Tumor endothelial cells lymphoma large cell anaplastic. Medical search. Frequent questions

2004) Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. (scielo.br)
Epidermal growth factor receptor (EGFR) is present in about 15% of non-small cell lung cancers in the U.S. EGFR-positive NSCLC can be treated with the tyrosine kinase inhibitors erlotinib (Tarceva), gefitinib (Iressa) or afatinib (Gilotrif). (pulmccm.org)
Non-small cell lung cancer (NSCLC) treatment in advanced stage like IIIB, IIIC, and IV is based on several driver mutations analysis including mutations/alterations of the epidermal growth factor receptor, anaplastic lymphoma kinase, ROS1, and PDL-1 expression. (asjo.in)
Notably, inhibition of GPR171 synergistically enhanced the tumoricidal activity of an epidermal growth factor receptor (EGFR) inhibitor in lung cancer cells. (oncotarget.com)
EGFR (epidermal growth factor receptor), ALK (anaplastic lymphoma receptor tyrosine kinase), RET (ret proto-oncogene receptor tyrosine kinase), and BRAF (B-Raf proto-oncogene, serine/threonine kinase) are well-identified oncogenic driver mutations in lung cancer, and are targets for therapeutic application. (oncotarget.com)

It is further divided into two subtypes, ALK positive (ALK+) and ALK negative (ALK-), based on whether they express anaplastic lymphoma kinase or not. (wikipedia.org)
In addition to binding to the insulin receptor, IRS1 also binds to and transmits signals from the receptors of prolactin, growth hormone (GH), leptin, vascular endothelial growth factor (VEGF), tropomyosin receptor kinase B (TrkB), anaplastic lymphoma kinase (ALK), insulin like growth factor (IGF1), and integrins ( Vuori and Ruoslathi , 1994 Vuori K and Ruoslahti E (1994) Association of insulin receptor substrate-1 with integrins. (scielo.br)
Anaplastic lymphoma kinase (ALK) is only present in about 4% of U.S. non-small cell lung cancers, often in younger, non-smoking patients. (pulmccm.org)
MRK ), known as MSD outside of the United States and Canada, and Eisai today provided updates on two Phase 3 trials, LEAP-006 and LEAP-008, evaluating KEYTRUDA, Merck's anti-PD-1 therapy, plus LENVIMA, the orally available multiple receptor tyrosine kinase inhibitor discovered by Eisai, in patients with certain types of metastatic non-small cell lung cancer. (streetinsider.com)
Protein kinase C regulates human pluripotent stem cell self-renewal. (rndsystems.com)
Which medications in the drug class Antineoplastic Agents, mTOR Kinase Inhibitors are used in the treatment of Non-Hodgkin Lymphoma (NHL)? (medscape.com)
This complex inhibits mammalian target of rapamycin (mTOR) kinase, a key protein in cells that regulate the gene translation responsible for cell-cycle regulation. (medscape.com)
Then, the C/EBP 3â UTR was found to directly inhibit the phosphorylation activity of protein kinase CPKC in SMMC-7721, a hepatocarcinoma cell line. (omicsonline.org)

Medulloblastoma is the most common malignant central nervous system (CNS) tumor of childhood, with an annual incidence of about 0.5-0.8/100,000 in children younger than 19 years. (medscape.com)
Blinatumomab is a bispecific T-cell engager (BiTE) targeting CD19 on malignant B cells and CD3 on normal host T cells. (hindawi.com)
1 , 2 Malignant brain tumors are characterized by neovascularity and increased angiogenic activity, with a higher proportion of immature and highly permeable vessels. (ajnr.org)
The medulloblastoma has been defined by the World Health Organization (WHO) as a "malignant, invasive embryonal tumor of the cerebellum with preferential manifestation in children, predominantly neuronal differentiation, and inherent tendency to metastasize via CSF [cerebrospinal fluid] pathways. (medscape.com)
Medulloblastoma is the most common malignant CNS tumor of childhood with an annual incidence of about 0.5-0.8/100,000 in children younger than 19 years. (medscape.com)
The differential diagnosis will include anaplastic ependymoma, atypical teratoid rhabdoid tumor (AT/RT), or other forms of highly proliferative malignant neuroectodermal tumors. (medscape.com)
Stage IV tumors have spread to the space between the layers lining the lungs (known as malignant pleural effusion) or to another region of the body. (medpagetoday.com)
Ab-3 shows no reaction with a variety of normal tissues .CEA is not found in benign glands, stroma, or malignant prostatic cells. (samatashkhis.com)
High-grade glioma (HGG) are the most frequent malignant primary brain tumor, which account for 80% of all gliomas in the United States, and are encountered with an annual incidence of 5.26 per 100,000 population, or 17,000 new cases diagnosed per year. (surgicalneurologyint.com)
The importance of independent 3â UTR RNA (referred as I3â UTR) was prompted by results of artificially introducing such RNA species into malignant mammalian cells. (omicsonline.org)
Malignant tumors of the major salivary glands can grow quickly, may be painful, and can cause loss of movement of part or all of the affected side of the face. (buildconenterprises.com)
Malignant brain and spinal cord tumors are likely to grow quickly and spread into other brain tissue. (kaiserpermanente.org)
Both benign and malignant brain tumors cause signs and symptoms and need treatment. (kaiserpermanente.org)
The area of research for our group is malignant lymphomas - all possible aspects, aiming for the improvement of the quality of life and survival of these patients. (lu.se)

