Tumor cell. Medical search. Frequent questions

Surgical staging is the first step in the management of ovarian germ cell cancer . (medscape.com)
Is Tumor a Cancer? (medicinenet.com)
[ 115-117 ] In cancer cell line spike-in experiments, this method was capable of detecting one cancer cell per 5 ml blood. (medscape.com)
Also, cathepsin D or MUC1 secreting cells were successfully detected in breast cancer patients but not in healthy controls. (medscape.com)
[ 115 ] Moreover, CK19 releasing cells were found to be detectable in up to 65 and 70% of CRC and breast cancer patients, respectively, and correlated with presence of metastasis and poor survival in breast cancer. (medscape.com)
These tests also can show how the cancer treatment is working and, after treatment, whether the tumor has come back. (kidshealth.org)
Distinct hallmarks of cancer were examined using in silico analysis, various in vitro cell culture assays, and ex vivo organotypic rat brain slice culture model. (hindawi.com)
Besides, upregulated MCT4 has been linked to altered tumor metabolism as well as to increased growth and survival in breast and pancreatic cancer [ 33 , 34 ]. (hindawi.com)
For this purpose, we designed an MCT4 overexpression and knockdown/inhibition model to explore the functional consequences of MCT4 expression on cancer cell metabolism, survival, proliferation, migration, invasion potential, and angiogenesis as well as on cell cycle profiles and cell death mechanisms. (hindawi.com)
In general, all women with malignant germ cell tumors will have the same staging surgery that is done for epithelial ovarian cancer. (cancer.org)
Most women with germ cell cancer will need to be treated with combination chemo for at least 3 cycles. (cancer.org)
Extracellular ST6GAL1, present in cancer exosomes or the freely soluble recombinant sialyltransferase, compensates for insufficient intrinsic ST6GAL1 by boosting cancer cell proliferation and increasing invasiveness. (nature.com)
It is within the cell-autonomous context that ST6GAL1 involvement in cancer progression has been interpreted. (nature.com)
Aggressive breast cancer is a highly heterogeneous disease caused by a variety of distinct cell-intrinsic genetic alterations in mammary epithelial cells, leading to vastly heterogenic disease manifestation in individual patients and predominantly affecting patient prognosis and treatment options [ 14 ]. (nature.com)
Cancer cell-extrinsic mechanisms, which are poorly understood, are also believed to contribute to disease progression and the heterogeneous genetic mutations with diverse presentations. (nature.com)
The primary aim of cancer immunotherapy is to enhance immune cells to prevent cancer cells from escaping the immune system's control. (medicalnewstoday.com)
In new research published in the journal Cancer Research , researchers explain how the stress response experienced by T cells can reduce their effectiveness at restricting tumor growth. (medicalnewstoday.com)
When a T cell encounters cancer cells, PERK can react to the stressors, such as lack of glucose, an important nutrient for cells. (medicalnewstoday.com)
However, the researchers in the current study said that this natural T cell response to stress would actually harm the effectiveness of cancer immunotherapy when it comes to stopping tumors. (medicalnewstoday.com)
One of the reasons that cancer is so difficult to prevent is the complex interaction between individual cancer cells and the tumor microenvironment. (medicalnewstoday.com)
When T cells are under stress (like when they must fight cancer cells), PERK causes T cells to stop secreting proteins in order to protect and help the T cell survive. (medicalnewstoday.com)
Individuals with MEN1 are at a substantially increased risk of developing neuroendocrine tumors, including cancer of the pancreatic islet cells that secrete insulin. (medindia.net)
Scientists have identified that pancreatic cancer cells growth and spread are fueled by an unusual metabolic pathway that someday might be blocked with targeted drugs to control the deadly cancer. (medindia.net)
In this study conducted in partnership with the Institut Polytechnique de Paris and Inserm, the scientists created a 3D cancer cell culture which replicates tumor structure more effectively than traditional cultures. (pasteur.fr)
They then introduced cytotoxic T cells in proximity to the cancer cells and monitored their behavior by microscopy. (pasteur.fr)
A recent study by cancer researcher Chawnshang Chang, Ph.D. , provides additional proof of a concept he's been investigating for years: that the environment surrounding a prostate tumor plays a major role in metastasis, and new treatments should be designed to target that environment as well as the tumor itself. (rochester.edu)
Published by the International Journal of Oncology , Chang's laboratory found that bone marrow derived stem cells, which are recruited to the site of a growing tumor, are able to convert nearby normal fibroblast cells into cancer cells, resulting in tumor metastasis. (rochester.edu)
Investigators are starting to realize that tumor proliferation and tumor migration are two different things and should be treated as such," said Chang, the George Hoyt Whipple Distinguished Professor of Pathology, Urology, and Radiation Oncology at the University of Rochester and Wilmot Cancer Institute. (rochester.edu)
The latest paper suggests the microenvironment-the neighborhood of cells surrounding the tumor-is where stem cells can be recruited through altered cytokine-AR signals to boost prostate cancer metastasis. (rochester.edu)
Although the primary importance of CTCs is their ability to seed metastatic tumors, their constant presence in the blood have made their detection an attractive alternative to the traditional biopsy for clinical applications such as cancer screening, therapy evaluation and disease prognosis. (uh.edu)
Unambiguously detecting live circulating tumor cells opens the door for many clinical applications, such as convenient and instantaneous monitoring of the effectiveness of clinical cancer treatment and monitoring cancer relapse. (uh.edu)
Note the plasma membrane expression of the lactate transporter in WiDr, FaDu, SiHa, and PC-3 cancer cells. (jci.org)
Scientists from the German Cancer Research Center (DKFZ) and the University Medical Center Mannheim (UMM) successfully tested a new form of cellular immunotherapy against brain tumors in mice for the first time. (dkfz.de)
Lukas Bunse, a scientist at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and a physician at the University Medical Center Mannheim, relies on the comparatively new concept of "T cell receptor transgenic cells" in his current study: To this end, brain tumor patients were first inoculated with an antigenic fragment of the protein NLGN4X (Neuroligin4X). (dkfz.de)
In this way, they succeeded in producing large numbers of T cells with identical specificity, all of which recognize the cancer antigen NLGN4X. (dkfz.de)
In melanoma, the malignant black skin cancer, such T-cell receptor transgenic T cells have already been shown to prolong the lives of some patients. (dkfz.de)
According to the scientist, it is also conceivable to generate T cell receptor transgenic cell therapies against patient-individual cancer antigens. (dkfz.de)
The discovery that the gene-mannose 6-phosphate/insulin-like growthfactor II receptor (M6P/IGF2r)-acts as a tumor-suppressor genein human liver tumors could help researchers develop an earlydiagnostic test for liver cancer as well as new treatments, theresearchers said. (cancernetwork.com)
Because the receptor is involved both in switching on a growthinhibitor and inactivating a growth factor, the researchers hypothesizedthat losing it might well predispose a cell to cancerous growth.Their past studies showing that the protein was abundantly presentin normal liver cells but nearly absent in cancer cells strengthenedtheir suspicion. (cancernetwork.com)
Changes in dietary fatty acids, specifically the polyunsaturated fatty acids of the ω-3 and ω-6 families and some derived eicosanoids from lipoxygenases, cyclooxygenases, and cytochrome P-450, seem to control the activity of transcription factor families involved in cancer cell proliferation or cell death. (springer.com)
In mice, a fatal brainstem tumor was cleared by injecting it with engineered T cells that recognized the cancer and targeted it for destruction. (stanford.edu)
In mice whose brainstems were implanted with human DIPG, engineered immune cells known as chimeric antigen receptor T cells - or CAR-T cells - were able to eliminate tumors, leaving very few residual cancer cells. (stanford.edu)
When the brains of the mice were examined via immunostaining after treatment, the animals had, on average, a few dozen cancer cells left, compared with tens of thousands of cancer cells in animals that received a control treatment. (stanford.edu)
As a cancer immunotherapist, what gets me really excited is when you take an established tumor and you make it disappear," said Crystal Mackall , MD, professor of pediatrics and of medicine and the study's other senior author. (stanford.edu)
In CAR-T therapies now used in humans, some of the patient's own immune cells are removed, engineered to attack a surface antigen on the cancer cells, and returned to the patient's body, where they target the cancer cells for destruction. (stanford.edu)
Scientists have known for decades that GD2 levels on some other forms of cancer are very high, but its discovery on this tumor came as a surprise, Mackall said, adding, "It was hiding in plain sight, and we didn't know. (stanford.edu)
Other CAR-T cells that were tuned to different molecular targets also did not kill the DIPG cancer cells. (stanford.edu)
At that time, the oncology community had little enthusiasm for the use of T-cell therapies to treat cancer. (childrensnational.org)
T-cells seek out and destroy cancer cells or virus-infected cells, protecting the body from infection and malignancy. (childrensnational.org)
DNRII-LSTs were resistant to normally inhibitory concentrations of TGF-β in vitro and retained their ability to kill the cancer cells. (childrensnational.org)
Kong B, Michalski CW, Kleeff J. Tumor initiating cells in pancreatic cancer: A critical view. (wjgnet.com)
Emerging evidence points to the existence of pancreatic cancer stem cells (CSC) as the culprit in the initiation, maintenance, metastasis, and treatment resistance of pancreatic cancer. (wjgnet.com)
K-Ras, transforming growth factor-β (TGF-β)] rather than on presumed cancer stem cell pathways. (wjgnet.com)
A team of researchers led by the University of California San Diego has created a device that measures how 'sticky' cancer cells are, which could improve prognostic evaluation of patient tumors. (news-medical.net)
Their work addresses a longstanding problem in the field of cancer research: it has been difficult to find biological markers to universally identify and select the most aggressive cells in tumors. (news-medical.net)
Cancer cells are placed in the chamber and after they adhere, a fluid is pushed through to detach cells. (news-medical.net)
Comparing this signature to thousands of patients in the Cancer Genome Atlas (TCGA) database, researchers found that patients with tumors high in this 'weakly adherent signature' experienced tumor recurrence occurred earlier and more frequently. (news-medical.net)
If our mouse model shows that these cells indeed reduce cancer-free survival times, it will pave the way for substantial prognostic studies in humans with these types of solid tumors,' said first author Pranjali Beri, a bioengineering Ph.D. student in Engler's lab. (news-medical.net)
Information about pediatric CNS Germ Cell Tumors treatment, clinical trials, and research from Texas Children's Cancer Center. (texaschildrens.org)
Texas Children's Cancer Center's Brain Tumor Program and the Neuro-oncology Team treat patients with Intracranial Germ Cell Tumors. (texaschildrens.org)
HANOVER, N.H. (July 15, 2009) - In a feat of trickery, Dartmouth Medical School immunologists have devised a Trojan horse to help overcome ovarian cancer, unleashing a surprise killer in the surroundings of a hard-to-treat tumor. (scienceblog.com)
