• TL1A
  • In contrast, TNF-like protein 1A (TL1A), the ligand for DR3, exacerbated disease in a dose- and DR3-dependent fashion.Treatment with antagonistic anti-TL1A mAb protected animals in a systemic model of RA disease collagen-induced arthritis.We therefore conclude that the DR3-TL1A pathway regulates joint destruction in two murine models of arthritis and represents a potential novel target for therapeutic intervention in inflammatory joint disease. (nih.gov)
  • In contrast, TNF-like protein 1A (TL1A), the ligand for DR3, exacerbated disease in a dose- and DR3-dependent fashion. (nih.gov)
  • angiogenesis
  • Defibrotide, an endothelial protective drug based on a polydisperse mixture of single-stranded deoxyribonuleotides, has turned out to inhibit tumor angiogenesis in in vitro and in vivo models. (ucd.ie)
  • RANKL
  • Title: IL-15 and RANKL Play a Synergistically Important Role in Osteoclastogenesis. (nih.gov)
  • RANK is activated by RANKL (the RANK-Ligand), which exists as cell surface molecules on osteoblasts. (wikipedia.org)
  • RANK is the receptor for RANK-Ligand (RANKL) and part of the RANK/RANKL/OPG signaling pathway that regulates osteoclast differentiation and activation. (wikipedia.org)
  • RANKL (Receptor Activator for Nuclear factor κ B Ligand) is found on the surface of stromal cells, osteoblasts, and T cells. (wikipedia.org)
  • Unlike other members of the TNFSF, each surface interaction in RANK-RANKL is continuous. (wikipedia.org)
  • This system is balanced by the relative expression of OPG to RANKL, which are highly regulated by many factors including hormones, immune signals, and growth factors. (wikipedia.org)
  • The balance between RANKL and OPG is a target for therapy in many diseases including estrogen deficiency-associated osteoporosis, rheumatoid arthritis, Paget's disease, periodontal disease, and bone tumors and malignancies. (wikipedia.org)
  • Once the tumor is seeded in the bone, the tumor cells stimulate bone resorption by secreting factors such as RANKL or prompting the surrounding stroma to express growth factors. (wikipedia.org)
  • RANKL is known as a type II membrane protein and is a member of the tumor necrosis factor (TNF) superfamily. (wikipedia.org)
  • RANKL is an apoptosis regulator gene, a binding partner of osteoprotegerin (OPG), a ligand for the receptor RANK and controls cell proliferation by modifying protein levels of Id4, Id2 and cyclin D1. (wikipedia.org)
  • The level of RANKL expression does not linearly correlate to the effect of this ligand. (wikipedia.org)
  • Osteoclastic activity is triggered via the osteoblasts' surface-bound RANKL activating the osteoclasts' surface-bound receptor activator of nuclear factor kappa-B (RANK). (wikipedia.org)
  • Signal Transduction
  • One major goal of this research project is to unravel the signal transduction mechanisms of Defibrotide and its yet to be identified receptor(s) in order to optimize anti-tumor angiogenic strategies. (ucd.ie)
  • The cytoplasmic region of this receptor was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response. (wikipedia.org)
  • proteins
  • Abgent has over fifteen years of experience producing recombinant proteins in E. coli and mammalian cells (CHO and HEK293, etc), and we have added a powerful yeast expression platform to our menu of services. (abgent.com)
  • It belongs to the SMAD family of proteins, which belong to the TGFβ superfamily of ligands. (wikipedia.org)
  • Bone
  • The most common types of primary bone tumour are osteosarcoma and Ewing's sarcoma, both of which are most frequently diagnosed in children and young adults. (cancerindex.org)
  • The largest bone tumor center in China. (cancerindex.org)
  • Denosumab (trade names Prolia and Xgeva) is a human monoclonal antibody for the treatment of osteoporosis, treatment-induced bone loss, metastases to bone, and giant cell tumor of bone. (wikipedia.org)
  • In June 2010, denosumab was approved by the U.S. Food and Drug Administration (FDA) for use in postmenopausal women with risk of osteoporosis under the trade name Prolia, and in November 2010, as Xgeva, for the prevention of skeleton-related events in patients with bone metastases from solid tumors. (wikipedia.org)
  • On 13 June 2013, the US FDA approved denosumab for treatment of adults and skeletally mature adolescents with giant cell tumor of bone that is unresectable or where resection would result in significant morbidity. (wikipedia.org)
  • OX40
  • Numbers of molecules enhance or dampen IL-9 production and contribute to TH9 development such as: Activin A that can fully substitute the role of TGF-β in TH9 cells, then Jagged2, programmed cell death ligand (PD-L2), cyclooxy- genase (COX)-2, 1,25-dihydroxyvitamin D3, calcitonin gene-related peptide (CGRP), tumor necrosis factor receptor superfamily member 4 (TNFRSF4 or OX40), and thymic stromal lymphopoietin (TSLP). (wikipedia.org)
  • CD40
  • Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary. (wikipedia.org)
  • Immunity
  • Mounting evidence from clinical observations in humans and experimental studies in rodents suggests that paracrine signaling by solTNF is associated with chronic inflammation ( 6 , 7 ), whereas juxtacrine signaling by tmTNF plays an essential role in resolving inflammation ( 8 , 9 , 10 ) and maintaining immunity to pathogens including Listeria monocytogenes ( 11 , 12 ) and Mycobacterium tuberculosis ( 13 , 14 , 15 , 16 ). (jimmunol.org)
  • cells
  • His major research focus is on endothelial and mesenchymal stem cells in transplant medicine and oncology, i.e. the monitoring and preventing endothelial-specific adverse immunological reactions in transplant settings and the development of new tumour-specific anti-angiogenic strategies in cancer. (ucd.ie)
  • This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. (wikipedia.org)
  • This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. (wikipedia.org)
  • STAT6 repress the expression of transcription factors T-bet and Foxp3 in TH9 cells, that normally block IL-9 production. (wikipedia.org)
  • GATA-3 in TH9 cells development represses transcriptional factor FOXP3, which would other wise let to other T helper cell subpopulation. (wikipedia.org)
  • STAT5, downstream factor of IL-2, induce TH9 cells IL-9. (wikipedia.org)
  • Siva protein is a zinc-containing intracellular ligand of the CD4 receptor that promotes HIV-1 envelope-induced apoptosis in T-lymphoid cells. (wikipedia.org)
  • family
  • RANKL's extracellular domains are similar to other TNF family members in regards to the structural homology and are able to cleave from the cell surface. (wikipedia.org)
  • Like many other TGFβ family members, SMAD7 is involved in cell signalling. (wikipedia.org)