MetastasisMetastases2017Malignant tumorsSolid tumors2018DiagnosisNeoplasmsEndometrial Stromal SarcomaPrognosisClinicalHistologicalLarger tumorsMetastaticFibrousEwing SarcomaNeuroectodermal tumorsAnti-tumourHuman tumourMesenchymal tumorsImmunohistochemistryNecrosisBenignExtraskeletalDiverse tumor typesRearrangementSuppressor genesCells2016MolecularChemotherapyHistologicVitroDiagnosticSoft tissue sarcomasInhibitionBrainUterineEwing'sCharacteristicHistiocyticWorld Health OrganCharacterizationResectionAngiosarcomaSurvivalEWSR12019PathwaySynovial sarcomasCancerSpecificityMalignancyChromosomalPathologicalGeneticallyClassificationLungChromosomeOncologySpindle cellHeterogeneousMaterial and MethodsSurgical
Metastasis12
- All of the 7 patients presented with primary tumors without distant metastasis. (biomedcentral.com)
- The action of antithymocyte serum on tumor growth and metatasis was investigated by using an experimental model of lymphatic metastasis after injection of murine uterine cervix carcinoma No.27 (U27) cells into the footpad of mice. (eurekamag.com)
- We hypothesize that a meta-analysis of publicly available gene expression datasets in various tumor types can identify a signature of metastasis that is common to multiple tumor types. (biomedcentral.com)
- It was therefore our hypothesis that there are common genes and pathways of metastasis shared by multiple cancer types, and that by expanding the above analysis to incorporate more or diverse tumor types, we would be able to identify more reliable genes and pathways involved in these common steps. (biomedcentral.com)
- Small satellite nodules separate from the main lesion are not uncommon, and 12% of patients may present with metastasis or locally recurrent tumors. (medscape.com)
- This is in contrast to other soft tissue sarcomas in which the lung is the most common site of metastasis. (medscape.com)
- If a tumor is large, metastasis is more likely to have occurred. (medscape.com)
- Via direct actions on cancer cells and indirect actions on the tumor microenvironment, radiation has the potential to enhance epithelial-to-mesenchymal transition, invasion, migration, angiogenesis and metastasis. (biomedcentral.com)
- Local invasion and distant metastasis are the cause of death in most malignant tumors. (biomedcentral.com)
- Malignant tumors consist of cancer cells and tumor-associated host cells, both participating in invasion and distant metastasis. (biomedcentral.com)
- One of the first molecules implicated in enhancement of distant metastasis after irradiation of the primary tumor was angiostatin, produced by the primary tumor and keeping metastasis dormant. (biomedcentral.com)
- Hypoxia stimulates hypoxia inducible factor (HIF)-dependent expression of CXCL12 and KITL promoting mobilization from the bone marrow and recruitment to primary tumor and metastatic sites of CXCR4 + CD11b + bone marrow-derived cells and KITbCD11b + cells assisting vasculogenesis and metastasis respectively (Kuonen et al. (biomedcentral.com)
Metastases9
- Lack of NKX2.2 expression in bronchopulmonary typical carcinoid tumors: implications for patients with neuroendocrine tumor metastases and unknown primary site. (nih.gov)
- A single-center study by DeVito et al found that malignant SFT, as compared with benign SFT, was associated with larger tumors, elevated mitotic counts, the presence of metastases at diagnosis, and more extensive use of chemotherapy and RT. (medscape.com)
- Crettenand F, Martin D, Cherix S, Demartines N, Matter M. Occurrence and prognosis of lymph node metastases in patients selected for isolated limb perfusion with soft tissue sarcoma. (jcancer.org)
- We identified 18 publicly available gene expression datasets in the Oncomine database comparing distant metastases to primary tumors in various solid tumors which met our eligibility criteria. (biomedcentral.com)
- We have modified a previously published meta-analysis method and identified a common metastatic signature by comparing primary tumors versus metastases in various tumor types. (biomedcentral.com)
- Uterine leiomyosarcoma (ULMS) and endometrial stromal sarcoma (ESS) are among the most frequent uterine sarcomas, which, in adults, lead to fatal lung metastases and patients have an extremely poor prognosis (Tsuyoshi and Yoshida 2018 ). (biomedcentral.com)
- Zheng ZD, Meng H. Alveolar soft part sarcoma with lung metastases: a case report[J]. Chin J Magn Reson Imaging, 2020, 11(11): 1038-1039. (med-sci.cn)