Bevacizumab (Avastin) is a recombinant humanized monoclonal antibody that binds vascular endothelial growth factor (VEGF) and prevents its stimulation of blood vessels in the tumor. (pulmccm.org)
Tumor vascular perfusion parameters obtained by using CT or MR perfusion have been used for tumor grading, prognosis, and treatment response in addition to differentiating treatment/radiation effects and non-neoplastic lesions from neoplasms. (ajnr.org)
High-grade gliomas can be highly invasive and extremely vascular tumors. (ajnr.org)
3 - 5 However, PCT, which has also been used recently for glioma grading, 6 , 7 provides a linear relationship between tissue attenuation and tissue concentration of a contrast agent, unlike perfusion MR imaging, and, hence, probably provides a more robust and less biased estimation of hemodynamic (tumor blood volume) and physiologic (tumor vascular leakiness) parameters. (ajnr.org)
The phase III AURELIA trial demonstrated that the addition of the vascular endothelial growth factor (VEGF). (ascopost.com)
mTOR also reduces the cell growth factors (eg, vascular endothelial growth factor) involved in new blood vessel development. (medscape.com)

However, tumor cells can evade host's immune surveillance using a number of protective mechanisms, including downregulation of MHC-I molecules, secretion of anti-inflammatory cytokines, in other words, TGF-β and IL-10, secretion of immunosuppressive factors, VEGF, upregulation of PD-L1 and downregulation of co-stimulatory molecules thereby preventing activation of T cells, resulting in cancer invasion. (studylib.net)

Tumor immunotherapy brings substantial and long-term clinical benefits that can even cure tumors. (hindawi.com)
Tumor immunotherapy refers to novel therapeutic measures that turn the immune system into a destructive force against tumors [ 1 ]. (hindawi.com)
In recent years, tumor immunotherapy has achieved significant success in various cancers and has been one of the hotspots in the life sciences, especially immune checkpoint inhibitors and adoptive cellular therapy [ 3 ]. (hindawi.com)
The role of PD-1 and PD-L1 in T-cell immune suppression and the potential for immunotherapy via blocking PD-1 and PD-L1 in hematological malignancies are also reviewed. (biomedcentral.com)
Background The liver is a frequent site of metastases and liver metastases (LM) correlate with diminished immunotherapy efficacy in non-small cell lung cancer (NSCLC). (bmj.com)
This study aimed to analyze whether tumor response to immunotherapy differs between pulmonary lesions (PL) and LM in NSCLC and to explore potential mechanisms through multiomics analysis. (bmj.com)
Methods This observational longitudinal clinical cohort study included patients with NSCLC with LM receiving immunotherapy was conducted to evaluate organ-specific tumor response of PL and LM. (bmj.com)
Conclusions Compared with PL, LM presents an inferior organ-specific tumor response to immunotherapy. (bmj.com)
PL and LM showed limited heterogeneity in the genomic landscape, while the LM tumor microenvironment displayed lower levels of immune activation and infiltration than PL, which might contribute to developing precise immunotherapy strategies for patients with NSCLC with LM. (bmj.com)
Although immunotherapy using tumor infiltrating cells (TIL) or vaccine treatment have been expected as a promising modality to treat cancer, recent reports have indicated several mechanisms in tumor tissues to protect cancer cells from immune attacks [ 10 ]. (biomedcentral.com)
Conclusion: For immunotherapy/vaccines to be successful, the expression of PD-L1/PD-1 on immune cells should be considered, and the combination of checkpoint inhibitors and vaccines may pave the way for successful outcomes to disease. (studylib.net)

In view of the wider availability, faster scanning times, and low cost compared with MR perfusion, PCT is potentially well-suited to study brain tumors 6 , 7 and could potentially be useful as an easy tool for quantitative estimates of perfusion parameters and their use as imaging biomarkers. (ajnr.org)
Molecular characterization and Biomarkers are becoming increasingly important in the management of HGG especially with respect to anaplastic glioma (AG) that have refined prognosis and increasingly are predictive with respect to treatment. (surgicalneurologyint.com)

It can be recognized by a constant expression of the tumour receptor necrosis factor CD30, a membrane protein expressed by activated T and B cells, in the cancer cells. (wikipedia.org)
Various dermatological conditions have been reported during tumor necrosis factor (TNF)-α-blocking therapy, but until now no prospective studies have been focused on this aspect. (biomedcentral.com)

Chemotherapy, drugs, autologous stem cell treatment and extracorporeal photopheresis are treatment options. (wikipedia.org)
For too long, treatment for advanced non-small cell lung cancer was brutally simple: platinum chemotherapy and a trip to the attorney to get one's affairs in order. (pulmccm.org)
Effective targeted molecular therapies for non-small cell lung cancer are now available, often taken orally with fewer side effects than traditional cytotoxic chemotherapy. (pulmccm.org)
Only a minority of non-small cell lung cancers express mutations that make them vulnerable to the best targeted chemotherapy drugs. (pulmccm.org)
In a large randomized trial in patients with advanced NSCLC who had PD-L1 expressed on at least half of tumor cells, pembrolizumab was associated with longer survival and fewer serious side effects than traditional platinum-based chemotherapy. (pulmccm.org)
Adjuvant chemotherapy with PCV (procarbazine [Matulane], lomustine [CeeNU], and vincristine) following standard radiation therapy delayed disease progression and increased survival in patients with a relatively rare type of brain tumor called anaplastic oligodendroglioma. (ascopost.com)
The term chemotherapy has come to connote non-specific usage of intracellular poisons to inhibit mitosis (cell division) or induce DNA damage, which is why inhibition of DNA repair can augment chemotherapy. (worldsbest.rehab)
To a large extent, chemotherapy can be thought of as a way to damage or stress cells, which may then lead to cell death if apoptosis is initiated. (worldsbest.rehab)
Many of the side effects of chemotherapy can be traced to damage to normal cells that divide rapidly and are thus sensitive to anti-mitotic drugs: cells in the bone marrow, digestive tract and hair follicles. (worldsbest.rehab)
This results in the most common side-effects of chemotherapy: myelosuppression (decreased production of blood cells, hence also immunosuppression), mucositis (inflammation of the lining of the digestive tract), and alopecia (hair loss). (worldsbest.rehab)
Because of the effect on immune cells (especially lymphocytes), chemotherapy drugs often find use in a host of diseases that result from harmful overactivity of the immune system against self (so-called autoimmunity). (worldsbest.rehab)
Dosage of chemotherapy can be difficult: If the dose is too low, it will be ineffective against the tumor, whereas, at excessive doses, the toxicity (side-effects) will be intolerable to the person receiving it. (worldsbest.rehab)