We have modulated elements of the tumor microenvironment that are not cancer cells, reversing their role as accomplices in tumor growth to attackers that boost responses against the tumor," said Dr. Jose Conejo-Garcia, assistant professor of microbiology and immunology and of medicine, and a researcher at Dartmouth-Hitchcock's Norris Cotton Cancer Center, who led the research. (scienceblog.com)
The Dartmouth work focuses on dendritic cells-an immune cell particularly abundant in the ovarian cancer environment. (scienceblog.com)
But we found that these dendritic cells that are commonly present in ovarian cancer were preferentially and avidly engulfing the nanoparticles. (scienceblog.com)
Dendritic cells are phagocytes-the soldiers of the immune system that gobble up bacteria and other pathogens, but ovarian cancer has co-opted them for its own use, he continued. (scienceblog.com)
The dendritic cells around ovarian cancer scoop up the nanocomplexes, composed of a polymer and small interfering RNA (siRNA) molecules to silence their immunosuppressive activity. (scienceblog.com)
Samples of human ovarian cancer cells show similar responses to nanoparticle stimulation, the researchers observed, suggesting feasibility in the clinical setting. (scienceblog.com)
This image shows generalised cancer cells forming a tumor (tumour) at upper right (greenish blue cell mass). (rkm.com.au)
A few cancer cells are seen floating away. (rkm.com.au)
These represent the migrating cancer cells (metastatic cells) that can exit the tumour via the new vessels (blood & lymph) that drain the growing tumour and / or invade locally. (rkm.com.au)
Cancer happens when a cell breaks free of normal constraints and starts reproducing out of control. (rkm.com.au)
The genetic material of a cancer cell has multiple problems. (rkm.com.au)
Cancer cells growing in a clump become increasingly starved of nutrients. (rkm.com.au)
Cancer cells can also travel along the lymph vessels. (rkm.com.au)
Cancer cells tend to be more spherical than normal cells and their surfaces are characterised by ripples and various projections. (rkm.com.au)
CAR T-cell therapy is a type of immunotherapy in which T cells are removed from a patient's body and genetically modified so that they can recognize the patient's cancer cells. (aacr.org)
The modified T cells, when reintroduced into the patient's body, multiply and attack cancer cells. (aacr.org)
In a phase I clinical trial , a team of researchers from Memorial Sloan Kettering Cancer Center tested whether mesothelin-directed CAR T cells that they developed would be safe and effective in patients with malignant pleural disease from mesothelioma and lung and breast cancer. (aacr.org)
The CAR T cells the team developed, called IcasM28z, target the cell-surface protein, mesothelin, which is expressed on the majority of cancer cells. (aacr.org)
This article in Cancer Discovery reviews the types of solid tumors that express mesothelin, and the potential of mesothelin-directed CAR T-cell therapy to treat such malignancies. (aacr.org)
Using an interventional radiology procedure, the investigators injected IcasM28z CAR T cells directly into the pleural cavity in 21 patients with malignant pleural disease (19 with malignant pleural mesothelioma, one with metastatic lung cancer, and one with metastatic breast cancer). (aacr.org)
Children's Cancer Hospital offers the most up-to-date and advanced chemotherapy options for childhood germ cell tumors. (mdanderson.org)
Radiation therapy (also called radiotherapy) uses high-energy beams to destroy cancer cells. (mdanderson.org)
New radiation therapy techniques and remarkable skill allow Children's Cancer Hospital doctors to target tumors more precisely, delivering the maximum amount of radiation with the least damage to healthy cells. (mdanderson.org)
Children's Cancer Hospital is committed to providing the most advanced treatments for childhood germ cell tumors with the least impact on your child's body, today and in the future. (mdanderson.org)
Children's Cancer Hospital offers a range of clinical trials for childhood germ cell tumors. (mdanderson.org)
Childhood germ cell tumors are treated in our Children's Cancer Hospital and our Proton Therapy Center. (mdanderson.org)
At Dana-Farber/Boston Children's Cancer and Blood Disorders Center, your child will receive care at one of the largest and most experienced pediatric brain tumor treatment programs in the world. (dana-farber.org)
Loss of a genome-organization factor gives a subset of cancer cells the ability to self-renew. (cancer.gov)
The molecular makeup and biological properties of cancer cells can vary significantly, even within the same tumor. (cancer.gov)
Using sensitive single-cell analysis methods, including imaging, Scaffidi and her colleagues measured H1.0 in tumor samples from six different types of cancer. (cancer.gov)
What's more, glioblastoma and breast cancer samples that had the highest proportion of cells with low levels of H1.0 tended to be aggressive tumors. (cancer.gov)
Various extracellular signals can influence how much H1.0 a cell produces, and the researchers speculated that interac-tions with the tumor microenvironment could cause some cancer cells to stop producing this critical protein. (cancer.gov)
Supporting this idea, Scaffidi and colleagues also noted that histone H1.0 is consistently low in cancer stem cells, which have an unlimited potential to divide. (cancer.gov)
Dr. Quinones-Hinojosa's lab is studying how the NKCC1 protein maneuvers the cell during migration and using findings to develop new molecular targets for targeted cancer therapy. (mayo.edu)
Dr. Quinones-Hinojosa's lab is studying ways to engineer human fat cells to turn them into cancer-fighting Trojan horses and evaluating a gel to locally administer to patients during brain cancer surgery. (mayo.edu)
The Brain Tumor Stem Cell Research Lab at Mayo Clinic engineers human mesenchymal stem cells with nanotechnology to serve as Trojan horses for the treatment of cancer. (mayo.edu)
Dr. Quinones-Hinojosa's lab is evaluating the efficacy of a gel for administering human fat-derived mesenchymal stem cells within the brain cancer resection cavity during surgery. (mayo.edu)
The lab is creating models to better understand cancer migration and progression, to study invasive cell populations, and to uncover novel therapeutic targets to impact tumor progression. (mayo.edu)
The removal of cells or tissues so they can be viewed under a microscope by a pathologist to check for signs of cancer. (vicc.org)
Therefore, they concluded that CD5L is a TAM marker induced by factors secreted by cancer cells. (managedhealthcareexecutive.com)
Administered in a mouse model of lung cancer, the antibody reduced tumor growth, reprogrammed TAMs and shifted the tumor microenvironment to be "less tumor permissive. (managedhealthcareexecutive.com)
Higher GM-CSF serum levels, they point out, are considered a marker of adverse clinical outcome, especially in patients with non-small cell lung cancer. (managedhealthcareexecutive.com)
The results "open the door to a new line of treatment for lung cancer patients," Sarrias said in an interview, "with the potential to be applied to other solid tumors. (managedhealthcareexecutive.com)
Germ cell cancer is a rare tumor that affects children, teens, and adults. (curesearch.org)
Malignant germ cell tumors include several types of cancer, such as immature teratoma, yolk sac tumor, embryonal carcinoma, and choriocarcinoma. (curesearch.org)
Depending on where the tumor originates, it could present symptoms associated with other, less-serious conditions, causing doctors to overlook germ cell cancer as a cause. (medicalmalpracticehelp.com)
They found that the defect is highly sensitive to an existing FDA-approved drug used to treat ovarian cancer - a discovery that challenges current practice for treatment of brain tumors and other cancers with the same genetic defect, said the scientists. (earthscape.org)
CAR T-cell immunotherapy is an experimental targeted cancer treatment that engineers changes in some cells of your immune system to fight disease. (seattlechildrens.org)
A study analyzing brain tumor genomics on a single-cell level has found evidence that cancer stem cells fuel the growth of oligodendrogliomas, a slow-growing but incurable form of brain cancer. (technologynetworks.com)
In their paper receiving advance online publication in Nature, a team led by investigators at Massachusetts General Hospital (MGH) and the Broad Institute of MIT and Harvard identifies for the first time cancer stem cells and their differentiated progeny in human brain tumor samples. (technologynetworks.com)
Our work strongly supports that cancer stem cells are the main source of growth in these tumors and, as such, should be considered promising targets for treatment," says Mario Suvà, MD, PhD, of the MGH Department of Pathology, co-senior author of the Nature paper. (technologynetworks.com)
It has become clear that cancer stem cells - cells within tumors that exhibit stem cell characteristics and can differentiate into other specialized types of cancer cells - have a role in the progression and treatment resistance of several types of tumors, most prominently blood system tumors like leukemia. (technologynetworks.com)
Several studies have supported a role for cancer stem cells in the aggressive brain tumors called glioblastoma, but those studies involved inducing human tumors to grow in mice, and as such their relevance to cancer in humans has been questioned. (technologynetworks.com)
Their analysis of more than 4,000 individual tumor cells, the largest effort to date in brain tumors, finds three developmental categories of cancer cells - one resembling neural stem cells and two characterized by sets of genes indicting paths towards differentiation. (technologynetworks.com)
The authors then observed that only a subset of cancer stem cells in each patient was showing signs of proliferation, while all other cancer cells were not. (technologynetworks.com)
Our aims are to identify and understand mechanisms regulating breast cancer cell death and how inflammatory signaling can be induced and influence breast cancer progression. (lu.se)
We have discovered that Smac mimetics can induce long-term changes in the breast cancer cell phenotype which includes inflammatory signaling. (lu.se)
The "stem cell theory of cancer" states that a subpopulation of cells with stem cell-like properties plays a central role in the formation, sustainment, spread, and drug resistant characteristics of malignant tumors. (medscape.com)
These findings provide supporting evidence that enrichment for proteins involved in pluripotency is not restricted solely to malignant tumors as is suggested by the "stem cell theory of cancer", but additionally extends to common benign vascular tumors such as hemangiomas. (medscape.com)
Malignant melanoma is the most aggressive type of skin cancer, which initiates in the pigment-producing cells called melanocytes. (lu.se)
Primary small cell neuroendocrine carcinoma of the urinary tract is a very rare cancer , accounting for fewer than 0.5% of urinary tract tumors . (bvsalud.org)
Because of the estimated large volume, many cancer registries do not register basal cell skin cancer except for selected sites, such as skin of the external genital organs (for example, vulva, penis, scrotum). (cdc.gov)
An early cancer that is present only in the layer of cells in which it began. (cdc.gov)
Classification of childhood cancer based on tumor histology. (cdc.gov)
A classification system used by tumor or cancer registries to code the site and the histology of the cancer, usually from a pathology report. (cdc.gov)
CD44 isoforms are heterogeneously expressed in breast cancer and correlate with tumor subtypes and cancer stem cell markers. (lu.se)
The CD44 cell adhesion molecule is aberrantly expressed in many breast tumors and has been implicated in the metastatic process as well as in the putative cancer stem cell (CSC) compartment. (lu.se)
Breast cancer cell lines showed a heterogeneous expression pattern of the CD44 isoforms, which shifted considerably when cells were grown as mammospheres. (lu.se)
MSLN overexpression was found in human lung tumors, lung cancer cell lines, and BSW cells. (cdc.gov)
Cancerous tumors may start in the bone (primary cancer) or start in other. (msdmanuals.com)

