• We sought to evaluate the relation between atrial fibrillation (AF) and the extent of myocardial scarring together with left ventricular (LV) and atrial parameters assessed by late gadolinium-enhancement (LGE) cardiovascular magnetic resonance (CMR) in patients with hypertrophic cardiomyopathy (HCM). (1library.net)
  • Over recent decades, it has become increasingly apparent that the heart is intimately sensitive to immune signaling and that myocardial leukocytes exhibit an array of critical functions, both in homeostasis and in the context of cardiac adaptation to injury. (bvsalud.org)
  • This review aims to summarize recent developments in the understanding of pathology, symptomatology, diagnosis, and treatment effects in Fabry disease. (biomedcentral.com)
  • This work offers a new perspective for understanding the cellular mediators of diabetes-induced cardiac pathology, and pathways that may be targeted to address the cardiac complications associated with diabetes. (bvsalud.org)
  • Both exercise-induced molecular mechanisms and physiological cardiac remodeling have been previously studied on a whole heart level. (researchgate.net)
  • However, the regional microstructural tissue effects of these molecular mechanisms in the heart have yet to be spatially linked and further elucidated. (researchgate.net)
  • Taken together, CITED4 expression is necessary for exercise-induced regional remodeling of the heart's microstructural helicity revealing how a key molecular regulator of cardiac remodeling manifests into downstream local tissue-level changes. (researchgate.net)
  • Expression of transcription factor CITED4 is necessary for exercise-induced regional remodeling of the heart's microstructural helicity, revealing how a key molecular regulator of cardiac remodeling mediates local tissue-level changes. (researchgate.net)
  • However, despite extensive efforts to characterize the phenotype of the diabetic heart, the molecular and cellular protagonists that underpin cardiac pathological remodeling in diabetes remain unclear, with a notable paucity of data regarding the impact of diabetes on non-myocytes within the heart. (bvsalud.org)
  • In cultured primary fibroblasts and cancer cells, the chemotherapeutic drug doxorubicin causes mtDNA damage and release, which leads to cGAS STING dependent ISG activation. (regenerativemedicine.net)
  • Basic fibroblast growth factor (Fgf2) is required for the generation of founder cells within the dorsal pseudostratified ventricular epithelium, which will generate the cerebral cortex, but the ganglionic eminences are not affected. (jneurosci.org)
  • It was designed with considerations for (1) time required to extract cardiac cells, (2) cell viability, and (3) protocol scalability. (bvsalud.org)
  • [ 16 ] Hypertrophy or bony overgrowth predominates in patients with HOA secondary to lung cancer, whereas acro-osteolysis predominates in patients with HOA secondary to cyanotic congenital heart disease. (medscape.com)
  • [ 17 ] Hypertrophy or bony overgrowth predominates in patients with lung cancer and HPOA, whereas acroosteolysis predominates in patients with cyanotic congenital heart disease and hypertrophic osteoarthropathy. (medscape.com)
  • Although considerable progress has been made in elucidating the molecular pathogenesis of cardiac hypertrophy, the precise mechanisms guiding the hypertrophic process remain unknown. (pharmaceuticalintelligence.com)
  • We further show that heterozygous and homozygous itga3b/bdf mutant embryos display a cardiomyopathy phenotype, with decreased cardiac contractility and reduced cardiomyocyte number. (bvsalud.org)
  • Together, our results reveal that Itga3b localizes to the myocardium sarcolemma, and it is required for cardiac contractility and cardiomyocyte proliferation. (bvsalud.org)
  • HB-EGF secretion by a given cardiomyocyte in mouse left ventricles led to cellular hypertrophy and reduced expression of connexin43 in the overexpressing cell and in immediately adjacent cells but not in cells farther away. (pharmaceuticalintelligence.com)
  • PURPOSE This solicitation invites research grants focused on the mechanisms responsible for the additive or synergistic effects of alcohol abuse and HIV infection in development of cardiomyopathy. (nih.gov)
  • PMID- 5097525 TI - Animalizing effects of Evans blue in embryos of Arbacia punctulata. (nih.gov)
  • In vivo evaluation of the bystander effect in mouse models demonstrated that for effective therapy, at least 1% of tumor cells need to be delivered with TK-NTR-encoding MCs. (regenerativemedicine.net)
  • The excised specimen was measured as 6.2 × 4.3 × 2.9 cm which would cause significant adverse hemodynamic effects on the heart. (biomedcentral.com)
  • PMID- 5097510 TI - Base lines for measuring adverse effects of air pollution: some evidence for weather effects on mortality. (nih.gov)
  • Effect of cycloheximide on DNA chain elongation. (nih.gov)
  • PMID- 5097518 TI - Effects of -amanitin on mouse and rat liver cell nuclei. (nih.gov)
  • This is Part II of the ongoing research in the Lee Laboratory, concerned with Richard T Lee's dissection of the underlying problems that will lead to a successful resolution of myocardiocyte regeneration unhampered by toxicity, and having a suffuciently sustained effect for an evaluation and introduction to the clinic. (pharmaceuticalintelligence.com)