org)

About 60% of GBM tumors are fueled by the mutation or rampant over-expression of EGFR, most often by the EGFRvIII mutant. (sciencedaily.com)
Most of the enhancers activated by EGFRvIII bore signature DNA sequences that are bound by dozens of transcription factors--regulators of gene expression--expressed at high levels in GBM. (sciencedaily.com)
Ren focused on how specialized proteins called transcription factors control gene expression by recognizing unique DNA sequences. (ludwigcancerresearch.org)
Scope includes mutations and abnormal protein expression. (cancerindex.org)
This clone was engineered to express the complete ORF with an expression tag. (origene.com)
The expression of 37 EV surface proteins was evaluated by flow cytometry using the MACSPlex Exosome kit . (allergy-link.com)

The extracellular sequences of RON contain several domains including an N-terminal semaphorin (sema) domain, followed by the plexin, semaphorin, integrin (PSI) domain, and four immunoglobulin, plexin, transcription factor (IPT) domains. (spandidos-publications.com)

This week in Nature Genetics , two studies report recurrent mutations in splicing-related genes in blood tumors. (massgenomics.org)

As was the norm at the time, he probed such interactions one at a time, outside the cell, binding the protein factors to their target DNA sequences in a test tube. (ludwigcancerresearch.org)

With 35,000 genes and hundreds of thousands of protein states to identify, correlate, and understand, it no longer suffices to rely on studies of one gene, gene product, or process at a time. (genomicglossaries.com)

The region of DNA which borders the 3' end of a transcription unit and where a variety of regulatory sequences are located. (lookformedical.com)
Nucleotide sequences, usually upstream, which are recognized by specific regulatory transcription factors, thereby causing gene response to various regulatory agents. (lookformedical.com)
Notably, silencing of the two transcription factors stopped tumor growth, both in cell cultures and in an animal model that mimics GBM. (sciencedaily.com)

RON is a 180-kDa heterodimeric protein composed of a 40-kDa α-chain and a 150-kDa transmembrane β-chain with intrinsic tyrosine kinase activity. (spandidos-publications.com)
Maturation occurs in the cell membrane resulting in a 180-kDa heterodimeric protein composed of a 40-kDa α-chain and a 150-kDa transmembrane β-chain with intrinsic tyrosine kinase activity ( 5 , 6 ). (spandidos-publications.com)
However, recent studies have suggested that BRAFi/MEKi and ERK1/2i resistance can arise through activation of a parallel signalling pathway leading to activation of ERK5, an unusual protein kinase that contains both a kinase domain and a transcriptional transactivation domain. (babraham.ac.uk)
In addition, eHSP90 induced ER stress in fibroblasts the phosphoinositide-4,5-bisphosphate 3-kinase (PI3K)-protein kinase B (AKT) signaling pathway, which could become blocked from the PI3K/AKT inhibitor LY294002, and blockade of eHSP90 by 1G6-D7 markedly inhibited ER stress in the model, indicating preventive and restorative applications. (healthanddietblog.info)

Thus, although PyV-induced oncogenesis in laboratory animals has been a prolific model for the study of the cell cycle and cell transformation, natural infections rarely result in tumor formation, so the steps in cell transformation after natural infection are being revealed more slowly. (cdc.gov)
Single-cell sequencing has made considerable progress relying on the notion that the sequence is the tag. (nature.com)

The system is based on the highly sensitive and quantitative Nanoluciferase that is conditionally expressed upon reporter-transcript editing. (cancerindex.org)

Anatomy9

Organisms14

Diseases45

Chemicals and Drugs38

Analytical, Diagnostic and Therapeutic Techniques and Equipment49

Phenomena and Processes105

Disciplines and Occupations5

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CDNA3

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Microarrays3

Human29

Progression2

Highly conserved1

Antibodies5

Cells24

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Molecule3

Tissues1

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Genomics1

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Exons2

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Similarity2

Thousands of genes1

Replication2

Chromatin1

Purification1

Phenotype1

Gene sequences1

Epigenetic2

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Locus1

Cancers1

Hybridization3

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Assay1

Induces2

MRNA1

Receptor3

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Expression6

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Probed such interac1

Correlate1

Transcription3

Kinase4

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Transcript1