In the metabolic symbiosis model, these cells have been proposed to overexpress MCT4 to release high amounts of lactate produced during anaerobic glycolysis into the tumor microenvironment. (hindawi.com)
Challenges include finding the right target to direct the T cells, the ability to expand in an often-immunosuppressive tumor microenvironment, yielding an effective antitumor response, and avoiding adverse side effects. (aacr.org)
Researchers in Spain explore strategies for making tumor microenvironment less "tumor permissive. (managedhealthcareexecutive.com)
Extremely adaptable, they shift their function according to the microenvironment: They can be both pro- and anti-tumor. (managedhealthcareexecutive.com)

Is GCT (Giant Cell Tumor) Cancerous? (medicinenet.com)
However, there is a small risk of GCTs transforming into cancerous tumors. (medicinenet.com)
In some cases, GCTs may recur after treatment, and there is a small risk of GCTs transforming into cancerous tumors. (medicinenet.com)
Women with benign (non-cancerous) germ cell tumors such as mature teratomas (dermoid cysts) are cured by removing the part of the ovary that has the tumor (ovarian cystectomy) or by removing the entire ovary. (cancer.org)
Although giant cell tumors are not cancerous, they are aggressive and can destroy the surrounding bone. (orthoinfo.org)
less than 5% of these tumors are malignant (cancerous). (knowcancer.com)
The vessels can also carry away cancerous cells allowing them to establish new (metastatic) tumors (tumours). (rkm.com.au)
Bone tumors may be cancerous (malignant) or noncancerous (benign). (msdmanuals.com)

