PancuroniumBlockadeAnesthesiaImpair neuromuscular transmissionBlockersJunctionsParalysisAtracuriumRocuroniumBlocking AgentsJunctionClinicalAnesthesiologyCompetitiveTherapeuticallyPatientsMivacuriumDiaphragmAlkaloidStimulationTransmission1981HistamineReversalAdverseDrugsContrastMuscleEffectGroupPlantActions
Pancuronium2
- Competitive neuromuscular blocking agents, such as d-tubocurarine and pancuronium, have an exaggerated and prolonged effect in patients with LEMS. (medscape.com)
- For instance, non-depolarising neuromuscular blockers like d-tubocurarine, pancuronium, vecuronium, atracurium and depolarising neuromuscular blocker like suxamethonium all act on nicotinic acetylcholine receptors (nAChR) which are of ionotropic receptors. (egpat.com)
Blockade9
- 5. Which of the following diseases can augment the neuromuscular blockade produced by nondepolarizing musclerelaxants? (remixeducation.in)
- Neuromuscular blockade and respiratory paralysis have also been reported following administration. (drugs.com)
- In this in vivo experiment, we investigated the differences in the recovery of rocuronium-induced neuromuscular blockade using sugammadex pre-exposed with two different concentrations of hydrocortisone. (anesth-pain-med.org)
- When sugammadex was pre-exposed to a high dose of hydrocortisone only, recovery from neuromuscular blockade was delayed. (anesth-pain-med.org)
- Delayed recovery from neuromuscular blockade is not always plausible when sugammadex is pre-exposed to steroidal drugs. (anesth-pain-med.org)
- Before the introduction of sugammadex, the main method of antagonizing neuromuscular blockade was by administering anticholinesterase, to increase acetylcholine levels in neuromuscular junctions, thereby competing with rocuronium in binding to postsynaptic nicotinic acetylcholine receptors [ 5 , 6 ]. (anesth-pain-med.org)
- However, this indirect manner of antagonizing neuromuscular blockade has a ceiling effect in reversing rocuronium-induced neuromuscular block, giving rise to limitations and considerations, such as the depth of neuromuscular block at the time of reversal [ 7 ]. (anesth-pain-med.org)
- In contrast, the mechanism of sugammadex-induced recovery from neuromuscular blockade is through the encapsulation of host molecules and their inactivation [ 4 ]. (anesth-pain-med.org)
- 6. Tacrine and HP029 behave predominantly as anticholinesterase agents, while HP128 has weaker anticholinesterase actions that are masked by cholinoceptor blockade. (inra.fr)
Anesthesia5
- Regardless, all in all some 30,000 patients had been given tubocurarine by 1941, although it was Griffith and Johnson's 1942 publication that provided the impetus to the standard use of neuromuscular blocking agents in clinical anesthetic practice - a revolution that rapidly metamorphosized into the standard practice of "balanced" anesthesia: the triad of barbiturate hypnosis, light inhalational anesthesia and muscle relaxation. (wikipedia.org)
- Present clinical anesthetic practice still employs the central principle of balanced anesthesia though with some differences to accommodate subsequent technological advances and introductions of new and better gaseous anesthetic, hypnotic and neuromuscular blocking agents, and tracheal intubation, as well as monitoring techniques that were nonexistent in the day of Gray and Halton: pulse oximetry, capnography, peripheral nerve stimulation, noninvasive blood pressure monitoring, etc. (wikipedia.org)
- Initial signs of possible LEMS include prolonged weakness or apnea following administration of neuromuscular blocking agents during anesthesia. (medscape.com)
- Before induction of anesthesia, a train-of-four (TOF) electromyography was installed in order to monitor neuromuscular function during operation. (asahq.org)
- While usually administered with inhalational agents, general anesthesia can be achieved with intravenous agents, such as propofol . (wikidoc.org)
Impair neuromuscular transmission1
- Unless absolutely necessary, avoid drugs that are known to impair neuromuscular transmission. (medscape.com)
Blockers1
- As with other nondepolarizing neuromuscular blockers, the time to onset of paralysis decreases and the duration of maximum effect increases with increasing doses of metocurine iodide. (chembase.cn)