Bennett J, Baumgarten SC, Stocco C. GATA4 and GATA6 Silencing in Ovarian Granulosa Cells Affects Levels of mRNAs Involved in Steroidogenesis, Extracellular Structure Organization, IGF-I Activity, and Apoptosis. (chicagobiomedicalconsortium.org)
This may be secondary to a germinal center origin or attributable to increased apoptosis via induction of bax and/or enhanced T-cell interaction, resulting in improved autologous tumor response. (aacrjournals.org)
Murine PD-1 mRNA expression has been shown to be correlated with activation-induced apoptosis in a mouse T-cell hybridoma cell line and murine thymocytes [ 13 ]. (biomedcentral.com)
Knockdown of KDM1B inhibits cell proliferation and induces apoptosis of pancreatic cancer cells. (cancerindex.org)
The antibody is useful for studying the phenomenon of cell death by apoptosis as a pathogenic mechanism of numerous pathologies: nerve damage, neurodegenerative diseases, cardiovascular diseases, autoimmune diseases, AIDS and malignancies. (samatashkhis.com)
An aberrant miRNA expression could contribute to cancer development and progression [ 6 , 7 ] and could affect their target genes that are involved in many biological processes, such as cell differentiation, proliferation, apoptosis, metabolism, and development [ 8 ]. (hindawi.com)
In contrary, tumor cells have evolved immune escape mechanisms whereby overexpression of PD-L1 induces anergy and/or apoptosis of PD-1 positive T cells by interfering with T cell receptor signal transduction. (studylib.net)
The binding of T cells expressing PD-1 and tumor cells expressing PD-L1 initiates an array of inhibitory signals resulting in reduced function and/or apoptosis of T cells [8,11] providing a mechanism for tumor cell evasion of host's immune surveillance [12-14]. (studylib.net)

T-cell activation and dysfunction relies on direct and modulated receptors. (biomedcentral.com)
NOTCH1, NOTCH2, NOTCH3 and NOTCH4 are cell surface receptors that transduce juxtacrine signals of delta-like canonical Notch ligand (DLL)1, DLL3, DLL4, jagged canonical Notch ligand (JAG)1 and JAG2 from adjacent cells ( 1 - 3 ). (spandidos-publications.com)

Ma Z, Gibson SL, Byrne MA, Zhang J, White MF and Shaw LM (2006) Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis. (scielo.br)
Dissemination of medulloblastoma within cerebrospinal fluid (CSF) pathways is a defining pathobiologic characteristic of this tumor, and about 30% of patients will have CSF metastasis at presentation. (medscape.com)
All patients with advanced NSCLC should have biopsy specimens of their primary tumor or a metastasis tested for the presence of a so-called driver mutation. (pulmccm.org)
Some of the patients can be treated with ablative doses of radiation if the tumor is less than 5 cm and without lymph node metastasis. (encyclopedia.pub)
Due to the insidious identity of HCC, the majority of the patients are diagnosed at advanced stages, where tumor spreading, or distant metastasis unfortunately have already occurred. (stanford.edu)

We sequenced the coding regions surrounding YXXM motifs of IRS1 using tumor samples of 42 NSCLC patients and 40 matching controls and found heterozygote p.S668T mutation in nine of 42 samples and four of nine also had the p.D674H mutation. (scielo.br)
Lung cancer is divided into two major groups: non small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). (scielo.br)
Pembrolizumab (Keytruda), a humanized monoclonal anti-PD-1 antibody, is the first anti-PD-1 antibody approved by the FDA for the treatment of patients with unresectable or metastatic melanoma, non-small-cell lung cancer (NSCLC), head and neck squamous cell carcinoma, cervical cancer, colorectal cancer, and gastric/gastroesophageal junction cancer [ 4 - 10 ]. (hindawi.com)
The new treatments are in no way cures, but they can prolong survival and improve quality of life with advanced (stage IIIB and IV) non-small cell lung cancer (NSCLC). (pulmccm.org)
About a quarter of patients with NSCLC have tumors that express high levels of programmed death ligand (PD-L1). (pulmccm.org)
Lung cancer is divided to Non-Small Cell Lung Cancer (NSCLC) comprising about 85% of lung cancer cases, and small cell lung cancer (15% of lung cancer cases). (encyclopedia.pub)
Non-small cell lung cancer (NSCLC) has several subtypes: a. (encyclopedia.pub)
Lung cancer is the leading cancer killer in both men and women in the Unites States, with over 135,000 deaths expected during 2020 [ 1 ] Small cell lung cancer accounts for 15%, and non-small cell lung cancer (NSCLC) for 85% of lung cancer cases [ 2 ] . (encyclopedia.pub)
Lung cancer includes two main types: non-small cell lung cancer (NSCLC) and small-cell lung cancer (SCLC). (medpagetoday.com)
NSCLC is any type of epithelial lung cancer other than small cell lung cancer and is the cause of approximately 85% of lung cancers. (medpagetoday.com)
The most common types of NSCLC are squamous cell carcinoma, large cell carcinoma, and adenocarcinoma, but there are several other types that occur less frequently, and all types can occur in unusual histologic variants. (medpagetoday.com)
Furthermore, upregulation of PD-L1 by cancer cells results in cancer invasion and correlates with poor prognostic outcomes in breast, gastric, meningioma, non-small-cell lung carcinoma (NSCLC) and soft-tissue sarcoma patients [9,26-29]. (studylib.net)
There are two clinical types of lung cancer: non-small cell lung carcinoma (NSCLC), which accounts for 85% of all cases, and small cell lung carcinoma (SCLC) [ 1 , 3 ]. (oncotarget.com)