As with epithelial ovarian cancers, it is a good idea to consult with a gynecologic oncologist for treating malignant germ cell tumors, especially because these are so uncommon. (cancer.org)
About 2-3% of all ovarian cancers are germ cell tumors. (cancer.org)
Ovarian seromucinous borderline tumors (SMBTs) are rare. (hindawi.com)
Here, we report an unusual combination of bilateral ovarian SMBT and clear cell carcinoma associated with polypoid endometriosis of the colon, in a 62-year-old woman. (hindawi.com)
To the best of our knowledge, this is the first case of this unusual combination of ovarian seromucinous tumor and clear cell carcinoma to be reported in the English literature. (hindawi.com)
Here, we describe the first case, to our knowledge, of an unusual combination of ovarian SMBT and clear cell carcinoma. (hindawi.com)
We suggest that these ovarian tumors and colonic lesions were also associated with separate endometriotic foci. (hindawi.com)
An abdominal computed tomography scan revealed bilateral ovarian tumors and uterine leiomyoma. (hindawi.com)
They represent less than 0.2% of all ovarian tumors . (knowcancer.com)
Ovarian tumors are diagnosed by a physician during a pelvic exam or other physical examination. (knowcancer.com)
Using nanoparticles-ultra small bits- the team has reprogrammed a protective cell that ovarian cancers have corrupted to feed their growth, turning the cells back from tumor friend to foe. (scienceblog.com)
The study, in mice with established ovarian tumors, involves a polymer now in clinical trials for other tumors. (scienceblog.com)
Most germ cell tumors appear in the ovaries ( ovarian tumors ) or testes ( testicular tumors ), but they can also get "trapped" in the brain during the fetal period. (dana-farber.org)
Ovarian and abdominal tumors often present with symptoms like abdominal pain or constipation. (curesearch.org)
Mesothelin (MSLN) is overexpressed in many human tumors, including mesotheliomas and pancreatic and ovarian carcinomas. (cdc.gov)

Teratomas are the most common type of germ cell tumor to develop in extragonadal (not in the ovary or testes) areas. (kidshealth.org)
Doctors usually treat teratomas with surgery because chemotherapy doesn't work in a benign tumor. (kidshealth.org)
There are several sub-types of non-germinomatous germ cell tumors, including teratomas, choriocarcinomas, endodermal sinus tumors (yolk sac tumors), embryonal carcinomas, and mixed tumors. (dana-farber.org)
Benign extragonadal germ cell tumors are called benign teratomas . (vicc.org)
Benign germ cell tumors include certain kinds of teratomas, a type of tumor that may contain several different types of tissue. (curesearch.org)

Protein markers commonly used for circulating tumor cells investigations. (medscape.com)
The Center for Nuclear Receptors and Cell Signaling at the University of Houston has developed a new way to detect very rare and highly heterogeneous circulating tumor cells with high specificity and sensitivity. (uh.edu)
Circulating tumor cells, which are detached from primary tumors to enter the bloodstream, are particularly hard to detect. (uh.edu)
Dr. Shaun Zhang, M.D. Anderson Professor of biology and biochemistry and director of the Center for Nuclear Receptors and Cell Signaling, invented the UniPro which finds rare circulating tumor cells. (uh.edu)
Engineers at the University of Michigan have developed a high speed microfluidic chip that can separate circulating tumor cells (CTCs) from whole blood and analyze them. (medgadget.com)
Circulating tumor cells offer the possibility of "liquid biopsies" that only require a simple blood draw to screen for cancers. (medgadget.com)
For some time, researchers have known that circulating tumor cells exist in the blood of patients with both metastatic and localized solid organ malignancies. (urotoday.com)

What's more, treating a mouse model of human MEN1 syndrome with a Hedgehog pathway inhibitor called Erivedge (FDA-approved in 2012 for metastatic or locally advanced basal cell carcinoma) reduced proliferation of tumor cells and blood insulin levels. (medindia.net)
This study may provide a much-needed physical marker that identifies highly metastatic cells within a heterogeneous tumor cell population. (news-medical.net)
2020) Cell adhesiveness serves as a biophysical marker for metastatic potential. (news-medical.net)

Often, these tumors form in the ovaries or testes. (kidshealth.org)
These malignant tumors most often develop in the ovaries, testes, or tailbone. (kidshealth.org)
Clear cell tumors were also found in both ovaries. (hindawi.com)
Sertoli-Lydig cell tumors (SLCTs), also known as androblastoma or arrhenoblastoma , are a type of sex cord-stromal tumor that originates in the ovaries. (knowcancer.com)
When cells that are meant to form sperm in the testicles or eggs in the ovaries travel to other parts of the body, they may grow into extragonadal germ cell tumors . (vicc.org)
Extragonadal germ cell tumors form in parts of the body other than the gonads (testicles or ovaries). (vicc.org)
Germ cell tumors most commonly appear in the testes for boys and the ovaries for girls. (curesearch.org)

As Leydig cell tumors are rare, these treatments have not been studied as much as treatments for other, more common testicular cancers. (medlineplus.gov)
However, in view of the excellent chemosensitivity of germ cell cancers, clinical judgment can be used if surgical management would significantly increase postoperative morbidity. (medscape.com)
Most types and stages of germ cell cancers of the ovary are treated the same way, with surgery and chemotherapy (chemo). (cancer.org)
Germ cell cancers can raise blood levels of the tumor markers human chorionic gonadotropin (HCG), alpha-fetoprotein (AFP), and/or lactate dehydrogenase (LDH). (cancer.org)
The sialyltransferase ST6GAL1 that adds α2-6 linked sialic acids to N-glycans of cell surface and secreted glycoproteins is prominently associated with many human cancers. (nature.com)
The researchers said they found that T cells that are subjected to the environment of solid cancers undergo a stress response that limits their abilities, hindering their capability to eliminate the tumors. (medicalnewstoday.com)
similar anti-GD2 CAR-T cells are now being tested in clinical trials in a few other cancers. (stanford.edu)
The U.S. Food and Drug Administration has approved two CAR T-cell therapies for blood cancers so far: tisagenlecleucel (Kymriah) for treating certain patients with acute lymphoblastic leukemia or non-Hodgkin lymphoma (NHL), and axicabtagene ciloleucel (Yescarta) for treating certain adults with NHL. (aacr.org)
Given the success of CAR T-cell therapies for blood cancers, the most anticipated next step in the field is the development of this type of immunotherapy for solid tumors. (aacr.org)
Dr. Quinones-Hinojosa's lab has research platforms on novel therapeutics for glioblastoma, cell migration and invasion, cellular therapy, and models of brain and spine cancers, and maintains a human tissue bank. (mayo.edu)
More than 900 children and adolescents are diagnosed with germ cell tumors in the U.S. each year, comprising about 5% of all childhood cancers . (curesearch.org)
Are there CAR T-cell clinical trials for other childhood cancers? (seattlechildrens.org)

As MCT1 was found to be expressed by an array of primary human tumors, we suggest that MCT1 inhibition has clinical antitumor potential. (jci.org)
To more accurately reflect the mechanisms driving oligodendrogliomas, the researchers used RNA sequencing to study directly, on a single-cell level, gene expression in samples from six early-stage human tumors. (technologynetworks.com)

Our results further indicate that MCT4 promotes proliferation and survival by altered cell cycle regulation and cell death mechanisms. (hindawi.com)
Our data indicate that extracellular ST6GAL1 from remote sources can compensate for cellular ST6GAL1-mediated aggressive tumor cell proliferation and invasive behavior and has great clinical potential for extracellular ST6GAL1 as these molecules are in the extracellular space should be easily accessible targets. (nature.com)
Menin mutations lead to increased Hedgehog signaling and cell proliferation. (medindia.net)
The GAS1 protein promotes Hedgehog signaling, and thus by inhibiting Gas1 expression, menin and PRMT5 effectively dial down the pathway's tendency towards cell proliferation. (medindia.net)
The tumors showed glandular proliferation or small nests with invasive growth (Figure 2(d) ). (hindawi.com)
In particular, B-cell activating factor belonging to the TNF family receptor (BAFF-R), B-cell maturation antigen (BCMA), and transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) play critical roles in promoting B-cell survival at distinct stages of development by engaging a proliferation-inducing ligand (APRIL) and/or BAFF. (nih.gov)
Dysregulated signaling by TNFRSF members can promote B-cell survival and proliferation, causing autoimmunity and neoplasia. (nih.gov)
We found that BSW shMSLN cells had decreased cyclin E, and their proliferation rate was reverted to nearly that of untransformed cells. (cdc.gov)
Cell cycle analysis showed that the BSW shMSLN cells had an increased G2 population and a decreased S phase population, which is consistent with the decreased rate of proliferation. (cdc.gov)