- Metastatic cancer cells are released from the primary tumor or from other metastases, at an undefined moment of its development, to arrive in the circulation and home at distant sites, where the ecosystem permits them to survive and either remain dormant as micro-metastases or grow to form macro-metastases (Mareel et al. (biomedcentral.com)
- Elimination of the primary tumor, either by irradiation or by surgery, shifts the balance towards pro-angiogenesis and growth of the lung metastases (Table 1 ) (Camphausen et al. (biomedcentral.com)
20172
- Brain metastatic alveolar soft-part sarcoma: Clinicopathological profiles, management and outcomes[J]. Oncol Lett, 2017, 14(5): 5779-5784. (med-sci.cn)
- Clinical sarcoma research 2017 7 8. (cdc.gov)
Malignant tumors1
- SFTs are malignant tumors of mesenchymal origin that occur in the extremities. (medscape.com)
Solid tumors2
- Approximately 1%-2% of solid tumors are soft-tissue sarcomas, and leiomyosarcomas comprise roughly 2%-9% of these sarcomas. (medscape.com)
- With improvements in response rates in solid tumors, opportunities have arisen to enhance the effectiveness of surgery. (intechopen.com)
20182
- Alveolar soft part sarcoma: clinical presentation, treatment, and outcome in a series of 13 patients[J]. J Chin Med Assoc, 2018, 81(8): 735-741. (med-sci.cn)
- Molecular landscape in alveolar soft part sarcoma: implications for molecular targeted therapy[J]. Biomedecine Pharmacother, 2018, 103: 889-896. (med-sci.cn)
Diagnosis17
- The patient was referred to neurosurgery after confirming the diagnosis and because of intracranial invasion of the tumour. (scitechnol.com)
- Although the presence of a t(X;18) rearrangement or expression of TLE1 can help confirm the diagnosis of synovial sarcoma, negative results for these tests are not diagnostic of malignant peripheral nerve sheath tumor. (eurekamag.com)
- Therefore, SOX10 is a specific (93%), albeit not very sensitive (67%), diagnostic marker to support a diagnosis of malignant peripheral nerve sheath tumor over synovial sarcoma. (eurekamag.com)
- In this article, the authors provide an overview of current concepts of clinicopathologic characteristics, specific molecular diagnosis, and general treatment strategies for these rare embryonal tumors of childhood. (medlink.com)
- Recent advances in the molecular diagnosis and treatment of pineoblastoma, a rare embryonal tumor of the pineal gland with particular penetrance in infants and young children, are also highlighted in this review. (medlink.com)
- Due to their rarity and heterogeneity, the accuracy of sarcoma diagnosis remains challenging. (frontiersin.org)
- In the diagnosis of sarcomas, tumor cell morphology (shape, pattern of growth, microenvironment contexture) and the expression of differentiation markers represent the most important factors, but molecular investigations are increasingly employed to complement these pathological assessments. (frontiersin.org)
- Indeed, the identification of histotype-specific (pathognomonic) gene alterations is of paramount importance in the differential diagnosis among sarcoma variants, between malignant and benign mimics, as well as between sarcoma and other tumor types ( 1 - 3 ). (frontiersin.org)
- Diagnosis, prognosis, and treatment of alveolar soft-part sarcoma: a review[J]. JAMA Oncol, 2019, 5(2): 254-260. (med-sci.cn)
- Cytopathological diagnosis of alveolar soft part sarcoma, a rare soft tissue neoplasm[J]. Cytopathology, 2011, 22(5): 318-322. (med-sci.cn)
- Despite the fact that all tumors have clear histological and immunological criteria, their diagnosis can be difficult, given the fact that there are overlapping variants of the morphological picture and immunophenotype both within the group and with other round cell tumors. (bvsalud.org)
- CONCLUSION: For the differential diagnosis of undifferentiated round-cell sarcomas, it is necessary to take into account the clinical, morphology when compared with the data of the IHC study, and verification by molecular genetic methods is necessary to improve the accuracy of diagnosis. (bvsalud.org)
- Formulation of a pathological diagnosis of CIC-rearranged sarcoma was initially supported by fluorescence in situ hybridisation findings and later validated by next-generation sequencing, which showed CIC-DUX4 gene fusion. (bvsalud.org)
- The occurrence of this tumor in the heart has been described only in a few publications in dogs, and such a multiple heart RMS as presented below is an extremely uncommon diagnosis not only in veterinary but also in human medicine. (biomedcentral.com)
- Rarity and heterogeneity of liposarcomas (LPS) make their diagnosis difficult even for sarcoma-experts pathologists. (biomedcentral.com)
