Drug DesignDrug Delivery SystemsModels, MolecularComputer-Aided DesignCell Line, TumorTumor Markers, BiologicalDelivery, ObstetricTumor BurdenTumor Necrosis Factor-alphaCrystallography, X-RayLigandsMolecular Docking SimulationStructure-Activity RelationshipBinding SitesProtein ConformationProtein BindingQuantitative Structure-Activity RelationshipMolecular Sequence DataDrug DiscoveryMolecular StructureNeoplasms, ExperimentalWilms TumorNeoplasmsAmino Acid SequenceTumor Suppressor Protein p53Research DesignTime FactorsGenes, Tumor SuppressorTreatment OutcomeCarcinoid TumorCystine Knot MotifsBrain NeoplasmsAntineoplastic AgentsProteinsDrug Evaluation, PreclinicalNeuroendocrine TumorsMolecular ConformationDrug CarriersDose-Response Relationship, DrugTumor Suppressor ProteinsPharmaceutical PreparationsPregnancyProtein Structure, TertiaryTumor MicroenvironmentCell ProliferationMutationNeovascularization, PathologicEnzyme InhibitorsMammary Neoplasms, ExperimentalComputer SimulationAlgorithmsChemistry, PharmaceuticalMice, Inbred BALB CSignal TransductionMolecular Dynamics SimulationCatalytic DomainXenograft Model Antitumor AssaysGenetic TherapyNeoplasm MetastasisCystine-Knot MiniproteinsNanoparticlesCell LineHydrogen BondingAdenocarcinomaTransplantation, HeterologousMice, Inbred C57BLStructural Homology, ProteinGene Transfer TechniquesModels, BiologicalSmall Molecule LibrariesProtein Structure, SecondaryModels, ChemicalRecombinant ProteinsCell SurvivalRetrospective StudiesGenetic VectorsComputational BiologyEquipment DesignPeptidesCyclotidesGastrointestinal Stromal TumorsThermodynamicsRNA, MessengerKineticsAntigens, NeoplasmDisease Models, AnimalCesarean SectionColonic NeoplasmsCell DivisionAntibodies, MonoclonalMice, NudeLiver NeoplasmsDelivery of Health CareBase SequenceSoftwareProspective StudiesCells, CulturedNeoplasm ProteinsTransfectionGlioma