A giant cell tumor of bone is a type of benign (noncancerous) tumor that has a wide range of behaviors. (orthoinfo.org)
Treatment for a giant cell tumor almost always involves surgery to remove the tumor and prevent damage to the bone near the affected joint. (orthoinfo.org)
The diagnosis of giant cell tumor of bone is made when a large number of giant cells are seen among a background of other abnormal cells. (orthoinfo.org)
Illustration shows a giant cell tumor at the lower end of the thighbone. (orthoinfo.org)
In rare cases, a patient can have multiple giant cell tumors in different bones, a condition called multi-centric giant cell tumor of bone. (orthoinfo.org)
In rare cases, a giant cell tumor may spread, or metastasize , to the lungs. (orthoinfo.org)
This is different than an isolated, single giant cell tumor of bone. (orthoinfo.org)
The most common symptom of a giant cell tumor is pain in the area of the tumor. (orthoinfo.org)
Your doctor will perform a thorough physical examination and use X-rays and other tests to diagnose a giant cell tumor. (orthoinfo.org)
On X-ray, a giant cell tumor appears as a destructive (lytic) lesion next to a joint. (orthoinfo.org)
X-rays from the front ( left ) and side ( right ) show a giant cell tumor in the lower end of the thighbone. (orthoinfo.org)
Reproduced from Lewis VO, Aboulafia AJ: Giant cell tumor of bone. (orthoinfo.org)
X-ray shows a giant cell tumor in the lower end of the radius bone in the wrist. (orthoinfo.org)
Tenosynovial giant cell tumor (also known as pigmented villonodular synovitis [PVNS]) causes the lining of the joint to become swollen and grow. (msdmanuals.com)
Tenosynovial giant cell tumor usually affects one joint. (msdmanuals.com)

Previous studies have shown that T cells without PERK were better at controlling tumor growth when transfused into tumor-bearing hosts. (medicalnewstoday.com)

STRIvE-01 is a phase 1 trial testing CAR T-cell therapy in children, teens and young adults with relapsed or refractory solid tumors that express the protein EGFR or B7H3. (seattlechildrens.org)

Interestingly, Chang said, his laboratory also discovered that although androgen deprivation therapy shrinks tumors, it also might inadvertently promote cell metastasis due to altered cell signaling in the region of the tumor. (rochester.edu)
These same cells cause metastasis, but their presence opens the possibility for blood-based diagnostics that can identify the presence of an existing tumor within the body. (medgadget.com)
In the future, the team hopes that clinicians will use this microfluidic device to examine tumor biopsies to estimate the likelihood of metastasis and adjust treatment at earlier disease stages. (news-medical.net)
Therefore, it is of importance to identify the molecular mechansims that drive metastasis of melanoma cells. (lu.se)

Efforts to link CD44 to CSCs and tumor progression should consider the expression of various CD44 isoforms. (lu.se)

Children with benign germ cell tumors will have surgery to remove the tumor. (kidshealth.org)

Researchers say T cells used in immunotherapy may be hindered by stress responses induced when encountering solid tumors. (medicalnewstoday.com)
Now, immunotherapy experts suggest that one reason immunotherapy may not always be effective could be the stress response encountered by T cells when they enter solid tumors. (medicalnewstoday.com)
For immunotherapy to be effective, T cells must secrete cytokines, such as cytotoxic cytokines to kill tumor cells. (medicalnewstoday.com)
Fig. 4: A lower level of CAR-mediated TROG-antigen expression was associated with improved clinical response to CAR-NK cell-based immunotherapy. (nature.com)
Read more about how T-cell immunotherapy for CNS tumors works . (seattlechildrens.org)

The study , which was published online April 16 in Nature Medicine, represents the first time a severe human brainstem tumor, diffuse intrinsic pontine glioma, has been eradicated in mice. (stanford.edu)
CNS tumors are brain and spinal cord tumors, such as atypical teratoid/rhabdoid tumor (ATRT), diffuse intrinsic pontine glioma (DIPG) and diffuse midline glioma (DMG). (seattlechildrens.org)

Yolk sac tumor (also called endodermal sinus tumor). (kidshealth.org)

Early on, a child with a benign or malignant germ cell tumor might have few symptoms or none at all. (kidshealth.org)
Malignant germ cell tumors can spread to other parts of the body before they are diagnosed. (mdanderson.org)

Tumor markers, including Ca-125, alpha-fetoprotein, lactate dehydrogenase (LDH), and beta-human chorionic gonadotropin (beta-hCG) may be evaluated before surgery. (medscape.com)
In the event of recurrence, confirmed residual disease, or elevated tumor markers after first-line chemotherapy, recommended treatment consists of paclitaxel (Taxol)-ifosfamide-cisplatin (TIP) or high-dose chemotherapy. (medscape.com)
Alpha-fetoprotein (AFP) and beta-human chorionic gonadotropin (β-HCG) tests look for higher than normal levels of these proteins (called tumor markers ). (kidshealth.org)
Current methods of detecting CTCs mainly rely on immunological detection of protein markers on the tumor cells. (uh.edu)
These are called tumor markers . (vicc.org)
Blood levels of the tumor markers help determine if the tumor is a seminoma or nonseminoma. (vicc.org)

The researchers proposed that the PERK response may inhibit protein secretion by T cells, making them less effective in fighting tumors. (medicalnewstoday.com)
Now, researchers at the Perelman School of Medicine at the University of Pennsylvania have found that pathway, which may lead to a new treatment for patients with MEN1 and sporadic endocrine tumors. (medindia.net)
However, some mice experienced dangerous levels of brain swelling, a side effect of the immune response triggered by the engineered cells, the researchers said, adding that extreme caution will be needed to introduce the approach in human clinical trials. (stanford.edu)
Researchers found that weakly adherent cells migrated and invaded other tissues more than the strongly adherent cells from the same tumor. (news-medical.net)
Researchers found that if a gene called Apc is lost or damaged, then its normal function of controlling the adult stem cell population breaks down and ultimately leads to a tumor. (genengnews.com)
Boston, MA (UroToday.com) As one of the most influential researchers and thought-leaders in the development of circulating tumor cell (CTC) technology, Dr. Mehmet Toner presented the AUA audience with an incredible review of the current state of the field. (urotoday.com)
For the first time, researchers were able to find enough viable tumor cells, in an efficient manner, to make a meaningful clinical impact. (urotoday.com)
Developing CAR T-cell therapies for solid tumors, however, has been challenging, and researchers in the field have had several failed attempts. (aacr.org)
The researchers, including the study's senior author Michel Sadelain, MD, PhD , therefore incorporated an Icaspase-9 (inducible caspase-9) safety "suicide" switch that can be activated in a patient's body in case of an unexpected toxicity, to eliminate all CAR T cells. (aacr.org)
Researchers don't know the cause of germ cell tumors. (dana-farber.org)
The researchers found that they could drive tumor cells to differentiate and lose their proliferative poten-tial by restoring H1.0 production. (cancer.gov)
Researchers in the Brain Tumor Stem Cell Research Lab are investigating the oncostatic effects of melatonin on glioblastoma to improve treatment and provide better quality of life for patients. (mayo.edu)
Led by Maria Rosa Sarrias , Ph.D., the researchers had found in an earlier study that CD5L, a glycoprotein, drove cells toward a polarization similar to that induced by IL10, and that IL10-activated macrophages in vitro overexpressed CD5L. (managedhealthcareexecutive.com)
The RImAb-associated increase in neutrophils was also in line with higher levels of tumor GM-CSF, a chemoattractant for neutrophils that may have antitumor activity.In contrast, the researchers observed diminished levels of GM-CSF in the serum of RImAb-treated animals. (managedhealthcareexecutive.com)
The researchers suggest that the poor results may be because the treatment is appropriate only for patients with SPINK1-positive tumors. (sciencedaily.com)
There was no substantial change in brain tumor incidence among adults 5 to 10 years after cell phone usage sharply increased, revealed by researchers. (healthnewstrack.com)
Researchers identified 60,000 patients who were diagnosed with these types of brain tumors between 1974 and 2003. (healthnewstrack.com)
The researchers found that incidence rates over this 30 year-period were stable, decreased, or continued a gradual increase that started before the introduction of cell phones. (healthnewstrack.com)
In a new study, Yale researchers identified a novel genetic defect that prevents brain tumor cells from repairing damaged DNA. (earthscape.org)
Seattle Children's doctors and researchers are leaders in developing investigational chimeric antigen receptor (CAR) T-cell immunotherapies for children, teenagers and young adults with central nervous system (CNS) tumors , including DIPG. (seattlechildrens.org)