- Although CNAs varied widely, the subtypes of tumors have characteristic genomic profiles that could facilitate the differential diagnosis of LPS subtypes, especially between WDLPS and DDLPS. (biomedcentral.com)
- However, the differential diagnosis between WDLPS and DDLPS is much more challenging, because about 10% of DDLPS are the recurrences of WDLPS as a non-lipogenic sarcoma of variable histological grade. (biomedcentral.com)
Neoplasms5
- Experimentally induced neoplasms of CONNECTIVE TISSUE in animals to provide a model for studying human SARCOMA. (curehunter.com)
- The term solitary fibrous tumor (SFT) is favored by soft-tissue pathologists to describe a rare, heterogeneous group of benign and malignant neoplasms along a morphologic continuum. (medscape.com)
- Brain tumors may be congenital in children younger than 3 years of age and range from benign complex lesions to highly malignant neoplasms. (medlink.com)
- CIC-rearranged sarcomas are rare mesenchymal neoplasms belonging to the family of undifferentiated small round cell sarcomas. (bvsalud.org)
- Heart tumors (HT) are uncommon in companion animals, accounting for roughly 0.2% of all neoplasms. (biomedcentral.com)
Endometrial Stromal Sarcoma2
- Morphologic distinction between uterine leiomyosarcoma (ULMS) and endometrial stromal sarcoma (ESS) alone is not straightforward and has been shown to be challenging especially with poor differentiation, so immunohistochemistry (IHC) is often employed as an adjunct to morphology in uterine sarcoma. (biomedcentral.com)
- The unique chromosomal rearrangements of endometrial stromal sarcoma (ESS) make it possible to distinguish high-grade ESS (HGESS) and low-grade ESS (LGESS) from the molecular perspective. (e-crt.org)
Prognosis3
- Conventional HPCs and SFTs have a better prognosis than some older studies may suggest, in that these studies may have inadvertently included sarcomas with HPC-like features. (medscape.com)
- Solitary fibrous tumors (SFTs) must be carefully distinguished from other entities, such as synovial sarcoma and angiosarcoma, which have a worse prognosis and different treatment course. (medscape.com)
- Uterine sarcoma accounts for 3-7% of all primary uterine malignancies which carry a poor prognosis (Barral et al. (biomedcentral.com)
Clinical5
- We present two clinical cases of patients aged 36 and 74 with an orbital solitary fibrous tumour (SFT). (scitechnol.com)
- Dedifferentiated chondrosarcoma is an aggressive mesenchymal tumor of the bone, and novel therapies are needed to improve its clinical outcomes. (cancer-genetics.org)
- Clinical signs depend primarily on the location of the tumor and its effect on blood flow. (biomedcentral.com)
- Clinical signs and their severity depend on the type, location, and size of the tumor. (biomedcentral.com)
- Liposarcomas (LPS), the most common soft tissue sarcomas accounting for less than 1% of all human cancer cases, display remarkable clinical and pathological heterogeneity. (biomedcentral.com)
Histological1
- ULMS is the most common histological subtype of uterine sarcoma originating in the smooth muscles of the myometrium. (biomedcentral.com)
Larger tumors1
- Logically, resection, which is the only hope for a cure, appears to be more difficult with larger tumors. (medscape.com)
Metastatic6
- Lymph node involvement was observed in 13 patients (N1, 23%), regarded as metastatic spreading in 4 angiosarcomas, 3 epithelioid sarcomas, 2 leiomyosarcomas, 2 undifferentiated sarcomas and 2 synovial sarcomas. (jcancer.org)
- Interestingly, all the genes in the signature, except one, were significantly down-regulated, suggesting that overcoming metastatic suppression may be a key feature common to all metastatic tumors. (biomedcentral.com)
- ULMS accounts for 60-70% of all uterine sarcoma and 1% of all uterine malignancies, but it is most dangerous due to their characteristic chemo-resistance and metastatic potential (Juhasz-Böss et al. (biomedcentral.com)
- iCREATE: imaging features of primary and metastatic alveolar soft part sarcoma from the EORTC CREATE study[J]. Cancer Imaging, 2020, 20(1): 79. (med-sci.cn)
- Yet, far less attention is paid to the effects of these treatments on tumor progression as reflected by the metastatic process. (biomedcentral.com)
- 2001 ). Molecular communication between ecosystems is also witnessed by the vasculogenic and pro-metastatic tumor bed effect as discussed by Kuonen et al. (biomedcentral.com)
Fibrous4
- Solitary fibrous tumor (SFT) was first described in 1870 by Wagner and further established in 1931 by Klemperer and Rabin as a pleural neoplasm. (medscape.com)
