• molecule
  • CD40 - This molecule, found on a variety of immune system cells including antigen presenting cells has CD40L, otherwise known as CD154 and transiently expressed on the surface of activated CD4+ T cells, as its ligand. (wikipedia.org)
  • CD137 - When this molecule, also called 4-1BB, is bound by CD137 ligand, the result is T-cell proliferation. (wikipedia.org)
  • TL1A
  • In contrast, TNF-like protein 1A (TL1A), the ligand for DR3, exacerbated disease in a dose- and DR3-dependent fashion.Treatment with antagonistic anti-TL1A mAb protected animals in a systemic model of RA disease collagen-induced arthritis.We therefore conclude that the DR3-TL1A pathway regulates joint destruction in two murine models of arthritis and represents a potential novel target for therapeutic intervention in inflammatory joint disease. (nih.gov)
  • In contrast, TNF-like protein 1A (TL1A), the ligand for DR3, exacerbated disease in a dose- and DR3-dependent fashion. (nih.gov)
  • proteins
  • Abgent has over fifteen years of experience producing recombinant proteins in E. coli and mammalian cells (CHO and HEK293, etc), and we have added a powerful yeast expression platform to our menu of services. (abgent.com)
  • The TNFR-receptor associated factor adaptor proteins TRAF1, TRAF2, TRAF6 and possibly TRAF5 interact with this receptor serve as mediators of the signal transduction. (wikipedia.org)
  • Bone
  • The most common types of primary bone tumour are osteosarcoma and Ewing's sarcoma, both of which are most frequently diagnosed in children and young adults. (cancerindex.org)
  • The largest bone tumor center in China. (cancerindex.org)
  • Denosumab (trade names Prolia and Xgeva) is a human monoclonal antibody for the treatment of osteoporosis, treatment-induced bone loss, metastases to bone, and giant cell tumor of bone. (wikipedia.org)
  • In June 2010, denosumab was approved by the U.S. Food and Drug Administration (FDA) for use in postmenopausal women with risk of osteoporosis under the trade name Prolia, and in November 2010, as Xgeva, for the prevention of skeleton-related events in patients with bone metastases from solid tumors. (wikipedia.org)
  • On 13 June 2013, the US FDA approved denosumab for treatment of adults and skeletally mature adolescents with giant cell tumor of bone that is unresectable or where resection would result in significant morbidity. (wikipedia.org)
  • OX40
  • Numbers of molecules enhance or dampen IL-9 production and contribute to TH9 development such as: Activin A that can fully substitute the role of TGF-β in TH9 cells, then Jagged2, programmed cell death ligand (PD-L2), cyclooxy- genase (COX)-2, 1,25-dihydroxyvitamin D3, calcitonin gene-related peptide (CGRP), tumor necrosis factor receptor superfamily member 4 (TNFRSF4 or OX40), and thymic stromal lymphopoietin (TSLP). (wikipedia.org)
  • CD40
  • Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary. (wikipedia.org)
  • family
  • Dacetuzumab alone upregulated the proapoptotic p53 family member TAp63α, a suppressor of tumorigenesis. (aacrjournals.org)
  • Like other members of the TNFR family, it has four extracellular cysteine-rich pseudo-repeat domains (CRDs). (wikipedia.org)
  • RANK contains four CRDs spanning a length of 100 Angstroms which makes it the longest member of the TNFR family to date. (wikipedia.org)
  • RANKL's extracellular domains are similar to other TNF family members in regards to the structural homology and are able to cleave from the cell surface. (wikipedia.org)
  • Like many other TGFβ family members, SMAD7 is involved in cell signalling. (wikipedia.org)
  • Membrane
  • The DR6 is an alpha-helical integral membrane receptor protein that shows evidence that it has something to do with the inhibition of blood vessels forming on tumors which would allow them to grow larger. (wikipedia.org)
  • Immunity
  • Mounting evidence from clinical observations in humans and experimental studies in rodents suggests that paracrine signaling by solTNF is associated with chronic inflammation ( 6 , 7 ), whereas juxtacrine signaling by tmTNF plays an essential role in resolving inflammation ( 8 , 9 , 10 ) and maintaining immunity to pathogens including Listeria monocytogenes ( 11 , 12 ) and Mycobacterium tuberculosis ( 13 , 14 , 15 , 16 ). (jimmunol.org)