This process enables tumor cells, including those within the core of the heterogeneous tumor mass to survive, despite being at a distance from blood vessels that supply their metabolic needs [ 16 , 17 ]. (hindawi.com)

Brain tumor-bearing mice treated with transgenic NLGN4X-specific human T cells had a greater than 40 percent response to treatment. (dkfz.de)
Crystal Mackall says she is encouraged that the work in mice showed that engineered immune cells called CAR-T cells were able to eradicate the tumors in mice. (stanford.edu)
Next, the team tested the GD2 CAR-T cells in mice whose brainstem was implanted with human DIPG tumors, an experimental system that Monje's lab pioneered. (stanford.edu)
Here we show that a 'blocking' antibody to SPINK1 could slow the growth of prostate tumors in mice that were positive for the SPINK protein," says study author Arul Chinnaiyan, M.D., Ph.D., director of the Michigan Center for Translational Pathology and a Howard Hughes Medical Institute Investigator. (sciencedaily.com)

After the incubation period, the cells are removed and secreted protein 'spots' are detected by immunological techniques and counted, where each spot corresponds to 1 live CTC (Figure 4). (medscape.com)
After the incubation period, cells are washed out and the released protein spots are detected by the incubation with a fluorochrome-conjugated antibody and counted. (medscape.com)
The research focuses on a protein called PKR ER-like kinase (PERK), which is important for sensing stress in all types of cells, including T cells. (medicalnewstoday.com)
One of the mechanisms of action through which T cells can restore function in a low glucose environment is an enzyme (PERK = PKR ER-like kinase), which can modify a protein (eif2) to overcome inhibition of T cell metabolism. (medicalnewstoday.com)
The protein receptor produced by M6P/IGF2r is an attractive targetbecause it is present on the cell surface and in the plasma, Jirtlesaid, making it readily accessible for use in both liver tumortherapy and diagnosis. (cancernetwork.com)
When working properly, the M6P/IGF2r receptor protein has at leastthree distinct regulatory roles within a cell, said Jirtle. (cancernetwork.com)
Now, CCR scientists have uncovered a key determinant of these growth-sus-taining cells: loss of a DNA-packaging protein called linker histone H1.0. (cancer.gov)
How then does a chromatin protein affect the tumor poten-tial of individual cells? (cancer.gov)
In the BrainChild-03 trial, a patient's own T cells are reprogrammed to recognize and target the protein B7-H3, which is expressed on many pediatric CNS tumors but not healthy brain tissue. (seattlechildrens.org)
Granular cell tumor: immunohistochemical assessment of inhibin-alpha, protein gene product 9.5, S100 protein, CD68, and Ki-67 proliferative index with clinical correlation. (medscape.com)
Semi-quantitative evaluation of our immunohistochemical staining revealed that protein expression of Oct4, Nanog, Myc, and Sox2, but not Klf4, was significantly increased in benign, borderline, and malignant vascular tumors relative to non-diseased vascular tissue controls. (medscape.com)
Moreover, we show that the RNA-binding protein human antigen R (HuR) drives melanoma cell motility, and targeting HuR with a specific HuR inhibitor, MS-444, significantly reduces melanoma cell migration. (lu.se)
Prolia works by blocking a protein called RANK (receptor activator of nuclear factor kappa beta) and helps prevent bone cells called osteoclasts from breaking down bone in the body. (medlineplus.gov)

The signs and symptoms of GCTs may vary depending on the location and size of the tumor. (medicinenet.com)
These tests help doctors see the size of the tumor and where it is. (kidshealth.org)

Giant cell tumors (GCTs) are benign or noncancerous. (medicinenet.com)
Giant cell tumors (GCTs) are benign (noncancerous) tumors that most commonly occur in the bones of the arms and legs. (medicinenet.com)
While giant cell tumors are typically benign (noncancerous), they can grow quickly and destroy bone close to a joint. (orthoinfo.org)
These tumors are noncancerous (benign) but can cause severe damage to the joint. (msdmanuals.com)

This phenomenon could be offset by a dual-CAR system incorporating both an activating CAR against the cognate tumor antigen and an NK self-recognizing inhibitory CAR that transferred a 'don't kill me' signal to NK cells upon engagement with their TROG + siblings. (nature.com)
This system prevented trogocytic antigen-mediated fratricide, while sparing activating CAR signaling against the tumor antigen, and resulted in enhanced CAR-NK cell activity. (nature.com)
Fig. 2: Impact of antigen-induced self-engagement on CAR-NK effector cell phenotype and function. (nature.com)
Fig. 3: Impact of TROG-antigen acquisition on CAR-NK cell phenotype and function in vivo. (nature.com)
CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape. (nature.com)
Bunse's team then isolated from the blood of the vaccinated individuals those T cells that had been activated by NLGN4X and consequently carried a T cell receptor that specifically "recognizes" this glioblastoma-associated antigen. (dkfz.de)
Much more advanced in clinical development than T-cell receptor transgenic cells are cellular therapies using so-called CAR-T (chimeric antigen receptor) cells, which have already been approved for the treatment of various leukemias and lymphomas. (dkfz.de)
A pair of studies presented at the AACR Annual Meeting 2019 demonstrated encouraging clinical outcomes with two different chimeric antigen receptor (CAR) T-cell therapies for patients with advanced solid tumors. (aacr.org)

This is an article of high relevance for T cell biology and T cell therapy in general," she said. (medicalnewstoday.com)
CTCs, like the tumors they are originally detached from, lack unique and well-defined universal biomarkers highlighting the challenges of detection specificity," reports Dr. Shaun Zhang, M.D. Anderson Professor of biology and biochemistry and director of the Center for Nuclear Receptors and Cell Signaling. (uh.edu)
Zhang's research team includes Xinping Fu and Lihua Tao, both from the Department of Biology and Biochemistry and Center for Nuclear Receptor and Cell Signaling at UH. (uh.edu)
BMC Cell Biology, 9 , 45. (springer.com)
Visit the Tumor Cell Biology groups research portal via this link. (lu.se)

A and B ) MCT1 was detected by western blot ( A ) and confocal microscopy ( B ) in human tumor cell lines and control tissues. (jci.org)
Treatment for germ cell tumors depends upon the child's age and overall health, the types of tissues in the tumor, the tumor's location, the child's tolerance for specific types of procedures and the overall prognosis. (mdanderson.org)
A procedure in which a sample of blood is examined to measure the amounts of certain substances released into the blood by organs, tissues , or tumor cells in the body. (vicc.org)
With the exception of Myc (which was only present in a subset of benign, borderline, and malignant tumors), Oct4, Nanog, Sox2, and Klf4 were detectable at variable levels across both normal and diseased tissues. (medscape.com)
The study of tissues and cells under a microscope. (cdc.gov)
The immune system is comprised of highly specialized q The findings and conclusions in this report are those of the authors and cells, tissues, and organs that give the human body the do not necessarily represent the views of the Agency for Toxic Substances and Disease Registry. (cdc.gov)