METHODS: We asked whether host stromal senescence after CDK4/6 inhibition affects metastatic seeding and growth of CDKi-resistant mammary cancer cells by using the p16-INK-ATTAC mouse model of inducible senolysis. (bvsalud.org)
The most potent nanobody-based CAR-T cells show inhibition of large tumor xenografts in mice with rigorous T-cell signaling and significant T-cell infiltration into the tumor. (nature.com)
This may include oncomir (oncogenic miRNA) inhibition, or tumor suppressor-miRNA replacement therapies [ 6 , 9 ]. (hindawi.com)

Histologic evaluation of tumor angiogenesis by using various markers such as MVD, MVCP, and TVA is also limited by this regional heterogeneity, and its confounding effect is worsened by its small size and a limited number of samples obtained with surgical biopsy. (ajnr.org)

There are many different subtypes under mature T-cell lymphoma, each being considered as a separate disease due to specific clinical features. (wikipedia.org)
[ 1 ] These tumors display considerable clinical and biologic heterogeneity, and they have been further defined molecularly and histologically. (medscape.com)
Hence, there is a need for noninvasive in vivo clinical imaging tools that can study perfusion in the entire tumor, can be used to assess much larger volumes than small biopsy samples, and can probably guide biopsy and excision sites for better results. (ajnr.org)
Merck and Eisai are studying the KEYTRUDA plus LENVIMA combination through the LEAP (LEnvatinib And Pembrolizumab) clinical program in various tumor types, including but not limited to endometrial carcinoma, hepatocellular carcinoma, RCC, head and neck cancer, gastric cancer and esophageal cancer across multiple clinical trials. (streetinsider.com)
Phase III clinical trials of Rova‑T for patients with small‑cell lung cancer and a phase III clinical trial of nirogacestat for patients with desmoid tumors are ongoing. (spandidos-publications.com)
Computed tomography-based tumor volume in non-Hodgkin lymphoma: clinical correlation and comparison with magnetic resonance imaging. (medscape.com)
In the past decade, many clinical trials have been investigating anti-CTLA-4 as well as anti-programmed cell death protein 1 (PD-1) therapies in various solid tumors, including HCC. (stanford.edu)
although it is derived from cells of the renal tubular epithelium, it has several histological subtypes which differ in their clinical outcome and biological features. (hindawi.com)
2. Clinical epidemiology - using data from the Swedish Lymphoma Registry to provide clinically useful real world data on treatment and prognosis, in many cases in collaboration with Nordic colleagues. (lu.se)

In solid tumors, the B7-H3 transmembrane protein is an emerging target that harbours two distinct epitope motifs, IgC and IgV, in its ectodomain. (nature.com)
However, the successful application of these emerging cell-based therapies in solid tumors remains limited. (nature.com)
Her research interest focuses on the molecular oncology and immunotherapies of solid tumors and she published more than 40 peer reviewed papers. (stanford.edu)
Objective: This systemic review and meta-analysis focuses on the prognostic value of p53 Abs expressed in the serum of patients with solid tumors. (stanford.edu)
Main Outcome(s) and Measure(s): The primary study outcome was to determine the prognostic value of p53 Abs from a large population of patients with solid tumors, as determined before data collection. (stanford.edu)

In conclusion, ANCO1 has hallmarks of a tumor suppressor whose loss of expression activates breast-cancer-specific enhancers and oncogenic pathways that can accelerate the early-stage progression of breast cancer. (bvsalud.org)
Importance: The protein p53 is an unequivocal tumor suppressor that is altered in half of all cancers. (stanford.edu)

The complexity of new molecular targeted therapies is upsetting the apple cart of established treatment protocols for advanced non-small cell lung cancer - and that's a good thing. (pulmccm.org)
Several molecular alterations found in carcinoid tumors might act as molecular targets leading to development of new therapeutic options. (springeropen.com)