Junctions1
- Long-term "therapeutic" doses of physostigmine chemically altered her neuromuscular junctions to the point where she had to be slowly weaned from the drug. (medscape.com)
Paralysis2
- Botulinum toxin causes neuromuscular paralysis by blocking acetylcholine release. (britannica.com)
- This provides a useful way to terminate paralysis produced by tubocurarine or similar drugs at the end of surgical procedures. (britannica.com)
Atracurium1
- Histamine-releasing potencies of atracurium, dimethyl tubocurarine and tubocurarine. (cornell.edu)
Rocuronium2
- Sugammadex is a prime antagonist of aminosteroidal neuromuscular blocking agents (NMBAs), especially rocuronium [ 1 - 3 ]. (anesth-pain-med.org)
- Ishigaki S., Ogura T., Kanaya A. Influence of preoperative oral rehydration on arterial plasma rocuronium concentration and neuromuscular blocking effects: A randomized controlled trial. (intensive-care.ru)
Blocking Agents10
- because of higher risk of toxicity and proarrhythmic effects, antiarrhythmic agents generally reserved for patients who do not respond to or cannot be treated with AV nodal blocking agents (β-adrenergic blocking agents, verapamil, diltiazem). (drugs.com)
- however, more limited role and generally considered only when IV β-adrenergic blocking agents are ineffective. (drugs.com)
- Neuromuscular blocking drugs act on acetylcholine receptors and fall into two distinct groups: nondepolarizing (competitive) and depolarizing blocking agents. (britannica.com)
- If intubation proves necessary, the use of neuromuscular blocking agents may further exacerbate the weakness and have prolonged effects (see Avoidance of weakness-exacerbating drugs). (medscape.com)
- RESISTANCE to nondepolarizing neuromuscular blocking agents (NMBAs) occurs in many clinical diseases and drug interactions. (asahq.org)
- The use of neuromuscular blocking agents should be avoided in patients receiving QUALAQUIN. (medlibrary.org)
- 1982. Histamine release by neuromuscular blocking agents in man. . (cornell.edu)
- The pharmacology of new short-acting nondepolarizing ester neuromuscular blocking agents: clinical implications. (cornell.edu)
- Sugammadex is a specific antagonist of aminosteroidal neuromuscular blocking agents with 1:1 binding to guest molecules. (anesth-pain-med.org)
- Members of this group frequently act as antihypertensive agents and selective ganglionic blocking agents. (lookformedical.com)
Junction5
- Thus, tubocurarine is effective only if given parenterally, as demonstrated by Bernard, who also showed that the site of its action was at the neuromuscular junction. (wikipedia.org)
- The motor nerve fibres reach the muscle fibres at sites called motor end plates, which are located roughly in the middle of each muscle fibre and store vesicles of the neurotransmitter acetylcholine (this meeting of nerve and muscle fibres is known as the neuromuscular junction ). (britannica.com)
- Because this mechanism is relatively insensitive to drug action, the most important group of drugs that affect the neuromuscular junction act on (1) acetylcholine release, (2) acetylcholine receptors, or (3) the enzyme acetylcholinesterase (which normally inactivates acetylcholine to terminate muscle fibre contraction). (britannica.com)
- Neuromuscular junction (NMJ) is the functional contact (synapse) between an axon of motor neuron and muscle fiber. (intechopen.com)
- Antibodies are present at the neuromuscular junction (NMJ), the site of pathology. (kieran101.com)
Clinical1
- Griffith and Johnson are credited with pioneering the formal clinical introduction of tubocurarine as an adjunct to anesthetic practice on 23 January 1942, at the Montreal Homeopathic Hospital. (wikipedia.org)
Anesthesiology1
- InterviewAnswers by Any resident in Anesthesiology … Ans:b, 64.Which of the following anesthetic agent sensitizes the heart to adrenaline c) Propofur a)1% a)Isoflurane Anesthesiologist : An anesthesiologist is a doctor that completed medical school, a four-year residency program, and often a one-year subspecialty fellowship. (usiad.net)
Competitive3