In vivo, BSW shMSLN cells formed smaller primary tumors and less metastases. (cdc.gov)

Chemotherapy may be used to treat this tumor. (medlineplus.gov)
What's more, they infused patients with the tumor-directed T-cells without requiring "pretreatment" chemotherapy. (childrensnational.org)
Malignant tumors may require further chemotherapy or radiation therapy following the operation. (knowcancer.com)

What Are the Signs & Symptoms of Germ Cell Tumors? (kidshealth.org)
A child with an extracranial, extragonadal germ cell tumor may experience the following symptoms and signs. (cancer.net)
Sometimes, children with a germ cell tumor do not have any of the signs and symptoms described below. (cancer.net)
If a germ cell tumor is diagnosed, relieving symptoms remains an important part of your child's medical care and treatment. (cancer.net)
Signs and symptoms of extragonadal germ cell tumors include breathing problems and chest pain. (vicc.org)
Malignant extragonadal germ cell tumors may cause signs and symptoms as they grow into nearby areas. (vicc.org)
Mediastinal tumors form in the part of the chest between the breastbone and spinal column and can grow without symptoms until they become quite large. (curesearch.org)

The granular cell tumor (GCT) is an uncommon benign neoplasm of soft tissue. (bvsalud.org)
Vered M, Carpenter WM, Buchner A. Granular cell tumor of the oral cavity: updated immunohistochemical profile. (medscape.com)
Granular cell tumor: a review and update. (medscape.com)
Caltabiano R, Cappellani A, Di Vita M, Lanzafame S. The unique simultaneous occurrence of a squamous cell carcinoma and a granular cell tumor of the tongue at the same site: a histological and immunohistochemical study. (medscape.com)
Eagle syndrome produced by a granular cell tumor. (medscape.com)
Granular cell tumor of the tongue in a 6-year-old girl--a case report. (medscape.com)
Multiple granular cell tumor: a case report and review of the literature. (medscape.com)
Dive A, Dhobley A, Fande PZ, Dixit S. Granular cell tumor of the tongue: Report of a case. (medscape.com)
Clinical photograph of a granular cell tumor on the tongue of a 38-year-old man. (medscape.com)

The two main types of germ cell tumors of the brain are germinomas and non-germinomatous tumors. (dana-farber.org)

Unlike germ cell tumors of the testicles, this tumor does not seem to be linked to undescended testes . (medlineplus.gov)

They said that by manipulating various proteins in the stress response pathway within T cells, it is possible to overcome the T cell's intrinsic stress response and enable the immune system to fight against further tumor growth. (medicalnewstoday.com)
An Institut Pasteur team has developed a microfluidic system to observe individual immune cells and model their interactions with tumors. (pasteur.fr)
The scientists successfully monitored the behavior of individual immune cells and were thus able to describe their interactions with tumor models. (pasteur.fr)
This allowed them to analyze interactions between the two cell populations and perform unique, accurate measurements of cell positions and the spatiotemporal process of immune response. (pasteur.fr)
This microfluidic system developed with the support of the Institut Pasteur Biomaterials and Microfluidics Platform could one day be used to perform personalized diagnostics by directly incorporating patients' cells to help predict their immune response. (pasteur.fr)
Miyake, K. & Karasuyama, H. The role of trogocytosis in the modulation of immune cell functions. (nature.com)
Engineered human immune cells can vanquish a deadly pediatric brain tumor in a mouse model, a study from the Stanford University School of Medicine has demonstrated. (stanford.edu)
Cell surface antigens are large molecules sticking out from a cell that help the immune system determine whether the cell is harmless or harmful. (stanford.edu)
WASHINGTON -Tumors have come up with ingenious strategies that enable them to evade detection and destruction by the immune system. (childrensnational.org)
They engineered T-cells, essential players in the body's own immune system, to strip tumors of their self-preservation skill and were able to hold Hodgkin lymphoma at bay in patients with relapsed disease for more than four years. (childrensnational.org)
This most recent study points to the potential of specialized T-cells to fight even more types of immune-evading tumors. (childrensnational.org)
The study team writes that their findings underscore the potential utility of expressing DNRII when battling other tumors that have learned to evade the immune system. (childrensnational.org)
The polymer interacts with a receptor that senses danger to activate cells that trigger an inflammatory immune response. (scienceblog.com)
Tumor-associated macrophages (TAMs) are the most abundant immune cells in tumors. (managedhealthcareexecutive.com)
We have discovered that the molecular composition, more than the extent, of stroma and tumor immune/inflammatory response is of prognostic importance. (lu.se)

Glioblastomas are the most aggressive of all brain tumors. (dkfz.de)
Patients with few of these aggressive cells lying dormant in their surrounding tissue may be less likely to see a tumor reoccur 5, 10, or 20 years later. (news-medical.net)

Many types of bone tumors and other conditions (including normal bone) contain giant cells. (orthoinfo.org)
While most bone tumors occur in the flared area near the ends of the body's long bones (metaphysis), giant cell tumors occur almost exclusively in the end portion of the long bones (epiphysis), directly next to the joints. (orthoinfo.org)
Overview of Bone Tumors Bone tumors are growths of abnormal cells in bones. (msdmanuals.com)

This recent review article summarizes the challenges with developing CAR T-cell therapy for solid tumors and strategies to overcome the hurdles, and lists some of the ongoing clinical trials in which CAR T cells that target tumor antigens, including GD2, CEA, and EGFR, are being currently tested against a variety of solid tumors. (aacr.org)
Our phase 1 CAR T-cell clinical trials against CNS tumors are called BrainChild. (seattlechildrens.org)
What is the goal of the CAR T-cell CNS clinical trials? (seattlechildrens.org)
Who can join the CAR T-cell CNS clinical trials? (seattlechildrens.org)
The PLAT trials are phase 1 and 2 clinical trials testing CAR T-cell therapy in children, teens and young adults with relapsed or refractory acute leukemia or lymphoma. (seattlechildrens.org)

The diagnosis of ectopic pituitary hormone secretion requires abnormally high circulating hormone levels, absence of a pituitary tumor, and localization of the hormone in question to the extrapituitary malignant neoplasm. (nih.gov)
RT-PCR detected prolactin mRNA in the tumor cell extract, confirming the diagnosis of ectopic prolactin synthesis and secretion. (nih.gov)
As a result, cells from the tumor must be biopsied (excised) and studied under a microscope for an accurate diagnosis. (knowcancer.com)
We initially use surgery to biopsy the tumor and form a complete diagnosis. (dana-farber.org)

Like the contents of this gumball machine, tumors are highly heterogeneous and a few specialized cells (green) drive the growth of the entire tumor. (cancer.gov)

People with GCTs need regular follow-up care to monitor for any recurrence or transformation of the tumor. (medicinenet.com)
This brain tumor type is highly proliferative and shows an infiltrative growth pattern, accounting for the high recurrence rates in patients. (hindawi.com)
This new device could be the first step to better assess how likely tumor recurrence is. (news-medical.net)

Germ cell tumors can be either benign or malignant. (texaschildrens.org)

Nanoparticle incorporation transforms them from an immunosuppressive to an immunostimulatory cell type at tumor locations, provoking anti-tumor responses and also directly killing tumor cells. (scienceblog.com)