Mature T-cell lymphoma is under the category of non-Hodgkin lymphoma. (wikipedia.org)
Humanized anti-CD123 antibody facilitates NK cell antibody-dependent cell-mediated cytotoxicity (ADCC) of Hodgkin lymphoma targets via ARF6/PLD-1. (rndsystems.com)
Zhang QY, Foucar K. Bone marrow involvement by Hodgkin and non-Hodgkin lymphomas. (medscape.com)
Hodgkin lymphoma with cutaneous involvement. (medscape.com)
Adult Non-Hodgkin Lymphoma Treatment (PDQ®): Health Professional Version. (medscape.com)
Follicular non-Hodgkin lymphoma grades 3A and 3B have a similar outcome and appear incurable with anthracycline-based therapy. (medscape.com)
Cancer Stat Facts: Non-Hodgkin Lymphoma. (medscape.com)
Time trends in risk and risk determinants of non-hodgkin lymphoma in solid organ transplant recipients. (medscape.com)
Serum Levels of the Chemokine CXCL13, Genetic Variation in CXCL13 and Its Receptor CXCR5, and HIV-Associated Non-Hodgkin B-Cell Lymphoma Risk. (medscape.com)

3 Most gliomas, especially high-grade ones, show a high degree of regional heterogeneity within the tumor based on tumor cellularity, edema, and necrosis. (ajnr.org)

Some subtypes of mature T-cell lymphoma may be associated with viral exposure as well as gene mutations. (wikipedia.org)
Mature T-cell lymphoma can be associated with viral exposure and gene mutations. (wikipedia.org)
As additional drugs are developed targeting the known mutations, that proportion is growing -- along with the costs of treating advanced non-small cell lung cancer. (pulmccm.org)
Many patients with advanced non-small cell lung cancer harbor other driver mutations for which no drug has yet been approved for lung cancer treatment by the FDA. (pulmccm.org)
Loss‑of‑function NOTCH1 mutations are early events during esophageal tumorigenesis, whereas gain‑of‑function NOTCH1 mutations are late events during T‑cell leukemogenesis and B‑cell lymphomagenesis. (spandidos-publications.com)
Genomic landscapes profiling revealed similar somatic mutations, tumor mutational burden, and neoantigen number between PL and LM. (bmj.com)

Mature T-cell lymphoma, also called peripheral T-cell lymphoma, is a group of rare, aggressive lymphomas that develop from mature white blood cells and originate from lymphoid tissues outside of the bone marrow. (wikipedia.org)
Here we analyzed cell-free, methylated DNA released from dying cells into the circulation to evaluate radiation-induced cellular damage in different tissues. (bvsalud.org)
To map the circulating DNA fragments to human and mouse tissues, we established sequencing-based, cell-type-specific reference DNA methylation atlases. (bvsalud.org)
Strikingly, patients treated for right-sided breast cancers also showed increased hepatocyte and liver endothelial DNA in the circulation, indicating the impact on liver tissues. (bvsalud.org)
Thus, changes in cell-free methylated DNA can uncover cell-type-specific effects of radiation and provide a readout of the biologically effective radiation dose received by healthy tissues. (bvsalud.org)
Developing top down proteomics to maximize proteome and sequence coverage from cells and tissues. (chicagobiomedicalconsortium.org)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
An adult central nervous system tumor is a disease in which abnormal cells form in the tissues of the brain and/or spinal cord. (kaiserpermanente.org)

2004) Akt phosphorylation and gefitinib efficacy in patients with advanced non-small-cell lung cancer. (scielo.br)
Non-Small Cell Lung Cancer" Encyclopedia , https://encyclopedia.pub/entry/3438 (accessed December 11, 2023). (encyclopedia.pub)
Notch signaling is aberrantly activated in breast cancer, non‑small‑cell lung cancer and hematological malignancies, such as T‑cell acute lymphoblastic leukemia and diffuse large B‑cell lymphoma. (spandidos-publications.com)
However, Notch signaling is inactivated in small‑cell lung cancer and squamous cell carcinomas. (spandidos-publications.com)
By contrast, somatic alterations in the genes encoding Notch signaling components drive various types of human cancer, such as breast cancer, small-cell lung cancer (SCLC) and T-cell acute lymphoblastic leukemia (T-ALL) ( 6 - 9 ). (spandidos-publications.com)
The second group includes large cell neuroendocrine carcinoma (LCNEC) and small cell lung cancer (SCLC). (springeropen.com)
Here, we show that an increase in the levels of GPR171 is crucial for lung cancer tumor progression in vitro and in vivo . (oncotarget.com)
Knockdown of GPR171 also inhibited migration and invasion of the lung cancer cell lines. (oncotarget.com)
Up to half of metastatic brain tumors are from lung cancer. (kaiserpermanente.org)

It is characterised by systemic disorders, polymorphous lymphoid infiltrate and a significant increase in proliferation of follicular dendritic cells and high endothelial venules. (wikipedia.org)
Also, our mutants induced proliferation, glucose uptake, inhibited the migration of 293T cells and affected the responsiveness of the cells to cisplatin and radiation. (scielo.br)
Such immune dysfunction may be due to a disorder in thymic output function (in particular in young patients), which results in a lower level of naive T-cells in the peripheral blood available for an immune response to the proliferation and abnormal expression of the T cell receptor (TCR) repertoire. (biomedcentral.com)
miR-381-3p inhibits HCC cell proliferation, invasion and migration and may be a new therapeutic target for HCC. (nobleresearch.org)
Depletion of GPR171 with an anti-GPR171 antibody decreased proliferation of lung carcinoma cells and attenuated tumor progression in a mouse xenograft model. (oncotarget.com)