- Solitary fibrous tumour (SFT) is an uncommon neoplasm at the orbital level that behaves in benign way in most cases [ 1 ]. (scitechnol.com)
- Three patients had malignant fibrous histiocytoma, two patients had myxoid liposarcoma, one patient had synovial sarcoma, and one had extraskeletal chondrosarcoma. (biomedcentral.com)
- MRI of solitary fibrous tumor demonstrates a deep soft-tissue mass in the anteromedial aspect of the thigh with heterogenous high signal intensity on coronal STIR imaging. (medscape.com)
Ewing Sarcoma6
- NKX2.2 immunohistochemistry in the distinction of Ewing sarcoma from cytomorphologic mimics: Diagnostic utility and pitfalls. (nih.gov)
- Usefulness of NKX2.2 Immunohistochemistry for Distinguishing Ewing Sarcoma from Other Sinonasal Small Round Blue Cell Tumors. (nih.gov)
- Evaluation of NKX2-2 expression in round cell sarcomas and other tumors with EWSR1 rearrangement: imperfect specificity for Ewing sarcoma. (nih.gov)
- NKX2.2 is a useful immunohistochemical marker for Ewing sarcoma. (nih.gov)
- The tumor which bears his name is generally referred to as Ewing's sarcoma when spoken and either Ewing's sarcoma or Ewing sarcoma when written. (sarcomahelp.org)
- Pathologists have long known that Ewing sarcoma looks very similar to an even rarer soft tissue tumor called primitive neuroectodermal tumor ( PNET ). (sarcomahelp.org)
Neuroectodermal tumors2
- Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors. (tripod.com)
- The growth of human neuroectodermal tumors is inhibited in mice with severe combined immunodeficiency without any appreciable toxic effects on the animals. (tripod.com)
Anti-tumour2
- Molecular characterization of canine SHP2 mutants and anti-tumour effect of SHP2 inhibitor, SHP099 , in a xenograft mouse model of canine histiocytic sarcoma. (go.jp)
- This study examines the anti-tumour effects of di(2-ethylhexyl)phthalate (DEHP) isolated from Aloe vera Linne, in human and animal cell lines. (tripod.com)
Human tumour3
- ; IARC, human tumour sites. (who.int)
- For applications, including in the devel- but is required more simply to as- ease of reference, these five agents opment of human tumour profiles to sess the overall weight of the ev- are included in an expanded group assist in the identification of addition- idence in experimental animals. (who.int)
- Extracts of Aloe vera Linne have been found to exhibit cytotoxicity against human tumour cell lines. (tripod.com)
Mesenchymal tumors2
- [ 1 ] Intestinal leiomyosarcomas are mesenchymal tumors of smooth muscle origin. (medscape.com)
- As reported in a large study on uterine mesenchymal tumors in China, LGESS and HGESS account for 81.2% and 18.8% of all ESSs with definite grade, respectively [ 4 ]. (e-crt.org)
Immunohistochemistry1
- Immunohistochemistry (IHC) is often employed as an adjunct to morphology in uterine sarcoma as morphologic distinction alone is not straightforward and has been shown to be challenging especially with poor differentiation or in cases with equivocal features (Hwang et al. (biomedcentral.com)
Necrosis3
- 4 mitoses/10 high-power fields [HPF]) lesions characterized by cytologic atypia, tumor necrosis, or infiltrative margins. (medscape.com)
- The technique has been increasingly used since 1992, when a 90 % remission rate for STS treated by a combination of chemotherapy and Tumour Necrosis Factor alpha (TNFα) has been demonstrated [ 6 ]. (jcancer.org)
- With high-grade tumors, necrosis often is present. (medscape.com)
Benign1
- Consequently, evaluation of 12q13q15 amplification has been applied clinically as it allows for distinguishing WDLPS/DDLPS from benign adipocytic tumors [ 4 , 5 ]. (biomedcentral.com)
Extraskeletal1
- Extraskeletal myxoid chondrosarcoma (EMC), a soft-tissue sarcoma with unique clinicopathologic features and characteristic chromosomal translocations, is extremely rare in the pediatric population. (cancer-genetics.org)
Diverse tumor types1
- This collection of works by expert clinicians from a variety of disciplines represents an exploration of the current knowledge of the role of neoadjuvant chemotherapy in diverse tumor types. (intechopen.com)
Rearrangement1
- BACKGROUND: The group of undifferentiated round cell sarcomas, according to the World Health Organization Classification, in addition to Ewing's sarcoma (ES), includes round cell sarcoma with rearrangement of the EWSR1 gene with partners not from the ETS gene family, sarcoma with BCOR gene alterations, CIC -rearranged sarcoma. (bvsalud.org)
Suppressor genes2
- This is in contrast with tumor suppressor genes which must BOTH be defective to lead to abnormal cell division. (cancerquest.org)