It was concluded that circulating epithelial cells may be present in patients with benign inflammatory colon which were detectable by CTC assays. (medscape.com)
Moreover, it exclusively detects live CTCs, and its detection efficacy is not impacted by the variation of epithelial cell adhesion molecule expression. (uh.edu)
First, when tumor cells get into the blood, they intend to undergo a biological change called epithelial-mesenchymal transition (EMT). (uh.edu)
Synovial sarcomas encompass both biphasic (epithelial and spindle cell components) and monophasic (purely spindle cell) variants. (medscape.com)
Role of mesothelin in carbon nanotube -induced carcinogenic transformation of human bronchial epithelial cells. (cdc.gov)
In this study, the role of MSLN in the carcinogenic transformation of human bronchial epithelial cells chronically exposed to single-walled CNT (BSW) was investigated. (cdc.gov)
Together, our results indicate a novel role of MSLN in the malignant transformation of bronchial epithelial cells following CNT exposure, suggesting its utility as a potential biomarker and drug target for CNT-induced malignancies. (cdc.gov)

These malignant tumors are also called dysgerminomas when they're in the ovary, or seminomas when they're in the testes. (kidshealth.org)
These findings suggest that these tumors arose from separate endometriosis foci and collided within the same ovary. (hindawi.com)

Since these tumors are typically benign and their growth is slow, outlook is generally very positive. (knowcancer.com)

What Are Germ Cells? (kidshealth.org)
Germ cells are the reproductive cells in an unborn baby. (kidshealth.org)
Before they settle into the reproductive organs, germ cells develop along the baby's "midline. (kidshealth.org)
Because the germ cells travel along the midline to reach the reproductive organs as a fetus grows, they can sometimes settle in other places. (kidshealth.org)
Childhood Central Nervous System (CNS) germ cell tumors form in germ cells, which are cells that develop into sperm or ova (eggs). (texaschildrens.org)
A mixed germ cell tumor has two types of germ cells in it. (texaschildrens.org)
Usually, germ cells migrate to the gonads during fetal development. (dana-farber.org)
However, when these germ cells don't move to the right area, they can become trapped in the brain and multiply in areas where they shouldn't. (dana-farber.org)
In humans, germ cells produce specialized cells needed for reproduction: sperm cells in boys and egg cells in girls. (curesearch.org)

To find new, more effective treatment options for those affected, doctors and scientists are testing numerous immunotherapeutic approaches, including so-called "adoptive" T-cell therapies: This involves isolationg T cells from the patient, modifying them in the culture dish and transferring them back to the patient. (dkfz.de)
Production of transforming growth factor-β in the immediate vicinity of tumors normally thwarts tumor-directed therapies by having devastating effects on T-cell function in vivo. (childrensnational.org)
The existence of such a cell population would have an important impact on the design of novel therapies against this devastating disease. (wjgnet.com)
It does take direct aim at tumor cells, so it could be an amenable adjunct to other current therapies. (scienceblog.com)
Various novel therapies are aimed at disrupting this angiogenesis and so reducing tumour growth. (rkm.com.au)
Data presented here at the conference have demonstrated that it is possible to develop CAR T-cell therapies for solid tumors that are not only safe but also yield clinical benefit for patients. (aacr.org)
Trying to understand as much as we can about genetic versus non-genetic determinants of tumor organization is key to our understanding of tumor propagation and to the design of new therapies. (technologynetworks.com)

These tumors may begin to grow anywhere in the body but usually begin in organs such as the pineal gland in the brain, in the mediastinum (area between the lungs ), or in the retroperitoneum (the back wall of the abdomen ). (vicc.org)

However, there has only been one previous functional study investigating MCT4 in glioblastoma (GBM) neurospheres, mainly focusing on tumor growth and survival dependent on the oxygen level [ 14 ]. (hindawi.com)
It is found in large quantities in glioblastoma cells, but is virtually undetectable in healthy brain tissue. (dkfz.de)
After these initial studies had yielded such promising results, Lukas Bunse expects that vaccine-induced T-cell receptors targeting brain tumor antigens could be a promising approach to develop new immunotherapies against glioblastoma. (dkfz.de)

Extragonadal germ cell tumors form from developing sperm or egg cells that travel from the gonads to other parts of the body. (vicc.org)
These are more common than malignant extragonadal germ cell tumors and often are very large. (vicc.org)
Malignant extragonadal germ cell tumors are divided into two types, nonseminoma and seminoma . (vicc.org)
Age and gender can affect the risk of extragonadal germ cell tumors. (vicc.org)
Imaging and blood tests are used to diagnose extragonadal germ cell tumors. (vicc.org)

Treatment for childhood Germ Cell Tumors often includes surgery. (mdanderson.org)
Within the Childhood Brain Tumor Center , our specialists have extensive expertise in treating all types of brain tumors, including germ cell tumors. (dana-farber.org)
Childhood cutaneous Abrikossoff tumor]. (medscape.com)

A few studies have reported tumors coexisting with SMBTs, such as endometrioid adenocarcinoma [ 4 ] and squamous cell carcinoma [ 5 ]. (hindawi.com)
We identified monocarboxylate transporter 1 (MCT1) as the prominent path for lactate uptake by a human cervix squamous carcinoma cell line that preferentially utilized lactate for oxidative metabolism. (jci.org)

Some people may have a genetic predisposition to developing GCTs, meaning they have a higher risk of developing these tumors due to inherited genetic factors. (medicinenet.com)
Doctors might order genetic tests if a tumor could be related to a genetic condition. (kidshealth.org)
This meant that while you could trap a lot of CTCs you could only get a bit of genetic information out of them, or you could do a complete sequencing but this could be performed on only a few viable cells. (medgadget.com)
They then performed genetic sequencing on these cells and discovered that patients can shed CTCs that are quite different from each other and that up to 50% of the CTCs displayed stem cell-like properties, a particularly interesting finding. (medgadget.com)
Usinga method to detect mismatches in genetic material, they comparedstrands of DNA from tumor cells and surrounding normal tissue,and discovered mutations in the tumor samples. (cancernetwork.com)
Their analysis led the team to another critical finding: weakly adherent cells have a unique genetic signature that identifies them and enables them to migrate and invade faster. (news-medical.net)
The Brain Tumor Stem Cell Research Lab studies genetic controls and mediators of tumor growth, invasion, and migration to understand how tumors move into the healthy brain. (mayo.edu)
Importantly, these three developmental signatures were found in distinct genetic clones - cells with identical patterns of genetic mutations - of tumor cells. (technologynetworks.com)

That's the beautiful part of story-people usually inject these nanoparticles to target tumor cells. (scienceblog.com)

Germ cell tumors that develop in the brain or spinal cord are also called CNS (central nervous system) germ cell tumors. (dana-farber.org)
Is CAR T-cell therapy safe to give to children and young adults with relapsed or refractory CNS tumors (tumors of the brain or spinal cord)? (seattlechildrens.org)

Anatomy21

Organisms11

Diseases79

Chemicals and Drugs50

Analytical, Diagnostic and Therapeutic Techniques and Equipment51

Phenomena and Processes49

Disciplines and Occupations1

Information Science4

Health Care6

Cancer131

Microenvironment4

Cancerous8

Ovarian15

Teratomas5

Circulating Tumor Cells7

Metastatic3

Ovaries7

Cancers12

Human tumors2

Proliferation9

Giant Cell Tumor15

Controlling tumor growth1

Solid tumors that express1

Metastasis4

Progression1

Surgery to remove the tumor1

Immunotherapy5

Diffuse intrinsic pontine glioma2

Yolk1

Malignant germ2

Markers6

Researchers20

Heterogeneous tumor1

Mice4

Protein13

Size of the tumor2

Noncancerous4

Antigen8

Biology5

Tissues6

Primary tumors1

Chemotherapy3

Symptoms7

Granular cell9

Germinomas1

Undescended testes1

Immune15

Aggressive2

Bone tumors3

Clinical trials5

Diagnosis4

Highly heterogeneous1

Recurrence3

Benign or malignant1

Anti-tumor1

Epithelial7

Ovary2

Typically benign1

Germ cells9

Therapies7

Organs1

Glioblastoma3

Extragonadal5

Childhood3

Squamous2

Genetic8

Target tumor1

Brain or spinal cord2