- Competitive neuromuscular blocking drugs act as antagonists at acetylcholine receptors, reducing the effectiveness of acetylcholine in generating an end-plate potential . (britannica.com)
- in the presence of a competitive neuromuscular blocking agent, transmission can be restored. (britannica.com)
- Metocurine iodide is a benzylisoquinolinium competitive nondepolarizing neuromuscular blocking agent. (chembase.cn)
Therapeutically1
- Several organophosphate agents are being tried therapeutically. (medscape.com)
Patients1
- 3. Which neuromuscular blocking agent is contraindicated in patients with glaucoma? (remixeducation.in)
Mivacurium1
- Short-acting neuromuscular blocking agent (NMBA), mivacurium (11 mg), was administered to facilitate tracheal intubation. (asahq.org)
Diaphragm1
- 3. In mouse diaphragm preparations that were partially paralysed by tubocurarine or low calcium solutions, tacrine, HP029, and 3,4-diaminopyridine reversed the twitch block. (inra.fr)
Alkaloid2
- Tubocurarine (also known as d-tubocurarine or DTC) is a toxic benzylisoquinoline alkaloid historically known for its use as an arrow poison. (wikipedia.org)
- Tubocurarine is a naturally occurring mono-quaternary alkaloid obtained from the bark of the Menispermaceous South American plant Chondrodendron tomentosum, a climbing vine known to the European world since the Spanish conquest of South America. (wikipedia.org)
Stimulation1
- A continuous record from peri-operative evoked electromyographic monitoring (Train-of-four stimulation, a Datex neuromuscular transmission monitor). (asahq.org)
Transmission3
- Drugs that compromise neuromuscular transmission frequently exacerbate weakness in LEMS. (medscape.com)
- Depolarization, either by a recent excitation of the comb plate or by agents like ouabain causes increased excitability and a more rapid transmission. (biologists.com)
- They function as cholinesterase inhibitors, thereby affecting neuromuscular transmission. (medscape.com)
19811
- 1981. Role of histamine in the hypotensive action of d-tubocurarine in humans. . (cornell.edu)
Histamine1
- Apart from histamine, agents known to function as local hormones are prostanoids. (britannica.com)
Reversal1
- In sugammadex-induced antagonism, the depth of neuromuscular block at the time of reversal is irrelevant, which means that increasing the dose of sugammadex enables rapid recovery from a deep or intense neuromuscular block [ 1 , 3 ]. (anesth-pain-med.org)
Adverse2
- Curare had been used as a source of arrow poison by South American natives to hunt animals, and they were able to eat the animals' contaminated flesh subsequently without any adverse effects because tubocurarine cannot easily cross mucous membranes. (wikipedia.org)
- Because of procainamide's arrhythmogenic potential, lack of evidence for improved survival for class I antiarrhythmic agents, and risk of serious, potentially fatal adverse hematologic effects (see Boxed Warning), particularly leukopenia or agranulocytosis, use for less severe arrhythmias not recommended. (drugs.com)
Drugs1
- [ 2 ] This explains the action of these drugs and may result in development of more effective agents. (medscape.com)
Contrast1
- Exacerbation of LEMS after administration of any of several other agents, including magnesium and IV iodinated radiographic contrast agents, has been reported in isolated cases. (medscape.com)
Muscle1
- So, according to numerous studies, not only ACh (which by the way does not always lead to a contraction of the muscle fiber) is released in the vertebrate neuromuscular synapse, but also a number of other synaptically active molecules. (intechopen.com)
Effect1
- Repeated administration of maintenance doses of metocurine iodide has no cumulative effect on the duration of neuromuscular block if recovery is allowed to begin prior to repeat dosing. (chembase.cn)
Group1
- The additional methyl group is transferred to form tubocurarine, with its single quaternary N,N-dimethylamino group. (wikipedia.org)
Plant1
- Tubocurarine is so-called because some of the plant extracts designated curare were stored, and subsequently shipped to Europe, in bamboo tubes. (wikipedia.org)
Actions1
- Agents that inhibit the actions of the parasympathetic nervous system. (lookformedical.com)