- Knowledge of alterations in genome structure could also facilitate identification of corresponding oncogenes or tumor suppressor genes associated with the pathogenesis or progression of the disease. (biomedcentral.com)
Cells19
- EPA also inhibited growth of the MAC16 tumor in a dose-dependent manner, and this correlated with suppression of the expression of the 20S proteasome α-subunits in tumor cells, suggesting that this may be the mechanism of tumor growth inhibition. (aacrjournals.org)
- It remains to be determined whether SOX10-positive cells in intraneural synovial sarcoma represent entrapped Schwann cells, synovial sarcoma cells or both. (eurekamag.com)
- While the origin of these tumors is still not definitively known, the two theories with the most support suggest that these tumors arise from a primitive cell derived either from an embryologic tissue called the neural crest, or from resident cells in the body (called mesenchymal stem cells) that have a capability to become one of a variety of tissue types. (sarcomahelp.org)
- Tumors in the Ewing's family of sarcomas are made of primitive cells, which are cells that haven't yet decided what type of cell they are. (sarcomahelp.org)
- The tumors generally are made up of spindle-shaped cells and have a high cellularity. (medscape.com)
- Histopathology demonstrated well-circumscribed tumor (2 × 1 × 1 cm) as spindle-shaped subepithelial cells hyperplasia, in a "whorled" focal arrangement around collagen stroma and made a storiform structure, with monomorphic nuclei and eosinophilic cytoplasm. (thieme-connect.de)
- Poincloux R, Lizarraga F, Chavrier P . Matrix invasion by tumour cells: a focus on MT1-MMP trafficking to invadopodia. (nature.com)
- Endometrial stromal sarcomas (ESSs), originating from endometrial mesenchymal cells, are rare uterine malignancies that account for approximately 0.2% of uterine malignancies [ 1 , 2 ]. (e-crt.org)
- Microscopically, the tumor was composed of fascicles of spindle-shaped cells with pale eosinophilic cytoplasm with round, oval, and focally elongated nuclei and one or two prominent nucleoli. (biomedcentral.com)
- The tumor cells showed strong diffuse cytoplasmic immunopositivity for myoglobin and vimentin and focal staining for desmin. (biomedcentral.com)
- In contrary, tumor cells have evolved immune escape mechanisms whereby overexpression of PD-L1 induces anergy and/or apoptosis of PD-1 positive T cells by interfering with T cell receptor signal transduction. (studylib.net)
- Consequently, it was shown by others that tumor cells also expressed MHC-I and presented short tumor-associated peptides to immune cells [6]. (studylib.net)
- However, tumor cells can evade host's immune surveillance using a number of protective mechanisms, including downregulation of MHC-I molecules, secretion of anti-inflammatory cytokines, in other words, TGF-β and IL-10, secretion of immunosuppressive factors, VEGF, upregulation of PD-L1 and downregulation of co-stimulatory molecules thereby preventing activation of T cells, resulting in cancer invasion. (studylib.net)
- The binding of T cells expressing PD-1 and tumor cells expressing PD-L1 initiates an array of inhibitory signals resulting in reduced function and/or apoptosis of T cells [8,11] providing a mechanism for tumor cell evasion of host's immune surveillance [12-14]. (studylib.net)
- Furthermore, upregulation of PD-L1 by cancer cells results in cancer invasion and correlates with poor prognostic outcomes in breast, gastric, meningioma, non-small-cell lung carcinoma (NSCLC) and soft-tissue sarcoma patients [9,26-29]. (studylib.net)
- The cytotoxicity mechanism consists of the induction of apoptosis, whereas the selectivity against neuroectodermal tumor cells is founded on a specific energy-dependent pathway of drug incorporation. (tripod.com)
- There is good evidence that cancer cells disseminate from the primary site early during tumor development (Hosseini et al. (biomedcentral.com)
- Such cells are described as disseminated tumor cells (DTC) (Sosa et al. (biomedcentral.com)
- 2014 ) or sometimes as circulating tumor cells (CTC) (Kim et al. (biomedcentral.com)
20161
- 70 ). The term sPNET is now obsolete and was removed from the WHO 2016 Classification of CNS tumors, thanks to an increased understanding of the heterogeneity and biology of these tumors and the emergence of a classification based on molecular characteristics. (medlink.com)
Molecular2
- 2008). Molecular characterization of synovial sarcoma in children and adolescents: evidence of akt activation. (nature.com)
