• cytotrophoblasts
  • CONCLUSIONS: The data indicate that 15-hydroxyeicosatetraenoic acid is produced in trophoblasts and its release by cytotrophoblasts is higher in preeclamptic pregnancies compared with normal controls. (biomedsearch.com)
  • 1998
  • Stem Cell Research A notable segment of Rossant's research has been her work leading to the 1998 discovery of the trophoblast stem cell. (wikipedia.org)
  • cell
  • Clark DA, Slapsys R, Chaput A, et al: Immu no regulatory molecules of trophoblast and decidual suppressor cell origin at the maternofetal interface. (springer.com)
  • Some placental cell lines derived from trophoblasts also express C19MC miRNA, including the choriocarcinoma lines JEG3, JAr, and BeWo, but not HTR8/SVneo. (wikipedia.org)
  • Her work led to the ability to isolate permanent trophoblast stem cell lineages using fibroblast growth factor 4 (FGF4) in contact with mouse blastocysts or early postimplantation trophoblasts. (wikipedia.org)
  • secretion
  • We report that anti-beta(2)GPI antibodies trigger an inflammatory response in trophoblast, characterized by increased secretion of interleukin (IL)-8, MCP-1, GRO-alpha, and IL-1beta, and that this occurs in a TLR-4/MyD88-dependent manner. (nih.gov)
  • Enhanced IL-8, GRO-alpha, and IL-1beta secretion also occurred when trophoblast cells were incubated with antibodies from patients with antiphospholipid syndrome. (nih.gov)
  • Estrogen-enhanced apical and basolateral secretion of apolipoprotein B-100 by polarized trophoblast-derived BeWo cells. (meduniwien.ac.at)
  • Survival
  • This was attenuated upon disabling of the MyD88 pathway, suggesting that anti-beta(2)GPI-induced inflammatory mediators compromise trophoblast survival by acting in an autocrine/paracrine manner. (nih.gov)
  • These findings demonstrate that aPL triggers a placental inflammatory response via the TLR-4/MyD88 pathway, which in turn compromises trophoblast survival. (nih.gov)
  • OBJECTIVE
  • OBJECTIVE: We tested the hypothesis that trophoblast produces 15-hydroxyeicosatetraenoic acid, and its level is elevated in trophoblast from preeclamptic women compared with normal. (biomedsearch.com)
  • The objective of this study was to determine the effects of aPL on trophoblast function and the mechanisms involved. (nih.gov)