It originates from follicular T helper (TFH) cells, which is important in maintaining immune response. (wikipedia.org)
Metz H, Busch SE, Hanke ML, Kargl J, Kim KH and Houghton M (2014) Insulin receptor substrate-1 regulates immune cell content in lung adenocarcinoma. (scielo.br)
Immune checkpoint inhibitors (ICIs) are antibodies that target crucial signaling pathways, such as programmed death 1 (PD-1)/programmed death-ligand 1 (PD-L1), and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), to improve the activation of T cells and enhance the immune response to cancer cells. (hindawi.com)
Adoptive cellular therapy transmits the sensitized T cells to patients with low cellular immune function, which helps patients obtain antitumor immunity. (hindawi.com)
Moreover, increasing data have shown that peripheral T-cell tolerance is an essential property of the specific immune response to tumor cells. (biomedcentral.com)
Rational design of chimeric antigen receptor T (CAR-T) cells based on the recognition of antigenic epitopes capable of evoking the most potent CAR activation is an important objective in optimizing immune therapy. (nature.com)
An oncoantigen was defined as a molecule with high immunogenicity in our immune system and with oncogenic function that plays a critical role in the growth of tumor cells. (biomedcentral.com)
However, for cancer prevention, the elimination or inactivation of mutated cells is debated on whether this is a prime function of the immune system. (studylib.net)
Their theory concurred with studies by Doherty and Zinkernagel, where they demonstrated that the immune system plays an essential role in immune surveillance by recognizing small peptide epitopes in conjunction with the MHC-I presented on the surface of virus infected cells [5]. (studylib.net)
Consequently, it was shown by others that tumor cells also expressed MHC-I and presented short tumor-associated peptides to immune cells [6]. (studylib.net)

This study aimed to clarify the role of mesenchymal stem cells (MSCs) as a component of the cancer microenvironment. (cancerindex.org)
Notch signaling cascades crosstalk with fibroblast growth factor and WNT signaling cascades in the tumor microenvironment to maintain cancer stem cells and remodel the tumor microenvironment. (spandidos-publications.com)

Squamous cell carcinoma, c. (encyclopedia.pub)
Large cell carcinoma, or d. mixed histology. (encyclopedia.pub)
Overall survival was statistically superior for cisplatin/pemetrexed versus cisplatin/gemcitabine in patients with adenocarcinoma and large-cell carcinoma histology, while patients with squamous cell histology had a significant improvement in survival with cisplatin/gemcitabine versus cisplatin/pemetrexed [ 81 ] . (encyclopedia.pub)
KEYTRUDA plus LENVIMA is approved in the U.S., the EU, Japan and other countries for the treatment of advanced renal cell carcinoma (RCC) and certain types of advanced endometrial carcinoma. (streetinsider.com)
Renal cell carcinoma (RCC) incidence has increased over the past two decades. (hindawi.com)
Renal cell carcinoma (RCC) accounts for approximately 3% of human malignancies, and its incidence appears to be increasing globally [ 1 ]. (hindawi.com)
and large cell carcinoma (5-15% of all lung cancers) [ 4 , 5 ]. (oncotarget.com)

The analysis of serum samples from patients with breast cancer undergoing radiation treatment revealed distinct dose-dependent and tissue-specific epithelial and endothelial responses to radiation across multiple organs. (bvsalud.org)
It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. (cancerindex.org)

AIB1 itself is an oncogene that is overexpressed in a subset of breast cancers and is known to play a role in tumor progression and resistance to endocrine therapy through multiple mechanisms. (bvsalud.org)
Moreover, T cell function becomes suppressed with disease progression. (biomedcentral.com)

Adoptive cellular therapy, especially chimeric antigen receptor (CAR) T cell therapy, has gained unprecedented success among hematologic tumors [ 11 ]. (hindawi.com)
Our results highlight the importance of the specific target antigen epitope in governing optimal CAR-T activity and provide a nanobody-based B7-H3 CAR-T product for use in solid tumor therapy. (nature.com)
Small-molecule inhibitors, antagonistic monoclonal antibodies (mAbs), antibody-drug conjugates (ADCs), bispecific antibodies or biologics (bsAbs) and chimeric antigen receptor-modified T cells (CAR-Ts) targeting Notch signaling components have been developed as investigational anti-cancer drugs ( 10 - 12 ). (spandidos-publications.com)
The antigen processing and presentation, natural killer (NK) cell-mediated cytotoxicity and T-cell receptor signaling pathway were enriched in PL compared with LM. (bmj.com)

Symptoms specific to subtypes include diffuse lymphadenopathy and hepatosplenomegaly in AITL, and swellings in skin in cutaneous T-cell lymphoma. (wikipedia.org)
Abstract B38: FOXP1 truncated isoforms differentially regulate target genes in diffuse large B cell lymphoma. (growkudos.com)
In search for subgroups of diffuse large B-cell lymphoma (DLBCL) with different histogenetic origin and prognosis, as has been described by gene expression profiling, we examined tumor specimens from 125 patients with DLBCL, uniformly treated by either cyclophosphamideAdriamycin-vincristine-prednisone or methotrexate, doxorubicin, cyclophosphamide, vincristine, prednisone, and bleomycin in a multicenter trial set by the Nordic Lymphoma Group 1989-1994. (aacrjournals.org)
The first-in-human testing of scFv-based B7-H3 CAR-T cells has shown antitumor response against anaplastic meningioma and childhood diffuse intrinsic pontine glioma without severe side effects 16 , 17 . (nature.com)
Neuroendocrine neoplasms (NENs) include all tumors derived from the diffuse endocrine system. (springeropen.com)

In vivo perfusion imaging techniques provide additional information regarding tumor physiology and hemodynamics, which may help in better characterizing glioma malignancy and may also overcome some of the limitations of histologic grading and conventional morphologic imaging. (ajnr.org)