- The World Health Organization 2021 Classification (WHO CNS5), based on an integrated taxonomy with a strong emphasis on molecular profiling, established two types of embryonal tumors: medulloblastomas and other CNS embryonal tumors. (medlink.com)
Chemotherapy1
- Radiation therapy does not appear to be beneficial and the efficacy of chemotherapy has not been demonstrated in this type of tumour. (scitechnol.com)
Histologic2
- GISTs, however, have been shown to lack characteristics of smooth muscle tumors on histologic examination. (medscape.com)
- The term "sarcoma" identifies a heterogeneous group of rare tumors comprising over 60 different histologic variants ( 1 ). (frontiersin.org)
Vitro3
- Although histone deacetylase (HDAC) inhibitors are known to suppress synovial sarcoma in vitro and in vivo , the exact mechanism is not clear. (nature.com)
- Soleus muscles from mice bearing a cachexia-inducing tumor (MAC16) showed an increased protein degradation in vitro , as measured by tyrosine release, when compared with muscles from nontumor-bearing animals. (aacrjournals.org)
- Here we report that aloe-emodin (AE), a hydroxyanthraquinone present in Aloe vera leaves, has a specific in vitro and in vivo antineuroectodermal tumor activity. (tripod.com)
Diagnostic7
- Synovial sarcoma and malignant peripheral nerve sheath tumor pose a significant diagnostic challenge given similar histomorphology. (eurekamag.com)
- The goal of the present study was to determine the diagnostic utility of SOX10 to discriminate between synovial sarcoma and malignant peripheral nerve sheath tumor. (eurekamag.com)
- Furthermore, the stain needs to be interpreted with caution in intraneural tumors in order to avoid a potential diagnostic pitfall. (eurekamag.com)
- We aimed to assess the diagnostic utility of Transgelin, Stathmin, BCOR and Cyclin-D1 separately and in-combinations in distinguishing ULMS from ESS, and to evaluate their prognostic value in patients with such sarcoma subtypes. (biomedcentral.com)
- Due to the unique features of the population affected by these entities, rare embryonal tumors deserve specific understanding, comprehensive diagnostic tools, and the development of much-needed novel tailored treatment approaches prioritizing less-toxic therapies to the immature nervous system. (medlink.com)
- BACKGROUND: Undifferentiated small round cell sarcomas (URCSs) represent a diagnostic challenge, and their optimal treatment is unknown. (bvsalud.org)
- Somatic copy number aberrations (CNAs) occur commonly in human cancer and evaluation of their characteristic patterns may be used as a diagnostic tool, especially in soft tissue sarcomas [ 3 ]. (biomedcentral.com)
Soft tissue sarcomas4
- Brachytherapy, interstitial tumor bed irradiation, following conservative surgery has been shown to provide excellent local control and limb preservation in patients with soft tissue sarcomas (STS), whereas little is known about the tolerance of peripheral nerves to brachytherapy. (biomedcentral.com)
- Success in the management of soft tissue sarcomas (STS) is often limited by the extension of lesions to neurovascular structures, because of the difficulty in dissecting the neurovascular bundle from the tumor without compromising the function and local recurrence of residual lesions. (biomedcentral.com)
- Soft tissue sarcomas (STS) are tumours arising from connective tissues, with an incidence of about 5 per 100'000 [ 1 ]. (jcancer.org)
- It accounts for only 0.8 to 1% of all cancers and represents 1 to 1.8% of superficial soft tissue sarcomas. (thieme-connect.de)
Inhibition2
- Treatment of mice bearing the MAC16 tumor with the polyunsaturated fatty acid, eicosapentaenoic acid (EPA), attenuated loss of body weight and significantly suppressed protein catabolism in soleus muscles through an inhibition of an ATP-dependent proteolytic pathway. (aacrjournals.org)
- Thus EPA antagonizes loss of skeletal muscle proteins in cancer cachexia by down-regulation of proteasome expression, and this may also be the mechanism for inhibition of tumor growth. (aacrjournals.org)
Brain5
- Medulloblastoma is the most common embryonal brain tumor, whereas other embryonal tumor types are considered "rare" and typically affect infants and very young children. (medlink.com)
- The common embryonal brain tumor medulloblastoma and the rare atypical rhabdoid teratoid tumor are well-defined entities in terms of their histopathological features, immunophenotype, and genetic profiles, as are other brain tumors occurring in this age range, including choroid plexus tumors and infant gliomas, and they are discussed in separate articles. (medlink.com)