We investigated the homing-related chemokine expression levels of MSCs treated with a prostate cancer cell line (PC-3) -conditioned medium. (cancerindex.org)
In addition, the low cytotoxicity of T-cells may be related to the high expression level of inhibitory molecules including programmed death-1 (PD-1), LAG-3 and NKG2A in CD8+T cells [ 11 ]. (biomedcentral.com)
Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. (cancerindex.org)
and cell differentiation ( SOX2 and TGFB3 ) as well as immunohistochemical assay for VEGFA, TP53, Bcl2, TGFB1, and Ki67 protein expression have been performed in 85 FFPE RCC tumor specimens. (hindawi.com)
[email protected] ‡ Authors contributed equally Aim: Expression of PD-1 on T/B cells regulates peripheral tolerance and autoimmunity. (studylib.net)

A tumor that starts in another part of the body and spreads to the brain is called a metastatic brain tumor. (kaiserpermanente.org)
These are called metastatic brain tumors (or brain metastases). (kaiserpermanente.org)
Metastatic brain tumors are more common than primary brain tumors. (kaiserpermanente.org)

BOB.1 from "B cell binding Octamer protein 1 "is a specific coactivator of transcription factors Oct-1 and Oct-2 of B lymphocytes. (samatashkhis.com)
MEN1 maps on chromosome 11 and encodes for menina, a nuclear protein involved in cell replication, DNA repair and transcription process. (springeropen.com)

The overall effectiveness ranges from being curative for some cancers, such as some leukemias, to being ineffective, such as in some brain tumors, to being needless in others, like most non-melanoma skin cancers. (worldsbest.rehab)

Apparent diffusion coefficient (ADC) map of a histologically confirmed medulloblastoma showing restricted diffusion consistent with a tumor of high cellularity. (medscape.com)

Its common subtypes include angioimmunoblastic T-cell lymphoma, anaplastic large cell lymphoma and peripheral T-cell lymphoma not otherwise specified. (wikipedia.org)
The common subtypes are angioimmunoblastic T-cell lymphoma, anaplastic large cell lymphoma and peripheral T-cell lymphoma not otherwise specified. (wikipedia.org)
Peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) is a group of biologically and clinically heterogeneous lymphomas that do not fit into the other subtypes of mature T-cell lymphoma. (wikipedia.org)
About 30% of PTCL-NOS patients exhibit EBV-infected cancerous T cells, leading to the classification of Epstein-Barr virus-associated peripheral T cell lymphoma not otherwise specified. (wikipedia.org)

Based on their functional outcome, co-signaling molecules can be divided as co-stimulators and co-inhibitors, which positively and negatively control the priming, growth, differentiation and functional maturation of a T-cell response. (biomedcentral.com)

Medulloblastoma is defined by the World Health Organization (WHO) as "an embryonal neuroepithelial tumor arising in the cerebellum or dorsal brainstem, presenting mainly in childhood and consisting of densely packed small round undifferentiated cells with mild to moderate nuclear pleomorphism and high mitotic count. (medscape.com)

Angioimmunoblastic T-cell lymphoma (AITL) is a fast-growing form of mature T-cell lymphoma, accounting for 18.5% of patients. (wikipedia.org)
Anaplastic large cell lymphoma (ALCL) is a subtype of mature T-cell lymphoma involving T-cells or natural killer (NK) cells, representing 12% of patients. (wikipedia.org)
It is the most common subtype, representing 25.9% of mature T-cell lymphoma patients. (wikipedia.org)
Mature T-cell lymphoma is fast-growing and patients are usually diagnosed at later stage. (wikipedia.org)
Martí-Carvajal AJ, Cardona AF, Lawrence A. Interventions for previously untreated patients with AIDS-associated non-Hodgkin's lymphoma. (medscape.com)
Recently, the treatment of newly diagnosed anaplastic glioma (AG) has changed, particularly in patients with 1p19q codeleted tumors. (surgicalneurologyint.com)
Results of trials currenlty ongoing are likely to determine the best standard of care for patients with noncodeleted AG tumors. (surgicalneurologyint.com)

Less common subtypes of mature T-cell lymphoma include cutaneous T-cell lymphoma, adult T-cell leukaemia/lymphoma, enteropathy-type T-cell lymphoma, nasal NK/T-cell lymphoma, hepatosplenic gamma-delta T-cell lymphoma, etc. (wikipedia.org)
Signs and symptoms of mature T-cell lymphoma vary among different subtypes, sometimes even among individuals under the same subtype. (wikipedia.org)
Histologic subtypes of medulloblastoma include: (1) desmoplastic/nodular type, (2) medulloblastoma with extensive nodularity, and (3) large-cell/anaplastic medulloblastoma. (medscape.com)
1] Several subtypes of medulloblastoma have been recognized including: (1) desmoplastic/nodular type, (2) medulloblastoma with extensive nodularity, (3) large-cell variant, and (4) anaplastic medulloblastoma. (medscape.com)

Perfusion imaging has been used to assess tumor grade and prognosis and, recently, to assess treatment response, which has attracted more attention due to the advent of newer therapeutic options, including antiangiogenic agents. (ajnr.org)
Vitamin D insufficiency and prognosis in non-Hodgkin's lymphoma. (medscape.com)
The World Health Organization (WHO) classification of gliomas is used to define the type and grade of tumor, but the prognosis and response to treatment may vary among tumors even in the same subtype of tumor. (surgicalneurologyint.com)

Follicular lymphoma international prognostic index. (medscape.com)

In the present study, we demonstrate that B7-H3 CAR-T cells targeting the IgC domain are more active than those targeting the IgV domain in pancreatic ductal adenocarcinoma (PDAC) and neuroblastoma (NB) mouse preclinical models. (nature.com)