- Although uncommon in children younger than 2 years of age, primary CNS tumors at this age comprise almost 15% of all childhood brain tumors. (medlink.com)
- The primary objective of the UMHS was to determine if pesticides were associated with an increased risk of glioma, the most common type of brain tumor in adults [ 13 ]. (cdc.gov)
- Gliomas were studied to increase the homogeneity of the case group, in contrast with previous studies that have combined different types of brain tumors with likely different etiologies [ 14 ]. (cdc.gov)
Uterine1
- We included 44 patients with uterine sarcoma. (biomedcentral.com)
Ewing's6
- The family and friends of Michael Lio have raised more than $100,000 for Ewing's sarcoma research in his memory. (sarcomahelp.org)
- The family and friends of Nicholas Theodore Strub have raised more than $17,000 for Ewing's sarcoma research in his memory. (sarcomahelp.org)
- Ewing's sarcoma is one of more than 50 kinds of sarcoma. (sarcomahelp.org)
- What is Ewing's Sarcoma Family of Tumors? (sarcomahelp.org)
- Ewing's sarcoma (ES) was first described by James Ewing in 1921 as a 'diffuse endothelioma of bone' (Ewing 1921). (sarcomahelp.org)
- Subsequently, these two tumors have been grouped into a class of cancers entitled Ewing's Sarcoma Family of Tumor (ESFT), all of which demonstrate this translocation. (sarcomahelp.org)
Characteristic2
- The SS18-SSX oncoprotein, characteristic of synovial sarcoma, maintains EGR1 expression at low levels, whereas it is significantly increased after HDAC inhibitor treatment. (nature.com)
- However, over time, the staghorn-branching vascular pattern representative of HPC was found to be present at least focally in 15% of all soft-tissue tumors and was more of a characteristic histopathologic pattern than a specific clinicopathologic entity. (medscape.com)
Histiocytic2
- Histiocytic sarcoma is a tumor derived from histiocytes. (wikipedia.org)
- Whole exome and transcriptome analysis revealed the activation of ERK and Akt signaling pathway in canine histiocytic sarcoma. (go.jp)
World Health Organ1
- The 2020 World Health Organization tumor classification system acknowledges four categories within the endometrial stromal tumors: endometrial stromal nodule, low-grade ESS (LGESS), high-grade ESS (HGESS), and undifferentiated uterus sarcoma (UUS), among which LGESS and HGESS are histologically, genetically and clinically distinct from UUS [ 3 ]. (e-crt.org)
Characterization1
- Characterization of alveolar soft part sarcoma using a large national database[J]. Surgery, 2020, 168(5): 825-830. (med-sci.cn)
Resection7
- It is diagnosed using immunohistochemical technique and the treatment of choice is surgical resection of the tumour in order to prevent recurrences. (scitechnol.com)
- Usually, local resection of the tumour is sufficient. (scitechnol.com)
- However, in some situations, infiltration of the tumour requires more extensive resection of adjacent tissues. (scitechnol.com)
- As far as possible, treatment involves complete resection as the presence of remnants of intraorbital tumour tissue after the operation carries the risk of causing recurrence of the tumour and can even undergo transformation by becoming malignant [ 3 ]. (scitechnol.com)
- The biopsy should be placed in line with the incision for definitive tumor resection to allow en-bloc resection of the biopsy tract. (medscape.com)
- To achieve negative resection margins, the width of the tumor-free margins and infiltrating depth are two essential factors to be considered for complete excision for both WLE and MMS surgical techniques. (thieme-connect.de)
- Systemic manifestations of localized, nonmetastatic EMC have never been described in the pediatric population, yet our patient's anemia and poor weight gain resolved after successful surgical resection of the tumor, suggesting that localized EMC can present with systemic manifestations. (cancer-genetics.org)
Angiosarcoma1
- Angiosarcoma is a rare soft tissue tumour and forms less than 1% of all sarcomas. (ijsurgery.com)
Survival2
- Taken together, our findings indicate that SS18-SSX-mediated attenuation of an EGR1-PTEN network regulates synovial sarcoma cell survival, and that HDAC inhibitor-mediated apoptosis operates at least in part through reactivation of this pathway. (nature.com)
- Deceases for other causes were nearly exclusive of elderly patients at a median of 45.57 months.Surgery is the treatment of choice for sarcomas in both elderly and young patients having similar results in terms of progression-free survival, overall survival, and surgery outcomes. (sagepub.com)
EWSR11
- The tumor also contained a novel t(2;22)(q34;q12) translocation involving the EWSR1 gene, which is consistent with additional reports suggesting that a growing list of translocations can drive formation of, and potential new management strategies for, EMC. (cancer-genetics.org)
20192
- MRI findings of 3 cases with alveolar soft-part sarcoma and literature review[J]. J Pract Med Imaging, 2019, 20(1): 41-43. (med-sci.cn)
- METHODS: URCS patients treated from 1983 to 2019 at 21 worldwide sarcoma reference centres were retrospectively identified. (bvsalud.org)
Pathway3
- The ATP-ubiquitin-dependent proteolytic pathway is considered to play a major role in muscle catabolism in cachexia, and functional proteasome activity, as determined by "chymotrypsin-like" enzyme activity, was significantly elevated in gastrocnemius muscle of mice bearing the MAC16 tumor as weight loss progressed. (aacrjournals.org)
- We have identified a novel pathway that directs Lyn/Src family tyrosine kinase signals to the invadopodia to regulate sarcoma cell invasion via the molecule AFAP-1-like-1 (AFAP1L1), a new member of the AFAP (actin filament-associated protein) family. (nature.com)
- These data define a novel pathway that directs Lyn/Src family tyrosine kinase signals to sarcoma cell invadopodia through specific recruitment of Vav2 and Nck2 to phosphorylated AFAP1L1, to control cell migration and invasion. (nature.com)
Synovial sarcomas4
- The distinction is further complicated by similar immunophenotype and especially by occasional synovial sarcomas that present as intraneural tumors. (eurekamag.com)
- Forty-eight cases of malignant peripheral nerve sheath tumor, all from patients with documented neurofibromatosis, and 97 cases of genetically confirmed synovial sarcoma, including 4 intraneural synovial sarcomas, were immunohistochemically stained for SOX10. (eurekamag.com)
- By contrast, only 7/97 (7%) synovial sarcomas were SOX10-positive. (eurekamag.com)
- Only three synovial sarcomas showed ≥2+ staining but, importantly, two of these were intraneural synovial sarcoma. (eurekamag.com)
Cancer1
- Angiogenesis-promoting gene patterns in alveolar soft part sarcoma[J]. Clin Cancer Res, 2007, 13(24): 7314-7321. (med-sci.cn)
Specificity1
- High sensitivity and specificity of CD99/NKX2.2 co-expression for ES, BCOR/SATB2/TLE1 for sarcoma with BCOR gene alterations, high specificity and low sensitivity of WT1/ETV4 co-expression for CIC-rearranged sarcoma was shown. (bvsalud.org)
Malignancy1
- Synovial sarcoma is a high-grade soft tissue malignancy, for which current cytotoxic chemotherapies provide limited benefit. (nature.com)
Chromosomal1
- Drs. Gabriela Mercado and Frederic Barr of the University of Pennsylvania present an excellent discussion of chromosomal translocations in sarcomas elsewhere on this site. (sarcomahelp.org)
Pathological1
- The median tumor size, defined as the maximum diameter of the tumor at pathological analysis, was 9.4 cm (range, 5.5-13.0 cm). (biomedcentral.com)
Genetically1
- OBJECTIVE: Present a comparative analysis of genetically verified ES, sarcoma with BCOR gene alterations and CIC-rearranged sarcoma. (bvsalud.org)
Classification1
- 8] The 2020 WHO classification of soft-tissue tumors listed SFT as an intermediate (rarely metastasizing) tumor. (medscape.com)
Lung1
- Detection of Human Lung Epithelia Cell Growth Factors Produced by a Lung Carcinoma Cell Line: Use in Culture of Primary Solid Lung Tumors. (epa.gov)
Chromosome1
- In particular, about one third of all sarcomas presents pathognomonic chromosome rearrangements (translocations, deletions, insertions) that result in fusion genes and corresponding expression of fusion transcripts ( 4 ). (frontiersin.org)
Oncology1
- Imaging features of alveolar soft-part sarcoma: a report from Children's Oncology Group Study ARST0332[J]. AJR Am J Roentgenol, 2014, 203(6): 1345-1352. (med-sci.cn)
Spindle cell1
- Identification of AFAP1L1 as a prognostic marker for spindle cell sarcomas. (nature.com)
Heterogeneous1
- on the contrary, heterogeneous structure is typical for sarcoma with alterations of the BCOR gene, CIC-rearranged sarcoma. (bvsalud.org)
Material and Methods1
- MATERIAL AND METHODS: A comparative study of biopsy specimens of bones, soft tissues and internal organs was carried out in 118 patients with ES, 10 with BCOR gene alterations and 8 with CIC-rearranged sarcomas. (bvsalud.org)
Surgical1
- The primary treatment for DFSP is surgical excision, which is wide local excision (WLE) with tumor-free margins, Mohs micrographic surgery (MMS), and partial or total amputation. (thieme-connect.de)