Somatic cell therapy is viewed as a more conservative, safer approach because it affects only the targeted cells in the patient, and is not passed on to future generations. (omicsonline.org)
Such single gene disorders are good candidates for somatic cell therapy. (omicsonline.org)

Stage IIIB tumors are of any size and have spread to lymph nodes on the other side of the chest, near the collarbone, or have invaded other structures in the chest such as the heart or esophagus. (medpagetoday.com)

The Notch signaling network exerts oncogenic and tumor‑suppressive effects in a cancer stage‑ or (sub)type‑dependent manner. (spandidos-publications.com)

Gliomas, the most common primary brain neoplasms in adults, are very heterogeneous tumors. (ajnr.org)

Mol Cell Biol 26:9338-9351. (scielo.br)

Cancer Cell. (chicagobiomedicalconsortium.org)
Polydopamine-enabled surface functionalization of gold nanorods for cancer cell-targeted imaging and photothermal therapy. (chicagobiomedicalconsortium.org)
Mesenchymal stem cells up-regulate the invasive potential of prostate cancer cells via the eotaxin-3/CCR3 axis. (cancerindex.org)
Traditional chemotherapeutic agents are cytotoxic by means of interfering with cell division (mitosis) but cancer cells vary widely in their susceptibility to these agents. (worldsbest.rehab)
Through 1990â s to 2000â s, world scientists found several 3â UTR RNAs that functioned as artificial independent RNAs in cancer cells and resulted in tumor suppression. (omicsonline.org)
In fact, cancer cells, in particular renal and breast cells express high levels of PD-L1 leading to poor patient survival [15,16]. (studylib.net)

[ 4 ] Adult cases are unusual, accounting for less than 1% of brain tumors. (medscape.com)
Perfusion imaging of brain tumors has been performed by using various tracer and nontracer modalities and can provide additional physiologic and hemodynamic information, which is not available with routine morphologic imaging. (ajnr.org)
This article is an overview of the utility of PCT for assessment of brain tumors and describes the technique, its advantages, and limitations. (ajnr.org)
Traditionally, perfusion imaging of brain tumors has been performed with MR imaging, by using various perfusion imaging techniques and estimating tumor blood volume, blood flow, and permeability. (ajnr.org)
There are many types of brain and spinal cord tumors. (kaiserpermanente.org)
The tumors are formed by the abnormal growth of cells and may begin in different parts of the brain or spinal cord. (kaiserpermanente.org)
Benign brain and spinal cord tumors grow and press on nearby areas of the brain. (kaiserpermanente.org)
When a tumor grows into or presses on an area of the brain, it may stop that part of the brain from working the way it should. (kaiserpermanente.org)
Brain and spinal cord tumors can occur in both adults and children. (kaiserpermanente.org)
For information about lymphoma that begins in the brain, see the PDQ summary on Primary CNS Lymphoma Treatment. (kaiserpermanente.org)
Tumors that start in the brain are called primary brain tumors. (kaiserpermanente.org)
Primary brain tumors may spread to other parts of the brain or to the spine. (kaiserpermanente.org)
Often, tumors found in the brain have started somewhere else in the body and spread to one or more parts of the brain. (kaiserpermanente.org)
The cerebrum is the largest part of the brain. (kaiserpermanente.org)
Brain and spinal cord tumors are named based on the type of cell they formed in and where the tumor first formed in the CNS. (kaiserpermanente.org)
HN - 2008 MH - Superior Sagittal Sinus UI - D054063 MN - A07.231.908.224.667 MS - The long large endothelium-lined venous channel on the top outer surface of the brain. (bvsalud.org)

The presence of a subpopulation of ANCO1-depleted cells enabled invasion of the overall cell population in vitro and they converted more rapidly to invasive lesions in a xenograft mouse model. (bvsalud.org)

It is involved in p53 pathways and is implicated in cell death/survival signaling, the cell cycle, and differentiation, thereby playing a regulatory role in carcinogenesis [ 12 ]. (hindawi.com)

Moreover, it has been shown that the PD-1 ligand (PD-L1) is highly expressed in leukemia cells. (biomedcentral.com)
In addition, PD-1/PD-L1 interactions contribute to functional T-cell impairment, which fails to elicit minimal residual disease and may be related to leukemia relapse. (biomedcentral.com)

Anatomy30

Organisms8

Diseases65

Chemicals and Drugs65

Analytical, Diagnostic and Therapeutic Techniques and Equipment48

Phenomena and Processes47

Disciplines and Occupations1

Information Science5

Health Care7

Epidermal growth f5

Kinase8

Malignant14

Vascular6

VEGF1

Immunotherapy11

Biomarkers2

Necrosis factor2

Chemotherapy12

Apoptosis8

Receptors2

Metastasis5

NSCLC13

Inhibition3

Angiogenesis1

Clinical9

Solid tumors5

Suppressor2

Molecular2

Hodgkin9

Heterogeneity1

Mutations6

Tissues8

Lung Cancer9

Proliferation5

Immune10

Microenvironment2

Carcinoma7

Epithelial2

Progression2

Antigen4

Diffuse5

Characterizing glioma1

Expression5

Metastatic3

Protein2

Cancers1

Cellularity1

Peripheral4

Inhibitors1

Embryonal1

Patients7

Subtypes4

Prognosis3

Follicular1

Adenocarcinoma1

Somatic2

IIIB1

Oncogenic1

Gliomas1

Biol1

Cancer6

Brain16

Invasive1

Pathways1

Leukemia2